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https://www.readbyqxmd.com/read/29926063/-serotonergic-neurons-in-the-median-raphe-nucleus-mediate-anxiety-and-depression-like-behavior
#1
Shuang Li, Wen-Qing Yao, Ye-Zheng Tao, Lan Ma, Xing Liu
Serotonin (5-hydroxtryptamine, 5-HT), one of the central neurotransmitters, is the most important modulator for emotion regulation, sensory processing, cognitive control, etc. The serotonergic neurons are limited in amount and mainly distributed in the dorsal raphe nucleus (DR) and the median raphe nucleus (MR) in the midline of the brain stem. Previous studies mainly focused on the function of 5-HT neurons in the DR, but little is known about 5-HT neurons in MR. In the present study, with Pet1-Cre transgenic mice and DREADDs technology, we specifically activated or silenced 5-HT neurons in the MR, and aimed to explore their roles in anxiety- and depressive-like behaviors...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29775928/tributyltin-impaired-reproductive-success-in-female-zebrafish-through-disrupting-oogenesis-reproductive-behaviors-and-serotonin-synthesis
#2
Wei-Yang Xiao, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Liu
Tributyltin (TBT), an organotin acting as aromatase (Cyp19a1) inhibitor, has been found to disrupt gametogenesis and reproductive behaviors in several fish species. However, few studies addressing the mechanisms underlying the impaired gametogenesis and reproduction have been reported. In this study, female adults of zebrafish (Danio rerio) were continuously exposed to two nominal concentrations of TBT (100 and 500 ng/L, actual concentrations: 90.8 ± 1.3 ng/L and 470.3 ± 2.7 ng/L, respectively) for 28 days...
May 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29738613/results-of-the-ahod0431-trial-of-response-adapted-therapy-and-a-salvage-strategy-for-limited-stage-classical-hodgkin-lymphoma-a-report-from-the-children-s-oncology-group
#3
Frank G Keller, Sharon M Castellino, Lu Chen, Qinglin Pei, Stephan D Voss, Kathleen M McCarten, Stacy L Senn, Allen B Buxton, Rizvan Bush, Louis S Constine, Cindy L Schwartz
BACKGROUND: The Children's Oncology Group AHOD0431 study evaluated a response-directed treatment paradigm in which minimal initial chemotherapy and low-dose radiation was received only by patients who did not achieve a complete remission, and a chemotherapy/low-dose radiation salvage regimen was received by those who had a protocol-defined, low-risk recurrence. METHODS: Patients younger than 21 years who had stage IA or IIA nonbulky disease were eligible. The treatment strategy was evaluated by determining the proportion that received minimal chemotherapy alone, the proportion that had a first or second remission without the receipt of high-dose chemotherapy/stem cell rescue or higher dose involved-field radiation therapy (>21 grays), and overall survival...
May 8, 2018: Cancer
https://www.readbyqxmd.com/read/29616304/tumor-metabolism-assessed-by-fdg-pet-ct-and-tumor-proliferation-assessed-by-genomic-grade-index-to-predict-response-to-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer
#4
David Groheux, L Biard, J Lehmann-Che, L Teixeira, F A Bouhidel, B Poirot, P Bertheau, P Merlet, M Espié, M Resche-Rigon, C Sotiriou, P de Cremoux
PURPOSE: Survival is increased when pathological complete response (pCR) is reached after neoadjuvant chemotherapy (NAC), especially in triple-negative breast cancer (TNBC) patients. Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) and the genomic grade index (GGI), each separately, showed good potential to predict pCR. Our study was designed to evaluate the predictive value for the therapeutic response of a combination of parameters based on FDG-PET, histoclinical features and molecular markers of proliferation...
April 4, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29534485/recombination-events-involving-the-atp9-gene-are-associated-with-male-sterility-of-cms-pet2-in-sunflower
#5
Antje Reddemann, Renate Horn
Cytoplasmic male sterility (CMS) systems represent ideal mutants to study the role of mitochondria in pollen development. In sunflower, CMS PET2 also has the potential to become an alternative CMS source for commercial sunflower hybrid breeding. CMS PET2 originates from an interspecific cross of H. petiolaris and H. annuus as CMS PET1, but results in a different CMS mechanism. Southern analyses revealed differences for atp6 , atp9 and cob between CMS PET2, CMS PET1 and the male-fertile line HA89. A second identical copy of atp6 was present on an additional CMS PET2-specific fragment...
March 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29519408/evaluation-of-third-treatment-week-as-temporal-window-for-assessing-responsiveness-on-repeated-fdg-pet-ct-scans-in-non-small-cell-lung-cancer-patients
#6
M Lazzeroni, J Uhrdin, S Carvalho, W van Elmpt, P Lambin, A Dasu, P Wersäll, I Toma-Dasu
PURPOSE: Early assessment of tumour response to treatment with repeated FDG-PET-CT imaging has potential for treatment adaptation but it is unclear what the optimal time window for this evaluation is. Previous studies indicate that changes in SUVmean and the effective radiosensitivity (αeff , accounting for uptake variations and accumulated dose until the second FDG-PET-CT scan) are predictive of 2-year overall survival (OS) when imaging is performed before radiotherapy and during the second week...
February 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29480158/utilization-of-a-hybrid-finite-element-based-registration-method-to-quantify-heterogeneous-tumor-response-for-adaptive-treatment-for-lung-cancer-patients
#7
Hoda Sharifi, Hong Zhang, Hassan Bagher-Ebadian, Wei Lu, Munther I Ajlouni, Jian-Yue Jin, Feng-Ming Spring Kong, Indrin J Chetty, Hualiang Zhong
Tumor response to radiation treatment (RT) can be evaluated from changes in metabolic activity between two positron emission tomography (PET) images. Activity changes at individual voxels in pre-treatment PET images (PET1), however, cannot be derived until their associated PET-CT (CT1) images are appropriately registered to during-treatment PET-CT (CT2) images. This study aimed to investigate the feasibility of using deformable image registration (DIR) techniques to quantify radiation-induced metabolic changes on PET images...
March 21, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29453444/positive-regulation-of-raphe-serotonin-neurons-by-serotonin-2b-receptors
#8
Arnauld Belmer, Emily Quentin, Silvina L Diaz, Bruno P Guiard, Sebastian P Fernandez, Stéphane Doly, Sophie M Banas, Pothitos M Pitychoutis, Imane Moutkine, Aude Muzerelle, Anna Tchenio, Anne Roumier, Manuel Mameli, Luc Maroteaux
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin reuptake inhibitor antidepressants. In this work, we tested the hypothesis that 5-HT2B receptors directly and positively regulate raphe serotonin neuron activity...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29417984/-18-f-fluorodeoxyglucose-pet-ct-and-prediction-of-histopathological-response-to-neoadjuvant-chemotherapy-for-adenocarcinoma-of-the-oesophagus-and-oesophagogastric-junction
#9
T Harustiak, M Zemanova, P Fencl, L Hornofova, A Pazdro, M Snajdauf, E Salkova, R Lischke, A Stolz
BACKGROUND: The aim of this prospective study was to assess whether [18 F]fluorodeoxyglucose PET can be used to predict histopathological response early in the course of neoadjuvant chemotherapy in patients with adenocarcinoma of the oesophagus and oesophagogastric junction. METHODS: Following the PET response criteria in solid tumours (PERCIST 1.0) as a standardized method for semiquantitative assessment of metabolic response, FDG-PET/CT was performed before (PET1) and after (PET2) initiation of the first cycle of chemotherapy...
March 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29391910/prognostic-value-of-pre-and-post-treatment-fdg-pet-ct-parameters-in-small-cell-lung-cancer-patients
#10
Hyoungwoo Kim, Ie Ryung Yoo, Sun Ha Boo, Hye Lim Park, Joo Hyun O, Sung Hoon Kim
Purpose: To evaluate the prognostic value of PET parameters obtained from pre- and post-treatment FDG PET/CT examinations in patients with SCLC. Methods: Fifty-nine patients with initially diagnosed SCLC from 2009 to 2014 were included and had chemotherapy and/or concurrent chemoradiotherapy. FDG PET/CT examinations were performed before (PET1) and after (PET2) treatment to evaluate treatment response. A region of interest was placed over the primary lesion and metastatic lymph nodes within the thoracic cavity...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28560574/eortc-pet-response-criteria-are-more-influenced-by-reconstruction-inconsistencies-than-percist-but-both-benefit-from-the-earl-harmonization-program
#11
Charline Lasnon, Elske Quak, Pierre-Yves Le Roux, Philippe Robin, Michael S Hofman, David Bourhis, Jason Callahan, David S Binns, Cédric Desmonts, Pierre-Yves Salaun, Rodney J Hicks, Nicolas Aide
BACKGROUND: This study evaluates the consistency of PET evaluation response criteria in solid tumours (PERCIST) and European Organisation for Research and Treatment of Cancer (EORTC) classification across different reconstruction algorithms and whether aligning standardized uptake values (SUVs) to the European Association of Nuclear Medicine acquisition (EANM)/EARL standards provides more consistent response classification. MATERIALS AND METHODS: Baseline (PET1) and response assessment (PET2) scans in 61 patients with non-small cell lung cancer were acquired in protocols compliant with the EANM guidelines and were reconstructed with point-spread function (PSF) or PSF + time-of-flight (TOF) reconstruction for optimal tumour detection and with a standardized ordered subset expectation maximization (OSEM) reconstruction known to fulfil EANM harmonizing standards...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28545563/additional-value-of-18-f-fdg-pet-ct-response-evaluation-in-axillary-nodes-during-neoadjuvant-therapy-for-triple-negative-and-her2-positive-breast-cancer
#12
Mette S van Ramshorst, Suzana C Teixeira, Bas B Koolen, Kenneth E Pengel, Kenneth G Gilhuijs, Jelle Wesseling, Sjoerd Rodenhuis, Renato A Valdés Olmos, Emiel J Rutgers, Wouter V Vogel, Gabe S Sonke, Marie-Jeanne T Vrancken Peeters
BACKGROUND: 18 F-FDG PET/CT can monitor metabolic activity in early breast cancer during neoadjuvant systemic therapy (NST), but it is unknown if the metabolic breast and axillary response differ. We evaluated the correlation between metabolic breast and axillary response at various time points during NST. Furthermore, we analysed if the combined metabolic response improves pathologic complete response (pCR) prediction compared to using the metabolic breast response alone. METHODS: 18 F-FDG PET/CT was performed at baseline (PET1), 2-3 weeks (PET2), and 6-8 weeks (PET3) of NST in patients with triple-negative (TN) and HER2-positive node-positive breast cancer...
May 25, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28324966/random-forests-to-predict-tumor-recurrence-following-cervical-cancer-therapy-using-pre-and-per-treatment-18-f-fdg-pet-parameters
#13
Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier
The ability to predict tumor recurrence after chemoradiotherapy of locally advanced cervical cancer is a crucial clinical issue to intensify the treatment of the most high-risk patients. The objective of this study was to investigate tumor metabolism characteristics extracted from pre- and per-treatment (18)F-FDG PET images to predict 3-year overall recurrence (OR). A total of 53 locally advanced cervical cancer patients underwent pre- and per-treatment (18)F-FDG PET (respectively PET1 and PET2). Tumor metabolism was characterized through several delineations using different thresholds, based on a percentage of the maximum uptake, and applied by region-growing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227014/random-forests-to-predict-tumor-recurrence-following-cervical-cancer-therapy-using-pre-and-per-treatment-18-f-fdg-pet-parameters
#14
Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier, Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier, Oscar Acosta, Julie Leseur, Juan-David Ospina, Geoffrey Roman-Jimenez, Henri Der Sarkissian, Renaud De Crevoisier, Anne Devillers, Eloise Grossiord, Lina Guzman
The ability to predict tumor recurrence after chemoradiotherapy of locally advanced cervical cancer is a crucial clinical issue to intensify the treatment of the most high-risk patients. The objective of this study was to investigate tumor metabolism characteristics extracted from pre- and per-treatment (18)F-FDG PET images to predict 3-year overall recurrence (OR). A total of 53 locally advanced cervical cancer patients underwent pre- and per-treatment (18)F-FDG PET (respectively PET1 and PET2). Tumor metabolism was characterized through several delineations using different thresholds, based on a percentage of the maximum uptake, and applied by region-growing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28193866/the-ets-5-transcription-factor-regulates-activity-states-in-caenorhabditis-elegans-by-controlling-satiety
#15
Vaida Juozaityte, David Pladevall-Morera, Agnieszka Podolska, Steffen Nørgaard, Brent Neumann, Roger Pocock
Animal behavior is shaped through interplay among genes, the environment, and previous experience. As in mammals, satiety signals induce quiescence in Caenorhabditis elegans Here we report that the C. elegans transcription factor ETS-5, an ortholog of mammalian FEV/Pet1, controls satiety-induced quiescence. Nutritional status has a major influence on C. elegans behavior. When foraging, food availability controls behavioral state switching between active (roaming) and sedentary (dwelling) states; however, when provided with high-quality food, C...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28073937/activity-of-tachykinin1-expressing-pet1-raphe-neurons-modulates-the-respiratory-chemoreflex
#16
Morgan L Hennessy, Andrea E Corcoran, Rachael D Brust, YoonJeung Chang, Eugene E Nattie, Susan M Dymecki
Homeostatic control of breathing, heart rate, and body temperature relies on circuits within the brainstem modulated by the neurotransmitter serotonin (5-HT). Mounting evidence points to specialized neuronal subtypes within the serotonergic neuronal system, borne out in functional studies, for the modulation of distinct facets of homeostasis. Such functional differences, read out at the organismal level, are likely subserved by differences among 5-HT neuron subtypes at the cellular and molecular levels, including differences in the capacity to coexpress other neurotransmitters such as glutamate, GABA, thyrotropin releasing hormone, and substance P encoded by the Tachykinin-1 ( Tac1 ) gene...
February 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28012347/enhanced-dendritic-morphogenesis-of-adult-hippocampal-newborn-neurons-in-central-5-ht-deficient-mice
#17
Ning-Ning Song, Qiong Zhang, Ying Huang, Ling Chen, Yu-Qiang Ding, Lei Zhang
Serotonin (5-HT) plays an important role in regulating adult hippocampal neurogenesis. Chronic administration of selective 5-HT reuptake inhibitors (SSRIs), which up-regulates extracellular 5-HT concentration, accelerates the maturation of adult-born hippocampal neurons. It is unknown, however, about effects of central 5-HT-deficiency on the dendritic morphogenesis of these newborn neurons. Here, we address this question using two central 5-HT-deficient mouse models, Tph2 conditional knockout mice (CKO) losing central 5-HT from embryonic stage, and Pet1-Cre;Rosa26-DTR (diphtheria toxin receptor) mice lacking central 5-HT neurons exclusively in adulthood...
March 2017: Stem Cell Research
https://www.readbyqxmd.com/read/27851959/identification-of-serotonergic-neuronal-modules-that-affect-aggressive-behavior
#18
Vera Niederkofler, Tedi E Asher, Benjamin W Okaty, Benjamin D Rood, Ankita Narayan, Lara S Hwa, Sheryl G Beck, Klaus A Miczek, Susan M Dymecki
Escalated aggression can have devastating societal consequences, yet underlying neurobiological mechanisms are poorly understood. Here, we show significantly increased inter-male mouse aggression when neurotransmission is constitutively blocked from either of two subsets of serotonergic, Pet1+ neurons: one identified by dopamine receptor D1(Drd1a)::cre-driven activity perinatally, and the other by Drd2::cre from pre-adolescence onward. Blocking neurotransmission from other Pet1+ neuron subsets of similar size and/or overlapping anatomical domains had no effect on aggression compared with controls, suggesting subtype-specific serotonergic neuron influences on aggression...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27789623/gata2-and-gata3-regulate-the-differentiation-of-serotonergic-and-glutamatergic-neuron-subtypes-of-the-dorsal-raphe
#19
Maarja Haugas, Laura Tikker, Kaia Achim, Marjo Salminen, Juha Partanen
Serotonergic and glutamatergic neurons of the dorsal raphe regulate many brain functions and are important for mental health. Their functional diversity is based on molecularly distinct subtypes; however, the development of this heterogeneity is poorly understood. We show that the ventral neuroepithelium of mouse anterior hindbrain is divided into specific subdomains giving rise to serotonergic neurons as well as other types of neurons and glia. The newly born serotonergic precursors are segregated into distinct subpopulations expressing vesicular glutamate transporter 3 (Vglut3) or serotonin transporter (Sert)...
December 1, 2016: Development
https://www.readbyqxmd.com/read/27587357/the-conundrum-of-udp-glc-entrance-into-the-yeast-er-lumen
#20
Luis M Bredeston, Cristina Marino-Buslje, Vanesa S Mattera, Lucila I Buzzi, Armando J Parodi, Cecilia D'Alessio
UDP-Glc entrance into the endoplasmic reticulum (ER) of eukaryotic cells is a key step in the quality control of glycoprotein folding, a mechanism requiring transfer of a Glc residue from the nucleotide sugar (NS) to glycoprotein folding intermediates by the UDP-Glc:glycoprotein glucosyltransferase (UGGT). According to a bioinformatics search there are only eight genes in the Schizosaccharomyces pombe genome belonging to the three Pfam families to which all known nucleotide-sugar transporters (NSTs) of the secretory pathway belong...
January 2017: Glycobiology
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