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Stephan Windecker

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https://www.readbyqxmd.com/read/29786535/evaluating-the-importance-of-sham-controlled-trials-in-the-investigation-of-medical-devices-in-interventional-cardiology
#1
Robert A Byrne, Davide Capodanno, Felix Mahfoud, Jean Fajadet, Stephan Windecker, Peter Jüni, Andreas Baumbach, William Wijns, Michael Haude
Cardiovascular medicine is one of the specialties that has relied most heavily on evidence from randomized clinical trials in determining best practice for the management of common disease conditions. When comparing treatment approaches, trials incorporating random allocation are the most appropriate method for protecting against treatment allocation bias. In order to protect against performance and ascertainment bias, trial designs including placebo control are preferable where feasible. In contrast to testing of medicines, treatments based on procedures or use of medical devices are more challenging to assess, as sham procedures are necessary to facilitate blinding of participants...
May 22, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29769167/impact-of-sex-on-comparative-outcomes-of-bivalirudin-versus-unfractionated-heparin-in-patients-with-acute-coronary-syndromes-undergoing-invasive-management-a-pre-specified-analysis-of-the-matrix-trial
#2
Giuseppe Gargiulo, Bruno R da Costa, Enrico Frigoli, Cataldo Palmieri, Marco Stefano Nazzaro, Camillo Falcone, Armando Liso, Carlo Vigna, Fabio Abate, Marco Comeglio, Roberto Diletti, Gabriele Gabrielli, Emilio Di Lorenzo, Pietro Mazzarotto, Marco Zimarino, Claudio Moretti, Antonio Colombo, Carlo Penzo, Giampaolo Pasquetto, Salvatore Brugaletta, Fabio Ferrari, Gavino Casu, Vincenzo Guiducci, Antonio Dellavalle, Francesco Liistro, Ciro Mauro, Arnoud W J Van't Hof, Elmir Omerovic, Salvatore Curello, Jose Maria de la Torre Hernandez, Stefano De Servi, Flavia Belloni, Stephan Windecker, Marco Valgimigli
AIMS: To assess whether bivalirudin compared with unfractionated heparin (UFH) is associated with consistent outcomes in male and female patients with acute coronary syndrome (ACS) undergoing invasive management. METHODS AND RESULTS: In the MATRIX program,7213 patients were randomized to bivalirudin or UFH.Patients in bivalirudin group were subsequently assigned to receive or not to receive a post-PCI infusion.The 30-day coprimary outcomes were major adverse cardiovascular and cerebrovascular events (MACE),defined as death,myocardial infarction,or stroke,and net adverse clinical events (NACE),defined as MACE or major bleeding...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29748219/frequency-reasons-and-impact-of-premature-ticagrelor-discontinuation-in-patients-undergoing-coronary-revascularization-in-routine-clinical-practice-results-from-the-bern-percutaneous-coronary-intervention-registry
#3
Thomas Zanchin, Fabrice Temperli, Alexios Karagiannis, Christian Zanchin, Markus Räsänen, Konstantinos C Koskinas, Stefan Stortecky, Lukas Hunziker, Fabien Praz, Stefan Blöchlinger, Christina Moro, Aris Moschovitis, Christian Seiler, Michael Billinger, Dik Heg, Thomas Pilgrim, Marco Valgimigli, Stephan Windecker, Lorenz Räber
BACKGROUND: Although ticagrelor has improved clinical outcomes among patients with acute coronary syndrome compared with clopidogrel, adherence to this new antiplatelet agent in real-world practice has not been fully investigated. METHODS AND RESULTS: Between November 2011 and June 2014, 1278 of 4831 consecutive patients (26.5%) undergoing percutaneous coronary intervention at a tertiary care center were treated with ticagrelor. Premature ticagrelor cessation was categorized into (1) change, when ticagrelor was replaced by prasugrel; (2) de-escalation, when ticagrelor was replaced by clopidogrel; and (3) premature discontinuation, when ticagrelor was discontinued without P2Y12 inhibitor replacement...
May 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29741486/computed-tomography-based-oversizing-and-incidence-of-para-valvular-aortic-regurgitation-and-permanent-pacemaker-implantation-with-a-new-generation-self-expanding-transcatheter-heart-valve
#4
Ung Kim, Philipp Blanke, Stephan Windecker, Albert M Kasel, Ulrich Schäfer, Darren Walters, Axel Linke, Herve Le Breton, Gerhard Schymik, Mark S Spence, Lars Sondergaard, Mohammed Abdel-Wahab, Stephen Worthley, Didier Tchetche, Hermann Reichenspurner, Mickael Ohana, Stephanie L Sellers, Jonathon A Leipsic
AIMS: We aimed to evaluate the relationship between CT-based annular perimeter oversizing and the incidence of paravalvular aortic regurgitation (PAR) and permanent pacemaker (PPM) implantation in patients treated with the new self-expanding CENTERA transcatheter heart valve (THV) for severe aortic stenosis. METHODS AND RESULTS: 198 patients in the CENTERA-EU trial were stratified priori into four groups based on the perimeter oversizing (2.5%-10%, 10-15%, 15-20% and >20%)...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29730991/feasibility-of-cardiovascular-magnetic-resonance-to-detect-oxygenation-deficits-in-patients-with-multi-vessel-coronary-artery-disease-triggered-by-breathing-maneuvers
#5
Kady Fischer, Kyohei Yamaji, Silvia Luescher, Yasushi Ueki, Bernd Jung, Hendrik von Tengg-Kobligk, Stephan Windecker, Matthias G Friedrich, Balthasar Eberle, Dominik P Guensch
BACKGROUND: Hyperventilation with a subsequent breath-hold has been successfully used as a non-pharmacological vasoactive stimulus to induce changes in myocardial oxygenation. The purpose of this pilot study was to assess if this maneuver is feasible in patients with multi-vessel coronary artery disease (CAD), and if it is effective at detecting coronary artery stenosis > 50% determined by quantitative coronary angiography (QCA). METHODS: Twenty-six patients with coronary artery stenosis (QCA > 50% diameter stenosis) underwent a contrast-free cardiovascular magnetic resonance (CMR) exam in the time interval between their primary coronary angiography and a subsequent percutaneous coronary intervention (PCI, n = 24) or coronary artery bypass (CABG, n = 2) revascularization procedure...
May 7, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29701845/expansion-of-transcatheter-aortic-valve-implantation-new-indications-and-socio-economic-considerations
#6
Thomas Pilgrim, Stephan Windecker
No abstract text is available yet for this article.
April 26, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29699615/long-term-assessment-of-bioresorbable-coronary-scaffolds-disappearing-stents-reappearing-atherosclerosis
#7
EDITORIAL
Stephan Windecker, Raffaele Piccolo, Yasushi Ueki
No abstract text is available yet for this article.
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29691071/incidence-determinants-and-clinical-impact-of-definite-stent-thrombosis-on-mortality-in-women-from-the-win-des-collaborative-patient-level-pooled-analysis
#8
Laura S Kerkmeijer, Bimmer E Claessen, Usman Baber, Samantha Sartori, Jaya Chandrasekhar, Giulio G Stefanini, Gregg W Stone, P Gabriel Steg, Alaide Chieffo, Giora Weisz, Stephan Windecker, Ghada W Mikhail, Adnan Kastrati, Marie-Claude Morice, George D Dangas, Robbert J de Winter, Roxana Mehran
BACKGROUND: Predictors and clinical outcomes of stent thrombosis (ST) in women have not been well investigated. Present study aimed to identify predictors of definite ST and its impact on mortality in women undergoing percutaneous coronary intervention (PCI). METHODS: Patient-level data of women enrolled in 26 randomized trials of DES was pooled. The study population was stratified based on the presence or absence of definite ST. Cox proportional hazards models were used to determine the predictors of definite ST...
April 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29669787/rediscovering-the-orbit-of-pci-after-orbita
#9
Deepak L Bhatt, Bernard J Gersh, Ph Gabriel Steg, Robert A Harrington, Stephan Windecker
The publication of the Objective Randomised Blinded Investigation with Optimal Medical Therapy of Angioplasty in Stable Angina (ORBITA) trial generated an immense amount of discussion, debate, and controversy.1 The editorialists posed in their title whether the ORBITA trial is the "Last nail in the coffin for PCI in stable angina?"2 The ensuing press coverage has been extensive, though mostly one-sided and largely following the negative tone set by the editorial. The exchange on social media has been at times vitriolic, both pro and con - the number of Tweets of the article (1716 as of February 25, 2018) now exceeds the number of patients enrolled by over seven-fold...
April 18, 2018: Circulation
https://www.readbyqxmd.com/read/29649323/prognosis-of-cardiovascular-and-non-cardiovascular-multimorbidity-after-acute-coronary-syndrome
#10
Silvia Canivell, Olivier Muller, Baris Gencer, Dik Heg, Roland Klingenberg, Lorenz Räber, David Carballo, Christian Matter, Thomas Lüscher, Stephan Windecker, François Mach, Nicolas Rodondi, David Nanchen
OBJECTIVE: To examine the prognosis of patients with cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome compared to patients without prior multimorbidity. METHODS: This multicenter prospective cohort study in Switzerland included 5,635 patients hospitalized with acute coronary syndrome between 2009 and 2014, with a one-year follow-up period. We defined cardiovascular and non-cardiovascular multimorbidity as having at least two prior comorbidities before the index hospitalization...
2018: PloS One
https://www.readbyqxmd.com/read/29628287/questions-and-answers-on-diagnosis-and-management-of-patients-with-peripheral-arterial-diseases-a-companion-document-of-the-2017-esc-guidelines-for-the-diagnosis-and-treatment-of-peripheral-arterial-diseases-in-collaboration-with-the-european-society-for-vascular
#11
Authors/Task Force Members, Victor Aboyans, Martin Björck, Marianne Brodmann, Jean-Philippe Collet, Martin Czerny, Marco De Carlo, A Ross Naylor, Marco Roffi, Michal Tendera, Charalambos Vlachopoulos, Jean-Baptiste Ricco, Document Reviewers, Petr Widimsky, Philippe Kolh, Florian Dick, Melina Vega de Ceniga, Massimo Francesco Piepoli, Horst Sievert, Jakub Sulzenko, Esc Committee For Practice Guidelines Cpg, Stephan Windecker, Victor Aboyans, Stefan Agewall, Emanuele Barbato, Héctor Bueno, Antonio Coca, Jean-Philippe Collet, Ioan Mircea Coman, Veronica Dean, Victoria Delgado, Donna Fitzsimons, Oliver Gaemperli, Gerhard Hindricks, Bernard Iung, Peter Jüni, Hugo A Katus, Juhani Knuuti, Patrizio Lancellotti, Christophe Leclercq, Theresa McDonagh, Massimo Francesco Piepoli, Piotr Ponikowski, Dimitrios J Richter, Marco Roffi, Evgeny Shlyakhto, Iain A Simpson, Jose Luis Zamorano
No abstract text is available yet for this article.
April 5, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29579192/new-prospects-for-pcsk9-inhibition
#12
Ulf Landmesser, M John Chapman, Jane K Stock, Pierre Amarenco, Jill J F Belch, Jan Borén, Michel Farnier, Brian A Ference, Stephan Gielen, Ian Graham, Diederick E Grobbee, G Kees Hovingh, Thomas F Lüscher, Massimo F Piepoli, Kausik K Ray, Erik S Stroes, Olov Wiklund, Stephan Windecker, Jose Luis Zamorano, Fausto Pinto, Lale Tokgözoglu, Jeroen J Bax, Alberico L Catapano
No abstract text is available yet for this article.
March 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29566812/transcatheter-aortic-valve-replacement-in-patients-with-low-flow-low-gradient-aortic-stenosis-the-topas-tavi-registry
#13
Henrique Barbosa Ribeiro, Stamatios Lerakis, Martine Gilard, João L Cavalcante, Raj Makkar, Howard C Herrmann, Stephan Windecker, Maurice Enriquez-Sarano, Asim N Cheema, Luis Nombela-Franco, Ignacio Amat-Santos, Antonio J Muñoz-García, Bruno Garcia Del Blanco, Alan Zajarias, John C Lisko, Salim Hayek, Vasilis Babaliaros, Florent Le Ven, Thomas G Gleason, Tarun Chakravarty, Wilson Y Szeto, Marie-Annick Clavel, Alberto de Agustin, Vicenç Serra, John T Schindler, Abdellaziz Dahou, Rishi Puri, Emilie Pelletier-Beaumont, Melanie Côté, Philippe Pibarot, Josep Rodés-Cabau
BACKGROUND: Few data exist on patients with low-flow, low-gradient aortic stenosis (LFLG-AS) undergoing transcatheter aortic valve replacement (TAVR). Also, very scarce data exist on the usefulness of dobutamine stress echocardiography (DSE) before TAVR in these patients. OBJECTIVES: The authors sought to evaluate clinical outcomes and changes in left ventricular ejection fraction (LVEF) following TAVR in patients with classical LFLG-AS. METHODS: This multicenter registry included 287 patients with LFLG-AS undergoing TAVR...
March 27, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29553941/left-ventricular-afterload-reduction-by-transcatheter-aortic-valve-implantation-in-severe-aortic-stenosis-and-its-prompt-effects-on-comprehensive-coronary-hemodynamics
#14
Michael Stoller, Steffen Gloekler, Rainer Zbinden, David Tueller, Franz Eberli, Stephan Windecker, Peter Wenaweser, Christian Seiler
AIMS: Testing the hypothesis that left ventricular (LV) afterload reduction in severe aortic valve stenosis (AS) by transcatheter aortic valve implantation (TAVI) acutely improves coronary hemodynamics. METHODS AND RESULTS: This was a prospective, pathophysiologic study in 40 patients with severe AS undergoing TAVI. Endpoints were determined invasively immediately before and after TAVI without altering coronary stenotic lesions if present. Myocardial hyperemia was induced by intravenous adenosine...
March 20, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29544607/bivalirudin-or-heparin-in-patients-undergoing-invasive-management-of-acute-coronary-syndromes
#15
Giuseppe Gargiulo, Greta Carrara, Enrico Frigoli, Pascal Vranckx, Sergio Leonardi, Nestor Ciociano, Gianluca Campo, Ferdinando Varbella, Paolo Calabrò, Stefano Garducci, Alessandro Iannone, Carlo Briguori, Giuseppe Andò, Gabriele Crimi, Ugo Limbruno, Roberto Garbo, Paolo Sganzerla, Filippo Russo, Alessandro Lupi, Bernardo Cortese, Arturo Ausiello, Salvatore Ierna, Giovanni Esposito, Dennis Zavalloni, Andrea Santarelli, Gennaro Sardella, Simone Tresoldi, Nicoletta de Cesare, Alessandro Sciahbasi, Antonio Zingarelli, Paolo Tosi, Arnoud van 't Hof, Elmir Omerovic, Salvatore Brugaletta, Stephan Windecker, Marco Valgimigli
BACKGROUND: Contrasting evidence exists on the comparative efficacy and safety of bivalirudin and unfractionated heparin (UFH) in relation to the planned use of glycoprotein IIb/IIIa inhibitors (GPIs). OBJECTIVES: This study assessed the efficacy and safety of bivalirudin compared with UFH with or without GPIs in patients with acute coronary syndrome (ACS) who underwent invasive management. METHODS: In the MATRIX (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX) program, 7,213 patients were randomly assigned to receive either bivalirudin or UFH with or without GPIs at discretion of the operator...
March 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29540631/current-use-of-intracoronary-imaging-in-interventional-practice-results-of-a-european-association-of-percutaneous-cardiovascular-interventions-eapci-and-japanese-association-of-cardiovascular-interventions-and-therapeutics-cvit-clinical-practice-survey
#16
Konstantinos C Koskinas, Masato Nakamura, Lorenz Räber, Roisin Colleran, Kazushige Kadota, Davide Capodanno, William Wijns, Takashi Akasaka, Marco Valgimigli, Giulio Guagliumi, Stephan Windecker, Robert A Byrne
BACKGROUND: This study evaluated the views of the cardiology community on the clinical use of coronary intravascular imaging (IVI).Methods and Results:A web-based survey was distributed to 31,893 individuals, with 1,105 responses received (3.5% response rate); 1,010 of 1,097 respondents (92.1%) self-reported as interventional cardiologists, 754 (68.7%) with >10 years experience. Overall, 96.1% had personal experience with IVI (95.5% with intravascular ultrasound [IVUS], 69.8% with optical coherence tomography [OCT], and 7...
April 25, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29537966/current-use-of-intracoronary-imaging-in-interventional-practice-results-of-a-european-association-of-percutaneous-cardiovascular-interventions-eapci-and-japanese-association-of-cardiovascular-interventions-and-therapeutics-cvit-clinical-practice-survey
#17
Konstantinos C Koskinas, Masato Nakamura, Lorenz Räber, Roisin Colleran, Kazushige Kadota, Davide Capodanno, William Wijns, Takashi Akasaka, Marco Valgimigli, Giulio Guagliumi, Stephan Windecker, Robert A Byrne
AIMS: This study evaluated the views of the cardiology community on the clinical use of coronary intravascular imaging (IVI). METHODS AND RESULTS: A web-based survey was distributed to 31,893 individuals, with 1,105 responses received (3.5% response rate); 1,010 of 1,097 respondents (92.1%) self-reported as interventional cardiologists, 754 (68.7%) with >10 years experience. Overall, 96.1% had personal experience with IVI (95.5% with intravascular ultrasound [IVUS], 69...
March 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29506938/computed-tomography-detection-and-quantification-of-left-atrial-appendage-residual-patency-as-collateral-finding-after-percutaneous-closure
#18
Marco Angelillis, Giuseppe Gargiulo, Aris Moschovitis, Monika Fürholz, Samera Shakir, Nicolo Piazza, Lorenz Räber, Bernhard Meier, Steffen Gloekler, Stephan Windecker, Marco Valgimigli
No abstract text is available yet for this article.
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29501544/the-impact-of-left-ventricular-diastolic-dysfunction-on-clinical-outcomes-after-transcatheter-aortic-valve-replacement
#19
Masahiko Asami, Jonas Lanz, Stefan Stortecky, Lorenz Räber, Anna Franzone, Dik Heg, Lukas Hunziker, Eva Roost, George Cm Siontis, Marco Valgimigli, Stephan Windecker, Thomas Pilgrim
OBJECTIVES: This study sought to determine the impact of left ventricular diastolic dysfunction (LVDD) on clinical outcomes in patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: Left ventricular (LV) hypertrophy in response to afterload increase promotes the development of LVDD and represents an early stage in the progression to valvular heart failure. METHODS: In a consecutive cohort of 777 aortic stenosis patients undergoing TAVR, LVDD was categorized according to the latest guidelines...
March 26, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29493510/short-term-outcome-after-left-main-interventions-in-patients-presenting-with-acute-coronary-syndrome
#20
Slayman Obeid, Nooraldaem Yousif, Andreas Schelldorfer, Mohammady Shahin, Lorenz Räber, Baris Gencer, François Mach, Marco Roffi, Christian M Matter, Stephan Windecker, Thomas F Lüscher
OBJECTIVE: To assess the efficacy and safety of coronary left main (LM) disease interventions in patients with acute coronary syndromes (ACS) as compared to those without LM coronary artery disease. METHODS: A total of 2899 patients with ACS, enrolled in the prospective Swiss Program University Medicine ACS (SPUM-ACS) cohort, were included. The primary endpoints of independently adjudicated major adverse cardiovascular and cerebrovascular event (MACCE) and net adverse clinical event (NACE) were determined at 30-day follow-up...
March 2018: Journal of Invasive Cardiology
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