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https://www.readbyqxmd.com/read/28102701/the-effect-of-pre-crash-velocity-reduction-on-occupant-response-using-a-human-body-finite-element-model
#1
B Guleyupoglu, J Schap, K D Kusano, F S Gayzik
OBJECTIVE: The objective of this study is to use a validated finite element model of the human body and a certified model of an ATD to evaluate the effect of simulated pre-crash braking on driver kinematics, restraint loads, body loads and computed injury criteria in four commonly-injured body regions. METHODS: The Global Human Body Models Consortium (GHBMC) 50th percentile male occupant (M50-O) and the Humanetics Hybrid-III 50(th) percentile models were gravity settled in the driver position of a generic interior equipped with an advanced three point belt and driver airbag...
January 19, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28058555/commentary-on-the-consensus-statement-of-the-american-society-of-breast-surgeons-on-contralateral-prophylactic-mastectomy
#2
EDITORIAL
Sharyl J Nass, Larissa Nekhlyudov
The increasing rate of contralateral prophylactic mastectomy (CPM) led the American Society of Breast Surgeons (ASBrS) to issue an evidence-based consensus statement on CPM, as well as a discussion guide that health care providers can use to facilitate shared decision making with patients considering CPM for unilateral breast cancer. This article suggests several ways to improve the discussion guide by eliciting patient values and preferences and by providing more current, detailed, and balanced information about the potential risks and benefits of CPM...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28049054/monodisperse-raspberry-like-multihollow-polymer-ag-nanocomposite-microspheres-for-rapid-catalytic-degradation-of-methylene-blue
#3
Qiong Tian, Xiaojing Yu, Lifeng Zhang, Demei Yu
Raspberry-like multihollow polymer microspheres were prepared by seeded swelling polymerization and decorated with silver nanoparticles (AgNPs) in the presence of polyvinylpyrrolidone (PVP) which acted as both reducing and stabilizing agent. Formation mechanism of the raspberry-like multihollow microsphere was discussed on the basis of water absorption of sulfonated groups in the seeded swelling polymerization. Effects of weight ratio of sodium 4-vinylbenzenesulfonate to styrene (NaSS/St) of the seed particles, the concentration of PVP and [Ag(NH3)2](+) ions on the properties of polymer/Ag nanocomposite microspheres were investigated by microscopic observation, nitrogen adsorption/desorption isotherms, UV-vis absorption spectra, X-ray diffraction patterns and thermogravimetric analysis...
December 23, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28038958/temporal-and-spatial-expression-pattern-of-nnat-during-mouse-eye-development
#4
Saadettin Sel, Eva Patzel, Lucia Poggi, Delia Kaiser, Thomas Kalinski, Martin Schicht, Friedrich Paulsen, Norbert Nass
BACKGROUND: Neuronatin (Nnat) was initially identified as a highly expressed gene in neonatal mammalian brain. In this study, we analyze the spatial and temporal expression pattern of Nnat during mouse eye development as well as in the adult. METHODS: The expression of Nnat was analyzed on mRNA as well as protein level. The presence of Nnat transcripts in the adult retina was examined using reverse transcription-polymerase chain reaction (RT-PCR). Nnat protein expression was evaluated by Western blot and immunohistochemistry during eye development at embryonic day (E) 12, 15, 16 and postnatal day (P) 7, 14, 30 and 175 (adult)...
December 27, 2016: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28012130/accumulation-of-the-advanced-glycation-end-product-carboxymethyl-lysine-in-breast-cancer-is-positively-associated-with-estrogen-receptor-expression-and-unfavorable-prognosis-in-estrogen-receptor-negative-cases
#5
Norbert Nass, Atanas Ignatov, Ludwig Andreas, Christine Weißenborn, Thomas Kalinski, Saadettin Sel
Advanced glycation end products (AGEs) accumulate as a result of high concentrations of reactive aldehydes, oxidative stress, and insufficient degradation of glycated proteins. AGEs are therefore accepted biomarkers for aging, diabetes, and several degenerative diseases. Due to the Warburg effect and increased oxidative stress, cancer cells frequently accumulate significant amounts of AGEs. As the accumulation of AGEs may reflect the metabolic state and receptor signaling, we evaluated the potential prognostic and predictive value of this biomarker...
December 23, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28011478/validation-of-vx2-as-a-hepatocellular-carcinoma-model-comparison-of-the-molecular-reaction-of-vx2-and-hepg2-tumor-cells-to-sorafenib-in-vitro
#6
Norbert Nass, Sebastian Streit, Christian Wybranski, Julian Jürgens, Jan Brauner, Nadine Schulz, Maciej Powerski, Jens Ricke, Thomas Kalinski, Oliver Dudeck, Max Seidensticker
As there is currently no superior hepatocellular carcinoma (HCC) model with percutaneous vascular access for transarterial treatments available, the VX2 rabbit model is frequently used for in vivo investigations on liver carcinoma. However, the VX2 cell line was derived from a virus-induced skin papilloma that can form carcinosarcoma in liver of rabbits and the transferability of obtained results to HCC treatment remains open. Here we compared the most frequently investigated human HCC model cell line, HepG2, with VX2 cells in vitro in terms of sensitivity towards the broad specificity kinase inhibitor sorafenib and responsiveness to the addition of platelet-derived growth factor AB (PDGF-AB), vascular endothelial growth factor (VEGF) and hepatic growth factor (HGF), as well as insulin and interleukin-1β (IL1β)...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/27994786/bone-morphogenic-protein-is-a-viable-adjunct-for-fusion-in-minimally-invasive-transforaminal-lumbar-interbody-fusion
#7
M Mashfiqul Arafin Siddiqui, Ana Rosario P Sta Ana, William Yeo, Wai-Mun Yue
STUDY DESIGN: Comparison of prospectively collected data of patients undergoing minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF) with and without recombinant human bone morphogenic protein 2 (BMP). PURPOSE: To compare the clinical, radiological outcome and complications of patients undergoing MIS-TLIF with and without BMP. OVERVIEW OF LITERATURE: BMP is an effective fusion enhancer with potential complications. Direct comparison of MIS-TLIF with and without BMP is limited to retrospective studies with short follow-up...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27974387/decrease-of-serum-igf-i-following-transsphenoidal-pituitary-surgery-for-acromegaly
#8
Min Yu, David E Bruns, John A Jane, Ralf M Nass, Edward H Oldfield, Mary Lee Vance, Michael O Thorner
BACKGROUND: In the immediate postoperative period following resection of growth hormone (GH)-secreting pituitary tumors, serum concentrations of GH have limited ability to predict remission of acromegaly. Since many actions of GH actions are mediated by insulin-like growth factor-1 (IGF-I), we aimed to determine the rates of fall of IGF-I during 72 h after surgical resection of pituitary tumors. METHODS: We studied patients who were undergoing pituitary surgery for acromegaly...
December 14, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27941259/direct-determination-of-cadmium-in-seawater-by-standard-addition-icp-qms-qms-with-an-orc
#9
Yanbei Zhu, Akihide Itoh
A method for direct and precise determination of Cd in seawater by ICP-QMS/QMS was developed, where a high matrix introducing unit permitted the direct introduction of seawater without clogging the cones while the matrix effect of seawater was canceled by standard addition. NH3 gas was selected as the reaction gas for removing the MoO interferences with the measurement of Cd isotopes, effectively improving the signal to background ratio. The lower limit of detection obtained at (114)Cd was 0.0002 ng mL(-1), which is enough for the determination of Cd in natural seawater...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27932338/meaning-of-living-with-severe-chronic-obstructive-lung-disease-a-qualitative-study
#10
Gabriella Marx, Maximilian Nasse, Henrikje Stanze, Sonja Owusu Boakye, Friedemann Nauck, Nils Schneider
OBJECTIVES: To explore what it means for patients to live with chronic obstructive pulmonary disease (COPD) as an incurable and constantly progressing disease. DESIGN: Qualitative longitudinal study using narrative and semistructured interviews. This paper presents findings of the initial interviews. Analysis using grounded theory. SETTING: Lung care clinics and community care in Lower Saxony, Germany. PARTICIPANTS: 17 patients with advanced-stage COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) III/IV)...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27872345/hazards-of-cigarettes-smokeless-tobacco-and-waterpipe-in-a-middle-eastern-population-a-cohort-study-of-50%C3%A2-000-individuals-from-iran
#11
Arash Etemadi, Hooman Khademi, Farin Kamangar, Neal D Freedman, Christian C Abnet, Paul Brennan, Reza Malekzadeh
BACKGROUND: There is limited information about the hazards of cigarettes, smokeless tobacco and waterpipe in the Middle East. The aim of this study was to determine the association between different types of tobacco use and earlier death in the Golestan Cohort Study. METHODS: The Study includes 50 045 adults (aged 40-75 years) from north eastern Iran. The baseline questionnaire (2004-2008) assessed information about use of cigarettes, chewing tobacco (nass) and waterpipe...
November 21, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27871102/new-risk-curves-for-nhtsa-s-brain-injury-criterion-bric-derivations-and-assessments
#12
Tony R Laituri, Scott Henry, Kevin Pline, Guosong Li, Michael Frankstein, Para Weerappuli
The National Highway Traffic Safety Administration (NHTSA) recently published a Request for Comments regarding a potential upgrade to the US New Car Assessment Program (US NCAP) - a star-rating program pertaining to vehicle crashworthiness. Therein, NHTSA (a) cited two metrics for assessing head risk: Head Injury Criterion (HIC15) and Brain Injury Criterion (BrIC), and (b) proposed to conduct risk assessment via its risk curves for those metrics, but did not prescribe a specific method for applying them. Recent studies, however, have indicated that the NHTSA risk curves for BrIC significantly overstate field-based head injury rates...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27871101/morphomics-of-the-talus
#13
David Gorman, Ebram Handy, Sikui Wang, Annette L Irwin, Stewart Wang
Previous studies of frontal crash databases reported that ankle fractures are among the most common lower extremity fractures. While not generally life threatening, these injuries can be debilitating. Laboratory research into the mechanisms of ankle fractures has linked dorsiflexion with an increased risk of tibia and fibula malleolus fractures. However, talus fractures were not produced in the laboratory tests and appear to be caused by more complex loading of the joint. In this study, an analysis of the National Automotive Sampling System - Crashworthiness Data System (NASS-CDS) for the years 2004-2013 was conducted to investigate foot-ankle injury rates in front seat occupants involved in frontal impact crashes...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27871091/age-specific-injury-risk-curves-for-distributed-anterior-thoracic-loading-of-various-sizes-of-adults-based-on-sternal-deflections
#14
Harold J Mertz, Priya Prasad, Dainius J Dalmotas, Annette L Irwin
Injury Risk Curves are developed from cadaver data for sternal deflections produced by anterior, distributed chest loads for a 25, 45, 55, 65 and 75 year-old Small Female, Mid-Size Male and Large Male based on the variations of bone strengths with age. These curves show that the risk of AIS ≥ 3 thoracic injury increases with the age of the person. This observation is consistent with NASS data of frontal accidents which shows that older unbelted drivers have a higher risk of AIS ≥ 3 chest injury than younger drivers...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27846241/sprint-start-kinetics-of-amputee-and-non-amputee-sprinters
#15
Steffen Willwacher, Volker Herrmann, Kai Heinrich, Johannes Funken, Gerda Strutzenberger, Jan-Peter Goldmann, Björn Braunstein, Adam Brazil, Gareth Irwin, Wolfgang Potthast, Gert-Peter Brüggemann
The purpose of this study was to explore the relationship between the forces applied to the starting blocks and the start performances (SPs) of amputee sprinters (ASs) and non-amputee sprinters (NASs). SPs of 154 male and female NASs (100-m personal records [PRs], 9.58-14.00 s) and 7 male ASs (3 unilateral above knee, 3 unilateral below knee, 1 bilateral below knee; 100 m PRs, 11.70-12.70 s) with running specific prostheses (RSPs) were analysed during full-effort sprint starts using instrumented starting blocks that measured the applied forces in 3D...
2016: PloS One
https://www.readbyqxmd.com/read/27824451/frequency-comb-spectrum-of-periodic-patterned-signals
#16
Johannes L Steinmann, Edmund Blomley, Miriam Brosi, Erik Bründermann, Michele Caselle, Jeffrey L Hesler, Nicole Hiller, Benjamin Kehrer, Yves-Laurent Mathis, Michael J Nasse, Juliane Raasch, Manuel Schedler, Patrik Schönfeldt, Marcel Schuh, Markus Schwarz, Michael Siegel, Nigel Smale, Marc Weber, Anke-Susanne Müller
Using arbitrary periodic pulse patterns we show the enhancement of specific frequencies in a frequency comb. The envelope of a regular frequency comb originates from equally spaced, identical pulses and mimics the single pulse spectrum. We investigated spectra originating from the periodic emission of pulse trains with gaps and individual pulse heights, which are commonly observed, for example, at high-repetition-rate free electron lasers, high power lasers, and synchrotrons. The ANKA synchrotron light source was filled with defined patterns of short electron bunches generating coherent synchrotron radiation in the terahertz range...
October 21, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27747559/side-impact-motor-vehicle-crashes-driver-passenger-vehicle-and-crash-characteristics-for-fatally-and-nonfatally-injured-rear-seated-adults
#17
Chang Liu, Joyce C Pressley
BACKGROUND: Most studies of rear-seated occupants have focused on or included pediatric occupants which may not translate to adults. This study examines passenger, driver, vehicle and crash characteristics for rear-seated adult occupants involved in side crashes. METHODS: The National Automotive Sampling System General Estimates System (NASS/GES) for calendar years 2011-2014 was used with accompanying weights to examine the occupant, vehicle and crash characteristics associated with injury in rear-seated adults (n = 395,504) involved in a side crash...
December 2016: Injury Epidemiology
https://www.readbyqxmd.com/read/27743930/endogenous-and-synthetic-neuroactive-steroids-evoke-sustained-increases-in-the-efficacy-of-gabaergic-inhibition-via-a-protein-kinase%C3%A2-c-dependent-mechanism
#18
Amit Modgil, Manasa L Parakala, Michael A Ackley, James J Doherty, Stephen J Moss, Paul A Davies
The neuroactive steroid (NAS) tetrahydrodeoxycorticosterone (THDOC) increases protein kinase C (PKC) mediated phosphorylation of extrasynaptic GABAA receptor (GABAAR) subunits leading to increased surface expression of α4/β3 subunit-containing extrasynaptic GABAARs, leading to a sustained increase in GABAAR tonic current density. Whether other naturally occurring and synthetic NASs share both an allosteric and metabotropic action on GABAARs is unknown. Here, we examine the allosteric and metabotropic properties of allopregnanolone (ALLO), and synthetic NASs SGE-516 and ganaxolone...
February 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27617768/comparison-of-the-efficiency-of-rose-bengal-and-methylene-blue-as-photosensitizers-in-photodynamic-therapy-techniques-for-enterococcus-faecalis-inactivation
#19
Catia Cilene Nass Sebrão, Arandi Ginane Bezerra, Paulo Henrique Condeixa de França, Leslie Ecker Ferreira, Vania Portela Ditzel Westphalen
OBJECTIVE AND BACKGROUND: The aim of this in vitro study was to compare the efficiency of a photodynamic therapy (PDT) technique employing rose bengal (RB) and methylene blue (MB) as photosensitizers (PSs) to reduce the viability of Enterococcus faecalis, a well-known pathogen found in root canal systems. Currently, in several clinical applications, including in the field of endodontics, MB is employed in association with a red laser source for the photoinactivation of pathogenic bacteria...
January 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27592807/guideline-summary-review-an-evidence-based-clinical-guideline-for-the-diagnosis-and-treatment-of-adult-isthmic-spondylolisthesis
#20
REVIEW
D Scott Kreiner, Jamie Baisden, Daniel J Mazanec, Rakesh D Patel, Robert S Bess, Douglas Burton, Norman B Chutkan, Bernard A Cohen, Charles H Crawford, Gary Ghiselli, Amgad S Hanna, Steven W Hwang, Cumhur Kilincer, Mark E Myers, Paul Park, Karie A Rosolowski, Anil K Sharma, Christopher K Taleghani, Terry R Trammell, Andrew N Vo, Keith D Williams
BACKGROUND CONTEXT: The North American Spine Society's (NASS) Evidence-Based Clinical Guideline for the Diagnosis and Treatment of Adult Isthmic Spondylolisthesis features evidence-based recommendations for diagnosing and treating adult patients with isthmic spondylolisthesis. The guideline is intended to reflect contemporary treatment concepts for symptomatic isthmic spondylolisthesis as reflected in the highest quality clinical literature available on this subject as of June 2013. NASS' guideline on this topic is the only guideline on adult isthmic spondylolisthesis accepted in the Agency for Healthcare Research and Quality's National Guideline Clearinghouse...
December 2016: Spine Journal: Official Journal of the North American Spine Society
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