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Ablation Techniques

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https://www.readbyqxmd.com/read/28721494/a-comprehensive-characterization-of-parameters-affecting-high-frequency-irreversible-electroporation-lesions
#1
Tyler Miklovic, Eduardo L Latouche, Matthew R DeWitt, Rafael V Davalos, Michael B Sano
Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwave ablation, rely on thermal damage mechanisms which can put critical nerves or vasculature at risk. Irreversible electroporation (IRE) is a minimally invasive, non-thermal technique to destroy tumors. A series of short electric pulses create nanoscale defects in the cell membrane, eventually leading to cell death. Typical IRE protocols deliver a series of 50-100 µs monopolar pulses...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28718950/radiofrequency-ablation-for-the-management-of-thyroid-nodules-a-critical-appraisal-of-the-literature
#2
REVIEW
Roberto Cesareo, Andrea Palermo, Valerio Pasqualini, Roberto Cianni, Gianluigi Gaspa, Silvia Manfrini, Claudio Maurizio Pacella
The majority of benign thyroid nodules are asymptomatic, remain stable in size, and do not require treatment. However, a minority of patients with growing nodules may have local symptoms or cosmetic concerns, and thus demand surgical therapy. The timely use of ultrasound-guided, minimally invasive thermal therapies has changed the natural history of benign, enlarging thyroid nodules (TNs). These procedures produce persistent shrinkage of TNs and an improvement of local symptoms. Among the various procedures, percutaneous ethanol injection (PEI) represents the first-line treatment for thyroid cysts, while in solid cold nodules, laser and radiofrequency ablation (RFA) have proven to be very effective and safe techniques in producing significant volume reduction that remains stable over several years...
July 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28718844/solvent-gradient-electrospray-for-laser-ablation-electrospray-ionization-mass-spectrometry
#3
Hang Li, Akos Vertes
Most electrospray based ambient ionization techniques, e.g., laser ablation electrospray ionization (LAESI), utilize a fixed spray solution composition. Complex samples often contain compounds of different polarity that exhibit a wide range of solubilities in the electrospray solvent. Thus, the fixed spray solution composition limits the molecular coverage of these approaches. Two-barrel theta glass capillaries have been used for the rapid mixing of two solutions for manipulating fast reactions including protein folding, unfolding, and charge state distributions...
July 18, 2017: Analyst
https://www.readbyqxmd.com/read/28718606/-interventional-treatment-of-venous-insufficiency
#4
Barbara Ney, Rolf P Engelberger, Amin Dabiri, Jean-François Lüthi, Andreas Erdmann, Caroline Krieger, Sébastien Déglise, Thierry Merminod, Philippe Kern, Lucia Mazzolai
Interventional treatment of venous insufficiency has been revolutionized by endovascular techniques. Some of these techniques, and particularly thermal ablation (endovenous laser, radiofrequency) are now recommended as first-line therapy in the latest international guidelines. This is because of less post-operative pain, a shorter leave from employment and similar or lower recurrence rate. Endovenous techniques allow safer and more efficient treatment of certain particular conditions : small saphenous vein, ulcers, and recurrent varicose veins...
March 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28712275/predictive-factors-of-symptomatic-radiation-pneumonitis-in-primary-and-metastatic-lung-tumors-treated-with-stereotactic-ablative-body-radiotherapy
#5
Kangpyo Kim, Jeongshim Lee, Yeona Cho, Seung Yeun Chung, Jason Joon Bock Lee, Chang Geol Lee, Jaeho Cho
PURPOSE: Although stereotactic ablative body radiotherapy (SABR) is widely used therapeutic technique, predictive factors of radiation pneumonitis (RP) after SABR remain undefined. We aimed to investigate the predictive factors affecting RP in patients with primary or metastatic lung tumors who received SABR. MATERIALS AND METHODS: From 2012 to 2015, we reviewed 59 patients with 72 primary or metastatic lung tumors treated with SABR, and performed analyses of clinical and dosimetric variables related to symptomatic RP...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28709536/margin-analysis-has-free-tissue-transfer-improved-oncologic-outcomes-for-oral-squamous-cell-carcinoma
#6
REVIEW
Sean P Edwards
Microvascular reconstruction of ablative defects has become a mainstay of contemporary management of head and neck cancer patients. These techniques offer myriad tissue options that vary in character, volume, and components and have vastly improved the esthetic and functional outcomes achieved in this patient population. Although consensus exists regarding the reliability and functional and esthetic benefits of free tissue transfer, the same cannot be said for oncologic outcomes. The increase in resources required for the routine use of free tissue transfer has led to asking this question-Do vascularized free flaps allow for increased surgical margins and improvements in oncologic outcomes?...
August 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28709036/hydroxyapatite-and-bioactive-glass-surfaces-for-fiber-reinforced-composite-implants-via-surface-ablation-by-excimer-laser
#7
Julia Kulkova, Niko Moritz, Hannu Huhtinen, Riina Mattila, Ivan Donati, Eleonora Marsich, Sergio Paoletti, Pekka K Vallittu
In skeletal reconstructions, composites, such as bisphenol-A-glycidyldimethacrylate resin reinforced with glass fibers, are potentially useful alternatives to metallic implants. Recently, we reported a novel method to prepare bioactive surfaces for these composites. Surface etching by Excimer laser was used to expose bioactive glass granules embedded in the resin. The purpose of this study was to analyze two types of bioactive surfaces created by this technique. The surfaces contained bioactive glass and hydroxyapatite granules...
July 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28707966/targeted-molecular-ablation-of-cancer-stem-cells-for-curing-gastrointestinal-cancers
#8
Yong Seok Kim, Ho Jae Lee, Jong-Min Park, Young-Min Han, Napapan Kangwan, Ji Young Oh, Dong Yoon Lee, Ki Baik Hahm
Abundance of the ATPase-binding cassette (ABC) transporters and deranged self-renewal pathways characterize the presence of cancer stem cells (CSCs) in gastrointestinal cancers (GI cancers), which play crucial roles in tumorigenesis, chemotherapy resistance, tumor recurrence, and cancer metastasis. Therefore, in order to ensure high cure rates, chemoquiescence, CSCs should be ablated. Recent advances in either understanding CSCs or biomarker identification enable scientists to develop techniques for ablating CSCs and clinicians to provide cancer cure, especially in GI cancers characterized by inflammation-driven carcinogenesis...
July 14, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28707848/frontiers-in-non-invasive-cardiac-mapping-future-implications-for-arrhythmia-treatment
#9
Antonio Frontera, Ghassen Cheniti, Claire A Martin, Masateru Takigawa, Josselin Duchateau, Stephane Puyo, Ruairidh Martin, Nathaniel Thompson, Takeshi Kitamura, Konstantinos Vlachos, Michael Wolf, Nora Al-Jefairi, Gregoire Massouille, Thomas Pambrun, Arnaud Denis, Frederic Sacher, Nicolas Derval, Remis Dubois, Pierre Jaïs, Meleze Hocini, Michel Haissaguerre
Electrocardiographic mapping (ECM) is a non invasive technique using body surface potentials and CT geometry to reconstruct epicardial maps. ECM is emerging as an important tool not only for diagnostic mapping, but also as a guide for trans-catheter ablation of complex arrhythmias such as atrial fibrillation. It provides the clinician with an immediate global view of the substrate, allowing easier pre-procedural planning, potential improving clinical outcomes. Panoramic mapping of ventricular fibrillation (VF) is helping to develop a better understanding of its physiology, with future implications for the identification of therapeutic targets in patients with structural heart disease, as well as in idiopathic VF...
July 12, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28706840/arthroscopic-excision-of-osteoid-osteoma-of-the-talus
#10
Iftach Hetsroni, Meir Nyska, Evgeny Edelshtein, Gideon Mann, Ezequiel Palmanovich
Osteoid osteoma is a benign tumor that can cause significant pain and disability. Excision of the tumor can be accomplished with open surgery or, as advocated in recent years, with computed tomography (CT)-guided radiofrequency ablation. In this article, a unique arthroscopic approach to excise an osteoid osteoma of the talus is presented. This was possible by relying on a clear intra-articular prominent osteophyte, which was used as a landmark to indicate tumor location in accordance with preoperative CT views...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706798/arthroscopic-excision-of-osteoid-osteoma-of-the-elbow
#11
Deepak N Bhatia
Osteoid osteoma has been reported infrequently around the elbow joint, and is usually treated with radiofrequency ablation or open excision. Elbow arthroscopy is useful for excision of accessible lesions, and the accompanying elbow stiffness can be treated concurrently. This report describes an arthroscopic excision of an osteoid osteoma located in the juxta-articular distal humeral bone. An initial adhesiolysis and capsulectomy is performed to gain access to the region above the capitellar articular margin...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706589/catheter-ablation-of-atrial-fibrillation-facilitated-by-preprocedural-three-dimensional-transesophageal-echocardiography-long-term-outcome
#12
Klaus Kettering, Felix Gramley, Stephan von Bardeleben
AIM: To evaluate the long-term outcome of catheter ablation of atrial fibrillation (AF) facilitated by preprocedural three-dimensional (3-D) transesophageal echocardiography. METHODS: In 50 patients, 3D transesophageal echocardiography (3D TEE) was performed immediately prior to an ablation procedure (paroxysmal AF: 30 patients, persistent AF: 20 patients). The images were available throughout the ablation procedure. Two different ablation strategies were used. In most of the patients with paroxysmal AF, the cryoablation technique was used (Arctic Front Balloon, CryoCath Technologies/Medtronic; group A2)...
June 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28705805/validation-and-characterization-of-a-novel-method-for-selective-vagal-deafferentation-of-the-gut
#13
Charlene Diepenbroek, Danielle Quinn, Ricky Stephens, Benjamin Zollinger, Seth Anderson, Annabelle Pan, Guillaume de Lartigue
There is a lack of tools that selectively target vagal afferent neurons (VAN) innervating the gut. We use saporin (SAP), a potent neurotoxin, conjugated to the GI hormone cholecystokinin (CCK-SAP) injected into the nodose ganglia (NG) of male Wistar rats to specifically ablate GI-VAN. We report that CCK-SAP ablates a sub-population of VAN in culture. In vivo, CCK-SAP injection into the NG reduces VAN innervating the mucosal and muscular layers of the stomach and small intestine, but not the colon, while leaving vagal efferent neurons intact...
July 13, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28705258/fate-bias-during-neural-regeneration-adjusts-dynamically-without-recapitulating-developmental-fate-progression
#14
Jeremy Ng Chi Kei, Peter David Currie, Patricia Regina Jusuf
BACKGROUND: Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural retina of zebrafish, Müller glia are the main stem cell source and are capable of generating progenitors to replace lost neurons after injury. However, it remains largely unknown to what extent Müller glia and neuron differentiation mirror development. METHODS: Following neural ablation in the zebrafish retina, dividing cells were tracked using a prolonged labelling technique...
July 13, 2017: Neural Development
https://www.readbyqxmd.com/read/28704698/interventional-radiology-in-breast-cancer
#15
REVIEW
Lizbeth Moira Kenny, Franco Orsi, Andreas Adam
Molecular profiling of metastatic disease may greatly influence the systemic therapy recommended by oncologists and chosen by patients, allowing treatment to be more targeted. Comprehensive care of patients with advanced breast cancer now includes percutaneous image-guided biopsy if this has the potential to influence systemic treatment [1]. Interventional radiologists can contribute significantly to the care of patients affected by breast cancer, in diagnostic and supportive procedures and importantly also in treatment...
July 10, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28704537/non-invasive-localization-of-atrial-ectopic-beats-by-using-simulated-body-surface-p-wave-integral-maps
#16
Ana Ferrer-Albero, Eduardo J Godoy, Miguel Lozano, Laura Martínez-Mateu, Felipe Atienza, Javier Saiz, Rafael Sebastian
Non-invasive localization of continuous atrial ectopic beats remains a cornerstone for the treatment of atrial arrhythmias. The lack of accurate tools to guide electrophysiologists leads to an increase in the recurrence rate of ablation procedures. Existing approaches are based on the analysis of the P-waves main characteristics and the forward body surface potential maps (BSPMs) or on the inverse estimation of the electric activity of the heart from those BSPMs. These methods have not provided an efficient and systematic tool to localize ectopic triggers...
2017: PloS One
https://www.readbyqxmd.com/read/28704384/quantitative-thyroglobulin-response-to-radioactive-iodine-treatment-in-predicting-radioactive-iodine-refractory-thyroid-cancer-with-pulmonary-metastasis
#17
Chen Wang, Xin Zhang, Hui Li, Xin Li, Yansong Lin
OBJECTIVE: Current diagnosis of radioactive iodine (RAI)-refractory (RAIR) differentiated thyroid cancer (DTC) is based on the imaging technique, which is of a high cost. Serum thyroglobulin (Tg) is a sensitive and easily obtained biomarker. Hence, we aimed to assess the predicting value of quantitative response of Tg in earlier identifying the RAIR-DTC with pulmonary metastasis. PATIENTS AND METHODS: Pulmonary metastatic DTC patients who underwent total or near-total thyroidectomy and at least two times of RAI therapy were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28700983/intratumoral-coagulation-by-radiofrequency-ablation-facilitated-the-laparoscopic-resection-of-giant-hepatic-hemangioma-a-surgical-technique-report-of-two-cases
#18
Shaohong Wang, Jun Gao, Mengmeng Yang, Shan Ke, Xuemei Ding, Jian Kong, Li Xu, Wenbing Sun
BACKGROUND: Traditionally, open hepatic resection is the first choice of treatment for symptomatic enlarging hepatic hemangiomas, which requires a large abdominal incision and is associated with substantial recovery time and morbidity. Minimally invasive laparoscopic resection has been used recently in liver surgery for treating selected hepatic hemangiomas. However, laparoscopic liver surgery poses the significant technical challenges and high rate of conversion. Radiofrequency (RF) ablation has been proved feasible in the treatment of hepatic hemangiomas with a size range of 5...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699509/combination-of-multifunctional-nanoparticles-and-interventional-techniques-makes-each-other-going-further-in-the-field-of-cancer-treatment
#19
Haibo Shao, Tengchuang Ma, Duo Hong, Wenhan Xu, Shuai Li, Ronald S Arellano, Ke Xu
Nano-oncology and interventional oncology are both rapidly emerging fields in loco-regional cancer therapies. Synergistic combination of both fields offers drastic improvement in performance and efficacy of cancer killings. Interventional techniques such selective arterial catheterization, irreversible electroporation (IRE) and radiofrequency ablation (RFA) had dramatically enhance the cancer targetability and anticancer efficacy of nanoparticles (NPs). Furthermore, there is synergistic effect by using different interventional techniques together on NPs assisted cancer treatment...
July 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28699085/laser-interstitial-thermal-therapy-for-epilepsy
#20
REVIEW
Eric Prince, Shahin Hakimian, Andrew L Ko, Jeffrey G Ojemann, Michelle S Kim, John W Miller
MRI-guided laser interstitial thermal therapy (MgLiTT) uses a narrow diameter cannula to stereotactically target and heat deeper cerebral structures. This technique produces a precise lesion in the brain with great reliability because the localized tissue temperature change is monitored in real time. Because MgLiTT minimizes injury to surrounding brain, it appears to have a lower risk of affecting normal neurological function, and because it is done through a burr hole, there is less operative risk, less discomfort, and shorter hospitalizations...
September 2017: Current Neurology and Neuroscience Reports
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