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Stephan Windecker

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https://www.readbyqxmd.com/read/29338916/patent-foramen-ovale-closure-vs-medical-therapy-for-recurrent-stroke-prevention-evolution-of-treatment-effect-during-follow-up
#1
Raffaele Piccolo, Anna Franzone, George C M Siontis, Stefan Stortecky, Thomas Pilgrim, Bernhard Meier, Stephan Windecker
BACKGROUND: Little is known regarding changes in treatment effect over time associated with patent foramen ovale (PFO) closure among patients with embolic stroke of unknown origin. METHODS: We reconstructed Kaplan-Meier curves for stroke from individual randomized trials comparing PFO closure vs. medical therapy among patients with embolic stroke. Random effects Cox-regression analyses were performed in order to estimate hazard ratios (HRs) with 95% confidence intervals (95%CIs)...
January 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29331437/influence-of-operator-experience-and-pci-volume-on-transfemoral-access-techniques-a-collaboration-of-international-cardiovascular-societies
#2
Daniel W Nelson, Abdulla A Damluji, Nish Patel, Marco Valgimigli, Stephan Windecker, Robert Byrne, James Nolan, Tejas Patel, Emmanouil Brilakis, Subhash Banerjee, Jorge Mayol, Warren J Cantor, Carlos E Alfonso, Sunil V Rao, Mauro Moscucci, Mauricio G Cohen
INTRODUCTION: Transfemoral access (TFA) is widely used for coronary angiography and percutaneous coronary intervention (PCI). The influence of operator age, gender, experience, and procedural volume on performance of femoral arterial access has not been studied. METHODS: A survey instrument was developed and distributed via e-mail from professional societies to interventional cardiologists worldwide from March to December 2016. RESULTS: A total of 988 physicians from 88 countries responded to the survey...
December 27, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29311349/early-detection-of-subclinical-myocardial-damage-in-chronic-aortic-regurgitation-and-strategies-for-timely-treatment-of-asymptomatic-patients
#3
REVIEW
Joe K T Lee, Anna Franzone, Jonas Lanz, George C M Siontis, Stefan Stortecky, Christoph Gräni, Eva Roost, Stephan Windecker, Thomas Pilgrim
A series of hemodynamic and pathological responses occur in chronic aortic regurgitation, which eventually result in myocardial fibrosis and irreversible left ventricular dysfunction. According to guidelines, valvular surgery is recommended with the development of symptoms, left ventricular systolic dysfunction, or left ventricular dilatation. The optimal timing of surgical intervention has recently been questioned with documentation of irreversible myocardial damage resulting in incomplete left ventricular recovery and adverse clinical outcomes after surgery...
January 9, 2018: Circulation
https://www.readbyqxmd.com/read/29303795/nonejecting-hearts-on-femoral-veno-arterial-extracorporeal-membrane-oxygenation-aortic-root-blood-stasis-and-thrombus-formation-a-case-series-and-review-of-the-literature
#4
Hanane Hireche-Chikaoui, Martin R Grübler, Andreas Bloch, Stephan Windecker, Stefan Bloechlinger, Lukas Hunziker
OBJECTIVES: Cardiogenic shock constitutes the final common pathway of cardiac dysfunction associated with tissue hypoperfusion and organ failure. Besides treatment of the underlying cause, temporary mechanical circulatory support serves as a supportive measure. Extracorporeal membrane oxygenation can effectively prevent hypoxemia and end-organ dysfunction, but knowledge about patient selection, risks, and complications remains sparse. DATA SOURCES: Clinical observation...
January 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29301648/effect-of-increasing-stent-length-on-3-year-clinical-outcomes-in-women-undergoing-percutaneous-coronary-intervention-with-new-generation-drug-eluting-stents-patient-level-pooled-analysis-of-randomized-trials-from-the%C3%A2-win-des-initiative
#5
Jaya Chandrasekhar, Usman Baber, Samantha Sartori, Giulio G Stefanini, Michele Sarin, Birgit Vogel, Serdar Farhan, Edoardo Camenzind, Martin B Leon, Gregg W Stone, Patrick W Serruys, William Wijns, Philippe G Steg, Giora Weisz, Alaide Chieffo, Adnan Kastrati, Stephan Windecker, Marie-Claude Morice, Pieter C Smits, Clemens von Birgelen, Ghada W Mikhail, Dipti Itchhaporia, Laxmi Mehta, Hyo-Soo Kim, Marco Valgimigli, Raban V Jeger, Takeshi Kimura, Søren Galatius, David Kandzari, George Dangas, Roxana Mehran
OBJECTIVES: The aim of this study was to examine whether stent length per patient and stent length per lesion are negative markers for 3-year outcomes in women following percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (DES). BACKGROUND: In the era of advanced stent technologies, whether stent length remains a correlate of adverse outcomes is unclear. METHODS: Women treated with new-generation DES in 14 randomized trials from the WIN-DES (Women in Innovation and Drug-Eluting Stents) pooled database were evaluated...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29301646/impact-of-sex-on-comparative-outcomes-of-radial-versus-femoral-access-in-patients-with-acute-coronary-syndromes-undergoing-invasive-management-data-from-the-randomized-matrix-access-trial
#6
Giuseppe Gargiulo, Sara Ariotti, Pascal Vranckx, Sergio Leonardi, Enrico Frigoli, Nestor Ciociano, Carlo Tumscitz, Francesco Tomassini, Paolo Calabrò, Stefano Garducci, Gabriele Crimi, Giuseppe Andò, Maurizio Ferrario, Ugo Limbruno, Bernardo Cortese, Paolo Sganzerla, Alessandro Lupi, Filippo Russo, Roberto Garbo, Arturo Ausiello, Dennis Zavalloni, Gennaro Sardella, Giovanni Esposito, Andrea Santarelli, Simone Tresoldi, Marco Stefano Nazzaro, Antonio Zingarelli, Anna Sonia Petronio, Stephan Windecker, Bruno R da Costa, Marco Valgimigli
OBJECTIVES: This study sought to assess whether transradial access (TRA) compared with transfemoral access (TFA) is associated with consistent outcomes in male and female patients with acute coronary syndrome undergoing invasive management. BACKGROUND: There are limited and contrasting data about sex disparities for the safety and efficacy of TRA versus TFA for coronary intervention. METHODS: In the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) program, 8,404 patients were randomized to TRA or TFA...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29277234/special-article-2017-esc-focused-update-on-dual-antiplatelet-therapy-in-coronary-artery-disease-developed-in-collaboration-with-eacts
#7
Marco Valgimigli, Héctor Bueno, Robert A Byrne, Jean-Philippe Collet, Francesco Costa, Anders Jeppsson, Peter Jüni, Adnan Kastrati, Philippe Kolh, Laura Mauri, Gilles Montalescot, Franz-Josef Neumann, Mate Petricevic, Marco Roffi, Philippe Gabriel Steg, Stephan Windecker, José Luis Zamorano
No abstract text is available yet for this article.
January 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29275399/new-onset-arrhythmias-following-transcatheter-aortic-valve-implantation-a-systematic-review-and-meta-analysis
#8
George C M Siontis, Fabien Praz, Jonas Lanz, René Vollenbroich, Laurent Roten, Stefan Stortecky, Lorenz Räber, Stephan Windecker, Thomas Pilgrim
OBJECTIVE: To evaluate the prevalence and clinical impact of new-onset arrhythmias in patients following transcatheter aortic valve implantation (TAVI). METHOD: We systematically identified studies reporting new-onset arrhythmias after TAVI other than atrioventricular conduction disturbances. We summarised monitoring strategies, type and prevalence of arrhythmias and estimated their effect on risk of death or cerebrovascular events by using random-effects meta-analysis...
December 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29275371/stent-and-dual-antiplatelet-therapy-duration-comparisons-in-the-setting-of-a-multicenter-randomized-controlled-trial-can-the-operator-experience-affect-the-study-results
#9
Giuseppe Gargiulo, Dik Heg, Fabrizio Ferrari, Gianfranco Percoco, Gianluca Campo, Carlo Tumscitz, Federico Colombo, Andrea Zuffi, Fausto Castriota, Alberto Cremonesi, Stephan Windecker, Marco Valgimigli
BACKGROUND: Operator experience influences outcomes after percutaneous coronary intervention, but this association in the controlled setting of a randomized, clinical trial is unclear. METHODS AND RESULTS: We investigated operator-related outcomes (30-day and 2-year efficacy and safety end points) among patients undergoing percutaneous coronary intervention and randomized to different dual antiplatelet therapy durations and stent types. A total of 2003 patients were analyzed, and 7 operator groups were compared...
December 23, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29251754/2017-esc-focused-update-on-dual-antiplatelet-therapy-in-coronary-artery-disease-developed-in-collaboration-with-eacts
#10
Marco Valgimigli, Héctor Bueno, Robert A Byrne, Jean-Philippe Collet, Francesco Costa, Anders Jeppsson, Peter Jüni, Adnan Kastrati, Philippe Kolh, Laura Mauri, Gilles Montalescot, Franz-Josef Neumann, Mate Peticevic, Marco Roffi, Philippe Gabriel Steg, Stephan Windecker, Jose Luis Zamorano
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29248412/effects-of-body-mass-index-on-clinical%C3%A2-outcomes-in-female-patients-undergoing-percutaneous-coronary-intervention-with-drug-eluting-stents-results-from-a-patient-level-pooled-analysis-of-randomized%C3%A2-controlled-trials
#11
Michela Faggioni, Usman Baber, Arash Ehteshami Afshar, Gennaro Giustino, Samantha Sartori, Sabato Sorrentino, Philippe G Steg, Giulio G Stefanini, Stephan Windecker, Martin B Leon, Gregg W Stone, William Wijns, Patrick W Serruys, Marco Valgimigli, Edoardo Camenzind, Giora Weisz, Pieter C Smits, David E Kandzari, Soren Galatius, Clemens Von Birgelen, Raban V Jeger, Ghada W Mikhail, Dipti Itchhaporia, Laxmi Mehta, Rebecca Ortega, Hyo-Soo Kim, Adnan Kastrati, Alaide Chieffo, George D Dangas, Marie-Claude Morice, Roxana Mehran
OBJECTIVES: This study sought to investigate the effect of different body mass index (BMI) categories on clinical outcomes in female patients treated with percutaneous coronary intervention (PCI) and drug-eluting stents. BACKGROUND: Patients with higher BMI might, paradoxically, have better long-term clinical outcomes after acute coronary syndrome treated with PCI. METHODS: We pooled patient-level data for female participants from 26 randomized trials on PCI with drug-eluting stents...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29222592/circadian-dependence-of-manual-thrombus-aspiration-benefit-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#12
Stephane Fournier, Olivier Muller, Umberto Benedetto, Marco Roffi, Thomas Pilgrim, Franz R Eberli, Hans Rickli, Dragana Radovanovic, Paul Erne, Stéphane Cook, Stéphane Noble, Rachel Fesselet, Andrea Zuffi, Sophie Degrauwe, PierGiorgio Masci, Stephan Windecker, Eric Eeckhout, Juan F Iglesias
BACKGROUND: The clinical benefit of manual thrombus aspiration (TA) during primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains uncertain. This study assessed the impact of circadian rhythms on the effectiveness of manual TA. METHODS AND RESULTS: We conducted an observational study of patients enrolled in the Acute Myocardial Infarction in Switzerland Plus registry. STEMI patients undergoing PPCI with (TA group) or without (PCI-alone group) manual TA were divided based on time-of-day symptom onset: group 1 (00:00-05:59), group 2 (06:00-11:59), group 3 (12:00-17:59) and group 4 (18:00-23:59)...
December 8, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29206961/corrigendum-to-2017-esc-eacts-guidelines-for-the-management-of-valvular-heart-disease-eur-j-cardiothorac-surg-2017-52-616-664
#13
Volkmar Falk, Helmut Baumgartner, Jeroen J Bax, Michele De Bonis, Christian Hamm, Per Johan Holm, Bernard Iung, Patrizio Lancellotti, Emmanuel Lansac, Daniel Rodriguez Muñoz, Raphael Rosenhek, Johan Sjögren, Pilar Tornos Mas, Alec Vahanian, Thomas Walther, Olaf Wendler, Stephan Windecker, Jose Luis Zamorano, Marco Roffi, Ottavio Alfieri, Stefan Agewall, Anders Ahlsson, Emanuele Barbato, Héctor Bueno, Jean-Philippe Collet, Ioan Mircea Coman, Martin Czerny, Victoria Delgado, Donna Fitzsimons, Thierry Folliguet, Oliver Gaemperli, Gilbert Habib, Wolfgang Harringer, Michael Haude, Gerhard Hindricks, Hugo A Katus, Juhani Knuuti, Philippe Kolh, Christophe Leclercq, Theresa A McDonagh, Massimo Francesco Piepoli, Luc A Pierard, Piotr Ponikowski, Giuseppe M C Rosano, Frank Ruschitzka, Evgeny Shlyakhto, Iain A Simpson, Miguel Sousa-Uva, Janina Stepinska, Giuseppe Tarantini, Didier Tchétché, Victor Aboyans
No abstract text is available yet for this article.
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29205157/a-comparison-of-an-ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stent-with-a-durable-polymer-everolimus-eluting-stent-for-patients-with-acute-stsegment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-rationale
#14
Juan F Iglesias, Olivier Muller, Serge Zaugg, Marco Roffi, David J Kurz, André Vuilliomenet, Daniel Weilenmann, Christoph Kaiser, Maxime Tapponnier, Dik Heg, Marco Valgimigli, Eric Eeckhout, Peter Jüni, Stephan Windecker, Thomas Pilgrim
AIMS: A novel ultrathin-strut biodegradable polymer sirolimus-eluting stent (Orsiro™, Biotronik, Bülach, Switzerland; BP-SES) was shown to be superior to a thin-strut durable polymer everolimus-eluting stent (Xience™ Xpedition/Alpine, Abbott Vascular, Santa Clara, USA; DP-EES) with respect to the primary endpoint of target lesion failure (TLF) at 12 months in the prespecified subgroup of patients with ST-segment elevation myocardial infarction (STEMI) included in the BIOSCIENCE trial...
December 5, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29169496/transfemoral-approach-for-coronary%C3%A2-angiography-and-intervention-a-collaboration-of-international-cardiovascular-societies
#15
Abdulla A Damluji, Daniel W Nelson, Marco Valgimigli, Stephan Windecker, Robert A Byrne, Fernando Cohen, Tejas Patel, Emmanouil S Brilakis, Subhash Banerjee, Jorge Mayol, Warren J Cantor, Carlos E Alfonso, Sunil V Rao, Mauro Moscucci, Mauricio G Cohen
OBJECTIVES: The aim of this study was to examine the current practice and use of transfemoral approach (TFA) for coronary angiography and intervention. BACKGROUND: Wide variability exists in TFA techniques for coronary procedures. METHODS: The authors developed a survey instrument that was distributed via e-mail lists from professional societies to interventional cardiologists from 88 countries between March and December 2016. RESULTS: Of 987 operators, 18% were femoralists, 38% radialists, 42% both, and 2% neither...
November 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29156023/2017-esc-eacts-guidelines-for-the-management-of-valvular-heart-disease
#16
Volkmar Falk, Helmut Baumgartner, Jeroen J Bax, Michele De Bonis, Christian Hamm, Per Johan Holm, Bernard Iung, Patrizio Lancellotti, Emmanuel Lansac, Daniel Rodriguez Muñoz, Raphael Rosenhek, Johan Sjögren, Pilar Tornos Mas, Alec Vahanian, Thomas Walther, Olaf Wendler, Stephan Windecker, Jose Luis Zamorano
No abstract text is available yet for this article.
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155984/cysteine-rich-angiogenic-inducer-61-cyr61-a-novel-soluble-biomarker-of-acute-myocardial-injury-improves-risk-stratification-after-acute-coronary-syndromes
#17
Roland Klingenberg, Soheila Aghlmandi, Christoph Liebetrau, Lorenz Räber, Baris Gencer, David Nanchen, David Carballo, Alexander Akhmedov, Fabrizio Montecucco, Stefan Zoller, Chad Brokopp, Dik Heg, Peter Jüni, Helena Marti Soler, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Oliver Dörr, Nicolas Rodondi, François Mach, Stephan Windecker, Ulf Landmesser, Arnold von Eckardstein, Christian W Hamm, Christian M Matter, Thomas F Lüscher
Aims: We aimed to identify a novel biomarker involved in the early events leading to an acute coronary syndrome (ACS) and evaluate its role in diagnosis and risk stratification. Methods and results: Biomarker identification was based on gene expression profiling. In coronary thrombi of ACS patients, cysteine-rich angiogenic inducer 61 (Cyr61, CCN1) gene transcripts were highly up-regulated compared with peripheral mononuclear cells. In a murine ischaemia-reperfusion model (I/R), myocardial Cyr61 expression was markedly increased compared with the controls...
November 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29153244/outcomes-of-transcatheter-tricuspid-valve-in-valve-implantation-in-patients-with-ebstein-anomaly
#18
Nathaniel W Taggart, Allison K Cabalka, Andreas Eicken, Jamil A Aboulhosn, John D R Thomson, Brian Whisenant, Martin L Bocks, Stephan Schubert, Thomas K Jones, Jeremy D Asnes, Thomas E Fagan, Jeffery Meadows, Mark Hoyer, Mary H Martin, Frank F Ing, Daniel R Turner, Azeem Latib, Aphrodite Tzifa, Stephan Windecker, Bryan H Goldstein, Jeffrey W Delaney, James A Kuo, Susan Foerster, Matthew Gillespie, Gianfranco Butera, Shabana Shahanavaz, Eric Horlick, Younes Boudjemline, Daniel Dvir, Doff B McElhinney
We sought to describe the acute results and short- to medium-term durability of transcatheter tricuspid valve-in-valve (TVIV) implantation within surgical bioprostheses among patients with Ebstein anomaly (EA). Cases were identified from a voluntary, multicenter, international registry of 29 institutions that perform TVIV. Demographic, clinical, procedural, and follow-up data were analyzed. Eighty-one patients with EA underwent TVIV from 2008 to 2016. Thirty-four patients (42%) were New York Heart Association (NYHA) class 3/4 at time of TVIV...
January 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29151436/pcr-london-valves-innovators-day-2017-where-will-valve-intervention-be-in-2025
#19
Sam Dawkins, Thomas Modine, Stephan Windecker, Nicolo Piazza, Bernard D Prendergast
No abstract text is available yet for this article.
November 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29132156/low-dose-aspirin-to-reduce-the-risk-for-myocardial-infarction-among-patients-with-coronary-stents-undergoing-noncardiac-surgery
#20
Raffaele Piccolo, Stephan Windecker
No abstract text is available yet for this article.
November 14, 2017: Annals of Internal Medicine
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