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https://www.readbyqxmd.com/read/28442289/hla-a-b-and-c-allele-and-haplotype-frequencies-defined-by-next-generation-sequencing-in-a-population-of-519-english-blood-donors
#1
Sue Davey, John Ord, Cristina Navarrete, Colin Brown
Whole gene next generation sequencing was used to determine the HLA class I haplotype and allele frequencies in a cohort of 519 English blood donors. This is the first report of HLA frequencies at third field resolution in a UK population with a total of 33, 52 and 30 alleles identified for HLA-A, -B and -C, respectively. Of the 1411 haplotypes determined, 281 had a frequency of greater than 0.05%. Data are available from the Allele Frequencies Net Database under the population name 'England Blood Donors of Mixed Ethnicity', identifier 3392...
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28427355/identifying-and-characterizing-hepatitis-c-virus-hotspots-in-massachusetts-a-spatial-epidemiological-approach
#2
Thomas J Stopka, Michael A Goulart, David J Meyers, Marga Hutcheson, Kerri Barton, Shauna Onofrey, Daniel Church, Ashley Donahue, Kenneth K H Chui
BACKGROUND: Hepatitis C virus (HCV) infections have increased during the past decade but little is known about geographic clustering patterns. METHODS: We used a unique analytical approach, combining geographic information systems (GIS), spatial epidemiology, and statistical modeling to identify and characterize HCV hotspots, statistically significant clusters of census tracts with elevated HCV counts and rates. We compiled sociodemographic and HCV surveillance data (n = 99,780 cases) for Massachusetts census tracts (n = 1464) from 2002 to 2013...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28410030/ecological-release-from-aquatic-predation-is-associated-with-the-emergence-of-marine-blenny-fishes-onto-land
#3
Terry J Ord, Thomas C Summers, Mae M Noble, Christopher J Fulton
An ecological release from competition or predation is a frequent adaptive explanation for the colonization of novel environments, but empirical data are limited. On the island of Rarotonga, several blenny fish species appear to be in the process of colonizing land. Anecdotal observations have implied that aquatic predation is an important factor in prompting such amphibious fish behavior. We provide evidence supporting this hypothesis by demonstrating that amphibious blennies shift their abundance up and down the shoreline to remain above predatory fishes that periodically move into intertidal areas during high tide...
May 2017: American Naturalist
https://www.readbyqxmd.com/read/28403879/spatial-clustering-and-risk-factors-of-malaria-infections-in-bata-district-equatorial-guinea
#4
Diana Gómez-Barroso, Emely García-Carrasco, Zaida Herrador, Policarpo Ncogo, María Romay-Barja, Martín Eka Ondo Mangue, Gloria Nseng, Matilde Riloha, Maria Angeles Santana, Basilio Valladares, Pilar Aparicio, Agustín Benito
BACKGROUND: The transmission of malaria is intense in the majority of the countries of sub-Saharan Africa, particularly in those that are located along the Equatorial strip. The present study aimed to describe the current distribution of malaria prevalence among children and its environment-related factors as well as to detect malaria spatial clusters in the district of Bata, in Equatorial Guinea. METHODS: From June to August 2013 a representative cross-sectional survey using a multistage, stratified, cluster-selected sample was carried out of children in urban and rural areas of Bata District...
April 12, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28403537/cdspectech-a-single-software-suite-for-multiple-chiroptical-spectroscopic-analyses
#5
Cody L Covington, Prasad L Polavarapu
The program CDSpecTech was developed to facilitate the analysis of chiroptical spectra, which include the following: vibrational circular dichroism (VCD) and corresponding vibrational absorption (VA) spectra; vibrational Raman optical activity (VROA) and corresponding vibrational Raman spectra; electronic circular dichroism (ECD) and corresponding electronic absorption (EA) spectra. In addition, the program allows for generating optical rotatory dispersion (ORD) as the Kramers-Kronig transform of ECD spectra...
May 2017: Chirality
https://www.readbyqxmd.com/read/28393700/mammalian-pseudokinase-trib3-in-normal-physiology-and-disease-charting-the-progress-in-old-and-new-avenues
#6
Tiit Örd, Tõnis Örd
Tribbles homolog 3 (TRIB3) is a mammalian gene that is upregulated in response to several types of cell death-inducing cellular stress. The TRIB3 protein is a pseudokinase, a protein kinase-like scaffold with impaired catalytic activity. However, research has revealed it to be prolific at forming protein-protein interactions. By binding to and regulating the activity of several key proteins, including the protein kinase Akt and transcription factors ATF4, CHOP and NF-κB, TRIB3 is at a junction of several signaling pathways...
April 6, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28391174/gis-based-spatial-pattern-analysis-children-with-hepatitis-a-in-turkey
#7
Ahmet Ozgur Dogru, Ruusa Magano David, Necla Ulugtekin, Cigdem Goksel, Dursun Zafer Seker, Seval Sözen
This study aimed to provide an insight into the geographic distribution of Hepatitis A incidence considering their temporal distribution, spatial patterns, hot spots and clusters identification in three different age-group (0-4, 5-9 and 10-14) in Turkey. Province based tabular data, including monthly numbers of Hepatitis A cases in children, and the populations from 2001 to 2011 were used as the basic input of the study. Time series maps were created using Geographic Information Systems (GIS) to introduce the temporal changes in the morbidity rates of Hepatitis A...
April 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/28380866/novel-method-for-determination-of-optical-rotatory-dispersion-spectrum-by-using-line-scan-ccd
#8
Shixin Jiang, Hongzhi Jia, Yu Lei, Xinrong Shen, Junjie Cao, Ning Wang
A novel method is presented for rapid measurement of optical rotatory dispersion (ORD). Light passes through a polarizer, sample and analyzer, to a transmission grating that disperses the collimated light beam. A step-motor rotating stage controlled by a digital signal processor changes the analyzer orientation. The light power is measured by a charge-coupled device (CCD) after each rotating-stage step. The optical rotation angle for each wavelength is determined from the shift between two Malus curves obtained from each CCD pixel...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28377383/risk-of-stroke-in-patients-with-heart-failure-a-population-based-30-year-cohort-study
#9
Kasper Adelborg, Szimonetta Szépligeti, Jens Sundbøll, Erzsébet Horváth-Puhó, Victor W Henderson, Anne Ording, Lars Pedersen, Henrik Toft Sørensen
BACKGROUND AND PURPOSE: The long-term risk of specific stroke subtypes among heart failure patients is largely unknown. We examined short-term and long-term risk of ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in heart failure patients and in a general population comparison cohort. METHODS: In this nationwide cohort study (1980-2012), we used Danish population-based medical registries to identify and follow (1) all patients hospitalized for the first time with heart failure and (2) a birth year-, sex-, and calendar year-matched general population comparison cohort...
April 4, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28370488/asymmetric-sequential-cu-catalyzed-1-6-1-4-conjugate-additions-of-hard-nucleophiles-to-cyclic-dienones-determination-of-absolute-configurations-and-origins-of-enantioselectivity
#10
Marc Mauduit, Charlie Blons, Marie S T Morin, Thibault E Schmid, Thomas Vives, Sophie Colombel-Rouen, Olivier Baslé, Thibault Reynaldo, Cody L Covington, Stephanie Halbert, Sean N Cuskelly, Paul V Bernhardt, Craig M Williams, Jeanne Crassous, Prasad L Polavarapu, Christophe Crévisy, Hélène Gérard
The first stereo-controlled Cu-catalyzed sequential 1,6/1,4-asymmetric conjugate addition (ACA) of C-metalated hard nucleophiles to cyclic dienones is reported. The use of DiPPAM, followed by a phosphoramidite, as the stereoinducing ligands facilitated both high ee's for the 1,6-ACA and high de's for the 1,4-ACA reaction components, thus affording enantio-enriched 1,3-dialkylated moieties. The absolute configurations were determined using vibrational circular dichroism (VCD) and optical rotatory dispersion (ORD) spectroscopy, in combination with DFT calculations and X-Ray analysis...
April 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28359633/the-role-of-perineural-invasion-in-treatment-decisions-for-oral-cancer-patients-a-review-of-the-literature
#11
Ioannis Chatzistefanou, Joshua Lubek, Konstantinos Markou, Robert A Ord
PURPOSE: The role of perineural invasion (PNI) in the management of patients with oral squamous cell carcinoma (OSSC) is still controversial, and there is no consensus regarding the most appropriate therapeutic approach. The purpose of this study is to review the findings in the literature describing OSCC as a neurotropic malignancy, with the aim of correlating perineural invasion with treatment decisions and disease prognosis. MATERIALS AND METHODS: A literature search was conducted of references based on the MEDLINE and Cochrane Database of Systematic Reviews, with subject keywords including four main categories: perineural invasion, perineural spread, oral squamous cell cancinoma, neurotropic carcinoma...
February 24, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28333544/joint-fluid-bone-marrow-edemalike-changes-and-ganglion-cysts-in-the-pediatric-wrist-features-that-may-mimic-pathologic-abnormalities-follow-up-of-a-healthy-cohort
#12
Derk F M Avenarius, Lil-Sofie Ording Müller, Karen Rosendahl
OBJECTIVE: The presence of findings at wrist MRI that may mimic disease is a diagnostic problem. The purpose of this study is to examine the occurrence of bone marrow changes resembling edema, joint fluid, and ganglion cysts over time, in a cohort of healthy children. MATERIALS AND METHODS: Seventy-four of 89 healthy children included in a study of normal MRI findings of the wrists were reexamined after a period of 4 years, using the same 1.5-T MRI technique-namely, a coronal T1-weighted and a T2-weighted fat-saturated sequence...
March 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28319008/structure-of-yeast-osbp-related-protein-osh1-reveals-key-determinants-for-lipid-transport-and-protein-targeting-at-the-nucleus-vacuole-junction
#13
Mohammad Kawsar Manik, Huiseon Yang, Junsen Tong, Young Jun Im
Yeast Osh1 belongs to the oxysterol-binding protein (OSBP) family of proteins and contains multiple targeting modules optimized for lipid transport at the nucleus-vacuole junction (NVJ). The key determinants for NVJ targeting and the role of Osh1 at NVJs have remained elusive because of unknown lipid specificities. In this study, we determined the structures of the ankyrin repeat domain (ANK), and OSBP-related domain (ORD) of Osh1, in complex with Nvj1 and ergosterol, respectively. The Osh1 ANK forms a unique bi-lobed structure that recognizes a cytosolic helical segment of Nvj1...
April 4, 2017: Structure
https://www.readbyqxmd.com/read/28317278/species-traits-help-predict-small-mammal-responses-to-habitat-homogenization-by-an-invasive-grass
#14
Joseph P Ceradini, Anna D Chalfoun
Invasive plants can negatively affect native species, however, the strength, direction, and shape of responses may vary depending on the type of habitat alteration and the natural history of native species. To prioritize conservation of vulnerable species, it is therefore critical to effectively predict species' responses to invasive plants, which may be facilitated by a framework based on species' traits. We studied the population and community responses of small mammals and changes in habitat heterogeneity across a gradient of cheatgrass (Bromus tectorum) cover, a widespread invasive plant in North America...
March 20, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28301514/apolipoprotein-d-expression-does-not-predict-breast-cancer-recurrence-among-tamoxifen-treated-patients
#15
Daniella Klebaner, Stephen Hamilton-Dutoit, Thomas Ahern, Anatasha Crawford, Thomas Jakobsen, Deirdre P Cronin-Fenton, Per Damkier, Emiel Janssen, Anders Kjaersgaard, Anne Gulbech Ording, Håvard Søiland, Henrik Toft Sørensen, Timothy L Lash, Ylva Hellberg
BACKGROUND: Apolipoprotein D (ApoD) has been proposed as a predictor of breast cancer recurrence among estrogen receptor-positive (ER+), tamoxifen-treated patients. METHODS: We conducted a population-based case-control study nested in a population of 11,251 women aged 35-69 years at diagnosis with Stage I-III breast cancer between 1985 and 2001 on Denmark's Jutland Peninsula and registered with the Danish Breast Cancer Cooperative Group. We identified 541 recurrent or contralateral breast cancers cases among women with ER+ disease treated with tamoxifen for at least 1 year and 300 cases in women with ER- disease never treated with tamoxifen...
2017: PloS One
https://www.readbyqxmd.com/read/28269036/assessment-of-frequency-specific-auditory-steady-state-response-using-amplitude-modulation-with-2-order-exponential-envelope
#16
Pablo Cevallos-Larrea, Thobias Pereira, Wagner Santos, Silvana M Frota, Antonio F Infantosi, Roberto M Ichinose, Carlos Tierra-Criollo
This study investigated the performance of Frequency Specific Auditory Steady-State Response (FS-ASSR) detection elicited by the amplitude modulated tone with 2-order exponential envelope (AM2), using objective response detection (ORD) techniques of Spectral F-Test (SFT) and Magnitude Squared Coherence (MSC). ASSRs from 24 normal hearing adults were obtained during binaural multi-tone stimulation of amplitude-modulation (AM) and AM2 at intensities of 60, 45 and 30 dBSPL. The carrier frequencies were 500, 1000, 2000, and 4000 Hz, modulated between 77 and 105 Hz...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28248970/an-eocene-orthocone-from-antarctica-shows-convergent-evolution-of-internally-shelled-cephalopods
#17
Larisa A Doguzhaeva, Stefan Bengtson, Marcelo A Reguero, Thomas Mörs
BACKGROUND: The Subclass Coleoidea (Class Cephalopoda) accommodates the diverse present-day internally shelled cephalopod mollusks (Spirula, Sepia and octopuses, squids, Vampyroteuthis) and also extinct internally shelled cephalopods. Recent Spirula represents a unique coleoid retaining shell structures, a narrow marginal siphuncle and globular protoconch that signify the ancestry of the subclass Coleoidea from the Paleozoic subclass Bactritoidea. This hypothesis has been recently supported by newly recorded diverse bactritoid-like coleoids from the Carboniferous of the USA, but prior to this study no fossil cephalopod indicative of an endochochleate branch with an origin independent from subclass Bactritoidea has been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28241520/optical-rotatory-dispersion-measurement-approach-using-the-nonlinear-behavior-of-the-geometric-phase
#18
Makoto Ginya, Makoto Kimura, Tetsuo Iwata
We propose a method for high-sensitivity optical rotatory dispersion (ORD) measurement of optically active samples that takes advantage of the nonlinear behavior of the geometric phase (GP). To measure the GP as a function of wavelength, we use a multichannel Fourier transform spectrometer (MC-FTS) that is based on Savart plate birefringent-polarization interference, into which we newly insert a zeroth-order quarter-wave plate (QWP). The modified MC-FTS allows us to measure the wavelength dependence of the GP and thus that of the optical rotation angle due to the sample...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28227250/assessment-of-frequency-specific-auditory-steady-state-response-using-amplitude-modulation-with-2-order-exponential-envelope
#19
Pablo Cevallos-Larrea, Thobias Pereira, Wagner Santos, Silvana M Frota, Antonio F Infantosi, Roberto M Ichinose, Carlos Tierra-Criollo, Pablo Cevallos-Larrea, Thobias Pereira, Wagner Santos, Silvana M Frota, Antonio F Infantosi, Roberto M Ichinose, Carlos Tierra-Criollo, Pablo Cevallos-Larrea, Wagner Santos, Silvana M Frota, Carlos Tierra-Criollo, Antonio F Infantosi, Thobias Pereira, Roberto M Ichinose
This study investigated the performance of Frequency Specific Auditory Steady-State Response (FS-ASSR) detection elicited by the amplitude modulated tone with 2-order exponential envelope (AM(2)), using objective response detection (ORD) techniques of Spectral F-Test (SFT) and Magnitude Squared Coherence (MSC). ASSRs from 24 normal hearing adults were obtained during binaural multi-tone stimulation of amplitude-modulation (AM) and AM(2) at intensities of 60, 45 and 30 dBSPL. The carrier frequencies were 500, 1000, 2000, and 4000 Hz, modulated between 77 and 105 Hz...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225789/non-melanoma-skin-cancer-and-risk-of-alzheimer-s-disease-and-all-cause-dementia
#20
Sigrun A J Schmidt, Anne G Ording, Erzsébet Horváth-Puhó, Henrik T Sørensen, Victor W Henderson
Cancer patients may be at decreased risk of Alzheimer's disease. This hypothesis is best developed for non-melanoma skin cancer (NMSC), but supportive epidemiological data are sparse. We therefore conducted a nationwide cohort study of the association between NMSC and Alzheimer's disease (main outcome) and all-cause dementia. Using Danish medical databases, we identified adults diagnosed with NMSC between 1 January 1980 and 30 November 2013 (n = 216,221) and a comparison cohort of five individuals matched to each NMSC patient by sex and birth year (n = 1,081,097)...
2017: PloS One
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