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Chang Liu, Joyce C Pressley
BACKGROUND: Most studies of rear-seated occupants have focused on or included pediatric occupants which may not translate to adults. This study examines passenger, driver, vehicle and crash characteristics for rear-seated adult occupants involved in side crashes. METHODS: The National Automotive Sampling System General Estimates System (NASS/GES) for calendar years 2011-2014 was used with accompanying weights to examine the occupant, vehicle and crash characteristics associated with injury in rear-seated adults (n = 395,504) involved in a side crash...
December 2016: Injury Epidemiology
Amit Modgil, Manasa L Parakala, Mike A Ackley, James J Doherty, Stephen J Moss, Paul A Davies
The neuroactive steroid (NAS) tetrahydrodeoxycorticosterone (THDOC) increases protein kinase C (PKC) mediated phosphorylation of extrasynaptic GABAA receptor (GABAAR) subunits leading to increased surface expression of α4/β3 subunit-containing extrasynaptic GABAARs, leading to a sustained increase in GABAAR tonic current density. Whether other naturally occurring and synthetic NASs share both an allosteric and metabotropic action on GABAARs is unknown. Here, we examine the allosteric and metabotropic properties of allopregnanolone (ALLO), and synthetic NASs SGE-516 and ganaxolone...
October 12, 2016: Neuropharmacology
Catia Cilene Nass Sebrão, Arandi Ginane Bezerra Junior, Paulo Henrique Condeixa de França, Leslie Ecker Ferreira, Vania Portela Ditzel Westphalen
The aim of this in vitro study was to compare the efficiency of a photodynamic therapy (PDT) technique employing rose bengal (RB) and methylene blue (MB) as photosensitizers (PSs) to reduce the viability of Enterococcus faecalis, a well-known pathogen found in root canal systems. Currently, in several clinical applications, including in the field of endodontics, MB is employed in association with a red laser source for the photoinactivation of pathogenic bacteria. Here, it was used at 0.01% (31.2 mol/L) in association with a red (660 nm) laser as the excitation source in the MB group (MBG)...
September 9, 2016: Photomedicine and Laser Surgery
D Scott Kreiner, Jamie Baisden, Daniel J Mazanec, Rakesh D Patel, Robert S Bess, Douglas Burton, Norman B Chutkan, Bernard A Cohen, Charles H Crawford, Gary Ghiselli, Amgad S Hanna, Steven W Hwang, Cumhur Kilincer, Mark E Myers, Paul Park, Karie A Rosolowski, Anil K Sharma, Christopher K Taleghani, Terry R Trammell, Andrew N Vo, Keith D Williams
BACKGROUND CONTEXT: The North American Spine Society's (NASS) Evidence-Based Clinical Guideline for the Diagnosis and Treatment of Adult Isthmic Spondylolisthesis features evidence-based recommendations for diagnosing and treating adult patients with isthmic spondylolisthesis. The guideline is intended to reflect contemporary treatment concepts for symptomatic isthmic spondylolisthesis as reflected in the highest quality clinical literature available on this subject as of June 2013. NASS' guideline on this topic is the only guideline on adult isthmic spondylolisthesis accepted in the Agency for Healthcare Research and Quality's National Guideline Clearinghouse...
September 1, 2016: Spine Journal: Official Journal of the North American Spine Society
Guoxin Fan, Ruoshuang Han, Xin Gu, Hailong Zhang, Xiaofei Guan, Yunshan Fan, Teng Wang, Shisheng He
PURPOSE: Beginners usually need increased punctures and dozens of fluoroscopy in learning transforamimal percutaneous endoscopic lumbar discectomy (tPELD). Navigator-assisted spinal surgery (NASS) is a novel technique that could induce a definite trajectory. The retrospective study aimed to investigate the impact of a definite trajectory on the learning curve of tPELD. METHODS: A total of 120 patients with symptomatic lumbar disc herniation who received tPELD between 2012 and 2014...
September 3, 2016: International Orthopaedics
Patricia C Dischinger, Joseph A Kufera, Shiu M Ho, Gabriel E Ryb, Stewart Wang
OBJECTIVES: The objective of the current study was to examine trends in ankle/foot (A/F) injuries during the period 2001-2014, in order to determine whether the incidence of these injuries has changed and whether a previously identified difference in risk by gender still existed. In addition, other driver and crash-related risk factors were examined separately for men and women. METHODS: Passenger vehicle drivers aged 16+ were identified from NASS-CDS; weighted data were analyzed for model years 2001-2014...
September 2016: Traffic Injury Prevention
Derek A Jones, James P Gaewsky, Mireille E Kelley, Ashley A Weaver, Anna N Miller, Joel D Stitzel
INTRODUCTION: The objective of this study was to reconstruct 4 real-world motor vehicle crashes (MVCs), 2 with lumbar vertebral fractures and 2 without vertebral fractures in order to elucidate the MVC and/or restraint variables that increase this injury risk. METHODS: A finite element (FE) simplified vehicle model (SVM) was used in conjunction with a previously developed semi-automated tuning method to arrive at 4 SVMs that were tuned to mimic frontal crash responses of a 2006 Chevrolet Cobalt, 2012 Ford Escape, 2007 Hummer H3, and 2002 Chevrolet Cavalier...
September 2016: Traffic Injury Prevention
Samantha L Schoell, Ashley A Weaver, Jennifer W Talton, Gretchen Baker, Andrea N Doud, Ryan T Barnard, Joel D Stitzel, Mark R Zonfrillo
OBJECTIVE: The objective of the study was to develop a disability-based metric for motor vehicle crash (MVC) injuries, with a focus on head injuries, and compare the functional outcomes between the pediatric and adult populations. METHODS: Disability risk (DR) was quantified using Functional Independence Measure (FIM) scores within the National Trauma Data Bank-Research Data System (NTDB-RDS) for the top 95% most frequently occurring Abbreviated Injury Scale (AIS) 3, 4, and 5 head injuries in NASS-CDS 2000-2011...
September 2016: Traffic Injury Prevention
Eda K Holl, Kara L Shumansky, Luke B Borst, Angela D Burnette, Christopher J Sample, Elizabeth A Ramsburg, Bruce A Sullenger
Nucleic acid-containing debris released from dead and dying cells can be recognized as damage-associated molecular patterns (DAMPs) or pattern-associated molecular patterns (PAMPs) by the innate immune system. Inappropriate activation of the innate immune response can engender pathological inflammation and autoimmune disease. To combat such diseases, major efforts have been made to therapeutically target the pattern recognition receptors (PRRs) such as the Toll-like receptors (TLRs) that recognize such DAMPs and PAMPs, or the downstream effector molecules they engender, to limit inflammation...
August 30, 2016: Proceedings of the National Academy of Sciences of the United States of America
G Guidoboni, E Stephenson, S Andrianov, W Augustyniak, Z Bagdasarian, M Bai, M Baylac, W Bernreuther, S Bertelli, M Berz, J Böker, C Böhme, J Bsaisou, S Chekmenev, D Chiladze, G Ciullo, M Contalbrigo, J-M de Conto, S Dymov, R Engels, F M Esser, D Eversmann, O Felden, M Gaisser, R Gebel, H Glückler, F Goldenbaum, K Grigoryev, D Grzonka, T Hahnraths, D Heberling, V Hejny, N Hempelmann, J Hetzel, F Hinder, R Hipple, D Hölscher, A Ivanov, A Kacharava, V Kamerdzhiev, B Kamys, I Keshelashvili, A Khoukaz, I Koop, H-J Krause, S Krewald, A Kulikov, A Lehrach, P Lenisa, N Lomidze, B Lorentz, P Maanen, G Macharashvili, A Magiera, R Maier, K Makino, B Mariański, D Mchedlishvili, Ulf-G Meißner, S Mey, W Morse, F Müller, A Nass, G Natour, N Nikolaev, M Nioradze, K Nowakowski, Y Orlov, A Pesce, D Prasuhn, J Pretz, F Rathmann, J Ritman, M Rosenthal, Z Rudy, A Saleev, T Sefzick, Y Semertzidis, Y Senichev, V Shmakova, A Silenko, M Simon, J Slim, H Soltner, A Stahl, R Stassen, M Statera, H Stockhorst, H Straatmann, H Ströher, M Tabidze, R Talman, P Thörngren Engblom, F Trinkel, A Trzciński, Yu Uzikov, Yu Valdau, E Valetov, A Vassiliev, C Weidemann, C Wilkin, A Wrońska, P Wüstner, M Zakrzewska, P Zuprański, D Zyuzin
We observe a deuteron beam polarization lifetime near 1000 s in the horizontal plane of a magnetic storage ring (COSY). This long spin coherence time is maintained through a combination of beam bunching, electron cooling, sextupole field corrections, and the suppression of collective effects through beam current limits. This record lifetime is required for a storage ring search for an intrinsic electric dipole moment on the deuteron at a statistical sensitivity level approaching 10^{-29}  e cm.
July 29, 2016: Physical Review Letters
Johan Iraeus, Mats Lindquist
OBJECTIVE: Frontal crashes still account for approximately half of all fatalities in passenger cars, despite several decades of crash-related research. For serious injuries in this crash mode, several authors have listed the thorax as the most important. Computer simulation provides an effective tool to study crashes and evaluate injury mechanisms, and using stochastic input data, whole populations of crashes can be studied. The aim of this study was to develop a generic buck model and to validate this model on a population of real-life frontal crashes in terms of the risk of rib fracture...
October 2016: Accident; Analysis and Prevention
Jennifer F Kawwass, Sara Crawford, Heather S Hipp, Sheree L Boulet, Dmitry M Kissin, Denise J Jamieson
BACKGROUND: Limited published data exist detailing outcomes of donor embryo cycles. Patients and clinicians would benefit from information specific to donor embryo cycles to inform fertility treatment options, counseling, and clinical decision-making. OBJECTIVE: To quantify trends in donor embryo cycles in the United States (US), to characterize donor embryo recipients, and to report transfer, pregnancy, and birth outcomes of donor embryo transfers. STUDY DESIGN: This retrospective cohort study of frozen donor embryo transfers uses data from Centers for Disease Control and Prevention's National ART Surveillance System to quantify trends in the use of donor embryos and corresponding rates of pregnancy and live birth from 2000-2013...
July 5, 2016: American Journal of Obstetrics and Gynecology
D Daniels, D Guez, D Last, C Hoffmann, D Nass, A Talianski, G Tsarfaty, S Salomon, A A Kanner, D T Blumenthal, F Bokstein, S Harnof, D Yekutieli, S Zamir, Z R Cohen, L Zach, Y Mardor
BACKGROUND AND PURPOSE: The interpretation of the radiologic response of bevacizumab-treated patients with recurrent high-grade gliomas represents a unique challenge. Delayed-contrast MR imaging was recently introduced for calculating treatment-response-assessment maps in patients with brain tumors, providing clear separation between active tumor and treatment effects. We studied the application of standard and delayed-contrast MR imaging for assessing and predicting the response to bevacizumab...
July 7, 2016: AJNR. American Journal of Neuroradiology
Max Seidensticker, Sebastian Streit, Norbert Nass, Christian Wybranski, Julian Jürgens, Jan Brauner, Nadine Schulz, Thomas Kalinski, Ricarda Seidensticker, Benjamin Garlipp, Ingo Steffen, Jens Ricke, Oliver Dudeck
PURPOSE: We aimed to assess the feasibility, efficacy and safety of a local application of sorafenib within a conventional transarterial chemoembolization in the VX-2 tumor-bearing rabbit model. METHODS: VX-2 tumors were induced in the left liver lobe of 10 New Zealand White rabbits. After two weeks, growth was verified by contrast-enhanced computed tomography (CT). Five rabbits were treated by transarterial chemoembolization using an emulsion of sorafenib and ethiodized oil (referred to as SORATACE; n=5)...
July 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Adam E M Eltorai, Morgan Cheatham, Syed S Naqvi, Siddharth Marthi, Victor Dang, Mark A Palumbo, Alan H Daniels
STUDY DESIGN: Analysis of spine-related patient education materials (PEMs) from subspecialty websites. OBJECTIVE: The aim of this study was to assess the readability of spine-related PEMs and compare to readability data from 2008. SUMMARY OF BACKGROUND DATA: Many spine patients use the Internet for health information. Several agencies recommend that the readability of online PEMs should be no greater than a sixth-grade reading level, as health literacy predicts health-related quality of life outcomes...
June 2016: Spine
Greg Shaw, David Lessley, Joseph Ash, Jerry Poplin, Tim McMurry, Mark Sochor, Jeff Crandall
OBJECTIVES: The two objectives of this study are to 1) examine the rib and sternal fractures sustained by small stature elderly females in simulated frontal crashes and 2) determine how the findings are characterized by prior knowledge and field data. METHODS: A test series was conducted to evaluate the response of five elderly (average age 76 years) female PMHS subjects, similar in mass and size to a 5th percentile female, in 30 km/h frontal sled tests. The subjects were restrained on a rigid planar seat by bilateral rigid knee bolsters, pelvic blocks, and a custom force-limited three-point shoulder and lap belt...
June 3, 2016: Traffic Injury Prevention
Van T Tong, Dmitry M Kissin, Dana Bernson, Glenn Copeland, Sheree L Boulet, Yujia Zhang, Denise J Jamieson, Lucinda J England
OBJECTIVE: To estimate smoking prevalence during the year before pregnancy and during pregnancy and adverse outcomes among women who delivered infants with and without assisted reproductive technology (ART) using linked birth certificates (BC) and National ART Surveillance System (NASS) data. METHODS: Data were analyzed for 384,390 women and 392,248 infants born in Massachusetts and Michigan during 2008-2009. Maternal smoking prevalence was estimated using smoking indicated from BC by ART status...
May 31, 2016: Journal of Women's Health
Ozlem Bingol, Cuneyt Ayrık, Ataman Kose, Seyran Bozkurt, Huseyin Narcı, Didem Ovla, Meltem Nass Duce
OBJECTIVES: Using whole-body multislice computed tomography (MSCT) excessively or with irrelevant indications can be seen in many centers. The aim of this study was to analyze retrospectively the MSCT findings in trauma patients admitted to the emergency department. METHODS: Records of the patients who have applied to the emergency department due to blunt trauma in a 12 month period and whose whole body MSCT images have been taken, were evaluated using the "Nucleus Medical Information System"...
September 2015: Turkish Journal of Emergency Medicine
Norbert Nass, Angela Dittmer, Vicky Hellwig, Theresia Lange, Johanna Mirjam Beyer, Benjamin Leyh, Atanas Ignatov, Christine Weiβenborn, Tove Kirkegaard, Anne E Lykkesfeldt, Thomas Kalinski, Jürgen Dittmer
We have previously shown that stromal cells desensitize breast cancer cells to the anti-estrogen fulvestrant and, along with it, downregulate the expression of TMEM26 (transmembrane protein 26). In an effort to study the function and regulation of TMEM26 in breast cancer cells, we found that breast cancer cells express non-glycosylated and N-glycosylated isoforms of the TMEM26 protein and demonstrate that N-glycosylation is important for its retention at the plasma membrane. Fulvestrant induced significant changes in expression and in the N-glycosylation status of TMEM26...
May 20, 2016: Oncotarget
Katsutaka Oishi, Sayaka Higo-Yamamoto, Yuki Yasumoto
OBJECTIVES: Caloric sweeteners such as sugar and honey are replaced in thousands of food products by noncaloric artificial sweeteners (NASs). The aim of the present study was to determine the effects of chronic NAS intake on circadian sleep regulation. METHODS: Circadian rhythms of sleep and locomotor activity were evaluated in mice after consumption of drinking water containing 0.1% (w/v) saccharin for 2 wk. RESULTS: The intake of saccharin ad libitum significantly reduced wakefulness and increased non-rapid eye movement sleep during the first half of the active (dark) phase, whereas wakefulness was significantly increased at the start of the sleep phase...
October 2016: Nutrition
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