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https://www.readbyqxmd.com/read/28231055/the-role-of-extracellular-vesicle-micrornas-in-cancer-biology
#1
Ryou-U Takahashi, Marta Prieto-Vila, Ai Hironaka, Takahiro Ochiya
MicroRNAs (miRNAs) constitute a large family of small, approximately 20-22 nucleotide non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Multiple studies report that miRNAs are involved in homeostatic maintenance and that aberrant expression of miRNAs is often observed in various types of diseases, including cancer. In cancer biology, miRNAs exert functional roles in tumor initiation, drug resistance, and metastasis. MiRNAs are also secreted through small vesicles called exosomes, which are endosome-derived vesicles derived from various cell types including immune and tumor cells...
February 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28230804/calcium-intake-and-nutritional-adequacy-in-spanish-children-the-aniva-study
#2
Nuria Rubio-López, Agustín Llopis-González, María Morales-Suárez-Varela
Calcium is an important nutrient for child development. The main objective of this study was to assess calcium intake and its adequacy with dietary reference intake (DRI) in Spanish children. The ANIVA (Antropometría y Nutrición Infantil de Valencia) study is a descriptive cross-sectional study. During two academic years 2013-2014 and 2014-2015, 1176 schoolchildren aged 6-9 years were selected from 14 primary schools in Valencia (Spain). Three-day food records were used to assess dietary intake, completed by parents/guardian...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28230456/off-label-prescribing-for-children-with-migraines-in-u-s-ambulatory-care-settings
#3
L Leanne Lai, Leroy Koh, Jane Ai-Chen Ho, Alexander Ting, Augustine Obi
BACKGROUND: Migraines, Which Affect About 10% Of School-Age Children In The United States, Can Significantly Impair Quality Of Life. Despite Potential Disability, Many Children Do Not Receive Treatment Or Prophylaxis, Since Medications Specifically Approved For Children Are Significantly Less Than For Adults. There Is Also Controversy Surrounding The Apparent Widespread Practice Of Prescribing Off-Label Medications For Children With Migraines. However, Little Research Has Been Done To Identify Physician-Prescribing Patterns Of Migraine Medication For Children...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28229357/experimental-determination-and-theoretical-calculation-of-the-eutectic-composition-of-cefuroxime-axetil-diastereomers
#4
Namita Dalal, Ira S Buckner, Peter L D Wildfong
Cefuroxime axetil (CFA), an ester prodrug of cefuroxime exists as a pair of diastereoemers, namely isomer A and isomer B. To enable phase diagram construction, crystallization of the diastereomers of CFA from the commercially available amorphous drug substance was carried out. Isomer A was separated with a purity approaching 100% whereas the maximum purity of isomer B was 85% as confirmed by solution state proton NMR spectroscopy. The crystalline forms of isomer A and isomer B were confirmed as forms AI and BI, respectively, based on differential scanning calorimetry (DSC) analysis and powder X-ray diffraction...
February 22, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28228779/a-retrospective-study-on-screening-and-management-of-osteoporosis-in-breast-cancer-women-treated-with-aromatase-inhibitors-in-libya
#5
Hanan Saaddedin Abushwereb, M Elhabash, S Elhamshari, H Eshaefi
Negative health effects of aromatase inhibitors (AI) treatments on bones such as osteoporosis are evidenced. This impact of the aromatase inhibitors on bone. This study aimed to improve the medical assistance given to patients under AI treatment to minimize secondary osteoporosis. Fifty Libyan postmenopausal women treated with AI to fight breast cancer were selected from attendants Tripoli Medical Center (TMC), Oncology Department during year 2014. A closed questionnaire was requested from each women including data about age, age at AI therapy, and types of AI, age at bone densitometry measurement, onset and symptoms of osteoporosis, treatment of osteoporosis and measurement of vitamin D and calcium supplement given...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28228659/mir-99a-suppresses-cell-invasion-and-metastasis-in-nasopharyngeal-carcinoma-through-targeting-hoxa1
#6
Jian-Gang Wang, Wu-Ping Tang, Ming-Chu Liao, Yan-Ping Liu, Xiao-Hong Ai
BACKGROUND: Recent studies reported that miRNAs play important roles in the carcinogenesis and progression of nasopharyngeal carcinoma (NPC). Therefore, further studies are warranted to better elucidate the function and mechanism of miRNAs in NPC. METHODS: Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the miR-99a expression in NPC cell lines and tissue samples. Wound healing, transwell migration and invasion, and lung metastatic colonization assays were performed to determine NPC cell migratory, invasive and metastatic abilities of NPC cells...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28228481/a-helical-bundle-in-the-n-terminal-domain-of-the-blm-helicase-mediates-dimer-and-potentially-hexamer-formation
#7
Jing Shi, Wei-Fei Chen, Bo Zhang, San-Hong Fan, Xia Ai, Na-Nv Liu, Stephane Rety, Xu-Guang Xi
Helicases play a critical role in processes such as replication or recombination by unwinding double-stranded DNA; mutations of these genes can therefore have devastating biological consequences. In human, mutations in genes of three members of the RecQ family helicases (blm, wrn and recq4) give rise to three strikingly distinctive clinical phenotypes: Bloom syndrome, Werner syndrome and Rothmund-Thomson syndrome, respectively. However, the molecular basis for these varying phenotypic outcomes is unclear, in part because a full mechanistic description of helicase activity is lacking...
February 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28228149/fasciolopsis-buski-digenea-fasciolidae-from-china-and-india-may-represent-distinct-taxa-based-on-mitochondrial-and-nuclear-ribosomal-dna-sequences
#8
Jun Ma, Miao-Miao Sun, Jun-Jun He, Guo-Hua Liu, Lin Ai, Mu-Xin Chen, Xing-Quan Zhu
BACKGROUND: Fasciolopsis buski is a zoonotic intestinal fluke infecting humans and pigs, but it has been seriously neglected. It is yet to know whether there is any genetic diversity among F. buski from different geographical locations, particularly in sequences of nuclear ribosomal DNA (rDNA) and mitochondrial (mt) DNA. Therefore, we determined the sequences of partial 18S, the complete internal transcribed spacer (ITS) rDNA and the complete mt genome of F. buski from China, compared the rDNA and mtDNA sequences with those of isolates from India and Vietnam, and assessed the phylogenetic relationships of this fluke and related fasciolid trematodes based on the mtDNA dataset...
February 22, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28227366/automated-in-vivo-3d-high-definition-optical-coherence-tomography-skin-analysis-system
#9
Ai Ping Yow, Jun Cheng, Annan Li, Ruchir Srivastava, Jiang Liu, Damon Wing Kee Wong, Hong Liang Tey, Ai Ping Yow, Jun Cheng, Annan Li, Ruchir Srivastava, Jiang Liu, Damon Wing Kee Wong, Hong Liang Tey, Ai Ping Yow, Jiang Liu, Annan Li, Hong Liang Tey, Jun Cheng, Ruchir Srivastava
The in vivo assessment and visualization of skin structures can be performed through the use of high resolution optical coherence tomography imaging, also known as HD-OCT. However, the manual assessment of such images can be exhaustive and time consuming. In this paper, we present an analysis system to automatically identify and quantify the skin characteristics such as the topography of the surface of the skin and thickness of the epidermis in HD-OCT images. Comparison of this system with manual clinical measurements demonstrated its potential for automatic objective skin analysis and diseases diagnosis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227121/automated-basal-cell-carcinoma-detection-in-high-definition-optical-coherence-tomography
#10
Annan Li, Jun Cheng, Ai Ping Yow, Ruchir Srivastava, Damon Wing Kee Wong, Hong Liang Tey, Jiang Liu, Annan Li, Jun Cheng, Ai Ping Yow, Ruchir Srivastava, Damon Wing Kee Wong, Hong Liang Tey, Jiang Liu, Ai Ping Yow, Jiang Liu, Annan Li, Hong Liang Tey, Jun Cheng, Ruchir Srivastava
Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. Conventional diagnosis of BCC requires invasive biopsies. Recently, a high-definition optical coherence tomography (HD-OCT) technique has been developed, which provides a non-invasive in vivo imaging method of skin. Good agreements of BCC features between HD-OCT images and histopathological architecture have been found. Therefore it is possible to automatically detect BCC using HD-OCT. This paper presents a novel BCC detection method that consists of four steps: graph based skin surface segmentation, surface flattening, deep feature extraction and the BCC classification...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226851/transcranial-focused-ultrasound-for-bold-fmri-signal-modulation-in-humans
#11
Leo Ai, Jerel K Mueller, Andrea Grant, Yigitcan Eryaman, Wynn Legon, Leo Ai, Jerel K Mueller, Andrea Grant, Yigitcan Eryaman, Wynn Legon, Andrea Grant, Wynn Legon, Yigitcan Eryaman, Leo Ai, Jerel K Mueller
Transcranial focused ultrasound (tFUS) is an emerging form of non-surgical human neuromodulation that confers advantages over existing electro and electromagnetic technologies by providing a superior spatial resolution on the millimeter scale as well as the capability to target sub-cortical structures non-invasively. An examination of the pairing of tFUS and blood oxygen level dependent (BOLD) functional MRI (fMRI) in humans is presented here.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226753/determining-the-difference-in-eyegaze-measurements-in-individuals-with-age-related-macular-degeneration
#12
Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Augustinus Laude, Huiying Liu, Tock Han Lim, Fengshou Yin, Yanwu Xu, Damon Wong, Ai Ping Yow
Age-related Macular Degeneration (AMD) is one of the leading causes of blindness in the elderly. Visual loss associated with AMD often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods of detecting AMD are typically manual, require holding fixation and an external response trigger. In this paper, we propose the use of eyegaze tracking to detect for the presence of AMD, using a simple set of test patterns. Experimental results show that the derived eyegaze measurements can help to identify individuals with AMD from healthy individuals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226611/beat-to-beat-variability-of-p-wave-in-patients-suffering-from-atrial-fibrillation
#13
Federica Censi, Giovanni Calcagnini, Eugenio Mattei, Alessandro Ricci, Ivan Corazza, Elisa Reggiani, Giuseppe Boriani, Federica Censi, Giovanni Calcagnini, Eugenio Mattei, Alessandro Ricci, Ivan Corazza, Elisa Reggiani, Giuseppe Boriani, Elisa Reggiani, Giuseppe Boriani, Ivan Corazza, Alessandro Ricci, Federica Censi, Eugenio Mattei, Giovanni Calcagnini
The aim of this paper was to analyze the P-wave variability over time in patients suffering from Atrial Fibrillation (AF). Behind some time-domain and morphological features of the P-wave template, two novel indexes of P-wave variability have been estimated: one based on the cross-correlation coefficients among the P-waves (Correlation Index, CI), and one associated to variation of P-waves amplitude (Amplitude Index, AI). These indexes were estimated in two experimental models: patients suffering from persistent AF respect to control subjects and patients developing post-operative AF (POAF) after coronary artery bypass grafting respect to patients without POAF...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225890/the-anesthetic-agent-sevoflurane-attenuates-pulmonary-acute-lung-injury-by-modulating-apoptotic-pathways
#14
L Wang, Y Ye, H B Su, J P Yang
The objective of this study was to evaluate lung protection by the volatile anesthetic sevoflurane (SEVO), which inhibits apoptosis. Male Sprague-Dawley rats (250-280 g; n=18) were randomly divided into three groups. The LPS group received 5 mg/kg endotoxin (lipopolysaccharide), which induced acute lung injury (ALI). The control (CTRL) group received normal saline and the SEVO group received sevoflurane (2.5%) for 30 min after ALI was induced by 5 mg/kg LPS. Samples were collected for analysis 12 h after LPS...
February 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28224796/multi-cl-substituted-self-assembled-molecules-as-anode-interlayers-tuning-surface-properties-and-humidity-stability-for-organic-photovoltaics
#15
Xiaofang Cheng, Liqiang Huang, Lifu Zhang, Qingyun Ai, Lie Chen, Yiwang Chen
Self-assembled small-molecules (SASMs) are of effective materials to improve the interfacial issues between the metal/metal oxide and the overlying organic layer. In this work, surface modification of indium tin oxide (ITO) electrode through a series of Cl-contained SASMs has been exploited to control the surface properties of ITO and device performance in organic photovoltaics. Depending on the position and degrees of chlorination for SASMs, we could precisely manipulate the work function of the ITO electrode, and chemisorption of SASMs on ITO as well...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28224427/clinical-characteristics-of-sleep-disorders-in-patients-with-parkinson-s-disease
#16
Zhi-Juan Mao, Chan-Chan Liu, Su-Qiong Ji, Qing-Mei Yang, Hong-Xiang Ye, Hai-Yan Han, Zheng Xue
In order to investigate the sleep quality and influencing factors in patients with Parkinson's disease (PD), 201 PD patients were enrolled and underwent extensive clinical evaluations. Subjective sleep evaluation was assessed using the Pittsburgh Sleep Quality Index (PSQI), and the Epworth Sleepiness Scale (ESS). It was found that poor sleep quality (77.11%) and excessive daytime sleepiness (32.34%) were commonly seen in PD patients and positively correlated with disease severity. Then 70 out of the 201 PD patients and 70 age- and sex-matched controls underwent a polysomnographic recording...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28224149/two-new-metal-organic-frameworks-based-on-tetrazole-heterocyclic-ligands-accompanied-by-in-situ-ligand-formation
#17
Qin Li, Mei-Hui Yu, Jian Xu, Ai-Lin Li, Tong-Liang Hu, Xian-He Bu
Based on the same in situ formed ligand, two new MOFs, namely {[Zn2(HL)2]·0.5DMF·H2O}n (1) and {[Cd2(HL)2]·1.5H2O}n (2) (H3L = 5-[(2H-tetrazol-5-yl)amino]isophthalic acid), have been solvothermally synthesized and structurally characterized by elemental analysis, IR, PXRD, and single-crystal X-ray diffraction. During the self-assembly process, the original ligand H2ATBDC (5-(5-amino-1H-tetrazol-1-yl)-1,3-benzenedicarboxylic acid) undergoes the Dimroth rearrangement to form a new ligand H3L, consequently contributing to the construction of the two new MOFs...
February 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28223732/effects-of-sex-and-generation-on-hepatitis-b-viral-load-in-families-with-hepatocellular-carcinoma
#18
Ai-Ru Hsieh, Cathy Sj Fann, Chau-Ting Yeh, Hung-Chun Lin, Shy-Yi Wan, Yi-Cheng Chen, Chia-Lin Hsu, Jennifer Tai, Shi-Ming Lin, Dar-In Tai
AIM: To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives. METHODS: We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structured questionnaire...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28223265/use-of-a-novel-artificial-intelligence-platform-on-mobile-devices-to-assess-dosing-compliance-in-a-phase-2-clinical-trial-in-subjects-with-schizophrenia
#19
Earle E Bain, Laura Shafner, David P Walling, Ahmed A Othman, Christy Chuang-Stein, John Hinkle, Adam Hanina
BACKGROUND: Accurately monitoring and collecting drug adherence data can allow for better understanding and interpretation of the outcomes of clinical trials. Most clinical trials use a combination of pill counts and self-reported data to measure drug adherence, despite the drawbacks of relying on these types of indirect measures. It is assumed that doses are taken, but the exact timing of these events is often incomplete and imprecise. OBJECTIVE: The objective of this pilot study was to evaluate the use of a novel artificial intelligence (AI) platform (AiCure) on mobile devices for measuring medication adherence, compared with modified directly observed therapy (mDOT) in a substudy of a Phase 2 trial of the α7 nicotinic receptor agonist (ABT-126) in subjects with schizophrenia...
February 21, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28223239/anterior-insula-signals-inequalities-in-a-modified-ultimatum-game
#20
Xuemei Cheng, Li Zheng, Lin Li, Yijie Zheng, Xiuyan Guo, Guang Yang
Studies employing the Ultimatum Game (UG) which involves two parties (i.e., proposers and responders) splitting some money have suggested the role that anterior insula (AI) plays in detecting fairness norm violation, i.e., violation of the responder's expectation of receiving equal splits from the proposer. In this study, we explored how AI would respond when there existed simultaneously another expectation of being treated equivalently as others. Participants acted as responders and would be informed about both the offers they received and the average amount of money the same proposer offered to others...
February 18, 2017: Neuroscience
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