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Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier, Geoffrey Roman-Jimenez, Oscar Acosta, Julie Leseur, Anne Devillers, Henri Der Sarkissian, Lina Guzman, Eloi'se Grossiord, Juan-David Ospina, Renaud De Crevoisier, Oscar Acosta, Julie Leseur, Juan-David Ospina, Geoffrey Roman-Jimenez, Henri Der Sarkissian, Renaud De Crevoisier, Anne Devillers, Eloise Grossiord, Lina Guzman
The ability to predict tumor recurrence after chemoradiotherapy of locally advanced cervical cancer is a crucial clinical issue to intensify the treatment of the most high-risk patients. The objective of this study was to investigate tumor metabolism characteristics extracted from pre- and per-treatment (18)F-FDG PET images to predict 3-year overall recurrence (OR). A total of 53 locally advanced cervical cancer patients underwent pre- and per-treatment (18)F-FDG PET (respectively PET1 and PET2). Tumor metabolism was characterized through several delineations using different thresholds, based on a percentage of the maximum uptake, and applied by region-growing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Vaida Juozaityte, David Pladevall-Morera, Agnieszka Podolska, Steffen Nørgaard, Brent Neumann, Roger Pocock
Animal behavior is shaped through interplay among genes, the environment, and previous experience. As in mammals, satiety signals induce quiescence in Caenorhabditis elegans Here we report that the C. elegans transcription factor ETS-5, an ortholog of mammalian FEV/Pet1, controls satiety-induced quiescence. Nutritional status has a major influence on C. elegans behavior. When foraging, food availability controls behavioral state switching between active (roaming) and sedentary (dwelling) states; however, when provided with high-quality food, C...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
Morgan L Hennessy, Andrea Corcoran, Rachael D Brust, Eugene E Nattie, Susan Dymecki
: Homeostatic control of breathing, heart rate, and body temperature relies on circuits within the brainstem modulated by the neurotransmitter serotonin (5-HT). Mounting evidence points to specialized neuronal subtypes within the 5-HT system, which have borne out in functional studies, including the modulation of distinct facets of homeostatic control. These functional differences, read out at the organismal level, are likely subserved by differences among 5-HT neuron subtypes at the cellular and molecular levels, including differences in the capacity to co-express other neurotransmitters such as glutamate, GABA, thyrotropin releasing hormone, and substance P encoded by the Tachykinin-1 (Tac1) gene...
January 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Ning-Ning Song, Qiong Zhang, Ying Huang, Ling Chen, Yu-Qiang Ding, Lei Zhang
Serotonin (5-HT) plays an important role in regulating adult hippocampal neurogenesis. Chronic administration of selective 5-HT reuptake inhibitors (SSRIs), which up-regulates extracellular 5-HT concentration, accelerates the maturation of adult-born hippocampal neurons. It is unknown, however, about effects of central 5-HT-deficiency on the dendritic morphogenesis of these newborn neurons. Here, we address this question using two central 5-HT-deficient mouse models, Tph2 conditional knockout mice (CKO) losing central 5-HT from embryonic stage, and Pet1-Cre;Rosa26-DTR (diphtheria toxin receptor) mice lacking central 5-HT neurons exclusively in adulthood...
December 15, 2016: Stem Cell Research
Vera Niederkofler, Tedi E Asher, Benjamin W Okaty, Benjamin D Rood, Ankita Narayan, Lara S Hwa, Sheryl G Beck, Klaus A Miczek, Susan M Dymecki
Escalated aggression can have devastating societal consequences, yet underlying neurobiological mechanisms are poorly understood. Here, we show significantly increased inter-male mouse aggression when neurotransmission is constitutively blocked from either of two subsets of serotonergic, Pet1(+) neurons: one identified by dopamine receptor D1(Drd1a)::cre-driven activity perinatally, and the other by Drd2::cre from pre-adolescence onward. Blocking neurotransmission from other Pet1(+) neuron subsets of similar size and/or overlapping anatomical domains had no effect on aggression compared with controls, suggesting subtype-specific serotonergic neuron influences on aggression...
November 15, 2016: Cell Reports
Maarja Haugas, Laura Tikker, Kaia Achim, Marjo Salminen, Juha Partanen
Serotonergic and glutamatergic neurons of the dorsal raphe regulate many brain functions and are important for mental health. Their functional diversity is based on molecularly distinct subtypes; however, the development of this heterogeneity is poorly understood. We show that the ventral neuroepithelium of mouse anterior hindbrain is divided into specific subdomains giving rise to serotonergic neurons as well as other types of neurons and glia. The newly born serotonergic precursors are segregated into distinct subpopulations expressing vesicular glutamate transporter 3 (Vglut3) or serotonin transporter (Sert)...
December 1, 2016: Development
Luis M Bredeston, Cristina Marino-Buslje, Vanesa S Mattera, Lucila I Buzzi, Armando J Parodi, Cecilia D'Alessio
UDP-Glc entrance into the endoplasmic reticulum (ER) of eukaryotic cells is a key step in the quality control of glycoprotein folding, a mechanism requiring transfer of a Glc residue from the nucleotide sugar (NS) to glycoprotein folding intermediates by the UDP-Glc:glycoprotein glucosyltransferase (UGGT). According to a bioinformatics search there are only eight genes in the Schizosaccharomyces pombe genome belonging to the three Pfam families to which all known nucleotide-sugar transporters (NSTs) of the secretory pathway belong...
January 2017: Glycobiology
Julie Leseur, Geoffrey Roman-Jimenez, Anne Devillers, Juan D Ospina-Arango, Daniele Williaume, Joel Castelli, Pierre Terve, Vincent Lavoue, Etienne Garin, Florence Lejeune, Oscar Acosta, Renaud De Crevoisier
PURPOSE: To describe the evolution and to assess the predictive value of metabolic parameters with different SUV threshold segmentations calculated from two 18F-FDG-PET/CT, one prior to and the other one during concomitant chemoradiation therapy (CCRT), for locally-advanced cervical cancer (LACC). MATERIAL AND METHODS: 53 patients treated for LACC by CCRT underwent FDG-PET/CT before treatment (PET1) and another one at 40Gy (PET2). The PET analyzed parameters were: maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)...
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Christina Jentsch, Ralf Bergmann, Kerstin Brüchner, Birgit Mosch, Ala Yaromina, Mechthild Krause, Daniel Zips, Esther G C Troost, Steffen Löck, Jörg Kotzerke, Jörg Steinbach, Howard Thames, Michael Baumann, Bettina Beuthien-Baumann
OBJECTIVE: To investigate local tumour control after dose-escalation based on [(18)F]2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) obtained before and early during fractionated irradiation. MATERIALS AND METHODS: 85 mice bearing FaDu xenografts underwent FDG-PET twice: first immediately prior to the first 2-Gy fraction of irradiation (PET1_0) and second after 18°Gy (PET2_18). After these 9 fractions, animals were randomly allocated to: (1) continuation of 2-Gy fractions (cumulative dose of 60°Gy; n=31), (2) dose-escalation with 3-Gy fractions (cumulative EQD2-dose 86...
December 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Elske Quak, Pierre-Yves Le Roux, Charline Lasnon, Philippe Robin, Michael S Hofman, David Bourhis, Jason Callahan, David S Binns, Cédric Desmonts, Pierre Yves Salaun, Rodney J Hicks, Nicolas Aide
: Pre- and post-treatment positron emission tomography (PET) comparative scans should ideally be performed with identical acquisition and processing but this is often impractical. The degree to which differing protocols impact PET Evaluation Response Criteria In Solid Tumors (PERCIST) classification is unclear. This study evaluates the consistency of PERCIST classification across different reconstruction algorithms and whether a proprietary software tool can harmonize standardized uptake value (SUV) estimation sufficiently to provide consistent response classification...
June 9, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Hui Yuan, Daniel K H Tong, Varut Vardhanabhuti, Simon Y K Law, Keith W H Chiu, Pek-Lan Khong
OBJECTIVE: To investigate the role of fluorine-18-fluorodeoxyglucose PET/computed tomography for the prognostication and evaluation of neoadjuvant chemoradiotherapy response in locally advanced esophageal squamous cell carcinoma. METHODS: All consecutive biopsy-proven esophageal squamous cell carcinoma patients with PET/computed tomography at baseline (PET0) and 1 month after the completion of neoadjuvant chemoradiotherapy (PET1) between January 2008 and December 2013, followed by esophagectomy, were included...
September 2016: Nuclear Medicine Communications
Laura L Travaini, Maria G Zampino, Marzia Colandrea, Mahila E Ferrari, Laura Gilardi, Maria C Leonardi, Luigi Santoro, Roberto Orecchia, Chiara M Grana
OBJECTIVE: The aim of the present study is to evaluate the accuracy of Positron Emission Tomography/Computed Tomography (PET/CT) with Fluorodeoxyglucose ([18F]FDG) to predict treatment response in patients with locally advanced rectal cancer (LARC) during neoadjuvant chemoradiotherapy. PATIENTS AND METHODS: Forty-one LARC patients performed [18F]FDG-PET/CT at baseline (PET0). All patients received continuous capecitabine concomitant to radiotherapy on the pelvis, followed by intermittent capecitabine until two weeks before curative surgery...
2016: Ecancermedicalscience
Karlene T Barrett, Ryan T Dosumu-Johnson, J Andrew Daubenspeck, Rachael D Brust, Vasileios Kreouzis, Jun Chul Kim, Aihua Li, Susan M Dymecki, Eugene E Nattie
UNLABELLED: Sudden infant death syndrome (SIDS) cases often have abnormalities of the brainstem raphe serotonergic (5-HT) system. We hypothesize that raphe dysfunction contributes to a failure to autoresuscitate from multiple hypoxic events, leading to SIDS. We studied autoresuscitation in two transgenic mouse models in which exocytic neurotransmitter release was impaired via conditional expression of the light chain from tetanus toxin (tox) in raphe neurons expressing serotonergic bacterial artificial chromosome drivers Pet1 or Slc6a4...
April 6, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Assuero Giorgetti, Giovanni Pallabazzer, Andrea Ripoli, Biagio Solito, Dario Genovesi, Monica Lencioni, Maria Grazia Fabrini, Simone D'Imporzano, Laura Pieraccini, Paolo Marzullo, Stefano Santi
To investigate the prognostic value of tumor metabolism measurements on serial 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and computed tomography scans in patients with locally advanced esophageal cancer undergoing neoadjuvant chemoradiotherapy. Forty-five patients (63 ± 7 years, 6 female) treated with concomitant chemoradiotherapy before surgery were followed up for 24 ± 18 months (range 4-71). Positron emission tomography and computed tomography scans were obtained within 1 week before the start (PET1) and 1 month after the completion of the treatment (PET2)...
March 2016: Medicine (Baltimore)
Laetitia Padovani, Aurelie Baret, Joseph Ciccolini, David Taieb, Farman Bardia, Laetitia Teissonnier, Xavier Muracciole, Fabrice Barlesi, Dominique Barbolosi
OBJECTIVE: Positron emission tomography with (18)F fludeoxyglucose integrated with CT ((18)F-FDG PET/CT) is a recommended imaging procedure in the evaluation of non-small-cell lung cancers (NSCLCs). Radiochemotherapy (RCT) is a mainstay for treatment of locally advanced NSCLC, for which overall survival still remains poor. Early evaluation of treatment response may help in decision-making to complete radiotherapy (RT) or to switch to other treatment modalities. The present study aimed to evaluate the performance of new metabolic parameters based on a simplified kinetic analysis on a single time point (SKA-S)-derived mathematical method, as compared with standardized uptake value (SUV) measurement during RT...
June 2016: British Journal of Radiology
Ning-Ning Song, Yun-Fang Jia, Lei Zhang, Qiong Zhang, Ying Huang, Xiao-Zhen Liu, Ling Hu, Wei Lan, Ling Chen, Klaus-Peter Lesch, Xiaoyan Chen, Lin Xu, Yu-Qiang Ding
Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreER(T2) mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis...
February 3, 2016: Scientific Reports
Sebastian Pablo Fernandez, Bruno Cauli, Carolina Cabezas, Aude Muzerelle, Jean-Christophe Poncer, Patricia Gaspar
Serotonergic neurons of the raphe nuclei exhibit anatomical, neurochemical and elecrophysiological heterogeneity that likely underpins their specific role in multiple behaviors. However, the precise organization of serotonin (5-HT) neurons to orchestrate 5-HT release patterns throughout the brain is not well understood. We compared the electrophysiological and neurochemical properties of dorsal and median raphe 5-HT neurons projecting to the medial prefrontal cortex (mPFC), amygdala (BLA) and dorsal hippocampus (dHP), combining retrograde tract tracing with brain slice electrophysiology and single-cell RT-PCR in Pet1-EGFP mice...
November 2016: Brain Structure & Function
Jacob E Montgomery, Timothy D Wiggin, Luis M Rivera-Perez, Christina Lillesaar, Mark A Masino
Zebrafish intraspinal serotonergic neuron (ISN) morphology and distribution have been examined in detail at different ages; however, some aspects of the development of these cells remain unclear. Although antibodies to serotonin (5-HT) have detected ISNs in the ventral spinal cord of embryos, larvae, and adults, the only tryptophan hydroxylase (tph) transcript that has been described in the spinal cord is tph1a. Paradoxically, spinal tph1a is only expressed transiently in embryos, which brings the source of 5-HT in the ISNs of larvae and adults into question...
June 2016: Developmental Neurobiology
Yimin Li, Qin Lin, Zuoming Luo, Long Zhao, Luchao Zhu, Long Sun, Hua Wu
This study is to investigate the value of the metabolic parameters measured by sequential FDG PET/CT in predicting the overall survival of patients with esophageal squamous cell carcinoma (ESCC). A total of 160 patients who were newly diagnosed as ESCC patients and treated with chemoradiotherapy were included in this study. The FDG PET/CT was carried out prior to radiotherapy (PET1), when the cumulative dose of radiotherapy reached 50 Gy (PET2), at the end of radiotherapy (PET3) and 1 month after radiotherapy (PET4)...
2015: International Journal of Clinical and Experimental Medicine
Francesco Ceci, Paolo Castellucci, Tiziano Graziani, Riccardo Schiavina, Riccardo Renzi, Marco Borghesi, Piergiorgio Di Tullio, Eugenio Brunocilla, Andrea Ardizzoni, Stefano Fanti
PURPOSE: To investigate the role of (11)C-choline PET/CT for evaluating the response to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with docetaxel in comparison with PSA response. METHODS: Inclusion criteria were (a) proven mCRPC, (b) docetaxel as first line of chemotherapy (docetaxel 75 mg/m(2) + prednisone 5 mg), and (c) (11)C-choline PET/CT and PSA values assessed before and after docetaxel administration. A total of 61 patients were retrospectively enrolled (mean age 68...
January 2016: European Journal of Nuclear Medicine and Molecular Imaging
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