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https://www.readbyqxmd.com/read/28550715/iridoid-glucosides-in-the-genus-veronica-plantaginaceae-from-new-zealand
#1
Phillip Kroll-Møller, Katja D Pedersen, Chrysoula Gousiadou, Tetsuo Kokubun, Dirk Albach, Rilka Taskova, Phil J Garnock-Jones, Charlotte H Gotfredsen, Søren Rosendal Jensen
Four simple iridoid glucosides, three known esters of catalpol, seven esters of aucubin, and two phenylethanoids were isolated from Veronica hookeri (syn. Hebe ciliolata; Plantaginaceae). Of these, none of four aromatic (p-methoxybenzoyl, isovanilloyl, veratroyl, caffeoyl) 6-O-esters of aucubin and 6″-O-benzoyl mussaenosidic acid, had been reported from nature before. Similarly, three simple iridoid glucosides, two esters of 6-O-rhamnopyranosylcatapol, and two phenylethanoid glucosides, as well as 1-O-benzoyl-3-α-glucuronosylglycerol, and 1-O-β-benzoyl rutinoside were isolated from Veronica pinguifolia (syn...
May 24, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28550707/micrornas-correlate-with-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder-in-a-chinese-population
#2
Jianglong Chen, Jiting Zhu, Zeng Wang, Xiaoping Yao, Xuan Wu, Fang Liu, Weidong Zheng, Zhiwen Li, Aiyu Lin
BACKGROUND Recent studies identified a set of differentially expressed miRNAs in whole blood that may discriminate neuromyelitis optica spectrum disorders (NMOSD) from relapsing-remitting multiple sclerosis (RRMS). This study invalidated 9 known miRNAs in Chinese patients. MATERIAL AND METHODS The levels of miRNAs in whole blood were assayed in healthy controls (n=20) and patients with NMOSD (n=45), RRMS (n=17) by quantitative real-time polymerase chain reaction (qRT-PCR), and pairwise-compared between groups...
May 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28550668/-the-relationship-between-18-f-fdg-pet-ct-metabolic-parameters-and-clinicopathological-features-of-breast-cancer
#3
B Tang, Y Zhang, J Zhou, Y Xu, T R Li, C Y Ding
Objective: To investigate the relationship between metabolic parameters of primary lesion and clinicopathological features of patients with breast cancer. Methods: Clinical data of 78 patients with breast cancer undergone (18)F-FDG PET/CT before surgery was retrospectively analyzed. SUVmax, SUVmean and metabolic tumor volume (MTV) of primary lesions were measured by horizontal, sagittal and coronal position volume section with a threshold of 40% SUVmax. TLG was calculated and the highest SUVmax among metastatic lymph nodes was measured...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28550063/an-environment-friendly-engineered-azotobacter-can-replace-substantial-amount-of-urea-fertilizer-and-yet-sustain-same-wheat-yield
#4
Umesh K Bageshwar, Madhulika Srivastava, Pedisetty Pardha-Saradhi, Sangeeta Paul, Sellamuthu Gothandapani, Ranjeet S Jaat, Prabha Shankar, Rajbir Yadav, Dipak R Biswas, Polumetla A Kumar, Jasdeep C Padaria, Pranab K Mandal, Kannepalli Annapurna, Hirendra K Das
In our endeavor to improve upon nitrogen fixation efficiency of a soil diazotroph that would be unaffected by synthetic nitrogenous fertilizers, we have deleted a part of the negative regulatory gene nifL and constitutively expressed the positive regulatory gene nifA in the chromosome of Azotobacter chroococcum CBD15, a strain isolated from the local field soil. No antibiotic resistance gene or other foreign gene was there in the chromosome of the engineered strain. Wheat seeds inoculated with this engineered strain, which we have named Azotobacter chroococcum HKD15, were tested for three years in pots and one year in the field...
May 26, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28550028/the-impact-of-a-hepatobiliary-multidisciplinary-team-assessment-in-patients-with-colorectal-cancer-liver-metastases-a-population-based-study
#5
Jennie Engstrand, Nikolaos Kartalis, Cecilia Strömberg, Mats Broberg, Anna Stillström, Tobias Lekberg, Eduard Jonas, Jacob Freedman, Henrik Nilsson
BACKGROUND: Assessing patients with colorectal cancer liver metastases (CRCLM) by a liver multidisciplinary team (MDT) results in higher resection rates and improved survival. The aim of this study was to evaluate the potentially improved resection rate in a defined cohort if all patients with CRCLM were evaluated by a liver MDT. PATIENTS AND METHODS: A retrospective analysis of patients diagnosed with colorectal cancer during 2008 in the greater Stockholm region was conducted...
May 26, 2017: Oncologist
https://www.readbyqxmd.com/read/28550009/digital-support-interventions-for-the-self-management-of-low-back-pain-a-systematic-review
#6
Barbara I Nicholl, Louise F Sandal, Mette J Stochkendahl, Marianne McCallum, Nithya Suresh, Ottar Vasseljen, Jan Hartvigsen, Paul J Mork, Per Kjaer, Karen Søgaard, Frances S Mair
BACKGROUND: Low back pain (LBP) is a common cause of disability and is ranked as the most burdensome health condition globally. Self-management, including components on increased knowledge, monitoring of symptoms, and physical activity, are consistently recommended in clinical guidelines as cost-effective strategies for LBP management and there is increasing interest in the potential role of digital health. OBJECTIVE: The study aimed to synthesize and critically appraise published evidence concerning the use of interactive digital interventions to support self-management of LBP...
May 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28549958/a-novel-antegrade-approach-for-simultaneous-carotid-endarterectomy-and-angioplasty-of-proximal-lesions-in-patients-with-tandem-stenosis-of-supraaortic-arch-vessels
#7
Djordje Radak, Slobodan Tanaskovic, Dragan Sagic, Zelimir Antonic, Predrag Gajin, Srdjan Babic, Mihailo Neskovic, Predrag Matic, Vladimir Kovacevic, Dragoslav Nenezic, Nenad Ilijevski
INTRODUCTION: To date all published studies analyzing simultaneous treatment of carotid and proximal atherosclerotic lesions are describing retrograde approach and several technical variations. In the presented study, for the first time antegrade approach is described for simultaneous carotid endarterectomy (CEA) and associated brachiocephalic trunk (BCT) or common carotid artery (CCA) angioplasty in the hybrid operating room. METHODOLOGY: From January 2012 till January 2016 antegrade hybrid procedures were performed in 18 patients...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549931/methodological-systematic-review-identifies-major-limitations-in-prioritisation-processes-for-updating
#8
L Martínez García, H Pardo-Hernandez, C Superchi, E Niño de Guzman, M Ballesteros, N Ibargoyen Roteta, E McFarlane, M Posso, M Roqué I Figuls, R Rotaeche Del Campo, A J Sanabria, A Selva, I Solà, R W M Vernooij, P Alonso-Coello
OBJECTIVE: To identify and describe strategies to prioritise the updating of systematic reviews (SRs), health technology assessments (HTAs), or clinical guidelines (CGs). STUDY DESIGN AND SETTING: We conducted a SR of studies describing one or more methods to prioritise SRs, HTAs, or CGs for updating. We searched MEDLINE (PubMed, from 1966 to August 2016) and The Cochrane Methodology Register (The Cochrane Library, Issue 8 2016). We handsearched abstract books, reviewed reference lists, and contacted experts...
May 23, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28549673/ozone-therapy-protects-against-rejection-in-a-lung-transplantation-model-a-new-treatment
#9
Norberto Santana-Rodríguez, Pedro Llontop, Bernardino Clavo, María D Fiuza-Pérez, Keila Zerecero, Adil Ayub, Khalid Alshehri, Nagib A Yordi, Lamberto Re, Wissam Raad, Leandro Fernández-Pérez, Ricardo García-Herrera, Chyun-Yin J Huang, Faiz Y Bhora
BACKGROUND: No satisfactory treatment exists for chronic rejection (CR) after lung transplantation (LT). Our objective was to assess whether ozone (O3) treatment could ameliorate CR. METHODS: Male Sprague-Dawley inbred rats (n = 36) were randomly assigned into four groups: (1) control (n = 6), (2) sham (n = 6), (3) LT (n = 12), and (4) O3-LT (n = 12). Animals underwent left LT. O3 was rectally administered daily for 2 weeks before LT (from 20 to 50 μg) and 3 times/wk (50 μg/dose) up to 3 months...
May 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28549604/effects-of-eight-different-ligament-property-datasets-on-biomechanics-of-a-lumbar-l4-l5-finite-element-model
#10
S Naserkhaki, N Arjmand, A Shirazi-Adl, F Farahmand, M El-Rich
Ligaments assist trunk muscles in balancing external moments and providing spinal stability. In absence of the personalized material properties for ligaments, finite element (FE) models use dispersed data from the literature. This study aims to investigate the relative effects of eight different ligament property datasets on FE model responses. Eight L4-L5 models distinct only in ligament properties were constructed and loaded under moment (15Nm) alone or combined with a compressive follower load (FL). Range of motions (RoM) of the disc-alone model matched well in vitro data...
May 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28549443/quantitative-analysis-of-cryptic-splicing-associated-with-tdp-43-depletion
#11
Jack Humphrey, Warren Emmett, Pietro Fratta, Adrian M Isaacs, Vincent Plagnol
BACKGROUND: Reliable exon recognition is key to the splicing of pre-mRNAs into mature mRNAs. TDP-43 is an RNA-binding protein whose nuclear loss and cytoplasmic aggregation are a hallmark pathology in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). TDP-43 depletion causes the aberrant inclusion of cryptic exons into a range of transcripts, but their extent, relevance to disease pathogenesis and whether they are caused by other RNA-binding proteins implicated in ALS/FTD are unknown...
May 26, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28549442/characteristics-of-hardcore-smokers-in-south-korea-from-2007-to-2013
#12
EunKyo Kang, Jung A Lee, Hong-Jun Cho
BACKGROUND: As the prevalence of smoking decreased in western countries, a significant proportion of smokers appeared to be particularly resistant to quitting- "hardcore" smokers. This study examines the characteristics of hardcore smokers in South Korea. METHODS: We used the data from 2007 to 2013 from the Korea National Health and Nutrition Examination Survey. Hardcore smoking was defined as (1) smoking >15 cigarettes per day, (2) having no plans of quitting, and (3) having made no attempts to quit...
May 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28549420/prognostic-significance-of-tumor-infiltrating-immune-cells-in-oral-squamous-cell-carcinoma
#13
Juan Fang, Xiaoxu Li, Da Ma, Xiangqi Liu, Yichen Chen, Yun Wang, Vivian Wai Yan Lui, Juan Xia, Bin Cheng, Zhi Wang
BACKGROUND: Prognostic factors aid in the stratification and treatment of cancer. This study evaluated prognostic importance of tumor infiltrating immune cell in patients with oral squamous cell carcinoma. METHODS: Profiles of infiltrating immune cells and clinicopathological data were available for 78 OSCC patients with a median follow-up of 48 months. The infiltrating intensity of CD8, CD4, T-bet, CD68 and CD57 positive cells were assessed by immunohistochemistry...
May 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28549386/newly-developed-dilute-russell-s-viper-venom-reagents-for-lupus-anticoagulant-detection-with-improved-specificity
#14
G W Moore, M Peyrafitte, C Dunois, J Amiral
Background Dilute Russell's viper venom time (dRVVT) is indispensible in lupus anticoagulant (LA) detection yet commercial reagents from different suppliers perform variably, no gold standard assays exist and therapeutic anticoagulation interference is problematic. Objective The objective of this study was to compare a new formulation dRVVT with two currently available dRVVTs. Materials and methods Life Diagnostics (LD) dRVVT and Stago PTT-LA were routinely used for lupus anticoagulant detection, plus Taipan snake venom time/ecarin time (TSVT/ET) for patients on warfarin or rivaroxaban...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28549361/-leukocyte-esterase-as-a-diagnostic-tool-for-an-infectious-disease-of-the-knee
#15
S U Ceja-Picazo, S Fuentes-Figueroa, A H Rivera-Villa, A R Hernández-Salgado, R Torres-González, A M Pérez, J A Hernández-García, J M Pérez-Atanasio
BACKGROUND: Articular infection is an orthopedic challenge due to its difficult diagnosis and devastating results. Various diagnostic studies exist: culture, ESR, CRP, count of leukocytes, among others, but none is specific, they all take more than 30 minutes to complete, and require complex infrastructure. In this study, we determine the sensitivity and specificity of the leukocyte esterase for detection of an infectious process joint in Mexican population. MATERIAL AND METHODS: During November 2015 to April 2016, we obtained synovial fluid from two groups of patients: one with a diagnosis of synovial joint infection with or without implant, and the control group, without infection but with degenerative pathology of the knee...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549094/a-novel-dominant-mutation-in-sag-the-arrestin-1-gene-is-a-common-cause-of-retinitis-pigmentosa-in-hispanic-families-in-the-southwestern-united-states
#16
Lori S Sullivan, Sara J Bowne, Daniel C Koboldt, Elizabeth L Cadena, John R Heckenlively, Kari E Branham, Dianna H Wheaton, Kaylie D Jones, Richard S Ruiz, Mark E Pennesi, Paul Yang, David Davis-Boozer, Hope Northrup, Vsevold V Gurevich, Rui Chen, Mingchu Xu, Yumei Li, David G Birch, Stephen P Daiger
Purpose: To identify the causes of autosomal dominant retinitis pigmentosa (adRP) in a cohort of families without mutations in known adRP genes and consequently to characterize a novel dominant-acting missense mutation in SAG. Methods: Patients underwent ophthalmologic testing and were screened for mutations using targeted-capture and whole-exome next-generation sequencing. Confirmation and additional screening were done by Sanger sequencing. Haplotypes segregating with the mutation were determined using short tandem repeat and single nucleotide variant polymorphisms...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549024/the-epidemiology-of-hospital-death-following-pediatric-severe-sepsis-when-why-and-how-children-with-sepsis-die
#17
Scott L Weiss, Fran Balamuth, Josey Hensley, Julie C Fitzgerald, Jenny Bush, Vinay M Nadkarni, Neal J Thomas, Mark Hall, Jennifer Muszynski
OBJECTIVE: The epidemiology of in-hospital death after pediatric sepsis has not been well characterized. We investigated the timing, cause, mode, and attribution of death in children with severe sepsis, hypothesizing that refractory shock leading to early death is rare in the current era. DESIGN: Retrospective observational study. SETTING: Emergency departments and ICUs at two academic children's hospitals. PATIENTS: Seventy-nine patients less than 18 years old treated for severe sepsis/septic shock in 2012-2013 who died prior to hospital discharge...
May 25, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28549007/surgeon-experience-and-medicare-expenditures-for-laparoscopic-compared-to-open-colectomy
#18
Kyle H Sheetz, Andrew M Ibrahim, Scott E Regenbogen, Justin B Dimick
OBJECTIVE: To quantify the extent to which payments for laparoscopic and open colectomy are influenced by a surgeon's experience with laparoscopy. BACKGROUND: Numerous studies suggest that healthcare costs for laparoscopic colectomy are lower than open surgery. None have assessed the importance of surgeon experience on the relative financial benefits of laparoscopy. METHODS: We conducted a study of 182,852 national Medicare beneficiaries undergoing laparoscopic or open colectomy between 2010 and 2012...
May 25, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28549002/clinical-significance-of-histogram-parameters-on-elastography-in-patients-with-papillary-thyroid-microcarcinomas
#19
Hee Yeun Yoon, Ji Hye Lee, Young Eun Kim, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Y Park, Jin Young Kwak
OBJECTIVE: The purpose of our study was to determine objective histogram parameters on elastography that could predict poor prognosis factors of conventional papillary thyroid microcarcinomas (PTMCs). METHODS: From September to November in 2012, 79 patients with a diagnosis of PTMCs were included. Mean values of clinicopathologic variables and histogram parameters on elastography were compared between groups with or without poor prognostic factors using the Student t test, χ test, or Fisher exact test...
May 25, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28548951/development-of-a-novel-score-for-the-prediction-of-hospital-mortality-in-patients-with-severe-sepsis-the-use-of-electronic-healthcare-records-with-lasso-regression
#20
Zhongheng Zhang, Yucai Hong
BACKGROUND AND OBJECTIVE: There are several disease severity scores being used for the prediction of mortality in critically ill patients. However, none of them was developed and validated specifically for patients with severe sepsis. The present study aimed to develop a novel prediction score for severe sepsis. RESULTS: A total of 3206 patients with severe sepsis were enrolled, including 1054 non-survivors and 2152 survivors. The LASSO score showed the best discrimination (area under curve: 0...
May 15, 2017: Oncotarget
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