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https://www.readbyqxmd.com/read/27922116/risk-assessment-of-recent-egyptian-h5n1-influenza-viruses
#1
A-S Arafa, S Yamada, M Imai, T Watanabe, S Yamayoshi, K Iwatsuki-Horimoto, M Kiso, Y Sakai-Tagawa, M Ito, T Imamura, N Nakajima, K Takahashi, D Zhao, K Oishi, A Yasuhara, C A Macken, G Zhong, A P Hanson, S Fan, J Ping, M Hatta, T J S Lopes, Y Suzuki, M El-Husseiny, A Selim, N Hagag, M Soliman, G Neumann, H Hasegawa, Y Kawaoka
Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are enzootic in poultry populations in different parts of the world, and have caused numerous human infections in recent years, particularly in Egypt. However, no sustained human-to-human transmission of these viruses has yet been reported. We tested nine naturally occurring Egyptian H5N1 viruses (isolated in 2014-2015) in ferrets and found that three of them transmitted via respiratory droplets, causing a fatal infection in one of the exposed animals...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920760/prevalence-of-the-antibiotic-resistance-genes-in-coagulase-positive-and-negative-staphylococcus-in-chicken-meat-retailed-to-consumers
#2
Kamelia Osman, Jihan Badr, Khalid S Al-Maary, Ihab M I Moussa, Ashgan M Hessain, Zeinab M S Amin Girah, Usama H Abo-Shama, Ahmed Orabi, Aalaa Saad
The use of antibiotics in farm management (growing crops and raising animals) has become a major area of concern. Its implications is the consequent emergence of antibiotic resistant bacteria (ARB) and accordingly their access into the human food chain with passage of antibiotic resistance genes (ARG) to the normal human intestinal microbiota and hence to other pathogenic bacteria causative human disease. Therefore, we pursued in this study to unravel the frequency and the quinolone resistance determining region, mecA and cfr genes of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27919495/clinical-characteristics-of-patients-with-multiple-sclerosis-enrolled-in-a-new-registry-in-egypt
#3
Magd Zakaria, Dina A Zamzam, Mohamed A Abdel Hafeez, Mahmoud S Swelam, Shaimaa S Khater, Mai F Fahmy, Ayman Abdel Hady, Mohamed M Fouad, Azza Abdel Nasser, Hany Aref, Mohsen Gadallah
BACKGROUND: Epidemiological studies of multiple sclerosis (MS) are lacking in Egypt. OBJECTIVE: To study the characteristics of Egyptian patients with multiple sclerosis in a new registry in a major tertiary referral centre in Cairo, Egypt. SUBJECT AND METHODS: Patients were from the project MS database of the Multiple Sclerosis Unit at Ain Shams University Hospitals (N=950). We conducted a detailed medical history and examination including the Expanded Disability Status Scale (EDSS)...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27918316/cognitive-impairment-and-tramadol-dependence
#4
Medhat M Bassiony, Usama M Youssef, Mervat S Hassan, Ghada M Salah El-Deen, Hayam El-Gohari, Mohamed Abdelghani, Ahmed Abdalla, Dalia H Ibrahim
BACKGROUND AND OBJECTIVE: Cognitive impairment is one of the consequences of substance abuse. Tramadol abuse is a public health problem in Egypt. The objective of this study was to estimate the prevalence and correlates of cognitive impairment among tramadol-abuse patients and control subjects. METHODS: This study included 100 patients with tramadol abuse and 100 control subjects (matched for age, sex, and education) who were recruited from Zagazig University Hospital, Egypt...
December 1, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27917323/development-and-evaluation-of-a-novel-vaccine-against-prevalent-invasive-multi-drug-resistant-strains-of-streptococcus-pneumoniae
#5
Rehab H Bahy, Hayam M Hamouda, Amal S Shahat, Aymen S Yassin, Magdy A Amin
Streptococcus pneumoniae is a pathogen that causes serious invasive infections, such as septicemia, meningitis and pneumonia in addition to mild upper respiratory tract infections. Protection from pneumococcal diseases is thought to be mediated mainly by serotype-specific antibodies to capsular antigens. Pneumococcal conjugate vaccine consists of sugars (polysaccharides) from the capsule of the bacterium S. pneumoniae that are conjugated to a carrier protein. Three pneumococcal conjugated vaccines, each directed against a group of serotypes, are registered in Egypt; however, local vaccine production is required to cover the most prevalent serotypes...
2016: PeerJ
https://www.readbyqxmd.com/read/27917042/first-record-of-the-genus-pycnodictya-with-its-subspecies-p-galinieri-galinieri-from-egypt-orthoptera-acrididae
#6
REVIEW
Asmaa A Haggag
The band-winged Pycnodictya galinieri galinieri (Reiche & Fairmaire, 1849) and its genus Pycnodictya Stål, 1873 (Orthoptera: Acrididae: Oedipodinae) are recorded for the first time for the Egyptian fauna. The species was collected from Gabal Elba, in the southeastern corner of Egypt. This record expands the known distributional range of Pycnodictya galinieri towards the north of Africa. Descriptions of the genus and the Egyptian subspecies are given using multiple diagnostic characters. The descriptions are supplemented by drawings and photographs of the specimen collected...
2016: ZooKeys
https://www.readbyqxmd.com/read/27914930/biological-fitness-and-natural-selection-of-amantadine-resistant-variants-of-avian-influenza-h5n1-viruses
#7
E M Abdelwhab, Jutta Veits, Thomas C Mettenleiter
Outbreaks caused by the highly pathogenic H5N1 avian influenza virus (A/H5N1) devastated the poultry industry in several countries and posed a significant pandemic threat. In addition to culling of infected poultry and vaccination, amantadine has been applied in poultry in some countries to control the spread of the virus. The prevalence of the amantadine resistance marker at position 31 (Ser31Asn) of the M2 protein increased over time. However, little is known about the biological fitness and selection of H5N1 amantadine resistant strains over their sensitive counterparts...
November 30, 2016: Virus Research
https://www.readbyqxmd.com/read/27911983/fibrin-glue-versus-sutures-for-conjunctival-autografting-in-primary-pterygium-surgery
#8
REVIEW
Vito Romano, Mario Cruciani, Luigi Conti, Luigi Fontana
BACKGROUND: Pterygium, a growth of the conjunctiva over the cornea, is a progressive disease leading in advanced stages to visual impairment, restriction of ocular motility, chronic inflammation and cosmetic concerns. Surgical removal is the treatment of choice, but recurrence can be a problem. Currently the best surgical option in terms of recurrence is conjunctival autograft. To date the most common surgical methods of attaching conjunctival autografts to the sclera are through suturing or fibrin glue...
December 2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27906985/egypt-its-artists-intellectuals-and-neglected-tropical-diseases
#9
EDITORIAL
Peter J Hotez, Moustapha Kassem
No abstract text is available yet for this article.
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27906040/identity-of-fasciola-spp-in-sheep-in-egypt
#10
Said Amer, Ahmed ElKhatam, Shereif Zidan, Yaoyu Feng, Lihua Xiao
BACKGROUND: In Egypt, liver flukes, Fasciola spp. (Digenea: Fasciolidae), have a serious impact on the farming industry and public health. Both Fasciola hepatica and Fasciola gigantica are known to occur in cattle, providing the opportunity for genetic recombination. Little is known on the identity and genetic variability of Fasciola populations in sheep. METHODS: This study was performed to determine the prevalence of liver flukes in sheep in Menofia Province as a representative area of the delta region in Egypt, as measured by postmortem examination of slaughtered animals at three abattoirs...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27905631/-notes-for-a-history-of-hygiene-taken-from-the-bible
#11
Walter Ledermann
Reading once more the Gospels, we found a discussion between Jesus and the Pharisee about the hand washing, this golden rule of medicine, and then, with the help of Thomas Mann, we began a search for other notes on hygiene in the Bible. For the return from Egypt to the Promised Land, Moses established several rules for his people, some of them disguised as religious principles, concerning elimination of excreta, healthy and poisonous foods, isolation in case of contagious diseases (leprosy, gonorrhea), decontamination of clothes and houses, and many others that now seem to us ahead his time...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27903065/predominance-and-geo-mapping-of-avian-influenza-h5n1-in-poultry-sectors-in-egypt
#12
Abdelsatar Arafa, Ihab El-Masry, Shereen Khoulosy, Mohammed K Hassan, Moussa Soliman, Olubunmi G Fasanmi, Folorunso O Fasina, Gwenaelle Dauphin, Juan Lubroth, Yilma M Jobre
Highly pathogenic avian influenza (HPAI) virus of the H5N1 subtype has been enzootic in the Egyptian poultry with significant human infections since 2008. This work evaluates the epidemiological and virological information from February 2006 to May 2015 in spatial and temporal terms. Only data with confirmed HPAI H5N1 sub-type were collected, and matched with the epidemiological data from various spatially and temporally-dispersed surveillances implemented between 2006 and 2015. Spatio-temporal analysis was conducted on a total of 3338 confirmed H5N1 HPAI poultry disease outbreaks and outputs described based on transmission patterns, poultry species, production types affected, trade, geographic and temporal distributions in Egypt...
November 28, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27902900/sensitivity-and-specificity-estimation-for-the-clinical-diagnosis-of-highly-pathogenic-avian-influenza-in-the-egyptian-participatory-disease-surveillance-program
#13
C Verdugo, I El Masry, Y Makonnen, H Hannah, F Unger, M Soliman, S Galal, J Lubroth, D Grace
Many developing countries lack sufficient resources to conduct animal disease surveillance. In recent years, participatory epidemiology has been used to increase the cover and decrease the costs of surveillance. However, few diagnostic performance assessments have been carried out on participatory methods. The objective of the present study was to estimate the diagnostic performance of practitioners working for the Community-Based Animal Health and Outreach (CAHO) program, which is a participatory disease surveillance system for the detection of highly pathogenic avian influenza outbreaks in Egypt...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902731/queen-nefertari-the-royal-spouse-of-pharaoh-ramses-ii-a-multidisciplinary-investigation-of-the-mummified-remains-found-in-her-tomb-qv66
#14
Michael E Habicht, Raffaella Bianucci, Stephen A Buckley, Joann Fletcher, Abigail S Bouwman, Lena M Öhrström, Roger Seiler, Francesco M Galassi, Irka Hajdas, Eleni Vassilika, Thomas Böni, Maciej Henneberg, Frank J Rühli
Queen Nefertari, the favourite Royal Consort of Pharaoh Ramses II (Ancient Egypt, New Kingdom, 19th Dynasty c. 1250 BC) is famous for her beautifully decorated tomb in the Valley of the Queens. Her burial was plundered in ancient times yet still many objects were found broken in the debris when the tomb was excavated. Amongst the found objects was a pair of mummified legs. They came to the Egyptian Museum in Turin and are henceforth regarded as the remains of this famous Queen, although they were never scientifically investigated...
2016: PloS One
https://www.readbyqxmd.com/read/27902350/novel-reassortant-h9n2-viruses-in-pigeons-and-evidence-for-antigenic-diversity-of-h9n2-viruses-isolated-from-quails-in-egypt
#15
Ahmed Kandeil, Rabeh El-Shesheny, Asmaa Maatouq, Yassmin Moatasim, Zhipeng Cai, Pamela McKenzie, Richard Webby, Ghazi Kayali, Mohamed Ahmed Ali
The endemicity of avian influenza viruses (AIVs) among Egyptian poultry represents a public health risk. Co-circulation of low pathogenic AIV H9N2 subtype with highly pathogenic AIV H5N1 subtype in Egyptian farms potentiates the possibility to generate novel reassortant viruses. Herein, the genetic characteristics of surface glycoproteins of 59 Egyptian H9N2 viruses, isolated between 2013 and 2015, were analyzed. To elucidate the potential of genetic reassortment, 10 H9N2 isolates were selected based on different avian hosts (chickens, ducks, pigeons and quails) and conducted for phylogenetic analyses of full genome sequences...
November 11, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902339/progressive-glycosylation-of-the-hemagglutinin-of-avian-influenza-h5n1-modulates-virus-replication-virulence-and-chicken-to-chicken-transmission-without-significant-impact-on-antigenic-drift
#16
El-Sayed M Abdelwhab, Jutta Veits, Kerstin Tauscher, Mario Ziller, Christian Grund, Mohamed K Hassan, Momtaz Shaheen, Timm C Harder, Jens P Teifke, Jürgen Stech, Thomas C Mettenleiter
Highly pathogenic H5N1 avian influenza virus (A/H5N1) devastated the poultry industry and continues to pose a pandemic threat. Studying the progressive genetic changes in A/H5N1 after long term circulation in poultry may help to better understand A/H5N1 biology in birds. A/H5N1 clade 2.2.1.1 antigenic drift viruses have been isolated from vaccinated commercial poultry in Egypt. They exhibit a peculiar stepwise accumulation of glycosylation sites (GS) in the hemagglutinin (HA) with viruses carrying, beyond the conserved 5 GS, additional GS at amino acid residues 72, 154, 236 and 273 resulting in 6, 7, 8 or 9 GS in the HA...
October 28, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27896822/simeprevir-in-combination-with-sofosbuvir-in-treatment-na%C3%A3-ve-and-experienced-patients-with-hepatitis-c-virus-genotype-4-infection-a-phase-iii-open-label-single-arm-study-pluto
#17
M Buti, J L Calleja, S Lens, M Diago, E Ortega, J Crespo, R Planas, M Romero-Gómez, F G Rodríguez, J M Pascasio, B Fevery, D Kurland, C Corbett, R Kalmeijer, W Jessner
BACKGROUND: Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and subsequent hepatocellular carcinoma. HCV genotype 4 is found widely in the Middle East, Egypt and Africa, and has also spread into Europe. There are limited data available regarding the use of direct-acting antiviral agents in HCV genotype 4-infected patients with cirrhosis. AIM: The Phase III, open-label, single-arm PLUTO study evaluated the efficacy and safety of 12 weeks of simeprevir (HCV NS3/4A protease inhibitor) plus sofosbuvir (HCV nucleotide-analogue NS5B polymerase inhibitor) in treatment-naïve and (peg)interferon ± ribavirin-experienced HCV genotype 4-infected patients, with or without compensated cirrhosis...
November 29, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27895363/a-systematic-review-of-epidemiological-literature-on-the-eye-health-of-marginalized-fishing-populations
#18
Khabir Ahmad, Anthony B Zwi, Daniel J M Tarantola, Bal Chand
A systematic review was conducted in December 2013 to examine the extent to which health research has been focused on the eye health issues of fishing communities. We searched multiple databases to identify relevant citations, using a combination of Medical Subject Headings (MeSH) and text words representing eye health, fishing populations and measures of disease frequency. The search yielded only 4 studies, described in 5 articles. Three studies (one each in Turkey, Egypt and Spain) provided data on self-reported eye problems in fishermen or fishery workers, with prevalence ranging from 38% to 81%...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27894198/a-randomized-clinical-trial-of-the-efficacy-of-single-versus-double-daily-dose-of-oral-iron-for-prevention-of-iron-deficiency-anemia-in-women-with-twin-gestations
#19
Mohammed K Ali, Ahmed M Abbas, Ahmed M Abdelmagied, Ghada E Mohammed, Osama S Abdalmageed
OBJECTIVE: The study aims to assess the efficacy of single versus double-daily oral iron dose on prevention of iron deficiency anemia in women with twin gestations. MATERIALS AND METHODS: A randomized controlled trial (NCT02858505) conducted at Woman's Health Hospital, Assiut, Egypt, between the August 2015 and June 2016 included 120 non-anemic pregnant women with twin gestations in the first trimester. Women were randomly assigned to either group I (27 mg elemental iron) or group II (54 mg elemental iron) daily starting from 12 weeks of pregnancy till 36 weeks...
November 28, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27893200/clinical-impact-of-overexpression-of-foxp3-and-wt1-on-disease-outcome-in-egyptian-acute-myeloid-leukemia-patients
#20
Magda Assem, Ahmed Osman, Eman Kandeel, Reham Elshimy, Hanan Nassar, Radwa Ali
Background: In the last decade, it has become clear that change of gene expression may alter the hematopoietic cell quiescent state and consequently play a major role in leukemogenesis. WT1 is known to be a player in acute myeloid leukemia (AML) and FOXP3 has a crucial role in regulating the immune response. Objectives: To evaluate the impact of overexpression of WT1and FOXP3 genes on clinical course in adult and pediatric AML patients in Egypt. Patients and methods: Bone marrow and peripheral blood samples were obtained from 97 de novo non M3 AML patients (63 adult and 34 pediatric)...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
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