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https://www.readbyqxmd.com/read/28595097/neuropredictors-of-oromotor-feeding-impairment-in-12month-old-children
#1
Katherine Sanchez, Angela T Morgan, Justine M Slattery, Joy E Olsen, Katherine J Lee, Peter J Anderson, Deanne K Thompson, Lex W Doyle, Jeanie L Y Cheong, Alicia J Spittle
BACKGROUND: Feeding impairment is prevalent in children with neurodevelopmental issues. Neuroimaging and neurobehavioural outcomes at term are predictive of later neuromotor impairment, but it is unknown whether they predict feeding impairment. AIMS: To determine whether neurobehavior and brain magnetic resonance imaging (MRI) at term predict oromotor feeding at 12months in preterm and term-born children. STUDY DESIGN: Prospective cohort study...
June 5, 2017: Early Human Development
https://www.readbyqxmd.com/read/28527575/coup-tf-genes-human-diseases-and-the-development-of-the-central-nervous-system-in-murine-models
#2
Xiong Yang, Su Feng, Ke Tang
COUP-TFI and -TFII are members of the steroid/thyroid nuclear receptor superfamily. Recent clinical studies reveal that COUP-TFI gene mutations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome displaying symptoms of optic atrophy, intellectual disability, hypotonia, seizure, autism spectrum disorders, oromotor dysfunction, thin corpus callosum, or hearing defects, and COUP-TFII gene mutations lead to congenital heart defects and/or congenital diaphragmatic hernia with developmental delay and mental defects...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28499234/magnetic-implants-in-the-tongue-for-assistive-technologies-tests-of-migration-oromotor-function-and-tissue-response-in-miniature-pigs
#3
Alan J Sokoloff, Zhongtao Yang, Saman Sargolzaei, Karen Strait, Andrey Krasnopeyev, Kirk A Easley, Sylvie Mimche, Maysam Ghovanloo
OBJECTIVE: Uncertain biological consequences of titanium-magnet (Ti-mag) tongue implants constrain application of the Tongue Drive System (TDS), a brain-tongue-computer interface for individuals with severe physical impairment. Here we describe oromotor function and tongue tissue response following Ti-Mag implantation and explantation in the miniature pig, an animal model with a tongue similar in size to humans. DESIGN: A 1.8×6.2mm Ti-mag tracer was implanted into the anterior tongue in five Yucatan minipigs...
May 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28484358/anthropometric-parameters-of-nutritional-status-in-children-with-cerebral-palsy
#4
Melika Melunovic, Feriha Hadzagic-Catibusic, Vildan Bilalovic, Samra Rahmanovic, Selma Dizdar
INTRODUCTION: Patients with cerebral palsy (CP), besides the basic neurological damage, are also often undernourished. Adequate nutrition for children is very important during the period of intensive growth and development, which is of particular importance in patients with CP. GOAL: To evaluate the nutritional status of patients with CP who are treated at the Pediatric Clinic, Clinical Centre of Sarajevo University and causes of malnutrition in these patients. MATERIALS AND METHODS: Eighty patients with CP underwent anthropometric assessment (body weight, body height, body mass index, head circumference, subscapular skinfold thickness, triceps skinfold thickness and mid upper arm muscle circumference)...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28474131/dysphagia-in-friedreich-ataxia
#5
Megan J Keage, Martin B Delatycki, Isabelle Gupta, Louise A Corben, Adam P Vogel
The objective of the study was to comprehensively characterise dysphagia in Friedreich ataxia (FRDA) and identify predictors of penetration/aspiration during swallowing. We also investigated the psychosocial impact of dysphagia on individuals with FRDA. Sixty participants with FRDA were screened for dysphagia using a swallowing quality of life questionnaire (Swal-QOL) and case history. Individuals reporting dysphagia underwent a standardised oromotor assessment (Frenchay Dysarthria Assessment, 2, FDA-2) and videofluoroscopic study of swallowing (VFSS)...
May 4, 2017: Dysphagia
https://www.readbyqxmd.com/read/28444488/prophylactic-swallow-therapy-for-patients-with-head-and-neck-cancer-undergoing-chemoradiotherapy-a-randomized-trial
#6
Barbara Pisano Messing, Elizabeth C Ward, Cathy L Lazarus, Melissa Kim, Xian Zhou, Jessica Silinonte, Dorothy Gold, Karen Harrer, Karen Ulmer, Samantha Merritt, Geoffrey Neuner, Marshall Levine, Ray Blanco, John Saunders, Joseph Califano
Evidence supporting prophylactic swallow exercises for patients with head and neck cancer (HNC) has not been universally demonstrated. This RCT examined diet level, feeding tube use, swallow function, and quality of life (QOL) of patients undergoing chemoradiotherapy who performed prophylactic swallowing exercises. Sixty HNC patients were randomized into exercise versus control groups. Swallowing, oromotor, toxicity, and QOL data were recorded (baseline, 3, 6, 12, 24 months). Physiological swallow function was examined at baseline and 3 months...
April 25, 2017: Dysphagia
https://www.readbyqxmd.com/read/28411104/genetic-control-of-oromotor-phenotypes-a-survey-of-licking-and-ingestive-behaviors-in-highly-diverse-strains-of-mice
#7
Steven J St John, Lu Lu, Robert W Williams, Jennifer Saputra, John D Boughter
In order to examine genetic influences on fluid ingestion, 20-min intake of either water or 0.1M sucrose was measured in a lickometer in 18 isogenic strains of mice, including 15 inbred strains and 3 F1 hybrid crosses. Intake and licking data were examined at a number of levels, including lick rate as defined by mean or median interlick interval, as well as several microstructural parameters (i.e. burst-pause structure). In general, strain variation for ingestive phenotypes were correlated across water and sucrose in all strains, indicating fundamental, rather than stimulus-specific, mechanisms of intake...
April 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28218824/decreased-home-cage-movement-and-oromotor-impairments-in-adult-fmr1-ko-mice
#8
S J Bonasera, T R Chaudoin, E H Goulding, M Mittek, A Dunaevsky
Fragile X syndrome (FXS) is a common inherited disorder that significantly impacts family and patient day-to-day living across the entire life span. The childhood and adolescent behavioral consequences of FXS are well appreciated. However, there are significantly fewer studies (except those examining psychiatric comorbidities) assessing behavioral phenotypes seen in adults with FXS. Mice engineered with a genetic lesion of fragile X mental retardation 1 (Fmr1) recapitulate important molecular and neuroanatomical characteristics of FXS, and provide a means to evaluate adult behavioral phenotypes associated with FXS...
February 20, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28029056/ultrasound-in-dysphagia-rehabilitation-a-novel-approach-following-partial-glossectomy
#9
Katrina M Blyth, Patricia McCabe, Catherine Madill, Kirrie J Ballard
PURPOSE: While the presence of dysphagia following partial glossectomy has been widely reported, there is insufficient quality evidence to guide clinical decision making about the treatment of this disorder. This study investigated a novel dysphagia rehabilitation approach using ultrasound tongue imaging for patient training. METHOD: Initially, a pilot study was conducted to investigate the feasibility of ultrasound visual feedback during swallow tasks. The protocol was then replicated using a single-case experimental designed study to investigate therapeutic effect...
December 28, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27940755/lysine-restriction-and-pyridoxal-phosphate-administration-in-a-nadk2-patient
#10
Frederic Tort, Olatz Ugarteburu, Maria Angeles Torres, Judit García-Villoria, Marisa Girós, Angeles Ruiz, Antonia Ribes
We report the case of a 10-year-old Spanish girl with mutations in NADK2 Prenatal central nervous system abnormalities showed ventriculomegaly, colpocephaly, and hypoplasia of the corpus callosum. At birth, axial hypotonia, uncoordinated movements, microcephaly, and generalized cerebellar atrophy were detected. Metabolic investigations revealed high lysine, lactate, and pipecolic acid levels in blood and cerebrospinal fluid. Pyruvate carboxylase and pyruvate dehydrogenase activity in fibroblasts were normal...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27882295/neuroanatomical-correlates-of-childhood-apraxia-of-speech-a-connectomic-approach
#11
Simona Fiori, Andrea Guzzetta, Jhimli Mitra, Kerstin Pannek, Rosa Pasquariello, Paola Cipriani, Michela Tosetti, Giovanni Cioni, Stephen E Rose, Anna Chilosi
Childhood apraxia of speech (CAS) is a paediatric speech sound disorder in which precision and consistency of speech movements are impaired. Most children with idiopathic CAS have normal structural brain MRI. We hypothesize that children with CAS have altered structural connectivity in speech/language networks compared to controls and that these altered connections are related to functional speech/language measures. Whole brain probabilistic tractography, using constrained spherical deconvolution, was performed for connectome generation in 17 children with CAS and 10 age-matched controls...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27644167/oral-stimulation-for-promoting-oral-feeding-in-preterm-infants
#12
REVIEW
Zelda Greene, Colm Pf O'Donnell, Margaret Walshe
BACKGROUND: Preterm infants (< 37 weeks' postmenstrual age) are often delayed in attaining oral feeding. Normal oral feeding is suggested as an important outcome for the timing of discharge from the hospital and can be an early indicator of neuromotor integrity and developmental outcomes. A range of oral stimulation interventions may help infants to develop sucking and oromotor co-ordination, promoting earlier oral feeding and earlier hospital discharge. OBJECTIVES: To determine the effectiveness of oral stimulation interventions for attainment of oral feeding in preterm infants born before 37 weeks' postmenstrual age (PMA)...
September 20, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27609073/oromotor-feeding-in-children-born-before-30-weeks-gestation-and-term-born-peers-at-12-months-corrected-age
#13
Katherine Sanchez, Alicia J Spittle, Justine M Slattery, Angela T Morgan
OBJECTIVES: To evaluate oromotor feeding at 12 months' corrected age in children born before 30 weeks' gestational age compared with term-born peers by the use of observational assessment and to examine predictors of oromotor feeding difficulties in children born before 30 weeks. STUDY DESIGN: Oromotor feeding was assessed at 12 months' corrected age with the Schedule for Oral Motor Assessment in 90 children born before 30 weeks and 137 term-born children. Feeding outcomes were compared between groups...
November 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27570791/somatic-stimulation-causes-frontoparietal-cortical-changes-in-neonates-a-functional-near-infrared-spectroscopy-study
#14
Nasser H Kashou, Irfaan A Dar, Kathryn A Hasenstab, Ramzi W Nahhas, Sudarshan R Jadcherla
Palmar and plantar grasp are the foremost primitive neonatal reflexes and functions. Persistence of these reflexes in infancy is a sign of evolving cerebral palsy. Our aims were to establish measurement feasibility in a clinical setting and to characterize changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbD) concentration in the bilateral frontoparietal cortex in unsedated neonates at the crib-side using functional near-infrared spectroscopy (fNIRS). We hypothesized that bilateral concentration changes will occur upon somatic central and peripheral somatic stimulation...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/27537983/the-development-of-voiceless-sibilant-fricatives-in-putonghua-speaking-children
#15
Fangfang Li, Benjamin Munson
PURPOSE: The aims of the present study are (a) to quantify the developmental sequence of fricative mastery in Putonghua-speaking children and discuss the observed pattern in relation to existing theoretical positions, and (b) to describe the acquisition of the fine-articulatory/acoustic details of fricatives in the multidimensional acoustic space. METHOD: Twenty adults and 97 children participated in a speech-production experiment, repeating a list of fricative-initial words...
August 1, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/27511277/postoral-sugar-detection-rapidly-and-chemospecifically-modulates-taste-guided-behavior
#16
Lindsey A Schier, Alan Craig Spector
Several recent studies have shown that postoral sugar sensing rapidly stimulates ingestion. Here we explored the specificity with which early phase postoral sugar sensing influenced ingestive motivation. In Experiment 1, rats were trained to associate the consumption of 0.3M sucrose with injections of LiCl (3.0 mEq/kg IP, conditioned taste aversion) or given equivalent exposures to the stimuli, but in an unpaired fashion (UNPAIRED). Then, all rats were given two brief access tests to assess appetitive and consummatory responses to the taste properties of sucrose (0...
August 10, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27504264/atypical-benign-partial-epilepsy-of-childhood-with-acquired-neurocognitive-lexical-semantic-and-autistic-spectrum-disorder
#17
Nicholas M Allen, Judith Conroy, Thierry Deonna, Dara McCreary, Paul McGettigan, Cathy Madigan, Imogen Carter, Sean Ennis, Sally A Lynch, Amre Shahwan, Mary D King
Atypical benign partial epilepsy (ABPE) of childhood or pseudo-Lennox syndrome is a form of idiopathic focal epilepsy characterized by multiple seizure types, focal and/or generalized epileptiform discharges, continuous spike-wave during sleep (CSWS), and sometimes reversible neurocognitive deficits. There are few reported cases of ABPE describing detailed correlative longitudinal follow-up of the various associated neurocognitive, language, social communicative, or motor deficits, in parallel with the epilepsy...
2016: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27485389/effect-of-clonazepam-and-clonidine-on-primary-sleep-bruxism-a-double-blind-crossover-placebo-controlled-trial
#18
Takuro Sakai, Takafumi Kato, Shuichiro Yoshizawa, Takeshi Suganuma, Masayuki Takaba, Yasuhiro Ono, Ayako Yoshizawa, Yuya Yoshida, Tatsuya Kurihara, Masakazu Ishii, Fusae Kawana, Yuji Kiuchi, Kazuyoshi Baba
The aim of this study was to assess the acute effects of clonazepam and clonidine on rhythmic masticatory muscle activity in young adults with primary sleep bruxism, as well as accompanying effects on sleep architecture and cardiac activity. This study used a double-blind, crossover, placebo-controlled design. Polysomnography was performed on 19 subjects [nine men and 10 women; mean age (±SE): 25.4 ± 2.7 years] for 5 nights. The first 2 nights were used for the habituation and diagnosis of sleep bruxism...
February 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/27445144/supratrigeminal-bilaterally-projecting-neurons-maintain-basal-tone-and-enable-bilateral-phasic-activation-of-jaw-closing-muscles
#19
Edward Stanek, Erica Rodriguez, Shengli Zhao, Bao-Xia Han, Fan Wang
UNLABELLED: Anatomical studies have identified brainstem neurons that project bilaterally to left and right oromotor pools, which could potentially mediate bilateral muscle coordination. We use retrograde lentiviruses combined with a split-intein-mediated split-Cre-recombinase system in mice to isolate, characterize, and manipulate a population of neurons projecting to both the left and right jaw-closing trigeminal motoneurons. We find that these bilaterally projecting premotor neurons (BPNs) reside primarily in the supratrigeminal nucleus (SupV) and the parvicellular and intermediate reticular regions dorsal to the facial motor nucleus...
July 20, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27372362/swallowing-characteristics-in-amyotrophic-lateral-sclerosis
#20
Mansi Pankaj Jani, Geeta Bharat Gore
BACKGROUND: Motor neurone disease also commonly known as Amyotrophic Lateral Sclerosis (ALS) is a neurological condition which affects various motor functions of the body. Dysphagia (disordered swallowing) is commonly seen in patients with ALS having bulbar symptoms. OBJECTIVES: Research reveals presence of dysphagia in patients with ALS at various stages of swallowing using instrumental assessment. However, very few studies have been done focussing on clinical profiling of swallowing in these patients...
June 27, 2016: NeuroRehabilitation
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