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https://www.readbyqxmd.com/read/29174233/effectiveness-of-gamma-knife-radiosurgery-in-improving-psychophysical-performance-and-patient-s-quality-of-life-in-idiopathic-trigeminal-neuralgia
#1
Filippo Gagliardi, Alfio Spina, Michele Bailo, Nicola Boari, Andrea Cavalli, Alberto Franzin, Arianna Fava, Antonella Del Vecchio, Angelo Bolognesi, Pietro Mortini
OBJECTIVE: To assess effectiveness of Gamma Knife Radiosurgery (GKRS) in improving quality of life (QoL) in patients with idiopathic trigeminal neuralgia (TN). METHODS: Between January 2001 and October 2013, 166 patients with medically resistant TN were treated at our Institution with GKRS. Patients were divided into two groups: TTN (typical trigeminal neuralgia) and ATN (atypical trigeminal neuralgia) patients. All patients underwent clinical evaluation using Marseille, BNI (Barrow Neurological Institute) pain and numbness scores, moreover they completed the Short Form (36) Health Survey (SF-36), ADL (Activity Daily Living) and EGFP (Excellent Good Fair Poor) questionnaires, and underwent psychological and neurological examination...
November 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29170837/post-traumatic-carotid-cavernous-fistula-in-a-pediatric-patient-a-case-based-literature-review
#2
Barbara Albuquerque Morais, Vitor Nagai Yamaki, Jose Guilherme Mendes Pereira Caldas, Wellingson Silva Paiva, Hamilton Matushita, Manoel Jacobsen Teixeira
BACKGROUND: Carotid-cavernous fistula (CCF) is a shunt between the carotid artery and the cavernous sinus. Traumatic CCFs are diagnosed in 0.2% of head traumas being only 4.6% of the pediatric population. Classified by Barrow in 1985, type A CCF is the most frequent, occurring in 75% of cases. Type A is characterized by direct and high-flow CCF that generally can occur as a result of traumatic injury or rupture of an intracavernous aneurysm. CASE PRESENTATION: The subject was an 8-year-old boy with penetrating trauma to his left eye...
November 23, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29074316/outcome-of-gamma-knife-radiosurgery-for-trigeminal-neuralgia-associated-with-neurovascular-compression
#3
Cheng-Siu Chang, Cheng-Wei Huang, His-Hsien Chou, Long-Yau Lin, Chuan-Fu Huang
We reviewed 130 patients from 1999 to 2012 to evaluate whether neurovascular compression (NVC) has prognostic value for pain relief in idiopathic trigeminal neuralgia (TN) treated by Gamma Knife radiosurgery (GKRS). Patients were assigned to one of the following groups based on NVC identified by MRI: no NVC, small vessel NVC, and large vessel (defined as part of the vertebrobasilar arterial system) NVC. Follow-up ranged from 4 to 14years. Primary outcome was pain graded by the Barrow Neurological Institute (BNI) pain scale...
October 23, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29038085/outcomes-of-two-isocenter-gamma-knife-radiosurgery-for-typical-trigeminal-neuralgia-patients-pain-response-and-quality-of-life
#4
Zhao Hongyang, Shen Yin, Yao Dongxiao, Xiong Nanxiang, Ahmed Abdelmaksoud, Wang Haijun
OBJECTIVE: To evaluate the effectiveness and safety of two isocenter GKS by reviewing TN patients of last ten years. METHODS: A total of 247 patients were followed up and the Barrow Neurological Institute (BNI) scale was employed to evaluate pain degree. Patients' age, gender, pain duration and location, pre/post-operative BNI score, time to initial pain relief, recurrence time and complications were documented and analyzed. RESULTS: Patients who underwent a two isocenter GKS could get an earlier initial pain relief...
October 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29030464/computed-tomography-interobserver-agreement-in-the-assessment-of-aneurysmal-subarachnoid-hemorrhage-and-predictors-for-clinical-outcome
#5
Peter Y M Woo, Teresa P K Tse, Robert S K Chan, Lianne N Y Leung, Stephanie K K Liu, Andrew Y T Leung, Hoi-Tung Wong, Kwong-Yau Chan
BACKGROUND: The severity of aneurysmal subarachnoid hemorrhage (SAH) is often assessed by the clinical state of the patient on presentation, but radiological evaluation of the extent of hemorrhage has rarely been examined in the literature. Several CT scan based grading systems exist yet only a few studies have investigated interobserver agreement. We evaluated five radiological grading systems and assessed their clinical value for early prognostication. METHODOLOGY: This was a retrospective study of patients diagnosed with aneurysmal SAH with a CT scan performed within 72 hours of symptom onset...
November 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28961605/radial-extracorporeal-shock-wave-therapy-in-an-individual-with-primary-trigeminal-neuralgia-a-case-report-and-literature-review
#6
Dai Zhang, Ying Meng, Hong Hai, Xiao Tong Yu, Yue Wen Ma
A patient with primary trigeminal neuralgia exhibited pain relief without medication after radial extracorporeal shock wave therapy. The 52-yr-old woman had a 3-yr history of primary trigeminal neuralgia, involving the right maxillary division (V2) and the mandibular division (V3). She became refractory to carbamazepine and exhibited hepatic dysfunction. She hence received 3000 to 6000 impulses of craniofacial radial extracorporeal shock wave therapy to the region centered on the surface projection of the trigeminal ganglion and pain areas at 10 Hz; the intensity ranged from 1...
September 28, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28953684/long-term-outcome-of-percutaneous-balloon-compression-for-trigeminal-neuralgia-patients-elder-than-80-years-a-strobe-compliant-article
#7
Xiang Ying, Hao Wang, Shanghua Deng, Yinggao Chen, Jie Zhang, Wenhua Yu
This article evaluates the long-term outcome of percutaneous balloon compression (PBC) for trigeminal neuralgia (TN) patients elder than 80 years. A total of 138 elderly patients aged above 80 years with primary TN, who were admitted to Neurosurgery Department, Hangzhou First People's Hospital from January 2007 to December 2011 for PBC treatment, were retrospectively analyzed in this study. The postoperative cure rate of immediate pain was 98.6% (Barrow Neurological Institute [BNI] classes I, II); according to the follow-up, the pain cure rates at 1, 2, 3, 4, and 5 years after surgery were 93...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28940973/prediction-of-cerebral-infarction-and-patient-outcome-in-aneurysmal-subarachnoid-hemorrhage-comparison-of-new-and-established-radiographic-clinical-and-combined-scores
#8
Nora F Dengler, Jenny Sommerfeld, Dominik Diesing, Peter Vajkoczy, Stefan Wolf
BACKGROUND: There are numerous grading scales to describe the severity of aneurysmal subarachnoid hemorrhage (aSAH) and to predict outcome. Historically, outcome measures are heterogenous and comparability of grading scales is therefore limited. We designed this study to compare radiographic, clinical and combined grading systems in aSAH. METHODS: Data of 423 consecutive patients with aSAH were analyzed. Modified Fisher, Barrow Neurological Institute (BNI), Hunt and Hess, World Federations of Neurosurgeons (WFNS), VASOGRADE and HAIR scores were calculated from clinical and radiographic data or the combination of both...
September 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28927915/stereotactic-radiosurgery-for-type-1-versus-type-2-trigeminal-neuralgias
#9
Ching-Jen Chen, Gabriella Paisan, Thomas J Buell, Kristen Knapp, Dale Ding, Zhiyuan Xu, Daniel M Raper, Davis G Taylor, Robert F Dallapiazza, Cheng-Chia Lee, Jason P Sheehan
INTRODUCTION: It remains unclear whether if stereotactic radiosurgery (SRS) offers the same benefit for patients with type 2 trigeminal neuralgia (TN2) as for those with type 1 trigeminal neuralgia (TN1). The objective of this study is to compare the outcomes of patients with TN1 and TN2 following SRS. METHODS: SRS outcomes of trigeminal neuralgia patients treated at a single center from 1994 to 2016 were analyzed. Patients with TN1 were matched to those with TN2 in a 1:1 ratio based on sex, age, pre-treatment Barrow Neurological Institute (BNI) pain score, prior treatment, prior facial numbness, and maximum dose...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28905114/long-term-outcomes-of-microvascular-decompression-and-gamma-knife-surgery-for-trigeminal-neuralgia-a-retrospective-comparison-study
#10
Takuro Inoue, Hisao Hirai, Ayako Shima, Fumio Suzuki, Masayuki Yamaji, Takanori Fukushima, Masayuki Matsuda
BACKGROUND: There is still no clear guideline for surgical treatment for patients with medically refractory trigeminal neuralgia (TN). When it comes to which surgical treatment to choose, microvascular decompression (MVD) or Gamma Knife surgery (GKS), we should know the long-term outcome of each treatment. METHODS: We analyzed 179 patients undergoing MVD and 52 patients undergoing GKS followed for 1 year or longer. We evaluated the patient's neurological status including pain relief, complications and recurrence...
November 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28751459/pten-loss-increases-the-connectivity-of-fast-synaptic-motifs-and-functional-connectivity-in-a-developing-hippocampal-network
#11
Caitlynn M Barrows, Matthew P McCabe, Hongmei Chen, John W Swann, Matthew C Weston
Changes in synaptic strength and connectivity are thought to be a major mechanism through which many gene variants cause neurological disease. Hyperactivation of the PI3K-mTOR signaling network, via loss of function of repressors such as PTEN, causes epilepsy in humans and animal models, and altered mTOR signaling may contribute to a broad range of neurological diseases. Changes in synaptic transmission have been reported in animal models of PTEN loss; however, the full extent of these changes, and their effect on network function, is still unknown...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28721891/stereotactic-radiosurgery-for-trigeminal-neuralgia-improves-patient-reported-quality-of-life-and-reduces-depression
#12
Rupesh Kotecha, Jacob A Miller, Sujith Modugula, Gene H Barnett, Erin S Murphy, Chandana A Reddy, John H Suh, Gennady Neyman, Andre Machado, Sean Nagel, Samuel T Chao
PURPOSE: To characterize quality-of-life (QOL) outcomes after stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN). METHODS AND MATERIALS: The EuroQOL 5 Dimensions (EQ-5D) and Patient Health Questionnaire 9 (PHQ-9) were prospectively collected before and after SRS for 50 patients with TN. Pain response and treatment-related facial numbness were classified by Barrow Neurological Institute (BNI) scales. Differences in pooled QOL outcomes were tested with paired t tests and sign tests...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721330/truebeam-radiosurgery-for-the-treatment-of-trigeminal-neuralgia-preliminary-results-at-a-single-institution
#13
Mena G Kerolus, Neilayan Sen, Sonal Mayekar, Alistar Templeton, Julius Turian, Aidnag Diaz, Lorenzo Munoz, Richard W Byrne, Sepehr Sani
INTRODUCTION: Radiosurgery is now an established method of satisfactory pain control in patients with trigeminal neuralgia (TN). The Varian Truebeam STx (Varian Medical Systems, Palo Alto, CA) linear accelerator (LINAC) system is an arc-based, frameless stereotactic radiosurgery system used for the treatment of TN. To our knowledge, there has been only one published series of patient histories that documents the use of a frameless LINAC system for the treatment of TN. We describe the treatment parameters, patient outcomes, and complications associated with the treatment of TN...
June 16, 2017: Curēus
https://www.readbyqxmd.com/read/28686948/posterior-communicating-artery-aneurysms-causing-facial-pain-a-comprehensive-review
#14
REVIEW
Javier Ros de San Pedro
Posterior communicating aneurysms are commonly associated with oculomotor nerve palsy. However, trigeminal nerve involvement among these aneurysms is a rare event with no previous analysis. In order to describe the main features of posterior communicating aneurysms causing trigeminal neuralgia (TGN-PComAAs) eight cases (six from the literature plus two more illustrative cases) were included in the present series. All cases were thoroughly studied in order to collect their epidemiological, radiological, clinical, therapeutic, pathogenic, and outcome data...
September 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28674030/s-nitrosoglutathione-reductase-deficiency-confers-improved-survival-and-neurological-outcome-in-experimental-cerebral-malaria
#15
Robyn E Elphinstone, Rickvinder Besla, Eric A Shikatani, Ziyue Lu, Alfred Hausladen, Matthew Davies, Clinton S Robbins, Mansoor Husain, Jonathan S Stamler, Kevin C Kain
Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important regulator of inflammation and microvascular integrity, and impaired NO bioactivity is associated with fatal outcomes in malaria. Endogenous NO bioactivity in mammals is largely mediated by S-nitrosothiols (SNOs). Based on these observations, we hypothesized that animals deficient in the SNO-metabolizing enzyme, S-nitrosoglutathione reductase (GSNOR), which exhibit enhanced S-nitrosylation, would have improved outcomes in a preclinical model of cerebral malaria...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28645961/cognitive-screening-and-behavioural-observation-of-functional-ability-in-patients-with-multiple-episode-schizophrenia-an-exploratory-study
#16
Eva Norlin Bagge, Eva Esbjörnsson, Katharina S Sunnerhagen
OBJECTIVES: To evaluate the usability of a neuropsychological screening instrument and two observation scales of everyday behaviour to describe cognitive and functional capacity of patients with multiepisode schizophrenia and considerable care needs, who frequently refuse to participate in cognitive testing or performance-based functional measurement. SETTING: One psychiatric unit specialised in severe mental illness at the Sahlgrenska University Hospital, Gothenburg, Sweden...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28627392/the-great-barrier-belief-the-blood-brain-barrier-and-considerations-for-juvenile-toxicity-studies
#17
REVIEW
Georg Schmitt, Neil Parrott, Eric Prinssen, Paul Barrow
Juvenile animal studies can be warranted to support the development of pediatric medicines. Drugs acting on the CNS or those which penetrate into the brain merit particular attention. The blood-brain barrier is functionally mature at birth, but undergoes functional postnatal modulation to provide a suitable microenvironment for the developing brain. In the past, dosing in rat juvenile studies has often commenced at 4 or 7days of age. However, rodents are very neurologically immature at birth compared with humans...
June 13, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28621622/glossopharyngeal-neuralgia-treated-by-gamma-knife-radiosurgery-safety-and-efficacy-through-long-term-follow-up
#18
Benjamin Pommier, Gustavo Touzet, Christian Lucas, Maximilien Vermandel, Serge Blond, Nicolas Reyns
OBJECTIVE Glossopharyngeal neuralgia (GPN) is a rare and disabling condition. Just as for trigeminal neuralgia, Gamma Knife radiosurgery (GKRS) is increasingly proposed as a therapeutic option for GPN. The purpose of this study was to assess long-term safety and efficacy of GKRS for this indication. METHODS From 2007 to 2015, 9 patients (4 male and 5 female) underwent a total of 10 GKRS procedures. All of the patients presented with GPN that was refractory to all medical treatment, and all had a long history of pain...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28607821/frameless-image-guided-radiosurgery-for-trigeminal-neuralgia
#19
Lisa B E Shields, Todd S Shanks, Andrew J Shearer, Lauren A Shelton, Brent J Shelton, Jonathan Howe, James M Coons, Brian Plato, Aaron C Spalding
BACKGROUND: Frameless image-guided radiosurgery (IGRS) is a safe and effective noninvasive treatment for trigeminal neuralgia (TN). This study evaluates the use of frameless IGRS to treat patients with refractory TN. METHODS: We reviewed the records of 20 patients diagnosed with TN who underwent frameless IGRS treatments between March 2012 and December 2013. Facial pain was graded using the Barrow Neurological Institute (BNI) scoring system. The initial setup uncertainty from simulation to treatment and the patient intrafraction uncertainty were measured...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28598279/a-novel-score-to-predict-shunt-dependency-after-aneurysmal-subarachnoid-hemorrhage
#20
Dominik Diesing, Stefan Wolf, Jenny Sommerfeld, Asita Sarrafzadeh, Peter Vajkoczy, Nora F Dengler
OBJECTIVE Feasible clinical scores for predicting shunt-dependent hydrocephalus (SDHC) after aneurysmal subarachnoid hemorrhage (aSAH) are scarce. The chronic hydrocephalus ensuing from SAH score (CHESS) was introduced in 2015 and has a high predictive value for SDHC. Although this score is easy to calculate, several early clinical and radiological factors are required. The authors designed the retrospective analysis described here for external CHESS validation and determination of predictive values for the radiographic Barrow Neurological Institute (BNI) scoring system and a new simplified combined scoring system...
June 9, 2017: Journal of Neurosurgery
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