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Colorectal cancer surgery

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https://www.readbyqxmd.com/read/29448304/neutrophil-lymphocyte-ratio-as-a-method-of-predicting-complications-following-hepatic-resection-for-colorectal-liver-metastasis
#1
Simon J McCluney, Alexandros Giakoustidis, Angela Segler, Juliane Bissel, Roberto Valente, Robert R Hutchins, Ajit T Abraham, Satyajit Bhattacharya, Hemant M Kocher
BACKGROUND AND OBJECTIVES: Approximately 30-50% of patients with colorectal cancer develop liver metastasis for which liver resection is the only hope for potential cure. However, hepatic resection is associated with considerable morbidity. The aim was to detect early complications by utilising the neutrophil: lymphocyte ratio (NLR). METHODS: We performed a retrospective cohort study of patients undergoing hepatic resection at a single institution between 2008 and 2016...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29447923/the-significance-of-tumor-budding-in-t1-colorectal-carcinoma-the-most-reliable-predictor-of-lymph-node-metastasis-especially-in-endoscopically-resected-t1-colorectal-carcinoma
#2
So Jeong Lee, Ahrong Kim, Young Keum Kim, Won Young Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh, Geum Am Song, Do Youn Park
Endoscopic resection is widely recognized as a first-line treatment for T1 colorectal cancers (CRC), although additional surgical intervention may be indicated based on the risk of lymph node (LN) metastasis. However, risk factors for LN metastasis in T1 CRC not fully established. We investigated the clinicopathological features of T1 CRC and evaluated their association with lymph node metastasis in 133 cases of T1 CRC, consisting of 87 cases with first-line endoscopic resection (EMR) followed by additional surgery and 46 cases with primary surgical resection...
February 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29446494/prepared-for-surgery-communication-in-nurses-pre-operative-consultations-with-patients-undergoing-surgery-for-colorectal-cancer-after-a-person-centred-intervention
#3
M Pettersson, J Öhlen, F Friberg, L C Hydén, C Wallengren, E Sarenmalm, E Carlsson
AIMS AND OBJECTIVES: To describe preoperative communication after a person-centred intervention in nurses' consultations with patients undergoing surgery for colorectal cancer. BACKGROUND: Patients all over the world scheduled for surgery are referred for preoperative consultations with health care professionals. The goal is to assess the risk for perioperative complications, improving quality of care and enabling patients to be prepared for surgery and recovery...
February 15, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29443050/a-co-culture-method-to-investigate-the-crosstalk-between-x-ray-irradiated-caco-2-cells-and-pbmc
#4
Gabriele Babini, Jacopo Morini, Sofia Barbieri, Giorgio Baiocco, Giovanni Battista Ivaldi, Marco Liotta, Paola Tabarelli de Fatis, Andrea Ottolenghi
The protocol adopted in this work aims at unraveling how X-rays perturb the functioning of the intestinal barrier, focusing on the interplay between colorectal tumor cells and the immune system. Colorectal carcinoma is among the most common type of cancer, typically treated by surgery, chemotherapy, and radiotherapy. Advantages of radiotherapy in targeting the tumor are well known. However, even limited exposures of healthy tissues are of great concern, particularly regarding the effects on the intestinal barrier and the immune system...
January 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442241/does-the-number-of-operating-specialists-influence-the-conversion-rate-and-outcomes-after-laparoscopic-colorectal-cancer-surgery
#5
Nader K Francis, Nathan J Curtis, Louise Crilly, Emma Noble, Tamsin Dyke, Rob Hipkiss, Richard Dalton, Andrew Allison, Emad Salib, Jonathan Ockrim
BACKGROUND: Laparoscopic techniques in colorectal surgery have been widely utilised due to short-term patient benefits but conversion to open surgery is associated with adverse short- and long-term patient outcomes. The aim of this study was to investigate the influence of dual specialist operating on the conversion rate and patient outcomes following laparoscopic colorectal surgery. METHODS: A prospectively populated colorectal cancer surgery database was reviewed...
February 13, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29440057/the-role-of-robotics-in-colorectal-surgery
#6
REVIEW
Christina L Cheng, Craig Rezac
Studies of laparoscopic approaches in colorectal surgery support the use of such methods. Compared with the open approach, laparoscopy reduces rates of postoperative complications and decreases length of stay, while providing equivalent oncologic outcomes. Nevertheless, much of colorectal surgery is still being performed by the open approach. This may be partly due to the technical challenges in performing laparoscopy, particularly when working in narrow spaces such as the pelvis. Moreover, some of the current literature has questioned the oncologic outcomes after laparoscopic surgery for rectal cancer...
February 12, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29439668/hipect4-multicentre-randomized-clinical-trial-to-evaluate-safety-and-efficacy-of-hyperthermic-intra-peritoneal-chemotherapy-hipec-with-mitomycin-c-used-during-surgery-for-treatment-of-locally-advanced-colorectal-carcinoma
#7
A Arjona-Sánchez, P Barrios, E Boldo-Roda, B Camps, J Carrasco-Campos, V Concepción Martín, A García-Fadrique, A Gutiérrez-Calvo, R Morales, G Ortega-Pérez, E Pérez-Viejo, A Prada-Villaverde, J Torres-Melero, E Vicente, P Villarejo-Campos, J M Sánchez-Hidalgo, A Casado-Adam, Ruben García-Martin, Manuel Medina, T Caro, C Villar, Enrique Aranda, M T Cano-Osuna, C Díaz-López, E Torres-Tordera, F J Briceño-Delgado, S Rufián-Peña
BACKGROUND: Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6%. There are promising results using prophylactic HIPEC in this group of patients, and it is estimated that up to 26% of all T4 colon cancer could benefit from this treatment with a minimal morbidity. Adjuvant HIPEC is effective to avoid the possibility of peritoneal seeding after surgical resection...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29437041/preoperative-exercise-halves-the-postoperative-complication-rate-in-patients-with-lung-cancer-a-systematic-review-of-the-effect-of-exercise-on-complications-length-of-stay-and-quality-of-life-in-patients-with-cancer
#8
REVIEW
Daniel Steffens, Paula R Beckenkamp, Mark Hancock, Michael Solomon, Jane Young
OBJECTIVE: To investigate the effectiveness of preoperative exercises interventions in patients undergoing oncological surgery, on postoperative complications, length of hospital stay and quality of life. DESIGN: Intervention systematic review with meta-analysis. DATA SOURCES: MEDLINE, Embase and PEDro. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Trials investigating the effectiveness of preoperative exercise for any oncological patient undergoing surgery were included...
February 1, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29435974/association-between-metformin-use-after-surgery-for-colorectal-cancer-and-oncological-outcomes-a-nationwide-register-based-study
#9
Tina Fransgaard, Lau Caspar Thygesen, Ismail Gögenur
Colorectal cancer is one of the most common malignancies in the Western world, and even after surgical removal, there is a high recurrence rate. Metformin treatment has been associated with a reduced risk of developing cancer, but whether metformin influences the risk of recurrence is unknown. The aim of this study was to examine the association between treatment with metformin and recurrence-free-, disease-free survival and all-cause mortality after surgery for colorectal cancer. The study was an observational register-based study and included 25,785 patients, of which 1,116 had medically treated diabetes and 966 started metformin treatment at some point postoperatively...
February 13, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29435759/prognostic-value-of-preoperative-neutrophil-to-lymphocyte-ratio-in-crohn-s-disease
#10
Stanislaus Argeny, Anton Stift, Michael Bergmann, Martina Mittlböck, Svenja Maschke, Yushan Yang, Praminthra Chitsabesan, Stefan Riss
BACKGROUND: The Neutrophil-to-lymphocyte-ratio has recently gained increased attention as a prognostic marker for malignant disease and short term outcomes. There is little data available in patients with Crohn's disease, thus the present study was conducted to correlate preoperative Neutrophil-to-lymphocyte-ratio values with disease phenotype and postoperative course. METHODS: We comprised 373 patients, who underwent intestinal resection for symptomatic Crohn's disease at an academic tertiary referral centre between 2000 and 2014...
February 12, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29435037/analysis-of-the-association-of-the-expression-of-kiss-1-in-colorectal-cancer-tissues-with-the-pathology-and-prognosis
#11
Xinkai Huo, Lei Zhang, Tao Li
Colorectal cancer is a common malignant tumor of the digestive tract with high morbidity and mortality rates. The aim of the present study was to examine the expression level of KiSS-1 in tumor tissues of patients with colorectal cancer, and to explore the relationship with the clinicopathology and prognosis of patients with colorectal cancer. Frozen tumor tissue and corresponding cancer-adjacent normal tissue specimens were selected from 56 patients with colorectal cancer who were treated in the Department of Surgery of our hospital from May 2009 to December 2011...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434964/lymph-node-retrieval-after-dissolution-of-surrounding-adipose-tissue-for-pathological-examination-of-colorectal-cancer
#12
Hiromichi Maeda, Ken Okamoto, Koji Oba, Mai Shiga, Yuki Fujieda, Tsutomu Namikawa, Makoto Hiroi, Ichiro Murakami, Kazuhiro Hanazaki, Michiya Kobayashi
Examination of >12 lymph nodes (LNs) is important for the diagnostic accuracy of nodal status following resection of colorectal cancer. In the present study, the efficacy of a fat dissolution technique for LN retrieval was evaluated using resected colon and rectum mesentery. First, the resected mesentery was searched for LNs by inspection and palpation immediately after surgery. Subsequently, fat dissolution liquid was applied to the remnant fat and the LN search was repeated. The primary endpoint was whether the second assessment would increase the number of evaluated LNs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434834/prognostic-value-of-sparcl1-in-patients-with-colorectal-cancer
#13
Wei Han, Fang Cao, Wei Ding, Xiao-Jiao Gao, Fang Chen, Yong-Wei Hu, Hou-Zhong Ding
Secreted protein acidic and rich in cysteine-like 1 (SPARCL1), a member of extracelluar matrix glycoprotein, has been reported to be associated with various tumor types. The present study aimed to evaluate the prognostic value of SPARCL1 in patients with colorectal cancer. Tissue microarray blocks were constructed based on 79 patients who underwent radical surgery at the Kunshan First People's Hospital between 2008 and 2010. Thirty pairs of fresh-frozen tissues were also obtained for total protein extraction...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433889/psychiatric-disease-in-surgically-treated-colorectal-cancer-patients
#14
Vanessa P Ho, Emily Steinhagen, Kelsey Angell, Suparna M Navale, Nicholas K Schiltz, Andrew P Reimer, Elizabeth A Madigan, Siran M Koroukian
BACKGROUND: Underlying psychiatric conditions may affect outcomes of surgical treatment for colorectal cancer (CRC) because of complex clinical presentation and treatment considerations. We hypothesized that patients with psychiatric illness (PSYCH) would have evidence of advanced disease at presentation, as manifested by higher rates of colorectal surgery performed in the presence of obstruction, perforation, and/or peritonitis (OPP-surgery). MATERIALS AND METHODS: Using data from the 2007-2011 National Inpatient Sample, we identified patients with a diagnosis of CRC undergoing colorectal surgery...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433159/prognostic-utility-of-histological-growth-patterns-of-colorectal-lung-oligometastases
#15
Son Jae Yeong, Min Gyoung Pak, Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh
Background: Patients with resectable colorectal lung oligometastases demonstrate a heterogeneous oncological outcome. However, the parameters for predicting tumor aggressiveness have not yet been fully investigated in colorectal lung metastases (CLM). This study was performed to determine the prognostic value of histological growth patterns in patients who underwent surgery for CLM. Materials and Methods: The study included 92 patients who were diagnosed with CLM among the first resection cases...
February 12, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29432970/high-tie-versus-low-tie-of-the-inferior-mesenteric-artery-in-colorectal-cancer-a-meta-analysis
#16
REVIEW
Yafan Yang, Guiying Wang, Jingli He, Jianfeng Zhang, Jinchuan Xi, Feifei Wang
BACKGROUND: Colorectal cancer surgery includes "high tie" and "low tie"of the inferior mesenteric artery(IMA). However, different ligation level is closely related to the blood supply of anastomosis, which may increase the leakage rate, and it is unclear which technique confers a lower anastomotic leakage rate(AL) and survival advantage. OBJECTIVE: To compare the effectiveness and impact of inferior mesenteric artery (IMA) high ligation versus IMA low ligation on anastomotic leakage, lymph nodes yield rates and 5-year survival...
February 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29429053/program-of-gastrointestinal-rehabilitation-and-early-postoperative-enteral-nutrition-a-prospective-study
#17
Frank Daniel Martos-Benítez, Anarelys Gutiérrez-Noyola, Andrés Soto-García, Iraida González-Martínez, Ilionanys Betancourt-Plaza
Nutritional depletion is commonly observed in patients undergoing surgical treatment for a gastrointestinal malignancy. An appropriate nutritional intervention could be associated with improved postoperative outcomes. The study was aimed to determine the effect of a program of gastrointestinal rehabilitation and early postoperative enteral nutrition upon complications and clinical outcomes in patients who experienced gastrointestinal surgery for cancer. This is a prospective study (2013 January-2015 December) of 465 consecutive patients submitted to gastrointestinal surgery for cancer and admitted to an Oncological Intensive Care Unit...
February 10, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29428475/peritoneal-metastases-invading-the-seminal-vesicles-radiologic-appearance-and-outcome-of-treatment
#18
Paul H Sugarbaker
BACKGROUND: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) may be of greatest benefit if all visible evidence of disease is resected. In some male patients the peritoneal metastases within the pelvis are invasive into the seminal vesicles and complete cytoreduction requires resection of these structures. PATIENTS AND METHODS: From a prospective database of colorectal and appendiceal cancer patients who had CT evidence of seminal vesicle involvement and then had cytoreduction including resection of the seminal vesicles were reviewed...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29428473/urinary-dysfunction-after-rectal-cancer-surgery-results-from-a-randomized-trial-comparing-mesorectal-excision-with-and-without-lateral-lymph-node-dissection-for-clinical-stage-ii-or-iii-lower-rectal-cancer-japan-clinical-oncology-group-study-jcog0212
#19
Masaaki Ito, Akihiro Kobayashi, Shin Fujita, Junki Mizusawa, Yukihide Kanemitsu, Yusuke Kinugasa, Koji Komori, Masayuki Ohue, Mitsuyoshi Ota, Yoshihiro Akazai, Manabu Shiozawa, Takashi Yamaguchi, Takayuki Akasu, Yoshihiro Moriya
BACKGROUND: Postoperative urinary dysfunction is a major complication of rectal cancer surgery. A randomized controlled trial (JCOG0212) concluded that the noninferiority of mesorectal excision alone to mesorectal excision with lateral lymph node dissection was not confirmed in terms of relapse-free survival. METHODS: Eligibility criteria included histologically proven clinical stage II/III rectal cancer, a main lesion located in the rectum with the lower margin below the peritoneal reflection, and the absence of lateral lymph node enlargement...
January 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29428157/retraction-notice-to-high-concentration-supplemental-perioperative-oxygen-and-surgical-site-infection-following-elective-colorectal-surgery-for-rectal-cancer-a-prospective-randomized-double-blind-controlled-single-site-trial-am-j-surg-208-2014-719-726
#20
Mario Schietroma, Emanuela M Cecilia, Federico Sista, Francesco Carlei, Beatrice Pessia, Gianfranco Amicucci
No abstract text is available yet for this article.
February 7, 2018: American Journal of Surgery
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