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Metastatic colorectal cancer surgery

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https://www.readbyqxmd.com/read/27888624/rhoa-regulates-resistance-to-irinotecan-by-regulating-membrane-transporter-and-apoptosis-signaling-in-colorectal-cancer
#1
Huang Ruihua, Zhang Mengyi, Zhao Chong, Qiu Meng, Ma Xin, Tang Qiulin, Bi Feng, Liu Ming
Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. While surgery remains the mainstay of treatment in early stage CRC, chemotherapy is usually given to prolong the overall survival and improve the quality of life for metastatic colorectal cancer (mCRC). But drug resistance is one of the major hurdles of mCRC treatment, and the underlying mechanisms are still largely unknown. In this study, we show that, compared with parental cells, RhoA is up-regulated in irinotecan (CPT-11)-resistant CRC cells...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27884041/follow-up-strategies-for-patients-treated-for-non-metastatic-colorectal-cancer
#2
REVIEW
Mark Jeffery, Brigid E Hickey, Phil N Hider, Adrienne M See
BACKGROUND: It is common clinical practice to follow patients with colorectal cancer (CRC) for several years following their curative surgery or adjuvant therapy, or both. Despite this widespread practice, there is considerable controversy about how often patients should be seen, what tests should be performed, and whether these varying strategies have any significant impact on patient outcomes. This is the second update of a Cochrane Review first published in 2002 and first updated in 2007...
November 24, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27875625/clinical-and-genetic-determinants-of-ovarian-metastases-from-colorectal-cancer
#3
Karuna Ganesh, Ronak H Shah, Efsevia Vakiani, Garrett M Nash, Hugh P Skottowe, Rona Yaeger, Andrea Cercek, Anne Lincoln, Christina Tran, Neil H Segal, Diane L Reidy, Anna Varghese, Andrew S Epstein, Yukio Sonoda, Dennis Chi, Jose Guillem, Larissa Temple, Philip Paty, Jaclyn Hechtman, Jinru Shia, Martin Weiser, Julio Garcia Aguilar, Nancy Kemeny, Michael F Berger, Leonard Saltz, Zsofia K Stadler
BACKGROUND: Ovarian metastases from colorectal cancer (OM-CRC) often are unresponsive to chemotherapy and are associated with poor survival. To the authors' knowledge, the clinicopathologic and genomic predictors of OM-CRC are poorly characterized and optimal clinical management remains unclear. METHODS: Women with a histopathological diagnosis of OM-CRC who were treated at Memorial Sloan Kettering Cancer Center from 1999 to 2015 were identified. Next-generation somatic mutation profiling (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) was performed on 38 OM-CRC cases, including 21 matched tumor pairs/trios...
November 22, 2016: Cancer
https://www.readbyqxmd.com/read/27864747/surgical-management-of-metastatic-colorectal-cancer-a-single-centre-experience-on-oncological-outcomes-of-pulmonary-resection-vs-cytoreductive-surgery-and-hipec
#4
Evelyn Yi Ting Wong, Grace Hwei Ching Tan, Deanna Wan Jie Ng, Tina Puay Theng Koh, Mrinal Kumar, Melissa Ching Ching Teo
PURPOSE: Metastasectomy is accepted as standard of care for selected patients with colorectal pulmonary metastases (CLM); however, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastases (CPM) is not universally accepted. We aim to compare oncological outcomes of patients with CLM and CPM after pulmonary resection and CRS-HIPEC, respectively, by comparing overall survival (OS) and disease-free survival (DFS). METHODS: A retrospective review of 49 CLM patients who underwent pulmonary resection, and 52 CPM patients who underwent CRS-HIPEC in a single institution from January 2003 to March 2015, was performed...
November 19, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27863403/enumeration-and-targeted-analysis-of-kras-braf-and-pik3ca-mutations-in-ctcs-captured-by-a-label-free-platform-comparison-to-ctdna-and-tissue-in-metastatic-colorectal-cancer
#5
Evelyn Kidess-Sigal, Haiyan E Liu, Melanie M Triboulet, James Che, Vishnu C Ramani, Brendan C Visser, George A Poultsides, Teri A Longacre, Andre Marziali, Valentina Vysotskaia, Matthew Wiggin, Kyra Heirich, Violet Hanft, Ulrich Keilholz, Ingeborg Tinhofer, Jeffrey A Norton, Mark Lee, Elodie Sollier-Christen, Stefanie S Jeffrey
Treatment of advanced colorectal cancer (CRC) requires multimodal therapeutic approaches and need for monitoring tumor plasticity. Liquid biopsy biomarkers, including CTCs and ctDNA, hold promise for evaluating treatment response in real-time and guiding therapeutic modifications. From 15 patients with advanced CRC undergoing liver metastasectomy with curative intent, we collected 41 blood samples at different time points before and after surgery for CTC isolation and quantification using label-free Vortex technology...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27863343/acrometastasis-following-colorectal-cancer-a-case-report-and-review-of-literature
#6
Kozar Agha, Khalid Akbari, Syed Husain Abbas, Simon Middleton, Daniel McGrath
INTRODUCTION: Colorectal cancer commonly metastasises to the liver, peritoneum and lungs. Bony metastases are uncommon in colorectal cancer and in particular metastases to the hands or feet (acrometastasis) are an extremely rare occurrence. CASE PRESENTATION: A 65-year-old male with a colonic malignancy underwent elective anterior resection. Intra-operatively he was found to have a pelvic collection necessitating an end colostomy. Histology confirmed complete Dukes B tumour excision with no evidence of lymph node metastases...
November 10, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27863086/is-it-important-to-palpate-lymph-nodes-in-open-surgery-for-colorectal-cancer
#7
Yusuke Yamaoka, Yusuke Kinugasa, Akio Shiomi, Tomohiro Yamaguchi, Hiroyasu Kagawa, Yushi Yamakawa, Akinobu Furutani, Masakatsu Numata
INTRODUCTION: In laparoscopic or robotic surgery, surgeons cannot directly palpate lymph nodes (LN), which could be considered a shortcoming in that procedure. This study was performed to evaluate the importance of palpation diagnosis of LN metastasis in colorectal cancer surgery. METHODS: This study enrolled 408 patients who underwent curative resection for primary colorectal cancer in our department in 2014. The diameter of each manually dissected LN was measured, and the LN was then examined by palpation to determine whether it was metastatic based on its consistency...
November 8, 2016: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/27862779/elective-hepatic-resection-is-feasible-and-safe-in-a-regional-centre
#8
Andrew D Gray, George Petrou, Pratik Rastogi, Stephen Begbie
BACKGROUND: Hepatic resectional surgery remains a highly specialized area of general surgery usually reserved for completion at tertiary metropolitan referral centres. Port Macquarie, on the Mid North Coast of New South Wales, is the only regionally based hospital offering surgery of this nature in mainland Australia. The purpose of this study is to review the data for patients undergoing hepatic resectional surgery in this non-metropolitan centre in order to illustrate that these operations can be carried out safely in a regional setting with comparable results to tertiary-level centres...
November 14, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27852040/clinical-validation-of-prospective-liquid-biopsy-monitoring-in-patients-with-wild-type-ras-metastatic-colorectal-cancer-treated-with-folfiri-cetuximab
#9
Rodrigo A Toledo, Antonio Cubillo, Estela Vega, Elena Garralda, Rafael Alvarez, Lisardo U de la Varga, Jesús R Pascual, Gema Sánchez, Francesca Sarno, Susana H Prieto, Sofía Perea, Pedro P Lopéz-Casas, Fernando López-Ríos, Manuel Hidalgo
Cancer genomics and translational medicine rely on the molecular profiling of patient's tumor obtained during surgery or biopsy. Alternatively, blood is a less invasive source of tumor DNA shed, amongst other ways, as cell-free DNA (cfDNA). Highly-sensitive assays capable to detect cancer genetic events from patient's blood plasma became popularly known as liquid biopsy (LqB). Importantly, retrospective studies including small number of selected patients with metastatic colorectal cancer (mCRC) patients treated with anti-EGFR therapy have shown LqB capable to detect the acquired clonal mutations in RAS genes leading to therapy resistance...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27843609/novel-prognostic-prediction-models-for-patients-with-stage-iv-colorectal-cancer-after-concurrent-curative-resection
#10
N Miyoshi, M Ohue, M Yasui, S Noura, T Shingai, K Sugimura, H Akita, K Gotoh, S Marubashi, H Takahashi, J Okami, Y Fujiwara, M Higashiyama, M Yano
BACKGROUND: We developed a prediction tool for recurrence and survival in patients with stage IV colorectal cancer (CRC) following surgically curative resection. PATIENTS AND METHODS: From January 1983 to December 2012, 113 patients with CRC and synchronous liver and/or lung metastatic CRC were investigated at the Osaka Medical Center for Cancer and Cardiovascular Diseases. All patients underwent curative resection of primary and metastatic lesions. In the group of patients who underwent surgery from 1983 to 2008, a Cox regression model was used to develop prediction models for 1-year, 3-year and 5-year cancer-specific survival (CSS) and relapse-free survival (RFS)...
2016: ESMO Open
https://www.readbyqxmd.com/read/27822086/danish-colorectal-cancer-group-database
#11
REVIEW
Peter Ingeholm, Ismail Gögenur, Lene H Iversen
AIM OF DATABASE: The aim of the database, which has existed for registration of all patients with colorectal cancer in Denmark since 2001, is to improve the prognosis for this patient group. STUDY POPULATION: All Danish patients with newly diagnosed colorectal cancer who are either diagnosed or treated in a surgical department of a public Danish hospital. MAIN VARIABLES: The database comprises an array of surgical, radiological, oncological, and pathological variables...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27803242/an-unusual-site-of-metastasis-splenic-metastastasis-from-a-colon-cancer
#12
Boubacar Efared, Asmae Mazti, Gabrielle Atsame-Ebang, Layla Tahiri, Hicham El Bouhaddouti, Nawal Hammas, Hind El Fatemi, Laila Chbani
Splenic metastasis from colorectal cancers is a very rare occurrence. Few cases have been reported in the literature. We report herein an additionnal case of metachronous splenic metastasis from adenocarcinoma of the sigmoid colon, 3 years after the diagnosis of the primary tumor. A 62-year old woman presented for regular follow-up after colectomy for sigmoid colon adenocarcinoma. A computed tomography-scan found two splenic metastatic nodules for which splenectomy had been performed. The histological analysis of the resected spleen showed a well-differentiated metastatic adenocarcinoma from colon...
November 1, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27779683/pien-tze-huang-suppresses-vegf-c-mediated-lymphangiogenesis-in-colorectal-cancer
#13
Jiumao Lin, Jianyu Feng, Yiyi Jin, Zhaokun Yan, Zijun Lai, Jun Peng
Colorectal cancer (CRC) is one of the most common malignancies worldwide. The majority of patients are not suitable for surgery due to the presence of metastatic disease at the time of diagnosis, which has led to a high mortality rate for patients with CRC. Lymphangiogenesis, formation of new lymphatic vessels, plays an critical role in cancer progression particularly in cancer metastasis. Vascular endothelial growth factor-C (VEGF-C) has been previously demonstrated to play a pivotal role in cancer metastasis and therefore has become an attractive target for anticancer treatments...
October 20, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27771609/efficacy-of-nedd8-pathway-inhibition-in-preclinical-models-of-poorly-differentiated-clinically-aggressive-colorectal-cancer
#14
Gabriele Picco, Consalvo Petti, Francesco Sassi, Katia Grillone, Giorgia Migliardi, Teresa Rossi, Claudio Isella, Federica Di Nicolantonio, Ivana Sarotto, Anna Sapino, Alberto Bardelli, Livio Trusolino, Andrea Bertotti, Enzo Medico
BACKGROUND: The NEDD8 conjugation pathway modulates the ubiquitination and activity of a wide range of intracellular proteins, and its blockade by pevonedistat is emerging as a promising therapeutic approach in various cancer settings. However, systematic characterization of pevonedistat efficacy in specific tumor types and definition of response predictors are still missing. METHODS: We investigated in vitro sensitivity to pevonedistat in 122 colorectal cancer (CRC) cell lines by an ATP-based proliferation assay and evaluated apoptosis and DNA content by flow cytometry...
February 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27760013/distant-liver-metastases-as-a-major-factor-influencing-survival-in-patients-with-colorectal-cancer
#15
Dimitar K Penchev, Lilyana V Vladova, Miroslav Z Zashev, Radosvet P Gornev
AIM: To assess the effect of the factor 'hepatic metastatic disease' on long-term outcomes in patients with colorectal cancer. MATERIALS AND METHODS: We analysed retrospectively 200 randomly selected patients. Forty-two of them were excluded from the study for different reasons so the study contingent was 158 patients over a period of 23 years. All were diagnosed and treated in the Lozenetz University Hospital, in the Department of General Surgery. 125 of the patients were diagnosed with colorectal cancer without distant metastases and 33 of the patients had liver metastases as a result of colorectal carcinoma...
September 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/27733119/critical-care-provision-after-colorectal-cancer-surgery
#16
C D Dale, P McLoone, B Sloan, J Kinsella, D Morrison, K Puxty, T Quasim
BACKGROUND: Colorectal cancer (CRC) is the 2nd largest cause of cancer related mortality in the UK with 40 000 new patients being diagnosed each year. Complications of CRC surgery can occur in the perioperative period that leads to the requirement of organ support. The aim of this study was to identify pre-operative risk factors that increased the likelihood of this occurring. METHODS: This is a retrospective observational study of all 6441 patients who underwent colorectal cancer surgery within the West of Scotland Region between 2005 and 2011...
October 12, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27697193/outcomes-after-repeat-hepatic-resection-for-recurrent-metastatic-colorectal-cancer-a-population-based-study
#17
Sulaiman Nanji, Melanie E Tsang, Xuejiao Wei, Christopher M Booth
BACKGROUND: More than half of the patients undergoing resection for colorectal cancer liver metastases develop recurrent hepatic disease. We report management and outcomes of patients undergoing repeat hepatectomy in routine practice. METHODS: All cases of repeat hepatectomy for colorectal cancer liver metastases from 2002 to 2009 in the Canadian Province of Ontario were identified using the population-based Ontario Cancer Registry and linked treatment records. RESULTS: Of 1,310 patients who underwent resection of CRLM, 78 (6...
September 6, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27696448/effective-fluorescence-guided-surgery-of-liver-metastasis-using-a-fluorescent-anti-cea-antibody
#18
Yukihiko Hiroshima, Thinzar M Lwin, Takashi Murakami, Ali A Mawy, Tanaka Kuniya, Takashi Chishima, Itaru Endo, Bryan M Clary, Robert M Hoffman, Michael Bouvet
BACKGROUND AND OBJECTIVES: Delineation of adequate tumor margins is critical in oncologic surgery, particularly in resection of metastatic lesions. Surgeons are limited in visualization with bright-light surgery, but fluorescence-guided surgery (FGS) has been efficacious in helping the surgeon achieve negative margins. METHODS: The present study uses FGS in a mouse model that has undergone surgical orthotopic implantation (SOI) of colorectal liver metastasis tagged with green fluorescent protein (GFP)...
October 3, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27686666/pathological-complete-response-after-neoadjuvant-chemotherapy-for-rectal-cancer-with-synchronous-multiple-liver-metastases-a-report-of-an-unusual-case
#19
Ryosuke Arata, Toshiyuki Itamoto, Satoshi Ikeda, Hideki Nakahara, Akihiko Oshita, Katsunori Shinozaki, Takashi Nishisaka
BACKGROUND: Systemic chemotherapy for stage IV colorectal cancer has advanced markedly in the recent years. We report an unusual case of 13 synchronous liver metastases for which a pathological complete response was achieved with neoadjuvant chemotherapy (NAC) consisting of a combination of 5-fluorouracil (5-FU), oxaliplatin, leucovorin (mFOLFOX6), and bevacizumab. CASE PRESENTATION: A 44-year-old man was diagnosed with colorectal cancer with synchronous liver metastases...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27685920/survival-and-prognostic-factors-in-patients-with-brain-metastasis-single-center-experience
#20
Kemal Ekici, Oztun Temelli, Mustafa Dikilitas, Ibrahim Halil Dursun, Nihal Bozdag Kaplan, Ersoy Kekilli
PURPOSE: The purpose of this study was to evaluate the clinical status, prognostic factors and treatment modalities affecting survival in patients with brain metastasis. We aimed to evaluate the whole brain radiation therapy (WBRT) outcomes of patients with brain metastasis in our center. METHODS: Clinical data of 315 patients referred to our center between 2004 and 2014 with metastatic brain cancers were collected and analysed for possible relationships between survival time, age, gender, Karnofsky performance status (KPS), recursive partitioning analysis (RPA), primary tumor, number of brain lesions, surgery, radiation therapy scheme, extracranial metastatic status and primary disease control status...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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