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Chronic cough

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https://www.readbyqxmd.com/read/29350763/molecular-allergen-profiling-in-horses-by-microarray-reveals-fag-e-2-from-buckwheat-as-a-frequent-sensitizer
#1
L Einhorn, G Hofstetter, S Brandt, E K Hainisch, I Fukuda, K Kusano, A Scheynius, I Mittermann, Y Resch-Marat, S Vrtala, R Valenta, E Marti, C Rhyner, R Crameri, R Satoh, R Teshima, A Tanaka, H Sato, H Matsuda, I Pali-Schöll, E Jensen-Jarolim
BACKGROUND: Companion animals are also affected by IgE-mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles. METHODS: Custom-designed allergen microarray was produced on the basis of the IimmunoCAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity...
January 19, 2018: Allergy
https://www.readbyqxmd.com/read/29345232/a-rare-cause-of-chronic-cough
#2
Gero Schulze, Hans-Jürgen Seyfarth
No abstract text is available yet for this article.
January 8, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29337269/inhibitors-of-phosphodiesterases-in-the-treatment-of-cough
#3
REVIEW
Juraj Mokry, Anna Urbanova, Martin Kertys, Daniela Mokra
A group of 11 enzyme families of metalophosphohydrolases called phosphodiesterases (PDEs) is responsible for a hydrolysis of intracellular cAMP and cGMP. Xanthine derivatives (methylxanthines) inhibit PDEs without selective action on their single isoforms and lead to many pharmacological effects, e.g. bronchodilation, anti-inflammatory and immunomodulating effects, and thus they can modulate the cough reflex. Contrary, selective PDE inhibitors have been developed to inhibit PDE isoforms with different pharmacological effects based on their tissue expression...
January 11, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29337268/the-double-sidedness-of-cough-in-the-elderly
#4
REVIEW
Ha-Kyeong Won, Sol-Ji Yoon, Woo-Jung Song
Cough is a physiological reflex to protect airways against aspiration, but also it is one of the most frequent problems that lead patients to seek medical care. Chronic cough is more prevalent in the elderly than younger subjects, and more challenging to manage due to frequent comorbidities and possible side effects from drug treatment. Meanwhile, cough reflex does not decrease with natural aging but is often impaired by pathologic conditions like stroke. The impairment in cough reflex may lead to fatal complication like aspiration pneumonia...
January 11, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29332652/initial-airflow-obstruction-in-new-cases-of-pulmonary-tuberculosis-complication-comorbidity-or-missed
#5
Andrii Dudnyk, Svitlana Blyzniuk, Oleksandr Pavel'chuk, Olena Zakharchenko, Dmytro Butov, Sergiі Zaіkov
Tuberculosis (TB) may have a similar spirometry findings as a chronic obstructive pulmonary disease but the prevalence of TB-induced airflow obstruction (AO) is still unknown. OBJECTIVES: To measure frequency of AO in new TB cases at the beginning of treatment and to evaluate factors associated with obstructive abnormalities following TB diagnosis. MATERIALS AND METHODS: 317 patients that have no history of prior AO were recruited into the study with a median age of 39...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29326318/long-term-benefits-of-airway-clearance-in-bronchiectasis-a-randomised-placebo-controlled-trial
#6
Gerard Muñoz, Javier de Gracia, Maria Buxó, Antonio Alvarez, Montserrat Vendrell
Keeping airways clear of mucus by airway clearance techniques seems essential in bronchiectasis treatment, although no placebo-controlled trials or any studies lasting longer than 3 months have been conducted. We evaluate the efficacy of the ELTGOL (slow expiration with the glottis opened in the lateral posture) technique over a 1-year period in bronchiectasis patients with chronic expectoration in a randomised placebo-controlled trial.Patients were randomised to perform the ELTGOL technique (n=22) or placebo exercises (n=22) twice-daily (ClinicalTrials...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29326052/sensitivity-of-airway-cough-related-afferents-is-influenced-by-female-sex-hormones
#7
Natalia Kavalcikova-Bogdanova, Lea Kovacikova, Tomas Buday, Kamil Biringer, Jana Sivakova, Vladimir Calkovsky, Martina Antosova, Jana Plevkova
Chronic hypersensitivity cough syndrome affects mainly postmenopausal women; however, the pathogenesis of cough hypersensitivity in this demographic is not entirely understood. The role of sex hormones in cough has never been studied in detail; however, sex hormones seem to play an important role in the lung health of women.
January 8, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29324936/the-impact-of-lung-perfusion-scintigraphy-in-the-emergency-management-of-patients-with-suspected-pulmonary-embolism
#8
Cristina Ferrari, Alessandra Cimino, Giacomo Bianco, Francesca Iuele, Alessandra Di Palo, Margherita Fanelli, Artor Niccoli-Asabella, Giuseppe Rubini
OBJECTIVE: Pulmonary Embolism (PE) is an emergency condition that requires immediate treatment. As the symptoms and the risk factors are nonspecific, PE differential diagnosis is often required. Even if angio-CT is considered the gold standard for PE diagnosis, the frequent allergic condition and/or chronic renal failure of patients make, in most cases, not possible the use of contrast enhancement in emergency with even more increasing use of Lung Perfusion Scintigraphy (LPS), as a simple and fast examination with no preparation/contraindication...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29320941/progressive-delayed-respiratory-complications-of-sulfur-mustard-poisoning-in-43-iranian-veterans-three-decades-after-exposure
#9
E Darchini-Maragheh, M Balali-Mood, M Malaknezhad, S R Mousavi
The most common delayed complication of sulfur mustard (SM) poisoning has been observed in the respiratory tracts. It was thus aimed to investigate the delayed respiratory complications in SM-exposed patients around 25 years before the study. Forty-three veterans with more than 25% disability of due to SM poisoning were investigated. Clinical examinations as well as pulmonary function test (PFT) were performed. High-resolution computed tomography (HRCT) of the lungs was done as clinically indicated. Triad of chronic cough, dyspnea, and expectoration were the most common symptoms that were recorded in 88...
February 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29319029/clinical-and-pulmonary-functions-profiling-of-patients-with-chronic-obstructive-pulmonary-disease-experiencing-frequent-acute-exacerbations
#10
Prem Parkash Gupta, Manjunath B Govidagoudar, Rohtas Yadav, Dipti Agarwal
PURPOSE: The present study aimed at clinical and pulmonary functions profiling of patients with chronic obstructive pulmonary disease (COPD) to anticipate future exacerbations. METHODS: The study included 80 COPD patients; 40 patients had ≥2 acute exacerbations during preceding 1 year (frequent exacerbation [FECOPD] group) and 40 patients had <2 acute exacerbations during preceding 1 year (infrequent exacerbation [I-FECOPD] group). Clinical profile, sputum microbiology, blood gas analysis, spirometric indices, and diffusion capacity (transfer test) variables were assessed...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29318026/broncholithiasis-associated-with-lower-airway-inflammation-and-subsequent-pyothorax-in-a-cat
#11
Ferran Valls Sanchez, Jennifer Stewart, Catherine Bovens, Jordi Puig
Case summary: A 12-year-old female spayed domestic shorthair cat presented with history of a long-term chronic cough that had worsened during the previous 2 months. Thoracic radiographs revealed numerous mineral opacities throughout the lung fields. Multiple bronchial plugs of pale yellow material were present on bronchoscopy, consistent with broncholithiasis. Bronchoalveolar lavage cytology revealed a mild neutrophilic inflammation and bacterial culture was negative. The cat was diagnosed with chronic inflammatory lower airway disease and broncholithiasis, suspected to be due to mineralisation of secretions in the bronchial lumen...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29316973/kartagener-s-syndrome-a-case-report
#12
Abilo Tadesse, Hailemariam Alemu, Mezgebu Silamsaw, Yonathan Gebrewold
BACKGROUND: Kartagener's syndrome is a subset of primary ciliary dyskinesia, an autosomal recessive inherited disorder characterized by the clinical triad of chronic sinusitis, bronchiectasis, and situs inversus. Abnormal ciliary structure or function leading to impaired ciliary motility is the main pathophysiologic problem in Kartagener's syndrome. CASE PRESENTATION: A 24-year-old man from Gondar town, North-West Ethiopia, presented to University of Gondar Hospital with recurrent episodes of nasal congestion with itching and paranasal discomfort, and productive cough for more than a decade...
January 10, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29314737/airway-inflammation-in-sickle-cell-disease-a-translational-perspective
#13
REVIEW
Aliva De, Deepa Manwani, Deepa Rastogi
Asthma and sickle cell disease (SCD) are common chronic conditions in children of African ancestry that are characterized by cough, wheeze, and obstructive patterns on pulmonary function. Pulmonary function testing in children with SCD has estimated a prevalence of obstructive lung disease ranging from 13% to 57%, and airway hyper-responsiveness of up to 77%, independent of a diagnosis of asthma. Asthma co-existing with SCD is associated with increased risk of acute chest syndrome (ACS), respiratory symptoms, pain episodes, and death...
January 4, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29310885/characteristics-of-a-treatment-seeking-population-in-a-private-practice-community-voice-clinic-an-epidemiologic-study
#14
Christopher R Watts, Kristie Knickerbocker
OBJECTIVE: The purpose of this study was to evaluate epidemiologic characteristics of a treatment-seeking population referred to a private practice community voice clinic. STUDY DESIGN: This is a retrospective cohort study. METHODS: Patient files representing evaluation referrals over a 28-month period were reviewed. Variables tabulated from records included disorder diagnosis, age, gender, perceptual voice quality ratings, and self-perceived voice handicap at initial evaluation...
January 5, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29305552/venetoclax-for-patients-with-chronic-lymphocytic-leukemia-who-progressed-during-or-after-idelalisib-therapy
#15
Steven Coutre, Michael Choi, Richard R Furman, Herbert Eradat, Leonard Heffner, Jeffrey A Jones, Brenda Chyla, Lang Zhou, Suresh Agarwal, Tina Waskiewicz, Maria Verdugo, Rod A Humerickhouse, Jalaja Potluri, William G Wierda, Matthew S Davids
B-cell receptor pathway inhibitors (BCRi) have transformed treatment for chronic lymphocytic leukemia (CLL); however, efficacy of therapies for patients whose disease is refractory to/relapses after (R/R) BCRi is unknown. Venetoclax is a selective, orally bioavailable BCL-2 inhibitor with activity in patients with CLL, including those who are heavily pretreated or have 17p deletion. This phase 2 study prospectively evaluated venetoclax in patients with R/R CLL after ibrutinib or idelalisib; here we report on patients who received idelalisib as the last BCRi prior to enrollment...
January 5, 2018: Blood
https://www.readbyqxmd.com/read/29303602/melatonin-attenuates-chronic-cough-mediated-by-oxidative-stress-via-transient-receptor-potential-melastatin-2-in-guinea-pigs-exposed-to-particulate-matter-2-5
#16
Zhenjun Ji, Zhen Wang, Zhe Chen, Hao Jin, Chen Chen, Senlin Chai, Haining Lv, Ling Yang, Yakun Hu, Rong Dong, Kefang Lai
The aim of this study was to investigate the effects of melatonin on oxidative stress, the expression of transient receptor potential melastatin-2 (TRPM2) in guinea pig brains, and the influence of melatonin on oxidative stress in lungs and airway inflammation induced by particulate matter 2.5 (PM2.5). A particle suspension (0.1 g/ml) was nasally administered to the guinea pigs to prepare a PM2.5 exposure model. Cough frequency and cough incubation period were determined through RM6240B biological signal collection and disposal system...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29303282/-extrinsic-allergic-alveolitis-minimum-for-clinical-practice
#17
Martina Šterclová
Extrinsic allergic alveolitis (EAA) represent a group of diseases, that develop in susceptible individuals after repeated exposure to usually organic inhalation antigen. Patient may be in contact with these agents both in occupational and in home environment, as well as during free time activities and hobbies. The course of the disease is highly variable - EAA may have dramatic symptoms with fever, cough and severe dyspnoea as well as may be presented with slowly increasing dyspnoea and chronic cough. The more inconspicious are the symptoms of chronic EAA, the more problematic its treatment may be...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29301855/gene-editing-as-a-promising-approach-for-respiratory-diseases
#18
Yichun Bai, Yang Liu, Zhenlei Su, Yana Ma, Chonghua Ren, Runzhen Zhao, Hong-Long Ji
Respiratory diseases, which are leading causes of mortality and morbidity in the world, are dysfunctions of the nasopharynx, the trachea, the bronchus, the lung and the pleural cavity. Symptoms of chronic respiratory diseases, such as cough, sneezing and difficulty breathing, may seriously affect the productivity, sleep quality and physical and mental well-being of patients, and patients with acute respiratory diseases may have difficulty breathing, anoxia and even life-threatening respiratory failure. Respiratory diseases are generally heterogeneous, with multifaceted causes including smoking, ageing, air pollution, infection and gene mutations...
January 4, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29288742/the-research-of-the-possible-mechanism-and-the-treatment-for-capsaicin-induced-cough
#19
Li Zhang, Tieying Sun, Longteng Liu, Lifang Wang
Unexplained chronic cough (UCC) affects millions of patients worldwide. New therapeutic approaches to this condition are urgently needed, since current treatment options provide only symptomatic relief. Cough reflex hypersensitivity has been shown to play an important role in the pathogenesis of UCC. The transient receptor potential vanilloid type 1 (TRPV1) is present on peripheral terminals of airway sensory nerves and modulation of its activity represents a potential target for the pharmacological treatment of UCC...
December 27, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29286433/methodology-for-sputum-induction-and-laboratory-processing
#20
Julien Guiot, Sophie Demarche, Monique Henket, Virginie Paulus, Sophie Graff, Florence Schleich, Jean-Louis Corhay, Renaud Louis, Catherine Moermans
The technique of sputum induction and processing is a recognized non-invasive method allowing the collection and analysis of cells from the airways, which is interesting in various respiratory diseases like asthma, chronic obstructive pulmonary disease (COPD), chronic cough, or idiopathic pulmonary fibrosis. This technique is well tolerated, safe and non-invasive, but is currently limited to research services and specialized centers in clinical practice because it is technically demanding, time-consuming, and requires trained staff...
December 17, 2017: Journal of Visualized Experiments: JoVE
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