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https://www.readbyqxmd.com/read/28777970/identification-of-characteristics-and-frequent-scenarios-of-single-vehicle-rollover-crashes-during-pre-ballistic-phase-part-1-a-descriptive-study
#1
Taewung Kim, Dipan Bose, Jon Foster, Varun Bollapragada, Jeff R Crandall, Mark Clauser, Jason R Kerrigan
This study aimed to identify common patterns of pre-ballistic vehicle kinematics and roadway characteristics of real-world rollover crashes. Rollover crashes that were enrolled in the National Automotive Sampling System-Crashworthiness Data System (NASS-CDS) between the years 2000 and 2010 were analyzed. A descriptive analysis was performed to understand the characteristics of the pre-ballistic phase. Also, a frequency based pattern analysis was performed using a selection of NASS-CDS variables describing the pre-ballistic vehicle kinematics and roadway characteristics to rank common pathways of rollover crashes...
August 1, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28767625/patient-reported-outcomes-and-costs-associated-with-revision-surgery-for-degenerative-cervical-spine-diseases
#2
Elliott J Kim, Silky Chotai, Joseph B Wick, David P Stonko, Ahilan Sivaganesan, Clinton J Devin
STUDY DESIGN: Retrospective review of a prospective database. OBJECTIVE: Determine cost and outcomes of revision cervical spine surgery. SUMMARY OF BACKGROUND DATA: Revision rates for cervical spine surgery are steadily increasing. It is important to counsel patients on expected results following a revision procedure. However, outcomes and cost of these procedures are poorly defined in the literature. METHODS: Patients undergoing revision cervical spine surgery at a single institution were included between October 2010 and January 2016 in a prospective registry database...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28753313/neuroactive-steroids-2-3%C3%AE-hydroxy-3%C3%AE-methyl-21-4-cyano-1h-pyrazol-1-yl-19-nor-5%C3%AE-pregnan-20-one-sage-217-a-clinical-next-generation-neuroactive-steroid-positive-allosteric-modulator-of-the-%C3%AE-aminobutyric-acid-a-receptor
#3
Gabriel Martinez Botella, Francesco G Salituro, Boyd L Harrison, Richard T Beresis, Zhu Bai, Maria-Jesus Blanco, Gabriel M Belfort, Jing Dai, Carlos M Loya, Michael A Ackley, Alison L Althaus, Scott J Grossman, Ethan Hoffmann, James J Doherty, Albert J Robichaud
Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of synaptic and extrasynaptic GABAA receptors. Herein we report new SAR insights in a series of 5α-nor-19- pregnan-20-one analogues bearing substituted pyrazoles and triazoles at C-21, culminating in the discovery of 3α-hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217, 3), a potent GABAA receptor modulator at both synaptic and extrasynaptic receptor subtypes, with excellent oral DMPK properties...
July 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28752517/nitrate-reductases-in-hydrogenobacter-thermophilus-with-evolutionarily-ancient-features-distinctive-localization-and-electron-transfer
#4
Masafumi Kameya, Haruna Kanbe, Yasuo Igarashi, Hiroyuki Arai, Masaharu Ishii
Dissimilatory nitrate reductase (NAR) and assimilatory nitrate reductase (NAS) serve as key enzymes for nitrogen catabolism and anabolism in many organisms. We purified NAR and NAS from H. thermophilus, a hydrogen-oxidizing chemolithoautotroph belonging to the phylogenetically deepest branch in the Bacteria domain. Physiological contribution of these enzymes to nitrate respiration and assimilation was clarified by transcriptomic analysis and gene disruption experiments. These enzymes showed several features unreported in bacteria, such as the periplasmic orientation of NAR anchored with a putative transmembrane subunit and the specific electron transfer from a [4Fe-4S]-type ferredoxin to NAS...
July 27, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28743354/analysis-of-four-serum-biomarkers-in-rheumatoid-arthritis-association-with-extra-articular-manifestations-in-patients-and-arthralgia-in-relatives
#5
Flávia R Nass, Thelma L Skare, Isabela Goeldner, Renato Nisihara, Iara T Messias-Reason, Shirley R R Utiyama
OBJECTIVES: To evaluate the frequency of four serum biomarkers in RA patients and their relatives and identify possible associations with clinical findings of the disease. METHODS: This was a transversal analytical study. Anti-cyclic citrullinated peptide (anti-CCP), anti-mutated citrullinated vimentin (anti-MCV) and IgA-rheumatoid factor (RF) were determined by ELISA and IgM-RF by latex agglutination in 210 RA patients, 198 relatives and 92 healthy controls from Southern Brazil...
July 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28738161/belted-driver-fatalities-time-of-death-and-risk-by-injury-severity
#6
David C Viano, Chantal S Parenteau
PURPOSE: This study is a descriptive study of the fatality risk by injury severity and time of death for lap-shoulder belted drivers without ejection in modern vehicles. It also determined the body region for severe injuries experienced by the belted drivers using the most recent federal crash data. METHODS: 1997-2015 NASS-CDS data was evaluated for fatally-injured lap-shoulder belted drivers without ejection in light vehicles of 1997+ model year (MY). The severity of injuries sustained by the belted drivers was assessed by MAIS and individual injuries by AIS and body region...
July 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28731757/phase-locking-the-spin-precession-in-a-storage-ring
#7
N Hempelmann, V Hejny, J Pretz, E Stephenson, W Augustyniak, Z Bagdasarian, M Bai, L Barion, M Berz, S Chekmenev, G Ciullo, S Dymov, F-J Etzkorn, D Eversmann, M Gaisser, R Gebel, K Grigoryev, D Grzonka, G Guidoboni, T Hanraths, D Heberling, J Hetzel, F Hinder, A Kacharava, V Kamerdzhiev, I Keshelashvili, I Koop, A Kulikov, A Lehrach, P Lenisa, N Lomidze, B Lorentz, P Maanen, G Macharashvili, A Magiera, D Mchedlishvili, S Mey, F Müller, A Nass, N N Nikolaev, A Pesce, D Prasuhn, F Rathmann, M Rosenthal, A Saleev, V Schmidt, Y Semertzidis, V Shmakova, A Silenko, J Slim, H Soltner, A Stahl, R Stassen, H Stockhorst, H Ströher, M Tabidze, G Tagliente, R Talman, P Thörngren Engblom, F Trinkel, Yu Uzikov, Yu Valdau, E Valetov, A Vassiliev, C Weidemann, A Wrońska, P Wüstner, P Zuprański, M Żurek
This Letter reports the successful use of feedback from a spin polarization measurement to the revolution frequency of a 0.97  GeV/c bunched and polarized deuteron beam in the Cooler Synchrotron (COSY) storage ring in order to control both the precession rate (≈121  kHz) and the phase of the horizontal polarization component. Real time synchronization with a radio frequency (rf) solenoid made possible the rotation of the polarization out of the horizontal plane, yielding a demonstration of the feedback method to manipulate the polarization...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28713265/a-comparison-of-reimbursement-recommendations-by-european-hta-agencies-is-there-opportunity-for-further-alignment
#8
Nicola Allen, Lawrence Liberti, Stuart R Walker, Sam Salek
Introduction: In Europe and beyond, the rising costs of healthcare and limited healthcare resources have resulted in the implementation of health technology assessment (HTA) to inform health policy and reimbursement decision-making. European legislation has provided a harmonized route for the regulatory process with the European Medicines Agency, but reimbursement decision-making still remains the responsibility of each country. There is a recognized need to move toward a more objective and collaborative reimbursement environment for new medicines in Europe...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28665925/neonatal-adaptation-following-intrauterine-antidepressant-exposure-assessment-drug-assay-levels-and-infant-development-outcomes
#9
Megan Galbally, Olav Spigset, Andrew R Johnson, Rolland Kohan, Martha Lappas, Andrew J Lewis
BACKGROUND: While a meta-analysis has confirmed the association between antidepressant exposure in utero and subsequent poor neonatal adaptation, few identified studies included drug levels or standardized measures and only two studies followed up children who developed symptoms beyond infancy. STUDY DESIGN: The study draws on the Mercy Pregnancy and Emotional Wellbeing Study and reports on 42 women/infant pairs at delivery. 31 women continued to take antidepressants until delivery and 11 ceased earlier in pregnancy...
June 30, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28657420/driver-and-front-passenger-injury-in-frontal-crashes-update-on-the-effect-of-unbelted-rear-occupants
#10
Chantal S Parenteau, David C Viano
PURPOSE: This is a study of the influence of an unbelted rear occupant on the risk for severe injury to the front-seat occupant ahead of them in frontal crashes. It provides an update to earlier studies. METHODS: 1997-2015 NASS-CDS data was used to investigate the risk for severe injury (MAIS 4+F) to belted drivers and front passengers in frontal crashes by the presence of a belted or unbelted passenger seated directly behind them or without a rear passenger. Frontal crashes were identified with GAD1 = 'F' without rollover (rollover ≤ 0)...
June 28, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28641782/high-prevalence-of-apolipoprotein-b-dyslipoproteinemias-in-non-alcoholic-fatty-liver-disease-the-lifelines-cohort-study
#11
Karlijn J Nass, Eline H van den Berg, Klaas Nico Faber, Tim C M A Schreuder, Hans Blokzijl, Robin P F Dullaart
OBJECTIVE: Cardiovascular disease (CVD) is a major adverse consequence of non-alcoholic fatty liver disease (NAFLD). The association of NAFLD with various apolipoprotein B (apoB) dyslipoproteinemias is unclear. We determined the prevalence of specific apoB dyslipoproteinemias in subjects with suspected NAFLD. METHODS: This study was conducted among 22,865 fasting adults living in the northern part of the Netherlands (Lifelines Cohort Study). Six apoB dyslipoproteinemias were defined using an algorithm derived from apoB, total cholesterol and triglycerides...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28627251/direct-liquid-chromatography-mass-spectrometry-analysis-for-complete-characterization-of-recombinant-adeno-associated-virus-capsid-proteins
#12
Xiaoying Jin, Lin Liu, Shelley Nass, Catherine O'Riordan, Eric Pastor, X Kate Zhang
The requirement for robust analytical methods to characterize adeno-associated virus (AAV) vectors is immediate, as the field advances more AAV gene therapies into the clinic and onto commercialization. AAV capsid proteins (VPs) are critical for viral infectivity and vector potency. Thus, complete characterization of the constituent viral capsid proteins of AAV vectors, including their sequences and post-translational modifications (PTMs), is highly recommended to ensure AAV product quality and consistency...
June 16, 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/28617167/patient-reported-barriers-to-the-prekidney-transplant-evaluation-in-an-at-risk-population-in-the-united-states
#13
Mark B Lockwood, Milda R Saunders, Rachel Nass, Claire L McGivern, Patrick N Cunningham, W James Chon, Michelle A Josephson, Yolanda T Becker, Christopher S Lee
BACKGROUND: Despite our knowledge of barriers to the early stages of the transplant process, we have limited insight into patient-reported barriers to the prekidney transplant medical evaluation in populations largely at-risk for evaluation failure. METHODS: One-hundred consecutive adults were enrolled at an urban, Midwestern transplant center. Demographic, clinical, and quality of life data were collected prior to patients visit with a transplant surgeon/nephrologist (evaluation begins)...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28602953/patterning-and-morphogenesis-of-the-intricate-but-stereotyped-oikoplastic-epidermis-of-the-appendicularian-oikopleura-dioica
#14
Kanae Kishi, Momoko Hayashi, Takeshi A Onuma, Hiroki Nishida
Mechanisms for morphogenetic processes that generate complex patterns in a reproducible manner remain elusive. Live imaging provides a powerful tool to record cell behaviors. The appendicularian, Oikopleura dioica, is a planktonic tunicate that has a rapid developmental speed, small number of cells (less than 3500 cells in a juvenile), and a transparent body. The trunk epidermis, called the oikoplastic epithelium (OE), has elaborate cellular arrangements showing a complex pattern to secrete so-called "house" made of extracellular components...
August 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28587159/effects-of-low-dose-non-caloric-sweetener-consumption-on-gut-microbiota-in-mice
#15
Takashi Uebanso, Ai Ohnishi, Reiko Kitayama, Ayumi Yoshimoto, Mutsumi Nakahashi, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi
Abstract: Non-caloric artificial sweeteners (NASs) provide sweet tastes to food without adding calories or glucose. NASs can be used as alternative sweeteners for controlling blood glucose levels and weight gain. Although the consumption of NASs has increased over the past decade in Japan and other countries, whether these sweeteners affect the composition of the gut microbiome is unclear. In the present study, we examined the effects of sucralose or acesulfame-K ingestion (at most the maximum acceptable daily intake (ADI) levels, 15 mg/kg body weight) on the gut microbiome in mice...
June 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28586255/disparities-in-assisted-reproductive-technology-utilization-by-race-and-ethnicity-united-states-2014-a-commentary
#16
Ada C Dieke, Yujia Zhang, Dmitry M Kissin, Wanda D Barfield, Sheree L Boulet
Disparities in infertility and access to infertility treatments, such as assisted reproductive technology (ART), by race/ethnicity, have been reported. However, identifying disparities in ART usage may have been hampered by missing race/ethnicity information in ART surveillance. We review infertility prevalence and treatment disparities, use recent data to examine ART use in the United States by race/ethnicity and residency in states with mandated insurance coverage for in vitro fertilization (IVF), and discuss approaches for reducing disparities...
June 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28540450/high-neuronatin-nnat-expression-is-associated-with-poor-outcome-in-breast-cancer
#17
Norbert Nass, Sarah Walter, Dörthe Jechorek, Christine Weissenborn, Atanas Ignatov, Johannes Haybaeck, Saadettin Sel, Thomas Kalinski
Neuronatin (NNAT) is a proteolipid involved in cation homeostasis especially in the developing brain. Its expression has been associated with the progression of lung cancer, glioblastoma, and neuroblastoma as well as glucose induced apoptosis in pancreatic cells. We performed a retrospective study of 148 breast cancer specimens for NNAT expression by immunohistochemistry to evaluate this protein as a prognostic marker for breast cancer. We found a high NNAT immunoreactivity score (by multivariate cox regression) to be an independent prognostic marker for relapse-free (hazard ratio HR = 3...
May 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28535324/juanita-perfecta
#18
Scott Edward Nass
No abstract text is available yet for this article.
May 2017: Family Medicine
https://www.readbyqxmd.com/read/28474433/regulation-of-nitrous-oxide-reductase-genes-by-nast-mediated-transcription-antitermination-in-bradyrhizobium-diazoefficiens
#19
Cristina Sánchez, Hisayuki Mitsui, Kiwamu Minamisawa
In Bradyrhizobium diazoefficiens, maximal expression of the nitrous oxide reductase gene (nosZ) requires oxygen limitation and the presence of a nitrogen oxide. The putative transcription antiterminator NasT is a positive regulator of nosZ; but in the absence of nitrate, NasT is counteracted by the nitrate sensor NasS. Here, we examined the NasT-mediated mechanism of nosRZDFYLX gene cluster expression. We mapped two transcription start sites of nosR and identified two potential hairpins, H1 and H2, within the 5'-leader of nosR transcripts...
May 4, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28455751/national-trends-and-outcomes-of-autologous-in-vitro-fertilization-cycles-among-women-ages-40-years-and-older
#20
Heather Hipp, Sara Crawford, Jennifer F Kawwass, Sheree L Boulet, David A Grainger, Dmitry M Kissin, Denise Jamieson
PURPOSE: The purpose of the study was to describe trends in and investigate variables associated with clinical pregnancy and live birth in autologous in vitro fertilization (IVF) cycles among women ≥40 years. METHODS: We used autologous IVF cycle data from the National ART Surveillance System (NASS) for women ≥40 years at cycle start. We assessed trends in fresh and frozen cycles (n = 371,536) from 1996 to 2013. We reported perinatal outcomes and determined variables associated with clinical pregnancy and live birth in fresh cycles between 2007 and 2013...
July 2017: Journal of Assisted Reproduction and Genetics
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