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https://www.readbyqxmd.com/read/29036505/increased-mortality-in-haemodialysis-patients-administered-high-doses-of-erythropoiesis-stimulating-agents-a-propensity-score-matched-analysis
#1
Rafael Pérez-García, Javier Varas, Alejandro Cives, Alejandro Martín-Malo, Pedro Aljama, Rosa Ramos, Julio Pascual, Stefano Stuard, Bernard Canaud, José Ignacio Merello
Background: Erythropoiesis-stimulating agents (ESAs) are widely used to treat anaemia in patients with chronic kidney disease. The issue of ESA safety has been raised in multiple studies, with correlates derived for elevated cancer incidence and mortality. Whether these associations are related to ESA dose or the typology of the patient remains obscure. Methods: A multicentre, observational retrospective propensity score-matched study was designed to analyse the effects of weekly ESA dose in 1679 incident haemodialysis (HD) patients...
September 28, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29034851/nitrosopumilus-maritimus-gen-nov-sp-nov-nitrosopumilus-cobalaminigenes-sp-nov-nitrosopumilus-oxyclinae-sp-nov-and-nitrosopumilus-ureiphilus-sp-nov-four-marine-ammonia-oxidizing-archaea-of-the-phylum-thaumarchaeota
#2
Wei Qin, Katherine R Heal, Rasika Ramdasi, Julia N Kobelt, Willm Martens-Habbena, Anthony D Bertagnolli, Shady A Amin, Christopher B Walker, Hidetoshi Urakawa, Martin Könneke, Allan H Devol, James W Moffett, E Virginia Armbrust, Grant J Jensen, Anitra E Ingalls, David A Stahl
Four mesophilic, neutrophilic, and aerobic marine ammonia-oxidizing archaea, designated strains SCM1(T), HCA1(T), HCE1(T) and PS0(T), were isolated from a tropical marine fish tank, dimly lit deep coastal waters, the lower euphotic zone of coastal waters, and near-surface sediment in the Puget Sound estuary, respectively. Cells are straight or slightly curved small rods, 0.15-0.26 µm in diameter and 0.50-1.59 µm in length. Motility was not observed, although strain PS0(T) possesses genes associated with archaeal flagella and chemotaxis, suggesting it may be motile under some conditions...
October 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29023234/using-geographical-convergence-of-obesity-cardiovascular-disease-and-type-2-diabetes-at-the-neighborhood-level-to-inform-policy-and-practice
#3
Kayla Smurthwaite, Nasser Bagheri
INTRODUCTION: Chronic diseases are increasing across the world. Examination of local geographic variation in chronic disease patterns can enable policy makers to identify inequalities in health outcomes and tailor effective interventions to communities at higher risk. Our study aimed to determine the geographic variation of obesity, cardiovascular disease (CVD), and type 2 diabetes, using general practice clinical data. Further objectives included identifying regions of significantly high and low clusters of these conditions and assessing their association with sociodemographic characteristics...
October 12, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29020186/rabies-postexposure-prophylaxis-pep-noncompletion-after-dog-bites-estimating-the-unseen-to-meet-the-needs-of-the-underserved
#4
Arnaud Tarantola, Sophie Blanchi, Julien Cappelle, Sowath Ly, Malen Chan, Sotheary In, Yiksing Peng, Chanthy Hing, Chun Navy Taing, Sovann Ly, Hervé Bourhy, Philippe Buchy, Philippe Dussart, Jean-Yves Mary
Post exposure prophylaxis prevents human rabies and is accessible in Cambodia principally in Phnom Penh, the capital. Timely, affordable access to post-exposure prophylaxis is a challenge for the mainly rural population. We aimed to identify districts independently associated with post-exposure prophylaxis (PEP) noncompletion to position frontline vaccination centers. We analyzed the 2009-2013 database at the rabies prevention center of the Institut Pasteur du Cambodge, Phnom Penh. Logistic regressions identified non-geographic determinants of PEP noncompletion and districts after adjustment for these determinants...
August 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28992120/relationships-between-iron-dose-hospitalizations-and-mortality-in-incident-haemodialysis-patients-a-propensity-score-matched-approach
#5
Javier Varas, Rosa Ramos, Pedro Aljama, Rafael Pérez-García, Francesc Moreso, Miguel Pinedo, José Ignacio Merello, Stefano Stuard, Bernard Canaud, Alejandro Martín-Malo
Background: Intravenous iron management is common in the haemodialysis population. However, the safest dosing strategy remains uncertain, in terms of the risk of hospitalization and mortality. We aimed to determine the effects of cumulative monthly iron doses on mortality and hospitalization. Methods: This multicentre observational retrospective propensity-matched score study included 1679 incident haemodialysis patients. We measured baseline demographic variables, haemodialysis clinical parameters and laboratory analytical values...
July 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28981339/preclinical-modelling-of-militarily-relevant-traumatic-brain-injuries-challenges-and-recommendations-for-future-directions
#6
Ibolja Cernak, Donald G Stein, Gregory A Elder, Stephn Ahlers, Kenneth Curley, Ralph G DePalma, John Duda, Milos Ikonomovic, Grant L Iverson, Firas Kobeissy, Vassilis E Koliatsos, Michael J Leggieri, Anthony M Pacifico, Douglas H Smith, Raymond Swanson, Floyd J Thompson, Frank C Tortella
As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28979545/intermediate-level-training-a-paradigm-requiring-reflective-competence
#7
Andrew Lane, Sam R Orde
No abstract text is available yet for this article.
February 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/28978755/mammal-decline-linked-to-invasive-burmese-python-shifts-host-use-of-vector-mosquito-towards-reservoir-hosts-of-a-zoonotic-disease
#8
Isaiah J Hoyer, Erik M Blosser, Carolina Acevedo, Anna Carels Thompson, Lawrence E Reeves, Nathan D Burkett-Cadena
Invasive apex predators have profound impacts on natural communities, yet the consequences of these impacts on the transmission of zoonotic pathogens are unexplored. Collapse of large- and medium-sized mammal populations in the Florida Everglades has been linked to the invasive Burmese python, Python bivittatus Kuhl. We used historic and current data to investigate potential impacts of these community effects on contact between the reservoir hosts (certain rodents) and vectors of Everglades virus, a zoonotic mosquito-borne pathogen that circulates in southern Florida...
October 2017: Biology Letters
https://www.readbyqxmd.com/read/28953979/the-transcription-factor-chop-an-effector-of-the-integrated-stress-response-is-required-for-host-sensitivity-to-the-fungal-intracellular-pathogen-histoplasma-capsulatum
#9
Bevin C English, Nancy Van Prooyen, Tiit Örd, Tõnis Örd, Anita Sil
The ability of intracellular pathogens to manipulate host-cell viability is critical to successful infection. Some pathogens promote host-cell survival to protect their replicative niche, whereas others trigger host-cell death to facilitate release and dissemination of the pathogen after intracellular replication has occurred. We previously showed that the intracellular fungal pathogen Histoplasma capsulatum (Hc) uses the secreted protein Cbp1 to actively induce apoptosis in macrophages; interestingly, cbp1 mutant strains are unable to kill macrophages and display severely reduced virulence in the mouse model of Hc infection...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28939808/novel-pathogenic-mutations-in-c1qtnf5-support-a-dominant-negative-disease-mechanism-in-late-onset-retinal-degeneration
#10
Chloe M Stanton, Shyamanga Borooah, Camilla Drake, Joseph A Marsh, Susan Campbell, Alan Lennon, Dinesh C Soares, Neeru A Vallabh, Jayashree Sahni, Artur V Cideciyan, Baljean Dhillon, Veronique Vitart, Samuel G Jacobson, Alan F Wright, Caroline Hayward
Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual loss. L-ORD shows striking phenotypic similarities to age-related macular degeneration (AMD), a common and genetically complex disorder, which can lead to misdiagnosis in the early stages. To date, a single missense mutation (S163R) in the C1QTNF5 gene, encoding C1q And Tumor Necrosis Factor Related Protein 5 (C1QTNF5) has been shown to cause L-ORD in a subset of affected families...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926691/cobalt-porphyrin-thiazyl-radical-coordination-polymers-toward-metal-organic-electronics
#11
Delia A Haynes, Laura J van Laeren, Orde Q Munro
Herein we delineate an unusual one-dimensional coordination polymer (CP), 3, prepared from S = 1/2 Co(TPP), 1 (TPP = 5,10,15,20-tetraphenylporphyrin dianion), and S = 1/2 4-(4'-pyridyl)-1,2,3,5-dithiadiazolyl (py-DTDA) radical, 2. The atypically long S-S distance for CP 3 (2.12 Å) reflects fractional electron transfer from the formally Co(II) ion into the antibonding π-SOMO of the metal-bound py-DTDA bridging ligand. The bonding in solid CP 3 involves noninteger redox states in a resonance hybrid repeat unit best formulated as [Co(TPP)](0...
October 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28901768/importance-and-difficulties-in-the-use-of-chiroptical-methods-to-assign-the-absolute-configuration-of-natural-products-the-case-of-phytotoxic-pyrones-and-furanones-produced-by-diplodia-corticola
#12
Giuseppe Mazzeo, Alessio Cimmino, Marco Masi, Giovanna Longhi, Lucia Maddau, Maurizio Memo, Antonio Evidente, Sergio Abbate
α-Pyrones and furanones are metabolites produced by Diplodia corticola, a pathogen of cork oak. Previously, the absolute configuration (AC) of diplopyrone was defined by chiroptical methods and Mosher's method. Using X-ray and chiroptical methods, the AC of sapinofuranone C was assigned, while that of the (4S,5S)-enantiomer of sapinofuranone B was established by enantioselective total synthesis. Diplofuranone A and diplobifuranylones A-C ACs are still unassigned. Here electronic and vibrational circular dichroism (ECD and VCD) and optical rotatory dispersion (ORD) spectra are reported and compared with density functional theory computations...
September 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28878692/optimization-of-an-in-silico-cardiac-cell-model-for-proarrhythmia-risk-assessment
#13
Sara Dutta, Kelly C Chang, Kylie A Beattie, Jiansong Sheng, Phu N Tran, Wendy W Wu, Min Wu, David G Strauss, Thomas Colatsky, Zhihua Li
Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many drugs from the market and is therefore of major concern to global regulatory agencies and the pharmaceutical industry. The Comprehensive in vitro Proarrhythmia Assay (CiPA) was proposed to improve prediction of TdP risk, using in silico models and in vitro multi-channel pharmacology data as integral parts of this initiative. Previously, we reported that combining dynamic interactions between drugs and the rapid delayed rectifier potassium current (IKr) with multi-channel pharmacology is important for TdP risk classification, and we modified the original O'Hara Rudy ventricular cell mathematical model to include a Markov model of IKr to represent dynamic drug-IKr interactions (IKr-dynamic ORd model)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28864988/long-term-effects-of-the-periconception-period-on-embryo-epigenetic-profile-and-phenotype-the-role-of-stress-and-how-this-effect-is-mediated
#14
James Ord, Alireza Fazeli, Penelope J Watt
Stress represents an unavoidable aspect of human life, and pathologies associated with dysregulation of stress mechanisms - particularly psychiatric disorders - represent a significant global health problem. While it has long been observed that levels of stress experienced in the periconception period may greatly affect the offspring's risk of psychiatric disorders, the mechanisms underlying these associations are not yet comprehensively understood. In order to address this question, this chapter will take a 'top-down' approach, by first defining stress and associated concepts, before exploring the mechanistic basis of the stress response in the form of the hypothalamic-pituitary-adrenal (HPA) axis, and how dysregulation of the HPA axis can impede our mental and physical health, primarily via imbalances in glucocorticoids (GCs) and their corresponding receptors (GRs) in the brain...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28859279/the-superovulated-environment-independent-of-embryo-vitrification-results-in-low-birthweight-in-a-mouse-model
#15
Rachel Weinerman, Teri Ord, Marisa S Bartolomei, Christos Coutifaris, Monica Mainigi
Epidemiological studies suggest that babies born following in vitro fertilization (IVF) and fresh embryo transfer are of lower birthweight than babies born following frozen embryo transfer, although the mechanism responsible for this phenotype is not known. We developed a novel mouse model that isolates the independent effects of embryo freezing and the superovulated environment, which cannot be performed in humans. We transferred blastocysts that had been vitrified and warmed, mixed with with fresh blastocysts, into individual pseudopregnant recipients produced by either natural mating or mating following injection with equine chorionic gonadotropin and human chorionic gonadotropin and hCG (superovulation)...
July 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28857472/dual-ph-magnetic-field-controlled-drug-delivery-systems-based-on-fe3-o4-sio2-incorporated-salecan-graft-copolymer-composite-hydrogels
#16
Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Jianfa Zhang, Wei Dong
Salecan is a water-soluble extracellular β-glucan and has excellent physicochemical and biological properties for hydrogel preparation. In this study, a new pH/magnetic field dual-responsive hydrogel was prepared by the graft copolymerization of salecan with 4-pentenoic acid (PA) and N-hydroxyethylacrylamide (HEAA) in the presence of Fe3 O4 @SiO2 nanoparticles for doxorubicin hydrochloride (DOX) release. Integration of Fe3 O4 @SiO2 nanoparticles in salecan-g-poly(PA-co-HEAA) copolymers afforded magnetic sensitivity to the original material...
August 31, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28852767/european-society-of-paediatric-radiology-abdominal-imaging-task-force-recommendations-in-paediatric-uroradiology-part-ix-imaging-in-anorectal-and-cloacal-malformation-imaging-in-childhood-ovarian-torsion-and-efforts-in-standardising-paediatric-uroradiology
#17
REVIEW
Michael Riccabona, Maria-Luisa Lobo, Lil-Sofie Ording-Muller, A Thomas Augdal, E Fred Avni, Johan Blickman, Constanza Bruno, Beatrice Damasio, Kassa Darge, Akaterina Ntoulia, Frederica Papadopoulou, Pierre-Hugues Vivier
At the occasion of the European Society of Paediatric Radiology (ESPR) annual meeting 2015 in Graz, Austria, the newly termed ESPR abdominal (gastrointestinal and genitourinary) imaging task force set out to complete the suggestions for paediatric urogenital imaging and procedural recommendations. Some of the last missing topics were addressed and proposals on imaging of children with anorectal and cloacal malformations and suspected ovarian torsion were issued after intense discussions and a consensus finding process that considered all evidence...
September 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28833487/absolute-configuration-of-an-axially-chiral-sulfonate-determined-from-its-optical-rotatory-dispersion-electronic-circular-dichroism-and-vibrational-circular-dichroism-spectra
#18
Cody L Covington, Vijay Raghavan, Jonathan P Smuts, Daniel W Armstrong, Prasad L Polavarapu
The absolute configuration (AC) of an axially chiral sulfonate (aCSO), 3,5-dimethyl-2-(naphthalen-1-yl)-6-(naphthalen-1-yl)benzenesulfonate (labeled as aCSO5), was investigated using optical rotatory dispersion (ORD), electronic circular dichroism (ECD), and vibrational circular dichroism (VCD) spectroscopies. All three methods led to the same conclusion and the AC of aCSO5 is reliably determined to be (-)-(aR, aR), or conversely (+)-(aS, aS).
August 18, 2017: Chirality
https://www.readbyqxmd.com/read/28830521/addressing-geographic-access-barriers-to-emergency-care-services-a-national-ecologic-study-of-hospitals-in-brazil
#19
Thiago Augusto Hernandes Rocha, Núbia Cristina da Silva, Pedro Vasconcelos Amaral, Allan Claudius Queiroz Barbosa, João Victor Muniz Rocha, Viviane Alvares, Dante Grapiuna de Almeida, Elaine Thumé, Erika Bárbara Abreu Fonseca Thomaz, Rejane Christine de Sousa Queiroz, Marta Rovery de Souza, Adriana Lein, Daniel Paulino Lopes, Catherine A Staton, João Ricardo Nickenig Vissoci, Luiz Augusto Facchini
BACKGROUND: Unequal distribution of emergency care services is a critical barrier to be overcome to assure access to emergency and surgical care. Considering this context it was objective of the present work analyze geographic access barriers to emergency care services in Brazil. A secondary aim of the study is to define possible roles to be assumed by small hospitals in the Brazilian healthcare network to overcome geographic access challenges. METHODS: The present work can be classified as a cross-sectional ecological study...
August 22, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28821371/at-the-intersection-of-place-race-and-health-in-brazil-residential-segregation-and-cardio-metabolic-risk-factors-in-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#20
Sharrelle Barber, Ana V Diez Roux, Letícia Cardoso, Simone Santos, Veronica Toste, Sherman James, Sandhi Barreto, Maria Schmidt, Luana Giatti, Dora Chor
Residential segregation is the spatial manifestation of entrenched socioeconomic and racial inequities and is considered a fundamental cause of racial inequalities in health. Despite the well-documented racialized spatial inequalities that exist in urban areas throughout Brazil, few empirical investigations have examined the link between residential segregation and health and considered its implications for racial health inequalities in this setting. In the present study, we used data from the Brazilian Longitudinal Study of Adult Health (2008-2010) to examine the association between economic residential segregation and two major cardio-metabolic risk factors-hypertension and diabetes...
May 27, 2017: Social Science & Medicine
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