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https://www.readbyqxmd.com/read/29907305/metabolic-engineering-to-increase-crop-yield-from-concept-to-execution
#1
Frank A Skraly, Madana M R Ambavaram, Oliver Peoples, Kristi D Snell
Although the return on investment over the last 20 years for mass screening of individual plant genes to improve crop performance has been low, the investment in these activities was essential to establish the infrastructure and tools of modern plant genomics. Complex traits such as crop yield are likely multigenic, and the exhaustive screening of random gene combinations to achieve yield gains is not realistic. Clearly, smart approaches must be developed. In silico analyses of plant metabolism and gene networks can move a trait discovery program beyond trial-and-error approaches and towards rational design strategies...
August 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29904606/starting-the-conversation-community-perspectives-on-preterm-birth-and-kangaroo-mother-care-in-southern-malawi
#2
Megan Lydon, Monica Longwe, Dyson Likomwa, Victoria Lwesha, Lydia Chimtembo, Pamela Donohue, Tanya Guenther, Bina Valsangar
Background: Despite introduction of Kangaroo Mother Care (KMC) in Malawi over a decade ago, preterm birth remains the leading cause of neonatal mortality. Although KMC is initiated in the health care facility, robust community follow-up is critical for survival and optimal development of preterm and low birth weight infants post-discharge. The objective of this qualitative study was to gain insight into community and health worker understanding, attitudes, beliefs and practices around preterm and low birth weight babies and KMC in Malawi...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29904163/physicians-perspectives-on-receiving-unsolicited-genomic-results
#3
Douglas B Pet, Ingrid A Holm, Janet L Williams, Melanie F Myers, Laurie L Novak, Kyle B Brothers, Georgia L Wiesner, Ellen W Clayton
PURPOSE: Physicians increasingly receive genomic test results they did not order, which we term "unsolicited genomic results" (UGRs). We asked physicians how they think such results will affect them and their patients. METHODS: Semistructured interviews were conducted with adult and pediatric primary care and subspecialty physicians at four sites affiliated with a large-scale return-of-results project led by the Electronic Medical Records and Genomics (eMERGE) Network...
June 14, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29903532/muscleless-motor-synergies-and-actions-without-movements-from-motor-neuroscience-to-cognitive-robotics
#4
REVIEW
Vishwanathan Mohan, Ajaz Bhat, Pietro Morasso
Emerging trends in neurosciences are providing converging evidence that cortical networks in predominantly motor areas are activated in several contexts related to 'action' that do not cause any overt movement. Indeed for any complex body, human or embodied robot inhabiting unstructured environments, the dual processes of shaping motor output during action execution and providing the self with information related to feasibility, consequence and understanding of potential actions (of oneself/others) must seamlessly alternate during goal-oriented behaviors, social interactions...
April 27, 2018: Physics of Life Reviews
https://www.readbyqxmd.com/read/29902552/exploring-the-major-cross-talking-edges-of-competitive-endogenous-rna-networks-in-human-chronic-and-acute-myeloid-leukemia
#5
Kamalika Sen, Dhananjay Bhattacharyya, Arijita Sarkar, Jyotirmoy Das, Nilanjana Maji, Moitri Basu, Zhumur Ghosh, Tapash Chandra Ghosh
BACKGROUND: Human Chronic and Acute Myeloid Leukemia are myeloproliferative disorders in myeloid lineage of blood cells characterized by accumulation of aberrant white blood cells. In cancer, the anomalous transcriptome includes deregulated expression of non-coding RNAs in conjunction with protein-coding mRNAs in human genome. The coding or non-coding RNA transcripts harboring miRNA-binding sites can converse with and regulate each other by explicitly contending for a limited pool of shared miRNAs and act as competitive endogenous RNAs (ceRNAs)...
June 11, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29902176/cloud-computing-applications-for-biomedical-science-a-perspective
#6
Vivek Navale, Philip E Bourne
Biomedical research has become a digital data-intensive endeavor, relying on secure and scalable computing, storage, and network infrastructure, which has traditionally been purchased, supported, and maintained locally. For certain types of biomedical applications, cloud computing has emerged as an alternative to locally maintained traditional computing approaches. Cloud computing offers users pay-as-you-go access to services such as hardware infrastructure, platforms, and software for solving common biomedical computational problems...
June 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29901662/how-theory-can-inform-our-understanding-of-experiential-learning-in-quality-improvement-education
#7
Joanne Goldman, Ayelet Kuper, Brian M Wong
It is widely accepted that quality improvement (QI) education should be experiential. Many training programs believe that making QI learning "hands-on" through project-based learning will translate into successful learning about QI. However, this pervasive and overly simplistic interpretation of experiential QI learning, and the general lack of empirical exploration of the factors that influence experiential learning processes, may limit the overall impact of project-based learning on educational outcomes...
June 12, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29900813/importance-of-social-media-for-urologist-networking-international-resident-s-perspective
#8
EDITORIAL
José Ignacio Nolazco
No abstract text is available yet for this article.
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29899288/a-smart-collaborative-routing-protocol-for-reliable-data-diffusion-in-iot-scenarios
#9
Zheng-Yang Ai, Yu-Tong Zhou, Fei Song
It is knotty for current routing protocols to meet the needs of reliable data diffusion during the Internet of Things (IoT) deployments. Due to the random placement, limited resources and unattended features of existing sensor nodes, the wireless transmissions are easily exposed to unauthorized users, which becomes a vulnerable area for various malicious attacks, such as wormhole and Sybil attacks. However, the scheme based on geographic location is a suitable candidate to defend against them. This paper is inspired to propose a smart collaborative routing protocol, Geographic energy aware routing and Inspecting Node (GIN), for guaranteeing the reliability of data exchanging...
June 13, 2018: Sensors
https://www.readbyqxmd.com/read/29899244/the-urban-gradient-in-malaria-endemic-municipalities-in-acre-revisiting-the-role-of-locality
#10
Ana Paula Dal'Asta, Raquel Martins Lana, Silvana Amaral, Cláudia Torres Codeço, Antônio Miguel Vieira Monteiro
Urbanization has altered the distribution of diseases of public health importance along gradients of human occupation. Adopting dichotomous urban/rural categories to explain differences in the risk of exposure, as well as the prevention of diseases is insufficient. In this paper, we present the potential of representations based on the gradient perspective to characterize the living spaces of municipalities where malaria is endemic in northwest Acre. Inventoried data in 40 localities in the Mâncio Lima and Rodrigues Alves municipalities and information on land use and land cover obtained from the TerraClass Database were used to characterize the urban spatial forms and their social content...
June 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29897555/linked-4-way-multimodal-brain-differences-in-schizophrenia-in-a-large-chinese-han-population
#11
Shengfeng Liu, Haiying Wang, Ming Song, Luxian Lv, Yue Cui, Yong Liu, Lingzhong Fan, Nianming Zuo, Kaibin Xu, Yuhui Du, Qingbao Yu, Na Luo, Shile Qi, Jian Yang, Sangma Xie, Jian Li, Jun Chen, Yunchun Chen, Huaning Wang, Hua Guo, Ping Wan, Yongfeng Yang, Peng Li, Lin Lu, Hao Yan, Jun Yan, Huiling Wang, Hongxing Zhang, Dai Zhang, Vince D Calhoun, Tianzi Jiang, Jing Sui
Multimodal fusion has been regarded as a promising tool to discover covarying patterns of multiple imaging types impaired in brain diseases, such as schizophrenia (SZ). In this article, we aim to investigate the covarying abnormalities underlying SZ in a large Chinese Han population (307 SZs, 298 healthy controls [HCs]). Four types of magnetic resonance imaging (MRI) features, including regional homogeneity (ReHo) from resting-state functional MRI, gray matter volume (GM) from structural MRI, fractional anisotropy (FA) from diffusion MRI, and functional network connectivity (FNC) resulted from group independent component analysis, were jointly analyzed by a data-driven multivariate fusion method...
April 20, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29897412/mirnacancermap-an-integrative-web-server-inferring-mirna-regulation-network-for-cancer
#12
Yin Tong, Beibei Ru, Jiangwen Zhang
Summary: MicroRNAs play critical roles in oncogenesis by targeting a few key regulators or a large cohort of genes impinging on downstream signaling pathways. Conversely, miRNA activity is also titrated by ceRNA such as lncRNA with sponge effect. Web-based server, miRNACancerMap, aims to unravel lncRNA-miRNA-mRNA tripartite complexity to predict the function and clinical relevance of miRNA with network perspective. In conjunction with large-scale data and information integration, miRNACancerMap implements various algorithms and pipelines to construct dynamic miRNA-centered network with rigorous Systems Biology approaches and the state-of-the-art visualization tool...
April 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29894718/functional-neuroanatomy-of-blindsight-revealed-by-activation-likelihood-estimation-meta-analysis
#13
Alessia Celeghin, Arianna Bagnis, Matteo Diano, Andrés Méndez Guerrero, Tommaso Costa, Marco Tamietto
Blindsight, the residual abilities of patients with cortical blindness to respond proficiently to stimuli they do not consciously acknowledge, offers a unique opportunity to study the functional and anatomical mechanisms sustaining visual awareness. Over decades, the phenomenon has been documented in a wide number of different patients, across independent laboratories, and for a variety of tasks and stimulus properties. Nevertheless, the functional neuroanatomy of blindsight remains elusive and alternative proposals have been put forth...
June 9, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29894650/machine-learning-deepest-learning-as-statistical-data-assimilation-problems
#14
Henry D I Abarbanel, Paul J Rozdeba, Sasha Shirman
We formulate an equivalence between machine learning and the formulation of statistical data assimilation as used widely in physical and biological sciences. The correspondence is that layer number in a feedforward artificial network setting is the analog of time in the data assimilation setting. This connection has been noted in the machine learning literature. We add a perspective that expands on how methods from statistical physics and aspects of Lagrangian and Hamiltonian dynamics play a role in how networks can be trained and designed...
June 12, 2018: Neural Computation
https://www.readbyqxmd.com/read/29892242/dimensions-of-entrepreneurial-success-a-multilevel-study-on-stakeholders-of-micro-enterprises
#15
Wiktor Razmus, Mariola Laguna
The study provides an insight into the indicators and dimensions of entrepreneurial success as evaluated from the external stockholders' perspective. As each firm is embedded in a network of relations with stakeholders (business partners), understanding how they evaluate entrepreneurial success is important. The initial qualitative study in the form of in-depth interviews allowed us to identify the indicators of entrepreneurial success that are identified by external stakeholders of micro-firms. In the quantitative study on 475 stakeholders of 57 micro-firms, we identified the dimensions of entrepreneurial success...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29888561/-our-considerations-about-studies-on-structure-of-acupuncture-points
#16
Chen She, Dong-Sheng Xu, Jing-Jing Cui, Jia Wang, Wei He, Xiao-Yu Wang, Xiang-Hong Jing, Wan-Zhu Bai
The anatomical structure of acupuncture points is the carrier for needling stimulation induced neurobiological effects. Although researchers have never stopped investigating its structure and experienced different stages from macroscopic to microcosmic morphological material basis, our understanding still largely lags behind the requirements of the times. In the present paper, we review development of researches on acupuncture points in recent decades from 1) macroscopic anatomical structure including skin, bones, muscles, nerves, blood vessels, etc...
May 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29888005/the-impact-of-quality-of-life-on-the-health-of-older-people-from-a-multidimensional-perspective
#17
Luis Miguel Rondón García, Jose Manuel Ramírez Navarrro
Background: This research analyzes the impact of quality of life as a metavariable that conditions the health and social welfare of the elderly. The sample of this study is composed of 500 people, randomly selected from the major day centers for the elderly in the province of Granada (Spain). Method: For the inferential analysis, we used the CUBRECAVI questionnaire, which is a multidimensional scale of health and quality of life, along with the Katz and García measure questionnaires, which are also applied to quality of life...
2018: Journal of Aging Research
https://www.readbyqxmd.com/read/29885784/making-psychiatric-semiology-great-again-a-semiologic-not-nosologic-challenge
#18
J-A Micoulaud-Franchi, C Quiles, J-M Batail, C Lancon, M Masson, G Dumas, M Cermolacce
This article analyzes whether psychiatric disorders can be considered different from non-psychiatric disorders on a nosologic or semiologic point of view. The supposed difference between psychiatric and non-psychiatric disorders relates to the fact that the individuation of psychiatric disorders seems more complex than for non-psychiatric disorders. This individuation process can be related to nosologic and semiologic considerations. The first part of the article analyzes whether the ways of constructing classifications of psychiatric disorders are different than for non-psychiatric disorders...
June 6, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29883789/selenium-at-the-redox-interface-of-the-genome-metabolome-and-exposome
#19
REVIEW
Jolyn Fernandes, Xin Hu, M Ryan Smith, Young-Mi Go, Dean P Jones
Selenium (Se) is a redox-active environmental mineral that is converted to only a small number of metabolites and required for a relatively small number of mammalian enzymes. Despite this, dietary and environmental Se has extensive impact on every layer of omics space. This highlights a need for global network response structures to provide reference for targeted, hypothesis-driven Se research. In this review, we survey the Se research literature from the perspective of the responsive physical and chemical barrier between an organism (functional genome) and its environment (exposome), which we have previously termed the redox interface...
June 5, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29883437/under-the-same-sky-connecting-students-and-cultures-through-circumpolar-nursing-education
#20
Bente Norbye, Lorna Butler, Heather Exner-Pirot
The recruitment and retention of health professionals in rural, remote, and northern regions is an ongoing challenge. The Northern Nursing Education Network brought together nursing students working in rural and remote regions of the circumpolar north in Innovative Learning Institute on Circumpolar Health (ILICH) events to create opportunities for shared learning and expose both students and faculty to local and traditional knowledge that informs health behaviors specific to regions with Indigenous populations...
May 21, 2018: Healthcare (Basel, Switzerland)
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