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Simulation medicine

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https://www.readbyqxmd.com/read/28643447/simultaneous-mapping-of-metabolites-and-individual-macromolecular-components-via-ultra-short-acquisition-delay-1-h-mrsi-in-the-brain-at-7t
#1
Michal Považan, Bernhard Strasser, Gilbert Hangel, Eva Heckova, Stephan Gruber, Siegfried Trattnig, Wolfgang Bogner
PURPOSE: Short-echo-time proton MR spectra at 7T feature nine to 10 distinct macromolecule (MM) resonances that overlap with the signals of metabolites. Typically, a metabolite-nulled in vivo MM spectrum is included in the quantification`s prior knowledge to provide unbiased metabolite quantification. However, this MM model may fail if MMs are pathologically altered. In addition, information about the individual MM peaks is lost. In this study, we aimed to create an improved MM model by parameterization of the in vivo MM spectrum into individual components, and to use this new model to quantify free induction decay MR spectroscopic imaging (FID-MRSI) data...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28643408/the-effect-of-concomitant-fields-in-fast-spin-echo-acquisition-on-asymmetric-mri-gradient-systems
#2
Shengzhen Tao, Paul T Weavers, Joshua D Trzasko, John Huston, Yunhong Shu, Erin M Gray, Thomas K F Foo, Matt A Bernstein
PURPOSE: To investigate the effect of the asymmetric gradient concomitant fields (CF) with zeroth and first-order spatial dependence on fast/turbo spin-echo acquisitions, and to demonstrate the effectiveness of their real-time compensation. METHODS: After briefly reviewing the CF produced by asymmetric gradients, the effects of the additional zeroth and first-order CFs on these systems are investigated using extended-phase graph simulations. Phantom and in vivo experiments are performed to corroborate the simulation...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28643347/off-resonance-based-assessment-of-metallic-wear-debris-near-total-hip-arthroplasty
#3
Kevin M Koch, Matthew F Koff, Thomas W Bauer, Parina H Shah, Andrew S Nencka, S Sivaram Kaushik, Hollis G Potter
PURPOSE: The presence of metallic debris near total hip arthroplasty can have a significant impact on longitudinal patient management. Methods for magnetic resonance imaging-based quantification of metallic debris near painful total hip replacements are described and applied to cohorts of symptomatic and control subject cases. METHODS: A combination of metal artifact reduction, off-resonance mapping, off-resonance background removal, and spatial clustering methods are utilized to quantify off-resonance signatures in cases of suspected metallosis...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28643003/recent-developments-in-solution-nuclear-magnetic-resonance-nmr-based-molecular-biology
#4
REVIEW
Joshua J Ziarek, Diego Baptista, Gerhard Wagner
Visualizing post-translational modifications, conformations, and interaction surfaces of protein structures at atomic resolution underpins the development of novel therapeutics to combat disease. As computational resources expand, in silico calculations coupled with experimentally derived structures and functional assays have led to an explosion in structure-based drug design (SBDD) with several compounds in clinical trials. It is increasingly clear that "hidden" transition-state structures along activation trajectories can be harnessed to develop novel classes of allosteric inhibitors...
June 23, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28640230/total-flavonoids-of-drynariae-rhizoma-prevent-bone-loss-induced-by-hindlimb-unloading-in-rats
#5
Shuanghong Song, Ziyang Gao, Xujun Lei, Yinbo Niu, Yuan Zhang, Cuiqin Li, Yi Lu, Zhezhi Wang, Peng Shang
Drynariae Rhizoma is a kidney-tonifying herb that has a long history in clinical practice for the treatment of bone fractures and joint diseases in China. Flavonoids are considered to be its major active ingredients and are reported to ease bone loss in ovariectomized rats. However, the beneficial effects of the total flavonoids of Drynariae Rhizoma on osteoporosis caused by microgravity or mechanical inactivity remain unknown. This study assessed the effects of total Drynariae Rhizoma flavonoids (DRTF, Qihuang, Beijing, China, national medicine permit No...
June 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28640034/using-a-simulation-of-a-frustrated-faculty-member-during-department-chair-searches-a-proof-of-concept-project
#6
Daniel E Shapiro, Lisa M Abbott, Daniel R Wolpaw, Michael J Green, Benjamin H Levi
PROBLEM: Vitae reviews, interviews, presentations, and reference checks are typical components of searches used to screen and select new department chairs/heads, but these strategies may fail to identify leaders who can communicate effectively with faculty in common, tense situations. APPROACH: Between May 2015 and November 2016, the authors piloted simulation scenarios in four department chair searches at Penn State College of Medicine/Penn State Health to assess candidates' skill at handling common, challenging situations with faculty members...
June 20, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28639069/the-application-of-3d-printing-technology-for-simultaneous-orthognathic-surgery-and-mandibular-contour-osteoplasty-in-the-treatment-of-craniofacial-deformities
#7
Yanju Xiao, Xiumei Sun, Lin Wang, Yaoyao Zhang, Kai Chen, Guomin Wu
BACKGROUND: Because of the limitation of specific preoperative design and surgical templates, orthognathic surgery and mandibular contour osteoplasty are generally performed in two stages. Three-dimensional printing technology has improved the accuracy of the surgery and results in good surgical predictability easily. This study aims to confirm the effectiveness, feasibility and precision of simultaneous mandibular contour osteoplasty and orthognathic surgery with the assistance of 3D printing technology...
June 21, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28638171/3d-printed-abdominal-aortic-aneurysm-phantom-for-image-guided-surgical-planning-with-a-patient-specific-fenestrated-endovascular-graft-system
#8
Karen M Meess, Richard L Izzo, Maciej L Dryjski, Richard E Curl, Linda M Harris, Michael Springer, Adnan H Siddiqui, Stephen Rudin, Ciprian N Ionita
Following new trends in precision medicine, Juxatarenal Abdominal Aortic Aneurysm (JAAA) treatment has been enabled by using patient-specific fenestrated endovascular grafts. The X-ray guided procedure requires precise orientation of multiple modular endografts within the arteries confirmed via radiopaque markers. Patient-specific 3D printed phantoms could familiarize physicians with complex procedures and new devices in a risk-free simulation environment to avoid periprocedural complications and improve training...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28636403/applying-precision-medicine-to-trial-design-using-physiology-extracorporeal-co2-removal-for-ards
#9
Ewan C Goligher, Marcelo B P Amato, Arthur S Slutsky
In clinical trials of therapies for ARDS, the average treatment effect in the study population may be attenuated because individual patient responses vary widely. This inflates sample size requirements and increases the cost and difficulty of conducting successful clinical trials. One solution is to enrich the study population with patients most likely to benefit based on predicted patient response to treatment (predictive enrichment). In this perspective, we apply the precision medicine paradigm to the emerging use of extracorporeal CO2 removal (ECCO2R) for ultra-protective ventilation in ARDS...
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28634679/establishment-of-two-forensic-medicine-osce-stations-on-the-subject-of-external-post-mortem-examination
#10
S Heide, R Lessig, V Hachmann, D Stiller, M Rönsch, D Stoevesandt, A Biolik, S Watzke, J Kellner
An improvement in quality of medical external post-mortem examinations among others can be achieved by more intensive training of medical students. Modern learning and teaching methods such as e-learning modules and SkillsLab stations should be used for this. The introduction of corresponding methods of assessment such as the OSCE procedure is necessary to test the success of learning. In Halle (Germany), two OSCE stations on the subject of external post-mortem examinations were introduced in 2016. The 'practical external post-mortem examination' station test skills and abilities students have learned during practical external post-mortem examination in small group classes on a simulation doll...
June 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28632015/the-associations-between-clerkship-objective-structured-clinical-examination-osce-grades-and-subsequent-performance
#11
Ting Dong, Christopher Zahn, Aaron Saguil, Kimberly A Swygert, Michelle Yoon, Jessica Servey, Steven Durning
Construct: We investigated the extent of the associations between medical students' clinical competency measured by performance in Objective Structured Clinical Examinations (OSCE) during Obstetrics/Gynecology and Family Medicine clerkships and later performance in both undergraduate and graduate medical education. BACKGROUND: There is a relative dearth of studies on the correlations between undergraduate OSCE scores and future exam performance within either undergraduate or graduate medical education and almost none on linking these simulated encounters to eventual patient care...
March 2, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28631897/the-interaction-mode-of-groove-binding-between-quercetin-and-calf-thymus-dna-based-on-spectrometry-and-simulation
#12
Yijie Sha, Xu Chen, Bing Niu, Qin Chen
Quercetin, a ubiquitous flavanoid, has numerous pharmacological effects, such as antioxidant and antitumor. Previous studies showed nucleic acids were the potential biological targets for antitumor medicine. For exploring the mechanism of DNA-target medicine, the interaction between quercetin and calf thymus DNA was studied based on the method of spectrometry and simulation in our study. Firstly, the interaction between quercetin and calf thymus DNA was confirmed by fluorescence spectrometry. Furthermore, circular dichroism, fluorescence polarization, competitive displacement assay and salt concentration dependence assay were applied to search the interaction mode of quercetin-calf thymus DNA, which proved the existence of groove binding and electrostatic interaction...
June 20, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28631337/a-method-to-assess-the-loss-of-a-dipole-antenna-for-ultra-high-field-mri
#13
Gang Chen, Christopher M Collins, Daniel K Sodickson, Graham C Wiggins
PURPOSE: To describe a new bench measurement based on quality (Q) factors to estimate the coil noise relative to the sample noise of dipole antennas at 7 T. METHODS: Placing a dipole antenna close to a highly conductive sample surrogate (HCSS) greatly reduces radiation loss, and using QHCSS gives a more accurate estimate of coil resistance than Qunloaded . Instead of using the ratio of unloaded and sample-loaded Q factors, the ratio of HCSS-loaded and sample-loaded Q factors should be used at ultra-high fields...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28629581/impact-of-a-teamstepps-trauma-nurse-academy-at-a-level-1-trauma-center
#14
V Kristen Peters, Ellen M Harvey, Andi Wright, Jennifer Bath, Dan Freeman, Bryan Collier
PROBLEM: Nurses are crucial members of the team caring for the acutely injured trauma patient. Until recently, nurses and physicians gained an understanding of leadership and supportive roles separately. With the advent of a multidisciplinary team approach to trauma care, formal team training and simulation has transpired. METHODS: Since 2007, our Level I trauma system has integrated TeamSTEPPS (Team Strategies & Tools to Enhance Performance & Patient Safety; Agency for Healthcare Research and Quality, Rockville, MD) into our clinical care, joint training of nurses and physicians, using simulations with participation of all health care providers...
June 16, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28629264/a-comparative-study-of-subgroup-identification-methods-for-differential-treatment-effect-performance-metrics-and-recommendations
#15
Demissie Alemayehu, Yang Chen, Marianthi Markatou
Subgroup identification with differential treatment effects serves as an important step towards precision medicine, as it provides evidence regarding how individuals with specific characteristics respond to a given treatment. This knowledge not only supports the tailoring of treatment strategies but also prompts the development of new treatments. This manuscript provides a brief overview of the issues associated with the methodologies aimed at identifying subgroups with differential treatment effects, and studies in depth the operational characteristics of five data-driven methods that have appeared recently in the literature...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28627123/pharmacokinetics-and-relative-bioavailability-of-orally-administered-innovator-formulated-itraconazole-capsules-and-solution-in-healthy-dogs
#16
A E Hasbach, D K Langlois, E J Rosser, M G Papich
BACKGROUND: Itraconazole is commonly used for treatment of systemic and cutaneous mycoses in veterinary medicine. Two formulations, capsule and solution, are used interchangeably in dogs. However, marked differences in bioavailability have been reported in other species. Similar investigations have not been performed in dogs. OBJECTIVE: To determine and compare pharmacokinetics of itraconazole in dogs after oral administration of commercially available capsule and solution formulations intended for use in humans...
June 19, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28626998/large-coverage-black-bright-blood-interleaved-imaging-sequence-labbi-for-3d-dynamic-contrast-enhanced-mri-of-vessel-wall
#17
Haikun Qi, Feng Huang, Zechen Zhou, Peter Koken, Niranjan Balu, Bida Zhang, Chun Yuan, Huijun Chen
PURPOSE: To propose a large coverage black-bright blood interleaved imaging sequence (LaBBI) for 3D dynamic contrast-enhanced MRI (DCE-MRI) of the vessel wall. METHODS: LaBBI consists of a 3D black-blood stack-of-stars golden angle radial acquisition with high spatial resolution for vessel wall imaging and a 2D bright-blood Cartesian acquisition with high temporal resolution for arterial input function estimation. The two acquisitions were performed in an interleaved fashion within a single scan...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28626964/impact-of-prior-distributions-and-central-tendency-measures-on-bayesian-intravoxel-incoherent-motion-model-fitting
#18
Oscar Gustafsson, Mikael Montelius, Göran Starck, Maria Ljungberg
PURPOSE: Bayesian model fitting has been proposed as a robust alternative for intravoxel incoherent motion (IVIM) model-fitting parameter estimation. However, consensus regarding choice of prior distribution and posterior distribution central tendency measure is needed. The aim of this study was to compare the quality of IVIM parameter estimates produced by different prior distributions and central tendency measures, and to gain knowledge about the effect of these choices. METHODS: Three prior distributions (uniform, reciprocal, and lognormal) and two measures of central tendency (mean and mode) found in the literature were studied using simulations and in vivo data from a tumor mouse model...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28626952/multivariate-binary-classification-of-imbalanced-datasets-a-case-study-based-on-high-dimensional-multiplex-autoimmune-assay-data
#19
Laura Schlieker, Anna Telaar, Angelika Lueking, Peter Schulz-Knappe, Carmen Theek, Katja Ickstadt
The classification of a population by a specific trait is a major task in medicine, for example when in a diagnostic setting groups of patients with specific diseases are identified, but also when in predictive medicine a group of patients is classified into specific disease severity classes that might profit from different treatments. When the sizes of those subgroups become small, for example in rare diseases, imbalances between the classes are more the rule than the exception and make statistical classification problematic when the error rate of the minority class is high...
June 19, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28623809/dual-target-screening-of-bioactive-components-from-traditional-chinese-medicines-by-hollow-fiber-based-ligand-fishing-combined-with-liquid-chromatography-mass-spectrometry
#20
Liang Chen, Xin Wang, Youping Liu, Xin Di
A novel strategy was developed for dual-target screening of bioactive components from traditional Chinese medicines (TCMs). This strategy was based on the use of low-cost microporous hollow fibers filled with target enzymes as baits to "fish out" the ligands in TCM extracts, followed by identification of the ligands dissociated from the target-ligand complexes by liquid chromatography-mass spectrometry. Ganjiang Huangqin Huanglian Renshen Decoction (GHHRD), a classical TCM prescription for diabetes treatment, was chosen as a model sample to evaluate the feasibility of the proposed strategy...
June 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
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