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https://www.readbyqxmd.com/read/27932338/meaning-of-living-with-severe-chronic-obstructive-lung-disease-a-qualitative-study
#1
Gabriella Marx, Maximilian Nasse, Henrikje Stanze, Sonja Owusu Boakye, Friedemann Nauck, Nils Schneider
OBJECTIVES: To explore what it means for patients to live with chronic obstructive pulmonary disease (COPD) as an incurable and constantly progressing disease. DESIGN: Qualitative longitudinal study using narrative and semistructured interviews. This paper presents findings of the initial interviews. Analysis using grounded theory. SETTING: Lung care clinics and community care in Lower Saxony, Germany. PARTICIPANTS: 17 patients with advanced-stage COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) III/IV)...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27872345/hazards-of-cigarettes-smokeless-tobacco-and-waterpipe-in-a-middle-eastern-population-a-cohort-study-of-50%C3%A2-000-individuals-from-iran
#2
Arash Etemadi, Hooman Khademi, Farin Kamangar, Neal D Freedman, Christian C Abnet, Paul Brennan, Reza Malekzadeh
BACKGROUND: There is limited information about the hazards of cigarettes, smokeless tobacco and waterpipe in the Middle East. The aim of this study was to determine the association between different types of tobacco use and earlier death in the Golestan Cohort Study. METHODS: The Study includes 50 045 adults (aged 40-75 years) from north eastern Iran. The baseline questionnaire (2004-2008) assessed information about use of cigarettes, chewing tobacco (nass) and waterpipe...
November 21, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27871102/new-risk-curves-for-nhtsa-s-brain-injury-criterion-bric-derivations-and-assessments
#3
Tony R Laituri, Scott Henry, Kevin Pline, Guosong Li, Michael Frankstein, Para Weerappuli
The National Highway Traffic Safety Administration (NHTSA) recently published a Request for Comments regarding a potential upgrade to the US New Car Assessment Program (US NCAP) - a star-rating program pertaining to vehicle crashworthiness. Therein, NHTSA (a) cited two metrics for assessing head risk: Head Injury Criterion (HIC15) and Brain Injury Criterion (BrIC), and (b) proposed to conduct risk assessment via its risk curves for those metrics, but did not prescribe a specific method for applying them. Recent studies, however, have indicated that the NHTSA risk curves for BrIC significantly overstate field-based head injury rates...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27871101/morphomics-of-the-talus
#4
David Gorman, Ebram Handy, Sikui Wang, Annette L Irwin, Stewart Wang
Previous studies of frontal crash databases reported that ankle fractures are among the most common lower extremity fractures. While not generally life threatening, these injuries can be debilitating. Laboratory research into the mechanisms of ankle fractures has linked dorsiflexion with an increased risk of tibia and fibula malleolus fractures. However, talus fractures were not produced in the laboratory tests and appear to be caused by more complex loading of the joint. In this study, an analysis of the National Automotive Sampling System - Crashworthiness Data System (NASS-CDS) for the years 2004-2013 was conducted to investigate foot-ankle injury rates in front seat occupants involved in frontal impact crashes...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27871091/age-specific-injury-risk-curves-for-distributed-anterior-thoracic-loading-of-various-sizes-of-adults-based-on-sternal-deflections
#5
Harold J Mertz, Priya Prasad, Dainius J Dalmotas, Annette L Irwin
Injury Risk Curves are developed from cadaver data for sternal deflections produced by anterior, distributed chest loads for a 25, 45, 55, 65 and 75 year-old Small Female, Mid-Size Male and Large Male based on the variations of bone strengths with age. These curves show that the risk of AIS ≥ 3 thoracic injury increases with the age of the person. This observation is consistent with NASS data of frontal accidents which shows that older unbelted drivers have a higher risk of AIS ≥ 3 chest injury than younger drivers...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27846241/sprint-start-kinetics-of-amputee-and-non-amputee-sprinters
#6
Steffen Willwacher, Volker Herrmann, Kai Heinrich, Johannes Funken, Gerda Strutzenberger, Jan-Peter Goldmann, Björn Braunstein, Adam Brazil, Gareth Irwin, Wolfgang Potthast, Gert-Peter Brüggemann
The purpose of this study was to explore the relationship between the forces applied to the starting blocks and the start performances (SPs) of amputee sprinters (ASs) and non-amputee sprinters (NASs). SPs of 154 male and female NASs (100-m personal records [PRs], 9.58-14.00 s) and 7 male ASs (3 unilateral above knee, 3 unilateral below knee, 1 bilateral below knee; 100 m PRs, 11.70-12.70 s) with running specific prostheses (RSPs) were analysed during full-effort sprint starts using instrumented starting blocks that measured the applied forces in 3D...
2016: PloS One
https://www.readbyqxmd.com/read/27824451/frequency-comb-spectrum-of-periodic-patterned-signals
#7
Johannes L Steinmann, Edmund Blomley, Miriam Brosi, Erik Bründermann, Michele Caselle, Jeffrey L Hesler, Nicole Hiller, Benjamin Kehrer, Yves-Laurent Mathis, Michael J Nasse, Juliane Raasch, Manuel Schedler, Patrik Schönfeldt, Marcel Schuh, Markus Schwarz, Michael Siegel, Nigel Smale, Marc Weber, Anke-Susanne Müller
Using arbitrary periodic pulse patterns we show the enhancement of specific frequencies in a frequency comb. The envelope of a regular frequency comb originates from equally spaced, identical pulses and mimics the single pulse spectrum. We investigated spectra originating from the periodic emission of pulse trains with gaps and individual pulse heights, which are commonly observed, for example, at high-repetition-rate free electron lasers, high power lasers, and synchrotrons. The ANKA synchrotron light source was filled with defined patterns of short electron bunches generating coherent synchrotron radiation in the terahertz range...
October 21, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27747559/side-impact-motor-vehicle-crashes-driver-passenger-vehicle-and-crash-characteristics-for-fatally-and-nonfatally-injured-rear-seated-adults
#8
Chang Liu, Joyce C Pressley
BACKGROUND: Most studies of rear-seated occupants have focused on or included pediatric occupants which may not translate to adults. This study examines passenger, driver, vehicle and crash characteristics for rear-seated adult occupants involved in side crashes. METHODS: The National Automotive Sampling System General Estimates System (NASS/GES) for calendar years 2011-2014 was used with accompanying weights to examine the occupant, vehicle and crash characteristics associated with injury in rear-seated adults (n = 395,504) involved in a side crash...
December 2016: Injury Epidemiology
https://www.readbyqxmd.com/read/27743930/endogenous-and-synthetic-neuroactive-steroids-evoke-sustained-increases-in-the-efficacy-of-gabaergic-inhibition-via-a-protein-kinase%C3%A2-c-dependent-mechanism
#9
Amit Modgil, Manasa L Parakala, Michael A Ackley, James J Doherty, Stephen J Moss, Paul A Davies
The neuroactive steroid (NAS) tetrahydrodeoxycorticosterone (THDOC) increases protein kinase C (PKC) mediated phosphorylation of extrasynaptic GABAA receptor (GABAAR) subunits leading to increased surface expression of α4/β3 subunit-containing extrasynaptic GABAARs, leading to a sustained increase in GABAAR tonic current density. Whether other naturally occurring and synthetic NASs share both an allosteric and metabotropic action on GABAARs is unknown. Here, we examine the allosteric and metabotropic properties of allopregnanolone (ALLO), and synthetic NASs SGE-516 and ganaxolone...
February 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27617768/comparison-of-the-efficiency-of-rose-bengal-and-methylene-blue-as-photosensitizers-in-photodynamic-therapy-techniques-for-enterococcus-faecalis-inactivation
#10
Catia Cilene Nass Sebrão, Arandi Ginane Bezerra Junior, Paulo Henrique Condeixa de França, Leslie Ecker Ferreira, Vania Portela Ditzel Westphalen
The aim of this in vitro study was to compare the efficiency of a photodynamic therapy (PDT) technique employing rose bengal (RB) and methylene blue (MB) as photosensitizers (PSs) to reduce the viability of Enterococcus faecalis, a well-known pathogen found in root canal systems. Currently, in several clinical applications, including in the field of endodontics, MB is employed in association with a red laser source for the photoinactivation of pathogenic bacteria. Here, it was used at 0.01% (31.2 mol/L) in association with a red (660 nm) laser as the excitation source in the MB group (MBG)...
September 9, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27592807/guideline-summary-review-an-evidence-based-clinical-guideline-for-the-diagnosis-and-treatment-of-adult-isthmic-spondylolisthesis
#11
REVIEW
D Scott Kreiner, Jamie Baisden, Daniel J Mazanec, Rakesh D Patel, Robert S Bess, Douglas Burton, Norman B Chutkan, Bernard A Cohen, Charles H Crawford, Gary Ghiselli, Amgad S Hanna, Steven W Hwang, Cumhur Kilincer, Mark E Myers, Paul Park, Karie A Rosolowski, Anil K Sharma, Christopher K Taleghani, Terry R Trammell, Andrew N Vo, Keith D Williams
BACKGROUND CONTEXT: The North American Spine Society's (NASS) Evidence-Based Clinical Guideline for the Diagnosis and Treatment of Adult Isthmic Spondylolisthesis features evidence-based recommendations for diagnosing and treating adult patients with isthmic spondylolisthesis. The guideline is intended to reflect contemporary treatment concepts for symptomatic isthmic spondylolisthesis as reflected in the highest quality clinical literature available on this subject as of June 2013. NASS' guideline on this topic is the only guideline on adult isthmic spondylolisthesis accepted in the Agency for Healthcare Research and Quality's National Guideline Clearinghouse...
September 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27591770/navigation-improves-the-learning-curve-of-transforamimal-percutaneous-endoscopic-lumbar-discectomy
#12
Guoxin Fan, Ruoshuang Han, Xin Gu, Hailong Zhang, Xiaofei Guan, Yunshan Fan, Teng Wang, Shisheng He
PURPOSE: Beginners usually need increased punctures and dozens of fluoroscopy in learning transforamimal percutaneous endoscopic lumbar discectomy (tPELD). Navigator-assisted spinal surgery (NASS) is a novel technique that could induce a definite trajectory. The retrospective study aimed to investigate the impact of a definite trajectory on the learning curve of tPELD. METHODS: A total of 120 patients with symptomatic lumbar disc herniation who received tPELD between 2012 and 2014...
September 3, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27586116/on-equal-footing-trends-in-ankle-foot-injuries-for-men-vs-women
#13
Patricia C Dischinger, Joseph A Kufera, Shiu M Ho, Gabriel E Ryb, Stewart Wang
OBJECTIVES: The objective of the current study was to examine trends in ankle/foot (A/F) injuries during the period 2001-2014, in order to determine whether the incidence of these injuries has changed and whether a previously identified difference in risk by gender still existed. In addition, other driver and crash-related risk factors were examined separately for men and women. METHODS: Passenger vehicle drivers aged 16+ were identified from NASS-CDS; weighted data were analyzed for model years 2001-2014...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27586111/lumbar-vertebrae-fracture-injury-risk-in-finite-element-reconstruction-of-ciren-and-nass-frontal-motor-vehicle-crashes
#14
Derek A Jones, James P Gaewsky, Mireille E Kelley, Ashley A Weaver, Anna N Miller, Joel D Stitzel
INTRODUCTION: The objective of this study was to reconstruct 4 real-world motor vehicle crashes (MVCs), 2 with lumbar vertebral fractures and 2 without vertebral fractures in order to elucidate the MVC and/or restraint variables that increase this injury risk. METHODS: A finite element (FE) simplified vehicle model (SVM) was used in conjunction with a previously developed semi-automated tuning method to arrive at 4 SVMs that were tuned to mimic frontal crash responses of a 2006 Chevrolet Cobalt, 2012 Ford Escape, 2007 Hummer H3, and 2002 Chevrolet Cavalier...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27586099/functional-outcomes-of-motor-vehicle-crash-head-injuries-in-pediatric-and-adult-occupants
#15
Samantha L Schoell, Ashley A Weaver, Jennifer W Talton, Gretchen Baker, Andrea N Doud, Ryan T Barnard, Joel D Stitzel, Mark R Zonfrillo
OBJECTIVE: The objective of the study was to develop a disability-based metric for motor vehicle crash (MVC) injuries, with a focus on head injuries, and compare the functional outcomes between the pediatric and adult populations. METHODS: Disability risk (DR) was quantified using Functional Independence Measure (FIM) scores within the National Trauma Data Bank-Research Data System (NTDB-RDS) for the top 95% most frequently occurring Abbreviated Injury Scale (AIS) 3, 4, and 5 head injuries in NASS-CDS 2000-2011...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27528673/scavenging-nucleic-acid-debris-to-combat-autoimmunity-and-infectious-disease
#16
Eda K Holl, Kara L Shumansky, Luke B Borst, Angela D Burnette, Christopher J Sample, Elizabeth A Ramsburg, Bruce A Sullenger
Nucleic acid-containing debris released from dead and dying cells can be recognized as damage-associated molecular patterns (DAMPs) or pattern-associated molecular patterns (PAMPs) by the innate immune system. Inappropriate activation of the innate immune response can engender pathological inflammation and autoimmune disease. To combat such diseases, major efforts have been made to therapeutically target the pattern recognition receptors (PRRs) such as the Toll-like receptors (TLRs) that recognize such DAMPs and PAMPs, or the downstream effector molecules they engender, to limit inflammation...
August 30, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27517774/how-to-reach-a-thousand-second-in-plane-polarization-lifetime-with-0-97-gev-c-deuterons-in-a-storage-ring
#17
G Guidoboni, E Stephenson, S Andrianov, W Augustyniak, Z Bagdasarian, M Bai, M Baylac, W Bernreuther, S Bertelli, M Berz, J Böker, C Böhme, J Bsaisou, S Chekmenev, D Chiladze, G Ciullo, M Contalbrigo, J-M de Conto, S Dymov, R Engels, F M Esser, D Eversmann, O Felden, M Gaisser, R Gebel, H Glückler, F Goldenbaum, K Grigoryev, D Grzonka, T Hahnraths, D Heberling, V Hejny, N Hempelmann, J Hetzel, F Hinder, R Hipple, D Hölscher, A Ivanov, A Kacharava, V Kamerdzhiev, B Kamys, I Keshelashvili, A Khoukaz, I Koop, H-J Krause, S Krewald, A Kulikov, A Lehrach, P Lenisa, N Lomidze, B Lorentz, P Maanen, G Macharashvili, A Magiera, R Maier, K Makino, B Mariański, D Mchedlishvili, Ulf-G Meißner, S Mey, W Morse, F Müller, A Nass, G Natour, N Nikolaev, M Nioradze, K Nowakowski, Y Orlov, A Pesce, D Prasuhn, J Pretz, F Rathmann, J Ritman, M Rosenthal, Z Rudy, A Saleev, T Sefzick, Y Semertzidis, Y Senichev, V Shmakova, A Silenko, M Simon, J Slim, H Soltner, A Stahl, R Stassen, M Statera, H Stockhorst, H Straatmann, H Ströher, M Tabidze, R Talman, P Thörngren Engblom, F Trinkel, A Trzciński, Yu Uzikov, Yu Valdau, E Valetov, A Vassiliev, C Weidemann, C Wilkin, A Wrońska, P Wüstner, M Zakrzewska, P Zuprański, D Zyuzin
We observe a deuteron beam polarization lifetime near 1000 s in the horizontal plane of a magnetic storage ring (COSY). This long spin coherence time is maintained through a combination of beam bunching, electron cooling, sextupole field corrections, and the suppression of collective effects through beam current limits. This record lifetime is required for a storage ring search for an intrinsic electric dipole moment on the deuteron at a statistical sensitivity level approaching 10^{-29}  e cm.
July 29, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27393912/development-and-validation-of-a-generic-finite-element-vehicle-buck-model-for-the-analysis-of-driver-rib-fractures-in-real-life-nearside-oblique-frontal-crashes
#18
Johan Iraeus, Mats Lindquist
OBJECTIVE: Frontal crashes still account for approximately half of all fatalities in passenger cars, despite several decades of crash-related research. For serious injuries in this crash mode, several authors have listed the thorax as the most important. Computer simulation provides an effective tool to study crashes and evaluate injury mechanisms, and using stochastic input data, whole populations of crashes can be studied. The aim of this study was to develop a generic buck model and to validate this model on a population of real-life frontal crashes in terms of the risk of rib fracture...
October 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27393270/embryo-donation-national-trends-and-outcomes-2000-through-2013
#19
Jennifer F Kawwass, Sara Crawford, Heather S Hipp, Sheree L Boulet, Dmitry M Kissin, Denise J Jamieson
BACKGROUND: Limited published data exist detailing outcomes of donor embryo cycles. Patients and clinicians would benefit from information specific to donor embryo cycles to inform fertility treatment options, counselling, and clinical decision-making. OBJECTIVE: We sought to quantify trends in donor embryo cycles in the United States, to characterize donor embryo recipients, and to report transfer, pregnancy, and birth outcomes of donor embryo transfers. STUDY DESIGN: This retrospective cohort study of frozen donor embryo transfers uses data from Centers for Disease Control and Prevention National ART Surveillance System to quantify trends in the use of donor embryos and corresponding rates of pregnancy and live birth from 2000 through 2013...
December 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27390321/early-biomarkers-from-conventional-and-delayed-contrast-mri-to-predict-the-response-to-bevacizumab-in-recurrent-high-grade-gliomas
#20
D Daniels, D Guez, D Last, C Hoffmann, D Nass, A Talianski, G Tsarfaty, S Salomon, A A Kanner, D T Blumenthal, F Bokstein, S Harnof, D Yekutieli, S Zamir, Z R Cohen, L Zach, Y Mardor
BACKGROUND AND PURPOSE: The interpretation of the radiologic response of bevacizumab-treated patients with recurrent high-grade gliomas represents a unique challenge. Delayed-contrast MR imaging was recently introduced for calculating treatment-response-assessment maps in patients with brain tumors, providing clear separation between active tumor and treatment effects. We studied the application of standard and delayed-contrast MR imaging for assessing and predicting the response to bevacizumab...
July 7, 2016: AJNR. American Journal of Neuroradiology
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