Zhe Wu, Lisa G Spencer, Winston Banya, John Westoby, Veronica A Tudor, Pilar Rivera-Ortega, Nazia Chaudhuri, Ira Jakupovic, Brijesh Patel, Muhunthan Thillai, Alex West, Marlies Wijsenbeek, Toby M Maher, Jacky A Smith, Philip L Molyneaux
BACKGROUND: Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease, with most patients reporting cough. Currently, there are no proven treatments. We examined the use of low dose controlled-release morphine compared with placebo as an antitussive therapy in individuals with idiopathic pulmonary fibrosis. METHODS: The PACIFY COUGH study is a phase 2, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial done in three specialist centres in the UK...
April 2024: Lancet Respiratory Medicine