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https://www.readbyqxmd.com/read/28627251/direct-lc-ms-analysis-for-complete-characterization-of-recombinant-adeno-associated-virus-capsid-proteins
#1
Xiaoying Jin, Lin Liu, Shelley Nass, Catherine R O'Riordan, Eric Pastor, Kate Xiaokui Zhang
The requirement for robust analytical methods to support characterization of Adeno-Associated Virus (AAV) vectors is immediate, as the field advances more AAV gene therapeutics into the clinic and onto commercialization. AAV capsid proteins (VPs) are critical for viral infectivity and vector potency, thus, complete characterization of the constituent viral capsid proteins of AAV vector therapeutics, including their sequence and post-translational modifications (PTMs), is highly recommended to ensure AAV product quality and consistency...
June 18, 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/28617167/patient-reported-barriers-to-the-prekidney-transplant-evaluation-in-an-at-risk-population-in-the-united-states
#2
Mark B Lockwood, Milda R Saunders, Rachel Nass, Claire L McGivern, Patrick N Cunningham, W James Chon, Michelle A Josephson, Yolanda T Becker, Christopher S Lee
BACKGROUND: Despite our knowledge of barriers to the early stages of the transplant process, we have limited insight into patient-reported barriers to the prekidney transplant medical evaluation in populations largely at-risk for evaluation failure. METHODS: One-hundred consecutive adults were enrolled at an urban, Midwestern transplant center. Demographic, clinical, and quality of life data were collected prior to patients visit with a transplant surgeon/nephrologist (evaluation begins)...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28602953/patterning-and-morphogenesis-of-the-intricate-but-stereotyped-oikoplastic-epidermis-of-the-appendicularian-oikopleura-dioica
#3
Kanae Kishi, Momoko Hayashi, Takeshi A Onuma, Hiroki Nishida
Mechanisms for morphogenetic processes that generate complex patterns in a reproducible manner remain elusive. Live imaging provides a powerful tool to record cell behaviors. The appendicularian, Oikopleura dioica, is a planktonic tunicate that has a rapid developmental speed, small number of cells (less than 3500 cells in a juvenile), and a transparent body. The trunk epidermis, called the oikoplastic epithelium (OE), has elaborate cellular arrangements showing a complex pattern to secrete so-called "house" made of extracellular components...
June 8, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28587159/effects-of-low-dose-non-caloric-sweetener-consumption-on-gut-microbiota-in-mice
#4
Takashi Uebanso, Ai Ohnishi, Reiko Kitayama, Ayumi Yoshimoto, Mutsumi Nakahashi, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi
Abstract: Non-caloric artificial sweeteners (NASs) provide sweet tastes to food without adding calories or glucose. NASs can be used as alternative sweeteners for controlling blood glucose levels and weight gain. Although the consumption of NASs has increased over the past decade in Japan and other countries, whether these sweeteners affect the composition of the gut microbiome is unclear. In the present study, we examined the effects of sucralose or acesulfame-K ingestion (at most the maximum acceptable daily intake (ADI) levels, 15 mg/kg body weight) on the gut microbiome in mice...
June 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28586255/disparities-in-assisted-reproductive-technology-utilization-by-race-and-ethnicity-united-states-2014-a-commentary
#5
Ada C Dieke, Yujia Zhang, Dmitry M Kissin, Wanda D Barfield, Sheree L Boulet
Disparities in infertility and access to infertility treatments, such as assisted reproductive technology (ART), by race/ethnicity, have been reported. However, identifying disparities in ART usage may have been hampered by missing race/ethnicity information in ART surveillance. We review infertility prevalence and treatment disparities, use recent data to examine ART use in the United States by race/ethnicity and residency in states with mandated insurance coverage for in vitro fertilization (IVF), and discuss approaches for reducing disparities...
June 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28540450/high-neuronatin-nnat-expression-is-associated-with-poor-outcome-in-breast-cancer
#6
Norbert Nass, Sarah Walter, Dörthe Jechorek, Christine Weissenborn, Atanas Ignatov, Johannes Haybaeck, Saadettin Sel, Thomas Kalinski
Neuronatin (NNAT) is a proteolipid involved in cation homeostasis especially in the developing brain. Its expression has been associated with the progression of lung cancer, glioblastoma, and neuroblastoma as well as glucose induced apoptosis in pancreatic cells. We performed a retrospective study of 148 breast cancer specimens for NNAT expression by immunohistochemistry to evaluate this protein as a prognostic marker for breast cancer. We found a high NNAT immunoreactivity score (by multivariate cox regression) to be an independent prognostic marker for relapse-free (hazard ratio HR = 3...
May 24, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28535324/juanita-perfecta
#7
Scott Edward Nass
No abstract text is available yet for this article.
May 2017: Family Medicine
https://www.readbyqxmd.com/read/28474433/regulation-of-nitrous-oxide-reductase-genes-by-nast-mediated-transcription-antitermination-in-bradyrhizobium-diazoefficiens
#8
Cristina Sánchez, Hisayuki Mitsui, Kiwamu Minamisawa
In Bradyrhizobium diazoefficiens, maximal expression of the nitrous oxide reductase gene (nosZ) requires oxygen limitation and the presence of a nitrogen oxide. The putative transcription antiterminator NasT is a positive regulator of nosZ; but in the absence of nitrate, NasT is counteracted by the nitrate sensor NasS. Here we examined the NasT-mediated mechanism of nosRZDFYLX gene cluster expression. We mapped two transcription start sites of nosR and identified two potential hairpins, H1 and H2, within the 5'-leader of nosR transcripts...
May 4, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28455751/national-trends-and-outcomes-of-autologous-in-vitro-fertilization-cycles-among-women-ages-40-years-and-older
#9
Heather Hipp, Sara Crawford, Jennifer F Kawwass, Sheree L Boulet, David A Grainger, Dmitry M Kissin, Denise Jamieson
PURPOSE: The purpose of the study was to describe trends in and investigate variables associated with clinical pregnancy and live birth in autologous in vitro fertilization (IVF) cycles among women ≥40 years. METHODS: We used autologous IVF cycle data from the National ART Surveillance System (NASS) for women ≥40 years at cycle start. We assessed trends in fresh and frozen cycles (n = 371,536) from 1996 to 2013. We reported perinatal outcomes and determined variables associated with clinical pregnancy and live birth in fresh cycles between 2007 and 2013...
April 28, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28436738/brainstem-injury-in-motor-vehicle-crashes
#10
David C Viano, Chantal S Parenteau
OBJECTIVE: This is a descriptive study of the frequency and risk for brainstem injury by crash type, belt use, and crash severity (delta-V). NASS-CDS electronic cases were reviewed to see whether the transition from vehicles without advanced airbags and seat belts and side airbags and curtains to vehicles with the safety technologies has influenced the risk for brainstem injury. METHODS: 1994-2013 NASS-CDS was analyzed to determine the number of brainstem injuries in nonejected adults (15+ years old) in vehicle crashes...
March 1, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28436001/gait-instability-in-valproate-treated-patients-call-to-measure-ammonia-levels
#11
S Kipervasser, C E Elger, A D Korczyn, R D Nass, C M Quesada, M Y Neufeld
OBJECTIVE: Hyperammonemia induced by valproate (VPA) treatment may lead to several neurological and systemic symptoms as well as to seizure exacerbation. Gait instability and recurrent falls are rarely mentioned as symptoms, especially not as predominant ones. METHODS: We report five adult patients with frontal lobe epilepsy (FLE) who were treated with VPA and in whom a primary adverse effect was unstable gait and falls. RESULTS: There were four males and one female patients with FLE, 25-42-year-old, three following epilepsy surgery...
April 23, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28422799/publication-rates-of-abstracts-accepted-to-the-2010-2012-annual-meetings-of-the-north-american-spine-society
#12
Ankur S Narain, Fady Y Hijji, Krishna T Kudaravalli, Kelly H Yom, Kern Singh
STUDY DESIGN: Retrospective review of conference abstracts. OBJECTIVE: To determine the publication rate of podium and poster presentations at the 2010-2012 North American Spine Society (NASS) annual meetings. SUMMARY OF BACKGROUND DATA: Presentations at medical conferences are utilized to disseminate new clinical information. The orthopaedic literature estimates the rate of publication for abstracts presented at major meetings to be between 34...
April 18, 2017: Spine
https://www.readbyqxmd.com/read/28419861/agroecological-and-environmental-factors-influence-barley-yellow-dwarf-viruses-in-grasslands-in-the-us-pacific-northwest
#13
Laura L Ingwell, Christelle Lacroix, Paul R Rhoades, Alexander V Karasev, Nilsa A Bosque-Pérez
Plant pathogens can play a role in the competitive interactions between plant species and have been understudied in native prairies, which are declining globally, and in Conservation Reserve Program (CRP) lands in the United States. Barley/Cereal yellow dwarf virus (B/CYDV) are among the most economically important disease-causing agents of small grain cereal crops, such as wheat, and are known to infect over 150 Poaceae species, including many of the grass species present in prairies and CRP lands. Field surveys of Poaceae species were conducted in endangered Palouse Prairie and CRP habitats of southeastern Washington and adjacent northern Idaho, USA from 2010-2012 to examine for the presence of B/CYDV among plant hosts and aphid vectors...
April 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28407596/super-enhanced-particle-nucleation-in-styrene-emulsion-polymerization-in-the-presence-of-sodium-styrene-sulfonate
#14
Lorena Farias-Cepeda, Jorge Herrera-Ordonez, Angel R Hernandez-Martinez, Miriam Estevez, Lucero Rosales-Marines
The styrene (St) emulsion polymerization using Aerosol MA80 as surfactant and in the presence of sodium styrene sulfonate (NaSS) was studied. The effect of NaSS content was assessed using MA80 concentrations below and at the critical micellar concentration. It was found that at the higher NaSS and MA80 contents, the number of particles (N) reaches a maximum of the order of 10(17)particles/cm(3) water, a huge value that has never been reported. In this work an explanation for this super-enhanced particle nucleation phenomenon is proposed...
April 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28406687/investigating-the-relationship-between-media-multitasking-and-processes-involved-in-task-switching
#15
Reem Alzahabi, Mark W Becker, David Z Hambrick
Although multitasking with media has increased dramatically in recent years (Rideout, Foehr, & Roberts, 2010), the association between media multitasking and cognitive performance is poorly understood. In addition, the literature on the relationship between media multitasking and task-switching, one measure of cognitive control, has produced mixed results (Alzahabi & Becker, 2013; Minear et al., 2013; Ophir, Nass, & Wagner, 2009). Here we use an individual differences approach to investigate the relationship between media multitasking and task-switching performance by first examining the structure of task-switching and identifying the latent factors that contribute to switch costs...
April 13, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28390480/a-simple-and-rapid-method-for-isotopic-analysis-of-nickel-copper-and-zinc-in-seawater-using-chelating-extraction-and-anion-exchange
#16
Shotaro Takano, Masaharu Tanimizu, Takafumi Hirata, Ki-Cheol Shin, Yusuke Fukami, Katsuhiko Suzuki, Yoshiki Sohrin
Stable isotope ratios of nickel, copper, and zinc are powerful tools for elucidating the biogeochemical cycling of trace metals in the ocean. However, analytical difficulties have impeded isotopic studies of these metals. We present a simple and rapid method for simultaneous analysis of Ni, Cu, and Zn isotope ratios in seawater using NOBIAS Chelate-PA1 resin and anion exchange resin. A NOBIAS Chelate-PA1 resin column was used to quantitatively collect Ni, Cu, and Zn from seawater and thoroughly remove the seawater matrix...
May 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28385879/transcriptional-and-translational-adaptation-to-aerobic-nitrate-anabolism-in-the-denitrifier-paracoccus-denitrificans
#17
Victor M Luque-Almagro, Isabel Manso, Matthew J Sullivan, Gary Rowley, Stuart J Ferguson, Conrado Moreno-Vivián, David J Richardson, Andrew J Gates, M Dolores Roldán
Transcriptional adaptation to nitrate-dependent anabolism by Paracoccus denitrificans PD1222 was studied. A total of 74 genes were induced in cells grown with nitrate as N-source compared with ammonium, including nasTSABGHC and ntrBC genes. The nasT and nasS genes were cotranscribed, although nasT was more strongly induced by nitrate than nasS The nasABGHC genes constituted a transcriptional unit, which is preceded by a non-coding region containing hairpin structures involved in transcription termination. The nasTS and nasABGHC transcripts were detected at similar levels with nitrate or glutamate as N-source, but nasABGHC transcript was undetectable in ammonium-grown cells...
May 10, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28384071/estimate-of-mortality-reduction-with-implementation-of-advanced-automatic-collision-notification
#18
Ellen Lee, Jingshu Wu, Thomas Kang, Matthew Craig
OBJECTIVE: Advanced Automatic Collision Notification (AACN) is a system on a motor vehicle that notifies a public safety answering point (PSAP), either directly or through a third party, that the vehicle has had a crash. AACN systems enable earlier notification of a motor vehicle crash and provide an injury prediction that can help dispatchers and first responders make better decisions about how and where to transport the patient, thus getting the patient to definitive care sooner. The purposes of the current research are to identify the target population that could benefit from AACN, and to develop a reasonable estimate range of potential lives saved with implementation of AACN within the vehicle fleet...
May 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28364549/deleterious-variants-in-trak1-disrupt-mitochondrial-movement-and-cause-fatal-encephalopathy
#19
Ortal Barel, May Christine V Malicdan, Bruria Ben-Zeev, Judith Kandel, Hadass Pri-Chen, Joshi Stephen, Inês G Castro, Jeremy Metz, Osama Atawa, Sharon Moshkovitz, Eti Ganelin, Iris Barshack, Sylvie Polak-Charcon, Dvora Nass, Dina Marek-Yagel, Ninette Amariglio, Nechama Shalva, Thierry Vilboux, Carlos Ferreira, Ben Pode-Shakked, Gali Heimer, Chen Hoffmann, Tal Yardeni, Andreea Nissenkorn, Camila Avivi, Eran Eyal, Nitzan Kol, Efrat Glick Saar, Douglas C Wallace, William A Gahl, Gideon Rechavi, Michael Schrader, David M Eckmann, Yair Anikster
Cellular distribution and dynamics of mitochondria are regulated by several motor proteins and a microtubule network. In neurons, mitochondrial trafficking is crucial because of high energy needs and calcium ion buffering along axons to synapses during neurotransmission. The trafficking kinesin proteins (TRAKs) are well characterized for their role in lysosomal and mitochondrial trafficking in cells, especially neurons. Using whole exome sequencing, we identified homozygous truncating variants in TRAK1 (NM_001042646:c...
March 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28363171/severe-soft-tissue-injuries-of-the-upper-extremity-in-motor-vehicle-crashes-involving-partial-ejection-the-protective-role-of-side-curtain-airbags
#20
Robert Kaufman, Laura Fraade-Blanar, Angelo Lipira, Jeffrey Friedrich, Eileen Bulger
INTRODUCTION: Partial ejection (PE) of the upper extremity (UE) can occur in a motor vehicle crash (MVC) resulting in complex and severe soft tissue injuries (SSTI). This study evaluated the relationship between partial ejection and UE injuries, notably SSTIs, in MVCs focusing on crash types and characteristics, and further examined the role of side curtain airbags (SCABs) in the prevention of partial ejection and reducing SSTI of the UE. METHODS: Weighted data was analyzed from the National Automotive Sampling System Crashworthiness Data System (NASS-CDS) from 1993 to 2012...
May 2017: Accident; Analysis and Prevention
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