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Stephan Windecker

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https://www.readbyqxmd.com/read/29156023/2017-esc-eacts-guidelines-for-the-management-of-valvular-heart-disease
#1
Volkmar Falk, Helmut Baumgartner, Jeroen J Bax, Michele De Bonis, Christian Hamm, Per Johan Holm, Bernard Iung, Patrizio Lancellotti, Emmanuel Lansac, Daniel Rodriguez Muñoz, Raphael Rosenhek, Johan Sjögren, Pilar Tornos Mas, Alec Vahanian, Thomas Walther, Olaf Wendler, Stephan Windecker, Jose Luis Zamorano
No abstract text is available yet for this article.
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155984/cysteine-rich-angiogenic-inducer-61-cyr61-a-novel-soluble-biomarker-of-acute-myocardial-injury-improves-risk-stratification-after-acute-coronary-syndromes
#2
Roland Klingenberg, Soheila Aghlmandi, Christoph Liebetrau, Lorenz Räber, Baris Gencer, David Nanchen, David Carballo, Alexander Akhmedov, Fabrizio Montecucco, Stefan Zoller, Chad Brokopp, Dik Heg, Peter Jüni, Helena Marti Soler, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Oliver Dörr, Nicolas Rodondi, François Mach, Stephan Windecker, Ulf Landmesser, Arnold von Eckardstein, Christian W Hamm, Christian M Matter, Thomas F Lüscher
Aims: We aimed to identify a novel biomarker involved in the early events leading to an acute coronary syndrome (ACS) and evaluate its role in diagnosis and risk stratification. Methods and results: Biomarker identification was based on gene expression profiling. In coronary thrombi of ACS patients, cysteine-rich angiogenic inducer 61 (Cyr61, CCN1) gene transcripts were highly up-regulated compared with peripheral mononuclear cells. In a murine ischaemia-reperfusion model (I/R), myocardial Cyr61 expression was markedly increased compared with the controls...
November 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29153244/outcomes-of-transcatheter-tricuspid-valve-in-valve-implantation-in-patients-with-ebstein-anomaly
#3
Nathaniel W Taggart, Allison K Cabalka, Andreas Eicken, Jamil A Aboulhosn, John D R Thomson, Brian Whisenant, Martin L Bocks, Stephan Schubert, Thomas K Jones, Jeremy D Asnes, Thomas E Fagan, Jeffery Meadows, Mark Hoyer, Mary H Martin, Frank F Ing, Daniel R Turner, Azeem Latib, Aphrodite Tzifa, Stephan Windecker, Bryan H Goldstein, Jeffrey W Delaney, James A Kuo, Susan Foerster, Matthew Gillespie, Gianfranco Butera, Shabana Shahanavaz, Eric Horlick, Younes Boudjemline, Daniel Dvir, Doff B McElhinney
We sought to describe the acute results and short- to medium-term durability of transcatheter tricuspid valve-in-valve (TVIV) implantation within surgical bioprostheses among patients with Ebstein anomaly (EA). Cases were identified from a voluntary, multicenter, international registry of 29 institutions that perform TVIV. Demographic, clinical, procedural, and follow-up data were analyzed. Eighty-one patients with EA underwent TVIV from 2008 to 2016. Thirty-four patients (42%) were New York Heart Association (NYHA) class 3/4 at time of TVIV...
October 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29151436/pcr-london-valves-innovators-day-2017-where-will-valve-intervention-be-in-2025
#4
Sam Dawkins, Thomas Modine, Stephan Windecker, Nicolo Piazza, Bernard D Prendergast
No abstract text is available yet for this article.
November 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29132156/low-dose-aspirin-to-reduce-the-risk-for-myocardial-infarction-among-patients-with-coronary-stents-undergoing-noncardiac-surgery
#5
Raffaele Piccolo, Stephan Windecker
No abstract text is available yet for this article.
November 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29127116/predicting-mortality-after-transcatheter-aortic-valve-replacement-external-validation-of-the-transcatheter-valve-therapy-registry-model
#6
Thomas Pilgrim, Anna Franzone, Stefan Stortecky, Fabian Nietlispach, Alan G Haynes, David Tueller, Stefan Toggweiler, Oliver Muller, Enrico Ferrari, Stéphane Noble, Francesco Maisano, Raban Jeger, Marco Roffi, Jürg Grünenfelder, Christoph Huber, Peter Wenaweser, Stephan Windecker
BACKGROUND: The Transcatheter Valve Therapy (TVT) registry model was recently developed to predict the risk of in-hospital mortality in patients undergoing transcatheter aortic valve replacement. We sought to externally validate the model in an independent data set of consecutively enrolled patients in the Swiss Transcatheter Aortic Valve Implantation registry. METHODS AND RESULTS: The original prediction model was retrospectively applied to 3491 consecutive patients undergoing transcatheter aortic valve replacement in Switzerland between February 2011 and February 2016...
November 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29122809/eligibility-for-pcsk9-inhibitors-according-to-american-college-of-cardiology-acc-and-european-society-of-cardiology-european-atherosclerosis-society-esc-eas-guidelines-after-acute-coronary-syndromes
#7
Baris Gencer, Konstantinos C Koskinas, Lorenz Räber, Alexios Karagiannis, David Nanchen, Reto Auer, David Carballo, Sebastian Carballo, Roland Klingenberg, Dik Heg, Christian M Matter, Thomas F Lüscher, Nicolas Rodondi, François Mach, Stephan Windecker
BACKGROUND: The American College of Cardiology (ACC) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) have recently published recommendations for the use of proprotein convertase subtilisin/kexin-9 (PCSK9) inhibitors in situations of very high risk. We aim to assess in the real world the suitability of PCSK9 inhibitors for acute coronary syndromes. METHODS AND RESULTS: We analyzed a prospective Swiss cohort of 2023 patients hospitalized for acute coronary syndromes between 2009 and 2014 with available data for low-density lipoprotein cholesterol and lipid-lowering therapy at 1 year...
November 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29118880/occurrence-and-impact-of-time-delay-to-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction
#8
Mohammady Shahin, Slayman Obeid, Lotfy Hamed, Christian Templin, Oliver Gamperli, Fabian Nietlispach, Willbald Maier, Nooraldaem Yousif, Francois Mach, Marco Roffi, Stephan Windecker, Lorenz Raber, Christian M Matter, Thomas F Luscher
Background: The aim of the study was to evaluate the occurrence, duration and impact of time delays to primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI). Methods: A total of 357 consecutive STEMI patients enrolled in the prospective Special Program University Medicine ACS (SPUM-ACS) cohort were included. In order to identify the causes behind a possible treatment delay, we constructed four different time points which included: 1) symptom onset to hospital arrival, 2) hospital arrival to arrival in the catheterization laboratory, 3) hospital arrival to first balloon inflation, and 4) time from arrival in the catheterization laboratory to first balloon inflation in addition to total ischemic time...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29096803/mechanisms-of-very-late-bioresorbable%C3%A2-scaffold-thrombosis-the-invest-registry
#9
Kyohei Yamaji, Yasushi Ueki, Geraud Souteyrand, Joost Daemen, Jens Wiebe, Holger Nef, Tom Adriaenssens, Joshua P Loh, Benoit Lattuca, Joanna J Wykrzykowska, Josep Gomez-Lara, Leo Timmers, Pascal Motreff, Petra Hoppmann, Mohamed Abdel-Wahab, Robert A Byrne, Felix Meincke, Niklas Boeder, Benjamin Honton, Crochan J O'Sullivan, Alfonso Ielasi, Nicolas Delarche, Günter Christ, Joe K T Lee, Michael Lee, Nicolas Amabile, Alexios Karagiannis, Stephan Windecker, Lorenz Räber
BACKGROUND: Very late scaffold thrombosis (VLScT) occurs more frequently after bioresorbable scaffold (Absorb BVS 1.1, Abbott Vascular, Santa Clara, California) implantation than with metallic everolimus-eluting stents. OBJECTIVES: The purpose of this study was to elucidate mechanisms underlying VLScT as assessed by optical coherence tomography (OCT). METHODS: The INVEST (Independent OCT Registry on Very Late Bioresorbable Scaffold Thrombosis) registry is an international consortium of investigators who used OCT to examine patients with VLScT...
November 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29094677/four-year-follow-up-of-the-randomised-comparison-between-an-everolimus-eluting-bioresorbable-scaffold-and-an-everolimus-eluting-metallic-stent-for-the-treatment-of-coronary-artery-stenosis-absorb-ii-trial
#10
Bernard Chevalier, Angel Cequier, Dariusz Dudek, Michael Haude, Didier Carrie, Manel Sabaté, Stephan Windecker, Sebastian Reith, Manuel de Sousa Almeida, Gianluca Campo, Andres Iñiguez, Yoshi Onuma, Patrick W Serruys
AIMS: No randomised comparison data are available beyond the resorption of the everolimus-eluting bioresorbable scaffold. Absorb is expected to be completely resorbed by 3 years. The purpose of this report is to provide the 4 year results of a randomised, single blind, multicentre evaluation of Absorb versus the metallic stent Xience (Abbott Vascular, Santa Clara, CA, USA). METHODS AND RESULTS: Three-year follow-up has been previously published. Patients re-consented for additional follow-up up through to 5 years; 86% (N=289) and 84% (N=139) of whom underwent a 4 year follow-up visit...
October 31, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29083953/pci-strategies-in-patients-with-acute-myocardial-infarction-and-cardiogenic-shock
#11
Holger Thiele, Ibrahim Akin, Marcus Sandri, Georg Fuernau, Suzanne de Waha, Roza Meyer-Saraei, Peter Nordbeck, Tobias Geisler, Ulf Landmesser, Carsten Skurk, Andreas Fach, Harald Lapp, Jan J Piek, Marko Noc, Tomaž Goslar, Stephan B Felix, Lars S Maier, Janina Stepinska, Keith Oldroyd, Pranas Serpytis, Gilles Montalescot, Olivier Barthelemy, Kurt Huber, Stephan Windecker, Stefano Savonitto, Patrizia Torremante, Christiaan Vrints, Steffen Schneider, Steffen Desch, Uwe Zeymer
Background In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock have multivessel disease, and whether PCI should be performed immediately for stenoses in nonculprit arteries is controversial. Methods In this multicenter trial, we randomly assigned 706 patients who had multivessel disease, acute myocardial infarction, and cardiogenic shock to one of two initial revascularization strategies: either PCI of the culprit lesion only, with the option of staged revascularization of nonculprit lesions, or immediate multivessel PCI...
October 30, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29069377/effect-of-statins-and-non-statin-ldl-lowering-medications-on-cardiovascular-outcomes-in-secondary-prevention-a-meta-analysis-of-randomized-trials
#12
Konstantinos C Koskinas, George C M Siontis, Raffaele Piccolo, Dimitris Mavridis, Lorenz Räber, François Mach, Stephan Windecker
Aims: Current evidence on dyslipidaemia management has expanded to novel treatments and very low achieved levels of low-density lipoprotein cholesterol (LDL-C). We sought to compare the clinical impact of more-intensive vs. less-intensive LDL-C lowering by means of statins and currently recommended non-statin medications in secondary prevention. Methods and results: We searched Medline, EMBASE, and Cochrane databases for randomized controlled trials of statins, ezetimibe, proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, or bile acid sequestrants with >500 patients followed for ≥1 year...
October 23, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29045644/2017-update-of-esc-eas-task-force-on-practical-clinical-guidance-for-proprotein-convertase-subtilisin-kexin-type-9-inhibition-in-patients-with-atherosclerotic-cardiovascular-disease-or-in-familial-hypercholesterolaemia
#13
Ulf Landmesser, M John Chapman, Jane K Stock, Pierre Amarenco, Jill J F Belch, Jan Borén, Michel Farnier, Brian A Ference, Stephan Gielen, Ian Graham, Diederick E Grobbee, G Kees Hovingh, Thomas F Lüscher, Massimo F Piepoli, Kausik K Ray, Erik S Stroes, Olov Wiklund, Stephan Windecker, Jose Luis Zamorano, Fausto Pinto, Lale Tokgözoglu, Jeroen J Bax, Alberico L Catapano
No abstract text is available yet for this article.
October 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29045581/2017-esc-focused-update-on-dual-antiplatelet-therapy-in-coronary-artery-disease-developed-in-collaboration-with-eacts-the-task-force-for-dual-antiplatelet-therapy-in-coronary-artery-disease-of-the-european-society-of-cardiology-esc-and-of-the-european-association
#14
Marco Valgimigli, Héctor Bueno, Robert A Byrne, Jean-Philippe Collet, Francesco Costa, Anders Jeppsson, Peter Jüni, Adnan Kastrati, Philippe Kolh, Laura Mauri, Gilles Montalescot, Franz-Josef Neumann, Mate Petricevic, Marco Roffi, Philippe Gabriel Steg, Stephan Windecker, Jose Luis Zamorano, Glenn N Levine
No abstract text is available yet for this article.
August 26, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29044383/the-european-society-of-cardiology-clinical-practice-guidelines
#15
Stephan Windecker
No abstract text is available yet for this article.
September 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020413/incidence-predictors-and-clinical-outcomes-of-coronary-obstruction-following-transcatheter-aortic-valve-replacement-for-degenerative-bioprosthetic-surgical-valves-insights-from-the-vivid-registry
#16
Henrique B Ribeiro, Josep Rodés-Cabau, Philipp Blanke, Jonathon Leipsic, Jong Kwan Park, Vinayak Bapat, Raj Makkar, Matheus Simonato, Marco Barbanti, Joachim Schofer, Sabine Bleiziffer, Azeem Latib, David Hildick-Smith, Patrizia Presbitero, Stephan Windecker, Massimo Napodano, Alfredo G Cerillo, Mohamed Abdel-Wahab, Didier Tchetche, Claudia Fiorina, Jan-Malte Sinning, Mauricio G Cohen, Mayra E Guerrero, Brian Whisenant, Fabian Nietlispach, José Honório Palma, Luis Nombela-Franco, Arend de Weger, Malek Kass, Fabio Sandoli de Brito, Pedro A Lemos, Ran Kornowski, John Webb, Danny Dvir
Aims: There are limited data on coronary obstruction following transcatheter valve-in-valve (ViV) implantation inside failed aortic bioprostheses. The objectives of this study were to determine the incidence, predictors, and clinical outcomes of coronary obstruction in transcatheter ViV procedures. Methods and results: A total of 1612 aortic procedures from the Valve-in-Valve International Data (VIVID) Registry were evaluated. Data were subject to centralized blinded corelab computed tomography (CT) analysis in a subset of patients...
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020344/standardized-definitions-of-structural-deterioration-and-valve-failure-in-assessing-long-term-durability-of-transcatheter-and-surgical-aortic-bioprosthetic-valves-a-consensus-statement-from-the-european-association-of-percutaneous-cardiovascular-interventions
#17
Davide Capodanno, Anna S Petronio, Bernard Prendergast, Helene Eltchaninoff, Alec Vahanian, Thomas Modine, Patrizio Lancellotti, Lars Sondergaard, Peter F Ludman, Corrado Tamburino, Nicolò Piazza, Jane Hancock, Julinda Mehilli, Robert A Byrne, Andreas Baumbach, Arie Pieter Kappetein, Stephan Windecker, Jeroen Bax, Michael Haude
No abstract text is available yet for this article.
July 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020333/thrombo-embolic-prevention-after-transcatheter-aortic-valve-implantation
#18
Pascal Vranckx, Stephan Windecker, Robert C Welsh, Marco Valgimigli, Roxana Mehran, George Dangas
Transcatheter aortic valve implantation (TAVI) has emerged as a valuable treatment alternative to surgical aortic valve replacement among patients with symptomatic aortic stenosis at increased surgical risk. The rapid technological evolution from early to current-generation TAVI systems with low-profile delivery catheters, bioprosthetic valves with proven midterm durability, and improved positioning and retrieval features have made important contributions to the widespread clinical use of this minimal invasive therapy...
July 25, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020259/report-of-an-esc-eapci-task-force-on-the-evaluation-and-use-of-bioresorbable-scaffolds-for-percutaneous-coronary-intervention-executive-summary
#19
Robert A Byrne, Giulio G Stefanini, Davide Capodanno, Yoshinobu Onuma, Andreas Baumbach, Javier Escaned, Michael Haude, Stefan James, Michael Joner, Peter Jüni, Adnan Kastrati, Semih Oktay, William Wijns, Patrick W Serruys, Stephan Windecker
A previous Task Force of the European Society of Cardiology (ESC) and European Association of Percutaneous Cardiovascular Interventions (EAPCI) provided a report on recommendations for the non-clinical and clinical evaluation of coronary stents. Following dialogue with the European Commission, the Task Force was asked to prepare an additional report on the class of devices known as bioresorbable scaffolds (BRS). Five BRS have CE-mark approval for use in Europe. Only one device-the Absorb bioresorbable vascular scaffold-has published randomized clinical trial data and this data show inferior outcomes to conventional drug-eluting stents (DES) at 2-3 years...
August 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28993000/incidence-and-impact-of-renal-dysfunction-on-clinical-outcomes-after-transcatheter-aortic-valve-implantation
#20
Anna Franzone, Stefan Stortecky, Thomas Pilgrim, Masahiko Asami, Jonas Lanz, Dik Heg, Bettina Langhammer, Raffaele Piccolo, Joe K T Lee, Fabien Praz, Lorenz Räber, Marco Valgimigli, Eva Roost, Stephan Windecker
BACKGROUND: The impact of baseline renal dysfunction on early and late clinical outcomes after transcatheter aortic valve implantation (TAVI) remains to be defined. METHODS: 927 patients included in the prospective Bern TAVI registry were classified on the basis of the baseline estimated glomerular filtration rate (eGFR), as having none or mild (eGFR ≥60mL/min/1.73m(2), n=284, 30.6%), moderate (eGFR between 30 and 59mL/min/1.73m(2), n=535, 57.7%) and severe (eGFR <30mL/min/1...
October 3, 2017: International Journal of Cardiology
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