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https://www.readbyqxmd.com/read/28944809/plasmonic-sensor-with-high-figure-of-merit-based-on-differential-polarization-spectra-of-elliptical-nanohole-array
#1
Bin Ai, Pradip Basnet, Steven Larson, Whitney Ingram, Yiping Zhao
Using the difference of the polarization transmission spectra of elliptical nanohole arrays (ENAs), the figure of merit (FOM) of the sensor performance of ENA can be significantly improved, and is inversely proportional to the measurement resolution. By optimizing the aspect ratio of the elliptical holes, Ag thickness, substrate-effect, and adhesive layer, the sensitivity, FOM, and relative sensitivity of the ENA can be improved to be 775 nm RIU(-1), 705 RIU(-1), and 70.23%, respectively, with an excellent linear dependence on the change of refractive index...
September 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28944478/invasive-alien-plants-benefit-more-from-clonal-integration-in-heterogeneous-environments-than-natives
#2
Yong-Jian Wang, Heinz Müller-Schärer, Mark van Kleunen, Ai-Ming Cai, Ping Zhang, Rong Yan, Bi-Cheng Dong, Fei-Hai Yu
What confers invasive alien plants a competitive advantage over native plants remains open to debate. Many of the world's worst invasive alien plants are clonal and able to share resources within clones (clonal integration), particularly in heterogeneous environments. Here, we tested the hypothesis that clonal integration benefits invasive clonal plants more than natives and thus confers invasives a competitive advantage. We selected five congeneric and naturally co-occurring pairs of invasive alien and native clonal plants in China, and grew pairs of connected and disconnected ramets under heterogeneous light, soil nutrient and water conditions that are commonly encountered by alien plants during their invasion into new areas...
September 25, 2017: New Phytologist
https://www.readbyqxmd.com/read/28944471/a-composite-of-exhaled-ltb4-lxa4-feno-and-fev1-as-an-asthma-classification-ratio-characterizes-childhood-asthma
#3
Li-Chen Chen, Hsu-Min Tseng, Ming-Ling Kuo, Chih-Yung Chiu, Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Ai-Hsuan Wu, Jing-Long Huang, Shau-Ku Huang
BACKGROUND: Aberrant generation of eicosanoids is associated with asthma, but the evidence remains incomplete and its potential utility as biomarkers is unclear. Major eicosanoids in exhaled breath condensates (EBCs) were assessed as candidate markers for childhood asthma. METHODS: Ten exhaled eicosanoid species was evaluated using ELISA in the discovery phase, followed by prediction model-building and validation phases. RESULTS: Exhaled LTB4 , LTE4 , PGE2 and LXA4 showed significant difference between asthmatics (N=60) and controls (N=20)...
September 25, 2017: Allergy
https://www.readbyqxmd.com/read/28944203/systematic-review-and-meta-analysis-comparing-modified-cross-linking-and-standard-cross-linking-for-progressive-keratoconus
#4
Yang Liu, Yi Liu, Ying-Nan Zhang, Ai-Peng Li, Jing Zhang, Qing-Feng Liang, Ying Jie, Zhi-Qiang Pan
AIM: To compare the effectiveness and safety between modified cross-linking (MC) and standard cross-linking (SC) in mild or moderate progressive keratoconus. METHODS: Eligible studies were retrieved from four electronic databases, including CENTRAL, Clinical Trials gov, PupMed and OVID MEDLINE. We set post-surgical maximum K value (Kmax) as the primary outcome. In addition, uncorrected and corrected distant visual acuity (UDVA and UDVA), spherical equivalent (SE), endothelial cell density (ECD), central cornea thickness (CCT) and depth of demarcation line (DDL) were Meta-analyzed as secondary outcomes...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28943963/expression-of-the-tumor-suppressor-gene-p16-and-lymph-node-metastasis-in-patients-with-ovarian-cancer
#5
Hongyan Wang, Jingfang Zheng, Qiang Li, Min Zhou, Dongmei Ai, Hui Zhang
This study examined the relationship between the expression of p16, a tumor suppressor gene, and lymph node metastasis, as well as patient prognosis, in cases with ovarian cancer. SKOV-3, an ovarian cancer cell line, and IOSE80, a normal human ovarian cell line, were selected for testing. Western blot analysis was used to detect the p16 expression in ovarian cell culture samples. In the study, 20 cases with normal ovarian tissue and 64 cases with ovarian cancer tissue, including 38 cases with lymph node metastasis and 26 cases without lymph node metastasis, were also selected for testing...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943903/high-expression-of-gp73-in-primary-hepatocellular-carcinoma-and-its-function-in-the-assessment-of-transcatheter-arterial-chemoembolization
#6
Ning Ai, Wei Liu, Zhi-Gang Li, Hong Ji, Bo Li, Guang Yang
Golgi glycoprotein 73 (GP73) is a type II Golgi transmembrane protein and a potential novel marker for the diagnosis of primary hepatocellular carcinoma (PHC). However, its reliability as a serum marker for the diagnosis of PHC following transcatheter arterial chemoembolization (TACE) remains unknown. The aim of the present study was to evaluate the diagnostic value of serum GP73 levels in patients with PHC, to determine its diagnostic accuracy in patients with PHC following TACE. Reverse transcription-quantitative polymerase chain reaction analysis was used to measure GP73 expression in PHC and adjacent para-carcinomatous liver tissue in 40 patients with PHC, and 15 normal liver samples from benign hepatic tumors...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943782/the-bsm-ai-project-susy-ai-generalizing-lhc-limits-on-supersymmetry-with-machine-learning
#7
Sascha Caron, Jong Soo Kim, Krzysztof Rolbiecki, Roberto Ruiz de Austri, Bob Stienen
A key research question at the Large Hadron Collider is the test of models of new physics. Testing if a particular parameter set of such a model is excluded by LHC data is a challenge: it requires time consuming generation of scattering events, simulation of the detector response, event reconstruction, cross section calculations and analysis code to test against several hundred signal regions defined by the ATLAS and CMS experiments. In the BSM-AI project we approach this challenge with a new idea. A machine learning tool is devised to predict within a fraction of a millisecond if a model is excluded or not directly from the model parameters...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28943568/unilateral-oculomotor-nerve-palsy-following-campylobacter-infection-a-mild-form-of-miller-fisher-syndrome-without-ataxia
#8
Tatsuya Ueno, Tomoya Kon, Ai-Ichiro Kurihara, Masahiko Tomiyama
Unilateral oculomotor nerve palsy can result from various neurological disorders. We herein report the case of a 68-year-old man with complete unilateral oculomotor nerve palsy following campylobacter infection. Based on the antecedent infection and the patient's decreased tendon reflexes, incomplete Miller Fisher syndrome (MFS) without ataxia was suspected. His serum tested positive for anti-GQ1b antibodies. He recovered over a period of 87 days without immunotherapy. We conclude that incomplete MFS following campylobacter infection can cause unilateral oculomotor nerve palsy without ataxia...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943315/nlrp3-phosphorylation-is-an-essential-priming-event-for-inflammasome-activation
#9
Nan Song, Zhao-Shan Liu, Wen Xue, Zhao-Fang Bai, Qian-Yi Wang, Jiang Dai, Xin Liu, Yi-Jiao Huang, Hong Cai, Xiao-Yan Zhan, Qiu-Ying Han, Hongxia Wang, Yuan Chen, Hui-Yan Li, Ai-Ling Li, Xue-Min Zhang, Tao Zhou, Tao Li
Many infections and stress signals can rapidly activate the NLRP3 inflammasome to elicit robust inflammatory responses. This activation requires a priming step, which is thought to be mainly for upregulating NLRP3 transcription. However, recent studies report that the NLRP3 inflammasome can be activated independently of transcription, suggesting that the priming process has unknown essential regulatory steps. Here, we report that JNK1-mediated NLRP3 phosphorylation at S194 is a critical priming event and is essential for NLRP3 inflammasome activation...
September 19, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28943268/regulated-efflux-of-photoreceptor-outer-segment-derived-cholesterol-by-human-rpe-cells
#10
Federica Storti, Gabriele Raphael, Vera Griesser, Katrin Klee, Faye Drawnel, Carolin Willburger, Rebecca Scholz, Thomas Langmann, Arnold von Eckardstein, Jürgen Fingerle, Christian Grimm, Cyrille Maugeais
Genetic studies have linked age-related macular degeneration (AMD) to genes involved in high-density lipoprotein (HDL) metabolism, including ATP-binding cassette transporter A1 (ABCA1). The retinal pigment epithelium (RPE) handles large amounts of lipids, among others cholesterol, partially derived from internalized photoreceptor outer segments (OS) and lipids physiologically accumulate in the aging eye. To analyze the potential function of ABCA1 in the eye, we measured cholesterol efflux, the first step of HDL generation, in RPE cells...
September 21, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28942193/identification-of-novel-nrf2-activators-from-cinnamomum-chartophyllum-h-w-li-and-their-potential-application-of-preventing-oxidative-insults-in-human-lung-epithelial-cells
#11
Ming-Xing Zhou, Guo-Hui Li, Bin Sun, You-Wei Xu, Ai-Ling Li, Yan-Ru Li, Dong-Mei Ren, Xiao-Ning Wang, Xue-Sen Wen, Hong-Xiang Lou, Tao Shen
Human lung tissue, directly exposed to the environmental oxidants and toxicants, is apt to be harmed to bring about acute or chronic oxidative insults. The nuclear factor erythroid 2-related factor 2 (Nrf2) represents a central cellular defense mechanism, and is a target for developing agents against oxidative insult-induced human lung diseases. Our previous study found that the EtOH extract of Cinnamomum chartophyllum protected human bronchial epithelial cells against oxidative insults via Nrf2 activation...
September 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28941819/characterization-of-anogenital-distance-and-its-relationship-to-fertility-in-lactating-holstein-cows
#12
M Gobikrushanth, T C Bruinjé, M G Colazo, S T Butler, D J Ambrose
Anogenital distance (AGD) serves as a marker for prenatal androgenization, reproductive development, and fertility in humans and rodents. The primary objectives of this observational study in lactating dairy cows were to (1) characterize the distribution and variability of AGD, (2) determine the relationship among AGD and potential postnatal AGD determinants of age and height, and (3) evaluate the associations between AGD and pregnancy to first artificial insemination (P/AI) and cumulative pregnancy by 250 d in milk (DIM) within parity groups (first, second, and third+ parities)...
September 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28941408/boar-seminal-plasma-inhibits-cryo-capacitation-of-frozen-thawed-ram-sperm-and-improves-fertility-following-intracervical-insemination
#13
Yi Fang, Rongzhen Zhong, Xiaosheng Zhang, Jinlong Zhang, Daowei Zhou
Cryopreservation has numerous deleterious effects on sperm structure and function, which can be reduced by adding seminal plasma (SP), either autologous or heterologous. The objective was to determine effects of adding boar SP to the freezing extender on sperm quality, tyrosine phosphorylation and fertilizing ability of frozen-thawed ram sperm. Semen was collected from eight Small-tail Han rams and extended in a glucose-egg yolk buffer supplemented with 0, 20, 40, or 60% porcine SP (from Large white boars)...
September 18, 2017: Theriogenology
https://www.readbyqxmd.com/read/28941389/vitamin-a-nutritional-status-in-high-and-low-income-postpartum-women-and-its-effect-on-colostrum-and-the-requirements-of-the-term-newborn
#14
Cristiane Santos Sânzio Gurgel, Evellyn C Grilo, Larissa Q Lira, Débora G F Assunção, Priscila G Oliveira, Larisse R M de Melo, Silvia V de Medeiros, Luanna C Pessanha, Roberto Dimenstein, Clélia O Lyra
OBJECTIVE: To evaluate the vitamin A status in serum and colostrum of postpartum women with different socioeconomic status, comparing the colostrum retinol supply with the vitamin A requirement of the newborn. METHODS: Cross-sectional study conducted with 424 postpartum women. Vitamin A maternal dietary intake was estimated using a food frequency questionnaire. Colostrum and serum retinol levels were measured by high performance liquid chromatography (HPLC). Serum retinol concentrations <20μg/dL were indicative of vitamin A deficiency (VAD)...
September 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28941295/the-roles-of-interleukin-1-and-rhoa-signaling-pathway-in-rat-epilepsy-model-treated-with-low-frequency-electrical-stimulation
#15
Ai-Hua Liu, Ya-Ting Wu, Li-Ping Li, Yu-Ping Wang
This study aims to explore the correlation between interleukin-1 (IL-1) and epilepsy in rats when treated with low-frequency electrical stimulation via the RhoA/ROCK signaling pathway. Twenty-four SD rats were elected for this study, among which six rats were assigned as the normal group. And 16 rat models with epilepsy were successfully established and assigned into the model group, the ES group and the ES + IL-8 group, with each group comprising of six rats. The seizure frequency and duration was recorded...
September 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28941131/promoting-sketching-in-introductory-geoscience-courses-cogsketch-geoscience-worksheets
#16
Bridget Garnier, Maria Chang, Carol Ormand, Bryan Matlen, Basil Tikoff, Thomas F Shipley
Research from cognitive science and geoscience education has shown that sketching can improve spatial thinking skills and facilitate solving spatially complex problems. Yet sketching is rarely implemented in introductory geosciences courses, due to time needed to grade sketches and lack of materials that incorporate cognitive science research. Here, we report a design-centered, collaborative effort, between geoscientists, cognitive scientists, and artificial intelligence (AI) researchers, to characterize spatial learning challenges in geoscience and to design sketch activities that use a sketch-understanding program, CogSketch...
September 23, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/28940847/genetic-mapping-using-1-4m-snp-array-refined-loci-for-fatty-acid-composition-traits-in-chinese-erhualian-and-bamaxiang-pigs
#17
J Zhang, Y Zhang, H Gong, L Cui, T Huang, H Ai, J Ren, L Huang, B Yang
Chinese indigenous pigs display marked genetic and phenotypic differences compared with western commercial pigs. In this study, we tested the association between 660K SNPs and longissimus muscle fatty acid composition traits in Chinese Erhualian (n = 331) and Bamaxiang (n = 315) pigs based on a customized 1.4 million SNP array. We identified a total of 64 significant associations for 20 fatty acid composition traits at the p-value threshold of 1 × 10(-6) among which 42 associations in low linkage disequilibrium (r(2 ) < ...
September 20, 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28940594/characteristics-of-bioelectrical-activity-of-oviducts-and-uterus-during-early-pregnancy-in-sows-recorded-by-telemetry-method
#18
Bartosz Pawlinski, Malgorzata Domino, Romuald Zabielski, Katarzyna Siewruk, Malgorzata Polanska-Plachta, Zdzislaw Gajewski
The aim of the present study was to record the myoelectric activity of the reproduction tract in sows during the estrous phase and the early pregnancy period via telemetry recording system. In a total of eight non-pregnant pigs, the bioelectrical activity was recorded through three silicone electrodes sutured on the oviduct (isthmus and ampulla) and the uterine horn. Blood samples were collected to monitor the levels of progesterone (P4) and luteinizing hormone (LH). The estrous cycle was synchronized with eCG and hCG and the animals were subjected to artificial insemination (AI)...
September 21, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28940498/twice-weekly-pulse-and-daily-continuous-dose-erlotinib-as-initial-treatment-for-patients-with-epidermal-growth-factor-receptor-mutant-lung-cancers-and-brain-metastases
#19
Kathryn C Arbour, Mark G Kris, Gregory J Riely, Ai Ni, Kathryn Beal, Mariza Daras, Sara A Hayes, Robert J Young, Christopher R Rodriguez, Linda Ahn, William Pao, Helena A Yu
BACKGROUND: In a phase 1 study of pulse/continuous-dose erlotinib, no patient had disease progression in the central nervous system (CNS). This expansion cohort of the phase 1 study tested the same regimen in a cohort of individuals with epidermal growth factor receptor (EGFR)-mutant lung cancers with untreated brain metastases. METHODS: Patients had not received EGFR tyrosine kinase inhibitors or radiation for brain metastases. All received 1200 mg of erlotinib on days 1 and 2 and 50 mg on days 3 to 7 weekly...
September 21, 2017: Cancer
https://www.readbyqxmd.com/read/28940111/hyperuricemia-is-associated-with-increased-apo-ai-fractional-catabolic-rates-and-dysfunctional-hdl-in-new-zealand-rabbits
#20
Miriam Martínez-Ramírez, Cristóbal Flores-Castillo, L Gabriela Sánchez-Lozada, Rocío Bautista-Pérez, Elizabeth Carreón-Torres, José Manuel Fragoso, José Manuel Rodriguez-Pérez, Fernando E García-Arroyo, Victoria López-Olmos, María Luna-Luna, Gilberto Vargas-Alarcón, Martha Franco, Oscar Pérez-Méndez
The potential cause-effect relationship between uric acid plasma concentrations and HDL functionality remains elusive. Therefore, this study aimed to explore the effect of oxonic acid (OA)-induced hyperuricemia on the HDL size distribution, lipid content of HDL subclasses, and apo AI turnover, as well as HDL functionality in New Zealand white rabbits. Experimental animals received OA 750 mg/kg/day by oral gavage during 21 days. The HDL-apo AI fractional catabolic rate (FCR) was determined by exogenous labeling with (125)I, and HDL subclasses were determined by sequential ultracentrifugation and PAGE...
September 22, 2017: Lipids
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