keyword
MENU ▼
Read by QxMD icon Read
search

Simulation medicine

keyword
https://www.readbyqxmd.com/read/29453808/three-dimensional-printing-in-congenital-heart-disease-a-systematic-review
#1
REVIEW
Ivan Lau, Zhonghua Sun
Three-dimensional (3D) printing has shown great promise in medicine with increasing reports in congenital heart disease (CHD). This systematic review aims to analyse the main clinical applications and accuracy of 3D printing in CHD, as well as to provide an overview of the software tools, time and costs associated with the generation of 3D printed heart models. A search of different databases was conducted to identify studies investigating the application of 3D printing in CHD. Studies based on patient's medical imaging datasets were included for analysis, while reports on in vitro phantom or review articles were excluded from the analysis...
February 17, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29451901/the-novel-antibiotic-rhodomyrtone-traps-membrane-proteins-in-vesicles-with-increased-fluidity
#2
Dennapa Saeloh, Varomyalin Tipmanee, Kin Ki Jim, Marien P Dekker, Wilbert Bitter, Supayang P Voravuthikunchai, Michaela Wenzel, Leendert W Hamoen
The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinical applications, very little is known about the mechanism of action of rhodomyrtone. Preceding studies have been focused on intracellular targets, but no specific intracellular protein could be confirmed as main target. Using live cell, high-resolution, and electron microscopy we demonstrate that rhodomyrtone causes large membrane invaginations with a dramatic increase in fluidity, which attract a broad range of membrane proteins...
February 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29450830/personalized-medicine-and-pay-for-performance-should-pharmaceutical-firms-be-fully-penalized-when-treatment-fails
#3
Fernando Antoñanzas, Roberto Rodríguez-Ibeas, Carmelo A Juárez-Castelló
In this article, we model the behavior of a pharmaceutical firm that has marketing authorization for a new therapy believed to be a candidate for personalized use in a subset of patients, but that lacks information as to why a response is seen only in some patients. We characterize the optimal outcome-based reimbursement policy a health authority should follow to encourage the pharmaceutical firm to undertake research and development activities to generate the information needed to effectively stratify patients...
February 15, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29448168/simultaneous-determination-of-magnolol-and-honokiol-by-amino-acid-ionic-liquid-synchronous-fluorescence-spectrometry
#4
Wei Liu, Xiashi Zhu
A novel method based on amino acid ionic liquids (AAILs) as an additive synchronous fluorescence spectrometry is proposed for simultaneous determination of magnolol (MN) and honokiol (HN) in traditional Chinese medicine Houpu. The overlapping fluorescence spectrum of MN and HN could be completely separated in the AAILs medium. Experiment parameters (the type and concentration of AAILs, pH values and temperature) were discussed. The detection limits of MN and HN reached 1.46ng/mL, 0.92ng/mL and the recovery rates ranged from 98...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29447154/examining-the-controllability-of-sepsis-using-genetic-algorithms-on-an-agent-based-model-of-systemic-inflammation
#5
Robert Chase Cockrell, Gary An
Sepsis, a manifestation of the body's inflammatory response to injury and infection, has a mortality rate of between 28%-50% and affects approximately 1 million patients annually in the United States. Currently, there are no therapies targeting the cellular/molecular processes driving sepsis that have demonstrated the ability to control this disease process in the clinical setting. We propose that this is in great part due to the considerable heterogeneity of the clinical trajectories that constitute clinical "sepsis," and that determining how this system can be controlled back into a state of health requires the application of concepts drawn from the field of dynamical systems...
February 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29445882/procedure-rates-performed-by-emergency-medicine-residents-a-retrospective-review
#6
Joshua T Bucher, Christopher Bryczkowski, Grant Wei, Renee L Riggs, Anoop Kotwal, Brian Sumner, Jonathan V McCoy
BACKGROUND: The purpose of our study is to investigate rates of individual procedures performed by residents in our emergency medicine (EM) residency program. Different programs expose residents to different training environments. Our hypothesis is that ultrasound examinations are the most commonly performed procedure in our residency. METHODS: The study took place in an academic level I trauma center with multiple residency and fellowship programs including surgery, surgical critical care, trauma, medicine, pulmonary/critical care, anesthesiology and others...
February 14, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29441344/implementation-of-a-sustainable-training-system-for-emergency-in-vietnam
#7
REVIEW
Sunjoo Kang, Hyejin Seo, Binh Duy Ho, Phuong Thi Anh Nguyen
Purpose: This study analyzed the project outcomes to share lessons regarding the development of an emergency medicine education system in Vietnam. Methods: Retrospective evaluation was implemented using project outcome indicators. Results: A total of 13 training courses were administered, with the collaboration of international experts in Korea and Vietnam. A total of 23 kinds of emergency medicine education equipment were purchased, and a basic life support (BLS) and two advanced cardiac life support labs were remodeled to provide appropriate simulation training...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29440215/does-exposure-to-simulated-patient-cases-improve-accuracy-of-clinicians-predictive-value-estimates-of-diagnostic-test-results-a-within-subjects-experiment-at-st-michael-s-hospital-toronto-canada
#8
Bonnie Armstrong, Julia Spaniol, Nav Persaud
OBJECTIVE: Clinicians often overestimate the probability of a disease given a positive test result (positive predictive value; PPV) and the probability of no disease given a negative test result (negative predictive value; NPV). The purpose of this study was to investigate whether experiencing simulated patient cases (ie, an 'experience format') would promote more accurate PPV and NPV estimates compared with a numerical format. DESIGN: Participants were presented with information about three diagnostic tests for the same fictitious disease and were asked to estimate the PPV and NPV of each test...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29436940/biomarker-threshold-adaptive-designs-for-survival-endpoints
#9
Guoqing Diao, Jun Dong, Donglin Zeng, Chunlei Ke, Alan Rong, Joseph G Ibrahim
Due to the importance of precision medicine, it is essential to identify the right patients for the right treatment. Biomarkers, which have been commonly used in clinical research as well as in clinical practice, can facilitate selection of patients with a good response to the treatment. In this paper, we describe a biomarker threshold adaptive design with survival endpoints. In the first stage, we determine subgroups for one or more biomarkers such that patients in these subgroups benefit the most from the new treatment...
February 13, 2018: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/29435856/modern-theories-of-pelvic-floor-support-a-topical-review-of-modern-studies-on-structural-and-functional-pelvic-floor-support-from-medical-imaging-computational-modeling-and-electromyographic-perspectives
#10
REVIEW
Yun Peng, Brandi D Miller, Timothy B Boone, Yingchun Zhang
PURPOSE OF REVIEW: Weakened pelvic floor support is believed to be the main cause of various pelvic floor disorders. Modern theories of pelvic floor support stress on the structural and functional integrity of multiple structures and their interplay to maintain normal pelvic floor functions. Connective tissues provide passive pelvic floor support while pelvic floor muscles provide active support through voluntary contraction. Advanced modern medical technologies allow us to comprehensively and thoroughly evaluate the interaction of supporting structures and assess both active and passive support functions...
February 12, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29433996/gelatin-thoracic-paravertebral-teaching-model-for-placement-of-a-continuous-infusion-catheter-in-the-extrathoracic-paravertebral-space
#11
Shruti Sevak, Ashley Woodfin, Zachary Hothem, Rose Callahan, James Robbins, Kathryn Ziegler
OBJECTIVE: Our aim was to develop an ultrasound-guided training curriculum for continuous infusion catheter placement in the paravertebral space and to create a gelatin thoracic spine-rib model for use in this training. We sought to create a model that was inexpensive and reusable such that multiple participants could use one model during training. DESIGN: The model was prepared by embedding a firm foam thoracic spine replica with bilateral attached ribs into an opaque gelatin mixture...
February 9, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29433307/role-of-hepatic-organic-anion-transporter-2-in-the-pharmacokinetics-of-r-and-s-warfarin-in-vitro-studies-and-mechanistic-evaluation
#12
Yi-An Bi, Jian Lin, Sumathy Mathialagan, Laurie Tylaska, Ernesto Callegari, A David Rodrigues, Manthena V S Varma
Inter-individual variability in warfarin dose requirement demands personalized medicine approaches to balance its therapeutic benefits (anticoagulation) and bleeding risk. Cytochrome P450 2C9 (CYP2C9) genotype-guided warfarin dosing is recommended in the clinic, given the more potent S-warfarin is primarily metabolized by CYP2C9. However, only about 20-30% of inter-patient variability in S-warfarin clearance is associated with CYP2C9 genotype. We evaluated the role of hepatic uptake in the clearance of R- and S-warfarin...
February 12, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29431423/osmosis-driven-motion-type-modulation-of-biological-nanopores-for-parallel-optical-nucleic-acid-sensing
#13
Yuqin Wang, Shuanghong Yan, Pan-Ke Zhang, Zidao Zeng, Di Zhao, Jiaxin Wang, Hong-Yuan Chen, Shuo Huang
Recent developments in nanopore sequencing have inspired new concepts in precision medicine but limited in throughput. By optically encoding calcium flux from an array of nanopores, parallel measurements from hundreds of nanopores were reported while lateral drifts of biological nanopores set obstacles for signal processing. In this paper, optical single channel recording (oSCR) serves to track nanopores with high precision and a general principle of nanopore motion kinetics is quantitatively investigated. By finely adjusting the osmosis oriented interactions between the lipid/substrate interfaces,motions of nanopores could be controllably restricted...
February 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29426258/validation-of-the-self-assessment-teamwork-tool-satt-in-a-cohort-of-nursing-and-medical-students
#14
Lucinda Roper, Boaz Shulruf, Christine Jorm, Jane Currie, Christopher J Gordon
INTRODUCTION: Poor teamwork has been implicated in medical error and teamwork training has been shown to improve patient care. Simulation is an effective educational method for teamwork training. Post-simulation reflection aims to promote learning and we have previously developed a self-assessment teamwork tool (SATT) for health students to measure teamwork performance. This study aimed to evaluate the psychometric properties of a revised self-assessment teamwork tool. METHODS: The tool was tested in 257 medical and nursing students after their participation in one of several mass casualty simulations...
February 9, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29425647/predicting-tyrosinase-inhibition-by-3d-qsar-pharmacophore-models-and-designing-potential-tyrosinase-inhibitors-from-traditional-chinese-medicine-database
#15
Hongwei Gao
BACKGROUND: Tyrosinase plays a key role in the formation of skin melanin. The excessive accumulation of skin melanin will cause the serious aesthetic problems for human beings. HYPOTHESIS/PURPOSE: To find the potent tyrosinase inhibitors using computational simulation from TCM Database@Taiwan. STUDY DESIGN: Inhibitors of tyrosinase have been thought as potential drugs for the decrease of melanin synthesis in the process of pigmentation. To develop new tyrosinase inhibitors, we performed a virtual screening from Traditional Chinese medicine (TCM) and Druglike Databases using the best 3D QSAR pharmacophore model as a 3D search query...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29422890/embelin-restores-carbapenem-efficacy-against-ndm-1-positive-pathogens
#16
Nian-Zhi Ning, Xiong Liu, Fanghong Chen, Peng Zhou, Lihong Hu, Jian Huang, Zhan Li, Jie Huang, Tao Li, Hui Wang
The emergence and spread of carbapenemase in Gram-negative pathogens poses an enormous threat to global public health. New Delhi metallo-β-lactamase-1 (NDM-1) inactivates nearly every class of β-lactam antibiotics, including carbapenem; however, there is no clinically useful NDM-1 inhibitor. Embelin, an important ingredient in traditional herbal medicine, has anti-tumor effects. The current study is the first to discover and examine the inhibitory activity of embelin against β-lactamase NDM-1. The IC50 of embelin was 2...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29421708/characterization-and-structure-activity-relationship-studies-of-flavonoids-as-inhibitors-against-human-carboxylesterase-2
#17
Zi-Miao Weng, Guang-Bo Ge, Tong-Yi Dou, Ping Wang, Ping-Kun Liu, Xin-Hui Tian, Nan Qiao, Yang Yu, Li-Wei Zou, Qi Zhou, Wei-Dong Zhang, Jie Hou
Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily. Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the metabolic activation of ester drugs including irinotecan and flutamide. Selective and potent hCE2 inhibitors could be used to alleviate the toxicity induced by hCE2-substrate drugs. In this study, more than fifty flavonoids were collected to assay their inhibitory effects against hCE2 using a fluorescence-based method. The results demonstrated that C3 and C6 hydroxy groups were essential for hCE2 inhibition, while O-glycosylation or C-glycosylation would lead to the loss of hCE2 inhibition...
January 9, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29420330/promoting-interprofessional-collaborative-practice-through-simulation
#18
Celeste M Alfes, Tonya Rutherford-Hemming, Casey M Schroeder-Jenkinson, Cynthia Booth Lord, Elizabeth Zimmermann
A 12-week program was developed to educate nursing, medicine, and physician assistant faculty on the principles and best practices of simulation. The goal was to facilitate team building and collaborative practice through the implementation of an interprofessional (IP) simulation experience for students. Workshops focused on IP communication involving seminar-based instruction, discussion, and the progressive development of an IP simulation based on a National League for Nursing Advancing Care Excellence for Seniors scenario...
February 7, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29413847/abstract-id-103-gamos-implementation-of-a-graphical-user-interface-for-dosimetry-calculation-in-radiotherapy
#19
Faical Alaoui Abdalaoui Slimani, M'hamed Bentourkia
There are several computer programs or combination of programs for radiation tracking and other information in tissues by using Monte Carlo simulation [1]. Among these are GEANT4 [2] programs provided as classes that can be incorporated in C++ codes to achieve different tasks in radiation interactions with matter. GEANT4 made the physics easier but requires often a long learning-curve that implies a good knowledge of C++ and the Geant4 architecture. GAMOS [3], the Geant4-based Architecture for Medicine-Oriented Simulations, facilitates the use of Geant4 by providing a script language that covers almost all the needs of a radiotherapy simulation but it is obviously out of reach of biological researchers...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29412098/leadership-in-crisis-situations-merging-the-interdisciplinary-silos
#20
Hugo Paquin, Ilana Bank, Meredith Young, Lily H P Nguyen, Rachel Fisher, Peter Nugus
Purpose Complex clinical situations, involving multiple medical specialists, create potential for tension or lack of clarity over leadership roles and may result in miscommunication, errors and poor patient outcomes. Even though copresence has been shown to overcome some differences among team members, the coordination literature provides little guidance on the relationship between coordination and leadership in highly specialized health settings. The purpose of this paper is to determine how different specialties involved in critical medical situations perceive the role of a leader and its contribution to effective crisis management, to better define leadership and improve interdisciplinary leadership and education...
February 5, 2018: Leadership in Health Services
keyword
keyword
27672
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"