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Simulation medicine

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https://www.readbyqxmd.com/read/29679784/a-swinging-seesaw-as-a-novel-model-mechanism-for-time-dependent-hormesis-under-dose-dependent-stimulatory-and-inhibitory-effects-a-case-study-on-the-toxicity-of-antibacterial-chemicals-to-aliivibrio-fischeri
#1
Haoyu Sun, Edward J Calabrese, Min Zheng, Dali Wang, Yongzheng Pan, Zhifen Lin, Ying Liu
Hormesis occurs frequently in broadly ranging biological areas (e.g. plant biology, microbiology, biogerontology), toxicology, pharmacology and medicine. While numerous mechanisms (e.g. receptor and pathway mediated pathway responses) account for stimulatory and inhibitory features of hormetic dose responses, the vast majority emphasizes the inclusion of many doses but only one timepoint or use of a single optimized dose that is assessed over a broad range of timepoints. In this paper, a toxicity study was designed using a large number of properly spaced doses with responses determined over a large number of timepoints, which could help us reveal the underlying mechanism of hormesis...
April 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679721/effectiveness-evaluation-of-digital-virtual-simulation-application-in-teaching-of-gross-anatomy
#2
Xiaohua Deng, Guowei Zhou, Bing Xiao, Zirui Zhao, Yicheng He, Chujun Chen
INTRODUCTION: digital virtual simulation (DVS) is increasingly used to supplement the teaching of anatomy. DVS can provide the students with three-dimensional (3D) stereoscopic images and precise structures in anatomy teaching. We investigated the effects of digital virtual simulation (DVS) application in gross anatomy teaching. MATERIALS AND METHODS: fourth-year medical students (n=120), majoring clinical medicine in 2013 grade from Xiangya School of Medicine, Central South University, were assigned into four classes...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29679255/needle-tissue-interactive-mechanism-and-steering-control-in-image-guided-robot-assisted-minimally-invasive-surgery-a-review
#3
Pan Li, Zhiyong Yang, Shan Jiang
Image-guided robot-assisted minimally invasive surgery is an important medicine procedure used for biopsy or local target therapy. In order to reach the target region not accessible using traditional techniques, long and thin flexible needles are inserted into the soft tissue which has large deformation and nonlinear characteristics. However, the detection results and therapeutic effect are directly influenced by the targeting accuracy of needle steering. For this reason, the needle-tissue interactive mechanism, path planning, and steering control are investigated in this review by searching literatures in the last 10 years, which results in a comprehensive overview of the existing techniques with the main accomplishments, limitations, and recommendations...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29678077/use-of-system-dynamics-modeling-in-medical-education-and-research-projects
#4
Jadranka Bozikov, Danko Relic, Gjuro Dezelic
The paper reviews experiences and accomplishments in application of system dynamics modeling in education, training and research projects at the Andrija Stampar School of Public Health, a branch of the Zagreb University School of Medicine, Croatia. A number of simulation models developed over the past 40 years are briefly described with regard to real problems concerned, objectives and modeling methods and techniques used. Many of them have been developed as the individual students' projects as a part of their graduation, MSc or PhD theses and subsequently published in journals or conference proceedings...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677402/ultrafast-adiabatic-photodehydration-of-o-hydroxymethylphenol-and-formation-of-quinone-methide
#5
Nikola Basaric, Djani Skalamera, Ivana Antol, Kata Mlinaric Majerski, Hrvoj Vancik, David Lee Phillips, Jiani Ma
Photochemical reactivity of 2-hydroxymethylphenol (1) has been investigated experimentally by photochemistry at cryogenic conditions and the detection of reactive intermediates by IR, and the nanosecond and femtosecond transient absorption spectroscopic methods in solutions at room temperature. In addition, theoretical studies were performed to facilitate the interpretation of the experimental results and also to simulate the reaction pathway for a better understanding of the reaction mechanism. The main finding of this work is that photodehydration of 1 takes place in an ultrafast adiabatic photochemical reaction without any obvious intermediate, delivering quinone methide (QM) in the excited state...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29677043/the-effects-of-interprofessional-pediatric-end-of-life-simulation-on-communication-and-role-understanding-in-health-professions-students
#6
Jacqueline Stout-Aguilar, Alison Pittman, Regina Bentley, Jerry Livingston, Bree Watzak
The purpose of this study was to analyze the impact of interprofessional pediatric end-of life simulations for health professions students. A quasiexperimental design was used with three TeamSTEPPS® tools. Forty-one students were enrolled (nursing = 20, medicine = 10, pharmacy = 10, public health = 1). TeamSTEPPS 2.0 Teamwork Attitudes Questionnaire and Teamwork Perceptions Questionnaire analysis indicated a significant difference in mean pretest and posttest scores (p = .015 and p = .028, respectively). The Team Performance Observation Tool indicated statistical significance between simulations (p < ...
April 19, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29676618/cancer-risk-from-paediatric-computed-tomography-scanning-implications-for-radiation-protection-in-medicine
#7
A Kesminiene, E Cardis
The use of computed tomography (CT) imaging is clearly beneficial for millions of patients. However, the potential adverse health effects, particularly cancer, of ionising radiation exposure from CT early in life are an issue of growing concern in the radiological protection, medical, and public health communities. Although efforts to quantify these effects have been conducted, the precision and accuracy of reported risks needs confirmation. EPI-CT, a European collaborative epidemiological study, was set up to quantify risks from paediatric CT to optimise paediatric diagnostic protocol...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29675639/pharmacokinetic-pharmacodynamic-modeling-in-pediatric-drug-development-and-the-importance-of-standardized-scaling-of-clearance
#8
REVIEW
Eva Germovsek, Charlotte I S Barker, Mike Sharland, Joseph F Standing
Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and conduct of clinical pharmacology research in children. During drug development, PKPD modeling and simulation should underpin rational trial design and facilitate extrapolation to investigate efficacy and safety. The application of PKPD modeling to optimize dosing recommendations and therapeutic drug monitoring is also increasing, and PKPD model-based dose individualization will become a core feature of personalized medicine. Following extensive progress on pediatric PK modeling, a greater emphasis now needs to be placed on PD modeling to understand age-related changes in drug effects...
April 19, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29675530/hepatoprotective-activity-of-iridoids-seco-iridoids-and-analog-glycosides-from-gentianaceae-on-hepg2-cells-via-cyp3a4-induction-and-mitochondrial-pathway
#9
Kang Dai, Xue-Jia Yi, Xian-Ju Huang, Azhar Muhammad, Mei Li, Jun Li, Guang-Zhong Yang, Yue Gao
Gentianaceae herb extracts have been widely used as food additives, teas or medicinal remedies for various diseases and disorders of the human body. Herein, the potential effects of iridoids, seco-iridoids and analog glycosides from gentian on acontine-induced hepatotoxicity were investigated in HepG2 cells to obtain metabolic data of drug-biotarget interactions. Molecular docking analysis was performed to assess the binding efficiencies of 53 iridoids, seco-iridoids and analog compounds obtained from 50 gentian species to the active sites of human CYP3A4 enzyme...
April 20, 2018: Food & Function
https://www.readbyqxmd.com/read/29667640/-the-efficiency-of-the-application-of-the-modern-computed-technologies-in-the-clinical-practice-and-the-prospects-for-the-further-use-of-the-biomechanical-3d-models-in-forensic-medicine
#10
I Yu Makarov, A V Svetlakov, A V Sotin, S V Shigeev, A A Gusarov, S A Smirenin, V V Emelin, V B Stragis, V A Fetisov
To-day, the computer-assisted 3D-technologies for the mathematical simulation of the engineering facilities are extensively used for the purpose of technical calculations in all branches of industry and building. The positive experience gained with the application of the 3D-models finds wide application in the joined investigations on the topical problems of the prosthetic and surgical treatment of bones, teeth, joints, cardiac valves, blood vessels, etc. The objective of the present study was the analysis of the positive experience with the involvement of the specialists in the design and practical application of 3D-models for the solution of problems facing the medical prosthetics and the management of various pathological conditions...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667466/evaluation-of-a-modified-16-item-readiness-for-interprofessional-learning-scale-ripls-exploratory-and-confirmatory-factor-analyses
#11
Tzu-Chieh Yu, Tanisha Jowsey, Marcus Henning
The Readiness for Interprofessional Learning Scale (RIPLS) was developed to assess undergraduate readiness for engaging in interprofessional education (IPE). It has become an accepted and commonly used instrument. To determine utility of a modified 16-item RIPLS instrument, exploratory and confirmatory factor analyses were performed. Data used were collected from a pre- and post-intervention study involving 360 New Zealand undergraduate students from one university. Just over half of the participants were enrolled in medicine (51%) while the remainder were in pharmacy (27%) and nursing (22%)...
April 18, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29666754/empirical-evaluation-of-data-normalization-methods-for-molecular-classification
#12
Huei-Chung Huang, Li-Xuan Qin
Background: Data artifacts due to variations in experimental handling are ubiquitous in microarray studies, and they can lead to biased and irreproducible findings. A popular approach to correct for such artifacts is through post hoc data adjustment such as data normalization. Statistical methods for data normalization have been developed and evaluated primarily for the discovery of individual molecular biomarkers. Their performance has rarely been studied for the development of multi-marker molecular classifiers-an increasingly important application of microarrays in the era of personalized medicine...
2018: PeerJ
https://www.readbyqxmd.com/read/29662914/ligament-strain-response-between-lower-extremity-contralateral-pairs-during-in-vitro-landing-simulation
#13
April L McPherson, Nathanial A Bates, Nathan D Schilaty, Christopher V Nagelli, Aaron J Krych, Timothy E Hewett
Background: Limb asymmetries, as determined through in vivo biomechanical measures, are known risk factors for anterior cruciate ligament (ACL) injury. Previous cadaveric studies have shown a lack of significant differences in ligament strain between contralateral lower extremities when identical kinematics were simulated on specimens. Recent methodological developments have applied in vivo knee kinetics to exert landing forces on cadaveric lower extremities to mimic ACL injury events, but it is unknown whether contralateral limbs fail in a consistent manner during impact simulator testing...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29662297/graphics-processing-unit-enhanced-genetic-algorithms-for-solving-the-temporal-dynamics-of-gene-regulatory-networks
#14
REVIEW
Raúl García-Calvo, J L Guisado, Fernando Diaz-Del-Rio, Antonio Córdoba, Francisco Jiménez-Morales
Understanding the regulation of gene expression is one of the key problems in current biology. A promising method for that purpose is the determination of the temporal dynamics between known initial and ending network states, by using simple acting rules. The huge amount of rule combinations and the nonlinear inherent nature of the problem make genetic algorithms an excellent candidate for finding optimal solutions. As this is a computationally intensive problem that needs long runtimes in conventional architectures for realistic network sizes, it is fundamental to accelerate this task...
2018: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/29658407/c-mix-a-high-dimensional-mixture-model-for-censored-durations-with-applications-to-genetic-data
#15
Simon Bussy, Agathe Guilloux, Stéphane Gaïffas, Anne-Sophie Jannot
We introduce a supervised learning mixture model for censored durations (C-mix) to simultaneously detect subgroups of patients with different prognosis and order them based on their risk. Our method is applicable in a high-dimensional setting, i.e. with a large number of biomedical covariates. Indeed, we penalize the negative log-likelihood by the Elastic-Net, which leads to a sparse parameterization of the model and automatically pinpoints the relevant covariates for the survival prediction. Inference is achieved using an efficient Quasi-Newton Expectation Maximization algorithm, for which we provide convergence properties...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29656610/fipronil-recognition-by-the-fa1-site-of-human-serum-albumin
#16
Paolo Ascenzi, Loris Leboffe, Daniele Toti, Fabio Polticelli, Viviana Trezza
Fipronil is a broad-spectrum pesticide widely used in agriculture, horticulture, and forestry. Because fipronil can cause a variety of toxic effects in animals and humans, its use is authorized as a pesticide in veterinary medicinal products for pets, but not for the treatment of livestock animals whose products are intended for consumption. Recently, however, the presence of fipronil residues has been detected in the eggs and meat of layer hens from farms located in different European countries. Given the relevance of fipronil toxicity for human health, it is important to gain information concerning its fate in the human body, including its binding mode to human serum albumin (HSA), the most abundant protein in plasma...
April 15, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29655687/the-inhibitory-potential-of-broussochalcone-a-for-the-human-cytochrome-p450-2j2-isoform-and-its-anti-cancer-effects-via-foxo3-activation
#17
See-Hyoung Park, Jongsung Lee, Jong Cheol Shon, Nguyen Minh Phuc, Jun Goo Jee, Kwang-Hyeon Liu
BACKGROUND: Broussonetia papyrifera (L.) Ventenat, a traditional medicinal herb, has been applied as a folk medicine to treat various diseases. Broussochalcone A (BCA), a chalcone compound isolated from the cortex of Broussonetia papyrifera (L.) Ventenat, exhibits several biological activities including potent anti-oxidant, antiplatelet, and cytotoxic effects. PURPOSE: The purpose of this study is to elucidate the inhibitory effect of BCA against CYP2J2 enzyme which is predominantly expressed in human tumor tissues and carcinoma cell lines...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652750/a-needs-assessment-of-brain-death-education-in-pediatric-critical-care-medicine-fellowships
#18
Andrew M Ausmus, Pippa M Simpson, Liyun Zhang, Tara L Petersen
OBJECTIVES: To assess the current training in brain death examination provided during pediatric critical care medicine fellowship. DESIGN: Internet-based survey. SETTING: United States pediatric critical care medicine fellowship programs. SUBJECTS: Sixty-four pediatric critical care medicine fellowship program directors and 230 current pediatric critical care medicine fellows/recent graduates were invited to participate...
April 12, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29650810/-artificial-intelligence-in-drug-discovery
#19
Takeshi Fujiwara, Mayumi Kamada, Yasushi Okuno
According to the increase of data generated from analytical instruments, application of artificial intelligence(AI)technology in medical field is indispensable. In particular, practical application of AI technology is strongly required in "genomic medicine" and "genomic drug discovery" that conduct medical practice and novel drug development based on individual genomic information. In our laboratory, we have been developing a database to integrate genome data and clinical information obtained by clinical genome analysis and a computational support system for clinical interpretation of variants using AI...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650483/solid-cystic-and-tubular-novice-ultrasound-skills-training-using-a-versatile-affordable-practice-model
#20
Shruti Sevak, Benjamin Lurvey, Ashley A Woodfin, Zachary Hothem, Rose E Callahan, James Robbins, Kathryn Ziegler
OBJECTIVE: In spite of the recognized benefits of ultrasound, many physicians have little experience with using ultrasound to perform procedures. Many medical schools and residency programs lack a formal ultrasound training curriculum. We describe an affordable ultrasound training curriculum and versatile, inexpensive practice model. DESIGN: Participants underwent a didactic session to teach the theory required to perform ultrasound-guided procedures. Motor skills were taught using a practice model incorporating analogs of common anatomic and pathologic structures into an opacified gelatin substrate...
April 9, 2018: Journal of Surgical Education
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