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Colorectal cancer surgery

Nina C A Vermeer, Renu R Bahadoer, Esther Bastiaannet, Fabian A Holman, Elma Meershoek-Klein Kranenbarg, Gerrit-Jan Liefers, Cornelis J H van de Velde, Koen C M J Peeters
AIM: In 2014, a national colorectal cancer (CRC) screening program was launched in the Netherlands. It is difficult to assess for the individual CRC patient whether the oncological benefits of surgery will outweigh the morbidity of the procedure, especially in early lesions. This study compares patient and tumour characteristics between screen-detected and non-screen-detected patients. Secondly, we present an overview of treatment options and clinical dilemmas when treating patients with early stage colorectal disease...
June 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
X-L Yi, J-T Wang, C-Q Chu, Y-X Li, J-H Yin, S-L Liu
OBJECTIVE: To explore the cardiocerebral protective effect of dexmedetomidine as an anesthetic in colorectal cancer surgery. PATIENTS AND METHODS: A total of 246 colorectal cancer patients were enrolled in this retrospective analysis. Those patients were admitted to the Affiliated Hospital of Qingdao University and underwent surgery from July 2014 to July 2016. The patients were divided into observation group and control group according to the anesthetic used in surgery...
June 2018: European Review for Medical and Pharmacological Sciences
H Xu, Y-J Ren, K Liu, X-L Min, L Yang, Y Zhou, J Zheng, C Yang
OBJECTIVE: To investigate the correlations of serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) levels with colorectal liver metastasis (CLM) in patients with colorectal cancer (CRC), and determine the effects of transhepatic arterial chemoembolization (TACE) on their expressions. PATIENTS AND METHODS: A total of 110 CRC patients treated in the department of interventional radiology of our hospital from May 2013 to May 2016 were randomly enrolled...
June 2018: European Review for Medical and Pharmacological Sciences
Jeroen L A van Vugt, Robert R J Coebergh van den Braak, Zarina S Lalmahomed, Wietske W Vrijland, Jan W T Dekker, David D E Zimmerman, Wouter J Vles, Peter-Paul L O Coene, Jan N M IJzermans
BACKGROUND: Preoperative low skeletal muscle mass and density are associated with increased postoperative morbidity in patients undergoing curative colorectal cancer (CRC) surgery. However, the long-term effects of low skeletal muscle mass and density remain uncertain. METHODS: Patients with stage I-III CRC undergoing surgery, enrolled in a prospective observational cohort study, were included. Skeletal muscle mass and density were measured on CT. Patients with high and low skeletal muscle mass and density were compared regarding postoperative complications, disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS)...
June 6, 2018: European Journal of Surgical Oncology
Liulu Zhang, Yijie Huang, Ciqiu Yang, Teng Zhu, Yufeng Lin, Hongfei Gao, Mei Yang, Minyi Cheng, Kun Wang
BACKGROUND: To stage axillary lymph nodes in women with early-stage breast cancer, sentinel lymph node biopsy (SLNB), rather than axillary lymph node dissection (ALND), has been employed. Moreover, different tracer methods have various advantages and disadvantages. In recent years, carbon nanoparticle suspensions (CNSs) have been used as lymph node tracers during surgeries for thyroid cancer, gastric cancer, and colorectal cancer. The study retrospectively analyzed the feasibility and accuracy of CNS for sentinel lymph node (SLN) mapping in patients with early breast cancer...
June 19, 2018: World Journal of Surgical Oncology
Tak Kyu Oh, Sung-Bum Kang, In-Ae Song, Jung-Won Hwang, Sang-Hwan Do, Jin Hee Kim, Ah-Young Oh
Purpose: This study aimed to identify the effect of preoperative serum total cholesterol on postoperative pain outcome in patients who had undergone laparoscopic colorectal cancer surgery. Methods: We retrospectively reviewed the medical records of patients diagnosed with colorectal cancer who had undergone laparoscopic colorectal surgery from January 1, 2011, to June 30, 2017, to identify the relationship of total cholesterol levels within a month prior to surgery with the numeric rating scale (NRS) scores and total opioid consumption on postoperative days (PODs) 0-2...
2018: Journal of Pain Research
Hua-Li Song, Dong-Mei Zhang, Heng Wen, Meng Wang, Na Zhao, Yu-Hua Gao, Ni Ding
BACKGROUND: Although peritoneal lavage with povidone-iodine (PVPI) is frequently performed after surgery on the gastrointestinal tract, the effects of PVPI on the intestinal epithelial barrier are unknown. The purpose of this study was to investigate the effects of abdominal irrigation with PVPI on the intestinal epithelial barrier in a colorectal cancer (CRC)-induced rat model. MATERIALS AND METHODS: The CRC model was induced in rats with azoxymethane and dextran sodium sulfate...
August 2018: Journal of Surgical Research
Kei Ito, Keiji Nihei, Takuya Shimizuguchi, Hiroaki Ogawa, Tomohisa Furuya, Shurei Sugita, Takahiro Hozumi, Keisuke Sasai, Katsuyuki Karasawa
OBJECTIVE This study aimed to clarify the outcomes of postoperative re-irradiation using stereotactic body radiotherapy (SBRT) for metastatic epidural spinal cord compression (MESCC) in the authors' institution and to identify factors correlated with local control. METHODS Cases in which patients with previously irradiated MESCC underwent decompression surgery followed by spine SBRT as re-irradiation between April 2013 and May 2017 were retrospectively reviewed. The surgical procedures were mainly performed by the posterior approach and included decompression and fixation...
June 15, 2018: Journal of Neurosurgery. Spine
Rikke Karlin Jepsen, Guy Wayne Novotny, Louise Laurberg Klarskov, Claus Heiner Bang-Bertelsen, Ida Trondhjem Haakansson, Anker Hansen, Ib Jarle Christensen, Lene Buhl Riis Ass, Estrid Høgdall
Accurate prediction of regional lymph node metastases (LNM) in endoscopically resected pT1 colorectal cancer (CRC) is crucial in treatment stratification for subsequent radical surgery. Several miRNAs have been linked to CRC invasion and metastasis, including the oncogenic miR-17/92 cluster, and expression levels might have predictive value in the risk assessment of early metastatic progression in CRC. We performed global miRNA microarray using tissue samples from the invasive front of pT1 CRC and investigated associations of the miR-17/92 cluster and presence of LNM...
June 11, 2018: Human Pathology
Hye-Sung Jo, Dong-Sik Kim, Sung-Won Jung, Young-Dong Yu, Sae-Byeol Choi, Wan-Bae Kim, Hyung-Joon Han, Tae-Jin Song
Backgrounds/Aims: This study attempted to identify risk factors for development of post-hepatectomy hepatic failure (PHF) and its effect on long-term survival of patients with liver metastases from colorectal cancer. Methods: We carried out a retrospective study of 143 patients who had been diagnosed with liver metastases from colorectal cancer and who had undergone hepatectomy between 2003 and 2010. We allocated these patients to PHF and non-PHF groups, using the definition of the International Study Group of Liver Surgery, and compared the clinical factors of the two groups, using Cox regression and Kaplan-Meier analysis to evaluate the differences in overall survival (OS) and recurrence-free survival (RFS) between these groups...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
Febe Friberg, Catarina Wallengren, Cecilia Håkanson, Eva Carlsson, Frida Smith, Monica Pettersson, Elisabeth Kenne Sarenmalm, Richard Sawatzky, Joakim Öhlén
BACKGROUND: The assessment and evaluation of practical and sustainable development of health care has become a major focus of investigation in health services research. A key challenge for researchers as well as decision-makers in health care is to understand mechanisms influencing how complex interventions work and become embedded in practice, which is significant for both evaluation and later implementation. In this study, we explored nurses' and surgeons' perspectives on performing and participating in a complex multi-centre person-centred intervention process that aimed to support patients diagnosed with colorectal cancer to feel prepared for surgery, discharge and recovery...
June 13, 2018: BMC Health Services Research
Min Sung An, HyungJoo Baik, Se Hui Oh, Yo-Han Park, Sang Hyuk Seo, Kwang Hee Kim, Kwan Hee Hong, Ki Beom Bae
BACKGROUND: Complete mesocolic excision (CME) has been proposed for colon cancer to improve oncological outcomes. The risks and benefits of laparoscopic CME have not been examined fully. We compared short- and long-term outcomes of CME with a conventional mesocolic excision (non-CME) in laparoscopic right hemicolectomy (RHC) for right-sided colon cancer. METHODS: In total, 115 patients who underwent laparoscopic RHC with stage I-III right-sided colon cancer at Busan Paik Hospital from August 2007 to October 2011 were enrolled in this case-control study...
June 12, 2018: ANZ Journal of Surgery
Syed Nabeel Zafar, Adil A Shah, Christine Nembhard, Lori L Wilson, Elizabeth B Habermann, Mustafa Raoof, Nabil Wasif
PURPOSE: Hospital readmissions after surgery are a focus of quality improvement efforts. Although some reflect appropriate care, others are potentially preventable readmissions (PPRs). We aim to describe the burden, timing, and factors associated with readmissions after complex cancer surgery. METHODS: The Nationwide Readmissions Database (2013) was used to select patients undergoing a complex oncologic resection, which was defined as esophagectomy/gastrectomy, hepatectomy, pancreatectomy, colorectal resection, lung resection, or cystectomy...
June 2018: Journal of Oncology Practice
Morgane Bouquot, Ben Creavin, Nicolas Goasguen, Najim Chafai, Emmanuel Tiret, Thierry André, Jean-Francois Flejou, Yann Parc, Jérémie H Lefevre, Magali Svrcek
The presence of tumor deposits (TD) in colorectal cancer (CRC) is associated with poor prognosis. The 7th edition of TNM subclassified a new nodal stage, N1c, characterized by the presence of TD without any concurrent positive lymph node (LN). It is not clear if the N1c category is equal or not to LN metastasis. We aimed to examine the prevalence, characteristics and prognostic significance of this new subcategory METHODS: Consecutive patients who underwent surgery for CRC in two centers (2011-2014) were analyzed...
June 12, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Zaibaa Patel, Mohamed A Thaha, Panayiotis A Kyriacou
<i>Objective:</i> Intestinal anastomotic failure that occurs mainly due to ischaemia is a serious risk in colorectal cancer patients undergoing surgery. Surgeons continue to rely on subjective methods such as visual inspection to assess intestinal viability during surgery and there are no clinical tools to directly monitor viability postoperatively. A dual wavelength, reflectance optical sensor has been developed for continuous and dynamic monitoring of intestinal viability via the intestinal lumen...
June 12, 2018: Physiological Measurement
Meral Gunaldi, Nilgun Isiksacan, Hakan Kocoglu, Yildiz Okuturlar, Omur Gunaldi, Turkan Ozturk Topcu, Mehmet Karabulut
Objective: Survivin is one of the apoptosis inhibitor proteins, and it plays a key role in tumor angiogenesis and cancer progression. This study was conducted to investigate the serum level of survivin to determine its diagnostic value in cancer patients. Materials and Methods: Blood samples were taken from cancer patients (n = 67) prior to surgery or chemo/radiotherapy and age-matched healthy volunteers (n = 23). The serum levels of survivin were analyzed by enzyme-linked immunosorbent assays...
April 2018: Journal of Cancer Research and Therapeutics
Daniëlle D Huijts, Julia T van Groningen, Onno R Guicherit, Jan Willem T Dekker, Leti van Bodegom-Vos, Esther Bastiaannet, Johannes A Govaert, Michel W Wouters, Perla J Marang-van de Mheen
Background: It is unclear whether emergency weekend colon and rectal cancer surgery are associated with worse outcomes (ie, weekend effect) because previous studies mostly used administrative data, which may insufficiently adjust for case-mix. Materials and Methods: Prospectively collected data from the 2012-2015 Dutch ColoRectal Audit (n=5,224) was used to examine differences in 30-day mortality and severe complication and failure-to-rescue rates for emergency weekend (Saturday and Sunday) versus Monday surgery, stratified for colon and rectal cancer...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Matthieu Zellweger, Etienne Abdelnour-Berchtold, Thorsten Krueger, Hans-Beat Ris, Jean Yannis Perentes, Michel Gonzalez
Colorectal cancer (CRC) is a frequently occurring disease, yet diagnosed at a local stage in only 40% of cases. Lung metastases (LM) appear in 5-15% of patients and, left untreated, carry a very poor prognosis. Some CRC patients may benefit from a potentially curative LM resection, but success and benefit are difficult to predict. We discuss prognostic factors of survival after lung metastasectomy in CRC patients under several scenarios (with/ without prior liver metastases; repetitive pulmonary resections)...
July 2018: Critical Reviews in Oncology/hematology
Pieter-Jan Cuyle, Anke Engelen, Veerle Moons, Tim Tollens, Saskia Carton
Objective: Patients with stage III and high-risk stage II colorectal cancer (CRC) are advised to initiate adjuvant treatment as soon as feasible and certainly before 8 to 12 weeks after resection of the tumor. A protective ileostomy is often constructed during surgery to protect a primary anastomosis "at risk", especially in rectal cancer surgery. However, up to 17% of patients with a stoma suffer from high output, a major complication that can prevent adjuvant treatment implementation or completion...
2018: Journal of Drug Assessment
Lotte Linnemann Rønfeldt, Dorthe Hjort Jakobsen, Henrik Kehlet, Henriette Lipczak, Kasper Wennerwaldt
INTRODUCTION: Clinical practice guidelines (CPGs) support enhanced post-operative recovery and decrease morbidity. In addition, patient information leaflets (PILs) are associated with enhanced overall outcomes and improved patient satisfaction. The aim of this study was to provide an overview of the quality of CPGs and PILs in cancer surgery departments undertaking pulmonary lobectomy, nephrectomy, cystectomy, whipples, colorectal and ovarian surgery. METHODS: We conducted a cross-sectional descriptive study within 44 surgical departments in six cancer subspecialties: lung (n = 4), kidney (n = 9), bladder (n = 5), pancreas (n = 4), colorectal (n = 18) and ovarian (n = 4)...
June 2018: Danish Medical Journal
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