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https://www.readbyqxmd.com/read/28445779/the-acute-cardiorespiratory-effects-of-centrally-injected-arachidonic-acid-the-mediation-of-prostaglandin-e-d-and-f2%C3%AE
#1
Leman Gizem Erkan, Burcin Altinbas, Gokcen Guvenc, Begum Aydin, Nasir Niaz, Murat Yalcin
Arachidonic acid (AA), which is released from synaptic membrane phospholipid by neuroreceptor-initiated activation of phospholipase A2, is abundant in the brain and works as a neurotransmitter and/or neuromodulator in the central nervous system. Recently we reported that centrally injected AA generated pressor and hyperventilation effects by activating thromboxane A2 (TXA2) signaling pathway. The present study was designed to investigate the mediation of other metabolites of AA such as prostaglandin (PG) D, PGE and PGF2α alongside TXA2 in the AA-evoked cardiorespiratory effects in anaesthetized rats...
April 23, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28443830/paco-sub-2-sub-measurement-in-cerebral-haemodynamics-face-mask-or-nasal-cannulae
#2
Jatinder Singh Minhas, Thompson Robinson, Ronney Panerai
Objective PaCO2 affects cerebral blood flow (CBF) and its regulatory mechanisms, but the effects of CO2 measurement technique on cerebrovascular parameters are unknown. In order to determine if the two most commonly used approaches, face mask (FM) or nasal cannulae (NC), are interchangeable or not, we tested the hypothesis that the use of FM versus NC does not lead to significant differences in CO2-related systemic and cerebrovascular parameters. Approach Recordings of CBF velocity (CBFV), blood pressure (BP), heart rate, and end-tidal CO2 (EtCO2) were performed in 42 subjects during normocapnia (FM or NC) and 5% CO2 inhalation (FM) or hyperventilation (NC)...
April 26, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28438446/the-association-of-hemodialysis-and-survival-in-intubated-salicylate-poisoned-patients
#3
Daniel J McCabe, Jenny J Lu
INTRODUCTION: Salicylate poisonings are common due to their multiple uses and wide availability. The variation of presenting symptoms contributes to inconsistent treatments in the emergency department. Patients with severe salicylate overdose require a high minute ventilation. Early in the course of an overdose, a patient will require hyperventilation. If they become too fatigued to compensate, mechanical ventilation may be needed. It can be impossible to recreate such a high minute ventilation with mechanical ventilation...
April 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28435989/aggressive-medical-management-of-acute-traumatic-subdural-hematomas-before-emergency-craniotomy-in-patients-presenting-with-bilateral-unreactive-pupils-a-cohort-study
#4
Arturo Chieregato, Alessandra Venditto, Emanuele Russo, Costanza Martino, Giovanni Bini
BACKGROUND: The outcome of patients with severe traumatic brain injury (TBI) and acute traumatic subdural hematoma (aSDH) admitted to the emergency room with bilaterally dilated, unreactive pupils (bilateral mydriasis) is notoriously poor. METHODS: Of 2074 TBI patients consecutively admitted to our facility between 1997 and 2012, 115 had a first CT scan with aSDH, unreactive bilateral mydriasis, and a Glasgow Coma Score of 3 or 4. Sixty-two patients were unoperated and died within hours or a few days...
April 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28431383/protocolized-hyperventilation-enhances-electroconvulsive-therapy
#5
Aida de Arriba-Arnau, Antonia Dalmau, Virginia Soria, Neus Salvat-Pujol, Carmina Ribes, Ana Sánchez-Allueva, José Manuel Menchón, Mikel Urretavizcaya
BACKGROUND: Hyperventilation is recommended in electroconvulsive therapy (ECT) to enhance seizures and to increase patients' safety. However, more evidence is needed regarding its effects and the optimum method of application. METHODS: This prospective study involving 21 subjects compared two procedures, protocolized hyperventilation (PHV) and hyperventilation as usual (HVau), applied to the same patient in two consecutive sessions. Transcutaneous partial pressure of carbon dioxide (TcPCO2) was measured throughout all sessions...
April 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28431366/efficacy-and-safety-of-a-video-eeg-protocol-for-genetic-generalized-epilepsies
#6
Luciana Rodrigues De Marchi, Jeana Torres Corso, Ana Carolina Zetehaku, Carina Gonçalves Pedroso Uchida, Mirian Salvadori Bittar Guaranha, Elza Márcia Targas Yacubian
INTRODUCTION: Video-EEG has been used to characterize genetic generalized epilepsies (GGE). For best performance, sleep recording, photic stimulation, hyperventilation, and neuropsychological protocols are added to the monitoring. However, risks and benefits of these video-EEG protocols are not well established. The aim of this study was to analyze the efficacy and safety of a video-EEG neuropsychological protocol (VNPP) tailored for GGE and compare its value with that of routine EEG (R-EEG)...
April 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28419017/the-evaluation-of-trauma-care-the-comparison-of-2-high-level-pediatric-emergency-departments-in-the-united-states-and-turkey
#7
Alkan Bal, Michael Cooper, Amanda Lee, Murat Anil, Halim Hennes
OBJECTIVE: The purpose of the study is to compare the outcomes of pediatric trauma patients with motor vehicle crashes (MVCs) and motor vehicle versus pedestrian crashes (MPCs) at a level 1 pediatric trauma center in the United States and a pediatric trauma center in Turkey. METHODS: The medical records of all pediatric MVC and MPC subjects presenting to the emergency departments (EDs) of a level 3 hospital in Turkey (Izmir Tepecik Training and Research Hospital [ITTRH]) and a level 1 pediatric trauma center in the United States (Children's Medical Center Dallas [CMCD]) over a 1-year period were reviewed...
April 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28417842/blood-injection-injury-b-i-i-specific-phobia-affects-the-outcome-of-hypoxic-challenge-testing
#8
Kristofer J Spurling, Veronica P McGoldrick
BACKGROUND: Blood-injection-injury (B-I-I) phobia is capable of producing inaccurate hypoxic challenge testing results due to anxiety-induced hyperventilation. CASE REPORT: A 69-yr-old woman with a history of hypersensitivity pneumonitis, restrictive spirometry, exercise desaturation requiring supplementary oxygen on mobilizing, reduced DLco, and B-I-I phobia was referred for hypoxic challenge testing (HCT) to assess in-flight oxygen requirements. HCT was performed by breathing a 15% FIo2 gas mixture, simulating the available oxygen in ambient air onboard aircraft pressurized to an equivalent altitude of 8000 ft...
May 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28407251/investigating-hyperventilation-syndrome-in-patients-suffering-from-empty-nose-syndrome
#9
David Mangin, Emilie Bequignon, Francoise Zerah-Lancner, Daniel Isabey, Bruno Louis, Serge Adnot, Jean-François Papon, André Coste, Laurent Boyer, Marie Devars du Mayne
OBJECTIVES/HYPOTHESIS: Patients with empty nose syndrome (ENS) following turbinate surgery often complain about breathing difficulties. We set out to determine if dyspnea in patients with ENS was associated with hyperventilation syndrome (HVS). We hypothesized that lower airway symptoms in ENS could be explained by HVS. STUDY DESIGN: Observational prospective study. METHODS: All consecutive patients referred to our center for ENS over 1 year were invited to participate...
April 13, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28403407/apnoeic-oxygenation-in-adults-under-general-anaesthesia-using-transnasal-humidified-rapid-insufflation-ventilatory-exchange-thrive-a-physiological-study
#10
I-M Gustafsson, Å Lodenius, J Tunelli, J Ullman, M Jonsson Fagerlund
Background.: Apnoeic oxygenation during anaesthesia has traditionally been limited by the rapid increase in carbon dioxide and subsequent decrease in pH. Using a Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) technique a slower increase in carbon dioxide than earlier studies was seen. Notably, apnoeic oxygenation using THRIVE has not been systematically evaluated with arterial blood gases or in patients undergoing laryngeal surgery. The primary aim of this study was to characterize changes in arterial P O 2 , P CO 2 and pH during apnoeic oxygenation using THRIVE under general anaesthesia...
April 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28396201/pharmacological-but-not-genetic-alteration-of-neural-epo-modifies-the-co2-h-central-chemosensitivity-in-postnatal-mice
#11
Sofien Laouafa, Anne-Sophie Perrin-Terrin, Florine Jeton, Elizabeth Elliot-Portal, Rose Tam, Laurence Bodineau, Nicolas Voituron, Jorge Soliz
Cerebral erythropoietin (Epo) plays a crucial role for respiratory control in newborn rodents. We showed previously that soluble Epo receptor (sEpoR: an Epo antagonist) reduces basal ventilation and hypoxic hyperventilation at postnatal day 10 (P10) and in adult mice. However, at these ages (P10 and adulthood), Epo had no effect on central chemosensitivity. Nevertheless, it is known that the sensitivity to CO2/H(+) during the mammalian respiratory network maturation process is age-dependent. Accordingly, in this study we wanted to test the hypothesis that cerebral Epo is involved in the breathing stimulation induced by the activation of central CO2/H(+) chemoreceptors at earlier postnatal ages...
April 8, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28393459/lunhab-interactive-effects-of-a-10-day-sustained-exposure-to-hypoxia-and-bedrest-on-aerobic-exercise-capacity-in-male-lowlanders
#12
Michail E Keramidas, Igor B Mekjavic, Ola Eiken
The study examined the interactive effects of a 10-day exposure to hypoxia and bedrest on the whole body peak oxygen uptake (V˙O2 peak ) during maximal exercise, and on skeletal-muscle and cerebral oxygenation during submaximal exercise. Nine males underwent three 10-day confinements, in a Latin-square order: (i) a normoxic bedrest [NBR; partial pressure of inspired O2 (PI O2 ) = 134.2 ± 0.7 mmHg], (ii) a hypoxic bedrest (HBR; PI O2  = 102.9 ± 0.1 mmHg at day 1, 91.5 ± 1.2 mmHg at days 3-10), and (iii) a hypoxic ambulation (HAMB; PI O2 as in HBR)...
April 9, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28392039/effect-of-arterial-puncture-on-ventilation
#13
Ashima Synghal Sahni, Hemil Gonzalez, Aiman Tulaimat
BACKGROUND: Clinicians frequently assume that during arterial puncture for measuring arterial blood gases patients hyperventilate from pain and anxiety. This assumption leads clinicians to falsely interpret a PaCO2 and pH near the upper limit of normal as a chronic respiratory acidosis corrected by an acute respiratory alkalosis. OBJECTIVE: Determine if participants hyperventilate during arterial puncture from pain and anxiety. METHODS: We recruited participants from a pulmonary function laboratory referred for arterial blood gas measurement...
April 6, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28389601/anterior-cerebral-blood-velocity-and-end-tidal-co2-responses-to-exercise-differ-in-children-and-adults
#14
Lindsay A Ellis, Philip N Ainslie, Victoria A Armstrong, Laura Emily Morris, Ryan Gerard Simair, Nathan R Sletten, Christine M Tallon, Ali Mary McManus
Little is known about the response of the cerebrovasculature to acute exercise in children and how these responses might differ with adults. Therefore, we compared changes in middle cerebral artery blood velocity (MCAVmean), partial pressure of end-tidal carbon dioxide (PETCO2), blood pressure and ventilation (VE) in response to incremental exercise between children and adults. Thirteen children [aged 9±1 (SD) y] and 13 sex-matched adults [aged 25±4 y] completed a maximal exercise test during which MCAVmean, PETCO2 and VE were measured continuously...
April 7, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28376542/central-hyperventilation-in-a-patient-with-recurrent-acute-lymphoblastic-leukemia
#15
Anna Krasimirova Karastaneva, Volker Strenger, Daniela Sperl, Wolfgang Schwinger, Herwig Lackner, Christian Urban
No abstract text is available yet for this article.
April 4, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28367294/decrease-in-spectral-entropy-by-low-tidal-volume-ventilation-associated-severe-hypercapnia-a-case-report
#16
Junggun Ann, Sung Mee Jung, Sang-Jin Park
Severe hypercapnia can be predicted by a decrease in cerebral electrical activity. The authors describe a sudden decrease in spectral entropy due to severe hypercapnia-induced respiratory acidosis in a patient with chronic pulmonary obstructive disease during lung resection. After two and a half hours of low tidal volume ventilation in the lateral position, the state entropy suddenly dropped from 45 to 7, without any changes in the effect-site concentration of propofol, end-tidal carbon dioxide (CO2) tension, oxygen saturation, or arterial pressure...
April 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28356297/nitric-oxide-sensitive-guanylyl-cyclase-signaling-affects-co2-dependent-but-not-pressure-dependent-regulation-of-cerebral-blood-flow
#17
Shadi Jahshan, Lior Dayan, Giris Jacob
Cerebrovascular CO2 reactivity is affected by nitric oxide (NO). We tested the hypothesis that sildenafil selectively potentiates NO-cGMP signaling affects CO2 reactivity. Fourteen healthy males (34±2 years) were enrolled in the study. BP, ECG, velocity of cerebral blood flow (CBF, measured by TCD), end tidal CO2 (EtCO2) were assessed at baseline (CO2 ~ 39 mm Hg), during hyperventilation (CO2 ~ 24 mm Hg), hypercapnia (CO2 ~ 46 mm Hg), boluses of phenylephrine (25-200 µg) and during graded head-up tilting (HUT)...
March 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28352057/paroxysmal-kinesigenic-dyskinesia-as-the-presenting-and-only-manifestation-of-multiple-sclerosis-after-eighteen-months-of-follow-up
#18
Marius Baguma, Michel Ossemann
Other than tremor, movement disorders are uncommon in multiple sclerosis. Among these uncommon clinical manifestations, paroxysmal kinesigenic dyskinesia is the most frequently reported. It is characterized by episodic attacks of involuntary movements that are induced by repetitive or sudden movements, startling noise or hyperventilation. The diagnosis is essentially clinical and based on a good observation of the attacks. It is very easy to misdiagnose it. We describe the case of a young female patient who presented paroxysmal kinesigenic dyskinesia as the first and only clinical manifestation of multiple sclerosis, with no recurrence of attacks nor any other neurologic symptom after eighteen months of follow-up...
March 24, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28351539/cardiovascular-autonomic-dysfunction-in-children-and-adolescents-with-rett-syndrome
#19
Ajay Kumar, Ashok Jaryal, Sheffali Gulati, Biswaroop Chakrabarty, Akanksha Singh, K K Deepak, R M Pandey, Neerja Gupta, Savita Sapra, Madhulika Kabra, Rajni Khajuria
BACKGROUND: Autonomic dysfunction is common in children with Rett syndrome. They usually manifest with agitation, persistent screaming, constipation, gastroesophageal reflux, aerophagia, hyperventilation, and breath-holding episodes. Cardiovascular autonomic dysfunction may result in fatal a arrhythmia. Many of these events are mistaken for seizures and treated with antiepileptics. METHODS: The present study was conducted in a tertiary care teaching hospital in north India for more than a six month period...
January 17, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28351484/hypocapnic-hypothesis-of-leigh-disease
#20
Ewa Pronicka
Leigh syndrome (LS) is a neurogenetic disorder of children caused by mutations in at least 75 genes which impair mitochondrial bioenergetics. The changes have typical localization in basal ganglia and brainstem, and typical histological picture of spongiform appearance, vascular proliferation and gliosis. ATP deprivation, free radicals and lactate accumulation are suspected to be the causes. Hypocapnic hypothesis proposed in the paper questions the energy deprivation as the mechanism of LS. We assume that the primary harmful factor is hypocapnia (decrease in pCO2) and respiratory alkalosis (increase in pH) due to hyperventilation, permanent or in response to stress...
April 2017: Medical Hypotheses
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