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https://www.readbyqxmd.com/read/28110498/neutral-losses-of-sodium-benzoate-and-benzoic-acid-in-the-fragmentation-of-the-m%C3%A2-%C3%A2-na-ions-of-methoxyfenozide-and-tebufenozide-via-intramolecular-rearrangement-in-electrospray-ionization-tandem-mass-spectrometry
#1
Yunfeng Chai, Guanwei Gao, Shanshan Shen, Xin Liu, Chengyin Lu
RATIONALE: Electrospray ionization (ESI) tandem mass spectrometry can be applied to determine structural information about organic compounds. The [M + Na](+) ion is one of the major precursor ions in ESI mass spectrometry, but its fragmentation mechanism study is still insufficient. This study reveals the interesting fragmentation reactions of the [M + Na](+) ions of methoxyfenozide and tebufenozide. METHODS: The fragmentations of the [M + Na](+) , [M + Li](+) , and [M + H](+) ions of methoxyfenozide and tebufenozide were studied using a hybrid quadrupole-orbitrap mass spectrometer and an ion trap mass spectrometer...
February 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28110486/spectra-optia-%C3%A2-for-automated-red-blood-cell-exchange-in-patients-with-sickle-cell-disease-a-nice-medical-technology-guidance
#2
REVIEW
Iain Willits, Helen Cole, Roseanne Jones, Kimberley Carter, Mick Arber, Michelle Jenks, Joyce Craig, Andrew Sims
The Spectra Optia(®) automated apheresis system, indicated for red blood cell exchange in people with sickle cell disease, underwent evaluation by the National Institute for Health and Care Excellence, which uses its Medical Technologies Advisory Committee to make recommendations. The company (Terumo Medical Corporation) produced a submission making a case for adoption of its technology, which was critiqued by the Newcastle and York external assessment centre. Thirty retrospective observational studies were identified in their clinical submission...
January 21, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28110276/photosynthesis-in-c3-c4-intermediate-moricandia-species
#3
Urte Schlüter, Andrea Bräutigam, Udo Gowik, Michael Melzer, Pascal-Antoine Christin, Samantha Kurz, Tabea Mettler-Altmann, Andreas Pm Weber
Evolution of C4 photosynthesis is not distributed evenly in the plant kingdom. Particularly interesting is the situation in the Brassicaceae, because the family contains no C4 species, but several C3-C4 intermediates, mainly in the genus Moricandia Investigation of leaf anatomy, gas exchange parameters, the metabolome, and the transcriptome of two C3-C4 intermediate Moricandia species, M. arvensis and M. suffruticosa, and their close C3 relative M. moricandioides enabled us to unravel the specific C3-C4 characteristics in these Moricandia lines...
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28110234/effect-of-ethylenediamine-n-n-disuccinic-acid-edds-on-the-speciation-and-bioavailability-of-fe-2-in-the-presence-of-sulfide-in-anaerobic-digestion
#4
Pham Minh Thanh, Balachandran Ketheesan, Zhou Yan, David Stuckey
The effects of a biodegradable chelating agent, Ethylenediamine-N,N'-disuccinic acid (EDDS), on the speciation and bioavailability of iron (Fe(2+)) in anaerobic digestion were examined. Fe(2+) supplementation at 10mg/L increased methane yield, but the presence of 8mg/L sulfide led to the precipitation of Fe(2+) as FeS which limited its bioavailability. The results confirmed that the EDDS could replace common chelating agents with low biodegradability (EDTA and NTA), and improve the bioavailability of Fe(2+) by forming an Fe-EDDS complex, thereby protecting Fe(2+) from sulfide precipitation...
January 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28110198/variation-of-atmospheric-14-co2-and-its-spatial-distribution
#5
Shugang Wu
The atmospheric (14)CO2 is usually presented in the Δ(14)C notation, which cannot reflect its absolute quantity change. This article presents the atmospheric radiocarbon activity concentrations (aacn, reported in mBq/m(3)) in recent years at nine observation stations. The aacn at Schauinsland decrease from 1977 to 1993 but between 1993 and 2003 keeps at a relative steady state. Atmospheric aacns were higher in the northern hemisphere than that in the southern hemisphere. The aacns in the northern hemisphere show clear seasonal cycle with higher value in winter and lower value in summer, while this seasonality is not obvious in the southern hemisphere...
January 19, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28110161/citrate-and-albumin-facilitate-transferrin-iron-loading-in-the-presence-of-phosphate
#6
Catalina Matias, Devin W Belnap, Michael T Smith, Michael G Stewart, Isaac F Torres, Andrew J Gross, Richard K Watt
Labile plasma iron (LPI) is redox active, exchangeable iron that catalyzes the formation of reactive oxygen species. Serum transferrin binds iron in a non-exchangeable form and delivers iron to cells. In several inflammatory diseases serum LPI increases but the reason LPI forms is unknown. This work evaluates possible pathways leading to LPI and examines potential mediators of apo transferrin iron loading to prevent LPI. Previously phosphate was shown to inhibit iron loading into apo transferrin by competitively binding free Fe(3+)...
December 11, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28109901/study-of-ciprofloxacin-adsorption-and-regeneration-of-activated-carbon-prepared-from-enteromorpha-prolifera-impregnated-with-h3po4-and-sodium-benzenesulfonate
#7
Man Wang, Gang Li, Lihui Huang, Jing Xue, Quan Liu, Nan Bao, Ji Huang
Activated carbons were derived from Enteromorpha prolifera immersed in H3PO4 solution or the H3PO4 solution mixed with sodium benzenesulfonate (SBS), producing AC and AC-SBS. NaOH solution was employed in regeneration of ciprofloxacin (CIP)-loaded AC and AC-SBS to obtain RAC and RAC-SBS. The properties of the original and regenerated activated carbons were characterized by thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM), N2 adsorption/desorption isotherms and Fourier transform infrared spectroscopy (FTIR)...
January 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28109527/functionalization-of-hybrid-monolithic-columns-via-thiol-ene-click-reaction-for-proteomics-analysis
#8
Zhongshan Liu, Jing Liu, Zheyi Liu, Hongwei Wang, Junjie Ou, Mingliang Ye, Hanfa Zou
The vinyl-functionalized hybrid monolithic columns (75 and 150μm i.d.) were prepared via sol-gel chemistry of tetramethoxysilane (TMOS) and vinyltrimethoxysilane (VTMS). The content of accessible vinyl groups was further improved after the monolithic column was post-treated with vinyldimethylethoxysilane (VDMES). The surface properties of monolithic columns were tailored via thiol-ene click reaction by using 1-octadecanethiol, sodium 3-mercapto-1-propanesulfonate and 2,2'-(ethylenedioxy)diethanethiol/vinylphosphonic acid, respectively...
January 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28109436/combining-click-chemistry-based-proteomics-with-dox-inducible-gene-expression
#9
J Gebert, M Schnölzer, U Warnken, J Kopitz
Inactivating mutations in single genes can trigger, prevent, promote, or alleviate diseases. Identifying such disease-related genes is a main pillar of medical research. Since proteins play a crucial role in mediating these effects, their impact on the diseased cells' proteome including posttranslational modifications has to be elucidated for a detailed understanding of the role of these genes in the disease process. In complex disorders, like cancer, several genes contribute to the disease process, thereby hampering the assignment of a proteomic change to the corresponding causative gene...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28109279/a-comparative-analysis-of-centralized-waiting-lists-for-patients-without-a-primary-care-provider-implemented-in-six-canadian-provinces-study-protocol
#10
Mylaine Breton, Michael Green, Sara Kreindler, Jason Sutherland, Jalila Jbilou, Sabrina T Wong, Jay Shaw, Valorie A Crooks, Damien Contandriopoulos, Mélanie Ann Smithman, Astrid Brousselle
BACKGROUND: Having a regular primary care provider (i.e., family physician or nurse practitioner) is widely considered to be a prerequisite for obtaining healthcare that is timely, accessible, continuous, comprehensive, and well-coordinated with other parts of the healthcare system. Yet, 4.6 million Canadians, approximately 15% of Canada's population, are unattached; that is, they do not have a regular primary care provider. To address the critical need for attachment, especially for more vulnerable patients, six Canadian provinces have implemented centralized waiting lists for unattached patients...
January 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28109240/microphase-separation-in-random-multiblock-copolymers
#11
E N Govorun, A V Chertovich
Microphase separation in random multiblock copolymers is studied with the mean-field theory assuming that long blocks of a copolymer are strongly segregated, whereas short blocks are able to penetrate into "alien" domains and exchange between the domains and interfacial layer. A bidisperse copolymer with blocks of only two sizes (long and short) is considered as a model of multiblock copolymers with high polydispersity in the block size. Short blocks of the copolymer play an important role in the microphase separation...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28109126/a-step-wise-approach-to-define-binding-mechanisms-of-surrogate-viral-particles-to-multi-modal-anion-exchange-resin-in-a-single-solute-system
#12
Matthew Brown, Sarah Johnson, Kurt Brorson, Scott Lute, David Roush
Multi-modal anion exchange resins combine properties of both anion exchange and hydrophobic interaction chromatography for commercial protein polishing and may provide some viral clearance as well. From a regulatory viral clearance claim standpoint, it is unclear if multi-modal resins are truly orthogonal to either single-mode anion exchange or hydrophobic interaction columns. To answer this, a strategy of solute surface assays and High Throughput Screening of resin in concert with a scale-down model of large scale chromatography purification was employed to determine the predominant binding mechanisms of a panel of bacteriophage (i...
January 21, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28108980/the-influence-of-macrophages-on-mesenchymal-stromal-cell-therapy-passive-or-aggressive-agents
#13
REVIEW
Fiona Carty, Bernard P Mahon, Karen English
Mesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date, however, recently a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to better design MSC therapies and clinical studies...
January 20, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28108962/determination-of-equine-cytochrome-c-backbone-amide-hydrogen-deuterium-exchange-rates-by-mass-spectrometry-using-a-wider-time-window-and-isotope-envelope
#14
Yoshitomo Hamuro
A new strategy to analyze amide hydrogen/deuterium exchange mass spectrometry (HDX-MS) data is proposed, utilizing a wider time window and isotope envelope analysis of each peptide. While most current scientific reports present HDX-MS data as a set of time-dependent deuteration levels of peptides, the ideal HDX-MS data presentation is a complete set of backbone amide hydrogen exchange rates. The ideal data set can provide single amide resolution, coverage of all exchange events, and the open/close ratio of each amide hydrogen in EX2 mechanism...
January 20, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28108921/heavy-metals-and-nutrients-carbon-nitrogen-and-phosphorus-in-sediments-relationships-to-land-uses-environmental-risks-and-management
#15
Yubao Li, Joselito M Arocena, Qiao Zhang, Ronald W Thring, Jianbing Li
Management of sediments in polluted rivers requires an inventory of sediment quantities as well as their nutrient and metal contents and the chemical forms of pollutants. We investigated the influence of three major land uses (i.e., orange plantation-OP, OP + residential + industrial-OPRI, and residential + industrial-RI) on the quality of surface sediments (0-20 cm below water/sediment interface) at the Sanyang Wetland (China). The total contents of metals (As, Cd, Cr, Cu, Ni, Pb, and Zn) and nutrients (C, N, and P) as well as metal speciation in sediments were examined...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28108875/against-the-odds-syringe-exchange-policy-implementation-in-indiana
#16
Beth E Meyerson, Carrie A Lawrence, Laura Miller, Anthony Gillespie, Daniel Raymond, Kristen Kelley, D J Shannon
Indiana recently passed legislation allowing local governments to establish syringe exchanges. While the effectiveness of syringe exchange programming is established, there is a dearth of studies about associated policy adoption and implementation. This study documents the experiences of 24 Indiana counties engaged in the process of establishing syringe exchange programming under new state law. A mixed method, qualitative, exploratory case study was conducted from May 2015 to April 2016. We observed rapid and widespread policy adoption interest, and yet counties reported significant policy ambiguity, epidemiologic and resource capacity issues...
January 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28108866/donor-conception-and-passing-or-why-australian-parents-of-donor-conceived-children-want-donors-who-look-like-them
#17
Karen-Anne Wong
This article explores the processes through which Australian recipients select unknown donors for use in assisted reproductive technologies and speculates on how those processes may affect the future life of the donor-conceived person. I will suggest that trust is an integral part of the exchange between donors, recipients, and gamete agencies in donor conception and heavily informs concepts of relatedness, race, ethnicity, kinship, class, and visibility. The decision to be transparent (or not) about a child's genetic parentage affects recipient parents' choices of donor, about who is allowed to "know" children's genetic backgrounds, and how important it is to be able to "pass" as an unassisted conception...
January 20, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28108829/vascular-contractile-reactivity-in-hypotension-due-to-reduced-renal-reabsorption-of-na-and-restricted-dietary-na
#18
Saeed Alshahrani, Robert M Rapoport, Manoocher Soleimani
Reduced renal Na(+) reabsorption along with restricted dietary Na(+) depletes intravascular plasma volume which can then result in hypotension. Whether hypotension occurs and the magnitude of hypotension depends in part on compensatory angiotensin II-mediated increased vascular resistance. We investigated whether the ability of vascular resistance to mitigate the hypotension was compromised by decreased contractile reactivity. In vitro reactivity was investigated in aorta from mouse models of reduced renal Na(+) reabsorption and restricted dietary Na(+) associated with considerable hypotension and renin-angiotensin system activation: (1) the Na(+)-Cl(-)-Co-transporter (NCC) knockout (KO) with Na(+) restricted diet (0...
January 20, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28108650/aerobic-efficiency-is-associated-with-the-improvement-in-maximal-power-output-during-acute-hyperoxia
#19
Tom A Manselin, Olof Södergård, Filip J Larsen, Peter Lindholm
This study investigated the relationship between aerobic efficiency during cycling exercise and the increase in physical performance with acute hyperoxic exposure (FiO2 ~31%) (HOX) and also tested the hypothesis that fat oxidation could be increased by acute hyperoxia. Fourteen males and four females were recruited for two sessions, where they exercised for 2 × 10 min at 100 W to determine efficiency. HOX and normoxia (NOX) were administered randomly on both occasions to account for differences in nitrogen exchange...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28108526/vaps-and-acbd5-tether-peroxisomes-to-the-er-for-peroxisome-maintenance-and-lipid-homeostasis
#20
Rong Hua, Derrick Cheng, Étienne Coyaud, Spencer Freeman, Erminia Di Pietro, Yuqing Wang, Adriano Vissa, Christopher M Yip, Gregory D Fairn, Nancy Braverman, John H Brumell, William S Trimble, Brian Raught, Peter K Kim
Lipid exchange between the endoplasmic reticulum (ER) and peroxisomes is necessary for the synthesis and catabolism of lipids, the trafficking of cholesterol, and peroxisome biogenesis in mammalian cells. However, how lipids are exchanged between these two organelles is not understood. In this study, we report that the ER-resident VAMP-associated proteins A and B (VAPA and VAPB) interact with the peroxisomal membrane protein acyl-CoA binding domain containing 5 (ACBD5) and that this interaction is required to tether the two organelles together, thereby facilitating the lipid exchange between them...
January 20, 2017: Journal of Cell Biology
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