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https://www.readbyqxmd.com/read/29771038/-efficacy-of-standardized-sublingual-immunotherapy-of-allergic-asthma-with-rhinitis-in-children-between-different-age-groups
#1
S J Wu, S Chen, B Chen, L Wang, X Zeng
Objective: The aim of this study is to evaluate the efficacy of standardized sublingual immunotherapy of allergic asthma with rhinitis in children between two different age groups. Method: Retrospective analysis of 250 patients with allergic asthma and rhinitis who received SLIT treatment. According to the age divided into younger children group (aged 3-6 years, 128 patients) and older children group (aged 7-13 years, 122 patients). Evaluate the asthma daytime, nocturnal symptom, medication score, VAS score and pulmonary function FEV1, PEF% level and rhinitis symptom and medication score before and after treatment of two groups of children...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29741718/comparison-of-outcomes-following-anterior-vs-posterior-fusion-surgery-for-patients-with-degenerative-cervical-myelopathy-an-analysis-from-quality-outcomes-database
#2
Anthony L Asher, Clinton J Devin, Panagiotis Kerezoudis, Silky Chotai, Hui Nian, Frank E Harrell, Ahilan Sivaganesan, Matthew J McGirt, Kristin R Archer, Kevin T Foley, Praveen V Mummaneni, Erica F Bisson, John J Knightly, Christopher I Shaffrey, Mohamad Bydon
BACKGROUND: The choice of anterior vs posterior approach for degenerative cervical myelopathy that spans multiple segments remains controversial. OBJECTIVE: To compare the outcomes following the 2 approaches using multicenter prospectively collected data. METHODS: Quality Outcomes Database (QOD) for patients undergoing surgery for 3 to 5 level degenerative cervical myelopathy was analyzed. The anterior group (anterior cervical discectomy [ACDF] or corpectomy [ACCF] with fusion) was compared with posterior cervical fusion...
May 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29732428/minimum-ten-year-follow-up-of-spinal-stenosis-with-degenerative-spondylolisthesis-treated-with-decompression-and-dynamic-stabilization
#3
Kotryna Veresciagina, Arne Mehrkens, Stefan Schären, Bernhard Jeanneret
Background: The Dynesys system remains the most widely implanted posterior non-fusion pedicle screw system. Various study designs used in investigations with good to excellent short- and mid-term results have been reported in the current literature. However, there is a lack of information concerning long-term outcomes following treatment for spinal stenosis with degenerative spondylolisthesis. Methods: The aim of our study was twofold. Firstly, to assess whether the dynamic stabilization in situ with the Dynesys System without bone grafting provides enough stability to prevent progression of spondylolisthesis and secondarily to maintain significant clinical improvement in a long-term follow-up (FU)...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29721576/inter-laboratory-study-for-the-certification-of-trace-elements-in-seawater-certified-reference-materials-nass-7-and-cass-6
#4
Lu Yang, Kenny Nadeau, Juris Meija, Patricia Grinberg, Enea Pagliano, Francisco Ardini, Marco Grotti, Christian Schlosser, Peter Streu, Eric P Achterberg, Yoshiki Sohrin, Tomoharu Minami, Linjie Zheng, Jingfeng Wu, Gedun Chen, Michael J Ellwood, Clara Turetta, Ana Aguilar-Islas, Robert Rember, Géraldine Sarthou, Manon Tonnard, Hélène Planquette, Tomáš Matoušek, Steven Crum, Zoltán Mester
Certification of trace metals in seawater certified reference materials (CRMs) NASS-7 and CASS-6 is described. At the National Research Council Canada (NRC), column separation was performed to remove the seawater matrix prior to the determination of Cd, Cr, Cu, Fe, Pb, Mn, Mo, Ni, U, V, and Zn, whereas As was directly measured in 10-fold diluted seawater samples, and B was directly measured in 200-fold diluted seawater samples. High-resolution inductively coupled plasma mass spectrometry (HR-ICPMS) was used for elemental analyses, with double isotope dilution for the accurate determination of B, Cd, Cr, Cu, Fe, Pb, Mo, Ni, U, and Zn in seawater NASS-7 and CASS-6, and standard addition calibration for As, Co, Mn, and V...
May 2, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29709552/how-social-media-training-and-demographics-influence-online-reviews-across-three-leading-review-websites-for-spine-surgeons
#5
Chester J Donnally, Deborah J Li, James A Maguire, Eric S Roth, Grant P Barker, Johnathon R McCormick, Augustus J Rush, Nathan H Lebwohl
BACKGROUND CONTEXT: The future of healthcare is consumer driven with a focus on outcome metrics and patient feedback. Physician review websites have grown in popularity and are guiding patients to certain healthcare providers, for better or worse. No prior study has specifically evaluated internet reviews of spine surgeons, determined if social media correlates with patient reviews, or evaluated Google as a physician review website. PURPOSE: To evaluate patient satisfaction scores for spine surgeons in Florida using leading physician ratings websites...
April 27, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29627710/crash-sequence-based-risk-matrix-for-motorcycle-crashes
#6
Kun-Feng Wu, Lekshmi Sasidharan, Craig P Thor, Sheng-Yin Chen
Considerable research has been conducted related to motorcycle and other powered-two-wheeler (PTW) crashes; however, it always has been controversial among practitioners concerning with types of crashes should be first targeted and how to prioritize resources for the implementation of mitigating actions. Therefore, there is a need to identify types of motorcycle crashes that constitute the greatest safety risk to riders - most frequent and most severe crashes. This pilot study seeks exhibit the efficacy of a new approach for prioritizing PTW crash causation sequences as they relate to injury severity to better inform the application of mitigating countermeasures...
April 5, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29584509/improvement-of-injury-severity-prediction-isp-of-aacn-during-on-site-triage-using-vehicle-deformation-pattern-for-car-to-car-c2c-side-impacts
#7
Chinmoy Pal, Shigeru Hirayama, Sangolla Narahari, Manoharan Jeyabharath, Gopinath Prakash, Vimalathithan Kulothungan, John Combest
OBJECTIVE: The Advanced Automatic Crash Notification (AACN) system needs to predict injury accurately, to provide appropriate treatment for seriously injured occupants involved in motor vehicle crashes. This study investigates the possibility of improving the accuracy of the AACN system, using vehicle deformation parameters in car-to-car (C2C) side impacts. METHODS: This study was based on car-to-car (C2C) crash data from NASS-CDS, CY 2004-2014. Variables from Kononen's algorithm (published in 2011) were used to build a "base model" for this study...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584505/a-preliminary-study-of-human-model-head-and-neck-response-to-frontal-loading-in-nontraditional-occupant-seating-configurations
#8
F S Gayzik, B Koya, M L Davis
OBJECTIVE: Computational human body models (HBMs) are nominally omnidirectional surrogates given their structural basis in human anatomy. As a result, such models are well suited for studies related to occupant safety in anticipated highly automated vehicles (HAVs). We utilize a well-validated HBM to study the head and neck kinematics in simulations of nontraditional occupant seating configurations. METHODS: The GHBMC M50-O v. 4.4 HBM was gravity settled into a generic seat buck and situated in a seated posture...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584488/functional-outcomes-of-thoracic-injuries-in-pediatric-and-adult-occupants
#9
Ashley A Weaver, Samantha L Schoell, Jennifer W Talton, Ryan T Barnard, Joel D Stitzel, Mark R Zonfrillo
OBJECTIVE: To develop a disability metric for motor vehicle crash (MVC) thoracic injuries and compare functional outcomes between pediatric and adult populations. METHODS: Disability risk (DR) was quantified using Functional Independence Measure (FIM) scores within the National Trauma Data Bank (NTDB) for the top 95% most frequently occurring AIS 2, 3, 4, and 5 thoracic injuries in NASS-CDS 2000-2011. The NTDB contains a truncated form of the FIM score, including three items (self-feed, locomotion, and verbal expression), each graded from full functional dependence to full functional independence...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29553802/severe-injury-in-multiple-impacts-analysis-of-1997-2015-nass-cds
#10
David C Viano, Chantal S Parenteau
PURPOSE: This is a descriptive study of the incidence and risk for severe injury in a single impact and multi-impact crashes by belt use and crash type using NASS-CDS. METHODS: 1997-2015 NASS-CDS was used to determine the distribution of crashes by the number of impacts and severe injury (MAIS 4+F) to >15 year old non-ejected drivers by seatbelt use in 1997+ MY vehicles. It compares the risk for severe injury in a single impact and in crashes involving two, three or four+ impacts in the collision with focus on a frontal crash followed by other impacts...
March 19, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29529295/services-for-spondyloarthitis-a-survey-of-patients-and-rheumatologists
#11
Mohammad H Derakhshan, Himanshu Pathak, Debbie Cook, Sally Dickinson, Stefan Siebert, Karl Gaffney
Objectives: There have been significant advances in axial spondyloarthritis (axSpA), with implications for service delivery. We evaluated the state of axSpA rheumatology services and how people with axSpA perceive their care. Methods: An online patient survey was emailed to all members of the National Ankylosing Spondylitis Society and advertised widely via social media. Separately, a Web-based questionnaire about axSpA services was sent to rheumatologists at all 172 acute hospital trusts in the UK...
February 23, 2018: Rheumatology
https://www.readbyqxmd.com/read/29501200/ultrasensitive-hexavalent-chromium-determination-at-bismuth-film-electrode-prepared-with-mediator
#12
Katarzyna Tyszczuk-Rotko, Karolina Madejska, Katarzyna Domańska
A bismuth film electrode prepared in situ with a reversibly deposited mediator (Zn) applied for ultrasensitive determination of Cr(VI) using differential pulse catalytic adsorptive stripping voltammetry is presented. The optimization of experimental conditions such as composition of the supporting electrolyte, potential and time of bismuth film formation as well as analyte accumulation, and DP mode parameters is reported. For 180 s accumulation time, very low limits of detection and quantification of Cr(VI) were obtained, with 5...
May 15, 2018: Talanta
https://www.readbyqxmd.com/read/29394443/application-of-extreme-value-theory-to-crash-data-analysis
#13
Lan Xu, Guy Nusholtz
A parametric model obtained by fitting a set of data to a function generally uses a procedure such as maximum likelihood or least squares. In general this will generate the best estimate for the distribution of the data overall but will not necessarily generate a reasonable estimation for the tail of the distribution unless the function fitted resembles the underlying distribution function. A distribution function can represent an estimate that is significantly different from the actual tail data, while the bulk of the data is reasonably represented by the central part of the fitted distribution...
November 2017: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/29360404/cross-correlation-between-the-controlled-collision-environment-and-real-world-motor-vehicle-collisions-evaluating-the-protection-of-the-thoracic-side-airbag
#14
Luke Gaylor, Mirko Junge, Sylvester Abanteriba
OBJECTIVE: Thoracic side airbags (tSABs) were integrated into the vehicle fleet to attenuate and distribute forces on the occupant's chest and abdomen, dissipate the impact energy, and move the occupant away from the intruding structure, all of which reduce the risk of injury. This research piece investigates and evaluates the safety performance of the airbag unit by cross-correlating data from a controlled collision environment with field data. METHOD: We focus exclusively on vehicle-vehicle lateral impacts from the NHTSA's Vehicle Crash Test Database and NASS-CDS database, which are replicated in the controlled environment by the (crabbed) barrier impact...
January 23, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29349097/universal-method-for-the-purification-of-recombinant-aav-vectors-of-differing-serotypes
#15
Shelley A Nass, Maryellen A Mattingly, Denise A Woodcock, Brenda L Burnham, Jeffrey A Ardinger, Shayla E Osmond, Amy M Frederick, Abraham Scaria, Seng H Cheng, Catherine R O'Riordan
The generation of clinical good manufacturing practices (GMP)-grade adeno-associated virus (AAV) vectors requires purification strategies that support the generation of vectors of high purity, and that exhibit a good safety and efficacy profile. To date, most reported purification schemas are serotype dependent, requiring method development for each AAV gene therapy product. Here, we describe a platform purification process that is compatible with the purification of multiple AAV serotypes. The method generates vector preparations of high purity that are enriched for capsids with full vector genomes, and that minimizes the fractional content of empty capsids...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29329787/outcomes-of-multisegmental-transforaminal-enlarged-decompression-plus-posterior-pedicle-screw-fixation-for-multilevel-lumbar-spinal-canal-stenosis-associated-with-lumbar-instability
#16
Chao Sun, Wei Ji Tian, Hui Xin Liu, Ping Guo Guan
PURPOSE: The aim of this study was to evaluate the clinical and radiologic results of multisegmental transforaminal enlarged decompression (TED) plus posterior pedicle screw fixation in the treatment of multilevel lumbar spinal canal stenosis (LSCS) with lumbar instability (MLSCSI). METHODS: 113 patients with MLSCSI underwent surgery were recruited in this study. All patients were suffering from symptoms typical of degenerative LSCS and treated with either TED plus fusion (TEDF group) or conventional laminectomy plus fusion (CLF group)...
February 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29322966/the-influence-of-adjunctive-caudal-epidural-steroid-injection-on-the-therapeutic-effect-of-transforaminal-epidural-steroid-injection
#17
Atilla Kircelli, Tufan Cansever, Cem Yılmaz
BACKGROUND: Epidural steroid injection is widely used to treat the short and long-term symptoms of low back and radicular pain. To the best of our knowledge, the influence of transforaminal epidural steroid injection (TFSI) combined with caudal epidural steroid injection (CESI) on pain intensity, patient satisfaction, and quality of life in lumbar radiculopathy has not been examined. AIM: To evaluate the short and long-term efficacy of TFSI, and TFSI combined with CESI (TFSI + CESI) in patients with lumbar radiculopathy...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29290130/women-fare-best-following-surgery-for-degenerative-lumbar-spondylolisthesis-a-comparison-of-the-most-and-least-satisfied-patients-utilizing-data-from-the-quality-outcomes-database
#18
Andrew K Chan, Erica F Bisson, Mohamad Bydon, Steven D Glassman, Kevin T Foley, Eric A Potts, Christopher I Shaffrey, Mark E Shaffrey, Domagoj Coric, John J Knightly, Paul Park, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Panagiotis Kerezoudis, Silky Chotai, Anthony M DiGiorgio, Alvin Y Chan, Regis W Haid, Praveen V Mummaneni
OBJECTIVE The American Association of Neurological Surgeons launched the Quality Outcomes Database (QOD), a prospective longitudinal registry that includes demographic, clinical, and patient-reported outcome (PRO) data, to measure the safety and quality of neurosurgical procedures, including spinal surgery. Differing results from recent randomized controlled trials have established a need to clarify the groups that would most benefit from surgery for degenerative lumbar spondylolisthesis. In the present study, the authors compared patients who were the most and the least satisfied following surgery for degenerative lumbar spondylolisthesis...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29289303/determination-of-ultra-trace-level-of-232-th-in-seawater-by-icp-sfms-after-matrix-separation-and-preconcentration
#19
Irena Wysocka, Emilia Vassileva
This article describes the development and validation of an analytical procedure for the matrix separation, preconcentration and determination of sub-ng kg-1 levels232 Th in a small volume (20 mL) of seawater samples. The matrix separation and Th preconcentration was carried out using a commercially available ion-chelation system seaFAST-pico. The acidified to pH < 2 seawater samples were mixed on-line with the ammonium acetate buffer (pH of 6.0 ± 0.2) before loading on the column containing resin with iminodiacetic and ethylenediaminetriacetic functional groups...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29287819/adult-spinal-deformity-knowledge-in-orthopedic-spine-surgeons-impact-of-fellowship-training-experience-and-practice-characteristics
#20
Zachary J Grabel, Robert A Hart, Aaron P Clark, Sara Heejung Park, Christopher I Shaffrey, Justin K Scheer, Justin S Smith, Michael P Kelly, J Mason DePasse, Munish C Gupta, Christopher P Ames, Alan H Daniels
STUDY DESIGN: Survey study. OBJECTIVE: The purpose of this paper was to assess the level of adult spine deformity (ASD) knowledge among orthopedic spine surgeons and identify areas for improvement in spine surgery training. SUMMARY OF BACKGROUND DATA: ASD is increasingly encountered in spine surgery practice. While ASD knowledge among neurosurgeons has been evaluated, ASD knowledge among orthopedic spine surgeons has not previously been reported...
January 2018: Spine Deformity
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