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Stephan Windecker

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https://www.readbyqxmd.com/read/28198091/impact-of-chronic-kidney-disease-on-2-year-clinical-outcomes-in-patients-treated-with-6-month-or-24-month-dapt-duration-an-analysis-from-the-prodigy-trial
#1
Giuseppe Gargiulo, Andrea Santucci, Raffaele Piccolo, Anna Franzone, Sara Ariotti, Andrea Baldo, Giovanni Esposito, Aris Moschovitis, Stephan Windecker, Marco Valgimigli
OBJECTIVES: To assess whether moderate-to-severe CKD is a treatment modifier for benefit or harm in patients randomly allocated to 24-month versus 6-month DAPT. BACKGROUND: It is still unclear whether chronic kidney disease CKD should impact on the decision-making on optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). METHODS AND RESULTS: PRODIGY trial randomized 1970 all-comer patients at 24-month versus 6-month DAPT after PCI...
February 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28186289/surgical-antegrade-transcatheter-mitral-valve-implantation-for-symptomatic-mitral-valve-disease-and-heavily-calcified-annulus
#2
Bettina Langhammer, Christoph Huber, Stephan Windecker, Thierry Carrel
No abstract text is available yet for this article.
February 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28119252/what-determines-long-term-outcomes-using-fully-bioresorbable-scaffolds-the-device-the-operator-or-the-lesion
#3
Kyohei Yamaji, Lorenz Räber, Stephan Windecker
No abstract text is available yet for this article.
January 26, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28117283/prognostic-impact-of-invasive-hemodynamic-measurements-in-combination-with-clinical-and-echocardiographic-characteristics-on-2-year-clinical-outcomes-of-patients-undergoing-transcatheter-aortic-valve-implantation
#4
Anna Franzone, Crochan J O'Sullivan, Stefan Stortecky, Dik Heg, Jonas Lanz, René Vollenbroich, Fabien Praz, Raffaele Piccolo, Masahiko Asami, Eva Roost, Lorenz Räber, Marco Valgimigli, Stephan Windecker, Thomas Pilgrim
AIMS: To evaluate the prognostic utility of right heart catheterization (RHC)-derived measures among patients undergoing transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: Data of 469 patients included in the Bern TAVI Registry between August 2007 and December 2012 and undergoing pre-operative RHC were analyzed. The relationship between hemodynamic parameters and survival was evaluated with Cox proportional hazard models. At 2-year follow-up, 118 patients had died (25...
January 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28113248/prediction-of-atherosclerotic-plaque-development-in-an-in-vivo-coronary-arterial-segment-based-on-a-multi-level-modeling-approach
#5
Antonis Sakellarios, Lorenz Raber, Christos Bourantas, Themis Exarchos, Lambros Athanasiou, Gualtiero Pelosi, Oberdan Parodi, Konstantinos Koskinas, Katerina Naka, Lampros Michalis, Patrick Wjc Serruys, Hector Garcia-Garcia, Stephan Windecker, Dimitrios Fotiadis
OBJECTIVE: The aim of this study is to explore major mechanisms of atherosclerotic plaque growth, presenting a proof-of-concept numerical model. METHODS: To this aim, a human reconstructed left circumflex coronary artery is utilized for a multi-level modeling approach. More specifically, the first level consists of the modeling of blood flow and endothelial shear stress (ESS) computation. The second level includes the modeling of low and high density lipoprotein (LDL, HDL) and monocytes transport through the endothelial membrane to vessel wall...
October 19, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28109966/misconceptions-and-facts-about-aortic-stenosis
#6
REVIEW
Edgar Argulian, Stephan Windecker, Franz H Messerli
Aortic stenosis is the most common valvular heart disease leading to intervention and it is typically a disease of the elderly. Recent clinical advances have expanded the role of transcatheter aortic valve intervention in patients with severe aortic stenosis making aortic valve intervention feasible and effective even in patients at intermediate, high and prohibitive surgical risk. With the rapid advances in treatment proper diagnosis becomes crucial for a wide range of patients with aortic stenosis: from 'concordant' high-gradient aortic stenosis to 'discordant' low-gradient aortic stenosis...
January 18, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28104208/first-in-human-evaluation-of-a-novel%C3%A2-polymer-free-drug-filled-stent-angiographic-ivus-oct-and-clinical-outcomes-from%C3%A2-the%C3%A2-revelution-study
#7
Stephen G Worthley, Alexandre Abizaid, Ajay J Kirtane, Daniel I Simon, Stephan Windecker, Sandeep Brar, Ian T Meredith, Sharad Shetty, Ajay Sinhal, Alexandra Popma Almonacid, Daniel Chamié, Akiko Maehara, Gregg W Stone
OBJECTIVES: This study sought to assess the safety and effectiveness of the drug-filled stent (DFS) (Medtronic, Santa Rosa, California) in the treatment of patients with coronary artery disease. BACKGROUND: Polymer-free drug-eluting stents have the potential to improve clinical outcomes and facilitate shorter durations of dual antiplatelet therapy. The polymer-free DFS is made from a trilayered continuous wire with an outer cobalt chromium layer, a middle tantalum layer, and an inner lumen coated with sirolimus...
January 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28079554/latest-evidence-on-transcatheter-aortic-valve-implantation-vs-surgical-aortic-valve-replacement-for-the-treatment-of-aortic-stenosis-in-high-and-intermediate-risk-patients
#8
Fabien Praz, George C M Siontis, Subodh Verma, Stephan Windecker, Peter Jüni
PURPOSE OF REVIEW: The goal of this review is to summarize the current evidence supporting the use of transcatheter aortic valve implantation (TAVI) in high and intermediate-risk patients. The focus is on the five randomized controlled trials comparing TAVI with surgical aortic valve replacement (SAVR) published to date, as well as two recent meta-analyses. RECENT FINDINGS: TAVI has profoundly transformed the treatment of elderly patients presenting with symptomatic severe aortic stenosis...
March 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28077467/gut-microbiota-dependent-trimethylamine-n-oxide-in-acute-coronary-syndromes-a-prognostic-marker-for-incident-cardiovascular-events-beyond-traditional-risk-factors
#9
Xinmin S Li, Slayman Obeid, Roland Klingenberg, Baris Gencer, François Mach, Lorenz Räber, Stephan Windecker, Nicolas Rodondi, David Nanchen, Olivier Muller, Melroy X Miranda, Christian M Matter, Yuping Wu, Lin Li, Zeneng Wang, Hassan S Alamri, Valentin Gogonea, Yoon-Mi Chung, W H Wilson Tang, Stanley L Hazen, Thomas F Lüscher
AIMS: Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism of dietary trimethylamine (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary and secondary prevention subjects. However, the prognostic value of TMAO in the setting of acute coronary syndromes (ACS) remains unknown. METHODS AND RESULTS: We investigated the relationship of TMAO levels with incident cardiovascular risks among sequential patients presenting with ACS in two independent cohorts...
January 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28067197/comparison-of-procedural-and-clinical-outcomes-with-evolut-r-versus-medtronic-corevalve-a-swiss-tavi-registry-analysis
#10
Stephane Noble, Stefan Stortecky, Dik Heg, David Tuller, Raban Jeger, Stefan Toggweiler, Enrico Ferrari, Fabian Nietlispach, Maurizio Taramasso, Francesco Maisano, Jürg Grünenfelder, Peter Jüni, Christoph Huber, Thierry Carrel, Stephan Windecker, Peter Wenaweser, Marco Roffi
AIMS: Data on procedural and clinical outcomes after transcatheter aortic valve implantation (TAVI) with the new generation self-expanding Medtronic Evolut-R prosthesis in comparison with its predecessor, the Medtronic CoreValve, are scarce. METHODS AND RESULTS: In a nationwide, prospective, multi-center cohort study outcomes of consecutive transfemoral TAVI patients treated with the new- generation Medtronic Evolut-R (September 2014 - February 2016) and the Medtronic CoreValve (February 2011 - February 2016) were investigated...
January 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28062497/increased-proangiogenic-activity-of-mobilized-cd34-progenitor-cells-of-patients-with-acute-st-segment-elevation-myocardial-infarction-role-of-differential-micro-rna-378-expression
#11
Christian Templin, Julia Volkmann, Maximilian Y Emmert, Pavani Mocharla, Maja Müller, Nicolle Kraenkel, Jelena R Ghadri, Martin Meyer, Beata Styp-Rekowska, Sylvie Briand, Roland Klingenberg, Milosz Jaguszewski, Christian M Matter, Valentin Djonov, Francois Mach, Stephan Windecker, Simon P Hoerstrup, Thomas Thum, Thomas F Lüscher, Ulf Landmesser
OBJECTIVE: Proangiogenic effects of mobilized bone marrow-derived stem/progenitor cells are essential for cardiac repair after myocardial infarction. Micro-RNAs (miRNA/miR) are key regulators of angiogenesis. We investigated the differential regulation of angio-miRs, that is, miRNAs regulating neovascularization, in mobilized CD34(+) progenitor cells obtained from patients with an acute ST-segment-elevation myocardial infarction (STEMI) as compared with those with stable coronary artery disease or healthy subjects...
December 29, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28044986/ischemic-and-bleeding-outcomes-in-elderly-patients-undergoing-a-prolonged-versus-shortened-duration-of-dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-insights-from-the-prodigy-randomized-trial
#12
Raffaele Piccolo, Giulia Magnani, Sara Ariotti, Giuseppe Gargiulo, Marcello Marino, Andrea Santucci, Anna Franzone, Matteo Tebaldi, Dik Heg, Stephan Windecker, Marco Valgimigli
AIMS: To evaluate the efficacy and safety of 24-month vs. 6-month dual antiplatelet therapy (DAPT) among elderly (≥75 years) and non-elderly patients (<75 years) undergoing percutaneous coronary intervention. METHODS AND RESULTS: The primary efficacy endpoint of the PRODIGY trial was the composite of death, myocardial infarction, or cerebrovascular accident at 24-month follow-up. The key safety endpoint was type 2, 3 or 5 bleeding according to the BARC criteria...
January 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28029055/improved-risk-stratification-of-patients-with-acute-coronary-syndromes-using-a-combination-of-hstnt-nt-probnp-and-hscrp-with-the-grace-score
#13
Roland Klingenberg, Soheila Aghlmandi, Lorenz Räber, Baris Gencer, David Nanchen, Dik Heg, Sebastian Carballo, Nicolas Rodondi, François Mach, Stephan Windecker, Peter Jüni, Arnold von Eckardstein, Christian M Matter, Thomas F Lüscher
BACKGROUND: Clinical scores and biomarkers improve risk stratification of patients with acute coronary syndromes. However, little is known about their value in patients referred for coronary angiography. METHODS: Consecutive patients admitted at four Swiss university hospitals with a diagnosis of acute coronary syndrome were enrolled into the SPUM-ACS Biomarker Cohort between 2009 and 2012. Patients were followed at 30 days and 1 year with assessment of adjudicated events including all-cause mortality and the composite of all-cause mortality or non-fatal recurrent myocardial infarction...
December 1, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28026742/transcatheter-aortic-valve-replacement-for-the-treatment-of-pure-native-aortic%C3%A2-valve-regurgitation-a-systematic-review
#14
Anna Franzone, Raffaele Piccolo, George C M Siontis, Jonas Lanz, Stefan Stortecky, Fabien Praz, Eva Roost, René Vollenbroich, Stephan Windecker, Thomas Pilgrim
OBJECTIVES: This study sought to summarize available evidence on transcatheter aortic valve replacement (TAVR) for the treatment of native pure aortic regurgitation (AR). BACKGROUND: Surgical aortic valve replacement (SAVR) is the gold standard for the treatment of AR. However, case series of high-risk patients undergoing TAVR for native pure AR were reported. METHODS: We systematically searched Medline, Embase, and Scopus for reports of at least 5 patients with native pure AR undergoing TAVR...
November 28, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28011706/profiling-and-validation-of-circulating-micrornas-for-cardiovascular-events-in-patients-presenting-with-st-segment-elevation-myocardial-infarction
#15
Philipp Jakob, Tim Kacprowski, Sylvie Briand-Schumacher, Dik Heg, Roland Klingenberg, Barbara E Stähli, Milosz Jaguszewski, Nicolas Rodondi, David Nanchen, Lorenz Räber, Pierre Vogt, Francois Mach, Stephan Windecker, Uwe Völker, Christian M Matter, Thomas F Lüscher, Ulf Landmesser
AIMS: MicroRNAs (miRNA) are important non-coding modulators controlling patterns of gene expression. However, profiling and validation of circulating miRNA levels related to adverse cardiovascular outcome has not been performed in patients with an acute coronary syndrome (ACS). METHODS AND RESULTS: In a multicentre, prospective ACS cohort, 1002 out of 2168 patients presented with ST-segment elevation myocardial infarction (STEMI). Sixty-three STEMI patients experienced an adjudicated major cardiovascular event (MACE, defined as cardiac death or recurrent myocardial infarction) within 1 year of follow-up...
December 23, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27998831/selective-use-of-contemporary-drug-eluting-stents-in-primary-angioplasty-for-st-elevation-myocardial-infarction-pooled-analysis-of-comfortable-ami-and-examination
#16
Andreas Baumbach, Dik Heg, Lorenz Räber, Miodrag Ostoijc, Salvatore Brugaletta, Julian W Strange, Thomas W Johnson, Peter Juni, Thomas Engstrøm, Patrick W Serruys, Manel Sabate, Stephan Windecker
AIMS: Selective use of DES only in patients at higher risk of MACE is common practice, particularly in healthcare systems with a large premium payable for DES. We aimed to identify subgroups of patients in which the use of BMS in primary percutaneous coronary intervention (PPCI) for STEMI can still be justified. METHODS AND RESULTS: We performed a patient-level pooled analysis of COMFORTABLE AMI and EXAMINATION comparing contemporary DES with BMS in PPCI. A risk score was applied using three parameters: lesion length >15 mm, vessel size <3 mm, and diabetes mellitus...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/27993758/first-in-man-6-month-results-of-qvanteq-surface-modified-coronary-stent-system-in-native-coronary-stenosis
#17
Pannipa Suwannasom, Yohei Sotomi, Roberto Corti, David J Kurz, Marco Roffi, Clemens von Birgelen, Stefano Buzzi, Arik Zucker, Jouke Dijkstra, Joanna J Wykrzykowska, Robbert J de Winter, Stephan Windecker, Yoshinobu Onuma, Patrick W Serruys, Joost Daemen, Lorenz Räber
AIMS: In pre-clinical studies, a bare metal cobalt-chromium stent with an active surface oxide layer modification (BMSmod) has shown to effectively inhibited neointimal hyperplasia. We sought to assess both clinical safety and feasibility of the BMSmod. METHODS AND RESULTS: In this prospective, nonrandomized, first-in-man multicenter study, a total of 31 patients with de novo coronary lesions, reference lumen diameters of 2.5 - 3.5 mm and lesion length ≤16 mm were enrolled...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27970233/tct-84-outcomes-of-transcatheter-aortic-valve-replacement-without-predilation-of-the-aortic-valve-insights-from-1942-patients-included-in-the-source-3-registry
#18
Nicolas Dumonteil, Thomas Walther, Frederic Pinaud, Christian Terkelsen, Christian Frerker, Frederic Collart, Jochen Wöhrle, Stephan Windecker, Christian Butter, Leo Ihlberg
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970054/tct-678-incidence-predictors-and-clinical-outcomes-of-coronary-obstruction-following-transcatheter-aortic-valve-implantation-for-degenerative-bioprosthetic-surgical-valves-insights-from-the-vivid-registry
#19
Henrique Ribeiro, Josep Rodés-Cabau, Jong Kwan Park, Philipp Blanke, Jonathon Leipsic, Vinayak Bapat, Raj Makkar, Matheus Simonato Dos Santos, Marco Barbanti, Joachim Schofer, Sabine Bleiziffer, Azeem Latib, David Hildick-Smith, Patrizia Presbitero, Stephan Windecker, Massimo Napodano, Alfredo Cerillo, Mohamed Abdel-Wahab, Didier Tchetche, Claudia Fiorina, Mauricio Cohen, Mayra Guerrero, Brian Whisenant, Fabian Nietlispach, Luis Nombela Franco, Fabio Brito, Pedro Lemos, John Webb, Danny Dvir
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969861/tct-49-two-year-clinical-outcome-of-everolimus-eluting-bioresorbable-scaffold-vs-%C3%A2-durable-polymer-everolimus-eluting-metallic-stent-in-patients-with-st-segment-elevation-myocardial-infarction-results-of-the-randomized-absorb-st-segment-elevation-myocardial
#20
Stephan Windecker, Taku Asano, Lorenz Raber, Salvatore Brugaletta, Manel Sabate, Yoshinobu Onuma, Patrick Serruys
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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