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https://www.readbyqxmd.com/read/29055095/the-joint-effects-of-major-lifestyle-factors-on-colorectal-cancer-risk-among-chinese-men-a-prospective-cohort-study
#1
Qing-Li Zhang, Long-Gang Zhao, Hong-Lan Li, Jing Gao, Gong Yang, Jing Wang, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang
Previous studies have suggested individual healthy lifestyle factors are related to lower risk of colorectal cancer. Their joint effects, however, have rarely been investigated. We aimed to assess the combined lifestyle impact on colorectal cancer risk and to estimate the population attributable risks of these lifestyle factors. Using data from the Shanghai Men's Health Study (2002-2013), we constructed healthy lifestyle index composing the following lifestyle factors: smoking, alcohol consumption, diet, waist-hip ratio and exercise participation...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29055075/association-between-genetic-polymorphisms-and-pain-sensitivity-in-patients-with-hip-osteoarthritis
#2
Anne E Olesen, Lecia M Nielsen, Søren Feddersen, Joachim Erlenwein, Frank Petzke, Michael Przemeck, Lona L Christrup, Asbjørn M Drewes
BACKGROUND: Factors such as age, gender and genetic polymorphisms may explain individual difference in pain phenotype. Genetic associations to pain sensitivity have previously been investigated in osteoarthritis patients with focus on the P2X7, TRPV1 and TACR1 genes. However, other genes may play a role as well. Osteoarthritis is a common joint disease and many patients suffering from this disease are thought to have increased sensitivity to noxious stimuli resulting from sensitization in the nociceptive system...
October 20, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29055024/serum-lipid-vitamin-d-levels-and-obesity-in-perimenopausal-and-postmenopausal-women-in-non-manual-employment
#3
Jarosław Pinkas, Iwona Bojar, Mariusz Gujski, Joanna Bartosińska, Alfred Owoc, Dorota Raczkiewicz
BACKGROUND Increasing age, increased body mass index (BMI), and abnormal lipid profiles contribute to an increased risk of vitamin D deficiency. Women who have a perimenopausal and postmenopausal reduction in estrogen levels are a high-risk group for vitamin D deficiency. The aims of this study were to compare the serum vitamin D levels, lipid profile, and BMI between perimenopausal and postmenopausal women in non-manual employment, and to determine whether there were any interdependent factors. MATERIAL AND METHODS Three hundred women in non-manual employment, aged between 44-66 years, were divided into three groups: early perimenopausal; late perimenopausal; and postmenopausal...
October 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29054991/the-influence-of-bone-mineral-density-and-cortical-index-on-the-complexity-of-fractures-of-the-proximal-humerus
#4
J W A M den Teuling, B S Pauwels, L Janssen, C E Wyers, H M J Janzing, J P W van den Bergh, J W Morrenhof
OBJECTIVES: The goal of this study is to investigate the relation between indicators of osteoporosis (i.e., bone mineral density (BMD), and Cortical Index (CI)) and the complexity of a fracture of the proximal humerus as a result of a low-energy trauma. METHODS: A retrospective chart review of 168 patients (mean age 67.2 years, range 51 to 88.7) with a fracture of the proximal humerus between 2007 and 2011, whose BMD was assessed at the Fracture Liaison Service with Dual Energy X-ray Absorptiometry (DXA) measurements of the hip, femoral neck (FN) and/or lumbar spine (LS), and whose CI and complexity of fracture were assessed on plain anteroposterior radiographs of the proximal humerus...
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29054726/a-comparison-of-walking-gait-following-mechanical-and-kinematic-alignment-in-total-knee-joint-replacement
#5
Peter J McNair, Mark G Boocock, Nicholas D Dominick, Richard J Kelly, Bill J Farrington, Simon W Young
BACKGROUND: Although previous studies have compared radiological, pain, and function scores in kinematically aligned (KA) and mechanically aligned (MA) total knee arthroplasty (TKA), no previous studies have undertaken a three-dimensional (3D) gait analysis in these groups. This study compared kinematic and kinetic variables recorded during level walking in patients at least 2 years post-surgery who underwent an MA or KA procedure. METHODS: Utilizing a 9-camera motion analysis system, gait analysis was undertaken on 29 patients (MA = 15, KA = 14)...
September 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29054559/the-influence-of-reconstruction-kernel-on-bone-mineral-and-strength-estimates-using-quantitative-computed-tomography-and-finite-element-analysis
#6
Andrew S Michalski, W Brent Edwards, Steven K Boyd
Quantitative computed tomography has been posed as an alternative imaging modality to investigate osteoporosis. We examined the influence of computed tomography convolution back-projection reconstruction kernels on the analysis of bone quantity and estimated mechanical properties in the proximal femur. Eighteen computed tomography scans of the proximal femur were reconstructed using both a standard smoothing reconstruction kernel and a bone-sharpening reconstruction kernel. Following phantom-based density calibration, we calculated typical bone quantity outcomes of integral volumetric bone mineral density, bone volume, and bone mineral content...
October 17, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29054483/risk-and-associates-of-incident-hip-fracture-in-type-1-diabetes-the-fremantle-diabetes-study
#7
Emma J Hamilton, Wendy A Davis, David G Bruce, Timothy M E Davis
AIMS: To determine the relative risk of incident hip fracture in patients with type 1 diabetes and matched controls, to examine baseline associates of incident hip fracture in the patients with type 1 diabetes, and to compare hip fracture rates in age- and sex- matched patients with type 1 versus type 2 diabetes. METHODS: Longitudinal observational study of 121 adults with type 1 diabetes (mean±SD age 43.0±15.5 years, 59.5% male) and 484 age- and sex-matched adults without diabetes...
October 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29054430/nmda-receptor-dependent-changes-in-c-fos-and-p-creb-signaling-following-extinction-and-reinstatement-of-morphine-place-preference
#8
Ali Siahposht-Khachaki, Somayeh Ezzatpanah, Yasaman Razavi, Abbas Haghparast
Neural circuitry comprising the ventral tegmental area, nucleus accumbens (NAc), prefrontal cortex (PFC) and hippocampus (HIP) has a main role in reward phenomena. Previous behavioral studies indicated that intracerebroventricular administration of AP5 (NMDA glutamate receptor antagonist) and CNQX (AMPA/kainate glutamate receptor antagonist) during the extinction and before reinstatement of morphine-induced conditioned place preference (CPP) reduced the extinction period and reinstatement of morphine-CPP. Therefore, in the present study, we tried to evaluate the effect of antagonism of NMDA glutamate receptors on the p-CREB/CREB ratio and c-fos expression in the NAc, PFC and HIP during these two phases of morphine-CPP in male adult albino Wistar rats...
October 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29054327/sex-differences-in-anticipatory-postural-adjustments-during-rapid-single-leg-lift
#9
Melanie D Bussey, Marcelo Peduzzi de Castro, Daniela Aldabe, Jonathan Shemmell
The aim of this study was to assess the influence of sex on the kinetic, kinematic and neuromuscular correlates of anticipatory postural adjustments (APAs) during a single leg lift task performed by healthy participants. Fifty healthy age and body mass index matched participants (25 women and 25 men) performed 20 single leg lift task (hip flexion to 90 ° as quickly as possible) with their dominant and their non-dominant lower limbs. A force plate was used to determine the medial-lateral displacement of the center of pressure (COPML), and the initiation of weight shift (T0); kinematics was used to determine leg lift (T1); and electromyography was used to determine onset times from eight muscles: bilateral external oblique, internal oblique and lumbar multifidus, and unilateral (stance limb) gluteus maximus and biceps femoris...
October 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29054175/effect-of-roux-en-y-gastric-bypass-on-thyroid-function-in-euthyroid-patients-with-obesity-and-type-2-diabetes
#10
Fangyuan Liu, Jianzhong Di, Haoyong Yu, Junfeng Han, Yuqian Bao, Weiping Jia
BACKGROUND: The impact of bariatric surgery on thyroid hormone levels is poorly understood. OBJECTIVES: To investigate changes in serum-free thyroxine (FT4) and thyroid-stimulating hormone (TSH) after Roux-en-Y gastric bypass (RYGB) in euthyroid patients with obesity and type 2 diabetes. SETTING: University Hospital, China. METHODS: Eighty-one euthyroid Chinese patients with obesity and type 2 diabetes who underwent RYGB, and 20 healthy volunteers were enrolled in this retrospective study...
October 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29052797/suppressive-antibiotic-therapy-with-oral-tetracyclines-for-prosthetic-joint-infections-a-retrospective-study-of-78-patients
#11
M Pradier, O Robineau, A Boucher, M Titecat, N Blondiaux, M Valette, C Loïez, E Beltrand, S Nguyen, H Dézeque, H Migaud, Eric Senneville
PURPOSE: This study aimed at describing the use of oral cyclines (i.e., doxycycline and minocycline) as suppressive antibiotic therapy (SAT) in patients with periprosthetic joint infections (PJIs). METHODS: Medical charts of all patients with surgical revisions for PJIs who were given cycline-based SAT because of a high failure of various origins were reviewed. Data regarding tolerability and effectiveness of cycline-based SAT were analysed. RESULTS: Seventy-eight patients of mean age 64 ± 17 years received cycline-base SAT in the period from January 2006 to January 2014...
October 20, 2017: Infection
https://www.readbyqxmd.com/read/29052793/comparison-of-fracture-risk-assessment-tools-in-older-men-without-prior-hip-or-spine-fracture-the-mros-study
#12
Margaret L Gourlay, Victor S Ritter, Jason P Fine, Robert A Overman, John T Schousboe, Peggy M Cawthon, Eric S Orwoll, Tuan V Nguyen, Nancy E Lane, Steven R Cummings, Deborah M Kado, Jodi A Lapidus, Susan J Diem, Kristine E Ensrud
Femoral neck bone mineral density (BMD), age plus femoral neck BMD T score, and three externally generated fracture risk tools had similar accuracy to identify older men who developed osteoporotic fractures. Risk tools with femoral neck BMD performed better than those without BMD. The externally developed risk tools were poorly calibrated. INTRODUCTION: We compared the performance of fracture risk assessment tools in older men, accounting for competing risks including mortality. METHODS: A comparative ROC curve analysis assessed the ability of the QFracture, FRAX® and Garvan fracture risk tools, and femoral neck bone mineral density (BMD) T score with or without age to identify incident fracture in community-dwelling men aged 65 years or older (N = 4994) without hip or clinical vertebral fracture or antifracture treatment at baseline...
October 20, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29051986/the-relationship-between-fatty-liver-index-and-bone-mineral-density-in-koreans-knhanes-2010-2011
#13
S H Ahn, D H Seo, S H Kim, M-S Nam, S Hong
Analyses using a nationally representative cohort have revealed that high fatty liver index (FLI) is associated with low bone mineral density (BMD) regardless of insulin resistance in men, thereby supporting the deteriorated bone metabolism in nonalcoholic fatty liver disease (NAFLD). INTRODUCTION: NAFLD is linked to deteriorated bone health. We investigated the association of FLI, a scoring model for NAFLD, with BMD. METHODS: This was a population-based, cross-sectional study from the Korea National Health and Nutrition Examination Surveys including 4264 Koreans (1908 men and 2356 women)...
October 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29051886/longest-known-follow-up-of-a-hip-arthroplasty-the-last-chapter-of-a-65-year-long-story
#14
Tamas Halasi, Declan Reidy, Shane Guerin
INTRODUCTION: The Smith-Petersen vitallium mold arthroplasty was a real landmark in arthroplasty surgery as this was the first technique which produced predictable and satisfactory results. CASE REPORT: We present the longest known follow-up of any hip arthroplasty in literature. The arthroplasty was performed in 1949 in London on a 30-years-old female patient with congenital hip dysplasia, and it was revised in 2014 after 65 years. CONCLUSION: Total hip arthroplasties nowadays give better functional results, but the fact that the patient got 65 years of the relatively good function is noteworthy and is a tribute to Dr...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051879/the-destructive-power-of-circumstance-on-concurrent-poliomyelitis-and-osteomyelitis
#15
Delran Anandkumar, Ananthakrishnan Raghupathi, Ragai Gadelrab
INTRODUCTION: The current method in dealing with pediatric hip pathologies is to avoid joint replacement unless absolutely necessary. This decision is typically made on a scientific basis. However, this is not necessarily the correct approach in all cases as demonstrated in the following case report where social issues is an extremely important variable to be considered when deciding on surgical intervention. CASE REPORT: This case report is the first of its kind to highlight the pathology mentioned and the social determinants that were a causative agent in its development...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051877/a-case-of-non-traumatic-avascular-necrosis-of-femur-in-case-of-transfusion-dependent-thalassemia
#16
Geeta Mandhani, Manas Kalra, Ramani Narasimhan, V K Khanna, Amita Mahajan
INTRODUCTION: Avascular necrosis of the head of femur (AVNF) has frequently been reported with sickle cell anemia but is not commonly associated with beta thalassemia. CASE REPORT: We report a case of 14-year-old male with transfusion-dependent thalassemia (TDT) and hepatitis C, who developed bilateral atraumatic AVNF requiring surgical correction. The likely etiopathogenesis and the review of literature for this uncommon finding are discussed. CONCLUSION: AVNF should be considered as a possibility in a patient with TDT presenting with hip pain...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051876/transient-migratory-osteoporosis-of-the-hip-and-talus-a-case-report
#17
Raju Vaishya, Amit Kumar Agarwal, Vipul Vijay, Abhishek Vaish
INTRODUCTION: Transient migratory osteoporosis (TMO) is a rare and self-limiting condition of unknown etiology. The hip joint is the most common joint to get involved in this disease followed by a knee, ankle, and foot. CASE REPORT: We report a case, which illustrates the importance of recognizing the typical clinical and radiological features of TMO of the hip and ankle, thereby allowing an appropriate form of treatment. Spontaneous resolution of symptoms occurred in the patient...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051875/undisplaced-intraoperative-fracture-presenting-as-early-dislocation-with-tapered-wedge-stems-in-total-hip-arthroplasty-case-series-and-review-of-literature
#18
A V Gurava Reddy, Krishna Kiran Eachempati, Aakash Mugalur, A Suchinder, V B N Prasad Rao, Nalanda Kamurukuru
INTRODUCTION: Periprosthetic fractures and dislocation in the early post-operative period can be disastrous both for the surgeon and the patient. However, undisplaced periprosthetic fractures presenting with dislocation is uncommon. We describe successful management of two cases (one bilateral dislocation and one unilateral dislocation) of undisplaced iatrogenic fractures in total hip arthroplasty (THA) presenting as early dislocation. CASE REPORT: Case 1 was a 45-year-old female with osteoarthritis of hip secondary to developmental dysplasia of the hip with bilateral early nontraumatic dislocation with bilateral identical periprosthetic fracture...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29050958/metal-artefact-reduction-for-accurate-tumour-delineation-in-radiotherapy
#19
David Gergely Kovacs, Laura A Rechner, Ane L Appelt, Anne K Berthelsen, Junia C Costa, Jeppe Friborg, Gitte F Persson, Jens Peter Bangsgaard, Lena Specht, Marianne C Aznar
BACKGROUND AND PURPOSE: Two techniques for metal artefact reduction for computed tomography were studied in order to identify their impact on tumour delineation in radiotherapy. MATERIALS AND METHODS: Using specially designed phantoms containing metal implants (dental, spine and hip) as well as patient images, we investigated the impact of two methods for metal artefact reduction on (A) the size and severity of metal artefacts and the accuracy of Hounsfield Unit (HU) representation, (B) the visual impact of metal artefacts on image quality and (C) delineation accuracy...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29050822/a-comparison-and-update-of-direct-kinematic-kinetic-models-of-leg-stiffness-in-human-running
#20
Bernard X W Liew, Susan Morris, Ashleigh Masters, Kevin Netto
Direct kinematic-kinetic modelling currently represents the "Gold-standard" in leg stiffness quantification during three-dimensional (3D) motion capture experiments. However, the medial-lateral components of ground reaction force and leg length have been neglected in current leg stiffness formulations. It is unknown if accounting for all 3D would alter healthy biologic estimates of leg stiffness, compared to present direct modelling methods. This study compared running leg stiffness derived from a new method (multiplanar method) which includes all three Cartesian axes, against current methods which either only include the vertical axis (line method) or only the plane of progression (uniplanar method)...
October 6, 2017: Journal of Biomechanics
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