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Arterial stiffness AND depression

Kohji Shirai
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new arterial stiffness index of the arterial tree from the origin of the aorta to the ankle, and was essentially derived from the stiffness parameterβtheory proposed by Hayashi. The conspicuous feature of CAVI is independency from blood pressure at the time of measurement. AIM: The purpose is to clarify the meaning of CAVI as a surrogate marker of arteriosclerosis, and also the role of CAVI in the blood pressure control system...
September 2016: Journal of Hypertension
Kohji Shirai
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new arterial stiffness index of the arterial tree from the origin of the aorta to the ankle, and was essentially derived from the stiffness parameterβtheory proposed by Hayashi. The conspicuous feature of CAVI is independency from blood pressure at the time of measurement. AIM: The purpose is to clarify the meaning of CAVI as a surrogate marker of arteriosclerosis, and also the role of CAVI in the blood pressure control system...
September 2016: Journal of Hypertension
Stefan L C Geijselaers, Simone J S Sep, Miranda T Schram, Martin P J van Boxtel, Thomas T van Sloten, Ronald M A Henry, Koen D Reesink, Abraham A Kroon, Annemarie Koster, Nicolaas C Schaper, Pieter C Dagnelie, Carla J H van der Kallen, Geert Jan Biessels, Coen D A Stehouwer
BACKGROUND AND AIMS: There is increasing evidence linking arterial (mainly aortic) stiffness and type 2 diabetes, a risk factor for arterial stiffness, to cognitive impairment and dementia. However, data on carotid stiffness, which may be especially relevant for cognitive performance, are scarce, and few studies have addressed the interplay between arterial stiffness, type 2 diabetes, and cognitive performance. METHODS: We studied individuals with (n = 197) and without (n = 528) type 2 diabetes, who completed a neuropsychological test battery and underwent applanation tonometry and vascular ultrasound to evaluate aortic (i...
October 2016: Atherosclerosis
Andrea László, Ádám Tabák, Beáta Kőrösi, Dániel Eörsi, Péter Torzsa, Orsolya Cseprekál, András Tislér, György Reusz, Zsófia Nemcsik-Bencze, Xénia Gonda, Zoltán Rihmer, János Nemcsik
BACKGROUND: Affective temperaments (anxious, depressive, cyclothymic, irritable and hyperthymic) measure subclinical manifestations of major mood disorders. Furthermore, cumulating evidence suggests their involvement in somatic disorders as well. We aimed to assess associations between affective temperament scores and blood pressure and arterial stiffness parameters in hypertensive patients. METHODS: In this cross-sectional study, 173 patients with well-controlled or grade 1 chronic hypertension, with no history of depression, completed the TEMPS-A, Beck Depression Inventory (BDI) and Hamilton Anxiety Scale (HAM-A) questionnaires in three GP practices...
2016: BMC Cardiovascular Disorders
János Nemcsik, Andrea László, Lilla Lénárt, Dániel Eörsi, Péter Torzsa, Beáta Kőrösi, Orsolya Cseprekál, András Tislér, Ádám Tabák, Xenia Gonda, Zoltán Rihmer, Judit Hodrea, Zsófia Nemcsik-Bencze, Andrea Fekete
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has neuroprotective, proangiogenic and myogenic effects and, therefore, possibly acts as a psychosomatic mediator. Here, we measured serum BDNF (seBDNF) level in hypertensive patients (HT) and healthy controls (CONT) and its relation to affective temperaments, depression and anxiety scales, and arterial stiffness parameters. METHODS: In this cross-sectional study, affective temperaments, anxiety, and depression were studied with questionnaires (TEMPS-A, HAM-A, and BDI, respectively)...
2016: Annals of General Psychiatry
Omer Yanartas, Murat Sunbul, Zeynep Senkal, Erdal Durmus, Tarik Kivrak, Nilufer Subasi, Gulhan Karaer, Serhat Ergun, Ibrahim Sari, Kemal Sayar
BACKGROUND: The relationship between mental stress and cardiovascular disease has been shown in several studies. Panic disorder (PD) is also associated with cardiovascular disease due to increased risk of myocardial infarction. The aim of this study is to evaluate the association between arterial stiffness parameters and depression/anxiety scores in patients with PD. METHODS: The study population consisted of 25 patients with PD and 25 age-sex-matched healthy controls...
2016: Annals of General Psychiatry
Ying Xiao, Xin Nie, Pengfei Han, Haiying Fu, Y James Kang
Myocardial ischemia leads to a decrease in copper (Cu) concentrations, along with collagen deposition in which Cu-dependent lysyl oxidase (LOX) catalyzes the cross-linking of collagens leading to tissue stiffness. The present study was undertaken to determine the relationship between decreased Cu concentrations and LOX activities in ischemic hearts of monkeys. Rhesus monkeys were subjected to coronary artery ligation, leading to ischemic infarction. At 8 weeks after the surgery, Cu concentrations and Cu-dependent cytochrome c oxidase (CCO) activities in the infarct area were significantly decreased...
September 1, 2016: Metallomics: Integrated Biometal Science
Andrea László, Levente Babos, Zsóka Kis-Igari, Adrienn Pálfy, Péter Torzsa, Ajándék Eőry, László Kalabay, Xenia Gonda, Zoltán Rihmer, Orsolya Cseprekál, András Tislér, Judit Hodrea, Lilla Lénárt, Andrea Fekete, János Nemcsik
BACKGROUND: Although mood disorders and cardiovascular diseases have widely studied psychosomatic connections, data concerning the influence of the psychopathologically important affective temperaments in hypertension are scarce. To define a possibly higher cardiovascular risk subpopulation we investigated in well-treated hypertensive patients with dominant affective temperaments (DOM) and in well-treated hypertensive patients without dominant temperaments the level of depression and anxiety, arterial stiffness and serum Brain-derived Neurotrophic Factor (seBDNF)...
2015: Annals of General Psychiatry
Thomas T van Sloten, Gary F Mitchell, Sigurdur Sigurdsson, Mark A van Buchem, Palmi V Jonsson, Melissa E Garcia, Tamara B Harris, Ronald M A Henry, Andrew S Levey, Coen D A Stehouwer, Vilmundur Gudnason, Lenore J Launer
BACKGROUND: Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association. METHODS: This cross-sectional study included a subset of participants from the AGES-Reykjavik study second examination round, which was conducted from 2007 to 2011. Arterial stiffness (carotid-femoral pulse wave velocity [CFPWV]), depressive symptoms (15-item geriatric depression scale [GDS-15]) and cerebral small vessel disease (MRI) were determined...
April 2016: Journal of Psychiatry & Neuroscience: JPN
Sylvestre Maréchaux, Rohan Samson, Eric van Belle, Joke Breyne, Juliette de Monte, Céline Dédrie, Nassim Chebai, Aymeric Menet, Carlo Banfi, Nadia Bouabdallaoui, Thierry H Le Jemtel, Pierre-Vladimir Ennezat
BACKGROUND: Assessment of vascular endothelial function lacks consistency, and microvascular endothelial function has been only partly assessed in heart failure with preserved ejection fraction (HFpEF). METHODS: The study population consisted of 90 patients: 45 had well documented HFpEF, and 45 had hypertension and no history or evidence of heart failure. Patients with hypertension but no heart failure were matched with HFpEF patients for age, sex, and diabetes...
January 2016: Journal of Cardiac Failure
A E Schutte, L J Ware, K L Rennie, L F Gafane, T M Nell, J E S Thompson, R Schutte
OBJECTIVE: While South Africa has one of the highest rates of hypertension globally, data on masked and white coat hypertension in the region is scant. This study sought to determine the frequency of masked and white coat hypertension in low income South African adults and to evaluate cardiovascular risk through measures of arterial stiffness. DESIGN AND METHOD: We included 81 low income adults (50% men, 96% black, 4% coloured) aged 19-63 years, and measured clinic blood pressure four times (twice on each upper arm) with the Omron M10-IT automated device; also 24 hour ambulatory blood pressure with pulse wave analysis (Mobil-O-Graph ABPM), anthropometry and HIV status...
June 2015: Journal of Hypertension
Yusuke Osonoi, Tomoya Mita, Takeshi Osonoi, Miyoko Saito, Atsuko Tamasawa, Shiho Nakayama, Yuki Someya, Hidenori Ishida, Akio Kanazawa, Masahiko Gosho, Yoshio Fujitani, Hirotaka Watada
BACKGROUND: While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship. METHODS: The study participants comprised 724 Japanese T2DM outpatients free of history of cardiovascular diseases. The relationships between sleep quality (assessed by the Pittsburgh Sleep Quality Index (PSQI)) and various clinical and laboratory parameters were investigated...
2015: BMC Endocrine Disorders
Monica Jane, Jonathan Foster, Martin Hagger, Sebely Pal
BACKGROUND: Over the last three decades, overweight and obesity and the associated health consequences have become global public health priorities. Methods that have been tried to address this problem have not had the desired impact, suggesting that other approaches need to be considered. One of the lessons learned throughout these attempts is that permanent weight loss requires sustained dietary and lifestyle changes, yet adherence to weight management programs has often been noted as one of the biggest challenges...
2015: BMC Public Health
Christian H Dall, Finn Gustafsson, Stefan B Christensen, Flemming Dela, Henning Langberg, Eva Prescott
BACKGROUND: Growing evidence in long-term treatment of heart transplant (HTx) recipients indicates effects of high-intensity interval training (HIIT) on several parameters, including oxygen uptake, vascular function and psychological distress. In this study we compare the effect of HIIT vs continued moderate training (CON) on vascular function, biomarkers and health-related quality of life (HRQoL) in HTx recipients. METHODS: A randomized, controlled crossover trial of stable HTx recipients >12 months after transplantation was done on patients with 12 weeks of HIIT or 12 weeks of CON, followed by a 5-month washout and crossover...
August 2015: Journal of Heart and Lung Transplantation
Ross W May, Marcos A Sanchez-Gonzalez, Frank D Fincham
Two studies examined autonomic and cardiovascular functioning that may link school burnout to cardiovascular risk factors in young healthy adult females. Study 1 (N = 136) investigated whether school burnout was related to resting values of blood pressure (BP) and blood pressure variability (BPV) through laboratory beat-to-beat BP assessment. Study 2 (N = 94) examined the link between school burnout and diurnal BPV through ambulatory BP monitoring. Controlling for anxiety and depressive symptomatology, school burnout demonstrated strong positive relationships with indices of cardiac sympathovagal tone, sympathetic vasomotor tone, inefficient myocardial oxygen consumption, increased 24-h ambulatory heart rate and BP, blunted BP diurnal variability, and increased arterial stiffness...
January 2015: Stress: the International Journal on the Biology of Stress
Albert Stuart Reece, Gary Kenneth Hulse
OBJECTIVE: To characterise and compare the potentiation of arterial stiffness and vascular ageing by opioids in men and women. DESIGN: Cross-sectional and longitudinal studies of 576 clinical controls and 687 opioid-dependent patients (ODP) on 710 and 1305 occasions, respectively, over a total of 2382 days (6.52 years), 2006-2011. Methodology Radial pulse wave analysis with Atcor SphygmoCor system (Sydney). SETTING: Primary care. PARTICIPANTS: HASH(0x4a3cde8) CONTROLS: General practice patients with non-cardiovascular disorders, and university student controls...
2014: BMJ Open
Wenfei Zhu, Steven P Hooker, Yuliang Sun, Minhao Xie, Hao Su, Jianmin Cao
BACKGROUND: High levels of physical activity (PA) and cardiorespiratory fitness (CRF) are each associated with a favorable cardiovascular disease (CVD) risk profile. However, the relationship between CRF and obesity is still inconsistent across studies, and there has been no thorough exploration of the independent contribution of CRF to different CVD risk factors in Chinese women. This study investigated the relationship between CRF and CVD risk factors in 40-49 year old women in Beijing...
2014: BMC Women's Health
Tu H Mai, Jing Wu, André Diedrich, Emily M Garland, David Robertson
Calcitonin gene-related peptide (CGRP) is reported to play important roles in cardiovascular regulation in human and animal models. In spite of this, its role remains controversial. We aim to clarify this by studying the autonomic cardiovascular function and vascular structure in CGRP knockout (CGRP(-/-)) mice. Blood pressure (BP) and heart rate (HR) were assessed by telemeters. Urine (24-hour) and blood were collected for catecholamines measurements. Baroreflex sensitivity was assessed using phenylephrine and sodium nitroprusside administered in an acute study...
May 2014: Journal of the American Society of Hypertension: JASH
Lara M Durrant, Omid Khorram, John N Buchholz, William J Pearce
Although the effects of prenatal undernutrition on adult cardiovascular health have been well studied, its effects on the cerebrovascular structure and function remain unknown. We used a pair-fed rat model of 50% caloric restriction from day 11 of gestation to term, with ad libitum feeding after birth. We validated that maternal food restriction (MFR) stress is mediated by glucocorticoids by administering metyrapone, a corticosterone synthesis inhibitor, to MFR mothers at day 11 of gestation. At age 8 mo, offspring from Control, MFR, and MFR + Metyrapone groups were killed, and middle cerebral artery (MCA) segments were studied using vessel-bath myography and confocal microscopy...
March 15, 2014: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Angelo Scuteri, Manfredi Tesauro, Letizia Guglini, Davide Lauro, Massimo Fini, Nicola Di Daniele
OBJECTIVE: Though CV risk factors and markers of arterial aging are recognized risky for cognition, no study has simultaneously investigated the impact of multiple cardiac, arterial (large and small vessels), and hemodynamic parameters on cognitive function in older subjects. METHODS: Two hundred eighty older subjects with subjective complaints of memory loss and no previous stroke (mean age 78.3 ± 6.3 years) were studied. Global cognitive function was evaluated with the Mini-Mental State Examination (MMSE)...
November 20, 2013: International Journal of Cardiology
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