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Arterial stiffness AND depression

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https://www.readbyqxmd.com/read/28914847/-efficiency-of-triple-antihypertensive-therapy-in-patients-with-uncontrolled-hypertension-and-depressive-disorders
#1
V V Skibitsky, A V Fendrikova, A V Skibitsky
AIM: To evaluate the efficiency of triple antihypertensive therapy in patients with uncontrolled hypertension and depressive disorders (DD). MATERIAL AND METHODS: 153 patients with uncontrolled hypertension were examined, of whom 82 patients were diagnosed with mild and moderate DD. A combination of perindopril 10 mg/day, indapamide SR 1.5 mg/day, and amlodipine at an initial dose of 5 mg/day was given to patients with hypertension and DD. After 4 weeks of treatment, if target blood pressure (BP) levels could not be achieved, the dose of amlodipine was increased up to 10 mg/day...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28864708/does-supplementation-with-carnosine-improve-cardiometabolic-health-and-cognitive-function-in-patients-with-pre-diabetes-and-type-2-diabetes-study-protocol-for-a-randomised-double-blind-placebo-controlled-trial
#2
Estifanos Baye, Kirthi Menon, Maximilian Pj de Courten, Arul Earnest, James Cameron, Barbora de Courten
INTRODUCTION: Carnosine, an over-the-counter food supplement, has a promising potential for the prevention and treatment of chronic diseases such as type 2 diabetes (T2DM), cardiovascular and neurodegenerative diseases through its anti-inflammatory, antiglycation, antioxidative and chelating effects. We have previously shown that supplementation with carnosine preserves insulin sensitivity and secretion in non-diabetic overweight and obese individuals. The effect of carnosine on cardiometabolic risk and related cognitive outcomes in patients with pre-diabetes and T2DM has thus far not been studied...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28769817/suicidal-ideation-is-associated-with-altered-variability-of-fingertip-photo-plethysmogram-signal-in-depressed-patients
#3
Ahsan H Khandoker, Veena Luthra, Yousef Abouallaban, Simanto Saha, Khawza I U Ahmed, Raqibul Mostafa, Nayeefa Chowdhury, Herbert F Jelinek
Physiological and psychological underpinnings of suicidal behavior remain ill-defined and lessen timely diagnostic identification of this subgroup of patients. Arterial stiffness is associated with autonomic dysregulation and may be linked to major depressive disorder (MDD). The aim of this study was to investigate the association between arterial stiffness by photo-plethysmogram (PPG) in MDD with and without suicidal ideation (SI) by applying multiscale tone entropy (T-E) variability analysis. Sixty-one 10-min PPG recordings were analyzed from 29 control, 16 MDD patients with (MDDSI+) and 16 patients without SI (MDDSI-)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28683960/arterial-stiffening-with-exercise-in-patients%C3%A2-with-heart-failure-and-preserved%C3%A2-ejection-fraction
#4
RANDOMIZED CONTROLLED TRIAL
Yogesh N V Reddy, Mads J Andersen, Masaru Obokata, Katlyn E Koepp, Garvan C Kane, Vojtech Melenovsky, Thomas P Olson, Barry A Borlaug
BACKGROUND: Aortic stiffening and reduced nitric oxide (NO) availability may contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). OBJECTIVES: This study compared indices of arterial stiffness at rest and during exercise in subjects with HFpEF and hypertensive control subjects to examine their relationships to cardiac hemodynamics and determine whether exertional arterial stiffening can be mitigated by inorganic nitrite. METHODS: A total of 22 hypertensive control subjects and 98 HFpEF subjects underwent hemodynamic exercise testing with simultaneous expired gas analysis to measure oxygen consumption...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28559662/the-relationship-between-brachial-ankle-pulse-wave-velocity-and-depressive-symptoms-among-patients-with-coronary-artery-disease
#5
I-Mei Lin, Hsueh-Chen Lu, Chih-Sheng Chu, Chee-Siong Lee, Ye-Hsu Lu, Tsung-Hsien Lin
BACKGROUND: Noninvasive brachial-ankle pulse wave velocity (baPWV) is an index for arterial stiffness in coronary artery disease (CAD). Depression has been connected to increased adverse cardiac events and mortality among patients with CAD. The aim of this study was to investigate the relationship between arterial stiffness and depressive symptoms among patients with CAD. METHODS: Eighty-six patients with CAD were recruited. Demographic characteristics and Beck Depressive Inventory II scores were obtained from the study participants, and resting baPWV was measured by using a noninvasive device...
May 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28467955/the-impact-of-currently-recommended-antihypertensive-therapy-on-depression-and-other-psychometric-parameters-preliminary-communication
#6
Beata Korosi, Andrea Laszlo, Adam Tabak, Dora Batta, Lilla Lenart, Andrea Fekete, Daniel Eorsi, Orsolya Cseprekal, Andras Tisler, Zsofia Nemcsik-Bencze, Xenia Gonda, Zoltan Rihmer, Janos Nemcsik
AIMS: Current evidence on the psychological effects of antihypertensive medications is controversial. The aim of this study was to evaluate the effect of current antihypertensive medication on different psychometric parameters and on serum brain-derived neurotrophic factor (BDNF) level. METHODS: Psychometric, haemodynamic, arterial stiffness and laboratory parameters were evaluated before and 3 months after the initiation of antihypertensive medication in untreated hypertensive patients (HT, n=31), and once in healthy controls (CONT, n=22)...
March 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/27753856/hw-01-4-cardioankle-vascular-index-cavi-in-hypertension
#7
Kohji Shirai
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new arterial stiffness index of the arterial tree from the origin of the aorta to the ankle, and was essentially derived from the stiffness parameterβtheory proposed by Hayashi. The conspicuous feature of CAVI is independency from blood pressure at the time of measurement. AIM: The purpose is to clarify the meaning of CAVI as a surrogate marker of arteriosclerosis, and also the role of CAVI in the blood pressure control system...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643093/hw-01-4-cardioankle-vascular-index-cavi-in-hypertension
#8
Kohji Shirai
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new arterial stiffness index of the arterial tree from the origin of the aorta to the ankle, and was essentially derived from the stiffness parameterβtheory proposed by Hayashi. The conspicuous feature of CAVI is independency from blood pressure at the time of measurement. AIM: The purpose is to clarify the meaning of CAVI as a surrogate marker of arteriosclerosis, and also the role of CAVI in the blood pressure control system...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27503567/carotid-stiffness-is-associated-with-impairment-of-cognitive-performance-in-individuals-with-and-without-type-2-diabetes-the-maastricht-study
#9
Stefan L C Geijselaers, Simone J S Sep, Miranda T Schram, Martin P J van Boxtel, Thomas T van Sloten, Ronald M A Henry, Koen D Reesink, Abraham A Kroon, Annemarie Koster, Nicolaas C Schaper, Pieter C Dagnelie, Carla J H van der Kallen, Geert Jan Biessels, Coen D A Stehouwer
BACKGROUND AND AIMS: There is increasing evidence linking arterial (mainly aortic) stiffness and type 2 diabetes, a risk factor for arterial stiffness, to cognitive impairment and dementia. However, data on carotid stiffness, which may be especially relevant for cognitive performance, are scarce, and few studies have addressed the interplay between arterial stiffness, type 2 diabetes, and cognitive performance. METHODS: We studied individuals with (n = 197) and without (n = 528) type 2 diabetes, who completed a neuropsychological test battery and underwent applanation tonometry and vascular ultrasound to evaluate aortic (i...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27503108/association-of-affective-temperaments-with-blood-pressure-and-arterial-stiffness-in-hypertensive-patients-a-cross-sectional-study
#10
Andrea László, Ádám Tabák, Beáta Kőrösi, Dániel Eörsi, Péter Torzsa, Orsolya Cseprekál, András Tislér, György Reusz, Zsófia Nemcsik-Bencze, Xénia Gonda, Zoltán Rihmer, János Nemcsik
BACKGROUND: Affective temperaments (anxious, depressive, cyclothymic, irritable and hyperthymic) measure subclinical manifestations of major mood disorders. Furthermore, cumulating evidence suggests their involvement in somatic disorders as well. We aimed to assess associations between affective temperament scores and blood pressure and arterial stiffness parameters in hypertensive patients. METHODS: In this cross-sectional study, 173 patients with well-controlled or grade 1 chronic hypertension, with no history of depression, completed the TEMPS-A, Beck Depression Inventory (BDI) and Hamilton Anxiety Scale (HAM-A) questionnaires in three GP practices...
August 8, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27478486/hyperthymic-affective-temperament-and-hypertension-are-independent-determinants-of-serum-brain-derived-neurotrophic-factor-level
#11
János Nemcsik, Andrea László, Lilla Lénárt, Dániel Eörsi, Péter Torzsa, Beáta Kőrösi, Orsolya Cseprekál, András Tislér, Ádám Tabák, Xenia Gonda, Zoltán Rihmer, Judit Hodrea, Zsófia Nemcsik-Bencze, Andrea Fekete
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has neuroprotective, proangiogenic and myogenic effects and, therefore, possibly acts as a psychosomatic mediator. Here, we measured serum BDNF (seBDNF) level in hypertensive patients (HT) and healthy controls (CONT) and its relation to affective temperaments, depression and anxiety scales, and arterial stiffness parameters. METHODS: In this cross-sectional study, affective temperaments, anxiety, and depression were studied with questionnaires (TEMPS-A, HAM-A, and BDI, respectively)...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27279893/increased-arterial-stiffness-parameters-in-panic-disorder-patients-in-long-term-treatment-period
#12
Omer Yanartas, Murat Sunbul, Zeynep Senkal, Erdal Durmus, Tarik Kivrak, Nilufer Subasi, Gulhan Karaer, Serhat Ergun, Ibrahim Sari, Kemal Sayar
BACKGROUND: The relationship between mental stress and cardiovascular disease has been shown in several studies. Panic disorder (PD) is also associated with cardiovascular disease due to increased risk of myocardial infarction. The aim of this study is to evaluate the association between arterial stiffness parameters and depression/anxiety scores in patients with PD. METHODS: The study population consisted of 25 patients with PD and 25 age-sex-matched healthy controls...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27210292/decreased-copper-concentrations-but-increased-lysyl-oxidase-activity-in-ischemic-hearts-of-rhesus-monkeys
#13
Ying Xiao, Xin Nie, Pengfei Han, Haiying Fu, Y James Kang
Myocardial ischemia leads to a decrease in copper (Cu) concentrations, along with collagen deposition in which Cu-dependent lysyl oxidase (LOX) catalyzes the cross-linking of collagens leading to tissue stiffness. The present study was undertaken to determine the relationship between decreased Cu concentrations and LOX activities in ischemic hearts of monkeys. Rhesus monkeys were subjected to coronary artery ligation, leading to ischemic infarction. At 8 weeks after the surgery, Cu concentrations and Cu-dependent cytochrome c oxidase (CCO) activities in the infarct area were significantly decreased...
September 1, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/26512294/identification-of-hypertensive-patients-with-dominant-affective-temperaments-might-improve-the-psychopathological-and-cardiovascular-risk-stratification-a-pilot-case-control-study
#14
Andrea László, Levente Babos, Zsóka Kis-Igari, Adrienn Pálfy, Péter Torzsa, Ajándék Eőry, László Kalabay, Xenia Gonda, Zoltán Rihmer, Orsolya Cseprekál, András Tislér, Judit Hodrea, Lilla Lénárt, Andrea Fekete, János Nemcsik
BACKGROUND: Although mood disorders and cardiovascular diseases have widely studied psychosomatic connections, data concerning the influence of the psychopathologically important affective temperaments in hypertension are scarce. To define a possibly higher cardiovascular risk subpopulation we investigated in well-treated hypertensive patients with dominant affective temperaments (DOM) and in well-treated hypertensive patients without dominant temperaments the level of depression and anxiety, arterial stiffness and serum Brain-derived Neurotrophic Factor (seBDNF)...
2015: Annals of General Psychiatry
https://www.readbyqxmd.com/read/26505140/associations-between-arterial-stiffness-depressive-symptoms-and-cerebral-small-vessel-disease-cross-sectional-findings-from-the-ages-reykjavik-study
#15
Thomas T van Sloten, Gary F Mitchell, Sigurdur Sigurdsson, Mark A van Buchem, Palmi V Jonsson, Melissa E Garcia, Tamara B Harris, Ronald M A Henry, Andrew S Levey, Coen D A Stehouwer, Vilmundur Gudnason, Lenore J Launer
BACKGROUND: Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association. METHODS: This cross-sectional study included a subset of participants from the AGES-Reykjavik study second examination round, which was conducted from 2007 to 2011. Arterial stiffness (carotid-femoral pulse wave velocity [CFPWV]), depressive symptoms (15-item geriatric depression scale [GDS-15]) and cerebral small vessel disease (MRI) were determined...
April 2016: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/26386451/vascular-and-microvascular-endothelial-function-in-heart-failure-with-preserved-ejection-fraction
#16
Sylvestre Maréchaux, Rohan Samson, Eric van Belle, Joke Breyne, Juliette de Monte, Céline Dédrie, Nassim Chebai, Aymeric Menet, Carlo Banfi, Nadia Bouabdallaoui, Thierry H Le Jemtel, Pierre-Vladimir Ennezat
BACKGROUND: Assessment of vascular endothelial function lacks consistency, and microvascular endothelial function has been only partly assessed in heart failure with preserved ejection fraction (HFpEF). METHODS: The study population consisted of 90 patients: 45 had well documented HFpEF, and 45 had hypertension and no history or evidence of heart failure. Patients with hypertension but no heart failure were matched with HFpEF patients for age, sex, and diabetes...
January 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/26102922/6a-08-high-frequency-of-masked-hypertension-and-associated-arterial-stiffness-in-africans
#17
A E Schutte, L J Ware, K L Rennie, L F Gafane, T M Nell, J E S Thompson, R Schutte
OBJECTIVE: While South Africa has one of the highest rates of hypertension globally, data on masked and white coat hypertension in the region is scant. This study sought to determine the frequency of masked and white coat hypertension in low income South African adults and to evaluate cardiovascular risk through measures of arterial stiffness. DESIGN AND METHOD: We included 81 low income adults (50% men, 96% black, 4% coloured) aged 19-63 years, and measured clinic blood pressure four times (twice on each upper arm) with the Omron M10-IT automated device; also 24 hour ambulatory blood pressure with pulse wave analysis (Mobil-O-Graph ABPM), anthropometry and HIV status...
June 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/26084960/poor-sleep-quality-is-associated-with-increased-arterial-stiffness-in-japanese-patients-with-type-2-diabetes-mellitus
#18
Yusuke Osonoi, Tomoya Mita, Takeshi Osonoi, Miyoko Saito, Atsuko Tamasawa, Shiho Nakayama, Yuki Someya, Hidenori Ishida, Akio Kanazawa, Masahiko Gosho, Yoshio Fujitani, Hirotaka Watada
BACKGROUND: While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship. METHODS: The study participants comprised 724 Japanese T2DM outpatients free of history of cardiovascular diseases. The relationships between sleep quality (assessed by the Pittsburgh Sleep Quality Index (PSQI)) and various clinical and laboratory parameters were investigated...
2015: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/26012783/using-new-technologies-to-promote-weight-management-a-randomised-controlled-trial-study-protocol
#19
RANDOMIZED CONTROLLED TRIAL
Monica Jane, Jonathan Foster, Martin Hagger, Sebely Pal
BACKGROUND: Over the last three decades, overweight and obesity and the associated health consequences have become global public health priorities. Methods that have been tried to address this problem have not had the desired impact, suggesting that other approaches need to be considered. One of the lessons learned throughout these attempts is that permanent weight loss requires sustained dietary and lifestyle changes, yet adherence to weight management programs has often been noted as one of the biggest challenges...
2015: BMC Public Health
https://www.readbyqxmd.com/read/25840503/effect-of-moderate-versus-high-intensity-exercise-on-vascular-function-biomarkers-and-quality-of-life-in-heart-transplant-recipients-a-randomized-crossover-trial
#20
RANDOMIZED CONTROLLED TRIAL
Christian H Dall, Finn Gustafsson, Stefan B Christensen, Flemming Dela, Henning Langberg, Eva Prescott
BACKGROUND: Growing evidence in long-term treatment of heart transplant (HTx) recipients indicates effects of high-intensity interval training (HIIT) on several parameters, including oxygen uptake, vascular function and psychological distress. In this study we compare the effect of HIIT vs continued moderate training (CON) on vascular function, biomarkers and health-related quality of life (HRQoL) in HTx recipients. METHODS: A randomized, controlled crossover trial of stable HTx recipients >12 months after transplantation was done on patients with 12 weeks of HIIT or 12 weeks of CON, followed by a 5-month washout and crossover...
August 2015: Journal of Heart and Lung Transplantation
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