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https://www.readbyqxmd.com/read/29346410/an-evaluation-of-multi-probe-locality-sensitive-hashing-for-computing-similarities-over-web-scale-query-logs
#1
Graham Cormode, Anirban Dasgupta, Amit Goyal, Chi Hoon Lee
Many modern applications of AI such as web search, mobile browsing, image processing, and natural language processing rely on finding similar items from a large database of complex objects. Due to the very large scale of data involved (e.g., users' queries from commercial search engines), computing such near or nearest neighbors is a non-trivial task, as the computational cost grows significantly with the number of items. To address this challenge, we adopt Locality Sensitive Hashing (a.k.a, LSH) methods and evaluate four variants in a distributed computing environment (specifically, Hadoop)...
2018: PloS One
https://www.readbyqxmd.com/read/29345673/china-s-ai-dreams
#2
Owen Churchill
No abstract text is available yet for this article.
January 18, 2018: Nature
https://www.readbyqxmd.com/read/29345655/china-enters-the-battle-for-ai-talent
#3
David Cyranoski
No abstract text is available yet for this article.
January 18, 2018: Nature
https://www.readbyqxmd.com/read/29345520/correlates-of-physical-activity-among-middle-aged-and-older-adults-with-hazardous-drinking-habits-in-six-low-and-middle-income-countries
#4
Davy Vancampfort, Brendon Stubbs, Mats Hallgren, Andreas Lundin, James Mugisha, Ai Koyanagi
We investigated physical activity (PA) correlates among middle-aged and older adults (aged ≥50 years) with hazardous drinking patterns in six low-and-middle-income countries (LMICs). Cross-sectional data were analyzed from the World Health Organization's Study on Global Ageing and Adult Health. Hazardous drinking was defined as consuming >7 (females) or >14 (males) standard drinks per week. Participants were dichotomized into low (i.e. not meeting 150 minutes of moderate PA / week) and moderate-to-high physically active groups...
January 18, 2018: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/29345480/psychometric-evaluation-of-depression-measures-with-northern-plains-indians
#5
Jacqueline S Gray, Julio Brionez, Thomas Petros, Kevin T Gonzaga
Numerous psychometric measurements are used to assess for mental health problems in Native American and Alaskan Native (AI/AN) populations; however, few studies have been carried out to assess their validity and reliability within these populations. This study was designed to assess the validity and reliability of numerous measures among the Northern Plains Indians. This article is a partial report, focused on the psychometric measures directed at detecting depression, namely the Beck Depression Inventory (BDI) II, the Center for Epidemiologic Studies Depression (CES-D) Scale, the Tri-Ethnic Depression Scale (TEDS), the Beck Hopelessness Scale (BHS), the Beck Anxiety Inventory (BAI), and the Symptom Checklist-90-Revised (SCL-90-R)...
January 18, 2018: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/29345244/in-vitro-physical-and-biological-characterization-of-biodegradable-elastic-polyurethane-containing-ferulic-acid-for-small-caliber-vascular-grafts
#6
Shiva Asadpour, Jafar Ai, Parivash Davoudi, Masoud Ghorbani, Marzieh Jalali, Hossein Ghanbari
Demand for small diameter vascular grafts is growing. Main limitations of these grafts include induced thrombotic events, lack of in-situ endothelialization, intimal hyperplasia and poor mechanical properties which impair the graft patency rate in long term applications. Most of the used antithrombotic modification methods usually conflict with formation of endothelial cell monolayer on the grafts. Here, we synthesized a novel biodegradable elastic poly (ester ether urethane urea) (PEEUU) using poly (ethylene glycol) (PEG) and poly (diethylene glycol adipate) (PDEGA) as soft segments...
January 18, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29345169/a-case-of-diffuse-large-b-cell-lymphoma-with-myc-gene-cluster-amplification-related-to-chromothripsis
#7
Minoru Kojima, Joaquim Carreras, Yara Yukie Kikuti, Masashi Miyaoka, Tomoki Kikuchi, Jun Amaki, Ai Sato, Daisuke Ogiya, Kiyoshi Ando, Naoya Nakamura
No abstract text is available yet for this article.
January 18, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29345144/pilot-randomized-controlled-trial-of-the-go-game-intervention-on-cognitive-function
#8
Ai Iizuka, Hiroyuki Suzuki, Susumu Ogawa, Kimi Estela Kobayashi-Cuya, Momoko Kobayashi, Toru Takebayashi, Yoshinori Fujiwara
This study investigated the effects of an intervention using the game "GO" on cognitive function in nursing home residents and evaluated the acquisition of GO according to each stage of dementia. Participants were randomly assigned to either the GO intervention group or a control group, and the intervention was performed once weekly for 15 weeks. Cognitive tests were conducted before and after intervention, and 17 participants were included in the final analysis. Analysis of covariance demonstrated that in the intervention group, the digit span total score significantly improved and the digit span backward score was maintained, whereas these scores decreased in the control group...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29344966/quorum-sensing-molecule-dihydroxy-2-3-pentanedione-and-its-analogs-as-regulators-of-epithelial-integrity
#9
S Elmanfi, X Ma, H O Sintim, E Könönen, S Syrjänen, U K Gursoy
BACKGROUND AND OBJECTIVE: Quorum-sensing molecules regulate the behavior of bacteria within biofilms and at the same time elicit an immune response in host tissues. Our aim was to investigate the regulatory role of dihydroxy-2,3-pentanedione (DPD), the precursor of universal autoinducer-2 (AI-2), and its analogs (ethyl-DPD, butyl-DPD and isobutyl-DPD) in the integrity of gingival epithelial cells. MATERIAL AND METHODS: Human gingival keratinocytes were incubated with four concentrations (10 μmol L-1 , 1 μmol L-1 , 100 nmol L-1 and 10 nmol L-1 ) of DPD and its analogs for 24 hours...
January 17, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29344913/cardiac-basal-autophagic-activity-and-increased-exercise-capacity
#10
Fang-Hui Li, Tao Li, Ying-Min Su, Jing-Yi Ai, Rui Duan, Timon Cheng-Yi Liu
To investigate whether high-intensity interval training (HIIT) and continuous moderate-intensity training (CMT) have different impacts on exercise performance and cardiac function and to determine the influence of these exercise protocols on modulating basal autophagy in the cardiac muscle of rats. Rats were assigned to three groups: sedentary control (SC), CMT, and HIIT. Total exercise volume and mean intensity were matched between the two protocols. After a 10-week training program, rats were evaluated for exercise performance, including exercise tolerance and grip strength...
January 17, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29344249/estradiol-suppresses-phosphorylation-of-er%C3%AE-serine-167-through-upregulation-of-pp2a-in-breast-cancer-cells
#11
Takanori Hayashi, Masahiro Hikichi, Jun Yukitake, Nobuhiro Harada, Toshiaki Utsumi
Aromatase inhibitors (AIs) are effective endocrine therapeutics for postmenopausal women with estrogen receptor (ER)α-positive breast cancer. However, the efficacy of the treatment is often limited by the onset of AI resistance, owing to the phosphorylation of ERα serine 167 (Ser167). Previous studies have indicated that hyperactivation of the phosphoinositide-3 kinase/RAC serine/threonine-protein kinase signaling pathway occurs in AI-resistant breast cancer models, which coincides with elevated levels of ERα phosphorylation at Ser167...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344197/overexpression-of-cxcr4-promotes-invasion-and-migration-of-non-small-cell-lung-cancer-via-egfr-and-mmp-9
#12
Jianhong Zuo, Meiling Wen, Sai Li, Xiu Lv, Lei Wang, Xiaohong Ai, Mingsheng Lei
The aim of the present study was to verify whether overexpression of CXC receptor 4 (CXCR4) promotes the invasion and migration of non-small cell lung cancer (NSCLC) via epidermal growth factor receptor (EGFR) and matrix metallopeptidase-9 (MMP-9), and to detect the association between CXCR4, EGFR and MMP-9. The effects of overexpression of CXCR4 on lung cancer cell functions were investigated by migration and invasion assays. Western blotting and zymograph assays were used to analyze the protein expression levels of EGFR and the production of MMP-9, respectively...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344105/optimal-duration-of-adjuvant-endocrine-therapy-how-to-apply-the-newest-data
#13
REVIEW
Kerstin Wimmer, Stephanie Strobl, Michael Bolliger, Yelena Devyatko, Belgin Korkmaz, Ruth Exner, Florian Fitzal, Michael Gnant
Background: The benefit of 5 years of adjuvant endocrine therapy for women with hormone receptor-positive (HR+) breast cancer (BC) is beyond discussion. Nevertheless, the risk of recurrence of luminal BC persists for 15 years or more after diagnosis. Consequently, approaches of extended adjuvant therapy have been investigated in large clinical trials, with the ultimate aim of further reducing the risk of recurrence in patients with HR+ BC. Methods: A review of recently published trial data is presented to provide a solid basis for discussion...
November 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29343847/neural-substrates-of-purely-endogenous-self-regulatory-control-of-attention
#14
Suk Won Han, Hyunji Shin, Dahee Jeong, Shinyoung Jung, Eunhee Bae, Joo Yeon Kim, Hyeon-Man Baek, Kyoheon Kim
Stimulus-driven orienting of attention toward a novel, salient stimulus is a highly adaptive behavior. In an opposing vein, it is also crucial to endogenously redirect attention to other stimuli of behavioral significance if the attended stimulus was evaluated to be unimportant. This stimulus-driven orienting and subsequent reorienting of attention are known to be mediated by similar neural substrates. However, this might be because reorienting was triggered by a sensory transition exogenously capturing attention, such as an abrupt onset of a new stimulus...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343814/intrinsic-apoptotic-pathway-activation-increases-response-to-anti-estrogens-in-luminal-breast-cancers
#15
Michelle M Williams, Linus Lee, Thomas Werfel, Meghan M Morrison Joly, Donna J Hicks, Bushra Rahman, David Elion, Courtney McKernan, Violeta Sanchez, Monica V Estrada, Suleiman Massarweh, Richard Elledge, Craig Duvall, Rebecca S Cook
Estrogen receptor-α positive (ERα+) breast cancer accounts for approximately 70-80% of the nearly 25,0000 new cases of breast cancer diagnosed in the US each year. Endocrine-targeted therapies (those that block ERα activity) serve as the first line of treatment in most cases. Despite the proven benefit of endocrine therapies, however, ERα+ breast tumors can develop resistance to endocrine therapy, causing disease progression or relapse, particularly in the metastatic setting. Anti-apoptotic Bcl-2 family proteins enhance breast tumor cell survival, often promoting resistance to targeted therapies, including endocrine therapies...
January 17, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29343723/pharmacological-targeting-of-bet-proteins-attenuates-radiation-induced-lung-fibrosis
#16
Jian Wang, Fangzheng Zhou, Zhenyu Li, Hong Mei, Ye Wang, Hong Ma, Liangliang Shi, Ai Huang, Tao Zhang, Zhenyu Lin, Gang Wu
Radiation-induced lung injury has restricted radiotherapy for thoracic cancer. The purpose of this study was to investigate the radioprotective effects of bromodomain and extra terminal (BET) inhibitor JQ1 in a murine model of pulmonary damage. Chest computed tomography (CT) was performed in a rat model after 20 Gy radiation of the right thorax. And histological evaluation and protein expressions of irradiated tissue were analyzed to confirm the potential anti-fibrosis effect of JQ1 and its underlying mechanisms...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343029/-microrna-targeted-to-chronic-myeloid-leukemia-bcr-abl-oncogene-screen-using-deacetylase-inhibitor
#17
Z D Ai, H Y Wu, L Chen
Objective: microRNA targeted to chronic myeloid leukemia Bcr-Abl oncogene were screened using the deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Methods: The proliferation inhibition effect of SAHA on chronic myeloid leukemia K562 cell was detected by MTS method, and the optimal concentration of SAHA reaction was determined. Western blot was used to detect the level of PARP protein, and making sure whether SAHA induced apoptosis of K562 cell. Effect of SAHA on Bcr-Abl Gene Transcription in K562 Cells was determined by Fluorescence Quantitative PCR...
January 2, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29342359/semiconducting-photothermal-nanoagonist-for-remote-controlled-specific-cancer-therapy
#18
Xu Zhen, Chen Xie, Yuyan Jiang, Xiangzhao Ai, Bengang Xing, Kanyi Pu
Nanomedicines have shown success in cancer therapy, but the pharmacological actions of most nanomedicine are often nonspecific to cancer cells because of utilization of the therapeutic agents that induce cell apoptosis from inner organelles. We herein report the development of semiconducting photothermal nanoagonists that can remotely and specifically initiate the apoptosis of cancer cells from cell membrane. The organic nanoagonists comprise semiconducting polymer nanoparticles (SPNs) and capsaicin (Cap) as the photothermally-responsive nanocarrier and the agonist for activation of transient receptor potential cation channel subfamily V member 1 (TRPV1), respectively...
January 17, 2018: Nano Letters
https://www.readbyqxmd.com/read/29342237/the-roles-of-subdivisions-of-human-insula-in-emotion-perception-and-auditory-processing
#19
Yang Zhang, Wenjing Zhou, Siyu Wang, Qin Zhou, Haixiang Wang, Bingqing Zhang, Juan Huang, Bo Hong, Xiaoqin Wang
Previous studies have shown insular activations involving sensory, motor, and affective processing. However, the functional roles of subdivisions within the human insula are still not well understood. In the present study, we used intracranial electroencephalography and electrical cortical stimulation to investigate the causal roles of subdivisions of the insula in auditory emotion perception in epilepsy patients implanted with depth electrodes in this brain region. The posterior and the anterior subdivisions of the human insula, identified based on structural and functional analyses, showed distinct response properties to auditory emotional stimuli...
January 12, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29342205/correction-cholecystectomy-can-increase-the-risk-of-colorectal-cancer-a-meta-analysis-of-10-cohort-studies
#20
Yong Zhang, Hao Liu, Li Li, Min Ai, Zheng Gong, Yong He, Yunlong Dong, Shuanglan Xu, Jun Wang, Bo Jin, Jianping Liu, Zhaowei Teng
[This corrects the article DOI: 10.1371/journal.pone.0181852.].
2018: PloS One
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