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JOURNAL ARTICLE
Tong Wang, Botao Gao, Zhou Yu, Baoqiang Song
OBJECTIVE: To summarize the research progress of surgical technique and immunosuppressive regimen of abdominal wall vascularized composite allograft transplantation in animals and clinical practice. METHODS: The literature on abdominal wall transplantation at home and abroad in recent years was extensively reviewed and analyzed. RESULTS: This review includes animal and clinical studies. In animal studies, partial or total full-thickness abdominal wall transplantation models have been successfully established by researchers...
July 15, 2023: Chinese Journal of Reparative and Reconstructive Surgery
#22
REVIEW
Mohamed Maklad, George Mazariegos, Armando Ganoza
PURPOSE OF REVIEW: Intestinal and multivisceral transplantation (ITx, MVTx) is the cornerstone in treatment of irreversible intestinal failure (IF) and complications related to parenteral nutrition. This review aims to highlight the unique aspects of the subject in pediatrics. RECENT FINDINGS: Etiology of intestinal failure (IF) in children shares some similarity with adults but several unique considerations when being evaluated for transplantation will be discussed...
August 1, 2023: Current Opinion in Organ Transplantation
#23
JOURNAL ARTICLE
B J Moran
John Hunter is regarded as the father of scientific surgery. His principles involved reasoning, observation and experimentation. His most powerful saying was: "Why not try the experiment?" This manuscript charts a career in abdominal surgery ranging from the treatment of appendicitis to the development of the largest appendiceal tumour centre in the world. The journey has led to the first report of a successful multivisceral and abdominal wall transplant for patients with recurrent non-resectable pseudomyxoma peritonei...
June 27, 2023: Annals of the Royal College of Surgeons of England
#24
JOURNAL ARTICLE
Shao Jin Ong, Lisa M Sharkey, Kai En Low, Heok K Cheow, Andrew J Butler, John R Buscombe
Multivisceral transplant (MVTx) refers to a composite graft from a cadaveric donor, which often includes the liver, the pancreaticoduodenal complex, and small intestine transplanted en bloc. It remains rare and is performed in specialist centres. Post-transplant complications are reported at a higher rate in multivisceral transplants because of the high levels of immunosuppression used to prevent rejection of the highly immunogenic intestine. In this study, we analyzed the clinical utility of 28 18 F-FDG PET/CT scans in 20 multivisceral transplant recipients in whom previous non-functional imaging was deemed clinically inconclusive...
June 7, 2023: Journal of Imaging
#25
JOURNAL ARTICLE
Flavio Henrique Ferreira Galvao, Jun Araki, Ana Bruna Salles Fonseca, Ruy Jorge Cruz, Cinthia Lanchotte, Daniel Reis Waisberg, Eleazar Chaib, Lucas Souto Nacif, Maria Clara de Camargo Traldi, Estrella Bianco de Mello, Wellington Andraus, Luiz Carneiro-D'Albuquerque
BACKGROUND: Multivisceral transplantation of pelvic organs would be a potential treatment for severe pelvic floor dysfunction with fecal and urinary incontinence, extensive perineal trauma, or congenital disorders. Here, we describe the microsurgical technique of multivisceral transplantation of pelvic organs, including the pelvic floor, in rats. DONOR OPERATION: We performed a perineal (including the genitalia, anus, muscles, and ligaments) and abdominal incision...
2023: Frontiers in Surgery
#26
JOURNAL ARTICLE
F Hernández Oliveros, A Alcolea Sánchez, E Ramos Boluda, A Andrés Moreno
No abstract text is available yet for this article.
April 1, 2023: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
#27
JOURNAL ARTICLE
Murilo Augusto Ferreira, Lucas Ferreira Fagundes Ouverney, Mariana Curceli Figueiredo, André Ibrahim David
BACKGROUND: Intestinal transplantation (IT) and multivisceral transplantation (MVT) are curative therapies for patients with intestinal failure and severe complications associated with total parenteral nutrition. High levels of immunosuppression are required to prevent acute cellular rejection (ACR) from the bowel. Studies regarding pre-treatment, induction, and post-transplant therapy have improved graft acceptance, reducing immunosuppression doses and infectious complications. However, the low rate of IT and MVT and the small number of specialized centers have resulted in a limited number of evidence-based immunosuppression protocols...
April 21, 2023: Transplantation Proceedings
#28
REVIEW
Shunji Nagai
PURPOSE OF REVIEW: Neuroendocrine tumor (NET) liver metastatic lesions are often multiple and found to be unresectable. Rationale of multivisceral transplantation (MVT: liver-pancreas-intestine transplantation) include radical and complete resection of primary, visible and invisible metastatic tumors by removing all abdominal organs and the lymphatic system. This review aims to describe the concept of MVT for NET and neuroendocrine liver metastasis (NELM), patient selection, timing of MVT, and posttransplant outcomes and management...
June 1, 2023: Current Opinion in Organ Transplantation
#29
JOURNAL ARTICLE
Emily E Currier, Yervant Ichkanian, Mohamad Dabaja, Maria Cristina Segovia, Yuval Patel, Shunji Nagai, Debra L Sudan, Syed-Mohammed Jafri
Intestinal transplant and multivisceral transplant were originally in pediatric populations and are relatively new procedures in adults. Despite increasing success rates in the immediate post-transplant period, infectious complications and acute and chronic rejection remain significant causes of morbidity and mortality. Previous research has shown cytomegalovirus (CMV) is the main cause of infection in this population. Due to the limited patient population, incidence of CMV viremia ranges widely and there is lack of universal protocol for treatment...
February 13, 2023: Transplantation Proceedings
#30
REVIEW
Emil Bluhme, Ewa Henckel, Carl Jorns
Organ transplantation is limited by access to suitable organs. Infant recipient waitlist mortality is increased due to the scarcity of size-matched organs. Neonatal organ donors have been proposed as an underutilized source of donor organs. However, the literature on the actual prevalence and outcome of neonatal organ donation and transplantation is fragmented and not well analyzed. This literature review aims to summarize the available literature on the potential of neonatal organ donation and to analyze published cases of neonatal organ transplantation...
February 15, 2023: Pediatric Transplantation
#31
REVIEW
Aude Van Oosterwyck, Nathalie Lauwers, Nelle Pauwels, Tim Vanuytsel
PURPOSE OF REVIEW: Intestinal transplantation (ITx), whether isolated or combined with other organs, is now a valid treatment option in some patients with chronic intestinal failure or extensive venous mesenteric thrombosis. The aim in these patients is not only to restore nutritional autonomy, but also to minimize the risk of complications, both short and long term. Despite parenteral nutrition playing a central part in the management of intestinal failure patients, there are little data about the perioperative and postoperative nutritional management of ITx patients, due to small patient populations per centre...
March 1, 2023: Current Opinion in Clinical Nutrition and Metabolic Care
#32
Ane M Andres, Jose Luis Encinas, Alba Sánchez-Galán, Javier Serradilla Rodríguez, Karla Estefania, Rocio Gonzalez Sacristan, Alida Alcolea, Pilar Serrano, Belén Estébanez, Iñigo Velasco Leon, Paula Burgos, Alvaro Gonzalez Rocafort, Bunty Ramchandani, Belén Calderón, Cristina Verdú, Esperanza Jimenez, Paloma Talayero, Pablo Stringa, Itziar de la Peña Navarro, Esther Ramos, Francisco Hernandez Oliveros
The current shortage of pediatric multivisceral donors accounts for the long time and mortality on the waiting list of pediatric patients. The use of donors after cardiac death, especially after the outbreak of normothermic regional perfusion, has increased in recent years for all solid organs except the intestine, mainly because of its higher susceptibility to ischemia-reperfusion injury. We present the first literature case of multivisceral donors after cardiac death transplantation in a 13-month-old recipient from a 2...
January 5, 2023: American Journal of Transplantation
#33
JOURNAL ARTICLE
Pablo Stringa, Leandro Emmanuel Vecchio Dezillio, Paloma Talayero, Javier Serradilla, Agustina Errea, Mariana Machuca, Rodrigo Papa-Gobbi, Onys Camps Ortega, Melisa Pucci Molineris, Natalia Lausada, Ane Miren Andres Moreno, Martin Rumbo, Francisco Hernández Oliveros
There is an urgent need to address the shortage of potential multivisceral grafts in order to reduce the average time in waiting list. Since donation after circulatory death (DCD) has been successfully employed for other solid organs, a thorough evaluation of the use of intestinal grafts from DCD is warranted. Here, we have generated a model of Maastricht III DCD in rodents, focusing on the viability of intestinal and multivisceral grafts at five (DCD5) and twenty (DCD20) minutes of cardiac arrest compared to living and brain death donors...
2023: Transplant International
#34
MULTICENTER STUDY
Yiliam Fundora, Amelia J Hessheimer, Luca Del Prete, Lorenzo Maroni, Jacopo Lanari, Oriana Barrios, Mathias Clarysse, Mikel Gastaca, Manuel Barrera Gómez, Agnès Bonadona, Julius Janek, Andrea Boscà, Jose María Álamo Martínez, Gabriel Zozaya, Dolores López Garnica, Paolo Magistri, Francisco León, Giulia Magini, Damiano Patrono, Jiří Ničovský, Abdul Rahman Hakeem, Silvio Nadalin, Lucas McCormack, Pilar Palacios, Krzysztof Zieniewicz, Gerardo Blanco, Javier Nuño, Baltasar Pérez Saborido, Juan Echeverri, J Steve Bynon, Paulo N Martins, Víctor López López, Murat Dayangac, J Peter A Lodge, Renato Romagnoli, Christian Toso, Julio Santoyo, Fabrizio Di Benedetto, Concepción Gómez-Gavara, Fernando Rotellar, Miguel Ángel Gómez-Bravo, Rafael López Andújar, Edouard Girard, Andrés Valdivieso, Jacques Pirenne, Laura Lladó, Giacomo Germani, Matteo Cescon, Koji Hashimoto, Cristiano Quintini, Umberto Cillo, Wojciech G Polak, Constantino Fondevila
BACKGROUND & AIMS: Complex portal vein thrombosis (PVT) is a challenge in liver transplantation (LT). Extra-anatomical approaches to portal revascularization, including renoportal (RPA), left gastric vein (LGA), pericholedochal vein (PCA), and cavoportal (CPA) anastomoses, have been described in case reports and series. The RP4LT Collaborative was created to record cases of alternative portal revascularization performed for complex PVT. METHODS: An international, observational web registry was launched in 2020...
April 2023: Journal of Hepatology
#35
Lisa Remaley, Chethan Ashokkumar, Kyle A Soltys, George Vincent Mazariegos, Geoffrey James Bond, Ajai Khanna, Armando Ganoza, Miguel Reyes-Mugica, Adriana Zeevi, Rakesh Sindhi
BACKGROUND: Operational tolerance after retransplantation of the intestine has never been reported. PURPOSE: To two recently described intestine transplant recipients with operational tolerance, we now add a third. METHODS: Review of case record and immunological testing to confirm donor-specific hyporesponsiveness in multiple immune cell compartments. RESULTS: Re-transplanted with a multivisceral liver- and kidney-inclusive intestine allograft at age 12 years, this recipient self-discontinued immunosuppression 14 years after the retransplant and has been rejection free for 2 years thereafter...
December 18, 2022: Pediatric Transplantation
#36
JOURNAL ARTICLE
Iago Justo, Clara Fernández, Óscar Caso, Alberto Marcacuzco, Alejandro Manrique, Jorge Calvo, Álvaro García-Sesma, Cristina Rivas, Félix Cambra, Carmelo Loinaz, Carlos Jiménez-Romero
BACKGROUND: Twenty percent of intestinal transplant recipients will require a surgical alternative to conventional primary abdominal wall closure. Abdominal wall transplant is a developing technique that is increasingly performed for this purpose in isolated intestinal or multivisceral recipients; however, adequate closure of the donor is paramount while simultaneously obtaining a large enough graft. The aim of this study is to describe alternative surgical techniques for closure of the donor in cases in which abdominal wall graft extraction hinders subsequent donor abdominal closure...
October 20, 2022: Transplantation Proceedings
#37
JOURNAL ARTICLE
Yeh-Chung Chang, Rebecca R Young, Alisha M Mavis, Eileen T Chambers, Sonya Kirmani, Matthew S Kelly, Ibukunoluwa C Kalu, Michael J Smith, Debra J Lugo
BACKGROUND: Pediatric solid organ transplant (SOT) recipients commonly have Epstein-Barr virus (EBV) DNAemia and are at risk of developing post-transplant lymphoproliferative disorder (PTLD). EBV DNAemia has not been analyzed on a continuous scale in this population. METHODS: All children ≤ 18 years of age who underwent SOT at a single center between January 1, 2007 and July 31, 2018 were included in this retrospective study. Transplant episodes in which PTLD occurred were compared to transplant episodes without PTLD...
2022: PloS One
#38
JOURNAL ARTICLE
Sage B Greenlee, Tommy J Parraga Acosta, Charles T Makowski, Rachel M Kenney, Mayur Ramesh, Jonathan D Williams, George J Alangaden
BACKGROUND: This study seeks to describe inpatient antimicrobial use (AU) utilizing the National Healthcare Safety Network-AU (NHSN-AU) framework among solid organ transplant recipients (SOTr) within 12 months after transplant. METHODS: This cross-sectional study included SOTr ≥ 18 years of age who underwent transplantation from January 2015 to December 2016 at a Midwestern US transplant center. Inpatient AU was followed for 12 months post-transplant. Hospital days present up to 12 months post-transplant, AU variables, and Clostridioides difficile infection (CDI) occurrences were analyzed...
October 2022: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#39
JOURNAL ARTICLE
Gianni Testino, Rinaldo Pellicano, Fabio Caputo
BACKGROUND: In the present experience we have evaluated the link alcohol consumption/alcohol use disorder (AUD) and organ transplantation (OT) in order to provide adequate suggestions. METHODS: The data used for the preparation of these recommendations are based on a detailed analysis of the scientific literature published before August 31, 2022 (Web of Science, Scopus, Google Scholar). Furthermore, in the process of developing this work, we consulted the guidelines / position papers of the scientific societies...
October 12, 2022: Minerva gastroenterology
#40
JOURNAL ARTICLE
Laura T Reed, Scott R Echternacht, Kumaran Shanmugarajah, Roberto Hernandez, Howard N Langstein, Jonathan I Leckenby
BACKGROUND: Abdominal wall allotransplantation following intestinal and multivisceral transplant procedures has proven to be successful in achieving adequate closure in patients in whom other techniques have proven inadequate. Thus far, the focus of these abdominal wall allotransplants has been on graft and overall patient survival following surgery and the implementation of immunosuppression. The purpose of this study was to review the outcomes of abdominal wall allotransplantation reported in the literature...
November 1, 2022: Plastic and Reconstructive Surgery
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