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https://www.readbyqxmd.com/read/29925096/inhibitors-in-hemophilia-b
#1
Cristina Santoro, Gabriele Quintavalle, Giancarlo Castaman, Erminia Baldacci, Antonietta Ferretti, Federica Riccardi, Annarita Tagliaferri
Hemophilia B (HB) is an X-linked bleeding disorder caused by deficiency of factor IX (FIX). Patients with the severe form (FIX <1%) account approximately for 30 to 45% of persons with HB and usually suffer from recurrent joint, soft-tissue, and muscle bleeds. The availability of safe plasma-derived and recombinant products has virtually abolished the risk of viral infections and the adoption of prophylactic regimens has attenuated the impact of hemophilic arthropathy. Therefore, the development of an inhibitor against FIX is currently the most serious complication that can still occur in the new generations of HB patients...
June 20, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29924414/reduction-in-pseudomonas-aeruginosa-and-staphylococcus-aureus-biofilms-from-implant-materials-in-a-diffusion-dominated-environment
#2
James P Moley, Mary S McGrath, Jeffrey F Granger, Paul Stoodley, Devendra H Dusane
Antibiotic-loaded calcium sulfate beads (CS-B) are used to treat biofilm-related periprosthetic joint infections (PJI). A previous study has shown that such beads are effective in reducing lawns biofilms grown on agar plates; however, the ability of CS-B to eradicate biofilms grown on solid orthopaedic material surfaces has not been investigated. We grew biofilms of bioluminescent strains of Pseudomonas aeruginosa Xen41 and a USA300 MRSA Staphylococcus aureus SAP231 on ultra-high molecular weight polyethylene (PE), hydroxyapatite (HA), and 316L stainless steel (SS) coupons for three days under static growth conditions, with daily nutrient exchange...
June 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29924201/bilateral-periorbital-necrotizing-fasciitis-case-report
#3
Fabio Henrique Luiz Leonardo, Mariana Anabuki, Allan Christian Pieroni Gonçalves
Necrotizing fasciitis is a severe infection of the subcutaneous tissue characterized by necrosis of the superficial fascia and overlying skin and is usually associated with previous trauma and comorbidities. Periorbital necrotizing fasciitis is rare and commonly causes visual loss and soft tissue defects. A better prognosis relies critically on early diagnosis, prompt medical treatment, and timely surgical intervention. We describe a rare case of periorbital necrotizing fasciitis in the absence of an inciting event...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29924008/pacman-flap-for-oncologic-reconstruction-of-soft-tissue-defects-after-tumor-resection-a-retrospective-case-series
#4
Guangxue Li, Lan Mu, Ye Bi, Kai Yang, Yan Liu, Zhe Peng, Yi Zhu, Huiran Zang, Saisai Cao, Peiyang Zhang, Youlei Qian
INTRODUCTION: The Pacman flap is a novel modality for repairing round soft-tissue defects after tumor resection. This modality provides a robust blood supply without microsurgical tissue rearrangement. This article reviews the authors' experience with Pacman flap for reconstruction of round soft-tissue defects. The safety and effectiveness of the Pacman flap are investigated. METHODS: Here, we describe a method for oncologic reconstruction of round soft-tissue defects with a Pacman flap after tumor resection...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922571/careful-interpretation-of-the-wound-status-is-needed-with-use-of-antibiotic-impregnated-biodegradable-synthetic-pure-calcium-sulfate-beads-series-of-39-cases
#5
Aditya Menon, Rajeev Soman, Camilla Rodrigues, Sanjay Phadke, Vikas M Agashe
Introduction: The use of antibiotic impregnated biodegradable synthetic high purity calcium sulfate (SHPCS) beads is frequently reported as they offer increased concentration of antibiotics locally, without need for removal. However some wound discharge following their use has been noted. The purpose of this study was to determine any correlation between wound discharge and infection remission. Methodology: Retrospective study of 39 cases of Osteoarticular infections from April 2013 to November 2016 in whom SHPCS beads were used...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29921683/validation-of-discharge-diagnosis-codes-to-identify-serious-infections-among-middle-age-and-older-adults
#6
Andrew D Wiese, Marie R Griffin, C Michael Stein, William Schaffner, Robert A Greevy, Edward F Mitchel, Carlos G Grijalva
OBJECTIVES: Hospitalisations for serious infections are common among middle age and older adults and frequently used as study outcomes. Yet, few studies have evaluated the performance of diagnosis codes to identify serious infections in this population. We sought to determine the positive predictive value (PPV) of diagnosis codes for identifying hospitalisations due to serious infections among middle age and older adults. SETTING AND PARTICIPANTS: We identified hospitalisations for possible infection among adults >=50 years enrolled in the Tennessee Medicaid healthcare programme (2008-2012) using International Classifications of Diseases, Ninth Revision diagnosis codes for pneumonia, meningitis/encephalitis, bacteraemia/sepsis, cellulitis/soft-tissue infections, endocarditis, pyelonephritis and septic arthritis/osteomyelitis...
June 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29921366/pancreatitis-and-systemic-coronavirus-infection-in-a-ferret-mustela-putorius-furo
#7
Sarah E Wills, Hugues H Beaufrère, Brigitte A Brisson, Russell S Fraser, Dale A Smith
A 1-y-old spayed female ferret (Mustela putorius furo) was referred for additional diagnostic evaluation after physical examination by the referring veterinarian revealed a cranial abdominal mass. The ferret had a 2-wk history of inappetence, weight loss, and lethargy. On presentation, the ferret was thin, and an approximately 3-cm mass was palpable in the cranial abdomen. No other abnormalities were noted. Abdominal ultrasonography confirmed the presence of a soft-tissue structure, with a moderate blood supply and mesenteric lymphadenopathy...
June 1, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29921240/modelling-invasive-group-a-streptococcal-disease-using-bioluminescence
#8
L E Lamb, X Zhi, F Alam, M Pyzio, C L Scudamore, S Wiles, S Sriskandan
BACKGROUND: The development of vaccines and evaluation of novel treatment strategies for invasive group A streptococcal (iGAS) disease requires suitable models of human infection that can be monitored longitudinally and are preferably non-invasive. Bio-photonic imaging provides an opportunity to reduce use of animals in infection modelling and refine the information that can be obtained, however the range of bioluminescent GAS strains available is limited. In this study we set out to develop bioluminescent iGAS strains for use in in vivo pneumonia and soft tissue disease models...
June 19, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29916973/adjunctive-use-of-the-dermocartilaginous-ligament-for-dorsal-irregularities-in-primary-rhinoplasty
#9
Orhan Ozturan, Alper Yenigun, Selahattin Tugrul, Fadlullah Aksoy
Nasal dorsal irregularity is a common postrhinoplasty complication in spite of meticulous smoothing. Utilization of the dermocartilaginous ligament in 2 different fashions for different purposes was described before. A novel utilization of the dermocartilaginous ligament as a flattened and pedicled flap from the cephalic attachment for nasal dorsal irregularities was presented in this article. This surgical technique was applied in 11 cases. Eight of them had thin skin, 2 had skin with medium thickness, and 1 had thick skin...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29915657/daptomycin-associated-eosinophilic-pneumonia-case-report-and-differential-diagnoses
#10
Sijan Basnet, Niranjan Tachamo, Rashmi Dhital, Biswaraj Tharu
Daptomycin is a bactericidal antibiotic approved for treatment of gram-positive skin and soft tissue infections. We present a case of an 89-year-old man who presented with fever, shortness of breath and nonproductive cough on week 4 of starting daptomycin for infective endocarditis. Computerized tomography scan showed bilateral interstitial infiltrates predominantly affecting the lower lobes. He also had peripheral eosinophilia of 6%. He was diagnosed with eosinophilic pneumonia secondary to daptomycin use...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29914924/intravenous-cefazolin-plus-oral-probenecid-versus-oral-cephalexin-for-the-treatment-of-skin-and-soft-tissue-infections-a-double-blind-non-inferiority-randomised-controlled-trial
#11
Dawn Dalen, Amy Fry, Samuel G Campbell, Jeffrey Eppler, Peter J Zed
OBJECTIVE: The purpose of our study was to determine if cephalexin 500 mg orally four times daily was non-inferior to cefazolin 2 g intravenously daily plus probenecid 1 g orally daily in the management of patients with uncomplicated mild-moderate skin and soft tissue infection (SSTI) presenting to the ED. METHODS: This was a prospective, multicentre, double dummy-blind, randomised controlled non-inferiority trial conducted at two tertiary care teaching hospitals in Canada...
June 18, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29912846/dissemination-of-the-methicillin-resistance-staphylococcus-aureus-pediatric-clone-st5-t002-iv-pvl-as-a-major-cause-of-community-associated-staphylococcal-infections-in-bedouin-children-southern-israel
#12
Assaf Rokney, Moti Baum, Shalom Ben-Shimol, Orli Sagi, Einav Anuka, Vered Agmon, David Greenberg, Lea Valinsky, Dana Danino
INTRODUCTION: Pediatric community associated methicillin resistant Staphylococcus aureus (CA-MRSA) infections are emerging worldwide. High CA-MRSA carriage rates were previously described in healthy Bedouin children. We assessed demographic, clinical and molecular characteristics of pediatric MRSA infections in southern Israel. METHODS: The Soroka University Medical Center laboratory serves the entire population of southern Israel, divided into two ethnic groups, Bedouins and Jews...
June 15, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29912305/decreasing-incidence-of-skin-and-soft-tissue-infections-at-86-u-s-emergency-departments-2009-2014
#13
Ethan Morgan, Sam Hohmann, Jessica Ridgeway, Robert Daum, Michael Z David
Introduction: The incidence of skin and soft tissue infections (SSTIs), for which HIV is a significant risk factor, in United States emergency departments (EDs) increased dramatically after 2000 with the emergence of CA-MRSA. Few studies have examined SSTI incidence among U.S. HIV-infected and non-HIV-infected patients after 2010. Methods: Data were obtained for patient encounters at all academic medical center EDs affiliated with the Vizient clinical data warehouse who had an SSTI-associated ICD-9 code between January 1, 2009 and December 31, 2014...
June 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29911058/prevalence-of-soft-tissue-lesions-among-women-in-sex-work-in-the-red-light-area-of-pune-india-a-cross-sectional-survey
#14
Shrikanth Muralidharan, Arunkumar Acharya, Tejaswi Sevekari, Sanaa Wadwan, Noopur Rajiv Joglekar, Shanthi Margabandhu
Aim and Objective: The women in sex work have no felt need for oral health and much of the stress has always been on sexually transmitted infections (STIs). There is a need for a baseline data for the oral lesions of these women to further assist in the policy formulations and training of personnel for the identification of the oral conditions which need treatment. The aim of the study was to evaluate the presence of oral lesions among female sex workers in the red light area of Pune, India...
May 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29907912/temporary-epiphysiodesis-using-the-flextack%C3%A2-implant-tension-band-featuring-a-modified-explantation-technique
#15
REVIEW
S Koob, M Kehrer, M Hettchen, T Jansen, J Schmolders, R Placzek
OBJECTIVE: Presenting the implantation of the PediatrOS™ FlexTack™ (Merete, Berlin, Germany) for growth guidance and a modified explantation procedure to facilitate explantation and prevent bone and soft tissue damage. INDICATIONS: Implantation: Genua vara and valga, coxa vara, varus and valgus deviation of the ankle joint, the elbow joint and the wrist Modified Explantation: Removal of the implant after successful limb correction or dislocation of the implant...
June 15, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29907621/heroin-use-is-associated-with-aa-type-kidney-amyloidosis-in-the-pacific-northwest
#16
Arjun Sharma, Priyanka Govindan, Mirna Toukatly, Jack Healy, Connor Henry, Steve Senter, Behzad Najafian, Bryan Kestenbaum
BACKGROUND AND OBJECTIVES: AA-type kidney amyloidosis is classically associated with chronic autoimmune or inflammatory disorders. However, some urban centers have reported a high prevalence of injection drug use among patients with kidney AA amyloidosis. Previous reports lack control groups to quantify associations and most predate the opioid epidemic in the United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a case-control study of 38 patients with biopsy-confirmed kidney AA amyloidosis and 72 matched control individuals without this condition from two large hospital systems in Seattle, Washington...
June 15, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29905611/perioperative-glucocorticoid-treatment-of-soft-tissue-reconstruction-in-patients-on-long-term-steroid-therapy-the-experience-of-6-cases-using-reversed-posterior-interosseous-flap-for-hand-neoplasm-surgery
#17
Yong Zhang, Lu Lu, Nanhang Lu, Yanwen Yang, Jianying Gu, Fazhi Qi
INTRODUCTION: Long-term steroid therapy is associated with increased postoperative morbidity. Whether to use a stress dose of glucocorticoids (GCs) in surgical patients remains controversial. In the present study, we reported our experience in perioperative GC treatment of 6 patients on long-term steroid therapy for autoimmune diseases undergoing hand reconstruction using reversed interosseous flap. METHODS: The reversed interosseous flap reconstructions were performed after local extended resection of hand neoplasms...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29904969/mucormycotic-parotitis-and-otitis-causing-facial-nerve-palsy-in-a-diabetic-patient
#18
Debasis Gochhait, Arun Alexender, Priyadarshini Dehuri, Vidhyalakshmi Rangarajan, Sajini Elizabeth Jacob, Neelaiah Siddaraju
Isolated invasive Mucormycosis of the parotid gland is rarely reported in the literature (1). Mucormycosis most commonly manifests as rhino-oculocerebral and pulmonary infections in the patients with altered immunity (uncontrolled Diabetes mellitus, recipients of immunosupressive therapy and underlying hematological malignancies) (2). Rarely, it causes infection in the immunocompetent individuals (3) with the involvement of unusual sites like gastrointestinal tract, ear, soft tissue and skin (4, 5). This article is protected by copyright...
June 15, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29903564/nuclear-medicine-imaging-in-the-dentomaxillofacial-region
#19
REVIEW
Heidi R Wassef, Patrick M Colletti
Nuclear medicine studies evaluate physiology on a molecular level providing earlier detection of lesions before morphologic change is evident. 99m Tc-MDP and 18 F-fluoride bone scans detect osteomyelitis earlier than radiographs and computed tomography (CT); aid in diagnosis of temporomandibular joint disorder; and evaluate activity of condylar hyperplasia, extent of Paget disease, and viability of bone grafts. 18 F-FDG PET/CT distinguish between soft tissue and bone infections and diagnose osteomyelitis complicated by fracture or surgery...
July 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29900086/mass-compression-from-recurrent-lymphoma-mimicking-lower-extremity-cellulitis
#20
David G Li, Katherine M Krajewski, Arash Mostaghimi
Cellulitis is a common skin and soft tissue infection with substantial misdiagnosis rates due to its nonspecific clinical characteristics. In this report, we present a patient with recurrent metastatic diffuse large B-cell lymphoma (DLBCL) masquerading as a unilateral lower extremity cellulitis. A 62-year-old man with a history of DLBCL, in remission for two years, presented with a two-week history of swelling and erythema of the right thigh and leg. Despite treatment with clindamycin and cephalexin, the redness and swelling continued to progress...
April 12, 2018: Curēus
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