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Stefania Vergura, Ernesto Santoro, Marco Masi, Antonio Evidente, Patrizia Scafato, Stefano Superchi, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate
Jonquailine, a new alkaloid recently isolated from Narcissus jonquilla quail, an Amaryllidacea species cultivated for its fragrance flowers in Europe and USA, shows very significant anti-proliferative activity against several malignant cancer cell types. Although it was reported that this activity is related to the functionalities and to its stereochemistry at C-8 of B ring, the absolute configuration at this stereocenter was not known. Density functional theory (DFT) calculations of chiroptical properties, namely electronic circular dichroism (ECD), vibrational circular dichroism (VCD), and optical rotatory dispersion (ORD) are employed here to complete assignment of absolute configuration of jonquailine, and then, by extension, to its analogues pretazettine and 8-O-methylpretazettine...
June 18, 2018: Fitoterapia
Jonathan L Pitchford, Michael Garcia, Eric E Pulis, Ashley Millan Ambert, Andrew J Heaton, Moby Solangi
The co-occurrence of the Deepwater Horizon oil spill and the northern Gulf of Mexico cetacean Unusual Mortality Event have raised questions about the stability of inshore bottlenose dolphin (Tursiops truncatus) populations throughout the region. Several factors could have contributed to the ongoing event, but little attention has been paid to the potential effects of increased search effort and reporting of strandings associated with oil spill response activities, which were widespread for an extended period...
2018: PloS One
Anders Kindberg Boysen, Karen-Lise Spindler, Morten Høyer, Frank Viborg Mortensen, Thomas Decker Christensen, Dóra Kormendine Farkas, Anne Gulbech Ording
About 10-20% of patients with metastatic colorectal cancer (mCRC) are candidates for metastasis directed therapies such as surgical resection, ablation and stereotactic radiotherapy. We examined the temporal changes in use of metastasis directed therapies and established prognostic factors for survival in a nationwide cohort study. The Danish nationwide medical registries were used to retrieve data on treatment for liver and/or lung metastasis in patients with metastatic colorectal cancer in the period 2000-2013...
June 19, 2018: International Journal of Cancer. Journal International du Cancer
Ngai Sze Wong, Lei Chen, Joseph D Tucker, Peizhen Zhao, Beng Tin Goh, Chin Man Poon, Ligang Yang, Bin Yang, Heping Zheng, Shujie Huang
There was a varied spatial distribution of reported syphilis cases across cities in South China. This study aims to identify and describe spatiotemporal clusters of primary and secondary syphilis (P/S) cases in this region. Reported syphilis cases in Guangdong Province, China, from January 2014 to June 2015 were collected from the national centralized reporting system. Spatiotemporal clusters of P/S were identified and cross-validated by calculating local Moran's I, performing hotspot analysis (Getis-Ord Gi*), and constructing a discrete Poisson model in SaTScan...
June 14, 2018: Scientific Reports
Chun-Chao Zhao, Jie Shen, Jia Chen, Jian-Hua Shao, Ke-Huan Li, Wen-Yan Gu, Ben-Jie Miao
Two new phenolic glycoside compounds (1, 2) and ten known analogues (3-12) have been isolated from the ethanolic extract of Brassica rapa flowers and identified as 2-O-β-d-glucopyranosyl-(1S)-(4-methoxyphenyl)ethylene glycol (1), 2-(4-O-β-d-allopyranosyl)phenyl-ethanol (2), 2-O-β-d-glucopyranosyl-(1S)-phenylethylene glycol (3), 2-O-β-d-glucopyranosyl-(1R)-phenylethylene glycol (4), (Z)-p-coumaryl-O-β-d-glucopyranoside (5), phenyl-O-β-d-glucopyranoside (6), 2-phenylethyl-O-β-d-glucopyranoside (7), salidroside (8), 2-(2-hydroxyphenyl)ethanol-O-β-d-glucopyranoside (9), 4-methoxybenzyl-O-β-d-glucopyranoside (10), 2,4,6-trimethoxyphenyl-1-O-β-d-glucopyranoside (11) and sachaliside 1 (12)...
June 11, 2018: Natural Product Research
Benjamin W Chrisinger, Abby C King
BACKGROUND: Identifying elements of one's environment-observable and unobservable-that contribute to chronic stress including the perception of comfort and discomfort associated with different settings, presents many methodological and analytical challenges. However, it also presents an opportunity to engage the public in collecting and analyzing their own geospatial and biometric data to increase community member understanding of their local environments and activate potential environmental improvements...
June 5, 2018: International Journal of Health Geographics
Sebsibe Tadesse, Fikre Enqueselassie, Seifu Hagos
INTRODUCTION: Spatial targeting is advocated as an effective method that contributes for achieving tuberculosis control in high-burden countries. However, there is a paucity of studies clarifying the spatial nature of the disease in these countries. This study aims to identify the location, size and risk of purely spatial and space-time clusters for high occurrence of tuberculosis in Gurage Zone, Southern Ethiopia during 2007 to 2016. MATERIALS AND METHODS: A total of 15,805 patient data that were retrieved from unit TB registers were included in the final analyses...
2018: PloS One
Stéphane Joost, José Haba-Rubio, Rebecca Himsl, Peter Vollenweider, Martin Preisig, Gérard Waeber, Pedro Marques-Vidal, Raphaël Heinzer, Idris Guessous
INTRODUCTION: Daytime sleepiness is highly prevalent in the general adult population and has been linked to an increased risk of workplace and vehicle accidents, lower professional performance and poorer health. Despite the established relationship between noise and daytime sleepiness, little research has explored the individual-level spatial distribution of noise-related sleep disturbances. We assessed the spatial dependence of daytime sleepiness and tested whether clusters of individuals exhibiting higher daytime sleepiness were characterized by higher nocturnal noise levels than other clusters...
May 31, 2018: International Journal of Hygiene and Environmental Health
Helen L Ord, Michael J Griksaitis
Point of care ultrasound (POCUS) is well established in adult emergency medicine and critical care. It is used for immediate diagnosis and evaluation of the impact of bedside interventions in the acutely unwell child. This article highlights how ultrasound can be helpful in paediatric practice when dealing with the neonate, infant or older child with undifferentiated respiratory distress, respiratory failure or ventilation problems. It highlights indications for use, key diagnostic features of common pathology and outlines the benefits of POCUS in everyday practice...
May 25, 2018: Archives of Disease in Childhood. Education and Practice Edition
Michael Riccabona, M Luisa Lobo, Thomas A Augdal, Fred Avni, Johan Blickman, Costanza Bruno, M Beatrice Damasio, Kassa Darge, Hans-Joachim Mentzel, Marcello Napolitano, Aikaterini Ntoulia, Frederica Papadopoulou, Philippe Petit, Magdalena M Woźniak, Lil-Sofie Ording-Müller
At the European Society of Paediatric Radiology (ESPR) annual meeting 2017 in Davos, Switzerland, the ESPR Abdominal (gastrointestinal and genitourinary) Imaging Task Force set out to complete the suggestions for paediatric abdominal imaging and its procedural recommendations. Some final topics were addressed including how to perform paediatric gastrointestinal ultrasonography. Based on the recent approval of ultrasound (US) contrast agents for paediatric use, important aspects of paediatric contrast-enhanced US were revisited...
May 23, 2018: Pediatric Radiology
Pavla Hanousková, Petr Táborský, Ivan Čepička
We report the discovery of a new genus of heterolobosean flagellates, Dactylomonas gen. nov., with two species, D. venusta sp. nov. and D. crassa sp. nov. Phylogenetic analysis of the SSU rRNA gene showed that Dactylomonas is closely related to the amoeba Selenaion, the deepest-branching lineage of Tetramitia. Dactylomonads possess two flagella, and ultrastructural studies revealed an unexpected organization of the flagellar apparatus, which resembled Pharyngomonada (the second lineage of Heterolobosea) instead of Tetramitia: basal bodies were orthogonal to each other and a putative root R1 was present in the mastigont...
May 23, 2018: Journal of Eukaryotic Microbiology
Dimitry Y Sorokin, Alexander Y Merkel, Ben Abbas, Kira S Makarova, W Irene C Rijpstra, M Koenen, Jaap S Sinninghe Damsté, Erwin A Galinski, Eugene V Koonin, Mark C M van Loosdrecht
Methanogenic enrichments from hypersaline lakes at moderate thermophilic conditions have resulted in the cultivation of an unknown deep lineage of euryarchaeota related to the class Halobacteria. Eleven soda lake isolates and three salt lake enrichment cultures were methyl-reducing methanogens that utilize C1 methylated compounds as electron acceptors and H2 or formate as electron donors, but they were unable to grow on either substrates alone or to form methane from acetate. They are extreme halophiles, growing optimally at 4 M total Na+ and the first representatives of methanogens employing the 'salt-in' osmoprotective mechanism...
May 21, 2018: International Journal of Systematic and Evolutionary Microbiology
Srinivasa Rao Mutheneni, Rajasekhar Mopuri, Suchithra Naish, Deepak Gunti, Suryanarayana Murty Upadhyayula
Background and objectives: Dengue is an emerging and re-emerging infectious disease, transmitted by mosquitoes. It is mostly prevalent in tropical and sub-tropical regions of the world, particularly, in Asia-Pacific region. To understand the epidemiology and spatial distribution of dengue, a retrospective surveillance study was conducted in the state of Andhra Pradesh, India during 2011-2013. Material and methods: District-wise disease endemicity levels were mapped through geographical information system (GIS) tools...
February 2018: Parasite Epidemiology and Control
Derk Frederik Matthaus Avenarius, Charlotte Nusman, Clara Malattia, Laura Tanturri de Horatio, Karen Rosendahl, Mario Maas, Lil-Sofie Ording Müller
Wrist involvement occurs in about one-quarter of patients diagnosed with juvenile idiopathic arthritis (JIA), increasing to 40% 5 years after diagnosis. The imaging appearances, both for active inflammation and permanent change, differ from those seen in adult rheumatoid arthritis; therefore, a child-specific approach is crucial for correct assessment. In this review article, we provide an update on the current status for imaging wrist JIA, with a focus on evidence-based practice.
June 2018: Pediatric Radiology
C Brehony, J Cullinan, M Cormican, D Morris
Shiga toxigenic Escherichia coli (STEC) are pathogenic E. coli that cause infectious diarrhoea. In some cases infection may be complicated by renal failure and death. The incidence of human infection with STEC in Ireland is the highest in Europe. The objective of the study was to examine the spatial incidence of human STEC infection in a region of Ireland with significantly higher rates of STEC incidence than the national average and to identify possible risk factors of STEC incidence at area level. Anonymised laboratory records (n = 379) from 2009 to 2015 were obtained from laboratories serving three counties in the West of Ireland...
May 12, 2018: Science of the Total Environment
Rebecca Troisi, Anne Gulbech Ording, Tom Grotmol, Ingrid Glimelius, Anders Engeland, Mika Gissler, Britton Trabert, Anders Ekbom, Laura Madanat-Harjuoja, Henrik Toft Sørensen, Steinar Tretli, Tone Bjørge
Certain features of pregnancy are important risk factors for breast cancer, such as protection afforded by young age at first birth. Preeclampsia, a pregnancy complication, is associated with reduced maternal breast cancer risk. However, questions remain regarding causality, biological mechanisms and the relation of other hypertensive conditions to risk. We conducted a population-based case-control study of breast cancer cases (n=116,196) in parous women identified through linkage of birth and cancer registries in Denmark, Finland, Norway and Sweden (1967-2013), including up to 10 matched controls per case (n=1,147,192) sampled from the birth registries (complete data were not available on all variables)...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
Christian Reuss Mikkelsen, Jakob Ross Jornil, Ljubica Vukelic Andersen, Jørgen Bo Hasselstrøm, Sebastian Polak
Methadone-related poisoning has been found to be the leading and increasing cause of death among intoxication cases in several countries. Aside from respiratory depression, methadone is known to cause QT-prolongation, which may lead to sudden cardiac death. Concentrations in heart tissue should be more accurate for estimating cardiotoxic effects. The aim of this study was to investigate whether the effect of methadone on the QT-interval could be simulated and whether the concentrations in heart tissues allowed for better prediction of the Bazett corrected QT-interval (QTcB)...
May 11, 2018: Toxicology Mechanisms and Methods
Antoine Vieillard-Baron, R Naeije, F Haddad, H J Bogaard, T M Bull, N Fletcher, T Lahm, S Magder, S Orde, G Schmidt, M R Pinsky
INTRODUCTION: This is a state-of-the-art article of the diagnostic process, etiologies and management of acute right ventricular (RV) failure in critically ill patients. It is based on a large review of previously published articles in the field, as well as the expertise of the authors. RESULTS: The authors propose the ten key points and directions for future research in the field. RV failure (RVF) is frequent in the ICU, magnified by the frequent need for positive pressure ventilation...
May 9, 2018: Intensive Care Medicine
Camilla Sköld, Tone Bjørge, Anders Ekbom, Anders Engeland, Mika Gissler, Tom Grotmol, Laura Madanat, Anne Gulbech Ording, Olof Stephansson, Britton Trabert, Steinar Tretli, Rebecca Troisi, Henrik Toft Sørensen, Ingrid Glimelius
Epithelial ovarian cancer is a fatal disease of largely unknown etiology. Higher parity is associated with reduced risk of ovarian cancer. However, among parous women, the impact of pregnancy-related factors on risk is not well understood. This population-based case-control study included all parous women with epithelial ovarian cancer in Denmark, Finland, Norway and Sweden during 1967-2013 (n=10,957) and up to 10 matched controls (n=107,864). We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for pregnancy-related factors and ovarian cancer risk by histological subtype...
May 8, 2018: International Journal of Cancer. Journal International du Cancer
Varvara I Nikolayenko, Lisa M van Wyk, Orde Q Munro, Leonard J Barbour
A solvatochromic dinuclear copper(ii) metallocycle effectively traps tetrahydrofuran, diethyl ether and pentane significantly above their boiling points. X-ray crystallography, EPR and UV-visible spectroscopy were used to delineate an empirical relationship between the guest-induced structural perturbation of the metallocycle, the ligand field splitting parameter Δ (νmax), and the EPR g-values of the inclusion compounds, thereby elucidating the solvatochromic mechanism.
May 8, 2018: Chemical Communications: Chem Comm
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