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https://www.readbyqxmd.com/read/28306719/chromosome-19q13-disruption-alters-expressions-of-cyp2a7-mia-and-mia-rab4b-lncrna-and-contributes-to-fap-like-phenotype-in-apc-mutation-negative-familial-colorectal-cancer-patients
#1
Lai Fun Thean, Yu Hui Wong, Michelle Lo, Carol Loi, Min Hoe Chew, Choong Leong Tang, Peh Yean Cheah
Familial adenomatous polyposis (FAP) is an autosomal-dominantly inherited form of colorectal cancer (CRC) caused by mutation in the adenomatous polyposis coli (APC) gene. Our ability to exhaustively screen for APC mutations identify microsatellite-stable and APC-mutation negative familial CRC patients, enabling us to search for novel genes. We performed genome-wide scan on two affected siblings of one family and 88 ethnicity- and gender-matched healthy controls to identify deletions shared by the siblings. Combined loss of heterozygosity, copy number and allelic-specific copy number analysis uncovered 5 shared deletions...
2017: PloS One
https://www.readbyqxmd.com/read/28296927/harms-benefits-and-costs-of-fecal-immunochemical-testing-versus-guaiac-fecal-occult-blood-testing-for-colorectal-cancer-screening
#2
S Lucas Goede, Linda Rabeneck, Marjolein van Ballegooijen, Ann G Zauber, Lawrence F Paszat, Jeffrey S Hoch, Jean H E Yong, Sonja Kroep, Jill Tinmouth, Iris Lansdorp-Vogelaar
BACKGROUND: The ColonCancerCheck screening program for colorectal cancer (CRC) in Ontario, Canada, is considering switching from biennial guaiac fecal occult blood test (gFOBT) screening between age 50-74 years to the more sensitive, but also less specific fecal immunochemical test (FIT). The aim of this study is to estimate whether the additional benefits of FIT screening compared to gFOBT outweigh the additional costs and harms. METHODS: We used microsimulation modeling to estimate quality adjusted life years (QALYs) gained and costs of gFOBT and FIT, compared to no screening, in a cohort of screening participants...
2017: PloS One
https://www.readbyqxmd.com/read/28293326/line-1-is-preferentially-hypomethylated-within-adenomatous-polyps-in-the-presence-of-synchronous-colorectal-cancer
#3
Alice Chu Jiang, Lela Buckingham, William Barbanera, Amoah Yeboah Korang, Faraz Bishesari, Joshua Melson
BACKGROUND: Conventional tubular adenomas are frequently detected in patients undergoing average risk screening colonoscopy and are over-represented in patients who will develop colorectal cancer (CRC). Whether features of adenomas could serve as predictors of synchronous CRC is not known. Here, we investigate whether global methylation markers, including LINE-1, differ within adenomas in patients with and without synchronous CRC. METHODS: Colorectal tubular/tubulovillous adenomatous polyps in the absence (P group, n = 45) and in the presence of synchronous CRC (PC group, n = 32) were identified...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28293085/octogenarian-patients-with-colorectal-cancer-characterizing-an-emerging-clinical-entity
#4
Hadar Goldvaser, Noa Katz Shroitman, Irit Ben-Aharon, Ofer Purim, Yulia Kundel, Daniel Shepshelovich, Tzippy Shochat, Aaron Sulkes, Baruch Brenner
AIM: To characterize colorectal cancer (CRC) in octogenarians as compared with younger patients. METHODS: A single-center, retrospective cohort study which included patients diagnosed with CRC at the age of 80 years or older between 2008-2013. A control group included consecutive patients younger than 80 years diagnosed with CRC during the same period. Clinicopathological characteristics, treatment and outcome were compared between the groups. Fisher's exact test was used for dichotomous variables and χ(2) was used for variables with more than two categories...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28290629/screening-for-colorectal-cancer-recommendation-statement
#5
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28290488/colorectal-cancer-screening-provides-long-term-benefits
#6
Peter Sidaway
No abstract text is available yet for this article.
March 14, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28288169/the-mir-200-family-is-increased-in-dysplastic-lesions-in-ulcerative-colitis-patients
#7
Amy Lewis, Carla Felice, Tomoko Kumagai, Cecilia Lai, Kriti Singh, Rosemary R Jeffery, Roger Feakins, Eleni Giannoulatou, Alessandro Armuzzi, Noor Jawad, James O Lindsay, Andrew Silver
BACKGROUND: Colorectal cancer (CRC) is a life-threatening complication of ulcerative colitis (UC), and patients are routinely screened for the development of precancerous lesions (dysplasia). However, rates of CRC development in patients with confirmed low-grade dysplasia vary widely between studies, suggesting a large degree of heterogeneity between these lesions that is not detectable macroscopically. A better understanding of the underlying molecular changes that occur in dysplasia will help to identify lesions at higher risk of malignancy...
2017: PloS One
https://www.readbyqxmd.com/read/28286799/a-30-year-old-man-with-three-primary-malignancies-a-case-of-constitutional-mismatch-repair-deficiency
#8
William Rengifo-Cam, Kory Jasperson, Ignacio Garrido-Laguna, Howard Colman, Courtney Scaife, Wade Samowitz, N Jewel Samadder
Constitutional mismatch repair deficiency (CMMRD) is a devastating cancer predisposition syndrome for which clinical manifestations, genetic screening, and cancer prevention strategies are limited. We report a case of CMMRD presenting with metachronous colorectal cancer and brain cancer. Oncologists and gastroenterologists should be aware of the CMMRD syndrome as a rare cause of very early-onset colorectal cancer.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28286066/the-emerging-impact-of-malnutrition-on-surgical-patients-literature-review-and-potential-implications-on-cystectomy-for-bladder-cancer
#9
REVIEW
Conrad M Tobert, Jill M Hamilton-Reeves, Lyse A Norian, Chermaine Hung, Nathan A Brooks, Jeff M Holzbeierlein, Tracy M Downs, Douglas P Robertson, Ruth Grossman, Kenneth G Nepple
PURPOSE: Malnutrition is emerging as a significant factor in patient outcomes. A contemporary review of malnutrition for the urologist has not been performed. We provide a review of the available literature and current standards of care for malnutrition screening, assessment, and intervention with a focus on patients with bladder cancer treated with cystectomy. MATERIALS AND METHODS: Our multi-disciplinary team conducted a PubMed search of available literature on malnutrition focusing on: definition and significance, importance to urologists, screening, assessment, diagnosis, immunologic and economic impact, and interventions...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28283864/lower-gastrointestinal-neuroendocrine-neoplasms-associated-with-hereditary-cancer-syndromes-a-case-series
#10
Trilokesh D Kidambi, Christina Pedley, Amie Blanco, Emily K Bergsland, Jonathan P Terdiman
Lower gastrointestinal (GI) neuroendocrine neoplasms (NENs) of the colon and rectum are uncommon and not traditionally associated with hereditary GI cancer syndromes. However, with widespread implementation of colorectal cancer screening programs, lower GI NENs are being identified with increasing frequency. We report the first case series of six patients with lower GI NENs who were diagnosed with hereditary GI cancer syndromes by germline testing. Two patients presented with poorly differentiated rectal neuroendocrine carcinoma (NECs) with colonic polyposis and were found to have Familial Adenomatous Polyposis and MYH-Associated Polyposis, respectively...
March 10, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28282907/complications-from-surgeries-related-to-ovarian-cancer-screening
#11
Lauren A Baldwin, Edward J Pavlik, Emma Ueland, Hannah E Brown, Kelsey M Ladd, Bin Huang, Christopher P DeSimone, John R van Nagell, Frederick R Ueland, Rachel W Miller
The aim of this study was to evaluate complications of surgical intervention for participants in the Kentucky Ovarian Cancer Screening Program and compare results to those of the Prostate, Lung, Colorectal and Ovarian Cancer Screening trial. A retrospective database review included 657 patients who underwent surgery for a positive screen in the Kentucky Ovarian Cancer Screening Program from 1988-2014. Data were abstracted from operative reports, discharge summaries, and office notes for 406 patients. Another 142 patients with incomplete records were interviewed by phone...
March 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28282021/utilization-of-clinical-preventive-services-for-cancer-and-heart-disease-among-insured-adults-united-states-2015
#12
Anjel Vahratian, Stephen J Blumberg
Data from the National Health Interview Survey •Two-thirds of insured adults aged 50-75 were screened for colorectal cancer within the recommended intervals. •Insured women aged 30-39 (90.5%) were more likely than their older peers to be screened for cervical cancer within the recommended intervals. •Seventy-three percent of insured women aged 50-74 had a mammogram in the past 2 years. •The percentage of insured adults who had a cardiovascular risk screening (blood pressure, blood sugar) within the recommended intervals significantly increased with advancing age for both men and women...
March 2017: NCHS Data Brief
https://www.readbyqxmd.com/read/28281292/assessing-global-transitions-in-human-development-and-colorectal-cancer-incidence
#13
Miranda M Fidler, Freddie Bray, Salvatore Vaccarella, Isabelle Soerjomataram
Colorectal cancer incidence has paralleled increases in human development across most countries. Yet, marked decreases in incidence are now observed in countries that have attained very high human development. Thus, in this study, we explored the relationship between human development and colorectal cancer incidence, and in particular assessed whether national transitions to very high human development are linked to temporal patterns in colorectal cancer incidence. For these analyses, we utilized the Human Development Index (HDI) and annual incidence data from regional and national cancer registries...
March 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28281245/medicare-modernization-and-diffusion-of-endoscopy-in-ffs-medicare
#14
Lee R Mobley, Pedro Amaral, Tzy-Mey Kuo, Mei Zhou, Srimoyee Bose
OBJECTIVE: To examine how FFS Medicare utilization of endoscopy procedures for colorectal cancer (CRC) screening changed after implementation of the Medicare Prescription Drug, Improvement, and Modernization Act (MMA) in 2006, which provided subsidized drug coverage and expanded the geographic availability of Medicare managed care plans across the US. DATA SOURCES/STUDY SETTING: Using secondary data from 100% FFS Medicare enrollees, we analyzed endoscopy utilization during two intervals, 2001-2005 and 2006-2009...
December 2017: Health Economics Review
https://www.readbyqxmd.com/read/28279996/incidence-and-relative-risk-for-developing-cancer-among-patients-with-copd-a-nationwide-cohort-study-in-taiwan
#15
Chung-Han Ho, Yi-Chen Chen, Jhi-Joung Wang, Kuang-Ming Liao
OBJECTIVES: This observational study aimed to examine the incidence of malignant diseases, including specific cancer types, after the diagnosis of chronic obstructive pulmonary disease (COPD) in Taiwanese patients. SETTING: Taiwan's National Health Insurance Research Database. PARTICIPANTS: The definition of a patient with COPD was a patient with a discharge diagnosis of COPD or at least 3 ambulatory visits for COPD. The index date was the date of the first COPD diagnosis...
March 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28279589/difference-of-stage-at-cancer-diagnosis-by-socioeconomic-status-for-four-target-cancers-of-the-national-cancer-screening-program-in-korea-results-from-the-gwangju-and-jeonnam-cancer-registries
#16
Sun-Seog Kweon, Min-Gyeong Kim, Mi-Ran Kang, Min-Ho Shin, Jin-Su Choi
BACKGROUND: The aim of this study was to evaluate whether stage at cancer diagnosis differed according to patient economic status. METHODS: A total of 10,528 patients with cancer of the stomach, colorectum, breast, or cervix, which are target organs of the Korean National Cancer Screening Program (NCSP; fully implemented in 2005) were extracted from population-based cancer registries. The patients were classified into four groups based on socioeconomic status (SES), as determined using their National Health Insurance (NHI) monthly premium at the time of cancer diagnosis...
March 6, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28277887/rnai-high-throughput-screening-of-single-and-multi-cell-type-tumor-spheroids-a-comprehensive-analysis-in-two-and-three-dimensions
#17
Jiaqi Fu, Daniel Fernandez, Marc Ferrer, Steven A Titus, Eugen Buehler, Madhu A Lal-Nag
The widespread use of two-dimensional (2D) monolayer cultures for high-throughput screening (HTS) to identify targets in drug discovery has led to attrition in the number of drug targets being validated. Solid tumors are complex, aberrantly growing microenvironments that harness structural components from stroma, nutrients fed through vasculature, and immunosuppressive factors. Increasing evidence of stromally-derived signaling broadens the complexity of our understanding of the tumor microenvironment while stressing the importance of developing better models that reflect these interactions...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28277607/identification-of-a-functional-polymorphism-affecting-microrna-binding-in-the-susceptibility-locus-1q25-3-for-colorectal-cancer
#18
Juntao Ke, Jianbo Tian, Jiaoyuan Li, Yajie Gong, Yang Yang, Ying Zhu, Yi Zhang, Rong Zhong, Jiang Chang, Jing Gong
Genome-wide association studies (GWASs) have identified dozens of susceptibility loci for colorectal cancer (CRC). However, most of them lack functional genetic variants and clear biological mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs involved in a variety of physiological and tumorigenic processes. Here we hypothesized that single nucleotide polymorphisms (SNPs) that affect miRNAs biogenesis and binding, could contribute to CRC risk in the Chinese population. To locate miRNA-related SNPs in established GWAS loci, we initially screened out five candidate SNPs using a systematic bioinformatics analysis...
March 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28277492/polyp-resection-controversial-practices-and-unanswered-questions
#19
Daniel von Renteln, Heiko Pohl
Detection and complete removal of precancerous neoplastic polyps are central to effective colorectal cancer screening. The prevalence of neoplastic polyps in the screening population in the United States is likely >50%. However, most persons with neoplastic polyps are never destined to develop cancer, and do not benefit for finding and removing polyps, and may only be harmed by the procedure. Further 70-80% of polyps are diminutive (≤5 mm) and such polyps almost never contain cancer. Given the questionable benefit, the high-cost and the potential risk changing our approach to the management of diminutive polyps is currently debated...
March 9, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28277021/the-chinese-and-korean-american-immigrant-experience-a-mixed-methods-examination-of-facilitators-and-barriers-of-colorectal-cancer-screening
#20
Mary Y Jung, Cheryl L Holt, Diane Ng, Hwa J Sim, Xiaoxiao Lu, Daisy Le, Hee-Soon Juon, Jun Li, Sunmin Lee
OBJECTIVE: Among Asian Americans, colorectal cancer (CRC) is the second leading cause of cancer deaths. Despite strong evidence that screening can reduce CRC-related mortality, fewer Chinese and Koreans receive screening as compared to non-Hispanic whites and blacks. The objective of this study was to examine facilitators and barriers as well as strategies to promote CRC screening in this population. DESIGN: This study employed a mixed-methods design. We conducted 17 key informant interviews and 12 focus groups in the Washington, D...
February 25, 2017: Ethnicity & Health
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