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https://www.readbyqxmd.com/read/29329787/outcomes-of-multisegmental-transforaminal-enlarged-decompression-plus-posterior-pedicle-screw-fixation-for-multilevel-lumbar-spinal-canal-stenosis-associated-with-lumbar-instability
#1
Chao Sun, Wei Ji Tian, Hui Xin Liu, Ping Guo Guan
PURPOSE: The aim of this study was to evaluate the clinical and radiologic results of multisegmental transforaminal enlarged decompression (TED) plus posterior pedicle screw fixation in the treatment of multilevel lumbar spinal canal stenosis (LSCS) with lumbar instability (MLSCSI). METHODS: 113 patients with MLSCSI underwent surgery were recruited in this study. All patients were suffering from symptoms typical of degenerative LSCS and treated with either TED plus fusion (TEDF group) or conventional laminectomy plus fusion (CLF group)...
January 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29322966/the-influence-of-adjunctive-caudal-epidural-steroid-injection-on-the-therapeutic-effect-of-transforaminal-epidural-steroid-injection
#2
Atilla Kircelli, Tufan Cansever, Cem Yılmaz
BACKGROUND: Epidural steroid injection is widely used to treat the short and long-term symptoms of low back and radicular pain. To the best of our knowledge, the influence of transforaminal epidural steroid injection (TFSI) combined with caudal epidural steroid injection (CESI) on pain intensity, patient satisfaction, and quality of life in lumbar radiculopathy has not been examined. AIM: To evaluate the short and long-term efficacy of TFSI, and TFSI combined with CESI (TFSI + CESI) in patients with lumbar radiculopathy...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29290130/women-fare-best-following-surgery-for-degenerative-lumbar-spondylolisthesis-a-comparison-of-the-most-and-least-satisfied-patients-utilizing-data-from-the-quality-outcomes-database
#3
Andrew K Chan, Erica F Bisson, Mohamad Bydon, Steven D Glassman, Kevin T Foley, Eric A Potts, Christopher I Shaffrey, Mark E Shaffrey, Domagoj Coric, John J Knightly, Paul Park, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Panagiotis Kerezoudis, Silky Chotai, Anthony M DiGiorgio, Alvin Y Chan, Regis W Haid, Praveen V Mummaneni
OBJECTIVE The American Association of Neurological Surgeons launched the Quality Outcomes Database (QOD), a prospective longitudinal registry that includes demographic, clinical, and patient-reported outcome (PRO) data, to measure the safety and quality of neurosurgical procedures, including spinal surgery. Differing results from recent randomized controlled trials have established a need to clarify the groups that would most benefit from surgery for degenerative lumbar spondylolisthesis. In the present study, the authors compared patients who were the most and the least satisfied following surgery for degenerative lumbar spondylolisthesis...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29289303/determination-of-ultra-trace-level-of-232th-in-seawater-by-icp-sfms-after-matrix-separation-and-preconcentration
#4
Irena Wysocka, Emilia Vassileva
This article describes the development and validation of an analytical procedure for the matrix separation, preconcentration and determination of sub-ng kg-1 levels 232Th in a small volume (20 mL) of seawater samples. The matrix separation and Th preconcentration was carried out using a commercially available ion-chelation system seaFAST-pico. The acidified to pH < 2 seawater samples were mixed on-line with the ammonium acetate buffer (pH of 6.0 ± 0.2) before loading on the column containing resin with iminodiacetic and ethylenediaminetriacetic functional groups...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29287819/adult-spinal-deformity-knowledge-in-orthopedic-spine-surgeons-impact-of-fellowship-training-experience-and-practice-characteristics
#5
Zachary J Grabel, Robert A Hart, Aaron P Clark, Sara Heejung Park, Christopher I Shaffrey, Justin K Scheer, Justin S Smith, Michael P Kelly, J Mason DePasse, Munish C Gupta, Christopher P Ames, Alan H Daniels
STUDY DESIGN: Survey study. OBJECTIVE: The purpose of this paper was to assess the level of adult spine deformity (ASD) knowledge among orthopedic spine surgeons and identify areas for improvement in spine surgery training. SUMMARY OF BACKGROUND DATA: ASD is increasingly encountered in spine surgery practice. While ASD knowledge among neurosurgeons has been evaluated, ASD knowledge among orthopedic spine surgeons has not previously been reported...
January 2018: Spine Deformity
https://www.readbyqxmd.com/read/29246275/reducible-complexity-nass-2017-presidential-address
#6
EDITORIAL
F Todd Wetzel
No abstract text is available yet for this article.
January 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29234001/revisiting-unexploited-antibiotics-in-search-of-new-antibacterial-drug-candidates-the-case-of-%C3%AE-actinorhodin
#7
Nada M Nass, Sannia Farooque, Charlotte Hind, Matthew E Wand, Christopher P Randall, J Mark Sutton, Ryan F Seipke, Christopher M Rayner, Alex J O'Neill
Of the thousands of natural product antibiotics discovered to date, only a handful have been developed for the treatment of bacterial infection. The clinically unexploited majority likely include compounds with untapped potential as antibacterial drugs, and in view of the ever-growing unmet medical need for such agents, warrant systematic re-evaluation. Here we revisit the actinorhodins, a class that was first reported 70 years ago, but which remains poorly characterized. We show that γ-actinorhodin possesses many of the requisite properties of an antibacterial drug, displaying potent and selective bactericidal activity against key Gram-positive pathogens (including Staphylococcus aureus and enterococci), a mode of action distinct from that of other agents in clinical use, an extremely low potential for the development of resistance, and a degree of in vivo efficacy in an invertebrate model of infection...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231920/two-colour-serial-femtosecond-crystallography-dataset-from-gadoteridol-derivatized-lysozyme-for-mad-phasing
#8
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R Bruce Doak, Marie Luise Grünbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Nass Kovács, Eriko Nango, Karol Nass, Christopher M Roome, Robert L Shoeman, Rie Tanaka, Kensuke Tono, Lutz Foucar, Yasumasa Joti, Makina Yabashi, So Iwata, Kiyoshi Ueda, Thomas R M Barends, Ilme Schlichting
We provide a detailed description of a gadoteridol-derivatized lysozyme (gadolinium lysozyme) two-colour serial femtosecond crystallography (SFX) dataset for multiple wavelength anomalous dispersion (MAD) structure determination. The data was collected at the Spring-8 Angstrom Compact free-electron LAser (SACLA) facility using a two-colour double-pulse beam to record two diffraction patterns simultaneously in one diffraction image. Gadolinium lysozyme was chosen as a well-established model system that has a very strong anomalous signal...
December 12, 2017: Scientific Data
https://www.readbyqxmd.com/read/29223589/breakthroughs-in-neuroactive-steroid-drug-discovery
#9
REVIEW
Maria-Jesus Blanco, Daniel La, Quinn Coughlin, Caitlin A Newman, Andrew M Griffin, Boyd L Harrison, Francesco G Salituro
Endogenous and synthetic neuroactive steroids (NASs) or neurosteroids are effective modulators of multiple signaling pathways including receptors for the γ-aminobutyric acid A (GABAA) and glutamate, in particular N-methyl-d-aspartate (NMDA). These receptors are the major inhibitory and excitatory neurotransmitters in the central nervous system (CNS), and there is growing evidence suggesting that dysregulation of neurosteroid production plays a role in numerous neurological disorders. The significant unmet medical need for treatment of CNS disorders has increased the interest for these types of compounds...
December 2, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29185794/the-effect-of-correct-cross-chest-clip-use-on-injury-outcomes-in-young-children-during-motor-vehicle-crashes
#10
Evangeline Woodford, Julie Brown, Lynne E Bilston
OBJECTIVE: Traffic crashes have high mortality and morbidity for young children. While many specialised child restraint systems improve injury outcomes, no large-scale studies have investigated the cross-chest clip's role during a crash, despite concerns in some jurisdictions about the potential for neck contact injuries from the clips. This study aimed to investigate the relationship between cross-chest clip use and injury outcomes in children between 0-4 years of age. METHODS: Child passengers between 0-4 years of age were selected from the Crashworthiness Data System of the US National Automotive Sampling System (NASS) datasets (2003-2014)...
November 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29175832/rear-facing-versus-forward-facing-child-restraints-an-updated-assessment
#11
Timothy L McMurry, Kristy B Arbogast, Christopher P Sherwood, Federico Vaca, Marilyn Bull, Jeff R Crandall, Richard W Kent
OBJECTIVES: The National Highway Traffic Safety Administration and the American Academy of Pediatrics recommend children be placed in rear-facing child restraint systems (RFCRS) until at least age 2. These recommendations are based on laboratory biomechanical tests and field data analyses. Due to concerns raised by an independent researcher, we re-evaluated the field evidence in favour of RFCRS using the National Automotive Sampling System Crashworthiness Data System (NASS-CDS) database...
November 25, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29165798/weight-management-and-physical-activity-throughout-the-cancer-care-continuum
#12
Wendy Demark-Wahnefried, Kathryn H Schmitz, Catherine M Alfano, Jennifer R Bail, Pamela J Goodwin, Cynthia A Thomson, Don W Bradley, Kerry S Courneya, Christie A Befort, Crystal S Denlinger, Jennifer A Ligibel, William H Dietz, Melinda R Stolley, Melinda L Irwin, Marcas M Bamman, Caroline M Apovian, Bernardine M Pinto, Kathleen Y Wolin, Rachel M Ballard, Andrew J Dannenberg, Elizabeth G Eakin, Matt M Longjohn, Susan D Raffa, Lucile L Adams-Campbell, Joanne S Buzaglo, Sharyl J Nass, Greta M Massetti, Erin P Balogh, Elizabeth S Kraft, Anand K Parekh, Darshak M Sanghavi, G Stephen Morris, Karen Basen-Engquist
Mounting evidence suggests that weight management and physical activity (PA) improve overall health and well being, and reduce the risk of morbidity and mortality among cancer survivors. Although many opportunities exist to include weight management and PA in routine cancer care, several barriers remain. This review summarizes key topics addressed in a recent National Academies of Science, Engineering, and Medicine workshop entitled, "Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum...
November 22, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29165586/extent-of-physician-pharmaceutical-industry-interactions-in-low-and-middle-income-countries-a-systematic-review
#13
Racha Fadlallah, Lina Alkhaled, Hneine Brax, Mayse Nasser, Mhd Hashem Rajabbik, Hala Nass, Lara A Kahale, Elie A Akl
Background: Pharmaceutical companies spend large amounts of money promoting their products to physicians. There is evidence that physicians' interactions with pharmaceutical companies negatively affect their prescribing patterns. The objective of this study was to systematically review the extent of the relationship between physicians and pharmaceutical companies in low- and middle-income countries (LMICs). Methods: Studies assessing the extent of any type of interaction between practicing physicians and pharmaceutical companies were eligible...
November 20, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29136865/a-catalytic-spectrophotometric-method-for-determination-of-nanomolar-manganese-in-seawater-using-reverse-flow-injection-analysis-and-a-long-path-length-liquid-waveguide-capillary-cell
#14
Sichao Feng, Dongxing Yuan, Yongming Huang, Kunning Lin, Yong Zhu, Jian Ma
A sensitive and precise method for determination of nanomolar manganese in seawater was developed, using reverse flow injection analysis, a long path length liquid waveguide capillary cell, and spectrophotometric detection. The reaction was based on manganese catalyzed oxidation of leucomalachite green with sodium periodate. Various experimental parameters were investigated and optimized. Foreign trace metal ions of iron, copper, zinc, nickel and aluminum did not cause obvious interference with manganese detection...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29114274/outcomes-of-minimally-invasive-surgery-compared-to-open-posterior-lumbar-instrumentation-and-fusion
#15
Low Yong Lee, Zamzuri Idris, Tan Boon Beng, Teo Yian Young, Wong Chung Chek, Jafri Malin Abdullah, Wong Sii Hieng
Introduction: Degenerative spine disease is increasingly common. There are many spinal fusion techniques used to treat degenerative spine disease. This study aims to compare the functional outcome of open versus minimally invasive surgery (MIS) technique in posterior lumbar instrumentation and fusion in degenerative spine disease and to evaluate the perioperative outcome and complications between MIS and open surgery. Materials and Methods: This is an observational cross-sectional study conducted on all degenerative spine disease patients who underwent both methods of posterior lumbar instrumentation and fusion from 2010 to 2014 by the Orthopedic and Neurosurgery Department, Sarawak General Hospital...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29079797/multi-wavelength-anomalous-diffraction-de-novo-phasing-using-a-two-colour-x-ray-free-electron-laser-with-wide-tunability
#16
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R Bruce Doak, Marie Luise Grünbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Kovácsová, Eriko Nango, Karol Nass, Christopher M Roome, Robert L Shoeman, Rie Tanaka, Kensuke Tono, Yasumasa Joti, Makina Yabashi, So Iwata, Lutz Foucar, Kiyoshi Ueda, Thomas R M Barends, Ilme Schlichting
Serial femtosecond crystallography at X-ray free-electron lasers (XFELs) offers unprecedented possibilities for macromolecular structure determination of systems prone to radiation damage. However, de novo structure determination, i.e., without prior structural knowledge, is complicated by the inherent inaccuracy of serial femtosecond crystallography data. By its very nature, serial femtosecond crystallography data collection entails shot-to-shot fluctuations in X-ray wavelength and intensity as well as variations in crystal size and quality that must be averaged out...
October 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29045166/driver-injury-in-near-and-far-side-impacts-update-on-the-effect-of-front-passenger-belt-use
#17
Chantal S Parenteau, David C Viano
PURPOSE: This is a study that updates earlier research on the influence of a front passenger on the risk for severe driver injury in near-side and far-side impacts. It includes the effects of belt use by the driver and passenger, identifies body regions involved in driver injury and identifies the sources for severe, driver head injury. METHODS: 1997-2015 NASS-CDS data was used to investigate the risk for MAIS 4+F driver injury in near-side and far-side impacts by front-passenger belt use and as a sole occupant in the driver seat...
October 18, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28983299/deletion-of-the-l-lactate-dehydrogenase-gene-ldh-in-streptococcus-pyogenes-leads-to-a-loss-of-speb-activity-and-a-hypovirulent-phenotype
#18
Sonja Oehmcke-Hecht, Leif E Nass, Jan B Wichura, Stefan Mikkat, Bernd Kreikemeyer, Tomas Fiedler
Streptococcus pyogenes uses lactic acid fermentation for the generation of ATP. Here, we analyzed the impact of a deletion of the L-lactate dehydrogenase gene ldh on the virulence of S. pyogenes M49. While the ldh deletion does not cause a general growth deficiency in laboratory media, the growth in human blood and plasma is significantly hampered. The ldh deletion strain is furthermore less virulent in a Galleria mellonella infection model. We show that the ldh deletion leads to a decrease in the activity of the cysteine protease SpeB, an important secreted virulence factor of S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28970074/effect-of-patients-functional-status-on-satisfaction-with-outcomes-12-months-after-elective-spine-surgery-for-lumbar-degenerative-disease
#19
Silky Chotai, Clinton J Devin, Kristin R Archer, Mohamad Bydon, Matthew J McGirt, Hui Nian, Frank E Harrell, Robert S Dittus, Anthony L Asher
BACKGROUND: Comprehensive assessment of quality of care includes patient-reported outcomes, safety of care delivered, and patient satisfaction. The impact of the patient-reported Oswestry Disability Index (ODI) scores at baseline and 12 months on satisfaction with outcomes following spine surgery is not well documented. PURPOSE: This study aimed to determine the impact of patient disability (ODI) scores at baseline and 12 months on satisfaction with outcomes following surgery...
December 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28944276/verification-of-neonatal-tetanus-surveillance-systems-in-katsina-state-nigeria
#20
Shafique Sani Nass, Hadi Danawi, Loretta Cain, Monoj Sharma
BACKGROUND: The incidence and mortality rates of neonatal tetanus (NNT) remain underreported in Nigeria. The goal of the study was to compare the NNT prevalence and the mortality rates from the existing surveillance system and active surveillance of health facility records in 7 selected health facilities from 2010 to 2014 in Katsina State, Nigeria. METHODS: The study is a retrospective record review using extracted data from NNT records and analyzed using descriptive statistics...
January 2017: Health Services Research and Managerial Epidemiology
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