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Stephan Windecker

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https://www.readbyqxmd.com/read/28801383/long-term-outcomes-after-acute-myocardial-infarction-in-countries-with-different-socioeconomic-environments-an-international-prospective-cohort-study
#1
Judith Kämpfer, Andriy Yagensky, Tomasz Zdrojewski, Stephan Windecker, Bernhard Meier, Mykhailo Pavelko, Iryna Sichkaruk, Piotr Kasprzyk, Marzin Gruchala, Mikael Giacomini, Lukas Räber, Hugo Saner
BACKGROUND: Hospital-based data on the impact of socioeconomic environment on long-term survival after myocardial infarction (MI) are lacking. We compared outcome and quality of secondary prevention in patients after MI living in three different socioeconomic environments including patients from three tertiary-care teaching hospitals with similar service population size in Switzerland, Poland and Ukraine. METHODS: This is a prospective cohort study of patients with a first MI in three different tertiary-care teaching hospitals in Bern (Switzerland), Gdansk (Poland) and Lutsk (Ukraine) during the acute phase in the year 2010 and follow-up of these patients with a questionnaire and, if necessary, telephone interviews 3...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28797353/clinical-outcomes-with-a-repositionable-self-expanding-transcatheter-aortic%C3%A2-valve%C3%A2-prosthesis-the-international-forward-study
#2
Eberhard Grube, Nicolas M Van Mieghem, Sabine Bleiziffer, Thomas Modine, Johan Bosmans, Ganesh Manoharan, Axel Linke, Werner Scholtz, Didier Tchétché, Ariel Finkelstein, Ramiro Trillo, Claudia Fiorina, Antony Walton, Christopher J Malkin, Jae K Oh, Hongyan Qiao, Stephan Windecker
BACKGROUND: Clinical outcomes in large patient populations from real-world clinical practice with a next-generation self-expanding transcatheter aortic valve are lacking. OBJECTIVES: This study sought to document the clinical and device performance outcomes of transcatheter aortic valve replacement (TAVR) with a next-generation, self-expanding transcatheter heart valve (THV) system in patients with severe symptomatic aortic stenosis (AS) in routine clinical practice...
August 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28796809/a-randomized-multicenter-trial-comparing-the-xience-everolimus-eluting-stent-with-the-cypher-sirolimus-eluting-stent-in-the-treatment-of-female-patients-with-de-novo-coronary-artery-lesions-the-spirit-women-study
#3
Anna Franzone, Serge Zaugg, Raffaele Piccolo, Maria Grazia Modena, Ghada W Mikhail, Josepa Mauri Ferré, Ruth Strasser, Liliana Grinfeld, Dik Heg, Peter Jüni, Stephan Windecker, Marie-Claude Morice
BACKGROUND: The comparative performance of different drug-eluting stents (DES) among female patients has not been assessed in a randomized manner. OBJECTIVES: The SPIRIT Women Clinical Evaluation trial compared the durable polymer everolimus-eluting XIENCE stent (DP-EES) with the durable polymer sirolimus-eluting Cypher stent (DP-SES) in women undergoing percutaneous coronary intervention (PCI). METHODS: A total of 455 female patients with stable CAD were randomly assigned to receive DP-EES (n = 304) or DP-SES (n = 151)...
2017: PloS One
https://www.readbyqxmd.com/read/28780509/rehospitalizations-following-primary-percutaneous-coronary-intervention-in-patients-with-st-elevation-myocardial-infarction-results-from-a-multi-center-randomized-trial
#4
Ernest Spitzer, Martina Frei, Serge Zaugg, Susanne Hadorn, Henning Kelbaek, Miodrag Ostojic, Andreas Baumbach, David Tüller, Marco Roffi, Thomas Engstrom, Giovanni Pedrazzini, Vladan Vukcevic, Michael Magro, Ran Kornowski, Thomas F Lüscher, Clemens von Birgelen, Dik Heg, Stephan Windecker, Lorenz Räber
BACKGROUND: Rehospitalizations (RHs) after ST-elevation myocardial infarction carry a high economic burden and may deteriorate quality of life. Characterizing patients at higher risk may allow the design of preventive measures. We studied the frequency, reasons, and predictors for unplanned cardiac and noncardiac RHs in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. METHODS AND RESULTS: In this post-hoc analysis of the COMFORTABLE AMI (Comparison of Biolimus Eluted From an Erodible Stent Coating With Bare Metal Stents in Acute ST-Elevation Myocardial Infarction; NCT00962416) trial including 1137 patients, unplanned cardiac and noncardiac RHs occurred in 133 (11...
August 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28780036/transcatheter-tricuspid-valve-repair-with%C3%A2-a-new-transcatheter-coaptation-system-for-the-treatment-of-severe-tricuspid-regurgitation-1-year-clinical-and-echocardiographic-results
#5
Gidon Perlman, Fabien Praz, Rishi Puri, Hadass Ofek, Jian Ye, Francois Philippon, Thierry Carrel, Philippe Pibarot, Adrian Attinger, Nay Min Htun, Danny Dvir, Robert Moss, Francisco Campelo-Parada, Elisabeth Bédard, David Reineke, Aris Moschovitis, Sandra Lauck, Philipp Blanke, Jonathon Leipsic, Stephan Windecker, Josep Rodés-Cabau, John Webb
OBJECTIVES: This study sought to describe the 1-year experience with the transcatheter FORMA system for severe tricuspid regurgitation (TR). BACKGROUND: Severe TR is associated with significant morbidity and mortality. Novel transcatheter therapies have been recently developed. METHODS: Eighteen patients underwent device implantation at 3 centers in Canada and Switzerland. Baseline characteristics, procedural, 30-day, and 1-year outcomes were prospectively evaluated using multimodality imaging and hemodynamic and clinical assessments...
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28734923/diagnostic-accuracy-of-coronary-ct-angiography-for%C3%A2-the-evaluation-of-bioresorbable-vascular-scaffolds
#6
Carlos Collet, Bernard Chevalier, Angel Cequier, Jean Fajadet, Marcello Dominici, Steffen Helqvist, A J Van Boven, Dariusz Dudek, Dougal McClean, Manuel Almeida, Jan J Piek, Erhan Tenekecioglu, Antonio Bartorelli, Stephan Windecker, Patrick W Serruys, Yoshinobu Onuma
OBJECTIVES: To assess the diagnostic accuracy of coronary computed tomography angiography (CTA) for bioresorbable vascular scaffold (BVS) evaluation. BACKGROUND: Coronary CTA has emerged as a noninvasive method to evaluate patients with suspected or established coronary artery disease. The diagnostic accuracy of coronary CTA to evaluate angiographic outcomes after BVS implantation has not been well established. METHODS: In the ABSORB II (A Bioresorbable Everolimus-Eluting Scaffold Versus a Metallic Everolimus-Eluting Stent II) study, patients were randomized either to receive treatment with the BVS or everolimus-eluting metallic stent...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28732814/bioresorbable-scaffolds-in-search-of-event-free-dissolution
#7
Raffaele Piccolo, Peter Jüni, Stephan Windecker
No abstract text is available yet for this article.
July 18, 2017: Lancet
https://www.readbyqxmd.com/read/28728657/frequency-timing-and-impact-of-access-site-and-non-access-site-bleeding%C3%A2-on-mortality-among-patients%C3%A2-undergoing-transcatheter-aortic%C3%A2-valve%C3%A2-replacement
#8
Raffaele Piccolo, Thomas Pilgrim, Anna Franzone, Marco Valgimigli, Alan Haynes, Masahiko Asami, Jonas Lanz, Lorenz Räber, Fabien Praz, Bettina Langhammer, Eva Roost, Stephan Windecker, Stefan Stortecky
OBJECTIVES: The aim of this study was to examine the frequency, timing, and association of access-site and non-access-site bleeding with mortality in the setting of transcatheter aortic valve replacement (TAVR) during long-term follow-up. BACKGROUND: Bleeding is frequent and associated with impaired prognosis in patients undergoing TAVR. It is currently unknown whether the site of bleeding differentially influences the outcomes of TAVR patients. METHODS: In total, 926 consecutive patients undergoing TAVR from 2007 through 2014 were evaluated...
July 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28698293/the-conundrum-of-permanent-pacemaker-implantation-after-transcatheter-aortic-valve-implantation
#9
EDITORIAL
Anna Franzone, Stephan Windecker
No abstract text is available yet for this article.
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28671552/mid-term-clinical-outcomes-with-everolimus-eluting-bioresorbable-scaffolds-versus-everolimus-eluting-metallic-stents-for-percutaneous-coronary-interventions-a-meta-analysis-of-randomized-trials
#10
Salvatore Cassese, Byrne A Robert, Peter Jüni, Joanna J Wykrzykowska, Serban Puricel, Gjin Ndrepepa, Heribert Schunkert, Massimiliano Fusaro, Stephane Cook, Takeshi Kimura, Jose P S Henriques, Patrick W Serruys, Stephan Windecker, Adnan Kastrati
AIMS: To compare the mid-term clinical outcomes of patients treated with everolimus-eluting bioresorbable scaffold (BVS) versus everolimus-eluting metallic stent (EES) for percutaneous coronary intervention. METHODS AND RESULTS: We performed a meta-analysis of aggregate data by searching Medline, EMBASE, Cochrane databases and proceedings of international meetings for randomized trials reporting the clinical outcomes beyond 1 year of patients treated with BVS versus EES...
July 4, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28662808/arterial-remodeling-after-bioresorbable-scaffolds-and-metallic-stents
#11
RANDOMIZED CONTROLLED TRIAL
Patrick W Serruys, Yuki Katagiri, Yohei Sotomi, Yaping Zeng, Bernard Chevalier, René J van der Schaaf, Andreas Baumbach, Pieter Smits, Nicolas M van Mieghem, Antonio Bartorelli, Paul Barragan, Anthony Gershlick, Ran Kornowski, Carlos Macaya, John Ormiston, Jonathan Hill, Irene M Lang, Mohaned Egred, Jean Fajadet, Maciej Lesiak, Stephan Windecker, Robert A Byrne, Lorenz Räber, Robert-Jan van Geuns, Gary S Mintz, Yoshinobu Onuma
BACKGROUND: Although previous observational studies have documented late luminal enlargement and expansive remodeling following implantation of a bioresorbable vascular scaffold (BVS), no comparison with metallic stents has been conducted in a randomized fashion. OBJECTIVES: This study sought to compare vessel remodeling patterns after either Absorb BVS or Xience metallic drug-eluting stent (DES) implantation (Abbott Vascular, Santa Clara, California) and determine the independent predictors of remodeling...
July 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28658478/long-term-safety-and-efficacy-of-new-generation-drug-eluting-stents-in-women-with-acute-myocardial-infarction-from-the-women-in-innovation-and-drug-eluting-stents-win-des-collaboration
#12
Gennaro Giustino, Rafael Harari, Usman Baber, Samantha Sartori, Gregg W Stone, Martin B Leon, Stephan Windecker, Patrick W Serruys, Adnan Kastrati, Clemens Von Birgelen, Takeshi Kimura, Giulio G Stefanini, George D Dangas, William Wijns, P Gabriel Steg, Marie-Claude Morice, Edoardo Camenzind, Giora Weisz, Pieter C Smits, Sabato Sorrentino, Madhav Sharma, Serdar Farhan, Michela Faggioni, David Kandzari, Soren Galatius, Raban V Jeger, Marco Valgimigli, Dipti Itchhaporia, Laxmi Mehta, Hyo-Soo Kim, Alaide Chieffo, Roxana Mehran
Importance: Women with acute myocardial infarction (MI) undergoing mechanical reperfusion remain at increased risk of adverse cardiac events and mortality compared with their male counterparts. Whether the benefits of new-generation drug-eluting stents (DES) are preserved in women with acute MI remains unclear. Objective: To investigate the long-term safety and efficacy of new-generation DES vs early-generation DES in women with acute MI. Design, Setting, and Participants: Collaborative, international, individual patient-level data of women enrolled in 26 randomized clinical trials of DES were analyzed between July and December 2016...
August 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28625369/rationale-and-design-of-the-hunting-for-the-off-target-properties-of-ticagrelor-on-endothelial-function-and-other-circulating-biomarkers-in-humans-hi-tech-trial
#13
RANDOMIZED CONTROLLED TRIAL
Sara Ariotti, Maarten van Leeuwen, Salvatore Brugaletta, Sergio Leonardi, Kristiaan Martijn Akkerhuis, Emrush Rexhaj, Gladys Janssens, Luis Ortega-Paz, Diego Rizzotti, Jan C van den Berge, Dierik Heg, Gloria Francolini, Stephan Windecker, Marco Valgimigli
BACKGROUND: Among the 3 approved oral P2Y12 inhibitors for the treatment for patients with acute coronary syndrome (ACS), ticagrelor, but not prasugrel or clopidogrel, has been associated with off-target properties, such as improved endothelial-dependent vasomotion and increased adenosine plasma levels. METHODS: The HI-TECH study (NCT02587260) is a multinational, randomized, open-label, crossover study with a Latin squares design, conducted at 5 European sites, in which patients free from recurrent ischemic or bleeding events ≥30 days after a qualifying ACS were allocated to sequentially receive a 30 ± 5-day treatment with prasugrel, clopidogrel, and ticagrelor in random order...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28606888/neointima-and-neoatherosclerotic-characteristics-in-bare-metal-and-first-and-second-generation-drug-eluting-stents-in-patients-admitted-with-cardiovascular-events-attributed-to-stent-failure-an-optical-coherence-tomography-study
#14
Rodrigue Stettler, Jouke Dijkstra, Lorenz Räber, Ryo Torii, Yao-Jun Zhang, Antonis Karanasos, Shengnan Liu, Tom Crake, Steve Hamshere, Hector M Garcia-Garcia, Erhan Tenekecioglu, Muhiddin Ozkor, Stephan Windecker, Patrick W Serruys, Evelyn Regar, Anthony Mathur, Christos V Bourantas
AIMS: To assess neoatherosclerotic plaque morphology in bare metal (BMS) and 1st and 2nd generation drug eluting stents (DES) in patients presenting with an event attributed to stent failure. METHODS AND RESULTS: Thirty five patients (11 implanted with BMS, 13 with a 1st generation and 11 with a 2nd generation DES) admitted with an event due to stent failure who had neoatherosclerotic lesions on optical coherence tomography were included in the analysis. The lumen and stent borders were detected and the lipid and calcific tissue were identified in the neointima and their burden was estimated...
June 13, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28606165/pitfalls-in-tamvi-experience-with-the-repositionable-lotus%C3%A2-valve-system
#15
Paul P Heinisch, Fabien Praz, Bernhard Winkler, Stephan Windecker, Christoph Huber, Thierry Carrel
BACKGROUND: Simultaneous transapical implantation of transcatheter heart valves in the native mitral and aortic position may be considered as an alternative to surgical valve replacement in high-risk patients presenting with combined valve disease. CASE PRESENTATION: A 59-year-old female with severe aortic stenosis, severe mitral stenosis with mild mitral insufficiency, persistent atrial fibrillation, severe chronic obstructive pulmonary disease and NYHA class of IV was evaluated by our interdisciplinary heart team...
June 12, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28605779/use-of-the-dual-antiplatelet-therapy-score-to-guide-treatment-duration-after-percutaneous-coronary-intervention
#16
RANDOMIZED CONTROLLED TRIAL
Raffaele Piccolo, Giuseppe Gargiulo, Anna Franzone, Andrea Santucci, Sara Ariotti, Andrea Baldo, Carlo Tumscitz, Aris Moschovitis, Stephan Windecker, Marco Valgimigli
Background: The dual-antiplatelet therapy (DAPT) score was developed to identify patients more likely to derive harm (score <2) or benefit (score ≥2) from prolonged DAPT after percutaneous coronary intervention (PCI). Objective: To evaluate the safety and efficacy of DAPT duration according to DAPT score. Design: Retrospective assessment of DAPT score-guided treatment duration in a randomized clinical trial. (ClinicalTrials.gov: NCT00611286)...
July 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28570259/propensity-score-matched-comparison-of-the-cera-pfo-occluder-with-the-amplatzer-pfo-occluder-for-percutaneous-closure-of-patent-foramen-ovale-without-echocardiographic-guidance
#17
Mirjam Ulmi, Fabien Praz, George C M Siontis, Andreas Wahl, Stephan Windecker, Heinrich P Mattle, Bernhard Meier
BACKGROUND: Percutaneous patent foramen ovale (PFO) closure has become a routine procedure and was proven to be safe and feasible. In a recently published pooled analysis of randomized trials, percutaneous PFO closure was shown to more effectively reduce recurrent stroke when compared with medical therapy in patients with cryptogenic strokes. However, procedural safety and closure rate are device dependent. METHODS: We performed a propensity-score matched comparison of 28 patients undergoing percutaneous PFO closure using the Cera PFO occluder (CPO) with 28 patients who received the Amplatzer PFO occluder (APO)...
August 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28536005/effects-of-coronary-artery-disease-in-patients-undergoing-transcatheter-aortic-valve-implantation-a-study-of-age-and-gender-matched-cohorts
#18
Anna Franzone, Stefan Stortecky, Lorenz Räber, Dik Heg, Kyohei Yamaji, Raffaele Piccolo, Masahiko Asami, Jonas Lanz, Fabien Praz, Kostantinos Koskinas, Thomas Zanchin, Peter Wenaweser, Marco Valgimigli, Peter Jüni, Thomas Pilgrim, Stephan Windecker
BACKGROUND: The prognostic role of concomitant coronary artery disease (CAD) among patients undergoing transcatheter aortic valve implantation (TAVI) is still uncertain. METHODS: Data from the Bern TAVI Registry and the Bern PCI Registry were analyzed. Patients with concomitant CAD undergoing TAVI (TAVI+CAD) were age- and gender-matched to the following two cohorts: patients without CAD undergoing TAVI (TAVI-noCAD) and patients with stable CAD undergoing percutaneous coronary intervention (CAD-noAS)...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28528767/acute-kidney-injury-after-radial-or-femoral-access-for-invasive-acute-coronary-syndrome-management-aki-matrix
#19
Giuseppe Andò, Bernardo Cortese, Filippo Russo, Martina Rothenbühler, Enrico Frigoli, Giuseppe Gargiulo, Carlo Briguori, Pascal Vranckx, Sergio Leonardi, Vincenzo Guiducci, Flavia Belloni, Fabio Ferrari, Jose Maria de la Torre Hernandez, Salvatore Curello, Francesco Liistro, Andrea Perkan, Stefano De Servi, Gavino Casu, Antonio Dellavalle, Dionigi Fischetti, Antonio Micari, Bruno Loi, Fabio Mangiacapra, Nunzio Russo, Fabio Tarantino, Francesco Saia, Dik Heg, Stephan Windecker, Peter Jüni, Marco Valgimigli
BACKGROUND: It remains unclear whether radial access (RA), compared with femoral access (FA), mitigates the risk of acute kidney injury (AKI). OBJECTIVES: The authors assessed the incidence of AKI in patients with acute coronary syndrome (ACS) enrolled in the MATRIX-Access (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial. METHODS: Among 8,404 patients, 194 (2.3%) were excluded due to missing creatinine values, no or an incomplete coronary angiogram, or previous dialysis...
May 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28526547/no-significant-gender-difference-in-hospitalizations-for-acute-coronary-syndrome-in-switzerland-over-the-time-period-of-2001-to-2010
#20
Hugo Saner, Jannette D Mollet, Claudia Berlin, Stephan Windecker, Bernhard Meier, Lorenz Räber, Marcel Zwahlen, Petra Stute
BACKGROUND: Morbidity and mortality from cardiovascular diseases have decreased since the 1970s in most Western societies. However, it is unclear if this positive trend can also be found in younger women suffering from acute coronary syndrome (ACS). METHODS: This is a prospective single center registry study including 11.015 women and men hospitalized for a first ACS between the years 2001 and 2010. We analyzed ACS rates according to sex and age group using Poisson regression in order to assess temporal trends...
September 15, 2017: International Journal of Cardiology
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