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Gugging screening

Simon Fandler, Thomas Gattringer, Sebastian Eppinger, Kathrin Doppelhofer, Daniela Pinter, Kurt Niederkorn, Christian Enzinger, Joanna M Wardlaw, Franz Fazekas
BACKGROUND AND PURPOSE: Detailed data on the occurrence of swallowing dysfunction in patients with recent small subcortical infarcts (RSSI) in the context of cerebral small vessel disease are lacking. This prompted us to assess the frequency of and risk factors for dysphagia in RSSI patients. METHODS: We identified all inpatients with magnetic resonance imaging-confirmed RSSI between January 2008 and February 2013. Demographic and clinical data were extracted from our stroke database, and magnetic resonance imaging scans were reviewed for morphological changes...
January 2017: Stroke; a Journal of Cerebral Circulation
N M Giannantoni, M Minisci, V Brunetti, E Scarano, E Testani, C Vollono, E De Corso, G Bastanza, L D'Alatri, G Della Marca
Oro-pharyngeal dysphagia is frequently present during the acute phase of stroke. The aim of the present study was to evaluate whether the recording of surface EMG using a nasopharyngeal (NP) electrode could be applied to evaluation of pharyngeal muscle activity in acute stroke patients and if this neurophysiological measure is related with clinical assessment of swallowing. Patients were examined and clinical severity was assessed with the National Institute of Health Stroke Scale (NIHSS) score; dysphagia was evaluated through bedside screening test using the Gugging Swallowing Scale (GUSS)...
August 2016: Acta Otorhinolaryngologica Italica
Aline Mansueto Mourão, Stela Maris Aguiar Lemos, Erica Oliveira Almeida, Laélia Cristina Caseiro Vicente, Antonio Lúcio Teixeira
PURPOSE: To investigate the frequency of dysphagia in acute stroke and the possible associated clinical and sociodemographic features. METHOD: A cross-sectional study was performed including 100 stroke patients who were admitted to the Minas Gerais Regional Public Hospital. Sociodemographic and clinical data were collected, and the patients underwent clinical evaluation through the Gugging Swallowing Screen (GUSS). RESULTS: The frequency of dysphagia was 50%, and most patients had severe swallowing disorders...
January 2016: CoDAS
Marcel Arnold, Kai Liesirova, Anne Broeg-Morvay, Julia Meisterernst, Markus Schlager, Marie-Luise Mono, Marwan El-Koussy, Georg Kägi, Simon Jung, Hakan Sarikaya
BACKGROUND: Reported frequency of post-stroke dysphagia in the literature is highly variable. In view of progress in stroke management, we aimed to assess the current burden of dysphagia in acute ischemic stroke. METHODS: We studied 570 consecutive patients treated in a tertiary stroke center. Dysphagia was evaluated by using the Gugging Swallowing Screen (GUSS). We investigated the relationship of dysphagia with pneumonia, length of hospital stay and discharge destination and compared rates of favourable clinical outcome and mortality at 3 months between dysphagic patients and those without dysphagia...
2016: PloS One
Yeon-Hwan Park, Hwal Lan Bang, Hae-Ra Han, Hee-Kyung Chang
PURPOSE: The purpose of this study was to evaluate the psychometric quality and feasibility of measurements for screening dysphagia in older adults to identify the 'right tool' for nurses to use in nursing homes. METHODS: A systematic review was done. Electronic databases were searched for studies related to dysphagia screening measurements. A checklist was used to evaluate the psychometric quality and applicability. Tools were evaluated for feasible incorporation into routine care by nurses...
February 2015: Journal of Korean Academy of Nursing
Jennilee St John, Linley Berger
Aspiration pneumonia from dysphagia following stroke presents significant morbidity and mortality in that population. Dysphagia screening before oral intake has been a standard of care for years, but there is a lack of consensus on the best screening tool. The Gugging Swallowing Screen (GUSS) is presented as a potentially better alternative to other dysphagia screens due to its safer progression of oral intake, more thorough evaluation of swallowing, and ability to enable earlier nutrition.
March 2015: Journal of Continuing Education in Nursing
Swapna Sebastian, Prem G Nair, Philip Thomas, Amit Kumar Tyagi
To determine the type, severity and manifestation of dysphagia in patients with neurogenic etiology. Clinical documentation was done on the different etiologies, its manifestation, assessment findings and management strategies taken for patients with neurogenic oropharyngeal dysphagia who were referred for assessment and management of dysphagia over a period of three months in a tertiary care teaching hospital. Flexible endoscopic examination was done in all the patients. The severity of dysphagia in these patients were graded based on Gugging Swallowing Screen (GUSS)...
March 2015: Indian Journal of Otolaryngology and Head and Neck Surgery
Sun Haeng Lee, Byeong-Yeon Moon, Hyun Gug Cho
[Purpose] To determine whether the improvement of vergence movements by vision therapy can decrease the K-ARS scores of symptomatic ADHD children. [Methods] Eighty-one out of 1,123 children surveyed using the K-ARS, a parents'-reported questionnaire, led to 16 of these 81 children being showed scores of ≥19, and measurement of binocular function diagnosed as having convergence insufficiency. The 16 children were divided equally into a control group and a vision therapy group. [Results] After vision therapy for 12 weeks, near point convergence (4...
February 2014: Journal of Physical Therapy Science
Yeon-Hwan Park, Hae-Ra Han, Seieun Oh, HeeKyung Chang
Proper management and prevention of dysphagia is an urgent need of long-term care for older adults in Korea. However, no screening tools with high sensitivity and accessibility have been validated within Korean nursing home settings. The purpose of this study was to validate a screening tool for nurses to identify dysphagia and aspiration risk in nursing home residents. RNs screened 395 residents from two nursing homes in South Korea using the Korean version of the Standardized Swallowing Assessment (K-SSA)...
February 2014: Journal of Gerontological Nursing
L E García Rojas Vázquez, L A Trujano-Ramos, E Pérez-Rivera
UNLABELLED: The head and neck cancer in Michoacán, Mexico, ranks as the third most common cancer and accounts for 12% of deaths. The increase in malnutrition in a patient with this disease has been associated with increased mortality. MATERIAL AND METHODS: We studied prospectively 30 patients of both sexes, aged 18 years with head and neck cancer in the Cancer Care Center of Michoacan. In the evaluation period since August 2010 to August 2011. Formats were used VGS-Oncology (Subjective Global Assessment), NRS 2002 (Nutritional risk screen) and Guss (Gugging Swallowing Screen), through which nutritional risk was determined, and established the swallowing capacity of the study population...
September 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Sanghee Kim, Youngsoon Byeon
BACKGROUND: Feeding methods for patients with acute stroke differ based on their ability to swallow; therefore, it is necessary to determine whether these methods deliver enough nourishment to these patients. Although nutrition could affect recovery from acute stroke, it is often overlooked. Indicators of nutritional status are important for the nutritional assessment of patients. PURPOSE: The purpose of this study was to compare changes in nutritional indicators with various feeding methods in patients with acute stroke...
April 2014: Nutritional Neuroscience
Rikke Terp Sørensen, Rune Skovgaard Rasmussen, Karsten Overgaard, Axel Lerche, Ann Mosegaard Johansen, Tove Lindhardt
OBJECTIVES: Dysphagia occurs in approximately 51%-78% of patients with acute stroke. The incidence of pneumonia caused by aspiration in dysphagic patients increases both mortality and the need for hospitalization. The aim of this study was to investigate whether the incidence of aspiration pneumonia could be reduced in such patients by an early screening for dysphagia and intensified oral hygiene. MATERIAL AND METHODS: In this controlled trial, 146 hospitalized acute stroke patients with moderate or severe dysphagia were included in three groups: an intervention group (n = 58), one internal control group (n = 58, retrospectively selected from same clinic), and one external control group (n = 30) from a comparable stroke unit in a neighboring hospital...
June 2013: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Yeon-Hwan Park, Hae-Ra Han, Byung-Mo Oh, Jinyi Lee, Ji-ae Park, Su Jeong Yu, HeeKyung Chang
Dysphagia is a major health care problem in nursing homes. It can lead to fatal complications including aspiration pneumonia and even death. The aims of this study were to evaluate the prevalence of dysphagia in nursing home residents in South Korea and to identify factors associated with dysphagia. The study was conducted in two urban nursing homes and a total of 395 older adults (aged 65-103 years old, 76.5% female) were enrolled. The presence of dysphagia was evaluated using the Gugging Swallowing Screen (GUSS) test...
May 2013: Geriatric Nursing
Tyrone Bowes, Shirley A Hanley, Aaron Liew, Marc Eglon, Kaveh Mashayekhi, Richard O'Kennedy, Frank Barry, W Robert Taylor, Timothy O'Brien, Matthew D Griffin, William J J Finlay, Udo Greiser
This study aims at generating immune chicken phage display libraries and single-chain antibodies (scFvs) specifically directed against cell surface markers of cultured peripheral blood mononuclear cells (PBMCs) that contain endothelial progenitor cells (EPCs). In contrast to previous approaches that use well-defined recombinant antigens attached to plastic surfaces that may alter the structure of the proteins, the authors describe a method that maintains the cell surface markers on live cells while providing the opportunity to rapidly screen entire libraries for antibodies that bind to unknown cell surface markers of progenitor/stem cells...
August 2011: Journal of Biomolecular Screening
Déborah Tribouillard, Fabienne Gug, Hervé Galons, Stéphane Bach, Sven J Saupe, Marc Blondel
A number of drugs active against prions either in vitro, in cellular systems or in vivo in animal models have been isolated in various screening assays. In this minireview, we would like to suggest, that in addition to their direct interest as potential therapeutic agents, these molecules could be used as original research tools to understand prion propagation. The use of antiprion compounds as tool to understand fundamentals of prion propagation relies on reverse screening approaches. These global genetic and/or biochemical approaches aim to identify the intracellular target(s) and mechanism of action of the drugs...
January 2007: Prion
Déborah Tribouillard-Tanvier, Vincent Béringue, Nathalie Desban, Fabienne Gug, Stéphane Bach, Cécile Voisset, Hervé Galons, Hubert Laude, Didier Vilette, Marc Blondel
BACKGROUND: Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans. METHODOLOGY/PRINCIPAL FINDINGS: Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely used in human medicine as an antihypertensive drug. We isolated GA in a screen for drugs active in vivo against two different yeast prions using a previously described yeast-based two steps assay...
2008: PloS One
Michaela Trapl, Paul Enderle, Monika Nowotny, Yvonne Teuschl, Karl Matz, Alexandra Dachenhausen, Michael Brainin
BACKGROUND AND PURPOSE: Acute-onset dysphagia after stroke is frequently associated with an increased risk of aspiration pneumonia. Because most screening tools are complex and biased toward fluid swallowing, we developed a simple, stepwise bedside screen that allows a graded rating with separate evaluations for nonfluid and fluid nutrition starting with nonfluid textures. The Gugging Swallowing Screen (GUSS) aims at reducing the risk of aspiration during the test to a minimum; it assesses the severity of aspiration risk and recommends a special diet accordingly...
November 2007: Stroke; a Journal of Cerebral Circulation
Déborah Tribouillard, Stéphane Bach, Fabienne Gug, Nathalie Desban, Vincent Beringue, Thibault Andrieu, Dominique Dormont, Hervé Galons, Hubert Laude, Didier Vilette, Marc Blondel
Prions are misfolded proteins capable of propagating their altered conformation which are commonly considered as the causative agent of transmissible spongiform encephalopathies, a class of fatal neurodegenerative diseases. Currently, no treatment for prion-based diseases is available. Recently we have developed a rapid, yeast-based, two-step assay to screen for anti-prion drugs [1]. This new method allowed us to identify several compounds that are effective in vivo against budding yeast [PSI+] and [URE3] prions but also able to promote mammalian prion clearance in three different cell culture-based assays...
January 2006: Biotechnology Journal
G Rádis-Baptista, N Oguiura, M A Hayashi, M E Camargo, K F Grego, E B Oliveira, T Yamane
A cDNA phage library was constructed from venom glands of a single adult specimen of crotamine-plus Crotalus durissus terrificus (South American rattlesnake) captured in a known region. Fifteen crotamine positive clones were isolated using a PCR-based screening protocol and sequenced. These complete cDNAs clones were grouped for maximal alignment into six distinct nucleotide sequences. The crotamine cDNAs, with 340-360 bases, encompass open reading frame of 198 nucleotides with 5' and 3' untranslated regions of variable size, signal peptide sequence, one crotamine isoform message, and putative poly(A+) signal...
July 1999: Toxicon: Official Journal of the International Society on Toxinology
J K Sussman, E L Simons, R W Simons
In a genetic selection designed to isolate Escherichia coli mutations that increase expression of the IS 10 transposase gene (tnp), we unexpectedly obtained viable mutants defective in translation initiation factor 3 (IF3). Several lines of evidence led us to conclude that transposase expression, per se, was not increased. Rather, these mutations appear to increase expression of the tnp'-'lacZ gene fusions used in this screen, by increasing translation initiation at downstream, atypical initiation codons. To test this hypothesis we undertook a systematic analysis of start codon requirements and measured the effects of IF3 mutations on initiation from various start codons...
July 1996: Molecular Microbiology
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