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https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#1
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29653154/association-between-intra-and-post-arrest-hyperoxia-on-mortality-in-adults-with-cardiac-arrest-a-systematic-review-and-meta-analysis
#2
REVIEW
Jignesh K Patel, Abdo Kataya, Puja B Parikh
OBJECTIVES: The association between intra-arrest and post-arrest hyperoxia and mortality in adults with cardiac arrest (CA) is widely debated. We therefore conducted a systematic review and meta-analysis to investigate the association between intra-arrest and post-arrest hyperoxia and mortality in adults with CA. METHODS: We systematically searched MEDLINE and Cochrane databases to identify observational studies from January 2008 to December 2017 investigating the relationship between hyperoxia (either intra-arrest or post-arrest) and mortality in adults with CA...
April 10, 2018: Resuscitation
https://www.readbyqxmd.com/read/29652573/quantitative-assessment-of-shotgun-metagenomics-and-16s-rdna-amplicon-sequencing-in-the-study-of-human-gut-microbiome
#3
Ilaria Laudadio, Valerio Fulci, Francesca Palone, Laura Stronati, Salvatore Cucchiara, Claudia Carissimi
The analysis of microbiota composition in humans, animals, and built environments is important because of emerging roles and applications in a broad range of disease and ecological phenotypes. Next Generation Sequencing is the current method of choice to characterize microbial community composition. The taxonomic profile of a microbial community can be obtained either by shotgun analysis of random DNA fragments or through 16S ribosomal RNA gene (rDNA) amplicon sequencing. It has been previously shown that the 16S rDNA amplicon sequencing approach yields quantitatively and qualitatively different results compared to shotgun metagenomics when the two techniques are used to assess microbial community composition on the same samples...
April 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29650025/effectiveness-of-health-education-as-an-intervention-designed-to-prevent-female-genital-mutilation-cutting-fgm-c-a-systematic-review
#4
REVIEW
Susan Waigwa, Lucy Doos, Caroline Bradbury-Jones, Julie Taylor
BACKGROUND: Female Genital Mutilation/Cutting (FGM/C) is a harmful practice that violates the human rights of women and girls. Despite global efforts to restrict the practice, there have been few reports on major positive changes to the problem. Health education interventions have been successful in preventing various health conditions and promoting service use. They have also been regarded as promising interventions for preventing FGM/C. The objective of this systematic review is to synthesise findings of studies about effectiveness of health education as an intervention to prevent FGM/C...
April 12, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29649053/bilateral-congenital-cholesteatoma
#5
Chang Ho Lee, Mi Kyung Kim, Hyoung-Mi Kim, Cheongse Won, Tae Hyun Shin, So Young Kim
OBJECTIVE: To report the first large case series of extremely rare bilateral congenital cholesteatoma (CC). STUDY DESIGN: A retrospective cohort study. SETTING: University hospital otology referral clinic. PATIENTS: Six hundred four children with surgically confirmed CC. MAIN OUTCOME MEASURES: The bilateral CCs were compared with the unilateral CCs. RESULTS: The incidence of bilateral CC was 3...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29645300/a-comparison-of-extraction-systems-for-plant-water-stable-isotope-analysis
#6
Cody Millar, Dyan Pratt, Dave Schneider, Jeffrey J McDonnell
RATIONALE: The stable isotope ratios of water (δ2 H and δ18 O values) have been widely used to trace water in plants in a variety of physiological, ecohydrological, biogeochemical and hydrological studies. In such work, the analyte must first be extracted from samples, prior to isotopic analysis. While cryogenic vacuum distillation is currently the most widely used method in the literature, a variety of extraction-collection-analysis methods exist. A formal inter-method comparison on plant tissues has yet to be carried out...
April 12, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29644813/endovascular-repair-of-aortic-arch-disease-with-double-inner-branched-thoracic-stent-graft-the-bolton-perspective
#7
Ciro Ferrer, Carlo Coscarella, Piergiorgio Cao
BACKGROUND: In the light of current evidence, endovascular repair of aortic arch pathologies with custom-made devices should be considered a valid alternative to decrease operative mortality and morbidity associated with open or hybrid repair. Today, two double inner branch devices are available on market. We report our single-center experience with Bolton double branch stent graft in the treatment of aortic arch disease. METHODS: Between 2013 and 2016, 15 high-risk patients with arch pathology were treated in our center with a custom-made branched device...
April 11, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29644398/stent-placement-in-patients-with-acute-subarachnoid-haemorrhage-when-is-it-justified
#8
Andrew G Murchison, Victoria Young, Tanja Ddjurdjevic, Martino Cellerini, Rufus Corkill, Wilhelm Küker
PURPOSE: Endovascular stents are widely used for the elective treatment of cerebral aneurysms. Acute stenting is performed in the management of dissections, pseudo-aneurysms, broad-based aneurysms or as a 'bail out' measure after coil migration. The purpose of this study is to review the safety of using stents in acute subarachnoid haemorrhage. METHODS: The stent registry of our institution was reviewed for procedures in patients with acute subarachnoid haemorrhage...
April 11, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29643879/transesophageal-echocardiography-in-cardiogenic-embolic-cerebral-infarction
#9
Wen Chu, Hua Wang
Objective: To evaluate the diagnostic values of transesophageal echocardiography (TEE) and transthoracic echocardiography (TTE) in cardiogenic embolic cerebral infarction. Methods: Fifty patients with occult cerebral infarction who were admitted to the hospital between June 2015 and June 2016 were selected as research subjects. The patients were diagnosed by transesophageal echocardiography and transthoracic echocardiography. Diagnostic data were compared to analyze the values of the two diagnostic methods...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643873/gastric-emptying-scintigraphy-in-postprandial-distress-syndrome
#10
Muhammad Hafeez, Fida Hussain, Amjad Salamat, Muhammad Bilal Khan
Objective: To find out the pattern of gastric emptying scintigraphy (GES) in patients with post prandial distress syndrome (PDS). Methods: This study was carried out from January 2015 to July 2016 at Combined Military Hospital (CMH) Kharian and Nuclear Medical Centre (NMC) of Armed Forces Institute of Pathology (AFIP) Rawalpindi. Patient's inclusion criteria were dyspepsia of post prandial distress type for more than six months duration. Patients with dyspepsia due to epigastric pain syndrome and other organic disorder were excluded...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29642377/benzodiazepines-withdrawal-initial-outcomes-and-long-term-impact-on-falls-in-a-french-nursing-home
#11
Hervé Javelot, Anne Marquis, Emilie Antoine-Bernard, Jean Grandidier, Luisa Weiner, Thierry Javelot, Bruno Michel
Long-term use of benzodiazepines (BZDs) is known to induce tolerance and dependence, and increase the risk of falls-related injuries in older adults. We present a study carried out in a French nursing home that concerns the implementation of a BZD withdrawal program reassessed at one year. BZD deprescription was achieved by gradual cessation of doses. A secondary benefit of this program was assessed by comparing the number of falls among residents before and after withdrawal. The number of falls was recorded over a six-month period prior to the onset of withdrawal (T1) and then over a six-month period after reassessment at one year (T2)...
April 6, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29629856/use-of-genomics-to-design-a-diagnostic-assay-to-discriminate-between-streptococcus-pneumoniae-and-streptococcus-pseudopneumoniae
#12
Matthew A Croxen, Tracy D Lee, Robert Azana, Linda M Hoang
Distinuishing the species of mitis group streptococci is challenging due to ambiguous phenotypic characteristics and high degree of genetic similarity. This has been particularly true for resolving atypical Streptococcus pneumoniae and Streptococcus pseudopneumoniae. We used phylogenetic clustering to demonstrate specific and separate clades for both S. pneumoniae and S. pseudopneumoniae genomes. The genomes that clustered within these defined clades were used to extract species-specific genes from the pan-genome...
April 9, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29629510/endoscopic-ultrasound-guided-coil-or-glue-injection-in-post-cyanoacrylate-gastric-variceal-re-bleed
#13
Roy J Mukkada, Rajesh Antony, Mathew J Chooracken, Jose V Francis, Antony P Chettupuzha, Pradeep G Mathew, Philip Augustine, Abraham Koshy
BACKGROUND AND AIMS: N-butyl-cyanoacrylate injection is recommended in bleeding/recently bled gastric varices. However, cyanoacrylate injection is associated with re-bleed in 25% to 50% of patients. Endoscopic ultrasound (EUS)-guided coil application is an emerging treatment modality for bleeding gastric varices. The aim of this study was to compare EUS-guided coil application combined with or without cyanoacrylate glue injection to injection alone in post-glue gastric variceal re-bleed...
April 9, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29628171/-run-through-training-at-specialist-training-year-1-and-uncoupled-core-surgical-training-for-oral-and-maxillofacial-surgery-in-the-united-kingdom-a-snapshot-survey
#14
M Garg, J Collyer, D Dhariwal
Training in oral and maxillofacial surgery (OMFS) in the UK has undergone considerable changes during the last 10years, and "core" surgical training has replaced "basic" surgical training. In 2014 a pilot "run-through" training programme from specialist training year one (ST1)-ST7 was introduced to facilitate early entry into the speciality. Run-through training guarantees that a trainee, after a single competitive selection process and satisfactory progress, will be given training that covers the entire curriculum of the speciality, whereas uncoupled training requires a second stage of competitive recruitment after the first one (for OMFS only) or two years of "core" training to progress to higher specialty training...
April 5, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29627594/-you-stop-thinking-about-yourself-as-a-woman-an-interpretive-phenomenological-study-of-the-meaning-of-sexuality-for-icelandic-women-during-pregnancy-and-after-birth
#15
Sóley S Bender, Edda Sveinsdóttir, Hilda Fridfinnsdóttir
OBJECTIVE: There exists considerable evidence about reduced sexual desire and sexual disorders during pregnancy and after giving birth. More in-depth qualitative evidence is needed. The purpose of this study was to find out how Icelandic women experienced their sexuality during pregnancy and after giving birth. DESIGN/SETTING: An interpretive phenomenological study based on individual interviews with eight women was carried out at two time points, six and 12 months after giving birth, giving a total of 16 interviews...
March 22, 2018: Midwifery
https://www.readbyqxmd.com/read/29626847/crystal-structures-of-amyloidogenic-segments-of-human-transthyretin
#16
Lorena Saelices, Stuart A Sievers, Michael R Sawaya, David S Eisenberg
Amyloid diseases are characterized by the deposition of proteins in the form of amyloid fibrils, in organs that eventually fail. The development of effective drug candidates follows from the understanding of the molecular processes that lead to protein aggregation. Here we study amyloidogenic segments of transthyretin (TTR). TTR is a transporter of thyroxine and retinol in the blood and cerebrospinal fluid. When mutated and/or as a result of aging, TTR aggregates into amyloid fibrils that accumulate in organs such as the heart...
April 7, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29626665/ethiopian-highlands-as-a-cradle-of-the-african-fossorial-root-rats-genus-tachyoryctes-the-genetic-evidence
#17
Radim Šumbera, Jarmila Krásová, Leonid A Lavrenchenko, Sewnet Mengistu, Afework Bekele, Ondřej Mikula, Josef Bryja
Root-rats of the genus Tachyoryctes (Spalacidae) are subterranean herbivores occupying open humid habitats in the highlands of Eastern Africa. There is strong disagreement about species diversity of the genus, because some authors accept two species, while others more than ten. Species with relatively high surface activity, the giant root-rat Tachyoryctes macrocephalus, which is by far largest member of the genus, and the more fossorial African root-rat Tachyoryctes splendens, which eventually has been divided up to 12-13 species, represent two major morphological forms within the genus...
April 4, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29624623/motion-and-dural-sac-compression-in-the-upper-cervical-spine-during-the-application-of-a-cervical-collar-in-case-of-unstable-craniocervical-junction-a-study-in-two-new-cadaveric-trauma-models
#18
Shiyao Liao, Niko R E Schneider, Petra Hüttlin, Paul A Grützner, Frank Weilbacher, Stefan Matschke, Erik Popp, Michael Kreinest
BACKGROUND: Unstable conditions of the craniocervical junction such as atlanto-occipital dislocation (AOD) or atlanto-axial instability (AAI) are severe injuries with a high risk of tetraplegia or death. Immobilization by a cervical collar to protect the patient from secondary damage is a standard procedure in trauma patients. If the application of a cervical collar to a patient with an unstable craniocervical condition may cause segmental motion and secondary injury to the spinal cord is unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29623773/continuing-education-for-general-practitioners-working-in-rural-practice-a-review-of-the-literature
#19
Stephanie Dowling, Jason Last, Henry Finnigan, Walter Cullen
Background Studies demonstrate that the CME/CPD (continuing medical education/continuing professional development) needs of rural general practitioners (GPs) are unique. Little research has focused specifically on the effectiveness of CME/CPD programmes for rural practice. Aims To review the literature on CME/CPD for GPs in rural areas, focussing on studies which examined impact on doctor performance or patient outcomes. Methods A search of peer-reviewed English language literature and relevant grey literature was conducted: identified literature was reviewed...
April 6, 2018: Education for Primary Care
https://www.readbyqxmd.com/read/29621996/magnitude-and-factors-associated-with-adherence-to-iron-folic-acid-supplementation-among-pregnant-women-in-eritrean-refugee-camps-northern-ethiopia
#20
Mekdemariam Getachew, Mebrahtu Abay, Hiwet Zelalem, Tirhas Gebremedhin, Teklit Grum, Alemayehu Bayray
BACKGROUND: Globally, anemia is a public health problem affecting the life of more than two billion people. Pregnant women are at high risk of iron deficiency anemia due to increased nutrient requirement during pregnancy. Iron-folic acid supplementation is the main strategy for prevention and control of iron deficiency anemia and its effectiveness depends on adherence to Iron-Folic Acid tablets. In the refugee camps of Ethiopia, despite the efforts made to reduce iron deficiency anemia during pregnancy, information about adherence to iron-folic acid supplementation and its associated factors are lacking...
April 5, 2018: BMC Pregnancy and Childbirth
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