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https://www.readbyqxmd.com/read/28645961/cognitive-screening-and-behavioural-observation-of-functional-ability-in-patients-with-multiple-episode-schizophrenia-an-exploratory-study
#1
Eva Norlin Bagge, Eva Esbjörnsson, Katharina S Sunnerhagen
OBJECTIVES: To evaluate the usability of a neuropsychological screening instrument and two observation scales of everyday behaviour to describe cognitive and functional capacity of patients with multiepisode schizophrenia and considerable care needs, who frequently refuse to participate in cognitive testing or performance-based functional measurement. SETTING: One psychiatric unit specialised in severe mental illness at the Sahlgrenska University Hospital, Gothenburg, Sweden...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28627392/the-great-barrier-belief-the-blood-brain-barrier-and-considerations-for-juvenile-toxicity-studies
#2
REVIEW
Georg Schmitt, Neil Parrott, Eric Prinssen, Paul Barrow
Juvenile animal studies can be warranted to support the development of pediatric medicines. Drugs acting on the CNS or those which penetrate into the brain merit particular attention. The blood-brain barrier is functionally mature at birth, but undergoes functional postnatal modulation to provide a suitable microenvironment for the developing brain. In the past, dosing in rat juvenile studies has often commenced at 4 or 7days of age. However, rodents are very neurologically immature at birth compared with humans...
June 13, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28621622/glossopharyngeal-neuralgia-treated-by-gamma-knife-radiosurgery-safety-and-efficacy-through-long-term-follow-up
#3
Benjamin Pommier, Gustavo Touzet, Christian Lucas, Maximilien Vermandel, Serge Blond, Nicolas Reyns
OBJECTIVE Glossopharyngeal neuralgia (GPN) is a rare and disabling condition. Just as for trigeminal neuralgia, Gamma Knife radiosurgery (GKRS) is increasingly proposed as a therapeutic option for GPN. The purpose of this study was to assess long-term safety and efficacy of GKRS for this indication. METHODS From 2007 to 2015, 9 patients (4 male and 5 female) underwent a total of 10 GKRS procedures. All of the patients presented with GPN that was refractory to all medical treatment, and all had a long history of pain...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28607821/frameless-image-guided-radiosurgery-for-trigeminal-neuralgia
#4
Lisa B E Shields, Todd S Shanks, Andrew J Shearer, Lauren A Shelton, Brent J Shelton, Jonathan Howe, James M Coons, Brian Plato, Aaron C Spalding
BACKGROUND: Frameless image-guided radiosurgery (IGRS) is a safe and effective noninvasive treatment for trigeminal neuralgia (TN). This study evaluates the use of frameless IGRS to treat patients with refractory TN. METHODS: We reviewed the records of 20 patients diagnosed with TN who underwent frameless IGRS treatments between March 2012 and December 2013. Facial pain was graded using the Barrow Neurological Institute (BNI) scoring system. The initial setup uncertainty from simulation to treatment and the patient intrafraction uncertainty were measured...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28598279/a-novel-score-to-predict-shunt-dependency-after-aneurysmal-subarachnoid-hemorrhage
#5
Dominik Diesing, Stefan Wolf, Jenny Sommerfeld, Asita Sarrafzadeh, Peter Vajkoczy, Nora F Dengler
OBJECTIVE Feasible clinical scores for predicting shunt-dependent hydrocephalus (SDHC) after aneurysmal subarachnoid hemorrhage (aSAH) are scarce. The chronic hydrocephalus ensuing from SAH score (CHESS) was introduced in 2015 and has a high predictive value for SDHC. Although this score is easy to calculate, several early clinical and radiological factors are required. The authors designed the retrospective analysis described here for external CHESS validation and determination of predictive values for the radiographic Barrow Neurological Institute (BNI) scoring system and a new simplified combined scoring system...
June 9, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28565979/flow-diversion-of-tandem-cerebral-aneurysms-a-multi-institutional-retrospective-study
#6
Al-Wala Awad, Karam Moon, Nam Yoon, Marcus D Mazur, M Yashar S Kalani, Philipp Taussky, Cameron G McDougall, Felipe C Albuquerque, Min S Park
OBJECTIVE Flow diversion has proven to be an efficacious means of treating cerebral aneurysms that are refractory to other therapeutic means. Patients with tandem aneurysms treated with flow diversion have been included in larger, previously reported series; however, there are no dedicated reports on using this technique during a single session to treat this unique subset of patients. Therefore, the authors analyzed the outcomes of patients who had undergone single-session flow diversion for the treatment of tandem aneurysms...
June 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28552148/arteriovenous-malformations-epidemiology-clinical-presentation-and-diagnostic-evaluation
#7
Joshua W Osbun, Matthew R Reynolds, Daniel L Barrow
Brain arteriovenous malformations (AVMs) represent an uncommon disease of the central nervous system characterized by an arteriovenous shunt in which one or multiple arterial pedicles feed into a vascular nidus, creating early drainage into a venous outflow channel. These lesions are considered to be congenital and can come to clinical attention in a variety of ways such as seizure, intracranial hemorrhage, chronic headache or progressive neurological deficit. We focus on the epidemiology, clinical presentation and diagnostic evaluation in this chapter...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28549754/predictive-value-of-magnetic-resonance-for-identifying-neurovascular-compressions-in-trigeminal-neuralgia
#8
F Ruiz-Juretschke, J G Guzmán-de-Villoria, R García-Leal, J R Sañudo
INTRODUCTION: Microvascular decompression (MVD) is accepted as the only aetiological surgical treatment for refractory classic trigeminal neuralgia (TN). There is therefore increasing interest in establishing the diagnostic and prognostic value of identifying neurovascular compressions (NVC) using preoperative high-resolution three-dimensional magnetic resonance (MRI) in patients with classic TN who are candidates for surgery. METHODS: This observational study includes a series of 74 consecutive patients with classic TN treated with MVD...
May 23, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28548599/an-extent-of-resection-threshold-for-seizure-freedom-in-patients-with-low-grade-gliomas
#9
David S Xu, Al-Wala Awad, Chad Mehalechko, Jeffrey R Wilson, Lynn S Ashby, Stephen W Coons, Nader Sanai
OBJECTIVE Seizures are the most common presenting symptom of newly diagnosed WHO Grade II gliomas (low-grade glioma [LGG]) and significantly impair quality of life. Although gross-total resection of LGG is associated with better seizure control, it remains unclear whether an extent of resection (EOR) "threshold" exists for long-term seizure control. Specifically, what proportion of FLAIR-positive tissue in patients with newly diagnosed LGG must be removed to achieve Engel Class I seizure freedom? To clarify the EOR threshold for long-term seizure control, the authors analyzed data from a consecutive series of patients with newly diagnosed LGG who presented with seizures and subsequently underwent microsurgical resection...
May 26, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28532912/gamma-knife-radiosurgery-for-idiopathic-trigeminal-neuralgia-does-the-status-of-offending-vessels-influence-on-pain-control-or-side-effects
#10
Hyun Ho Jung, Chang Kyu Park, Na Young Jung, Minsoo Kim, Won Seok Chang, Jin Woo Chang
OBJECTIVE: To determine pain control and side effects after gamma knife radiosurgery (GKRS) for classical idiopathic trigeminal neuralgia (TN) with or without neurovascular compression (NVC). METHODS: This study included 47 patients with type 1 idiopathic TN and Barrow Neurological Institute (BNI) pain class IV or V that were treated with GKRS, with maximal dose of 85 Gy targeting root entry zone, as a first-treatment modality between January 2005 and March 2015...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28524797/the-relationship-of-dose-to-nerve-volume-in-predicting-pain-recurrence-after-stereotactic-radiosurgery-in-trigeminal-neuralgia
#11
Amparo Wolf, Amy Tyburczy, Jason Chao Ye, Girish Fatterpekar, Joshua S Silverman, Douglas Kondziolka
OBJECTIVE Approximately 75%-92% of patients with trigeminal neuralgia (TN) achieve pain relief after Gamma Knife surgery (GKS), although a proportion of these patients will experience recurrence of their pain. To evaluate the reasons for durability or recurrence, this study determined the impact of trigeminal nerve length and volume, the nerve dose-volume relationship, and the presence of neurovascular compression (NVC) on pain outcomes after GKS for TN. METHODS Fifty-eight patients with 60 symptomatic nerves underwent GKS for TN between 2013 and 2015, including 15 symptomatic nerves secondary to multiple sclerosis (MS)...
May 19, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28511576/performance-of-a-brazilian-sample-on-the-portuguese-translation-of-the-bni-screen-for-higher-cerebral-functions
#12
George P Prigatano, Lígia M N Souza, Lucia W Braga
INTRODUCTION: The Barrow Neurological Institute (BNI) Screen for Higher Cerebral Functions (BNIS) has been translated into several languages and found useful in evaluating multiple domains of cognitive and affective dysfunction, particularly in neuro-rehabilitation settings. Normative data from countries with high literacy rates have reported strikingly similar mean level of performance scores on this test, with age typically correlating higher with total score performance than education...
May 17, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28502974/efficacy-and-prognostic-value-of-partial-sensory-rhizotomy-and-microvascular-decompression-for-primary-trigeminal-neuralgia-a-comparative-study
#13
Jian Gao, Yao Fu, Shi-Kun Guo, Bing Li, Zhong-Xin Xu
BACKGROUND This study aimed to compare the efficacy and prognostic value of partial sensory rhizotomy (PSR) and microvascular decompression (MVD) for primary trigeminal neuralgia (PTN). MATERIAL AND METHODS From June 2010 to June 2012, 117 patients with PTN were recruited for the study, of which 52 cases were treated with MVD (the MVD group) and 65 cases were treated with PSR (the PSR group). Visual Analog Scoring (VAS) was performed at 1 and 2 weeks, and at 1, 3, and 6 month after surgery. The overall response rate (ORR) was determined 1 month after surgery...
May 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28501876/stereotactic-radiosurgery-as-initial-surgical-management-for-elderly-patients-with-trigeminal-neuralgia
#14
Jonathan Cohen, Seyed H Mousavi, Amir H Faraji, Berkcan Akpinar, Edward A Monaco, John C Flickinger, Ajay Niranjan, L Dade Lunsford
BACKGROUND: Management of older patients with medically refractory trigeminal neuralgia (TN) is yet a matter of debate. OBJECTIVE: We sought to determine the benefit of stereotactic radiosurgery (SRS) as the sole surgical management in older patients (≥70 years). METHODS: One hundred and twenty-seven patients (≥70 years) with typical TN underwent SRS as initial surgical management. The median maximum dose for the first procedure was 80 Gy...
May 13, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28495948/introduction-of-a-dedicated-emergency-department-mr-imaging-scanner-at-the-barrow-neurological-institute
#15
M Buller, J P Karis
Use of advanced imaging in the emergency department has been increasing in the United States during the past 2 decades. This trend has been most notable in CT, which has increased concern over the effects of increasing levels of medical ionizing radiation. MR imaging offers a safe, nonionizing alternative to CT and is diagnostically superior in many neurologic conditions encountered in the emergency department. Herein, we describe the process of developing and installing a dedicated MR imaging scanner in the Neuroscience Emergency Department at the Barrow Neurological Institute and its effects on neuroradiology and the emergency department in general...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28454993/frameless-stereotactic-radiosurgery-for-the-treatment-of-multiple-sclerosis-related-trigeminal-neuralgia
#16
Alfredo Conti, Antonio Pontoriero, Giuseppe Iatì, Felice Esposito, Enrico Nastro Siniscalchi, Salvatore Crimi, Sergio Vinci, Anna Brogna, Francesco De Ponte, Antonino Germanò, Stefano Pergolizzi, Francesco Tomasello
BACKGROUND: Trigeminal neuralgia (TN) affects 7% of patients with multiple sclerosis (MS). In such patients, TN is difficult to manage either pharmacologically and surgically. Radiosurgical rhizotomy is an effective treatment option. The non-isocentric geometry of radiation beams of CyberKnife introduces new concepts in the treatment of TN. Its efficacy for MS-related TN has not yet been demonstrated. METHODS: Twenty-seven patients with refractory TN and MS were treated...
April 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28452614/outcomes-after-hemispherectomy-in-adult-patients-with-intractable-epilepsy-institutional-experience-and-systematic-review-of-the-literature
#17
Courtney M Schusse, Kris Smith, Cornelia Drees
OBJECTIVE Hemispherectomy is a surgical technique that is established as a standard treatment in appropriately selected patients with drug-resistant epilepsy. It has proven to be successful in pediatric patients with unilateral hemispheric lesions but is underutilized in adults. This study retrospectively evaluated the clinical outcomes after hemispherectomy in adult patients with refractory epilepsy. METHODS This study examined 6 cases of hemispherectomy in adult patients at Barrow Neurological Institute. In addition, all case series of hemispherectomy in adult patients were identified through a literature review using MEDLINE and PubMed...
April 28, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28391972/neuroaxonal-dystrophy-in-a-flock-of-pied-imperial-pigeons-ducula-bicolor
#18
M Barrows, R Killick, C Day, R Saunders, K Baiker, L Ressel, D Denk
Five juvenile pied imperial pigeons (Ducula bicolor) presented with neurological signs including torticollis, ataxia and poor flying ability. All were humanely destroyed and submitted for post-mortem examination. Microscopically, the most significant findings were in the brain and spinal cord. Spheroid formation was evident within the medulla, pons, diencephalon, cortical grey and subcortical white matter, spinal cord white and grey matter and the granular and molecular cell layers of the cerebellum. There was no evidence of associated inflammation...
April 6, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28374616/treatment-of-barrow-type-b-carotid-cavernous-fistulas-with-flow-diverter-stent-pipeline
#19
Carlos Castaño, Sebastián Remollo, Rosa García-Sort, Carlos Domínguez, Mikel Terceño
Background Carotid cavernous fistulas (CCFs) Barrow type 'B' are dural shunts between the meningeal branches of the internal carotid artery and the cavernous sinus. The symptoms include vision deterioration, ophthalmoplegia with diplopia, exophthalmos, conjunctival injection, chemosis, ocular bruit, seizures, or neurological deficit. Endovascular treatment remains the gold standard for treatment through the transvenous or transarterial routes. The transvenous approaches have been proved to be the first option...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28336479/radiosurgical-target-distance-from-the-root-entry-zone-in-the-treatment-of-trigeminal-neuralgia
#20
Justin Sharim, Wei-Lun Lo, Won Kim, Srinivas Chivukula, Stephen Tenn, Tania Kaprealian, Nader Pouratian
PURPOSE: Stereotactic radiosurgery (SRS) provides a noninvasive treatment modality for patients with medically refractory trigeminal neuralgia. The root entry zone (REZ) has been proposed to be an ideal stereotactic target because it is partially composed of centrally produced myelin, conferring a theoretical increased sensitivity to irradiation as well as increased susceptibility to neurovascular conflict, making it the site in which nociceptive signals likely arise. The aim of this study is to determine if there is a statistically and clinically significant difference in pain relief or facial hypesthesia following SRS based on distance of the stereotactic isocenter from REZ...
December 23, 2016: Practical Radiation Oncology
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