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https://www.readbyqxmd.com/read/29658156/rhizarian-novel-clade-10-revealed-as-abundant-and-diverse-planktonic-and-terrestrial-flagellates-including-aquavolon-n-gen
#1
David Bass, D V Tikhonenkov, R Foster, P Dyal, J Janouskovec, P J Keeling, M Gardner, S Neuhauser, H Hartikainen, A P Mylnikov, C Berney
Rhizarian 'Novel Clade 10' (NC10) is frequently detected by 18S rRNA gene sequencing studies in freshwater planktonic samples. We describe a new genus and two species of eukaryovorous biflagellate protists, Aquavolon hoantrani n. gen. n. sp., and A. dientrani n. gen. n. sp., which represent the first morphologically characterized members of NC10, here named Aquavolonida ord. nov.. The slightly metabolic cells possess naked heterodynamic flagella, whose kinetosomes lie at a right angle to each other and are connected by at least one fibril...
April 15, 2018: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/29617402/carnivore-hotspots-in-peninsular-malaysia-and-their-landscape-attributes
#2
Shyamala Ratnayeke, Frank T van Manen, Gopalasamy Reuben Clements, Noor Azleen Mohd Kulaimi, Stuart P Sharp
Mammalian carnivores play a vital role in ecosystem functioning. However, they are prone to extinction because of low population densities and growth rates, and high levels of persecution or exploitation. In tropical biodiversity hotspots such as Peninsular Malaysia, rapid conversion of natural habitats threatens the persistence of this vulnerable group of animals. Here, we carried out the first comprehensive literature review on 31 carnivore species reported to occur in Peninsular Malaysia and updated their probable distribution...
2018: PloS One
https://www.readbyqxmd.com/read/29609252/-spatial-distribution-characteristics-of-tuberculosis-and-its-visualization-in-qinghai-province-2014-2016
#3
H X Rao, Z F Cai, L L Xu, Y Shi
Objective: To analyze the spatial distribution of tuberculosis (TB) and identify the clustering areas in Qinghai province from 2014 to 2016, and provide evidence for the prevention and control of TB. Methods: The data of pulmonary TB cases confirmed by clinical and laboratory diagnosis in Qinghai during this period were collected from National Disease Reporting Information System. The visualization of annual reported incidence, three-dimensional trend analysis and local Getis-Ord G(i) (*) spatial autocorrelation analysis of TB were performed by using software ArcGIS 10...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29595416/proposal-for-a-new-classification-of-a-deep-branching-bacterial-phylogenetic-lineage-transfer-of-coprothermobacter-proteolyticus-and-coprothermobacter-platensis-to-coprothermobacteraceae-fam-nov-within-coprothermobacterales-ord-nov-coprothermobacteria-classis
#4
María Elisa Pavan, Esteban E Pavan, Stefanie P Glaeser, Claudia Etchebehere, Peter Kämpfer, María Julia Pettinari, Nancy I López
The genus Coprothermobacter (initially named Thermobacteroides) is currently placed within the phylum Firmicutes. Early 16S rRNA gene based phylogenetic studies pointed out the great differences between Coprothermobacter and other members of the Firmicutes, revealing that it constitutes a new deep branching lineage. Over the years, several studies based on 16S rRNA gene and whole genome sequences have indicated that Coprothermobacter is very distant phylogenetically to all other bacteria, supporting its placement in a distinct deeply rooted novel phylum...
March 29, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29572464/concurrent-action-of-purifying-selection-and-gene-conversion-results-in-extreme-conservation-of-the-major-stress-inducible-hsp70-genes-in-mammals
#5
Kyle Hess, Ryan Oliverio, Peter Nguyen, Dat Le, Jacqueline Ellis, Brianna Kdeiss, Sara Ord, Dimitra Chalkia, Nikolas Nikolaidis
Several evolutionary mechanisms alter the fate of mutations and genes within populations based on their exhibited functional effects. To understand the underlying mechanisms involved in the evolution of the cellular stress response, a very conserved mechanism in the course of organismal evolution, we studied the patterns of natural genetic variation and functional consequences of polymorphisms of two stress-inducible Hsp70 genes. These genes, HSPA1A and HSPA1B, are major orchestrators of the cellular stress response and are associated with several human diseases...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29556819/phylogenetic-framework-for-the-phylum-tenericutes-based-on-genome-sequence-data-proposal-for-the-creation-of-a-new-order-mycoplasmoidales-ord-nov-containing-two-new-families-mycoplasmoidaceae-fam-nov-and-metamycoplasmataceae-fam-nov-harbouring-eperythrozoon
#6
Radhey S Gupta, Sahil Sawnani, Mobolaji Adeolu, Seema Alnajar, Aharon Oren
The genus Mycoplasma, including species earlier classified in the genera Eperythrozoon and Haemobartonella, contains ~ 120 species and constitutes an extensively polyphyletic assemblage of bacteria within the phylum Tenericutes. Due to their small genome sizes and lack of unique characteristics, the relationships among the mycoplasmas/Tenericutes are not reliably discerned. Using genome sequences for 140 Tenericutes, their evolutionary relationships were examined using multiple independent approaches. Phylogenomic trees were constructed for 63 conserved proteins, 45 ribosomal proteins, three main subunits of RNA polymerase and 16S rRNA gene sequences...
March 20, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29556421/normative-ultrasound-references-for-the-paediatric-wrist-dorsal-soft-tissues
#7
Karen Rosendahl, Ingvild Sævold Bruserud, Ninnie Oehme, Pétur Benedikt Júlíusson, Laura Tanturri de Horatio, Lil-Sofie Ording Müller, Silvia Magni-Manzoni
Objective: To report novel ultrasound (US) references for the healthy paediatric wrist. Methods: Healthy children and adolescents had an US examination including Doppler, of the right wrist, using a mid-sagittal image through the radiocarpal (RC)/midcarpal (MC) joints. These features were noted: appearances and depth of the recess, with an additional measurement in the flexed position and number of Doppler signals within the recess in close proximity to the joint...
2018: RMD Open
https://www.readbyqxmd.com/read/29534104/genotyping-and-spatial-analysis-of-pulmonary-tuberculosis-and-diabetes-cases-in-the-state-of-veracruz-mexico
#8
Francles Blanco-Guillot, M Lucía Castañeda-Cediel, Pablo Cruz-Hervert, Leticia Ferreyra-Reyes, Guadalupe Delgado-Sánchez, Elizabeth Ferreira-Guerrero, Rogelio Montero-Campos, Miriam Bobadilla-Del-Valle, Rosa Areli Martínez-Gamboa, Pedro Torres-González, Norma Téllez-Vazquez, Sergio Canizales-Quintero, Mercedes Yanes-Lane, Norma Mongua-Rodríguez, Alfredo Ponce-de-León, José Sifuentes-Osornio, Lourdes García-García
BACKGROUND: Genotyping and georeferencing in tuberculosis (TB) have been used to characterize the distribution of the disease and occurrence of transmission within specific groups and communities. OBJECTIVE: The objective of this study was to test the hypothesis that diabetes mellitus (DM) and pulmonary TB may occur in spatial and molecular aggregations. MATERIAL AND METHODS: Retrospective cohort study of patients with pulmonary TB. The study area included 12 municipalities in the Sanitary Jurisdiction of Orizaba, Veracruz, México...
2018: PloS One
https://www.readbyqxmd.com/read/29503478/fungal-planet-description-sheets-625-715
#9
P W Crous, M J Wingfield, T I Burgess, A J Carnegie, G E St J Hardy, D Smith, B A Summerell, J F Cano-Lira, J Guarro, J Houbraken, L Lombard, M P Martín, M Sandoval-Denis, A V Alexandrova, C W Barnes, I G Baseia, J D P Bezerra, V Guarnaccia, T W May, M Hernández-Restrepo, A M Stchigel, A N Miller, M E Ordoñez, V P Abreu, T Accioly, C Agnello, A Agustin Colmán, C C Albuquerque, D S Alfredo, P Alvarado, G R Araújo-Magalhães, S Arauzo, T Atkinson, A Barili, R W Barreto, J L Bezerra, T S Cabral, F Camello Rodríguez, R H S F Cruz, P P Daniëls, B D B da Silva, D A C de Almeida, A A de Carvalho Júnior, C A Decock, L Delgat, S Denman, R A Dimitrov, J Edwards, A G Fedosova, R J Ferreira, A L Firmino, J A Flores, D García, J Gené, A Giraldo, J S Góis, A A M Gomes, C M Gonçalves, D E Gouliamova, M Groenewald, B V Guéorguiev, M Guevara-Suarez, L F P Gusmão, K Hosaka, V Hubka, S M Huhndorf, M Jadan, Ž Jurjević, B Kraak, V Kučera, T K A Kumar, I Kušan, S R Lacerda, S Lamlertthon, W S Lisboa, M Loizides, J J Luangsa-Ard, P Lysková, W P Mac Cormack, D M Macedo, A R Machado, E F Malysheva, P Marinho, N Matočec, M Meijer, A Mešić, S Mongkolsamrit, K A Moreira, O V Morozova, K U Nair, N Nakamura, W Noisripoom, I Olariaga, R J V Oliveira, L M Paiva, P Pawar, O L Pereira, S W Peterson, M Prieto, E Rodríguez-Andrade, C Rojo De Blas, M Roy, E S Santos, R Sharma, G A Silva, C M Souza-Motta, Y Takeuchi-Kaneko, C Tanaka, A Thakur, M Th Smith, Z Tkalčec, N Valenzuela-Lopez, P van der Kleij, A Verbeken, M G Viana, X W Wang, J Z Groenewald
Novel species of fungi described in this study include those from various countries as follows: Antarctica : Cadophora antarctica from soil. Australia : Alfaria dandenongensis on Cyperaceae , Amphosoma persooniae on Persoonia sp., Anungitea nullicana on Eucalyptus sp . , Bagadiella eucalypti on Eucalyptus globulus , Castanediella eucalyptigena on Eucalyptus sp., Cercospora dianellicola on Dianella sp., Cladoriella kinglakensis on Eucalyptus regnans , Cladoriella xanthorrhoeae (incl. Cladoriellaceae fam. nov...
December 2017: Persoonia
https://www.readbyqxmd.com/read/29483621/the-efficacy-of-ranolazine-on-e1784k-is-altered-by-temperature-and-calcium
#10
Mena Abdelsayed, Manpreet Ruprai, Peter C Ruben
E1784K is the most common mixed syndrome SCN5a mutation underpinning both Brugada syndrome type 1 (BrS1) and Long-QT syndrome type 3 (LQT3). The charge reversal mutant enhances the late sodium current (INa ) passed by the cardiac voltage-gated sodium channel (NaV 1.5), delaying cardiac repolarization. Exercise-induced triggers, like elevated temperature and cytosolic calcium, exacerbate E1784K late INa . In this study, we tested the effects of Ranolazine, the late INa blocker, on voltage-dependent and kinetic properties of E1784K at elevated temperature and cytosolic calcium...
February 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29483110/gold-iii-macrocycles-and-chelates-targeting-mycobacterium-tuberculosis-and-mycobacterium-abscessus-evidence-for-inhibition-of-topoisomerase-1a
#11
Rashmi Gupta, Carolina R Felix, Matthew P Akerman, Kate J Akerman, Cathryn A Slabber, Wenjie Wang, Jessie Adams, Lindsey N Shaw, Yuk-Ching Tse-Dinh, Orde Q Munro, Kyle H Rohde
Mycobacterium tuberculosis ( Mtb ) and the fast-growing Mycobacterium abscessus ( Mab ) are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug resistant Mtb strains and the high level of intrinsic resistance of Mab calls for novel drug scaffolds that effectively target both pathogens. In this study, we have evaluated the activity of bis(pyrrolide-imine) gold(III) macrocycles and chelates, originally designed as DNA intercalators capable of targeting human topoisomerase I and II, against Mab and Mtb...
February 26, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29476569/the-role-of-pregnancy-perinatal-factors-and-hormones-in-maternal-cancer-risk-a-review-of-the-evidence
#12
Rebecca Troisi, Tone Bjørge, Mika Gissler, Tom Grotmol, Cari M Kitahara, Solbjørg Makalani Myrtveit Saether, Anne Gulbech Ording, Camilla Sköld, Henrik Toft Sørensen, Britton Trabert, Ingrid Glimelius
An understanding of the origin of cancer is critical for cancer prevention and treatment. Complex biological mechanisms promote carcinogenesis, and there is increasing evidence that pregnancy-related exposures influence fetal growth cell division and organ functioning and may have a long-lasting impact on health and disease susceptibility in the mothers and offspring. Nulliparity is an established risk factor for breast, ovarian, endometrial, and possibly pancreatic cancer, while the risk of kidney cancer is elevated in parous compared with nulliparous women...
February 24, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29462130/risk-of-cancer-in-patients-with-epistaxis-and-haemoptysis
#13
Anne G Ording, Katalin Veres, Dóra K Farkas, Kasper Adelborg, Henrik T Sørensen
BACKGROUND: Respiratory tract bleeding may be a marker of cancer. We quantified the risk of specific cancer types among patients with hospital-based diagnoses of epistaxis and haemoptysis relative to risk in the general population. METHODS: We used Danish, nationwide databases to conduct a population-based cohort study of 80460 patients diagnosed with epistaxis and 18487 patients presenting with haemoptysis (1995-2013). We followed patients until a cancer diagnosis, emigration, death, or 31 December 2013, whichever came first...
February 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29426137/spatial-pattern-and-variations-in-the-prevalence-of-congenital-heart-disease-in-children-aged-4-18%C3%A2-years-in-the-qinghai-tibetan-plateau
#14
Li-Guang Ma, Qiu-Hong Chen, Yuan-Yuan Wang, Jing Wang, Zhou-Peng Ren, Zong-Fu Cao, Yan-Rong Cao, Xu Ma, Bin-Bin Wang
PURPOSE: This study aimed to investigate the spatial distribution pattern of the prevalence of congenital heart disease (CHD) in children in Qinghai-Tibetan Plateau (QTP), a high-altitude region in China. METHODS: Epidemiological data from a survey on the prevalence of CHD in Qinghai Province including 288,066 children (4-18 years) were used in this study. The prevalence and distribution pattern of CHD was determined by sex, CHD subtype, and nationality and altitude...
January 29, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29422548/africa-wide-evaluation-of-host-biomarkers-in-quantiferon-supernatants-for-the-diagnosis-of-pulmonary-tuberculosis
#15
Novel N Chegou, Jayne S Sutherland, Anna-Ritah Namuganga, Paul Lam Corstjens, Annemieke Geluk, Gebremedhin Gebremichael, Joseph Mendy, Stephanus Malherbe, Kim Stanley, Gian D van der Spuy, Magdalena Kriel, Andre G Loxton, Belinda Kriel, Felanji Simukonda, Yonas Bekele, Jacob A Sheehama, Josefina Nelongo, Marieta van der Vyver, Atsbeha Gebrexabher, Habteyes Hailu, Maria M Esterhuyse, Ida Rosenkrands, Claus Aagard, Martin Kidd, Desta Kassa, Adane Mihret, Rawleigh Howe, Jacqueline M Cliff, Amelia C Crampin, Harriet Mayanja-Kizza, Stefan H E Kaufmann, Hazel M Dockrell, Tom H M Ottenhoff, Gerhard Walzl
We investigated host-derived biomarkers that were previously identified in QuantiFERON supernatants, in a large pan-African study. We recruited individuals presenting with symptoms of pulmonary TB at seven peripheral healthcare facilities in six African countries, prior to assessment for TB disease. We then evaluated the concentrations of 12 biomarkers in stored QuantiFERON supernatants using the Luminex platform. Based on laboratory, clinical and radiological findings and a pre-established algorithm, participants were classified as TB disease or other respiratory diseases(ORD)...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29413710/comparing-the-geographic-distribution-and-location-characteristics-of-hiv-seropositive-and-hiv-seronegative-individuals-with-a-diagnosis-of-cancer-living-in-the-southeast-us
#16
Benjamin D Hallowell, Sara W Robb, Kristina W Kintziger
As HIV-seropositive individuals live longer, they are more likely to acquire conditions seen in the general population. Excluding AIDS-defining malignancies, HIV-seropositive individuals are more likely to develop cancer than individuals in the general population. In order to better inform future screening and prevention efforts in this population, we compared the geographic distribution and location characteristics of HIV-seropositive and HIV-seronegative cancer cases in South Carolina (SC). To do this we obtained linked HIV and cancer data from the SC enhanced HIV/AIDS Reporting System and Central Cancer Registry...
February 2018: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/29405101/island-wide-surveillance-of-gastrointestinal-protozoan-infections-on-fiji-by-expanding-lymphatic-filariasis-transmission-assessment-surveys-as-an-access-platform
#17
Sung Hye Kim, Milika Rinamalo, Meleresita Rainima-Qaniuci, Nemani Talemaitoga, Mike Kama, Eric Rafai, John H Lowry, Min-Ho Choi, Sung-Tae Hong, Jaco J Verweij, Louise Kelly-Hope, John Russell Stothard
As part of lymphatic filariasis (LF) transmission assessment surveys (TAS) on Fiji, an island-wide assessment of gastrointestinal protozoan infection was performed through concomitant stool sample collections to investigate the distribution of the protozoan infection. All grade 1 and 2 students of 69 schools in the two main islands were targeted in two phases (one in the Western Division and the other in the Central and Northern, except Taveuni sub-Division of Northern), where fecal samples of 1,800 students were available for coproscopy using the formalin-ether-acetate concentration...
February 5, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29400355/epa-leadership-on-science-innovation-and-decision-support-tools-for-addressing-current-and-future-challenges
#18
Alan D Hecht, Aaron Ferster, Kevin Summers
When the U.S. Environmental Protection Agency (EPA) was established nearly 50 years ago, the nation faced serious threats to its air, land, and water, which in turn impacted human health. These threats were effectively addressed by the creation of EPA (in 1970) and many subsequent landmark environmental legislations which in turn significantly reduced threats to the Nation's environment and public health. A key element of historic legislation is research aimed at dealing with current and future problems. Today we face national and global challenges that go beyond classic media-specific (air, land, water) environmental legislation and require an integrated paradigm of action and engagement based on (1) innovation based on science and technology, (2) stakeholder engagement and collaboration, and (3) public education and support...
October 16, 2017: Jacobs journal of environmental sciences
https://www.readbyqxmd.com/read/29378327/trib3-limits-fgf21-induction-during-in-vitro-and-in-vivo-nutrient-deficiencies-by-inhibiting-c-ebp-atf-response-elements-in-the-fgf21-promoter
#19
Tiit Örd, Daima Örd, Tõnis Örd
Mammals must be able to endure periods of limited food availability, and the liver plays a central role in the adaptation to nutritional stresses. TRIB3 (Tribbles homolog 3) is a cellular stress-inducible gene with a liver-centric expression pattern and it has been implicated in stress response regulation and metabolic control. In the current article, we study the involvement of TRIB3 in responses to nutrient deficiencies, including fasting for up to 48 h in mice. We show that hepatic expression of Trib3 is increased after 48 h of fasting and mice with a targeted deletion of the Trib3 gene present elevated hepatic triglyceride content and liver weight at 48 h, along with an upregulation of lipid utilization genes in the liver...
January 26, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29374211/low-altitude-solar-magnetic-reconnection-type-iii-solar-radio-bursts-and-x-ray-emissions
#20
I H Cairns, V V Lobzin, A Donea, S J Tingay, P I McCauley, D Oberoi, R T Duffin, M J Reiner, N Hurley-Walker, N A Kudryavtseva, D B Melrose, J C Harding, G Bernardi, J D Bowman, R J Cappallo, B E Corey, A Deshpande, D Emrich, R Goeke, B J Hazelton, M Johnston-Hollitt, D L Kaplan, J C Kasper, E Kratzenberg, C J Lonsdale, M J Lynch, S R McWhirter, D A Mitchell, M F Morales, E Morgan, S M Ord, T Prabu, A Roshi, N Udaya Shankar, K S Srivani, R Subrahmanyan, R B Wayth, M Waterson, R L Webster, A R Whitney, A Williams, C L Williams
Type III solar radio bursts are the Sun's most intense and frequent nonthermal radio emissions. They involve two critical problems in astrophysics, plasma physics, and space physics: how collective processes produce nonthermal radiation and how magnetic reconnection occurs and changes magnetic energy into kinetic energy. Here magnetic reconnection events are identified definitively in Solar Dynamics Observatory UV-EUV data, with strong upward and downward pairs of jets, current sheets, and cusp-like geometries on top of time-varying magnetic loops, and strong outflows along pairs of open magnetic field lines...
January 26, 2018: Scientific Reports
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