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https://www.readbyqxmd.com/read/28346743/fabrication-of-a-mechanically-anisotropic-poly-glycerol-sebacate-membrane-for-tissue-engineering
#1
Chi-Nung Hsu, Pei-Yuan Lee, Ho-Yi Tuan-Mu, Chen-Yu Li, Jin-Jia Hu
Poly(glycerol sebacate) (PGS) has been used successfully as a scaffolding material for soft tissue engineering. PGS scaffolds, however, are usually mechanically isotropic, which may restrict their use in tissue repairs as many soft tissues in the body have anisotropic mechanical behaviors. Although various methods have been used to fabricate anisotropic scaffolds, it remains challenging to make anisotropic scaffolds from thermoset PGS. Here a new, simple method to fabricate an anisotropic PGS membrane which can then be used to construct thicker three-dimensional anisotropic scaffolds was developed...
March 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28346388/thermal-condensation-of-glycine-and-alanine-on-metal-ferrite-surface-primitive-peptide-bond-formation-scenario
#2
Md Asif Iqubal, Rachana Sharma, Sohan Jheeta, Kamaluddin
The amino acid condensation reaction on a heterogeneous mineral surface has been regarded as one of the important pathways for peptide bond formation. Keeping this in view, we have studied the oligomerization of the simple amino acids, glycine and alanine, on nickel ferrite (NiFe₂O₄), cobalt ferrite (CoFe₂O₄), copper ferrite (CuFe₂O₄), zinc ferrite (ZnFe₂O₄), and manganese ferrite (MnFe₂O₄) nanoparticles surfaces, in the temperature range from 50-120 °C for 1-35 days, without applying any wetting/drying cycles...
March 27, 2017: Life
https://www.readbyqxmd.com/read/28345760/effect-of-temperature-on-lysosomal-enzyme-activity-during-preparation-and-storage-of-dried-blood-spots
#3
Manjunath Supriya, Tanima De, Rita Christopher
BACKGROUND: The use of dried blood spots (DBS) for the assay of lysosomal enzymes has facilitated the implementation of pilot studies for newborn screening for lysosomal storage disorders in various developed countries. The aim of the study was to determine the influence of ambient temperature during DBS preparation and storage on lysosomal enzyme activity in a developing, tropical country. METHODS: Blood samples from 12 healthy subjects collected on a S&S 903 filter paper were dried and stored at different temperatures for different periods of time...
March 27, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28345601/towards-reproducible-mrm-based-biomarker-discovery-using-dried-blood-spots
#4
Sureyya Ozcan, Jason D Cooper, Santiago G Lago, Diarmuid Kenny, Nitin Rustogi, Pawel Stocki, Sabine Bahn
There is an increasing interest in the use of dried blood spot (DBS) sampling and multiple reaction monitoring in proteomics. Although several groups have explored the utility of DBS by focusing on protein detection, the reproducibility of the approach and whether it can be used for biomarker discovery in high throughput studies is yet to be determined. We assessed the reproducibility of multiplexed targeted protein measurements in DBS compared to serum. Eighty-two medium to high abundance proteins were monitored in a number of technical and biological replicates...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345304/chemical-evidence-for-the-effect-of-urochloa-ruziziensis-on-glyphosate-resistant-soybeans
#5
Mariluce Nepomuceno, Nuria Chinchilla, Rosa M Varela, José M G Molinillo, Rodney Lacret, Pedro L C A Alves, Francisco A Macias
BACKGROUND: Soybean (Glycine max) is an important oleaginous legume that has been cultivated in new areas in Brazil, including pastures. Problems of reduced production yields have been reported by soybean growers when the crop is sown immediately after desiccation of pastures of Urochloa spp. using glyphosate. The objective of this work was to extract, isolate, and identify the major chemicals from U. ruziziensis that have phytotoxic activity and to evaluate the possible relation between this effect and the reduced soybean yield...
March 26, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28344632/dynamic-and-temporal-assessment-of-human-dried-blood-spot-ms-ms-all-shotgun-lipidomics-analysis
#6
Fei Gao, Justice McDaniel, Emily Y Chen, Hannah E Rockwell, Jeremy Drolet, Vivek K Vishnudas, Vladimir Tolstikov, Rangaprasad Sarangarajan, Niven R Narain, Michael A Kiebish
BACKGROUND: Real-time and dynamic assessment of an individual's lipid homeostatic state in blood is complicated due to the need to collect samples in a clinical environment. In the context of precision medicine and population health, tools that facilitate sample collection and empower the individual to participate in the process are necessary to complement advanced bioanalytical analysis. The dried blood spot (DBS) methodology via finger prick or heel prick is a minimally invasive sample collection method that allows the relative ease and low cost of sample collection as well as transport...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28344498/investigation-of-the-in-vitro-performance-difference-of-drug-soluplus%C3%A2-and-drug-peg-6000-dispersions-when-prepared-using-spray-drying-or-lyophilization
#7
Mohammad A Altamimi, Steven H Neau
PURPOSE: To evaluate the physicochemical and in vitro characteristics of solid dispersions using BCS II model drugs with Soluplus® and one of its component homopolymers, PEG 6000. METHODS: Nifedipine (NIF) and sulfamethoxazole (SMX) of 99.3% and 99.5% purity, respectively, were selected as BCS II model drugs, such that an improved dissolution rate and concentration in the gastrointestinal tract should increase oral bioavailability. Soluplus® is an amorphous, tri-block, graft co-polymer with polyvinyl caprolactam, polyvinyl acetate, and polyethylene glycol (PCL:PVAc:PEG6000) in the ratio 57:30:13...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28344493/volatile-constituents-and-biological-activities-of-the-leaf-and-root-of-echinacea-species-from-south-africa
#8
M Nyalambisa, I A Oyemitan, R Matewu, O O Oyedeji, O S Oluwafemi, S P Songca, B N Nkeh-Chungag, A O Oyedeji
Echinacea is used ethnomedicinally for the treatment of various diseases such as cough, respiratory infections, and bronchitis among other uses in Eastern Cape region of South Africa. This study evaluated the volatile components of the essential oil of the plant, its toxicity, anti-inflammatory and analgesic activities in rodents. Dried leaf and root of the plant were separately processed by hydrodistillation for 4 h and their essential oils (EOs) were collected. Extracted oils were subjected to GC/GC-MS analysis...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28344376/verification-measurements-of-the-irmm-1027-and-the-iaea-large-sized-dried-lsd-spikes
#9
R Jakopič, Y Aregbe, S Richter, E Zuleger, S Mialle, S D Balsley, U Repinc, J Hiess
In the frame of the accountancy measurements of the fissile materials, reliable determinations of the plutonium and uranium content in spent nuclear fuel are required to comply with international safeguards agreements. Large-sized dried (LSD) spikes of enriched (235)U and (239)Pu for isotope dilution mass spectrometry (IDMS) analysis are routinely applied in reprocessing plants for this purpose. A correct characterisation of these elements is a pre-requirement for achieving high accuracy in IDMS analyses. This paper will present the results of external verification measurements of such LSD spikes performed by the European Commission and the International Atomic Energy Agency...
2017: Journal of Radioanalytical and Nuclear Chemistry
https://www.readbyqxmd.com/read/28343360/tsunami-run-up-and-inundation-along-the-coast-of-sabah-and-sarawak-malaysia-due-to-a-potential-brunei-submarine-mass-failure
#10
Wai Kiat Tan, Su Yean Teh, Hock Lye Koh
Submarine landslides, also known as submarine mass failures (SMFs), are major natural marine disasters that could critically damage coastal facilities such as nuclear power plants and oil and gas platforms. It is therefore essential to investigate submarine landslides for potential tsunami hazard assessment. Three-dimensional seismic data from offshore Brunei have revealed a giant seabed mass deposited by a previous SMF. The submarine mass extends over 120 km from the continental slope of the Baram Canyon at 200 m water depth to the deep basin floor of the Northwest Borneo Trough...
March 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28343136/facile-microfluidic-production-of-composite-polymer-core-shell-microcapsules-and-crescent-shaped-microparticles
#11
Ekanem E Ekanem, Zilin Zhang, Goran T Vladisavljević
HYPOTHESIS: Core-shell microcapsules and crescent-shaped microparticles can be used as picolitre bioreactors for cell culture and microwells for cell trapping/immobilisation, respectively. RESULTS: Monodisperse polylactic acid (PLA) core-shell microcapsules with a diameter above 200μm, a shell thickness of 10μm, and 96% water entrapment efficiency were produced by solvent evaporation from microfluidically generated W/O/W emulsion drops with core-shell structure, and used to encapsulate Saccharomyces cerevisiae yeast cells in their aqueous cores...
March 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28343042/in-situ-determination-of-trace-elements-in-fucus-spp-by-field-portable-xrf
#12
Andrew Turner, Hiu Poon, Alex Taylor, Murray T Brown
Fresh and freeze-dried sample sections of the coastal macroalgae, Fucus serratus and F. vesiculosus, and the brackish water macroalga, F. ceranoides, have been analysed for trace elements by field-portable-X-ray fluorescence (FP-XRF) spectrometry using a Niton XL3t in a low density mode with thickness correction. When analysed fresh in a laboratory accessory stand for a period of 200 seconds, As, Br, Fe and Zn were registered in the apex, mid-frond and lower stipe of all species, with detection limits of a few μg g(-1) (As) or a few tens of μg g(-1) (Br, Fe, Zn); when analysed dry under the same conditions, concentrations returned were systematically higher and Cu and Pb were detected in a number of F...
March 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28342789/enhanced-gastric-stability-of-esomeprazole-by-molecular-interaction-and-modulation-of-microenvironmental-ph-with-alkalizers-in-solid-dispersion
#13
Hien Van Nguyen, Namhyun Baek, Beom-Jin Lee
Due to the instability of esomeprazole magnesium dihydrate (EPM), a proton pump inhibitor, in gastric fluid, enteric-coated dosage form is commonly used for therapeutic application. In this study, we prepared new gastric fluid resistant solid dispersions (SDs) containing alkalizers. Then, new mechanistic evidence regarding the effects of pharmaceutical alkalizers on the aqueous stability of EPM in simulated gastric fluid was investigated. The alkalizer-loaded SD were prepared by dissolving or dispersing EPM, hydroxypropyl methylcellulose (HPMC) 6 cps, and an alkalizer, in ethanol 50% (v/v) followed by spray drying...
March 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28342753/evaluation-of-chitosan-as-a-wall-material-for-microencapsulation-of-squalene-by-spray-drying-characterization-and-oxidative-stability-studies
#14
Lekshmi R G Kumar, N S Chatterjee, C S Tejpal, K V Vishnu, K K Anas, K K Asha, R Anandan, Suseela Mathew
The present study was aimed at investigating the efficacy of chitosan as a wall material for microencapsulation of squalene by spray drying for functional food applications. Based on different core to wall material ratio (1:1, 0.5:1 and 0.3:1 on w/w basis), emulsions were prepared and evaluated in terms of emulsion stability, particle size, zeta potential, polydispersity Index (PDI), rheology and microstructure. The optimized emulsion combination was spray dried and characterized, physically and chemically...
March 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28342414/impacts-of-soil-incorporation-of-pre-incubated-silica-rich-rice-residue-on-soil-biogeochemistry-and-greenhouse-gas-fluxes-under-flooding-and-drying
#15
Madison Y Gutekunst, Rodrigo Vargas, Angelia L Seyfferth
Incorporation of silica-rich rice husk residue into flooded paddy soil decreases arsenic uptake by rice. However, the impact of this practice on soil greenhouse gas (GHG) emissions and elemental cycling is unresolved particularly as amended soils experience recurrent flooding and drying cycles. We evaluated the impact of pre-incubated silica-rich rice residue incorporation to soils on pore water chemistry and soil GHG fluxes (i.e., CO2, CH4, N2O) over a flooding and drying cycle typical of flooded rice cultivation...
March 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28342405/validation-of-the-baking-process-as-a-kill-step-for-controlling-salmonella-in-muffins
#16
Lakshmikantha H Channaiah, Minto Michael, Jennifer C Acuff, Randall K Phebus, Harshavardhan Thippareddi, Maureen Olewnik, George Milliken
This research investigates the potential risk of Salmonella in muffins when contamination is introduced via flour, the main ingredient. Flour was inoculated with a 3-strain cocktail of Salmonella serovars (Newport, Typhimurium, and Senftenberg) and re-dried to achieve a target concentration of ~8logCFU/g. The inoculated flour was then used to prepare muffin batter following a standard commercial recipe. The survival of Salmonella during and after baking at 190.6°C for 21min was analyzed by plating samples on selective and injury-recovery media at regular intervals...
March 12, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28341976/development-and-evaluation-of-user-friendly-single-vial-dota-peptide-kit-formulations-specifically-designed-for-radiolabelling-with-68-ga-from-a-tin-dioxide-68-ge-68-ga-generator
#17
Deidré Prince, Daniel Rossouw, Claudia Davids, Sietske Rubow
PURPOSE: This study was aimed to develop single vial 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptide kits to be used with fractionated eluates from a SnO2-based (68)Ge/(68)Ga generator. PROCEDURES: Kits were formulated with 35 μg DOTA-Tyr(3)-Thre(8)-octreotide, DOTA-[Tyr(3)]-octreotide and DOTA-[NaI(3)]-octreotide (DOTATATE, DOTATOC and DOTANOC) and sodium acetate powder, vacuum-dried and stored at -20 °C for up to 12 months. Labelling of the kits was carried out with 2 ml (68)Ga eluate...
March 24, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28341935/a-natural-triterpenoid-saponin-as-multifunctional-stabilizer-for-drug-nanosuspension-powder
#18
Yingchong Chen, Yang Liu, Junnan Xu, Yuanbiao Xie, Qin Zheng, Pengfei Yue, Ming Yang
The objective of this study is to prepare a novel drug nanosuspension modified by a natural triterpenoid saponin (glycyrrhizin (GZ)) and evaluate its stability and redispersibility. A poorly soluble drug (andrographolide (AGE)) was used as a model drug. AGE nanosuspensions (AGE-NS) using GZ as natural stabilizer with mean particle size of 487 nm were firstly prepared by homogenization and converted into dried AGE nanosuspension powder (AGE-NP) by freeze-drying. It was found that GZ was able to prevent the aggregation of AGE nanocrystals and the freeze-dried AGE-NP could easily redisperse back to AGE-NS...
March 24, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28341779/cpap-adherence-a-matter-of-perfect-airflow-curves
#19
EDITORIAL
Dries Testelmans, Bertien Buyse
No abstract text is available yet for this article.
April 2017: Respiratory Care
https://www.readbyqxmd.com/read/28341598/lyophilized-drug-product-cake-appearance-what-is-acceptable
#20
Sajal Manubhai Patel, Steven L Nail, Michael J Pikal, Raimund Geidobler, Gerhard Winter, Andrea Hawe, Juan Davagnino, Shailaja Rambhatla Gupta
Cake appearance is an important attribute of freeze-dried products, which may or may not be critical with respect to product quality (i.e., safety and efficacy). Striving for "uniform and elegant" cake appearance may continue to remain an important goal during the design and development of a lyophilized drug product. However, sometimes a non-ideal cake appearance has no impact on product quality and is an inherent characteristic of the product (either due to formulation, drug product presentation and/or freeze-drying process)...
March 21, 2017: Journal of Pharmaceutical Sciences
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