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https://www.readbyqxmd.com/read/29426137/spatial-pattern-and-variations-in-the-prevalence-of-congenital-heart-disease-in-children-aged-4-18%C3%A2-years-in-the-qinghai-tibetan-plateau
#1
Li-Guang Ma, Qiu-Hong Chen, Yuan-Yuan Wang, Jing Wang, Zhou-Peng Ren, Zong-Fu Cao, Yan-Rong Cao, Xu Ma, Bin-Bin Wang
PURPOSE: This study aimed to investigate the spatial distribution pattern of the prevalence of congenital heart disease (CHD) in children in Qinghai-Tibetan Plateau (QTP), a high-altitude region in China. METHODS: Epidemiological data from a survey on the prevalence of CHD in Qinghai Province including 288,066 children (4-18 years) were used in this study. The prevalence and distribution pattern of CHD was determined by sex, CHD subtype, and nationality and altitude...
January 29, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29422548/africa-wide-evaluation-of-host-biomarkers-in-quantiferon-supernatants-for-the-diagnosis-of-pulmonary-tuberculosis
#2
Novel N Chegou, Jayne S Sutherland, Anna-Ritah Namuganga, Paul Lam Corstjens, Annemieke Geluk, Gebremedhin Gebremichael, Joseph Mendy, Stephanus Malherbe, Kim Stanley, Gian D van der Spuy, Magdalena Kriel, Andre G Loxton, Belinda Kriel, Felanji Simukonda, Yonas Bekele, Jacob A Sheehama, Josefina Nelongo, Marieta van der Vyver, Atsbeha Gebrexabher, Habteyes Hailu, Maria M Esterhuyse, Ida Rosenkrands, Claus Aagard, Martin Kidd, Desta Kassa, Adane Mihret, Rawleigh Howe, Jacqueline M Cliff, Amelia C Crampin, Harriet Mayanja-Kizza, Stefan H E Kaufmann, Hazel M Dockrell, Tom H M Ottenhoff, Gerhard Walzl
We investigated host-derived biomarkers that were previously identified in QuantiFERON supernatants, in a large pan-African study. We recruited individuals presenting with symptoms of pulmonary TB at seven peripheral healthcare facilities in six African countries, prior to assessment for TB disease. We then evaluated the concentrations of 12 biomarkers in stored QuantiFERON supernatants using the Luminex platform. Based on laboratory, clinical and radiological findings and a pre-established algorithm, participants were classified as TB disease or other respiratory diseases(ORD)...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29413710/comparing-the-geographic-distribution-and-location-characteristics-of-hiv-seropositive-and-hiv-seronegative-individuals-with-a-diagnosis-of-cancer-living-in-the-southeast-us
#3
Benjamin D Hallowell, Sara W Robb, Kristina W Kintziger
As HIV-seropositive individuals live longer, they are more likely to acquire conditions seen in the general population. Excluding AIDS-defining malignancies, HIV-seropositive individuals are more likely to develop cancer than individuals in the general population. In order to better inform future screening and prevention efforts in this population, we compared the geographic distribution and location characteristics of HIV-seropositive and HIV-seronegative cancer cases in South Carolina (SC). To do this we obtained linked HIV and cancer data from the SC enhanced HIV/AIDS Reporting System and Central Cancer Registry...
February 2018: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/29405101/island-wide-surveillance-of-gastrointestinal-protozoan-infections-on-fiji-by-expanding-lymphatic-filariasis-transmission-assessment-surveys-as-an-access-platform
#4
Sung Hye Kim, Milika Rinamalo, Meleresita Rainima-Qaniuci, Nemani Talemaitoga, Mike Kama, Eric Rafai, John H Lowry, Min-Ho Choi, Sung-Tae Hong, Jaco J Verweij, Louise Kelly-Hope, John Russell Stothard
As part of lymphatic filariasis (LF) transmission assessment surveys (TAS) on Fiji, an island-wide assessment of gastrointestinal protozoan infection was performed through concomitant stool sample collections to investigate the distribution of the protozoan infection. All grade 1 and 2 students of 69 schools in the two main islands were targeted in two phases (one in the Western Division and the other in the Central and Northern, except Taveuni sub-Division of Northern), where fecal samples of 1,800 students were available for coproscopy using the formalin-ether-acetate concentration...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29400355/epa-leadership-on-science-innovation-and-decision-support-tools-for-addressing-current-and-future-challenges
#5
Alan D Hecht, Aaron Ferster, Kevin Summers
When the U.S. Environmental Protection Agency (EPA) was established nearly 50 years ago, the nation faced serious threats to its air, land, and water, which in turn impacted human health. These threats were effectively addressed by the creation of EPA (in 1970) and many subsequent landmark environmental legislations which in turn significantly reduced threats to the Nation's environment and public health. A key element of historic legislation is research aimed at dealing with current and future problems. Today we face national and global challenges that go beyond classic media-specific (air, land, water) environmental legislation and require an integrated paradigm of action and engagement based on (1) innovation based on science and technology, (2) stakeholder engagement and collaboration, and (3) public education and support...
October 16, 2017: Jacobs J Environ Sci
https://www.readbyqxmd.com/read/29378327/trib3-limits-fgf21-induction-during-in-vitro-and-in-vivo-nutrient-deficiencies-by-inhibiting-c-ebp-atf-response-elements-in-the-fgf21-promoter
#6
Tiit Örd, Daima Örd, Tõnis Örd
Mammals must be able to endure periods of limited food availability, and the liver plays a central role in the adaptation to nutritional stresses. TRIB3 (Tribbles homolog 3) is a cellular stress-inducible gene with a liver-centric expression pattern and it has been implicated in stress response regulation and metabolic control. In the current article, we study the involvement of TRIB3 in responses to nutrient deficiencies, including fasting for up to 48 h in mice. We show that hepatic expression of Trib3 is increased after 48 h of fasting and mice with a targeted deletion of the Trib3 gene present elevated hepatic triglyceride content and liver weight at 48 h, along with an upregulation of lipid utilization genes in the liver...
January 26, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29374211/low-altitude-solar-magnetic-reconnection-type-iii-solar-radio-bursts-and-x-ray-emissions
#7
I H Cairns, V V Lobzin, A Donea, S J Tingay, P I McCauley, D Oberoi, R T Duffin, M J Reiner, N Hurley-Walker, N A Kudryavtseva, D B Melrose, J C Harding, G Bernardi, J D Bowman, R J Cappallo, B E Corey, A Deshpande, D Emrich, R Goeke, B J Hazelton, M Johnston-Hollitt, D L Kaplan, J C Kasper, E Kratzenberg, C J Lonsdale, M J Lynch, S R McWhirter, D A Mitchell, M F Morales, E Morgan, S M Ord, T Prabu, A Roshi, N Udaya Shankar, K S Srivani, R Subrahmanyan, R B Wayth, M Waterson, R L Webster, A R Whitney, A Williams, C L Williams
Type III solar radio bursts are the Sun's most intense and frequent nonthermal radio emissions. They involve two critical problems in astrophysics, plasma physics, and space physics: how collective processes produce nonthermal radiation and how magnetic reconnection occurs and changes magnetic energy into kinetic energy. Here magnetic reconnection events are identified definitively in Solar Dynamics Observatory UV-EUV data, with strong upward and downward pairs of jets, current sheets, and cusp-like geometries on top of time-varying magnetic loops, and strong outflows along pairs of open magnetic field lines...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29368956/chemical-constituents-and-biological-activities-of-viburnum-macrocephalum-f-keteleeri
#8
Jian-Hua Shao, Jia Chen, Xiao-Qing Xu, Chun-Chao Zhao, Zi-Ling Dong, Wen-Yan Liu, Jie Shen
Three new compounds (1-3) and seven known compounds (4-10) have been isolated from the ethanolic extract of Viburnum macrocephalum f. keteleeri using bioactivity-guided fractionation and identified as methyl (2-α-L-rhamnopyranosyloxy)acetate (1), methyl (2R-3-α-L-rhamnopyranosyloxy)glycerate (2), methyl (3R-4-α-L-rhamnopyranosyloxy-3-hydroxy)butanoate (3), bridelionoside B (4), (6S,7E,9R)-roseoside (5), linarionoside A (6), 3,7,11-trimethyl-1,6-dodecadien-3,10,11-triol (7), (+)-8-hydroxylinalool (8), β-sitosterol (9) and daucosterol (10)...
January 25, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29367151/a-new-classification-of-the-dictyostelids
#9
Sanea Sheikh, Mats Thulin, James C Cavender, Ricardo Escalante, Shin-Ichi Kawakami, Carlos Lado, John C Landolt, Vidyanand Nanjundiah, David C Queller, Joan E Strassmann, Frederick W Spiegel, Steven L Stephenson, Eduardo M Vadell, Sandra L Baldauf
Traditional morphology-based taxonomy of dictyostelids is rejected by molecular phylogeny. A new classification is presented based on monophyletic entities with consistent and strong molecular phylogenetic support and that are, as far as possible, morphologically recognizable. All newly named clades are diagnosed with small subunit ribosomal RNA (18S rRNA) sequence signatures plus morphological synapomorphies where possible. The two major molecular clades are given the rank of order, as Acytosteliales ord. nov...
November 24, 2017: Protist
https://www.readbyqxmd.com/read/29363033/identification-of-the-driving-factors-influences-on-regional-energy-related-carbon-emissions-in-china-based-on-geographical-detector-method
#10
Xinlin Zhang, Yuan Zhao
To investigate the influences of different factors on spatial heterogeneity of regional carbon emissions, we firstly studied the spatial-temporal dynamics of regional energy-related carbon emissions using global Moran's I and Getis-Ord Gi and applied geographical detector model to explain the spatial heterogeneity of regional carbon emissions. Some conclusions were drawn. Regional carbon emissions showed significant global and local spatial autocorrelation. The carbon emissions were greater in eastern and northern regions than in western and southern regions...
January 23, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29358326/oxysterol-binding-protein-related-protein-5-orp5-promotes-cell-proliferation-by-activation-of-mtorc1-signaling
#11
Ximing Du, Armella Zadoorian, Ivan E Lukmantara, Yanfei Qi, Andrew J Brown, Hongyuan Yang
Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a large family of proteins that mainly function in lipid transport and sensing. ORP5 is an endoplasmic reticulum (ER)-anchored protein implicated in lipid transfer at the contact sites between the ER and other membranes. Recent studies indicate that ORP5 is also involved in cancer cell invasion and tumor progression. However, the molecular mechanism underlying ORP5's involvement in cancer is unclear. Here, we report that ORP5 promotes cell proliferation and motility of HeLa cells, an effect that depends on its functional OSBP-related domain (ORD)...
January 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29356338/in-utero-exposure-to-the-1918-pandemic-influenza-in-denmark-and-risk-of-dementia
#12
Noelle M Cocoros, Anne Gulbech Ording, Erzsébet Horváth-Puhó, Victor W Henderson, Henrik Toft Sørensen
BACKGROUND: Substantial but inconclusive evidence suggests in utero exposure to influenza infection may be linked with Alzheimer's disease. OBJECTIVES: We examined whether individuals exposed in utero to the 1918 influenza pandemic are at increased risk of dementia. PATIENTS/METHODS: In this cohort study, surveillance data were used to identify months when influenza activity was at its peak during the pandemic. Using birth dates, exposed and unexposed individuals were identified based on whether they were in utero during ≥1 of the peak months...
January 22, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29343692/symmetric-decomposition-of-asymmetric-games
#13
Karl Tuyls, Julien Pérolat, Marc Lanctot, Georg Ostrovski, Rahul Savani, Joel Z Leibo, Toby Ord, Thore Graepel, Shane Legg
We introduce new theoretical insights into two-population asymmetric games allowing for an elegant symmetric decomposition into two single population symmetric games. Specifically, we show how an asymmetric bimatrix game (A,B) can be decomposed into its symmetric counterparts by envisioning and investigating the payoff tables (A and B) that constitute the asymmetric game, as two independent, single population, symmetric games. We reveal several surprising formal relationships between an asymmetric two-population game and its symmetric single population counterparts, which facilitate a convenient analysis of the original asymmetric game due to the dimensionality reduction of the decomposition...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29332166/imaging-in-juvenile-idiopathic-arthritis-international-initiatives-and-ongoing-work
#14
REVIEW
Charlotte M Nusman, Laura Tanturri de Horatio, Robert Hemke, E Charlotte van Gulik, Lil-Sofie Ording Müller, Clara Malattia, Derk Avenarius, Paolo Toma, Johannes Roth, Nikolay Tzaribachev, Silvia Magni-Manzoni, Mario Maas, Andrea S Doria, Karen Rosendahl
Imaging is increasingly being integrated into clinical practice to improve diagnosis, disease control and outcome in children with juvenile idiopathic arthritis. Over the last decades several international groups have been launched to standardize and validate different imaging techniques. To enhance transparency and facilitate collaboration, we present an overview of ongoing initiatives.
January 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29303847/obesity-in-the-workplace-impact-outcomes-and-recommendations
#15
Charles M Yarborough, Stacy Brethauer, Wayne N Burton, Raymond J Fabius, Pamela Hymel, Shanu Kothari, Robert F Kushner, John Magaña Morton, Kathryn Mueller, Nicolaas P Pronk, Mitchell S Roslin, David B Sarwer, Brian Svazas, Jeffrey S Harris, Garrett I Ash, Jamie T Stark, Marianne Dreger, Julie Ording
OBJECTIVE: To conduct a comprehensive literature review to develop recommendations for managing obesity among workers to improve health outcomes and to explore the impact of obesity on health costs to determine whether a case can be made for surgical interventions and insurance coverage. METHODS: We searched PubMed from 2011 to 2016, and CINAHL, Scopus, and Cochrane Registry of Clinical Trials for interventions addressing obesity in the workplace. RESULTS: A total of 1419 articles were screened, resulting in 275 articles being included...
January 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29301546/spatial-and-temporal-patterns-of-dengue-infections-in-timor-leste-2005-2013
#16
Kinley Wangdi, Archie C A Clements, Tai Du, Susana Vaz Nery
BACKGROUND: Dengue remains an important public health problem in Timor-Leste, with several major epidemics occurring over the last 10 years. The aim of this study was to identify dengue clusters at high geographical resolution and to determine the association between local environmental characteristics and the distribution and transmission of the disease. METHODS: Notifications of dengue cases that occurred from January 2005 to December 2013 were obtained from the Ministry of Health, Timor-Leste...
January 4, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29288256/integrating-tools-for-non-targeted-analysis-research-and-chemical-safety-evaluations-at-the-us-epa
#17
REVIEW
Jon R Sobus, John F Wambaugh, Kristin K Isaacs, Antony J Williams, Andrew D McEachran, Ann M Richard, Christopher M Grulke, Elin M Ulrich, Julia E Rager, Mark J Strynar, Seth R Newton
Tens-of-thousands of chemicals are registered in the U.S. for use in countless processes and products. Recent evidence suggests that many of these chemicals are measureable in environmental and/or biological systems, indicating the potential for widespread exposures. Traditional public health research tools, including in vivo studies and targeted analytical chemistry methods, have been unable to meet the needs of screening programs designed to evaluate chemical safety. As such, new tools have been developed to enable rapid assessment of potentially harmful chemical exposures and their attendant biological responses...
December 29, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29281919/terretonin-m-a-new-meroterpenoid-from-the-thermophilic-aspergillus-terreus-tm8-and-revision-of-the-absolute-configuration-of-penisimplicins
#18
Mohamed Shaaban, Mohammad Magdy El-Metwally, Ahmed Adel Abdel-Razek, Hartmut Laatsch
Terretonin M (1), a new highly oxygenated tetracyclic meroterpenoid, was isolated from the thermophilic fungus Aspergillus terreus TM8 together with 10 known metabolites: terrelumamide A, asterrelenin, 7-prenyl-indolyl-3-carbaldehyde, (3β,5α,6β)-3,5,6-trihydroxy-ergosta-7,22-diene, sitostenone, linoleic acid, ergosterol, uracil, p-hydroxy-benzoic acid, and indole-3-carboxylic acid. The chemical structure of the new compound was elucidated by extensive 1D, 2D NMR, and ESI HR mass measurements, and by comparison with literature data...
December 27, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29260409/application-of-updated-guidelines-on-diastolic-dysfunction-in-patients-with-severe-sepsis-and-septic-shock
#19
David J Clancy, Timothy Scully, Michel Slama, Stephen Huang, Anthony S McLean, Sam R Orde
BACKGROUND: Left ventricular diastolic dysfunction is suggested to be associated with higher mortality in severe sepsis and septic shock, yet the methods of diagnosis described in the literature are often inconsistent. The recently published 2016 American Society of Echocardiography and European Association of Cardiovascular Imaging (ASE/EACVI) guidelines offer the opportunity to apply a simple pragmatic diagnostic algorithm for the detection of diastolic dysfunction; however, it has not been tested in this cohort...
December 19, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/29245061/risk-and-prognosis-of-cancer-after-upper-extremity-deep-venous-thrombosis-a-population-based-cohort-study
#20
Kasper Adelborg, Erzsébet Horváth-Puhó, Jens Sundbøll, Paolo Prandoni, Anne Ording, Henrik Toft Sørensen
INTRODUCTION: The association between lower-extremity venous thrombosis and cancer is well-established. However, the extent to which upper-extremity deep venous thrombosis (U-DVT) is a marker of cancer and a prognostic factor for all-cause mortality remains poorly understood. We examined the risk of cancer after a diagnosis of U-DVT compared with cancer risk in the general population. MATERIALS AND METHODS: Using Danish nationwide population-based medical registries, we identified all patients with first-time U-DVT during 1980-1993 and 2000-2013...
November 22, 2017: Thrombosis Research
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