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https://www.readbyqxmd.com/read/28637339/emergence-of-ceftazidime-avibactam-non-susceptibility-in-an-mdr-klebsiella-pneumoniae-isolate
#1
Anna Both, Henning Büttner, Jiabin Huang, Markus Perbandt, Cristina Belmar Campos, Martin Christner, Florian P Maurer, Stefan Kluge, Christina König, Martin Aepfelbacher, Dominic Wichmann, Holger Rohde
Background: Avibactam is a novel broad-range β-lactamase inhibitor active against Ambler class A (including ESBL and KPC) and some Ambler class C and D (e.g. OXA-48) enzymes. We here report on the emergence of ceftazidime/avibactam resistance in clinical, multiresistant, OXA-48 and CTX-M-14-producing Klebsiella pneumoniae isolate DT12 during ceftazidime/avibactam treatment. Methods and results: Comparative whole-genome sequence analysis identified two SNPs in the CTX-M-14-encoding gene leading to two amino acid changes (P170S and T264I)...
June 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28637209/purification-and-characterization-of-two-new-cell-bound-bioactive-compounds-produced-by-wildlactococcus-lactisstrain
#2
Margarete Alice Fontes Saraiva, Dag Anders Brede, Ingolf Figved Nes, Maria Cristina Baracat-Pereira, Marisa Vieira de Queiroz, Célia Alencar de Moraes
Novel compounds and innovative methods are required considering that antibiotic resistance has reached a crisis point. In the study, two cell-bound antimicrobial compounds produced by L. lactis ID1.5 were isolated and partially characterized. Following purification by cationic exchange and a solid phase C18 column, antimicrobial activity was recovered after three runs of RPC using 60% (v/v) and 100% (v/v) of 2-propanol for elution, suggesting that more than one antimicrobial compound were produced by L. lactis ID1...
June 20, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28637186/cpg-and-methylation-dependent-dna-binding-and-dynamics-of-the-methylcytosine-binding-domain-2-protein-at-the-single-molecule-level
#3
Hai Pan, Stephanie M Bilinovich, Parminder Kaur, Robert Riehn, Hong Wang, David C Williams
The methylcytosine-binding domain 2 (MBD2) protein recruits the nucleosome remodeling and deacetylase complex (NuRD) to methylated DNA to modify chromatin and regulate transcription. Importantly, MBD2 functions within CpG islands that contain 100s to 1000s of potential binding sites. Since NuRD physically rearranges nucleosomes, the dynamic mobility of this complex is directly related to function. In these studies, we use NMR and single-molecule atomic force microscopy and fluorescence imaging to study DNA binding dynamics of MBD2...
June 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28637173/crystallographic-analyses-illustrate-significant-plasticity-and-efficient-recoding-of-meganuclease-target-specificity
#4
Rachel Werther, Jazmine P Hallinan, Abigail R Lambert, Kyle Havens, Mark Pogson, Jordan Jarjour, Roberto Galizi, Nikolai Windbichler, Andrea Crisanti, Tony Nolan, Barry L Stoddard
The retargeting of protein-DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging. Here, we describe structural analyses of five different extensively retargeted variants of a single homing endonuclease, that have been shown to function efficiently in ex vivo and in vivo applications. The redesigned proteins harbor mutations at up to 53 residues (18%) of their amino acid sequence, primarily distributed across the DNA binding surface, making them among the most significantly reengineered ligand-binding proteins to date...
June 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28637094/acclimation-responses-to-high-light-by-guazuma-ulmifolia-lam-malvaceae-leaves-at-different-stages-of-development
#5
Anderson Kikuchi Calzavara, Juliana Silva Rocha, Geovana Lourenço, Karina Sanada, Cristiano Medri, Edmilson Bianchini, José Antonio Pimenta, Renata Stolf-Moreira, Halley Caixeta Oliveira
The recomposition of deforested environments requires the prior acclimation of seedlings to full sun in nurseries. Seedlings can overcome excessive light either through the acclimation of pre-existing fully expanded leaves or through the development of new leaves that are acclimated to the new light environment. Here, we compared the acclimation capacity of mature (MatL, fully expanded at the time of transfer) and newly expanded leaves (NewL, expanded after the light shift) of Guazuma ulmifolia Lam. (Malvaceae) seedlings to high light...
June 21, 2017: Plant Biology
https://www.readbyqxmd.com/read/28636822/electrochemical-properties-and-speciation-in-mg-hmds-2-based-electrolytes-for-magnesium-ion-batteries-as-a-function-of-ethereal-solvent-type-and-temperature
#6
Laura C Merrill, Jennifer L Schaefer
Magnesium batteries are a promising alternative to lithium-ion batteries due to the widespread abundance of magnesium and its high specific volumetric energy capacity. Ethereal solvents such as tetrahydrofuran (THF) are commonly used for magnesium-ion electrolytes due the chemical compatibility with magnesium metal, but the volatile nature of THF is a concern for practical application. Herein, we investigate magnesium bis(hexamethyldisilazide) plus aluminum chloride (Mg(HMDS)2-AlCl3) electrolytes in THF, diglyme, and tetraglyme at varying temperature...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28636444/a-highly-infectious-disease-care-network-in-the-us-healthcare-system
#7
Aurora B Le, Paul D Biddinger, Philip W Smith, Jocelyn J Herstein, Deborah A Levy, Shawn G Gibbs, John J Lowe
During the 2014-15 Ebola outbreak in West Africa, the United States responded by stratifying hospitals into 1 of 3 Centers for Disease Control and Prevention (CDC)-designated categories-based on the hospital's ability to identify, isolate, assess, and provide care to patients with suspected or confirmed Ebola virus disease (EVD)-in an attempt to position the US healthcare system to safely isolate and care for potential patients. Now, with the Ebola epidemic quelled, it is crucial that we act on the lessons learned from the EVD response to broaden our national perspective on infectious disease mitigation and management, build on our newly enhanced healthcare capabilities to respond to infectious disease threats, develop a more cost-effective and sustainable model of infectious disease prevention, and continue to foster training so that the nation is not in a vulnerable position once more...
May 2017: Health Security
https://www.readbyqxmd.com/read/28636376/on-the-mechanism-of-the-iodide-triiodide-exchange-reaction-in-a-solid-state-ionic-liquid
#8
Joás Grossi, Jorge J Kohanoff, Niall J English, Eduardo M Bringa, Mario G Del Pópolo
Efficient charge transport has been observed in iodide-based room-temperature ionic liquids when doped with iodine. To investigate preferred pathways for the iodide (I(-))-to-triiodide (I3(-)) exchange reaction and to clarify the origin of this high ionic conductivity, we have conducted electronic structure calculations in the crystal state of 1-butyl-3-methylimidazolium iodide ([BMIM][I]). Energy barriers for the different stages of the iodine-swapping process, including the reorientation of the I(-)···I3(-) moiety, were determined from minimum energy paths as a function of a reaction coordinate...
June 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28636369/dynamics-of-charged-species-in-ionic-neutral-block-copolymer-and-surfactant-complexes
#9
Jose M Borreguero, Philip A Pincus, Bobby G Sumpter, Monojoy Goswami
Structure-property relationships of ionic block copolymer (BCP) surfactant complexes are critical towards the progress of favorable engineering design of efficient charge transport materials. In this article, molecular dynamics simulations are used to understand the dynamics of charge-neutral BCP and surfactant complexes. The dynamics are examined for two different systems, charged-neutral double hydrophilic and hydrophobic-hydrophilic block copolymers with oppositely charged surfactant moieties. The dynamics of the surfactant head, tails and charges are studied for five different BCP volume fractions...
June 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28636347/the-structure-and-dynamics-of-alginate-gels-crosslinked-by-polyvalent-ions-probed-via-solid-state-nmr-spectroscopy
#10
Jiří Brus, Martina Urbanová, Jiri Czernek, Miroslava Pavelkova, Katerina Kubova, Jakub Vyslouzil, Sabina Abbrent, Rafal Konefal, Jiri Horsky, David Vetchy, Jan Vysloužil, Pavel Kulich
Alginate gels are an outstanding biomaterial widely applicable in tissue engineering, medicine, and pharmacy for cell transplantation, wound healing and efficient bioactive agent delivery, respectively. This contribution provides new and comprehensive insight into the atomic-resolution structure and dynamics of polyvalent ion-crosslinked alginate gels in microbead formulations. By applying various advanced solid-state NMR (ssNMR) spectroscopy techniques, we verified the homogenous distribution of the crosslinking ions in the alginate gels and the high degree of ion exchange...
June 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28636155/the-use-of-transnasal-humidified-rapid-insufflation-ventilatory-exchange-thrive-in-17-cases-of-subglottic-stenosis
#11
Kim To, Fleur Harding, McNeill Scott, Pamela Milligan, Iain J Nixon, Richard Adamson, Alistair F McNarry
Shared airway management in patients with subglottic stenosis (SGS) is challenging for both the anaesthetist and surgeon. Various methods of airway management have been described but currently no gold standard exists. Jet ventilation has been described as the preferred technique despite a UK National Survey highlighting potential complications including pneumothorax, pneumomediastinum, surgical emphysema, hypoxia and death. This article is protected by copyright. All rights reserved.
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28636148/magneto-structural-characterization-of-oxalamide-dihalo-bridged-copper-dimers-intra-and-interdimer-interactions-studied-by-single-crystal-esr-spectroscopy
#12
Dijana Zilic, Debdeep Maity, Mario Cetina, Kresimir Molcanov, Zoran Dzolic, Mirta Herak
The detailed single crystal electron spin resonance (ESR) analysis of oxalamide complexes with halogen-bridged copper dimers, supported by X-ray, magnetic susceptibility and powder ESR studies, is reported. Four complexes with two different ligands were synthesized: [CuLA(μ-X)]₂ and [CuLV(μ-X)]₂, where LA = N-(L-alanine methyl ester)-N'-((2-pyridine-2-yl)methyl)oxalamide and LV=N-(L-valine methyl ester)-N'-((2-pyridine-2-yl)methyl)oxalamide, while X=Cl or Br. X-ray analysis shows that geometry at each copper(II) ion is square pyramidal while two pyramids share one base-to-apex edge with parallel basal planes...
June 21, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28636013/new-insights-into-the-solubility-of-graphene-oxide-in-water-and-alcohols
#13
Vadim V Neklyudov, Nail R Khafizov, Igor A Sedov, Ayrat M Dimiev
One of the main advantages of graphene oxide (GO) over its non-oxidized counterpart is its ability to form stable solutions in water and some organic solvents. At the same time, the nature of GO solutions is not completely understood; the existing data are scarce and controversial. Here, we demonstrate that the solubility of GO, and the stability of the as-formed solutions depend not just on the solute and solvent cohesion parameters, as commonly believed, but mostly on the chemical interactions at the GO/solvent interface...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28635961/hypoxia-induced-mobilization-of-nhe6-to-the-plasma-membrane-triggers-endosome-hyperacidification-and-chemoresistance
#14
Fabrice Lucien, Pierre-Paul Pelletier, Roxane R Lavoie, Jean-Michel Lacroix, Sébastien Roy, Jean-Luc Parent, Dominique Arsenault, Kelly Harper, Claire M Dubois
The pH-dependent partitioning of chemotherapeutic drugs is a fundamental yet understudied drug distribution mechanism that may underlie the low success rates of current approaches to counter multidrug resistance (MDR). This mechanism is influenced by the hypoxic tumour microenvironment and results in selective trapping of weakly basic drugs into acidified compartments such as the extracellular environment. Here we report that hypoxia not only leads to acidification of the tumour microenvironment but also induces endosome hyperacidification...
June 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28635621/the-charge-and-spin-transport-properties-in-hexagonal-silicene-nanorings
#15
Ning Xu, Haiyang Zhang, Xiuqiang Wu, Chen Qiao, Jian-Wen Ding
Based on the tight-binding model, charge and spin transport properties of hexagonal silicene rings are investigated within the nonequilibrium Green's function technique. The effects of external electric, magnetic and exchange fields are taken into account. The calculated results reveal that the hexagonal silicene nanorings act as a controllable spin filter. The near-perfect spin polarization can be achieved by adjusting electric, magnetic and exchange fields. The calculated results offer new possibilities for silicene ring based spin nanodevices...
June 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28635356/simultaneous-abo-incompatible-living-donor-liver-transplantation-and-splenectomy-without-plasma-exchange-in-china-two-case-reports
#16
Guoyong Chen, Janjun Sun, Sidong Wei, Yongfeng Chen, Gaofeng Tang, Zhantao Xie, Huaen Xu, Janbin Chen, Huibo Zhao, Zhenhua Yuan, Weiwei Wang, Guangbo Liu, Bing Wang, Biao Niu
ABO-incompatible (ABO-i) living-donor liver transplantation (LDLT) is performed if an ABO-compatible graft cannot be obtained. However, a perfect desensitization protocol has not been established worldwide, especially for simultaneous ABO-i LDLT and splenectomy. We herein report two cases of ABO-i LDLT. To the best of our knowledge, this is the first case report of ABO-i LDLT in an adult patient in China. Splenectomy and T-cell-targeted immunosuppression (basiliximab) was used to overcome the blood group barrier in these recipients...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28635255/characterization-and-immunomodulatory-activity-of-a-novel-peptide-ecfsta-from-wheat-germ-globulin
#17
Wenjia Wu, Mengmeng Zhang, Yao Ren, Xinze Cai, Zhina Yin, Xiaoai Zhang, Tian Min, Hui Wu
A novel peptide was extracted from wheat germ globulin and purified using ion-exchange chromatography, gel filtration chromatography and semi-preparative reverse phase-high performance liquid chromatography (RP-HPLC). The sequence of the peptide was found to be Glu-Cys-Phe-Ser-Thr-Ala (ECFSTA). Its immunomodulatory effects were evaluated, and the results showed that ECFSTA could enhance phagocytosis of RAW 264.7 cells and significantly increase their secretion of nitric oxide (NO), interleukins-6 (IL-6), tumor necrosis factors-α (TNF-α), and reactive oxygen species (ROS)...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28634802/alkaline-treated-sawdust-as-an-effective-material-for-cationic-dye-removal-from-textile-effluents-under-dynamic-conditions-breakthrough-curve-prediction-and-mechanism-exploration
#18
Ahmed Amine Azzaz, Salah Jellali, Rahma Souissi, Karim Ergaieg, Latifa Bousselmi
This paper deals with the methylene blue molecule (MB) removal from synthetic and real textile wastewaters by alkali-treated orange tree sawdust (ATOS) under different dynamic conditions. Experimental results showed that MB removal efficiencies by ATOS increased when increasing initial dye concentrations and bed depths but decreased with the increase of the applied flow rates with a maximum adsorption capacity of about 110 mg g(-1). Moreover, various empirical models were applied to predict the experimental breakthrough curves (BTCs) and to determine the characteristic adsorption parameters...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634801/ameliorating-soil-acidity-and-physical-properties-of-two-contrasting-texture-ultisols-with-wastewater-sludge-biochar
#19
Yutong Zong, Yefeng Wang, Ye Sheng, Chengfeng Wu, Shenggao Lu
The production of biochar is a safe and beneficial disposal way for wastewater sludge. The biochar produced from wastewater sludge can be used as soil amendments for improving soil properties and for increasing crop yield. This work investigated the influences of wastewater sludge biochar (WSB) on the pH, exchangeable acidity, and physical properties of strongly acidic Ultisols with contrasting texture (clayey soil and sandy loam). Two soils were mixed with WSB at the rate of 0, 10, 20, and 40 g biochar kg(-1) soil and incubated for 240 days at 75% field water capacity...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634798/value-of-biochars-from-miscanthus-x-giganteus-cultivated-on-contaminated-soils-to-decrease-the-availability-of-metals-in-multicontaminated-aqueous-solutions
#20
Adeline Janus, Aurélie Pelfrêne, Karin Sahmer, Sophie Heymans, Christophe Deboffe, Francis Douay, Christophe Waterlot
The objective of this study was to evaluate the sorption efficiency of eight biochars, made from Miscanthus x giganteus cultivated on contaminated agricultural soil, in aqueous solutions contaminated with metals alone or mixed with polycyclic aromatic hydrocarbons. These biochars were produced in different pyrolysis conditions (temperature, 400/600 °C; heating rate, 5/10 °C min(-1); duration, 45/90 min) and compared with an uncontaminated commercialized biochar made of wood. The physicochemical characterization of the Miscanthus biochars confirmed the impact of the pyrolysis on the biochar parameters with substantial differences between the biochars in terms of pH, cation exchange capacity, and specific surface area...
June 20, 2017: Environmental Science and Pollution Research International
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