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https://www.readbyqxmd.com/read/27933587/development-of-a-more-efficient-albumin-based-delivery-system-for-gambogic-acid-with-low-toxicity-for-lung-cancer-therapy
#1
Yan Zhang, Zhijie Yang, Xinyi Tan, Xing Tang, Zaixing Yang
Gambogic acid (GA) has been proven to be a potent chemotherapeutic agent for the treatment of lung cancer in clinical trials. However, GA is limited in its therapeutic value by properties such as poor water solubility and low chemical stability. In clinical trials, cationic arginine (Arg) was added to solubilize GA, and this may also cause other side effects. Here, we have designed and developed a more efficient human serum albumin (HSA)-based delivery system for GA with low toxicity which helps improve its solubility, chemical stability and increases its antitumor efficacy...
December 8, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27932615/anopheles-salivary-biomarker-to-assess-malaria-transmission-risk-along-the-thailand-myanmar-border
#2
Phubeth Ya-Umphan, Dominique Cerqueira, Daniel M Parker, Gilles Cottrell, Anne Poinsignon, Franck Remoue, Cecile Brengues, Theeraphap Chareonviriyaphap, Francois Nosten, Vincent Corbel
BACKGROUND: The modalities of malaria transmission along the Thailand-Myanmar border are poorly understood. Here we address the relevance of using a specific Anopheles salivary biomarker to measure the risk of human exposure to anopheles bites. METHODS: Serologic surveys were conducted from May 2013 to December 2014 in 4 sentinel villages. Dried blood spots (n>9,400) were collected in filter papers among all inhabitants at baseline and then every three months up to 18 months...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27932018/the-determinants-of-essential-newborn-care-for-home-births-in-bangladesh
#3
T Akter, A Dawson, D Sibbritt
OBJECTIVES: To examine the association of sociodemographic, antenatal and delivery care factors with the essential newborn care (ENC) practices of neonates born at home in Bangladesh. STUDY DESIGN: This study analyzed data of a cross-sectional survey-the Bangladesh Demographic and Health Survey, 2011. METHODS: This analysis considered 3190 most recent live-born infants who were delivered at home within three years of the survey. Logistic regression models were used to identify the factors affecting the implementation of six ENC practices, namely using disinfected instruments to cut the umbilical cord, avoidance of application of any substances to the umbilical cord stump, immediate drying and wrapping of newborns, delayed bathing of newborns, and immediate initiation of breastfeeding...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931630/infectious-complications-in-gastrointestinal-endoscopy-and-their-prevention
#4
REVIEW
Julia Kovaleva
Gastrointestinal endoscopes are medical devices that have been associated with outbreaks of health care-associated infections. Because of the severity and limited treatment options of infections caused by multidrug-resistant Enterobacteriaceae and Pseudomonas aeruginosa, considerable attention has been paid to detection and prevention of these post-endoscopic outbreaks. Endoscope reprocessing involves cleaning, high-level disinfection/sterilization followed by rinsing and drying before storage. Failure of the decontamination process implies the risk of settlement of biofilm producing species in endoscope channels...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27930973/phytosomal-curcumin-a-review-of-pharmacokinetic-experimental-and-clinical-studies
#5
REVIEW
Hamed Mirzaei, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, Amirhossein Sahebkar
Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27929366/in-vitro-gastrointestinal-resistant-pectin-hydrogel-particles-for-%C3%AE-glucuronidase-adsorption
#6
Sergey V Popov, Pavel A Markov, Olga A Patova, Fedor V Vityazev, Larisa A Bakutova, Mikhail F Borisenkov, Ekaterina A Martinson, Boris A Ananchenko, Eugene A Durnev, Andrey A Burkov, Sergey G Litvinets, Vladimir A Belyi, Elena A Ipatova
Pectin hydrogel particles (PHPs) were prepared by ionotropic gelation of low methylesterified pectin of Tanacetum vulgare L. with calcium ions. Wet PHPs prepared from TVF exhibited a smaller diameter and the lower weight as well as exhibited the best textural properties in terms of hardness and elasticity compared to the PHPs prepared from commercial low methylesterified pectin (CU701) used for comparison. Upon air drying, PHPs prepared from CU701 became small and dense microspheres whereas the dry PHPs prepared from TVF exhibited a drop-like shape...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27929169/-18-f-fluoride-capture-and-release-azeotropic-drying-free-nucleophilic-aromatic-radiofluorination-assisted-by-a-phosphonium-borane
#7
Cécile Perrio, Sébastien Schmitt, Daniel Pla, François P Gabbaï, Kantapat Chansaenpak, Béatrice Mestre-Voegtle, Emmanuel Gras
[(18)F]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [(18)F]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph2MeP)C6H4(BMes2)](+), then releasing by elution of TBACN in dry acetonitrile. Subsequent radiofluorination was successfully applied to a model reaction and to the radiosynthesis of [(18)F]-setoperone.
December 8, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27928754/production-of-%C3%AE-1-4-glucosidase-from-bacillus-licheniformis-kibge-ib4-by-utilizing-sweet-potato-peel
#8
Muhammad Asif Nawaz, Zainab Bibi, Asad Karim, Haneef Ur Rehman, Muhsin Jamal, Tour Jan, Afsheen Aman, Shah Ali Ul Qader
In the current study, sweet potato peel (Ipomoea batatas) was observed as the most favorable substrate for the maximum synthesis of α-1,4-glucosidase among various agro-industrial residues. Bacillus licheniformis KIBGE-IB4 produced 6533.0 U ml(-1) of α-1,4-glucosidase when growth medium was supplemented with 1% dried and crushed sweet potato peel. It was evident from the results that bacterial isolate secreted 6539.0 U ml(-1) of α-1,4-glucosidase in the presence of 0.4% peptone and meat extract with 0...
December 8, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27928138/essential-oil-composition-antioxidant-antidiabetic-and-antihypertensive-properties-of-two-afromomum-species
#9
Stephen Adeniyi Adefegha, Tosin Abiola Olasehinde, Ganiyu Oboh
This study was designed to assess the antioxidant, antidiabetic and antihypertensive effects of essential oils from A. melegueta and A. danielli seeds. The essential oils were extracted via hydrodistillation, dried with anhydrous Na2SO4 and characterized using gas chromatography-mass spectrometry (GC-MS). Antioxidant properties and inhibition of some pro-oxidant induced lipid peroxidation in rats' pancreas and heart homogenates were also determined. The results revealed that eugenol, eucalyptol, α-terpineol, α-caryophyllene and β-caryophyllene were the most abundant components in A...
December 8, 2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27928060/gasification-an-alternative-solution-for-energy-recovery-and-utilization-of-vegetable-market-waste
#10
Sunil L Narnaware, Nsl Srivastava, Samir Vahora
Vegetables waste is generally utilized through a bioconversion process or disposed of at municipal landfills, dumping sites or dumped on open land, emitting a foul odor and causing health hazards. The presents study deals with an alternative way to utilize solid vegetable waste through a thermochemical route such as briquetting and gasification for its energy recovery and subsequent power generation. Briquettes of 50 mm diameter were produced from four different types of vegetable waste. The bulk density of briquettes produced was increased 10 to 15 times higher than the density of the dried vegetable waste in loose form...
December 6, 2016: Waste Management & Research
https://www.readbyqxmd.com/read/27927911/comparison-of-methodologies-in-determining-bone-marrow-fat-percentage-under-different-environmental-conditions-assessing-a-tool-for-ruminant-welfare-investigations
#11
David Murden, Jaimie Hunnam, Bert De Groef, Grant Rawlin, Christina McCowan
The use of bone marrow fat percentage has been recommended in assessing body condition at the time of death in wild and domestic ruminants, but few studies have looked at the effects of time and exposure on animal bone marrow. We investigated the utility of bone marrow fat extraction as a tool for establishing antemortem body condition in postmortem specimens from sheep and cattle, particularly after exposure to high heat, and compared different techniques of fat extraction for this purpose. Femora were collected from healthy and "skinny" sheep and cattle...
December 6, 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27927637/options-for-basing-dietary-reference-intakes-dris-on-chronic-disease-endpoints-report-from-a-joint-us-canadian-sponsored-working-group
#12
REVIEW
Elizabeth A Yetley, Amanda J MacFarlane, Linda S Greene-Finestone, Cutberto Garza, Jamy D Ard, Stephanie A Atkinson, Dennis M Bier, Alicia L Carriquiry, William R Harlan, Dale Hattis, Janet C King, Daniel Krewski, Deborah L O'Connor, Ross L Prentice, Joseph V Rodricks, George A Wells
Dietary Reference Intakes (DRIs) are used in Canada and the United States in planning and assessing diets of apparently healthy individuals and population groups. The approaches used to establish DRIs on the basis of classical nutrient deficiencies and/or toxicities have worked well. However, it has proved to be more challenging to base DRI values on chronic disease endpoints; deviations from the traditional framework were often required, and in some cases, DRI values were not established for intakes that affected chronic disease outcomes despite evidence that supported a relation...
December 7, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27927067/curcumin-suppresses-inflammatory-cytokines-and-heat-shock-protein-70-release-and-improves-metabolic-parameters-during-experimental-sepsis
#13
Letycia Silvano da Silva, Carlos Henrique Rocha Catalão, Tatiana Tocchini Felippotti, Gabriela Ravanelli de Oliveira-Pelegrin, Sérgio Petenusci, Luis Alexandre Pedro de Freitas, Maria José Alves Rocha
CONTEXT: Curcumin has been reported to have anti-inflammatory, antioxidant and hypoglycaemic properties, besides reducing mortality in sepsis. OBJECTIVE: This study evaluates the biological activities of a curcumin dispersion formulated by spray-drying in experimental sepsis. MATERIALS AND METHODS: Male Wistar rats were subjected to sepsis by caecal ligation and puncture (CLP), controls were sham operated. The animals were treated with curcumin dispersion (100 mg/kg, p...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27926538/effect-of-spirogyra-neglecta-on-the-early-stages-of-1-2-dimethylhydrazine-induced-colon-carcinogenesis-in-rats
#14
Sirinya Taya, Tarika Thumvijit, Teera Chewonarin, Charatda Punvittayagul, Rawiwan Wongpoomchai
This study focused on the chemopreventive effects of Spirogyra neglecta extract (SNE) and dried S. neglecta mixed diet on the early stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats. Male Wistar rats were injected with DMH to initiate aberrant crypt foci (ACF) formation. In the initiation stage, SNE significantly decreased the number of ACF in the colon of DMH-treated rats. Rats that received a low dose of SNE showed enhanced activity of several detoxifying and antioxidant enzymes. In the postinitiation stage, a low dose of SNE significantly decreased the number of ACF in the colon of DMH-treated rats...
December 6, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27925493/the-effect-of-freeze-drying-on-the-nutrient-polyphenol-and-oxidant-levels-of-breast-milk
#15
Mariela Valentina Cortez, Elio Andrés Soria
OBJECTIVES: Human milk banks need to extend the suitability of milk for breastfeeding, and for this technological advances are required. Our aim was to establish the capacity of freeze-drying to conserve milk properties without further oxidative deterioration. METHODS: One hundred sixteen healthy women participated from the city of Cordoba (Argentina). Proteins, glucose, triglycerides, polyphenols, and markers (nitrites, superoxide anion, hydroperoxides, lipoperoxides, and γ-glutamyl transpeptidase) were measured in their fresh milk...
December 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27925210/effects-of-steam-microwave-blanching-and-different-drying-processes-on-drying-characteristics-and-quality-attributes-of-thunbergia-laurifolia-linn-leaves
#16
Traiphop Phahom, Singhanat Phoungchandang, William L Kerr
BACKGROUND: Dried Thunbergia laurifolia leaves are usually prepared using tray drying, resulting in products that have lost substantial amounts of bioactive compounds and antioxidant activity. The maturity of the raw material, blanching techniques and drying methods were investigated in order to select the best condition to produce high qualities of dried T. laurifolia leaves. RESULTS: The 1(st) stage of maturity was selected and steam-microwave blanching (SMB) for 4 min was adequate for blanching leading to the maximum recovery of bioactive compounds...
December 7, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27925030/production-of-crispy-bread-snacks-containing-chicken-meat-and-chicken-meat-powder
#17
Hulya Cakmak, Burak Altinel, Seher Kumcuoglu, Duygu Kisla, Sebnem Tavman
Chicken meat in two different forms (chicken meat and chicken meat powder) were added into white flour and whole wheat blend baguette bread formulations for protein enrichment and finally developing new and healthy snacks. The chicken meat and powder levels were 10% for white flour baguette, and 15% for whole wheat blend. The dried baguette samples were packaged under 100% N2, and physical, chemical, microbiological and sensorial properties were evaluated during 3 months of storage. Protein content of chicken meat powder added samples were found statistically higher than chicken meat added samples...
December 1, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27925011/post-harvest-embryo-development-in-ginseng-seeds-increases-desiccation-sensitivity-and-narrows-the-hydration-window-for-cryopreservation
#18
E Han, E Popova, G Cho, S Park, S Lee, H W Pritchard, H H Kim
BACKGROUND: Despite its self-pollinating characteristics, Korean ginseng germplasm is mainly maintained in clonal gene banks as there is no defined approach to the long-term conservation of its seed, including the most appropriate stage of embryo development for storage. OBJECTIVE: The aim of this study was to reveal the effect of embryo development on desiccation tolerance and cryopreservation success in ginseng seeds. MATERIALS AND METHODS: Seeds of Korean ginseng (Panax ginseng C...
July 2016: Cryo Letters
https://www.readbyqxmd.com/read/27924469/a-methylcellulose-and-collagen-based-temperature-responsive-hydrogel-promotes-encapsulated-stem-cell-viability-and-proliferation-in-vitro
#19
Christina Payne, Eimear B Dolan, Janice O'Sullivan, Sally-Ann Cryan, Helena M Kelly
With the number of stem cell-based therapies emerging on the increase, the need for novel and efficient delivery technologies to enable therapies to remain in damaged tissue and exert their therapeutic benefit for extended periods, has become a key requirement for their translation. Hydrogels, and in particular, thermoresponsive hydrogels, have the potential to act as such delivery systems. Thermoresponsive hydrogels, which are polymer solutions that transform into a gel upon a temperature increase, have a number of applications in the biomedical field due to their tendency to maintain a liquid state at room temperature, thereby enabling minimally invasive administration and a subsequent ability to form a robust gel upon heating to physiological temperature...
December 6, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27923698/engineered-sodium-hyaluronate-respirable-dry-powders-for-pulmonary-drug-delivery
#20
Francesco Martinelli, Anna Giulia Balducci, Abhinav Kumar, Fabio Sonvico, Ben Forbes, Ruggero Bettini, Francesca Buttini
Sodium hyaluronate (HYA) warrants attention as a material for inhalation due to its (i) therapeutic potential, (ii) utility as a formulation excipient or drug carrier, and (iii) ability to target lung inflammation and cancer. This study aimed to overcome formulation and manufacturing impediments to engineer biocompatible spray-dried HYA powders for inhalation. Novel methodology was developed to produce HYA microparticles by spray drying. Different types of surfactant were included in the formulation to improve powder respirability, which was evaluated in vitro using cascade impactors...
December 3, 2016: International Journal of Pharmaceutics
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