keyword
https://read.qxmd.com/read/35763667/targeted-radiotherapy-for-early-stage-low-risk-pediatric-hodgkin-lymphoma-slow-early-responders-a-cog-ahod0431-analysis
#21
JOURNAL ARTICLE
Akash Parekh, Frank G Keller, Kathleen M McCarten, Sandy Kessel, Steve Cho, Qinglin Pei, Yue Wu, Sharon M Castellino, Louis S Constine, Cindy L Schwartz, David Hodgson, Kara M Kelly, Bradford S Hoppe
Children's Oncology Group trial AHOD0431 reduced systemic therapy and used response-adapted involved-field radiotherapy (IFRT) in early-stage pediatric classical Hodgkin lymphoma. We investigated the impact of PET response after 1 cycle (PET1) and IFRT on outcomes and relapse pattern. Patients on AHOD 0431 underwent PET1 response assessment after AVPC (doxorubicin, vincristine, prednisone, and cyclophosphamide). "Rapid early responders" (RER) had a negative PET1; "slow early responders" (SER) had a positive PET1...
June 28, 2022: Blood
https://read.qxmd.com/read/35745286/in-vitro-high-throughput-toxicological-assessment-of-nanoplastics
#22
JOURNAL ARTICLE
Valentina Tolardo, Davide Magrì, Francesco Fumagalli, Domenico Cassano, Athanassia Athanassiou, Despina Fragouli, Sabrina Gioria
Sub-micrometer particles derived from the fragmentation of plastics in the environment can enter the food chain and reach humans, posing significant health risks. To date, there is a lack of adequate toxicological assessment of the effects of nanoplastics (NPs) in mammalian systems, particularly in humans. In this work, we evaluated the potential toxic effects of three different NPs in vitro: two NPs obtained by laser ablation (polycarbonate (PC) and polyethylene terephthalate (PET1)) and one (PET2) produced by nanoprecipitation...
June 7, 2022: Nanomaterials
https://read.qxmd.com/read/35624030/transcriptional-preservation-of-serotonergic-connectivity-may-shed-light-on-neurodegeneration
#23
JOURNAL ARTICLE
Mariano Soiza-Reilly
In a recent study, Kitt, Tabuchi, and colleagues unveiled a novel function of an early-stage transcriptional network to maintain the adult integrity of serotonergic connectivity. Reported axonal and synaptic morphological alterations in serotonin (5-HT) neurons after selective inactivation of Lmx1b/Pet1 transcriptional networks may help to understand aging and neurodegenerative processes.
May 24, 2022: Trends in Neurosciences
https://read.qxmd.com/read/35489678/transferability-of-esbl-encoding-incn-and-inci1-plasmids-among-field-strains-of-different-salmonella-serovars-and-escherichia-coli
#24
JOURNAL ARTICLE
Mackenzie Dorr, Aryeh Silver, Dylan Smurlick, Ananta Arukha, Subhashinie Kariyawasam, Adelumola Oladeinde, Kimberly Cook, Thomas Denagamage
OBJECTIVES: This study aimed to sequence, assemble, and annotate three plasmids (two IncN and one IncI1) carrying the blaCTX-M-1 gene and assess their transferability rates between homologous and heterologous serovars and/or species of bacteria. METHODS: First, the plasmids were sequenced, assembled, and annotated. They were then transferred from three donor strains (Escherichia coli/IncN, S. Heidelberg/IncN, and S. Heidelberg/IncI1) into nine recipient strains (S...
September 2022: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/35471146/reorganization-of-postmitotic-neuronal-chromatin-accessibility-for-maturation-of-serotonergic-identity
#25
JOURNAL ARTICLE
Xinrui L Zhang, William C Spencer, Nobuko Tabuchi, Meagan M Kitt, Evan S Deneris
Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin. Yet, the mechanisms controlling postmitotic neuronal chromatin accessibility are poorly understood. Here, we show that unique distal enhancers define the Pet1 neuron lineage that generates serotonin (5-HT) neurons in mice. Heterogeneous single cell chromatin landscapes are established early in postmitotic Pet1 neurons and reveal the putative regulatory programs driving Pet1 neuron subtype identities...
April 26, 2022: ELife
https://read.qxmd.com/read/35443166/an-adult-stage-transcriptional-program-for-survival-of-serotonergic-connectivity
#26
JOURNAL ARTICLE
Meagan M Kitt, Nobuko Tabuchi, W Clay Spencer, Heath L Robinson, Xinrui L Zhang, Brent A Eastman, Katherine J Lobur, Jerry Silver, Lin Mei, Evan S Deneris
Neurons must function for decades of life, but how these non-dividing cells are preserved is poorly understood. Using mouse serotonin (5-HT) neurons as a model, we report an adult-stage transcriptional program specialized to ensure the preservation of neuronal connectivity. We uncover a switch in Lmx1b and Pet1 transcription factor function from controlling embryonic axonal growth to sustaining a transcriptomic signature of 5-HT connectivity comprising functionally diverse synaptic and axonal genes. Adult-stage deficiency of Lmx1b and Pet1 causes slowly progressing degeneration of 5-HT synapses and axons, increased susceptibility of 5-HT axons to neurotoxic injury, and abnormal stress responses...
April 19, 2022: Cell Reports
https://read.qxmd.com/read/35328019/kasp-markers-specific-for-the-fertility-restorer-locus-rf1-and-application-for-genetic-purity-testing-in-sunflowers-helianthus-annuus-l
#27
JOURNAL ARTICLE
Aleksandra Radanović, Yves Sprycha, Milan Jocković, Monja Sundt, Dragana Miladinović, Constantin Jansen, Renate Horn
Single nucleotide polymorphisms (SNPs) were significantly associated with fertility restoration of cytoplasmic male sterility (CMS) PET1 by the restorer gene Rf1 . For these SNPs, four Kompetitive allele-specific PCR (KASP) markers were successfully designed. The KASP markers cover the fertility restorer locus Rf1 , spanning about 3 Mb, and clearly differentiate restorer and maintainer lines. For genetic purity testing in sunflower hybrid production, the efficiency for detecting contaminations in samples was simulated using mixtures of hypocotyls or leaves...
March 5, 2022: Genes
https://read.qxmd.com/read/35073166/first-extensive-analysis-of-18-f-labeled-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-a-large-cohort-of-patients-with-hiv-associated-hodgkin-lymphoma-baseline-total-metabolic-tumor-volume-affects-prognosis
#28
JOURNAL ARTICLE
Nicolas Louarn, Lionel Galicier, Rémi Bertinchamp, David Lussato, Françoise Montravers, Éric Oksenhendler, Pascal Merlet, Laurence Gérard, Laetitia Vercellino
PURPOSE: 18 F-labeled fluorodeoxyglucose positron emission tomography with computed tomography (18 F-FDG PET-CT) data in HIV-associated Hodgkin lymphoma (HIV-HL) are scarcely reported. In addition to the description of the characteristics of both baseline and interim 18 F-FDG PET-CT examinations (PET1 and iPET, respectively), the aim of this study was to assess the prognostic value of PET1 and previously identified clinical parameters in this population. PATIENTS AND METHODS: PET1 of 109 patients with HIV-HL, treated with doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy regimen since 2007, and 104 iPET were centrally reviewed...
April 20, 2022: Journal of Clinical Oncology
https://read.qxmd.com/read/34957103/developmental-disruption-of-erbb4-in-pet1-neurons-impairs-serotonergic-sub-system-connectivity-and-memory-formation
#29
JOURNAL ARTICLE
Candela Barettino, Álvaro Ballesteros-Gonzalez, Andrés Aylón, Xavier Soler-Sanchis, Leticia Ortí, Selene Díaz, Isabel Reillo, Francisco García-García, Francisco José Iborra, Cary Lai, Nathalie Dehorter, Xavier Leinekugel, Nuria Flames, Isabel Del Pino
The serotonergic system of mammals innervates virtually all the central nervous system and regulates a broad spectrum of behavioral and physiological functions. In mammals, serotonergic neurons located in the rostral raphe nuclei encompass diverse sub-systems characterized by specific circuitry and functional features. Substantial evidence suggest that functional diversity of serotonergic circuits has a molecular and connectivity basis. However, the landscape of intrinsic developmental mechanisms guiding the formation of serotonergic sub-systems is unclear...
2021: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/34829324/prediction-of-neoadjuvant-chemotherapy-response-in-osteosarcoma-using-convolutional-neural-network-of-tumor-center-18-f-fdg-pet-images
#30
JOURNAL ARTICLE
Jingyu Kim, Su Young Jeong, Byung-Chul Kim, Byung-Hyun Byun, Ilhan Lim, Chang-Bae Kong, Won Seok Song, Sang Moo Lim, Sang-Keun Woo
We compared the accuracy of prediction of the response to neoadjuvant chemotherapy (NAC) in osteosarcoma patients between machine learning approaches of whole tumor utilizing fluorine-18 fluorodeoxyglucose (18 F-FDG) uptake heterogeneity features and a convolutional neural network of the intratumor image region. In 105 patients with osteosarcoma, 18 F-FDG positron emission tomography/computed tomography (PET/CT) images were acquired before (baseline PET0) and after NAC (PET1). Patients were divided into responders and non-responders about neoadjuvant chemotherapy...
October 25, 2021: Diagnostics
https://read.qxmd.com/read/34750067/genes-involved-in-paediatric-apnoea-and-death-based-on-knockout-animal-models-implications-for-sudden-infant-death-syndrome-sids
#31
REVIEW
Eliza Stalley, Karen A Waters, Rita Machaalani
The mechanism of death in Sudden infant death syndrome (SIDS) remains unknown but it is hypothesised that cardiorespiratory failure of brainstem origin results in early post-natal death. For a subset of SIDS infants, an underlying genetic cause may be present, and genetic abnormalities affecting brainstem respiratory control may result in abnormalities that are detectable before death. Genetic knockout mice models were developed in the 1990s and have since helped to elucidate the physiological roles of a number of genes...
December 2022: Paediatric Respiratory Reviews
https://read.qxmd.com/read/34700671/feasibility-of-using-fdg-in-the-stereotactic-ablative-setting-for-tracked-dose-delivery-with-bgrt-results-from-a-prospective-study-of-serial-inter-fraction-pet-cts
#32
JOURNAL ARTICLE
A Da Silva, P Olcott, S Tian, X Yang, I Sethi, S M Shirvani, S Mazin, T K Owonikoko, J D Bradley, D M Schuster, K A Higgins
PURPOSE/OBJECTIVE(S): Biology-guided radiotherapy (BgRT) is a new radiation modality that utilizes real-time limited time sampled FDG PET images of a tumor to deliver a dynamically tracked dose distribution. Since the delivered radiotherapy dose is dependent on the FDG distribution at each fraction, the ability to deliver the planned dose despite variations in daily FDG signal must be established. This study evaluates the predicted dose distribution for BgRT based on serial FDG scans obtained over a course of stereotactic ablative radiotherapy (SABR)...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/34593596/-18-f-flt-pet-ct-as-a-prognostic-imaging-biomarker-of-disease-specific-survival-in-patients-with-primary-soft-tissue-sarcoma
#33
JOURNAL ARTICLE
Joseph Crompton, Wesley R Armstrong, Mark A Eckardt, Ameen Seyedroudbari, William D Tap, Sarah M Dry, Evan R Abt, Jeremie Calais, Ken Herrmann, Johannes Czernin, Fritz C Eilber, Matthias R Benz
Purpose: The purpose of this study was to evaluate 18 F-FLT PET/CT as an early prognostic imaging biomarker of long-term overall survival (OS) and disease-specific survival (DSS) in soft tissue sarcoma (STS) patients treated with neoadjuvant therapy (NAT) and surgical resection. Methods: This is a 10-year follow up of a previous, single-center, single-arm, prospective clinical trial. Patients underwent 18 F-FLT PET/CT prior to treatment (PET1) and after NAT (PET2). Post-treatment pathology specimens were assessed for tumor necrosis / fibrosis as well as Ki-67 and TK1 expression...
September 30, 2021: Journal of Nuclear Medicine
https://read.qxmd.com/read/34565612/neuronal-pericellular-baskets-neurotransmitter-convergence-and-regulation-of-network-excitability
#34
REVIEW
Rebecca A Senft, Susan M Dymecki
A pericellular basket is a presynaptic configuration of numerous axonal boutons outlining a target neuron soma and its proximal dendrites. Recent studies show neurochemical diversity of pericellular baskets and suggest that neurotransmitter usage together with the dense, soma-proximal boutons may permit strong input effects on different timescales. Here we review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. As an example, we highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei...
November 2021: Trends in Neurosciences
https://read.qxmd.com/read/34485345/-18-f-fdg-positron-emission-tomography-for-initial-staging-and-healing-assessment-at-the-end-of-therapy-in-lymph-nodes-and-bone-tuberculosis
#35
JOURNAL ARTICLE
Laure Sarda-Mantel, Jidar Kaoutar, Toni Alfaiate, Amanda Lopes, Frédéric Paycha, Khadija Benali, Nidaa Mikail, Michael Soussan, Charles Lemarignier, Frédéric Méchaï, Sophie Le Nagat, Françoise Montravers, Ouda Deradji, Emmanuel Durand, Tiphaine Goulenok, Diane Ponscarme, Patrick Yéni, Cédric Laouénan, Christophe Rioux
Objective: In extra-pulmonary tuberculosis, therapeutic management is difficult in the absence of reliable tool to affirm healing at the end of treatment. In this prospective multicenter study, we evaluated [18 F]FDG-PET for this purpose. Methods: Forty-two patients out of 55 included patients could be analyzed. Additionally to usual biological, histological and morphological explorations, [18 F]FDG-PET was performed at diagnosis (PET1), at the end of treatment (PET2), indeed 6 months later. Then patients were followed until 12 months after end of prescribed treatment...
2021: Frontiers in Medicine
https://read.qxmd.com/read/34424870/evaluation-of-68ga-ga-psma-pet-ct-for-therapy-response-assessment-of-177lu-lu-psma-radioligand-therapy-in-metastasized-castration-refractory-prostate-cancer-and-correlation-with-survival
#36
JOURNAL ARTICLE
Jens Kurth, Justus Kretzschmar, Hamzeh Aladwan, Martin Heuschkel, Anja Gummesson, Carina Bergner, Günther Kundt, Oliver W Hakenberg, Bernd J Krause, Sarah M Schwarzenböck
PURPOSE: The aim of this retrospective study was to evaluate the use of [68Ga]Ga-PSMA PET/CT in therapy response assessment (TRA) of mCRPC patients treated with [177Lu]Lu-PSMA-617 and its correlation with overall survival (OS). METHODS: Thirty-nine patients were included in the study. Patient-/lesion-based early and late response assessment (ERA/LRA) was defined as PET2 (after two therapy cycles) vs. PET1 (before the first cycle) (n = 29) and end of treatment PET vs...
May 19, 2021: Nuclear Medicine Communications
https://read.qxmd.com/read/34272317/18f-fdg-pet-ct-imaging-biomarkers-for-early-and-late-evaluation-of-response-to-first-line-chemotherapy-in-patients-with-pancreatic-ductal-adenocarcinoma
#37
JOURNAL ARTICLE
Matthias R Benz, Wesley R Armstrong, Francesco Ceci, Giulia Polverari, Timothy R Donahue, Zev A Wainberg, Andrew Quon, Martin Auerbach, Mark D Girgis, Ken Herrmann, Johannes Czernin, Jeremie Calais
The purpose of this study was to evaluate 18 F-FDG PET/CT as an early and late interim imaging biomarker in patients with pancreatic ductal adenocarcinoma who undergo first-line systemic therapy. Methods: This was a prospective, single-center, single-arm, open-label study (IRB12-000770). Patient receiving first-line chemotherapy were planned to undergo baseline 18 F-FDG PET/CT, early interim 18 F-FDG PET/CT, and late interim 18 F-FDG PET/CT. Cutoffs for metabolic and radiographic tumor response assessment as selected and established by receiver-operating-characteristic analysis were applied (modified PERCIST/RECIST1...
February 2022: Journal of Nuclear Medicine
https://read.qxmd.com/read/33944897/optimal-timing-and-criteria-of-interim-pet-in-dlbcl-a-comparative-study-of-1692-patients
#38
JOURNAL ARTICLE
J J Eertink, C N Burggraaff, M W Heymans, U Dührsen, A Hüttmann, C Schmitz, S Müller, P J Lugtenburg, S F Barrington, N G Mikhaeel, R Carr, S Czibor, T Györke, L Ceriani, E Zucca, M Hutchings, L Kostakoglu, A Loft, S Fanti, S E Wiegers, S Pieplenbosch, R Boellaard, O S Hoekstra, J M Zijlstra, H C W de Vet
Interim 18F-fluorodeoxyglucose positron emission tomography (Interim-18F-FDG-PET, hereafter I-PET) has the potential to guide treatment of patients with diffuse large B-cell lymphoma (DLBCL) if the prognostic value is known. The aim of this study was to determine the optimal timing and response criteria for evaluating prognosis with I-PET in DLBCL. Individual patient data from 1692 patients with de novo DLBCL were combined and scans were harmonized. I-PET was performed at various time points during treatment with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy...
May 11, 2021: Blood Advances
https://read.qxmd.com/read/33727585/dorsal-raphe-serotonin-neurotransmission-is-required-for-the-expression-of-nursing-behavior-and-for-pup-survival
#39
JOURNAL ARTICLE
Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspar
Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO...
March 16, 2021: Scientific Reports
https://read.qxmd.com/read/33715090/-18-f-fdg-pet-ct-quantitative-parameters-for-the-prediction-of-histological-response-to-induction-chemotherapy-and-clinical-outcome-in-patients-with-localised-bone-and-soft-tissue-ewing-sarcoma
#40
JOURNAL ARTICLE
Alessio Annovazzi, Virginia Ferraresi, Vincenzo Anelli, Renato Covello, Sabrina Vari, Carmine Zoccali, Roberto Biagini, Rosa Sciuto
OBJECTIVE: The application of [18 F]FDG PET/CT in predicting histologic response to induction chemotherapy in patients with Ewing sarcoma (EWS) has been proposed using the values of pre-post treatment SUVmax as a referral parameter, although with heterogeneous results. The aim of this retrospective study was to evaluate the diagnostic accuracy of [18 F]FDG PET/CT volumetric parameters (metabolic tumour volume (MTV) and total lesion glycolysis (TLG)) as compared to SUVmax to predict response to chemotherapy and clinical outcome in patients with localised EWS of bone and soft-tissue...
September 2021: European Radiology
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