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https://www.readbyqxmd.com/read/29793176/non-ldl-dyslipidemia-is-prevalent-in-the-young-and-determined-by-lifestyle-factors-and-age-the-lifelines-cohort
#1
Jeroen K de Vries, Jan W Balder, Michelle J Pena, Petra Denig, Andries J Smit
BACKGROUND AND AIMS: Non-LDL dyslipidemia (NLD) confers cardiovascular risk, and prevalence rates appear to be high in elderly populations. Small cohorts have identified several lifestyle, anthropometric, and medical factors associated with NLD. We aimed to assess sex- and age-specific prevalence of NLD in a contemporary population cohort (n = 167 729), and to identify independent determinants of NLD, focusing on lifestyle, anthropometric, and medical factors. METHODS: The prevalence of NLD was assessed per 10-year age intervals in adults without cardiovascular disease not using lipid-modifying drugs from the Dutch LifeLines cohort...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29792998/bmi-and-gender-increase-risk-for-sacral-fractures-after-multilevel-instrumented-spinal-fusion-compared-to-bone-mineral-density-and-pelvic-parameters
#2
Stephan N Salzmann, Courtney Ortiz Miller, John A Carrino, Jingyan Yang, Jennifer Shue, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
BACKGROUND CONTEXT: Sacral fractures are a rare but potentially devastating complication. Long-fusion constructs including the sacrum that do not extend to the pelvis may result in sacral fractures. Besides established risk factors including gender, age and number of levels fused, body mass index (BMI), pelvic parameters and bone mineral density (BMD) have also been proposed as potential risk factors for postoperative sacral fractures. The literature supporting this, however, is limited...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792567/effects-of-age-and-body-mass-index-on-breast-characteristics-a-cluster-analysis
#3
Celeste E Coltman, Julie R Steele, Deirdre E McGhee
Limited research has quantified variation in the characteristics of the breasts among women and determined how these breast characteristics are influenced by age and body mass. The aim of this study was to classify the breasts of women in the community into different categories based on comprehensive and objective measurements of the characteristics of their breasts and torsos, and to determine the effect of age and body mass index (BMI) on the prevalence of these breast categories. Four breast characteristic clusters were identified (X-Large, Very-ptotic & Splayed; Large, Ptotic & Splayed; Medium & Mildly-ptotic; and Small & Non-ptotic), with age and BMI shown to significantly affect the breast characteristic clusters...
May 24, 2018: Ergonomics
https://www.readbyqxmd.com/read/29792359/adverse-effect-analysis-of-high-intensity-focused-ultrasound-in-the-treatment-of-benign-uterine-diseases
#4
Yunchang Liu, Wendy Wenyi Zhang, Min He, Chunmei Gong, Bin Xie, Xiangxia Wen, Dandan Li, Lian Zhang
OBJECTIVE: To retrospectively analyze the adverse effects of high-intensity focused ultrasound (HIFU) in management of benign uterine diseases. MATERIALS AND METHODS: From 2011 to 2017, 27,053 patients with benign uterine diseases were treated with HIFU in 19 centers in China. Among them, 17,402 patients had uterine fibroids, 8434 had adenomyosis, 876 had caesarean scar pregnancies, and 341 had placenta accreta. RESULTS: The median age, height, weight, BMI of the patients was 42 years, 158 mm, 56 kg, 22...
May 24, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29792248/metataxonomic-analysis-of-individuals-at-bmi-extremes-and-monozygotic-twins-discordant-for-bmi
#5
Casey T Finnicum, Stieneke Doornweerd, Conor V Dolan, Justin M Luningham, Jeffrey J Beck, Gonneke Willemsen, Erik A Ehli, Dorret I Boomsma, Richard G Ijzerman, Gareth E Davies, Eco J C de Geus
OBJECTIVE: The human gut microbiota has been demonstrated to be associated with a number of host phenotypes, including obesity and a number of obesity-associated phenotypes. This study is aimed at further understanding and describing the relationship between the gut microbiota and obesity-associated measurements obtained from human participants. SUBJECTS/METHODS: Here, we utilize genetically informative study designs, including a four-corners design (extremes of genetic risk for BMI and of observed BMI; N = 50) and the BMI monozygotic (MZ) discordant twin pair design (N = 30), in order to help delineate the role of host genetics and the gut microbiota in the development of obesity...
June 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29792214/association-of-serum-bilirubin-level-with-lung-function-decline-a-korean-community-based-cohort-study
#6
Ah Young Leem, Ha Yan Kim, Young Sam Kim, Moo Suk Park, Joon Chang, Ji Ye Jung
BACKGROUND: Bilirubin has been reported to be associated with respiratory diseases due to its antioxidant action. We aimed to evaluate the relationship between serum bilirubin concentration and annual lung function decline in the Korean general population. METHODS: The study included 7986 subjects aged 40-69 years from the Ansung-Ansan cohort database I (2001-2002)-III (2005-2006). We analyzed the relationships between serum bilirubin level and forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC), FEV1 /FVC, and mean forced expiratory flow between 25 and 75% of FVC (FEF25-75% ) at baseline, as well as the annual average changes in these lung parameters...
May 23, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29792202/the-effects-of-a-lifestyle-focused-text-messaging-intervention-on-adherence-to-dietary-guideline-recommendations-in-patients-with-coronary-heart-disease-an-analysis-of-the-text-me-study
#7
Karla Santo, Karice Hyun, Laura de Keizer, Aravinda Thiagalingam, Graham S Hillis, John Chalmers, Julie Redfern, Clara K Chow
BACKGROUND: A healthy diet is an important component of secondary prevention of coronary heart disease (CHD). The TEXT ME study was a randomised clinical trial of people with CHD that were randomised into standard care or a text-message programme in addition to standard care. This analysis aimed to: 1) assess the effects of the intervention onadherence to the dietary guideline recommendations; 2) assess the consistency of effect across sub-groups; and 3) assess whether adherence to the dietary guideline recommendations mediated the improvements in objective clinical outcomes...
May 23, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29792070/chondral-delamination-of-fresh-osteochondral-allografts-after-implantation-in-the-knee-a-matched-cohort-analysis
#8
Ryan C Rauck, Dean Wang, Matthew Tao, Riley J Williams
Introduction Delamination of the chondral surface of an osteochondral allograft (OCA) from the underlying cancellous bone has been described as a mode of failure after implantation in the knee. Our hypothesis was that increased storage time of the OCA is associated with increased risk of graft delamination after implantation. Methods Prospective data on 13 patients with evidence of OCA delamination identified on magnetic resonance imaging or during subsequent surgery from 2000 to 2015 were reviewed. A cohort of 33 patients without evidence of graft delamination were then matched to the delamination group based on recipient age, sex, body mass index (BMI), and chondral defect location...
May 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29791654/maternal-hypothyroxinemia-in-the-first-trimester-of-gestation-and-association-with-obstetric-and-neonatal-outcomes-and-iron-deficiency-a-prospective-brazilian-study
#9
Pedro Weslley Rosario, Luis Fernando Faria Oliveira, Maria Regina Calsolari
OBJECTIVE: To evaluate the association of isolated hypothyroxinemia in the first trimester with obstetric and neonatal outcomes and iron deficiency. SUBJECTS AND METHODS: The study was prospective. Women who had become pregnant spontaneously were initially selected. Next, anti-thyroid peroxidase antibodies (TPOAb), free T4 (FT4), total T4 (TT4), TSH, and ferritin were measured. TPOAb-positive women were excluded. The final sample consisted of 596 women with serum TSH between 0...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791651/relationship-between-adiponectin-and-leptin-on-osteocalcin-in-obese-adolescents-during-weight-loss-therapy
#10
Raquel Munhoz da Silveira Campos, Deborah Cristina Landi Masquio, Flávia Campos Corgosinho, Joana Pereira de Carvalho-Ferreira, Bárbara Dal Molin Netto, Ana Paula Grotti Clemente, Lian Tock, Sergio Tufik, Marco Túlio de Mello, Ana Raimunda Dâmaso
OBJECTIVES: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. SUBJECTS AND METHODS: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791650/metabolic-syndrome-components-are-associated-with-oxidative-stress-in-overweight-and-obese-patients
#11
Nayara Rampazzo Morelli, Bruna Miglioranza Scavuzzi, Lucia Helena da Silva Miglioranza, Marcell Alysson Batisti Lozovoy, Andréa Name Colado Simão, Isaias Dichi
OBJECTIVE: The aim of this study is to evaluate the influence of the body mass index (BMI) and the metabolic syndrome (MetS) parameters on oxidative and nitrosative stress in overweight and obese subjects. SUBJECTS AND METHODS: Individuals were divided into three groups: the control group (G1, n = 131) with a BMI between 20 and 24.9 kg/m2, the overweight group (G2, n = 120) with a BMI between 25 and 29.9 kg/m2 and the obese group (G3, n = 79) with a BMI ≥ 30 kg/m2...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791465/predictors-of-subclinical-carotid-atherosclerosis-in-middle-aged-women
#12
Isly L de Barros, Laura Costa, Bento Bezerra, Rafael Gomes, Natanael Morais, Célia M C Strunz, Moacir Novaes, Otávio C E Gebara, Rodrigo Pinto Pedrosa, José C Nicolau
BACKGROUND: Traditional strategies for primary cardiovascular prevention have been insufficient in reducing the high rates of coronary ischemic events in women, probably because these women are often stratified into low-risk groups. However, cardiovascular diseases continue to be the main cause of morbidity and mortality in women worldwide. We hypothesized that carotid atherosclerosis (CA) is common in middle-aged women. METHODS: We prospectively evaluated asymptomatic peri- and post-menopausal women with no cardiovascular diseases or the use of hormone therapy from two gynecologic clinics...
2018: PloS One
https://www.readbyqxmd.com/read/29791453/the-association-between-food-insecurity-and-incident-type-2-diabetes-in-canada-a-population-based-cohort-study
#13
Christopher A Tait, Mary R L'Abbé, Peter M Smith, Laura C Rosella
BACKGROUND: A pervasive and persistent finding is the health disadvantage experienced by those in food insecure households. While clear associations have been identified between food insecurity and diabetes risk factors, less is known about the relationship between food insecurity and incident type 2 diabetes. The objective of this study is to investigate the association between household food insecurity and the future development of type 2 diabetes. METHODS: We used data from Ontario adult respondents to the 2004 Canadian Community Health Survey, linked to health administrative data (n = 4,739)...
2018: PloS One
https://www.readbyqxmd.com/read/29791439/multi-biomarker-disease-activity-score-as-a-predictor-of-disease-relapse-in-patients-with-rheumatoid-arthritis-stopping-tnf-inhibitor-treatment
#14
Marjan Ghiti Moghadam, Femke B G Lamers-Karnebeek, Harald E Vonkeman, Peter M Ten Klooster, Janneke Tekstra, Annemarie M Schilder, Henk Visser, Eric H Sasso, David Chernoff, Willem F Lems, Dirk-Jan van Schaardenburg, Robert Landewe, Hein J Bernelot Moens, Timothy R D J Radstake, Piet L C M van Riel, Mart A F J van de Laar, Tim L Jansen
OBJECTIVE: Successfully stopping or reducing treatment for patients with rheumatoid arthritis (RA) in low disease activity (LDA) may improve cost-effectiveness of care. We evaluated the multi-biomarker disease activity (MBDA) score as a predictor of disease relapse after discontinuation of TNF inhibitor (TNFi) treatment. METHODS: 439 RA patients who were randomized to stop TNFi treatment in the POET study were analyzed post-hoc. Three indicators of disease relapse were assessed over 12 months: 1) restarting TNFi treatment, 2) escalation of any DMARD therapy and 3) physician-reported flare...
2018: PloS One
https://www.readbyqxmd.com/read/29791170/effectiveness-and-safety-of-lixisenatide-for-treatment-of-diabetes-in-the-real-world-data-from-the-monitoring-registry-in-a-real-life-cohort-in-the-czech-and-slovak-republic
#15
Martin Haluzík, Alena Adamíková, Milan Běhunčík, Marek Macko, Radka Štěpánová
INTRODUCTION: GLP1 receptor agonist lixisenatide has demonstrated its efficacy in numerous clinical trials, nevertheless its real-life effectiveness data is limited. AIM: To describe effectiveness and safety of lixisenatide in routine clinical practice in the Czech Republic and the Slovak Republic, as recorded by the Registry-Based Observational Study. METHODS: Multinational, multicenter, observational, non-interventional, 6-month prospective product registry of patients with type 2 diabetes mellitus aged > 18 years who were initiating therapy with lixisenatide...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791055/high-birth-weight-was-associated-with-increased-radial-artery-intima-thickness-but-not-with-other-investigated-cardiovascular-risk-factors-in-adulthood
#16
I W Johnsson, T Naessén, F Ahlsson, J Gustafsson
AIM: This study investigated whether a high birth weight was associated with increased risk factors for cardiovascular disease when Swedish adults reached 34-40. METHODS: We studied 27 subjects born at Uppsala University Hospital in 1975-1979, weighing at least 4,500g, and compared them with 27 controls selected by the Swedish National Board of welfare with birth weights within ±1 standard deviations scores and similar ages and gender. The study included body mass index (BMI), blood pressure, lipid profile, haemoglobin A1c (HbA1c), C-reactive protein (CRP) and high frequency ultrasound measurements of intima-media thickness, intima thickness and intima:media ratio of the carotid and radial arteries...
May 23, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29790679/the-influence-of-a-3-week-body-mass-reduction-program-on-the-metabolic-parameters-and-free-amino-acid-profiles-in-adult-polish-people-with-obesity
#17
Małgorzata Moszak, Agnieszka Klupczyńska, Alina Kanikowska, Zenon Kokot, Agnieszka Zawada, Małgorzata Grzymisławska, Marian Grzymisławski
BACKGROUND: Previous studies have showed differences in the amino acid (AA) composition in the plasma of people with obesity when compared to lean individuals, but the perturbations of AA concentrations in obesity and the dynamics of AA changes after weight loss is not fully understood. OBJECTIVES: The objective of the study was to evaluate the effect of a short-term weight reduction program on the metabolic status and plasma AA levels in individuals with obesity...
April 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790672/prognostic-significance-of-combined-pretreatment-lymphocyte-counts-and-body-mass-index-in-patients-with-head-and-neck-cancer-treated-with-radiation-therapy
#18
Yao-Yu Wu, Kai-Ping Chang, Chien-Yu Lin, Ping-Ching Pai, Hung-Ming Wang, Cheng-Lung Hsu, Chun-Ta Liao, Tzu-Chen Yen, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Ku-Hao Fang, Wan-Ni Lin, Yu-Chien Wang, Li-Jen Hsin, Ngan-Ming Tsang
We aimed to investigate the prognostic significance of combined pretreatment lymphocyte counts (LCs) and body mass index (BMI) in patients with head and neck cancer (HNC) treated with radiation therapy (RT). Nine hundred and twelve patients with HNC who were treated with RT were retrospectively reviewed. Survival was analyzed by stratifying the patients according to pretreatment LCs and BMI. Patients with low pretreatment LCs and BMI were characterized by a more advanced T stage, fewer nasopharyngeal subsites, less smoking and drinking, and fewer comorbidities...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790669/genetically-determined-height-was-associated-with-lung-cancer-risk-in-east-asian-population
#19
Lu Wang, Mingtao Huang, Hui Ding, Guangfu Jin, Liang Chen, Feng Chen, Hongbing Shen
The association between adult height and risk of lung cancer has been investigated by epidemiology studies, but the results are inconsistent. Mendelian randomization (MR) analyses with individual-level data from two genome-wide association studies, including a total of 7127 lung cancer cases and 6818 controls, were carried out to explore whether adult height is causally associated with risk of lung cancer. A weighted genetic risk score (wGRS) was created based on genotypes of 101 known height-associated genetic variants...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790643/the-association-of-bicycle-related-genital-numbness-and-sexual-health-inventory-for-men-score-shim-results-from-a-large-multinational-cross-sectional-study
#20
Nima Baradaran, Mohannad Awad, Thomas W Gaither, Kirkpatrick B Fergus, Benjamin E Cedars, Ashwin S Balakrishnan, Michael L Eisenberg, Tom Sanford, Benjamin N Breyer
OBJECTIVE: To assess the association of genital numbness and erectile dysfunction in male cyclists. SUBJECTS AND METHODS: Cyclists were recruited through Facebook advertisements and outreach to sporting clubs. This is a secondary analysis of a larger epidemiologic population-based study that examined sexual and urinary wellness in athletes. We queried cycling habits and erectile function using Sexual Health Inventory for Men (SHIM). RESULTS: A total of 2,774 male cyclists were included for the analysis...
May 23, 2018: BJU International
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