keyword
https://read.qxmd.com/read/38535973/-pseudomonas-stutzeri-bloodstream-infection-is-a-prevailing-community-onset-disease-with-important-mortality-rates-results-from-a-retrospective-observational-study-in-australia
#1
JOURNAL ARTICLE
Juan P Horcajada, Felicity Edwards, Silvia Fonio, Milagro Montero, Patrick Harris, David L Paterson, Kevin B Laupland
BACKGROUND: The recognition of Pseudomonas stutzer i as a cause of infections in humans has been increasing. However, only case reports and small series of P. stutzeri bloodstream infections have been published. Epidemiological data on these infections are extremely scarce. Our objective was to describe the incidence, epidemiology, antimicrobial resistance rates, and outcomes of P. stutzeri bloodstream infections in a large population-based cohort in Australia. METHODS: Retrospective, laboratory-based surveillance study conducted in Queensland, Australia (population ≈ 5 million) during 2000-2019...
March 27, 2024: Infectious Diseases
https://read.qxmd.com/read/38535032/impact-of-ai-based-post-processing-on-image-quality-of-non-contrast-computed-tomography-of-the-chest-and-abdomen
#2
JOURNAL ARTICLE
Marcel A Drews, Aydin Demircioğlu, Julia Neuhoff, Johannes Haubold, Sebastian Zensen, Marcel K Opitz, Michael Forsting, Kai Nassenstein, Denise Bos
Non-contrast computed tomography (CT) is commonly used for the evaluation of various pathologies including pulmonary infections or urolithiasis but, especially in low-dose protocols, image quality is reduced. To improve this, deep learning-based post-processing approaches are being developed. Therefore, we aimed to compare the objective and subjective image quality of different reconstruction techniques and a deep learning-based software on non-contrast chest and low-dose abdominal CTs. In this retrospective study, non-contrast chest CTs of patients suspected of COVID-19 pneumonia and low-dose abdominal CTs suspected of urolithiasis were analysed...
March 13, 2024: Diagnostics
https://read.qxmd.com/read/38534705/scientific-rationale-and-clinical-basis-for-clindamycin-use-in-the-treatment-of-dermatologic-disease
#3
REVIEW
Maria K Armillei, Ivan B Lomakin, James Q Del Rosso, Ayman Grada, Christopher G Bunick
Clindamycin is a highly effective antibiotic of the lincosamide class. It has been widely used for decades to treat a range of skin and soft tissue infections in dermatology and medicine. Clindamycin is commonly prescribed for acne vulgaris, with current practice standards utilizing fixed-combination topicals containing clindamycin that prevent Cutibacterium acnes growth and reduce inflammation associated with acne lesion formation. Certain clinical presentations of folliculitis, rosacea, staphylococcal infections, and hidradenitis suppurativa are also responsive to clindamycin, demonstrating its suitability and versatility as a treatment option...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38533914/recycled-bone-grafts-treated-with-extracorporeal-irradiation-or-liquid-nitrogen-freezing-after-malignant-tumor-resection
#4
JOURNAL ARTICLE
Yuta Takeuchi, Akio Sakamoto, Takashi Noguchi, Junya Toguchida, Shuichi Matsuda
INTRODUCTION: Recycled bone autografts prepared using extracorporeal irradiation (ECIR) or liquid nitrogen freezing (LNF) methods have been used for the reconstruction of skeletal elements after wide resection of sarcomas involving bone tissues. Few reports include long-term follow-up data for histological analyses of recycled autografts, particularly in the case of ECIR autografts. MATERIALS: A total of 34 malignant bone and soft tissue tumors were resected and reconstructed using 11 ECIR- and 23 LNF-recycled autografts; the mean postoperative follow-ups were 14 and 8 years, respectively...
March 27, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38533511/bones-on-fire-illuminating-osteomyelitis-through-the-radiant-lens-of-18-f-fdg-pet-ct
#5
REVIEW
Mei Yang, Quanhui Tan, Zhenghao Tang
Osteomyelitis is an inflammatory process that is caused by an infecting microorganism and leads to progressive bone destruction and loss. Osteomyelitis can occur at any age and can involve any bone. The infection can be limited to a single portion of the bone or can involve several regions, such as marrow, cortex, periosteum, and the surrounding soft tissue. Early and accurate diagnosis plays a crucial role in reducing unnecessary treatment measures, improving the patient's prognosis, and minimizing time and financial costs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38530145/free-flap-reconstruction-of-elbow-soft-tissue-defects-lessons-learned-from-15%C3%A2-years-of-experience
#6
J Reed McGraw, Reena S Sulkar, Corey M Bascone, Sammy Othman, Jaclyn T Mauch, Hani I Naga, L Scott Levin, Stephen J Kovach
BACKGROUND: The elbow is a complex joint that is vital for proper function of the upper extremity. Reconstruction of soft tissue defects over the joint space remains challenging, and outcomes following free tissue transfer remain underreported in the literature. The purpose of this analysis was to evaluate the rate of limb salvage, joint function, and clinical complications following microvascular free flap coverage of the elbow. METHODS: This retrospective case series utilized surgical logs of the senior authors (Stephen J Kovach and L Scott Levin) to identify patients who underwent microvascular free flap elbow reconstruction between January 2007 and December 2021...
May 2024: Microsurgery
https://read.qxmd.com/read/38529577/comparative-analysis-of-ct-findings-and-clinical-outcomes-in-adult-patients-with-disseminated-and-localized-pulmonary-nocardiosis
#7
JOURNAL ARTICLE
Han Na Lee, Kyung-Hyun Do, Eun Young Kim, Jooae Choe, Heungsup Sung, Sang-Ho Choi, Hwa Jung Kim
BACKGROUND: Pulmonary nocardiosis is a rare opportunistic infection with occasional systemic dissemination. This study aimed to investigate the computed tomography (CT) findings and prognosis of pulmonary nocardiosis associated with dissemination. METHODS: We conducted a retrospective analysis of patients diagnosed with pulmonary nocardiosis between March 2001 and September 2023. We reviewed the chest CT findings and categorized them based on the dominant CT findings as consolidation, nodules and/or masses, consolidation with multiple nodules, and nodular bronchiectasis...
March 25, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38529283/vaccination-with-staphylococcal-protein-a-protects-mice-against-systemic-complications-of-skin-infection-recurrences
#8
JOURNAL ARTICLE
Andrea Paola Mandelli, Greta Magri, Marco Tortoli, Stefania Torricelli, Donatello Laera, Fabio Bagnoli, Oretta Finco, Giuliano Bensi, Michela Brazzoli, Emiliano Chiarot
Skin and soft tissue infections (SSTIs) are the most common diseases caused by Staphylococcus aureus ( S. aureus ), which can progress to threatening conditions due to recurrences and systemic complications. Staphylococcal protein A (SpA) is an immunomodulator antigen of S. aureus , which allows bacterial evasion from the immune system by interfering with different types of immune responses to pathogen antigens. Immunization with SpA could potentially unmask the pathogen to the immune system, leading to the production of antibodies that can protect from a second encounter with S...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38527992/the-influence-of-sepsis-on-erythrocytes-morphology-case-report-and-literature-review
#9
JOURNAL ARTICLE
Cristian Mircea Nicolescu, Silviu Daniel Moldovan
This paper highlights a clinical case of sepsis caused by soft tissue infection. Peripheral blood smear, plasma value of inflammatory biomarkers and the white blood cells count were performed. Significant morphological changes were revealed through peripheral blood smear test two days after patient admission. Patient developed septic shock after the third day in intensive care unit (ICU). Laboratory results showed major morphological changes (erythrocytes deformity, abnormal neutrophils); these were correlated with elevated plasma value of interleukin-6 and procalcitonin...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38525477/mechanisms-of-antibiotic-resistance-and-developments-in-therapeutic-strategies-to-combat-klebsiella-pneumoniae-infection
#10
REVIEW
Yanping Li, Suresh Kumar, Lihu Zhang
Infections with drug-resistant bacteria have become one of the greatest public health challenges, and K. pneumoniae is among the top six drug-resistant bacteria. K. pneumoniae often causes nosocomial infections, leading to illnesses such as pneumonia, liver abscesses, soft tissue infections, urinary tract infections, bacteremia, and in some cases death. As the pathogen continues to evolve and its multidrug resistance increases, K. pneumoniae poses a direct threat to humans. Drug resistance in K. pneumoniae may occur due to the formation of biofilms, efflux pumps, and the production of β-lactamases...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38524076/facial-cellulitis-and-skin-abscess-a-case-of-a-simple-bone-cyst-in-the-mandibular-bone
#11
Katsunori Tanaka, Yasuhiko Tsutsumi, Takumi Nakatani, Midori Tagaya
Cellulitis, abscess, or both are among the most common skin and soft tissue infections. Typically, cellulitis arises due to bacterial penetration through breaches in the skin's protective barrier. However, in cases of facial cellulitis, it is necessary to consider not only the breakdown of the skin barrier but also to differentiate odontogenic cellulitis. A prompt and accurate diagnosis of facial infections stemming from dental issues, coupled with the administration of antibiotics and dental interventions, played a crucial role in resolving this condition...
February 2024: Curēus
https://read.qxmd.com/read/38524043/excision-of-invasive-squamous-cell-carcinoma-complicated-by-osteomyelitis-and-tobacco-use-a-case-report
#12
Harriet Kaye Austin, Gloria M Gamboa, Carlene Waters-Hollingsworth
Squamous cell carcinoma (SCC) is a common type of skin cancer that can be treated through surgical excision using Mohs micrographic surgery (MMS) which results in minimal scarring and low complications. Soft tissue defects as a result of MMS that are too large to be primarily closed can be repaired with secondary intention healing through the use of biologic prosthetics that promote dermal regeneration and tissue remodeling with high success rates. Other non-surgical treatment options include chemotherapy (topical or systemic), radiation, or immunotherapy for advanced skin cancers...
February 2024: Curēus
https://read.qxmd.com/read/38524028/a-rare-case-of-fungal-osteomyelitis-of-the-distal-tibia-in-a-pediatric-patient
#13
Syed Faisal Afaque, Udit Agrawal, Dilip K Shankhwar, Suresh Chand, Vikas Verma
Staphylococcus aureus infection is the most common cause of osteomyelitis. Over 100,000 fungal species have been described; only 150 are pathogenic to humans. These opportunistic infections frequently enter the body due to a decrease in host defense or through an invasive gateway, such as a dental extraction or skin discontinuity due to trauma. Symptoms and radiological examination often mimic those of other etiologies, which can lead to substantial delays in treatment. Our case is a 13-year-old healthy boy with no history of immune incompetency who presented to us with complaints of pain and swelling over his left ankle and leg with an on-and-off history of fever for 15 days...
February 2024: Curēus
https://read.qxmd.com/read/38520504/does-local-fat-thickness-correlate-with-post-operative-infection-in-open-reduction-and-internal-fixation-of-acetabulum-fractures
#14
JOURNAL ARTICLE
Jack W Weick, Reese A Svetgoff, Mitchel R Obey, Jacob J Siahaan, Ryan P Bailey, Daniel J Walsh, Jonathan G Eastman, Milton L Chip Routt, Stephen J Warner
PURPOSE: Obesity is an epidemic which increases risk of many surgical procedures. Previous studies in spine and hip arthroplasty have shown that fat thickness measured on preoperative imaging may be as or more reliable in assessment of risk of post-operative infection and/or wound complications than body mass index (BMI). We hypothesized that, similarly, increased local fat thickness at the surgical site is a predictor of wound complication in acetabulum fracture surgery. METHODS: Patients who underwent open reduction and internal fixation (ORIF) of an acetabulum fracture through a Kocher-Langenbeck (K-L) approach at a single institution from 2013 to 2020 were identified...
March 23, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38518580/a-cross-sectional-analysis-of-pediatric-necrotizing-soft-tissue-infection-cases-and-racial-disparities-from-the-2016-to-2020%C3%A2-national-inpatient-sample
#15
JOURNAL ARTICLE
Safraz A Hamid, Elena Graetz, Eric Schneider, Karen E Gibbs
INTRODUCTION: The incidence, treatment, and outcomes of necrotizing soft tissue infections (NSTIs) and associated racial disparities have been described in adults, but research in the pediatric population is limited. The purpose of this study is to provide a nationally representative characterization of pediatric NSTI and determine the presence of any racial disparities. METHODS: The National Inpatient Sample was analyzed from 2016 through 2020. Patients aged less than 20 y with a diagnosis of necrotizing fasciitis, Fournier's gangrene, or gas gangrene (based on International Classification of Diseases, Tenth Revision, Clinical Modification codes) were included for analysis...
March 21, 2024: Journal of Surgical Research
https://read.qxmd.com/read/38518234/features-of-apoptotic-and-proliferative-processes-in-experimental-infected-radiation-induced-skin-ulcer-under-conditions-of-photodynamic-therapy-and-the-use-of-platelet-rich-plasma
#16
JOURNAL ARTICLE
Olena S Pushkar, Mykhailo S Myroshnychenko, Oleh M Koliada
OBJECTIVE: . Aim: The purpose of the study was to identify the features of apoptotic and proliferative processes in experimental Staphylococcus aureus-infected radiation skin ulcer under conditions of photodynamic therapy and the use of platelet-rich plasma. PATIENTS AND METHODS: Materials and Methods: An experimental study was conducted on 95 six-month-old male rats of the WAG population, which were divided into three groups. Group 1 included 25 animals that were simulated a radiation ulcer of the skin in the thigh area with subsequent application to its surface on the 7th day after irradiation with 0...
2024: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38517016/implant-retention-in-a-rabbit-model-of-fracture-related-infection
#17
JOURNAL ARTICLE
Jan Puetzler, Alejandro Vallejo Diaz, Georg Gosheger, Martin Schulze, Daniel Arens, Stephan Zeiter, Claudia Siverino, Robert G Richards, Thomas F Moriarty
AIMS: Fracture-related infection (FRI) is commonly classified based on the time of onset of symptoms. Early infections (< two weeks) are treated with debridement, antibiotics, and implant retention (DAIR). For late infections (> ten weeks), guidelines recommend implant removal due to tolerant biofilms. For delayed infections (two to ten weeks), recommendations are unclear. In this study we compared infection clearance and bone healing in early and delayed FRI treated with DAIR in a rabbit model...
March 22, 2024: Bone & Joint Research
https://read.qxmd.com/read/38516144/the-clinical-characteristics-and-risk-factors-for-necrotizing-soft-tissue-infection-in-children
#18
JOURNAL ARTICLE
Jing Liu, Jigang Chen, Yanni Wang, Hongyan Qi, Jing Yu
IMPORTANCE: Necrotizing soft tissue infection (NSTI) is a serious infectious disease. However, the early clinical manifestations and indicators of NSTI in children are still unclear. OBJECTIVE: The purpose of this study was to analyze the clinical characteristics and risk factors of NSTI in pediatric patients. METHODS: A total of 127 children with skin and soft tissue infection (SSTI) were treated at our hospital and divided into two groups: the NSTI group and the non-NSTI group, based on their discharge diagnosis from January 2011 to December 2022...
March 2024: Pediatric Investigation
https://read.qxmd.com/read/38515773/dot-in-circle-sign-in-cervical-actinomycotic-mycetoma-an-extremely-rare-case-report
#19
Michael T Abera, Kebron A Dumessa, Taye J Robele, Tesfaye G Tefera, Abebe M Woldeyohannes
Actinomycosis is an unusual, chronic granulomatous infection caused by Actinomycetes spp. The organism also causes mycetoma, a neglected tropical disease in endemic regions. We present a very uncommon case of extensive actinomycosis of the soft tissues in the neck with perivertebral extension that showed the dot-in-circle sign on magnetic resonance imaging. A 29-year-old male patient presented with progressively enlarging hard posterior neck swelling of 4 years duration. Subsequently, magnetic resonance imaging showed the dot-in-circle sign in an avidly enhancing infiltrative lesion with extensive involvement of the neck and perivertebral soft tissue...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38513712/do-platelet-rich-concentrates-improve-the-adverse-sequelae-of-impacted-mandibular-third-molar-removal
#20
JOURNAL ARTICLE
Amir Yari, Paniz Fasih, Nader Ghotbi, Ashkan Badkoobeh, Ali Goodarzi, Mohammad Hosseini Hooshiar
BACKGROUND: Several measures have been implemented to minimize the side effects of impacted third molar (M3) removal including the use of platelet-rich fibrin (PRF). PURPOSE: This study compared the effects of three modifications of PRF (leukocyte-PRF [L-PRF], advanced-PRF [A-PRF], and advanced-PRF plus [A-PRF +]) on the side effects of impacted M3 removal. STUDY DESIGN, SETTING, AND SAMPLE: This double-blinded randomized controlled trial was conducted at the Oral Surgery Department of Kashan University between September 2022 and May 2023 on patients undergoing mandibular impacted M3 removal...
March 5, 2024: Journal of Oral and Maxillofacial Surgery
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