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Mitral valve prolapse

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https://www.readbyqxmd.com/read/29356304/fast-image-based-mitral-valve-simulation-from-individualized-geometry
#1
Pierre-Frederic Villard, Peter E Hammer, Douglas P Perrin, Pedro J Del Nido, Robert D Howe
BACKGROUND: Common surgical procedures on the mitral valve of the heart include modifications to the chordae tendineae. Such interventions are used when there is extensive leaflet prolapse caused by chordae rupture or elongation. Understanding the role of individual chordae tendineae before operating could be helpful to predict whether the mitral valve will be competent at peak systole. Biomechanical modelling and simulation can achieve this goal. METHODS: We present a method to semi-automatically build a computational model of a mitral valve from micro CT (computed tomography) scans: after manually picking chordae fiducial points, the leaflets are segmented and the boundary conditions as well as the loading conditions are automatically defined...
January 22, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29352010/genetics-of-syndromic-and-non-syndromic-mitral-valve-prolapse
#2
REVIEW
Thierry Le Tourneau, Jean Mérot, Antoine Rimbert, Solena Le Scouarnec, Vincent Probst, Hervé Le Marec, Robert A Levine, Jean-Jacques Schott
Mitral valve prolapse (MVP) is a common condition that affects 2%-3% of the general population. MVP is thought to include syndromic forms such as Marfan syndrome and non-syndromic MVP, which is the most frequent form. Myxomatous degeneration and fibroelastic deficiency (FED) are regarded as two different forms of non-syndromic MVP. While FED is still considered a degenerative disease associated with ageing, frequent familial clustering has been demonstrated for myxomatous MVP. Familial and genetic studies led to the recognition of reduced penetrance and large phenotypic variability, and to the identification of prodromal or atypical forms as a part of the complex spectrum of the disease...
January 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29339711/unusual-combination-of-mitral-valve-prolapse-bicuspid-aortic-valve-and-ventricular-septal-defect-restricted-by-the-tricuspid-septal-leaflet
#3
Umut Kocabaş, Esra Kaya, Cahide Soydaş Çınar
No abstract text is available yet for this article.
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29321434/tricuspid-and-mitral-valve-regurgitation-with-bi-fascicular-block-following-a-horse-kick
#4
Tomoki Kokubun, Masayoshi Oikawa, Yasuhiro Ichijo, Yoshiyuki Matsumoto, Tetsuro Yokokawa, Kazuhiko Nakazato, Yoshiyuki Sato, Shinya Takase, Hiroharu Shinjo, Hitoshi Yokoyama, Hitoshi Suzuki, Shu-Ichi Saitoh, Yasuchika Takeishi
A 40-year-old man was transferred to our hospital following an isolated horse kick injury to the anterior chest wall. The case showed bi-fascicular block, severe tricuspid valve regurgitation due to ruptured chordae tendineae of the anterior leaflet, moderate mitral valve regurgitation due to prolapse of mitral anterior leaflet, and hypokinetic motion of the inferior septal wall. Both tricuspid and mitral insufficiency were completely repaired by a surgical operation. Fortunately, these injuries were not fatal in this case, but the comprehensive assessment of cardiac damage and careful observation are important for managing patients with cardiac injury...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29321211/pathophysiology-of-degenerative-mitral-regurgitation-new-3-dimensional-imaging-insights
#5
Clemence Antoine, Francesca Mantovani, Giovanni Benfari, Sunil V Mankad, Joseph F Maalouf, Hector I Michelena, Maurice Enriquez-Sarano
Despite its high prevalence, little is known about mechanisms of mitral regurgitation in degenerative mitral valve disease apart from the leaflet prolapse itself. Mitral valve is a complex structure, including mitral annulus, mitral leaflets, papillary muscles, chords, and left ventricular walls. All these structures are involved in physiological and pathological functioning of this valvuloventricular complex but up to now were difficult to analyze because of inherent limitations of 2-dimensional imaging. The advent of 3-dimensional echocardiography, computed tomography, and cardiac magnetic resonance imaging overcoming these limitations provides new insights into mechanistic analysis of degenerative mitral regurgitation...
January 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29315310/dysregulation-of-valvular-interstitial-cell-let-7c-mir-17-mir-20a-and-mir-30d-in-naturally-occurring-canine-myxomatous-mitral-valve-disease
#6
Vicky K Yang, Albert K Tai, Terry P Huh, Dawn M Meola, Christine M Juhr, Nicholas A Robinson, Andrew M Hoffman
Canine myxomatous mitral valve disease (MMVD) resembles the early stages of myxomatous pathology seen in human non-syndromic mitral valve prolapse, a common valvular heart disease in the adult human population. Canine MMVD is seen in older subjects, suggesting age-related epigenetic dysregulation leading to derangements in valvular cell populations and matrix synthesis or degradation. We hypothesized that valvular interstitial cells (VICs) undergo disease-relevant changes in miRNA expression. In primary VIC lines from diseased and control valves, miRNA expression was profiled using RT-qPCR and next generation sequencing...
2018: PloS One
https://www.readbyqxmd.com/read/29312750/mitral-valve-prolapse-an-underestimated-cause-of-sudden-cardiac-death-a-current-review-of-the-literature
#7
REVIEW
Michael Spartalis, Eleni Tzatzaki, Eleftherios Spartalis, Antonios Athanasiou, Demetrios Moris, Christos Damaskos, Nikolaos Garmpis, Vassilis Voudris
Mitral valve prolapse (MVP) is a common valve abnormality in general population. Despite the general belief of a benign disorder, several articles since the 1980s report sudden cardiac death (SCD) in MVP patients, with a substantial percentage of asymptomatic young individuals. The problem is to detect those patients at increased risk and implement methods that are suitable to prevent cardiac arrest. This review investigates the correlation between MVP and SCD, the understanding of the pathophysiology, the strategies for detecting those at risk and treatment options...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29309559/causes-of-repair-failure-for-degenerative-mitral-valve-disease-and-reoperation-outcomes
#8
Hidefumi Nishida, Toshihiro Fukui, Hitoshi Kasegawa, Hajime Kin, Masataka Yamazaki, Shuichiro Takanashi
OBJECTIVES: This study aimed to evaluate the causes of initial mitral valve (MV) repair failure, the details of reoperation and the long-term outcomes of mitral valve re-repair (Re-MVP). METHODS: We retrospectively reviewed 86 patients who underwent reoperation after MV repair for MR due to degenerative disease from October 1991 to December 2015. First, we analysed the initial MV repair data, causes of MV repair failure, reoperation data and long-term outcomes including survival...
January 3, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29306705/adverse-impact-of-diabetes-mellitus-on-left-ventricular-remodelling-in-patients-with-chronic-primary-mitral-regurgitation
#9
Laura Ernande, Jonathan Beaudoin, Victoria Piro, Souhila Meziani, Marielle Scherrer-Crosbie
BACKGROUND: Diabetes mellitus (DM) has an impact on left ventricular (LV) geometry and function, and is associated with worsening of pressure-overload LV remodelling; however, its impact on volume-overload LV remodelling is unknown. AIM: The objective of the study was to examine the association between DM and LV remodelling in patients with chronic mitral regurgitation (MR) caused by mitral valve prolapse. METHODS: During a median follow-up of 3...
January 3, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29305187/cardiac-arrest-and-ventricular-arrhythmia-in-adults-with-ebstein-anomaly-and-left-ventricular-non-compaction
#10
Magdalena Kumor, Magdalena Lipczyńska, Elzbieta Katarzyna Biernacka, Anna Klisiewicz, Anna Wójcik, Marek Konka, Katarzyna Kożuch, Piotr Szymański, Piotr Hoffman
BACKGROUND: Ebstein anomaly is a complex, congenital heart defect that is associated with a variety of cardiac abnormalities. Studies found a similar sarcomere gene mutation in patients with Ebstein anomaly (EA) and patients with isolated left ventricular non-compaction (LVNC). AIM: We aimed to show the prevalence of LVNC and its potential relationship with severe cardiac events (VT - ventricular tachycardia, cardiac arrest) in adult patients with EA. METHODS: We conducted a retrospective search of our institutional database from 2010 to 2014 for patients with EA and reviewed patients' medical records (age, sex, clinical presentation, electrocardiographic, echocardiographic, and CMR - cardiac magnetic resonance features)...
January 2, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29291394/serotonin-receptor-2b-signaling-with-interstitial-cell-activation-and-leaflet-remodeling-in-degenerative-mitral-regurgitation
#11
Kathryn H Driesbaugh, Emanuela Branchetti, Juan B Grau, Samuel J Keeney, Kimberly Glass, Mark A Oyama, Nancy Rioux, Salma Ayoub, Michael S Sacks, John Quackenbush, Robert J Levy, Giovanni Ferrari
AIMS: Mitral valve interstitial cells (MVIC) play an important role in the pathogenesis of degenerative mitral regurgitation (MR) due to mitral valve prolapse (MVP). Numerous clinical studies have observed serotonin (5HT) dysregulation in cardiac valvulopathies; however, the impact of 5HT-mediated signaling on MVIC activation and leaflet remodeling in MVP have been investigated to a limited extent. Here we test the hypothesis that 5HT receptors (5HTRs) signaling contributes to MVP pathophysiology...
December 29, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29275594/-comparison-of-early-clinical-effects-of-ablation-with-surgery-treatment-in-patients-with-hypertrophic-cardiomyopathy
#12
Y P Ruan, X W Liu, Y Zhang, J C Han, Y Q Lai, J Lü, Y H He
Objective: To compare the early clinical effect of septal myectomy and percutaneous transluminal septal myocardial ablation (PTMSA) on the left ventricular outflow obstruction and the rate of complication in patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods: A total of 204 patients with HOCM who received septal reduction treatment were recruited. These patients were divided into two groups, surgery group (n=135) (65 patients with modified Morrow procedure, 70 patients with non-Morrow myomectomy) and PTMSA group (n=69)...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29232298/use-of-a-new-expanded-polytetrafluoroethylene-multichordal-mitral-apparatus-mitrapatch-to-repair-complex-mitral-valve-lesions
#13
Surendra K Chawla, Muralidhar Padala, W Randolph Chitwood, Robert W M Frater
OBJECTIVE: We report a new expanded polytetrafluoroethylene multichordal mitral apparatus (MitraPatch) to simplify mitral repairs involving multiple cusps and sought to describe the surgical technique and demonstrate the efficacy of the device. METHODS: MitraPatch was laser cut from a single sheet of expanded polytetrafluoroethylene and mounted on a custom-designed handle. Surgical technique to deploy the apparatus on the native mitral valve was developed in ex vivo porcine hearts...
November 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29225261/a-case-of-isolated-left-atrial-infective-mural-endocarditis
#14
Saki Hosokawa, Hideki Okayama, Go Hiasa, Go Kawamura, Tatsuya Shigematsu, Tatsunori Takahashi, Yoshitaka Kawada, Tadakatsu Yamada, Hiroshi Matsuoka, Yukio Kazatani
A 52-year-old man presented with a fever and malaise. Transthoracic echocardiogram was performed because of a holosystolic murmur, which showed mitral valve prolapse and a regurgitation jet toward the posterior wall of the left atrium. There was no apparent vegetation at any valves. Blood cultures were positive for Streptococcus mitis/oralis. Transesophageal echocardiogram revealed vegetation only at the posterior wall of the left atrium exposed to the mitral regurgitant jet. We diagnosed this condition as infective mural endocarditis...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29224215/deleterious-variants-in-dchs1-are-prevalent-in-sporadic-cases-of-mitral-valve-prolapse
#15
Alisson Clemenceau, Jean-Christophe Bérubé, Paméla Bélanger, Nathalie Gaudreault, Maxime Lamontagne, Oumhani Toubal, Marie-Annick Clavel, Romain Capoulade, Patrick Mathieu, Philippe Pibarot, Yohan Bosse
BACKGROUND: A recent study identified DCHS1 as a causal gene for mitral valve prolapse. The goal of this study is to investigate the presence and frequency of known and novel variants in this gene in 100 asymptomatic patients with moderate to severe organic mitral regurgitation. METHODS: DNA sequencing assays were developed for two previously identified functional missense variants, namely p.R2330C and p.R2513H, and all 21 exons of DCHS1. Pathogenicity of variants was evaluated in silico...
December 10, 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29220425/a-leaflet-plication-clip-is-an-effective-surgical-template-for-mitral-valve-foldoplasty
#16
Isaac Wamala, Mossab Saeed, Sunil J Ghelani, Kimberlee Gauvreau, Peter E Hammer, Nikolay V Vasilyev, Pedro J Del Nido
OBJECTIVES: During mitral valve repair using the foldoplasty technique, correct judgement of the necessary dimensions and orientation of the leaflet fold is a critical but challenging step that can affect the chances of successful repair. In this study, we investigated whether a leaflet plication clip can be used to guide suture foldoplasty for posterior leaflet prolapse of the mitral valve. METHODS: Complete posterior leaflet prolapse was created in both in vivo and ex vivo pig hearts by severing the chordae supporting the middle scallop...
December 6, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29186494/mitral-valve-repair-in-barlow-s-disease-with-bileaflet-prolapse-the-effect-of-annular-stabilization-on-functional-mitral-valve-leaflet-prolapse
#17
Anton Tomšic, Yasmine L Hiemstra, Daniella D Bissessar, Thomas J van Brakel, Michel I M Versteegh, Nina Ajmone Marsan, Robert J M Klautz, Meindert Palmen
OBJECTIVES: Barlow's disease is the most severe form of degenerative mitral valve disease, commonly characterized by bileaflet prolapse. Abnormal mitral annular dynamics is typically present and results in functional prolapse of the mitral leaflets that may be addressed with annular stabilization alone. METHODS: Between January 2001 and December 2015, 128 patients with Barlow's disease and bileaflet prolapse underwent valve repair. This included anterior mitral valve leaflet (AMVL) repair in 70 patients, whereas 58 patients were identified as having functional prolapse and underwent no specific AMVL repair...
November 27, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29149258/edge-to-edge-repair-for-mitral-regurgitation-associated-with-isolated-double-orifice-mitral-valve
#18
Takeshi Oda, Takanori Kono, Keiichi Akaiwa, Katsuhiko Nakamura
We report the case of a patient with severe mitral regurgitation who was diagnosed with double-orifice mitral valve by preoperative transthoracic and transoesophageal echocardiography. During surgery, it was revealed that the mitral valve was divided into 2 orifices, anterolateral and posteromedial, by a fibrous bridging tissue that was supported by the chordae tendineae originating from an accessory middle papillary muscle. The posterior scallop of the anterolateral orifice was prolapsed due to chordal elongation...
November 15, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29147460/corrigendum-to-identification-of-patients-affected-by-mitral-valve-prolapse-with-severe-regurgitation-a-multivariable-regression-model
#19
Paola Songia, Benedetta Porro, Mattia Chiesa, Veronika Myasoedova, Francesco Alamanni, Elena Tremoli, Paolo Poggio
[This corrects the article DOI: 10.1155/2017/6838921.].
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29122631/mitral-valve-prolapse-multimodality-imaging-and-genetic-insights
#20
REVIEW
Purvi Parwani, Jean-Francois Avierinos, Robert A Levine, Francesca N Delling
Mitral valve prolapse (MVP) is a common heritable valvulopathy affecting approximately 2.4% of the population. It is the most important cause of primary mitral regurgitation (MR) requiring surgery. MVP is characterized by fibromyxomatous changes and displacement of one or both mitral leaflets into the left atrium. Echocardiography represents the primary diagnostic modality for assessment of MVP. Accurate quantitation of ventricular volumes and function for surgical planning in asymptomatic severe MR can be provided with both echocardiography and cardiac magnetic resonance...
November 6, 2017: Progress in Cardiovascular Diseases
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