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https://www.readbyqxmd.com/read/29238770/molecular-cocrystals-design-charge-transfer-and-optoelectronic-functionality
#1
Lingjie Sun, Weigang Zhu, Fangxu Yang, Baili Li, Xiaochen Ren, Xiaotao Zhang, Wenping Hu
Organic cocrystals, formed by a combination of electron-rich donors and electron-poor acceptors, play an important role in tailoring the optoelectronic properties of molecular materials. Charge transfer interactions in cocrystals not only endow them with an ordered three-dimensional (3D) supramolecular network in different constituent units, but also render them ideal scaffolds to control the intermolecular interactions in multicomponent solids. In this perspective, we firstly introduce preparation methods, molecular packing modes and charge transfer in organic cocrystals...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29237552/female-songbirds-the-unsung-drivers-of-courtship-behavior-and-its-neural-substrates
#2
REVIEW
Ammon Perkes, David White, Martin Wild, Marc Schmidt
Songbirds hold a prominent role in the fields of neurobiology, evolution, and social behavior. Many of these fields have assumed that females lacked the ability to produce song and have therefore treated song as a male-specific behavior. Consequently, much of our understanding regarding the evolution and neural control of song behavior has been driven by these assumptions. Here we review literature from diverse fields to provide a broader perspective of the role of females in vocal communication and courtship...
December 10, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29235372/strengthening-stakeholder-involvement-in-health-workforce-governance-why-we-need-to-talk-about-power
#3
Ellen Kuhlmann, Viola Burau
There is now widespread agreement on the benefits of an integrated, people-centred health workforce, but the implementation of new models is difficult. We argue that we need to think about stakeholders and power, if we want to ensure change in the health workforce. We discuss these issues from a governance perspective and suggest a critical approach to stakeholder involvement as an indicator of good governance. Three models of involving stakeholders in health workforce governance can be identified: corporatist professional involvement either in a continental European model of conservative corporatism or in a Nordic model of public corporatism; managerialist and market-centred involvement of professions as organizational agents; and a more inclusive, network-based involvement of plural professional experts at different levels of governance...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29233447/reflections-on-a-year-long-student-and-pharmacist-paired-mentorship-program
#4
Rashi C Waghel, Jennifer A Wilson, Dawn M Battise, Jared Frye
BACKGROUND AND PURPOSE: Mentorship programs can play a significant role in the professional development of a variety of individuals, including student pharmacists and practitioners. Many mentorship programs have been described in the literature, but the literature pertaining to mentorship programs for student pharmacists specifically is varied. EDUCATIONAL ACTIVITY AND SETTING: A leadership society at one school of pharmacy established a formal mentorship program to aid the professional development of student pharmacists...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233185/phosphoproteomics-reveals-network-rewiring-to-a-pro-adhesion-state-in-annexin-1-deficient-mammary-epithelial-cells
#5
Asfa Alli-Shaik, Sheena Wee, Lina H K Lim, Jayantha Gunaratne
BACKGROUND: Annexin-1 (ANXA1) plays pivotal roles in regulating various physiological processes including inflammation, proliferation and apoptosis, and deregulation of ANXA1 functions has been associated with tumorigenesis and metastasis events in several types of cancer. Though ANXA1 levels correlate with breast cancer disease status and outcome, its distinct functional involvement in breast cancer initiation and progression remains unclear. We hypothesized that ANXA1-responsive kinase signaling alteration and associated phosphorylation signaling underlie early events in breast cancer initiation events and hence profiled ANXA1-dependent phosphorylation changes in mammary gland epithelial cells...
December 12, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29232902/rapid-assessment-of-stakeholder-concerns-about-public-health-an-introduction-to-a-fast-and-inexpensive-approach-applied-on-health-concerns-about-intensive-animal-production-systems
#6
Marleen Kraaij-Dirkzwager, Joost van der Ree, Erik Lebret
To effectively manage environmental health risks, stakeholders often need to act collectively. Stakeholders vary in their desire to act due to many factors, such as knowledge, risk perception, interests, and worldviews. Understanding their perceptions of the issues at stake is crucial to support the risk governance process. Even though concern assessment is a pivotal element of risk governance, few tools for rapid assessment are reported in the literature. We tested a rapid and relatively cheap approach, taking the Dutch debate on Intensive Animal Production Systems (IAPS) and health as an example...
December 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29224844/social-management-of-laboratory-rhesus-macaques-housed-in-large-groups-using-a-network-approach-a-review
#7
Brenda McCowan, Brianne Beisner, Darcy Hannibal
Biomedical facilities across the nation and worldwide aim to develop cost-effective methods for the reproductive management of macaque breeding groups, typically by housing macaques in large, multi-male multi-female social groups that provide monkey subjects for research as well as appropriate socialization for their psychological well-being. One of the most difficult problems in managing socially housed macaques is their propensity for deleterious aggression. From a management perspective, deleterious aggression (as opposed to less intense aggression that serves to regulate social relationships) is undoubtedly the most problematic behavior observed in group-housed macaques, which can readily escalate to the degree that it causes social instability, increases serious physical trauma leading to group dissolution, and reduces psychological well-being...
December 7, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29223686/nourishing-networks-a-social-ecological-analysis-of-a-network-intervention-for-improving-household-nutrition-in-western-kenya
#8
Autumn L DeLorme, Erika R Gavenus, Charles R Salmen, Gor Ouma Benard, Brian Mattah, Elizabeth Bukusi, Kathryn J Fiorella
RATIONALE: A growing body of research emphasizes the need to engage social networks in maternal and child nutrition interventions. However, an understanding of how interventions functionally engage not only mothers but fathers, grandparents, friends, and other social network members remains limited. OBJECTIVE: This study uses an adaptation of a social-ecological model to analyze the multiple levels at which the Kanyakla Nutrition Program operates to change behavior...
November 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29223199/the-influence-of-homophilous-interactions-on-diversity-effects-in-group-problem-solving
#9
Claudia P Estévez-Mujica, Andrés Acero, William Jiménez-Leal, César Garcia-Diaz
Increasingly diversity researchers call for further studies of group micro-processes and dynamics to understand the paradoxical effects of diversity on group performance. In this study, based on analyses of in-group, networked, homophilous interactions, we aim to explain further the effects of diversity on group performance in a parallel problem-solving task, both experimentally and computationally. We developed a 'whodunit' problem-solving experiment with 116 participants assigned to different-sized groups...
January 2018: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/29222835/effective-network-of-deep-brain-stimulation-of-subthalamic-nucleus-with-bimodal-positron-emission-tomography-functional-magnetic-resonance-imaging-in-parkinson-s-disease
#10
Hui-Min Chen, Zhi-Qiang Sha, Hui-Zi Ma, Yong He, Tao Feng
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood. METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease...
December 8, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29222764/optimization-of-multi-omic-genome-scale-models-methodologies-hands-on-tutorial-and-perspectives
#11
Supreeta Vijayakumar, Max Conway, Pietro Lió, Claudio Angione
Genome-scale metabolic models are valuable tools for assessing the metabolic potential of living organisms. Being downstream of gene expression, metabolism is increasingly being used as an indicator of the phenotypic outcome for drugs and therapies. We here present a review of the principal methods used for constraint-based modelling in systems biology, and explore how the integration of multi-omic data can be used to improve phenotypic predictions of genome-scale metabolic models. We believe that the large-scale comparison of the metabolic response of an organism to different environmental conditions will be an important challenge for genome-scale models...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222457/a-control-analysis-perspective-on-katz-centrality
#12
Kieran J Sharkey
Methods for efficiently controlling dynamics propagated on networks are usually based on identifying the most influential nodes. Knowledge of these nodes can be used for the targeted control of dynamics such as epidemics, or for modifying biochemical pathways relating to diseases. Similarly they are valuable for identifying points of failure to increase network resilience in, for example, social support networks and logistics networks. Many measures, often termed 'centrality', have been constructed to achieve these aims...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29218871/extracting-a-biologically-relevant-latent-space-from-cancer-transcriptomes-with-variational-autoencoders
#13
Gregory P Way, Casey S Greene
The Cancer Genome Atlas (TCGA) has profiled over 10,000 tumors across 33 different cancer-types for many genomic features, including gene expression levels. Gene expression measurements capture substantial information about the state of each tumor. Certain classes of deep neural network models are capable of learning a meaningful latent space. Such a latent space could be used to explore and generate hypothetical gene expression profiles under various types of molecular and genetic perturbation. For example, one might wish to use such a model to predict a tumor's response to specific therapies or to characterize complex gene expression activations existing in differential proportions in different tumors...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29217127/epigenome-in-early-mammalian-development-inheritance-reprogramming-and-establishment
#14
REVIEW
Qianhua Xu, Wei Xie
Drastic epigenetic reprogramming takes place during preimplantation development, leading to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in remodeling of the epigenomes can cause severe developmental defects, including embryonic lethality. However, how chromatin modifications and chromatin organization are reprogrammed upon fertilization in mammals has long remained elusive. Here, we review recent progress in understanding how the epigenome is dynamically regulated during early mammalian development...
December 4, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/29216593/phosphorus-and-nitrogen-limitation-and-impairment-of-headwater-streams-relative-to-rivers-in-great-britain-a-national-perspective-on-eutrophication
#15
Helen P Jarvie, Douglas R Smith, Lisa R Norton, Francois K Edwards, Michael J Bowes, Stephen M King, Peter Scarlett, Sian Davies, Rachael M Dils, Nuria Bachiller-Jareno
This study provides a first national-scale assessment of the nutrient status of British headwater streams within the wider river network, by joint analysis of the national Countryside Survey Headwater Stream and Harmonised River Monitoring Scheme datasets. We apply a novel Nutrient Limitation Assessment methodology to explore the extent to which nutrients may potentially limit primary production in headwater streams and rivers, by coupling ternary assessment of nitrogen (N), phosphorus (P), and carbon (C) depletion, with N:P stoichiometry, and threshold P and N concentrations...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29214566/improved-diagnosis-and-care-for-rare-diseases-through-implementation-of-precision-public-health-framework
#16
Gareth Baynam, Faye Bowman, Karla Lister, Caroline E Walker, Nicholas Pachter, Jack Goldblatt, Kym M Boycott, William A Gahl, Kenjiro Kosaki, Takeya Adachi, Ken Ishii, Trinity Mahede, Fiona McKenzie, Sharron Townshend, Jennie Slee, Cathy Kiraly-Borri, Anand Vasudevan, Anne Hawkins, Stephanie Broley, Lyn Schofield, Hedwig Verhoef, Tudor Groza, Andreas Zankl, Peter N Robinson, Melissa Haendel, Michael Brudno, John S Mattick, Marcel E Dinger, Tony Roscioli, Mark J Cowley, Annie Olry, Marc Hanauer, Fowzan S Alkuraya, Domenica Taruscio, Manuel Posada de la Paz, Hanns Lochmüller, Kate Bushby, Rachel Thompson, Victoria Hedley, Paul Lasko, Kym Mina, John Beilby, Cynthia Tifft, Mark Davis, Nigel G Laing, Daria Julkowska, Yann Le Cam, Sharon F Terry, Petra Kaufmann, Iiro Eerola, Irene Norstedt, Ana Rath, Makoto Suematsu, Stephen C Groft, Christopher P Austin, Ruxandra Draghia-Akli, Tarun S Weeramanthri, Caron Molster, Hugh J S Dawkins
Public health relies on technologies to produce and analyse data, as well as effectively develop and implement policies and practices. An example is the public health practice of epidemiology, which relies on computational technology to monitor the health status of populations, identify disadvantaged or at risk population groups and thereby inform health policy and priority setting. Critical to achieving health improvements for the underserved population of people living with rare diseases is early diagnosis and best care...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29213124/the-ra-map-consortium-a-working-model-for-academia-industry-collaboration
#17
REVIEW
Andrew P Cope, Michael R Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A Fisher, Carl S Goodyear, Paul Emery, Michael R Ehrenstein, Neil Gozzard, Ray Harris, Sally Hollis, Sarah Keidel, Marc Levesque, Catharina Lindholm, Michael F McDermott, Iain B McInnes, Christopher M Mela, Gerry Parker, Simon Read, Ayako Wakatsuki Pedersen, Frederique Ponchel, Duncan Porter, Ravi Rao, Anthony Rowe, Peter Schulze-Knappe, Matthew A Sleeman, Deborah Symmons, Peter C Taylor, Brian Tom, Wayne Tsuji, Denny Verbeeck, John D Isaacs
Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing and fostering new research consortia. This model has percolated down to national funding agencies across the globe, leading to funding for projects that aim to realise the true potential of genomic medicine in the 21st century and to reap the rewards of 'big data'...
December 7, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29211178/a-wave-that-comes-rushing-in-and-dunks-you-representations-and-destinies-of-the-crisis-in-adolescent-users-of-a-capsi
#18
Melissa de Oliveira Pereira, Marilene de Castilho Sá, Lilian Miranda
This article focuses on the inter-subjective aspects involved in the care of psychosocial crises of adolescents, their representations and developments. A qualitative research was developed from a psycho-sociological perspective by constructing life story narratives of adolescents treated at a Psychosocial Care Center for Children and Adolescents (CAPSi). It was based on the theoretical contributions of René Kaës on group and cultural aspects of the crisis, as well as its relation to adolescence. Life narratives, constructed through in-depth interviews with adolescents, close relatives, and CAPSi caretakers depict crisis as a "surprise", as violence and estrangement, an episode that must be forgotten, denied, silenced, and medicalized...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29208988/similarity-based-regularized-latent-feature-model-for-link-prediction-in-bipartite-networks
#19
Wenjun Wang, Xue Chen, Pengfei Jiao, Di Jin
Link prediction is an attractive research topic in the field of data mining and has significant applications in improving performance of recommendation system and exploring evolving mechanisms of the complex networks. A variety of complex systems in real world should be abstractly represented as bipartite networks, in which there are two types of nodes and no links connect nodes of the same type. In this paper, we propose a framework for link prediction in bipartite networks by combining the similarity based structure and the latent feature model from a new perspective...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205242/refining-tools-to-bridge-the-gap-between-academia-and-chemical-regulation-perspectives-for-wikireach
#20
Marlene Ågerstrand, Mattheus Brenig, Martin Führ, Julian Schenten
Regulatory hazard and risk assessments of chemical substances have to include all reliable and relevant data to be credible and complete. However, screening the literature for appropriate studies and extracting data is burdensome. Therefore, reducing impediments by making data easily and readily accessible to risk assessors could result in more comprehensive hazard and risk assessments. In this paper, we study WikiPharma, a database that aggregates ecotoxicity data for pharmaceuticals, extracted from peer-reviewed studies...
December 5, 2017: Environmental Science. Processes & Impacts
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