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Stephan Windecker

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https://www.readbyqxmd.com/read/28728657/frequency-timing-and-impact-of-access-site-and-non-access-site-bleeding%C3%A2-on-mortality-among-patients%C3%A2-undergoing-transcatheter-aortic%C3%A2-valve%C3%A2-replacement
#1
Raffaele Piccolo, Thomas Pilgrim, Anna Franzone, Marco Valgimigli, Alan Haynes, Masahiko Asami, Jonas Lanz, Lorenz Räber, Fabien Praz, Bettina Langhammer, Eva Roost, Stephan Windecker, Stefan Stortecky
OBJECTIVES: The aim of this study was to examine the frequency, timing, and association of access-site and non-access-site bleeding with mortality in the setting of transcatheter aortic valve replacement (TAVR) during long-term follow-up. BACKGROUND: Bleeding is frequent and associated with impaired prognosis in patients undergoing TAVR. It is currently unknown whether the site of bleeding differentially influences the outcomes of TAVR patients. METHODS: In total, 926 consecutive patients undergoing TAVR from 2007 through 2014 were evaluated...
July 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28698293/the-conundrum-of-permanent-pacemaker-implantation-after-transcatheter-aortic-valve-implantation
#2
EDITORIAL
Anna Franzone, Stephan Windecker
No abstract text is available yet for this article.
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28671552/mid-term-clinical-outcomes-with-everolimus-eluting-bioresorbable-scaffolds-versus-everolimus-eluting-metallic-stents-for-percutaneous-coronary-interventions-a-meta-analysis-of-randomized-trials
#3
Salvatore Cassese, Byrne A Robert, Peter Jüni, Joanna J Wykrzykowska, Serban Puricel, Gjin Ndrepepa, Heribert Schunkert, Massimiliano Fusaro, Stephane Cook, Takeshi Kimura, Jose P S Henriques, Patrick W Serruys, Stephan Windecker, Adnan Kastrati
AIMS: To compare the mid-term clinical outcomes of patients treated with everolimus-eluting bioresorbable scaffold (BVS) versus everolimus-eluting metallic stent (EES) for percutaneous coronary intervention. METHODS AND RESULTS: We performed a meta-analysis of aggregate data by searching Medline, EMBASE, Cochrane databases and proceedings of international meetings for randomized trials reporting the clinical outcomes beyond 1 year of patients treated with BVS versus EES...
July 4, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28662808/arterial-remodeling-after-bioresorbable-scaffolds-and-metallic-stents
#4
Patrick W Serruys, Yuki Katagiri, Yohei Sotomi, Yaping Zeng, Bernard Chevalier, René J van der Schaaf, Andreas Baumbach, Pieter Smits, Nicolas M van Mieghem, Antonio Bartorelli, Paul Barragan, Anthony Gershlick, Ran Kornowski, Carlos Macaya, John Ormiston, Jonathan Hill, Irene M Lang, Mohaned Egred, Jean Fajadet, Maciej Lesiak, Stephan Windecker, Robert A Byrne, Lorenz Räber, Robert-Jan van Geuns, Gary S Mintz, Yoshinobu Onuma
BACKGROUND: Although previous observational studies have documented late luminal enlargement and expansive remodeling following implantation of a bioresorbable vascular scaffold (BVS), no comparison with metallic stents has been conducted in a randomized fashion. OBJECTIVES: This study sought to compare vessel remodeling patterns after either Absorb BVS or Xience metallic drug-eluting stent (DES) implantation (Abbott Vascular, Santa Clara, California) and determine the independent predictors of remodeling...
July 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28658478/long-term-safety-and-efficacy-of-new-generation-drug-eluting-stents-in-women-with-acute-myocardial-infarction-from-the-women-in-innovation-and-drug-eluting-stents-win-des-collaboration
#5
Gennaro Giustino, Rafael Harari, Usman Baber, Samantha Sartori, Gregg W Stone, Martin B Leon, Stephan Windecker, Patrick W Serruys, Adnan Kastrati, Clemens Von Birgelen, Takeshi Kimura, Giulio G Stefanini, George D Dangas, William Wijns, P Gabriel Steg, Marie-Claude Morice, Edoardo Camenzind, Giora Weisz, Pieter C Smits, Sabato Sorrentino, Madhav Sharma, Serdar Farhan, Michela Faggioni, David Kandzari, Soren Galatius, Raban V Jeger, Marco Valgimigli, Dipti Itchhaporia, Laxmi Mehta, Hyo-Soo Kim, Alaide Chieffo, Roxana Mehran
Importance: Women with acute myocardial infarction (MI) undergoing mechanical reperfusion remain at increased risk of adverse cardiac events and mortality compared with their male counterparts. Whether the benefits of new-generation drug-eluting stents (DES) are preserved in women with acute MI remains unclear. Objective: To investigate the long-term safety and efficacy of new-generation DES vs early-generation DES in women with acute MI. Design, Setting, and Participants: Collaborative, international, individual patient-level data of women enrolled in 26 randomized clinical trials of DES were analyzed between July and December 2016...
June 28, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28625369/rationale-and-design-of-the-hunting-for-the-off-target-properties-of-ticagrelor-on-endothelial-function-and-other-circulating-biomarkers-in-humans-hi-tech-trial
#6
Sara Ariotti, Maarten van Leeuwen, Salvatore Brugaletta, Sergio Leonardi, Kristiaan Martijn Akkerhuis, Emrush Rexhaj, Gladys Janssens, Luis Ortega-Paz, Diego Rizzotti, Jan C van den Berge, Dierik Heg, Gloria Francolini, Stephan Windecker, Marco Valgimigli
BACKGROUND: Among the 3 approved oral P2Y12 inhibitors for the treatment for patients with acute coronary syndrome (ACS), ticagrelor, but not prasugrel or clopidogrel, has been associated with off-target properties, such as improved endothelial-dependent vasomotion and increased adenosine plasma levels. METHODS: The HI-TECH study (NCT02587260) is a multinational, randomized, open-label, crossover study with a Latin squares design, conducted at 5 European sites, in which patients free from recurrent ischemic or bleeding events ≥30 days after a qualifying ACS were allocated to sequentially receive a 30 ± 5-day treatment with prasugrel, clopidogrel, and ticagrelor in random order...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28606888/neointima-and-neoatherosclerotic-characteristics-in-bare-metal-and-first-and-second-generation-drug-eluting-stents-in-patients-admitted-with-cardiovascular-events-attributed-to-stent-failure-an-optical-coherence-tomography-study
#7
Rodrigue Stettler, Jouke Dijkstra, Lorenz Räber, Ryo Torii, Yao-Jun Zhang, Antonis Karanasos, Shengnan Liu, Tom Crake, Steve Hamshere, Hector M Garcia-Garcia, Erhan Tenekecioglu, Muhiddin Ozkor, Stephan Windecker, Patrick W Serruys, Evelyn Regar, Anthony Mathur, Christos V Bourantas
AIMS: To assess neoatherosclerotic plaque morphology in bare metal (BMS) and 1st and 2nd generation drug eluting stents (DES) in patients presenting with an event attributed to stent failure. METHODS AND RESULTS: Thirty five patients (11 implanted with BMS, 13 with a 1st generation and 11 with a 2nd generation DES) admitted with an event due to stent failure who had neoatherosclerotic lesions on optical coherence tomography were included in the analysis. The lumen and stent borders were detected and the lipid and calcific tissue were identified in the neointima and their burden was estimated...
June 13, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28606165/pitfalls-in-tamvi-experience-with-the-repositionable-lotus%C3%A2-valve-system
#8
Paul P Heinisch, Fabien Praz, Bernhard Winkler, Stephan Windecker, Christoph Huber, Thierry Carrel
BACKGROUND: Simultaneous transapical implantation of transcatheter heart valves in the native mitral and aortic position may be considered as an alternative to surgical valve replacement in high-risk patients presenting with combined valve disease. CASE PRESENTATION: A 59-year-old female with severe aortic stenosis, severe mitral stenosis with mild mitral insufficiency, persistent atrial fibrillation, severe chronic obstructive pulmonary disease and NYHA class of IV was evaluated by our interdisciplinary heart team...
June 12, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28605779/use-of-the-dual-antiplatelet-therapy-score-to-guide-treatment-duration-after-percutaneous-coronary-intervention
#9
RANDOMIZED CONTROLLED TRIAL
Raffaele Piccolo, Giuseppe Gargiulo, Anna Franzone, Andrea Santucci, Sara Ariotti, Andrea Baldo, Carlo Tumscitz, Aris Moschovitis, Stephan Windecker, Marco Valgimigli
Background: The dual-antiplatelet therapy (DAPT) score was developed to identify patients more likely to derive harm (score <2) or benefit (score ≥2) from prolonged DAPT after percutaneous coronary intervention (PCI). Objective: To evaluate the safety and efficacy of DAPT duration according to DAPT score. Design: Retrospective assessment of DAPT score-guided treatment duration in a randomized clinical trial. (ClinicalTrials.gov: NCT00611286)...
July 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28570259/propensity-score-matched-comparison-of-the-cera-pfo-occluder-with-the-amplatzer-pfo-occluder-for-percutaneous-closure-of-patent-foramen-ovale-without-echocardiographic-guidance
#10
Mirjam Ulmi, Fabien Praz, George C M Siontis, Andreas Wahl, Stephan Windecker, Heinrich P Mattle, Bernhard Meier
BACKGROUND: Percutaneous patent foramen ovale (PFO) closure has become a routine procedure and was proven to be safe and feasible. In a recently published pooled analysis of randomized trials, percutaneous PFO closure was shown to more effectively reduce recurrent stroke when compared with medical therapy in patients with cryptogenic strokes. However, procedural safety and closure rate are device dependent. METHODS: We performed a propensity-score matched comparison of 28 patients undergoing percutaneous PFO closure using the Cera PFO occluder (CPO) with 28 patients who received the Amplatzer PFO occluder (APO)...
May 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28536005/effects-of-coronary-artery-disease-in-patients-undergoing-transcatheter-aortic-valve-implantation-a-study-of-age-and-gender-matched-cohorts
#11
Anna Franzone, Stefan Stortecky, Lorenz Räber, Dik Heg, Kyohei Yamaji, Raffaele Piccolo, Masahiko Asami, Jonas Lanz, Fabien Praz, Kostantinos Koskinas, Thomas Zanchin, Peter Wenaweser, Marco Valgimigli, Peter Jüni, Thomas Pilgrim, Stephan Windecker
BACKGROUND: The prognostic role of concomitant coronary artery disease (CAD) among patients undergoing transcatheter aortic valve implantation (TAVI) is still uncertain. METHODS: Data from the Bern TAVI Registry and the Bern PCI Registry were analyzed. Patients with concomitant CAD undergoing TAVI (TAVI+CAD) were age- and gender-matched to the following two cohorts: patients without CAD undergoing TAVI (TAVI-noCAD) and patients with stable CAD undergoing percutaneous coronary intervention (CAD-noAS)...
May 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28528767/acute-kidney-injury-after-radial-or-femoral-access-for-invasive-acute-coronary-syndrome-management-aki-matrix
#12
Giuseppe Andò, Bernardo Cortese, Filippo Russo, Martina Rothenbühler, Enrico Frigoli, Giuseppe Gargiulo, Carlo Briguori, Pascal Vranckx, Sergio Leonardi, Vincenzo Guiducci, Flavia Belloni, Fabio Ferrari, Jose Maria de la Torre Hernandez, Salvatore Curello, Francesco Liistro, Andrea Perkan, Stefano De Servi, Gavino Casu, Antonio Dellavalle, Dionigi Fischetti, Antonio Micari, Bruno Loi, Fabio Mangiacapra, Nunzio Russo, Fabio Tarantino, Francesco Saia, Dik Heg, Stephan Windecker, Peter Jüni, Marco Valgimigli
BACKGROUND: It remains unclear whether radial access (RA), compared with femoral access (FA), mitigates the risk of acute kidney injury (AKI). OBJECTIVES: The authors assessed the incidence of AKI in patients with acute coronary syndrome (ACS) enrolled in the MATRIX-Access (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial. METHODS: Among 8,404 patients, 194 (2.3%) were excluded due to missing creatinine values, no or an incomplete coronary angiogram, or previous dialysis...
May 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28526547/no-significant-gender-difference-in-hospitalizations-for-acute-coronary-syndrome-in-switzerland-over-the-time-period-of-2001-to-2010
#13
Hugo Saner, Jannette D Mollet, Claudia Berlin, Stephan Windecker, Bernhard Meier, Lorenz Räber, Marcel Zwahlen, Petra Stute
BACKGROUND: Morbidity and mortality from cardiovascular diseases have decreased since the 1970s in most Western societies. However, it is unclear if this positive trend can also be found in younger women suffering from acute coronary syndrome (ACS). METHODS: This is a prospective single center registry study including 11.015 women and men hospitalized for a first ACS between the years 2001 and 2010. We analyzed ACS rates according to sex and age group using Poisson regression in order to assess temporal trends...
May 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28504222/current-trends-in-structural-heart-interventions-an-overview-of-the-eapci-registries
#14
Dariusz Dudek, Emanuele Barbato, Andreas Baumbach, Stephan Windecker, Michael Haude
No abstract text is available yet for this article.
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28504221/current-trends-in-coronary-interventions-an-overview-from-the-eapci-registries
#15
Emanuele Barbato, Dariusz Dudek, Andreas Baumbach, Stephan Windecker, Michael Haude
No abstract text is available yet for this article.
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28504220/eapci-registries-a-first-step-towards-systematic-monitoring-of-european-interventional-cardiology-practice
#16
Emanuele Barbato, Dariusz Dudek, Andreas Baumbach, Stephan Windecker, Michael Haude
No abstract text is available yet for this article.
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28498562/effect-of-valve-design-and-anticoagulation-strategy-on-30-day-clinical-outcomes-in-transcatheter-aortic-valve-replacement-results-from-the-bravo-3-randomized-trial
#17
Axel Linke, Jaya Chandrasekhar, Samantha Sartori, Thierry Lefevre, Eric van Belle, Ulrich Schaefer, Didier Tchetche, Gennaro Sardella, John Webb, Antonio Colombo, Stephan Windecker, Birgit Vogel, Serdar Farhan, Sabato Sorrentino, Madhav Sharma, Clayton Snyder, Anita Asgar, Nicolas Dumonteil, Corrado Tamburino, Ulrich Hink, Roberto Violini, Pieter Stella, Debra Bernstein, Efthymios Deliargyris, Christian Hengstenberg, Usman Baber, Roxana Mehran, Prodromos Anthopoulos, George Dangas
BACKGROUND: Selection of valve and procedural anticoagulant type may impact bleeding and vascular complications in transfemoral transcatheter aortic valve replacement (TAVR). We sought to compare outcomes by valve [balloon expandable (BE) or non-BE] and anticoagulant [bivalirudin vs. unfractionated heparin (UFH)] type from the BRAVO-3 trial. METHODS: BRAVO-3 was a randomized multicenter trial included 500 BE-TAVR and 282 non-BE TAVR patients, randomized to bivalirudin vs...
May 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28475773/proceedings-from-the-2nd-european-clinical-consensus-conference-for-device-based-therapies-for-hypertension-state-of-the-art-and-considerations-for-the-future
#18
Felix Mahfoud, Roland E Schmieder, Michel Azizi, Atul Pathak, Horst Sievert, Costas Tsioufis, Thomas Zeller, Stefan Bertog, Peter J Blankestijn, Michael Böhm, Michel Burnier, Gilles Chatellier, Isabelle Durand Zaleski, Sebastian Ewen, Guido Grassi, Michael Joner, Sverre E Kjeldsen, Melvin D Lobo, Chaim Lotan, Thomas Felix Lüscher, Gianfranco Parati, Patrick Rossignol, Luis Ruilope, Faisal Sharif, Evert van Leeuwen, Massimo Volpe, Stephan Windecker, Adam Witkowski, William Wijns
No abstract text is available yet for this article.
May 5, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28472484/adverse-events-while-awaiting-myocardial-revascularization-a-systematic-review-and-meta-analysis
#19
Stuart J Head, Bruno R da Costa, Berend Beumer, Giulio G Stefanini, Fernando Alfonso, Peter M Clemmensen, Jean-Philippe Collet, Jochen Cremer, Volkmar Falk, Gerasimos Filippatos, Christian Hamm, A Pieter Kappetein, Adnan Kastrati, Juhani Knuuti, Philippe Kolh, Ulf Landmesser, Günther Laufer, Franz-Josef Neumann, Dimitrios J Richter, Patrick Schauerte, David P Taggart, Lucia Torracca, Marco Valgimigli, William Wijns, Adam Witkowski, Stephan Windecker, Peter Jüni, Miguel Sousa-Uva
OBJECTIVES: The aim of the current study was to estimate adverse event rates while awaiting myocardial revascularization and review criteria for prioritizing patients. METHODS: A PubMed search was performed on 19 January 2015, to identify English-language, original, observational studies reporting adverse events while awaiting coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Rates of death, non-fatal myocardial infarction (MI) and emergency revascularization were calculated as occurrence rates per 1000 patient-weeks and pooled using random-effects models...
May 2, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28437244/second-transcatheter-closure-for-residual-shunt-following-percutaneous-closure-of-patent-foramen-ovale
#20
Njomeza Susuri, Slayman Obeid, Mirjam Ulmi, George Cm Siontis, Andreas Wahl, Stephan Windecker, Fabian Nietlispach, Bernhard Meier, Fabien Praz
AIMS: Residual shunt following percutaneous patent foramen ovale (PFO) closure has been described in up to 49% of the patients and is associated with recurrent cerebrovascular events. Our aim was to evaluate the safety, feasibility, and mid-term outcomes of transcatheter residual shunt closure. METHODS AND RESULTS: From 1994 to July 2016, 2679 patients underwent transcatheter PFO closure for treatment of presumed paradoxical embolism at our institution. Among them, 100 patients (3...
April 25, 2017: EuroIntervention
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