Read by QxMD icon Read


J J Zhao, Y L Zhang, S J Zhang, J Zhou, F K Yu, Y L Zu, H F Zhao, Z Li, Y P Song
Objective: To investigate the molecular-cytogenetic characterization and impact on tyrosine kinase inhibitors (TKIs) therapy in chronic phase of chronic myeloid leukemia (CML-CP) patients with variant Ph chromosome (vPh). Methods: The clinical data of 32 patients with vPh chromosomes were collected and compared with 703 patients with typical Ph chromosome in newly diagnosed CML-CP who were on first-line imatinib (IM) and with BCR-ABL transcript of P210. Results: There was no significant difference in demographic and hematological characteristics between vPh and classic Ph patients...
March 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Jiali Chen, Yan Li, Bing Yu, Daiwen Chen, Xiangbing Mao, Ping Zheng, Junqiu Luo, Jun He
Chlorogenic acid (CGA) is a natural phenolic acid, which is an important component of biologically active dietary phenols isolated from various species. Two experiments were conducted to investigate the effects of CGA on growth performance, antioxidant capacity, nutrient digestibility, diarrhea incidence, intestinal digestion and absorption function, and the expression levels of intestinal digestion and absorption-related genes in weaned pigs. In Exp. 1, 200 weaned pigs were randomly allotted to four dietary treatments and fed with a basal diet or a basal diet supplemented with 250, 500, or 1,000 mg/kg CGA, respectively, in a 14-d trial...
March 16, 2018: Journal of Animal Science
Daniele Dona, Maura Baraldi, Giulia Brigadoi, Rebecca Lundin, Giorgio Perilongo, Rana F Hamdy, Theoklis Zaoutis, Liviana Da Dalt, Carlo Giaquinto
BACKGROUND: Although Italian pediatric antimicrobial prescription rates are among the highest in Europe, little action has been taken to improve the appropriateness of antimicrobial prescriptions. The primary aim of this study was to assess changes in antibiotic prescription before and after acute otitis media (AOM) and group A streptococcus (GAS) pharyngitis Clinical Pathway (CP) implementation; secondary aims were to compare treatment failures and to assess change in the total antibiotics costs before and after CP implementation...
March 14, 2018: Pediatric Infectious Disease Journal
Igor L Fedushkin, Anton N Lukoyanov, Evgeny V Baranov
The reduction of 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene (dpp-Bian) with an excess of La metal in the presence of iodine (dpp-Bian/I2 = 2/1) in tetrahydrofuran (thf) or dimethoxyethane (dme) affords lanthanum(III) complexes of dpp-Bian dianion: deep blue [(dpp-Bian)2- LaI(thf)2 ]2 (1, 84%) was isolated by crystallization of the product from hexane, while deep green [(dpp-Bian)LaI(dme)2 ] (2, 93%) precipitated from the reaction mixture in the course of its synthesis. A treatment of complex 1 with 0...
March 21, 2018: Inorganic Chemistry
Ming Zheng, Fang-Yuan Chen, Jia-Nan Tian, Qing-Jiang Pan
To provide deep insight into cation-cation interactions (CCIs) involving hexavalent actinyl species that are major components in spent nuclear fuel and pose important implications for the effective removal of radiotoxic pollutants in the environment, a series of homo- and heterobimetallic actinide complexes supported by cyclopentadienyl (Cp) and polypyrrolic macrocycle (H4 L) ligands were systematically investigated using relativistic density functional theory. The metal sort in both parts of (THF)(H2 L)(OAnVI O) and (An')III Cp3 from U to Np to Pu, as well as the substituent bonding to Cp from electron-donating Me to H to electron-withdrawing Cl, SiH3 , and SiMe3 , was changed...
March 21, 2018: Inorganic Chemistry
Asiyeh Karimi, Forouzan Absalan, Layasadat Khorsandi, Armita Valizadeh, Esrafil Mansouri
Background: Hydrogen sulfide (H2S) has been shown to have a protective role in various kidney disorders. Objectives: This study investigated the molecular mechanism of NaHS (a H2S donor) in treating on the renal damage induced by cisplatin (CP). Materials and Methods: Thirty-two male rats were randomly divided into 4 groups: Normal control group (group A)' NaHS group (group B) which received 200 µg/kg/d (intraperitoneal injection; i.p.) for 15 days' CP group (group C) which rats were injected with CP (5 mg/kg, single dose, i...
July 2017: Journal of Nephropathology
César Calvo-Lobo, Francisco Unda-Solano, Daniel López-López, Irene Sanz-Corbalán, Carlos Romero-Morales, Patricia Palomo-López, Jesús Seco-Calvo, David Rodríguez-Sanz
Purpose: This study aim was to compare the effectiveness of the median nerve neural mobilization (MNNM) and cervical lateral glide (CLG) intervention versus oral ibuprofen (OI) in subjects who suffer cervicobrachial pain (CP). Methods: This investigation was a, multicenter, blinded, randomized controlled clinical trial (NCT02595294; NCT02593721). A number of 105 individuals diagnosed with CP were enrolled in the study and treated in 2 different medical facilities from July to November 2015. Participants were recruited and randomly assigned into 3 groups of 35 subjects...
2018: International Journal of Medical Sciences
Elke von Son-de Fernex, Ángel Alonso-Díaz Miguel, Braulio Valles-de la Mora, Pedro Mendoza-de Gives, Epigmenio Castillo-Gallegos, Alejandro Zamilpa, Manases González-Cortazar
The aims of this study were: 1) to assess the anthelmintic effect of Gliricidia sepium on the establishment of C. punctata third-stage larvae (L3 ) in calves, and 2) to isolate and to elucidate an anti-exsheathment phytochemical from the plant offered during the trial. Twelve ¾ Holstein × Zebu calves were divided in two experimental groups: control (T1) and treatment (T2) (n = 6). After adaptation, each calf was infected with an oral dose of 400 C. punctata L3 /Kg LW. Basal diet consisted of Digitaria decumbens hay (6...
March 15, 2018: Veterinary Parasitology
Carlo Pinna, Carla Giuditta Vecchiato, Carmen Bolduan, Monica Grandi, Claudio Stefanelli, Wilhelm Windisch, Giuliano Zaghini, Giacomo Biagi
BACKGROUND: Feeding dogs with diets rich in protein may favor putrefactive fermentations in the hindgut, negatively affecting the animal's intestinal environment. Conversely, prebiotics may improve the activity of health-promoting bacteria and prevent bacterial proteolysis in the colon. The aim of this study was to evaluate the effects of dietary supplementation with fructooligosaccharides (FOS) on fecal microbiota and apparent total tract digestibility (ATTD) in dogs fed kibbles differing in protein content...
March 20, 2018: BMC Veterinary Research
Meng Tian, Yu Long, Dan Xu, Shuoyun Wei, Zhengping Dong
Nowadays, chemical catalytic methods for the treatment of organic wastes are attracting more and more research attention. In the current research, novel catalysts with palladium nanoparticles (Pd NPs) supported on the hollow mesoporous silica nanotubes (h-mSiO2 ) were synthesized for the catalytic reduction of 4-nitrophenol (4-NP) and hydrodechlorination (HDC) of 4-chlorophenol (4-CP). The key point for the fabrication of the catalysts is that a certain thickness of the silica shell was wrapped on the multiwalled carbon nanotubes (MWNTs) or Pd/MWNTs through biphase stratification approach, and then the samples were calcined to remove the MWNTs...
March 14, 2018: Journal of Colloid and Interface Science
Marit Sørvoll, Aud Obstfelder, Britt Normann, Gunn Kristin Øberg
BACKGROUND: Physiotherapy from an early age is considered important for children with cerebral palsy (CP). In preschool, dedicated aides are responsible for the daily follow-up and training under the supervision of a physiotherapist (PT). Knowledge is sparse regarding what is created and achieved in clinical practice involving triads (i.e. the PT, aide, and child) with respect to the enhancement of practical skills in dedicated aides. The study purpose was to explore form and content in supervision...
March 20, 2018: Physiotherapy Theory and Practice
Jarred G Gillett, Glen A Lichtwark, Roslyn N Boyd, Lee A Barber
PURPOSE: To investigate the efficacy of a 12-week combined functional anaerobic and strength training program on neuromuscular properties and functional capacity in young adults with spastic-type CP. METHODS: 17 young adults (21±4 years, 9 males, GMFCS I=11, II=6) were randomized to 12 weeks, 3 sessions per week, of high intensity functional anaerobic and progressive resistance training of the lower limbs (n=8), or a waitlist control group (n=9). Pre- and post-training plantar flexor and tibialis anterior muscle volumes and composition, passive and active plantar flexor muscle properties, and functional capacity outcomes were assessed...
March 20, 2018: Medicine and Science in Sports and Exercise
A M Vaira, H S Lim, G Bauchan, C J Gulbronson, L Miozzi, N Vinals, A Natilla, J Hammond
The Lolium latent virus (LoLV) major coat protein sequence contains a typical chloroplast transit peptide (cTP) domain. In infected Nicotiana benthamiana leaf tissue, LoLV coat proteins can be detected at the chloroplast. In transient expression, several N-terminal deletions of the CP sequence, increasing in length, result in disruption of the domain functionality, markedly affecting intracellular localization. A yeast two-hybrid-based study using LoLV CP as bait identified several potentially interacting Arabidopsis host proteins, most of them with chloroplast-linked pathways...
March 20, 2018: Journal of General Virology
Lance B Irons, Heidi Flatin, Maya T Harrington, Turaj Vazifedan, John W Harrington
This article assesses parental confidence and current behavioral techniques used by mostly African American caregivers of young children in an urban Southeastern setting, including their use and attitudes toward corporal punishment (CP). Two hundred and fifty parental participants of children aged 18 months to 5 years completed a survey on factors affecting their behavioral management and views on CP. Statistical analysis included χ2 test and logistic regression with confidence interval significance determined at P <...
March 1, 2018: Clinical Pediatrics
Ege Riza Karagur, Cennet Ozay, Ramazan Mammadov, Hakan Akca
Scientists are increasingly focusing attention on natural products of plant origin for use as agents in cancer protection and treatment. Cyclamen L. tuber extracts contain saponin glycosides that have been shown to have anti-cancer and other biological activities. The epithelial-to-mesenchymal transition (EMT) is thought to enhance malignant tumour progress. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is an important inducer of EMT in different human tumours and has recently been shown to boost invasion by tumour cells...
March 19, 2018: Journal of Natural Medicines
Debasish Deb, Ankita Shrestha, Indu B Maiti, Nrisingha Dey
Development of disease-resistant plant varieties achieved by engineering anti-microbial transgenes under the control of strong promoters can suffice the inhibition of pathogen growth and simultaneously ensure enhanced crop production. For evaluating the prospect of such strong promoters, we comprehensively characterized the full-length transcript promoter of Cassava Vein Mosaic Virus (CsVMV; -565 to +166) and identified CsVMV8 (-215 to +166) as the highest expressing fragment in both transient and transgenic assays...
2018: Frontiers in Plant Science
Katrin Elisabeth Giel, Sarah Paganini, Irena Schank, Paul Enck, Stephan Zipfel, Florian Junne
Objective: Problems in emotion processing potentially contribute to the development and maintenance of chronic pain. Theories focusing on attentional processing have suggested that dysfunctional attention deployment toward emotional information, i.e., attentional biases for negative emotions, might entail one potential developmental and/or maintenance factor of chronic pain. Methods: We assessed self-reported alexithymia, attentional orienting to and maintenance on emotional stimuli using eye tracking in 17 patients with chronic pain disorder (CP) and two age- and sex-matched control groups, 17 healthy individuals (HC) and 17 individuals who were matched to CP according to depressive symptoms (DC)...
2018: Frontiers in Psychiatry
Amanda Marie Blackmore, Natasha Bear, Eve Blair, Katherine Langdon, Lisa Moshovis, Kellie Steer, Andrew C Wilson
OBJECTIVE: To determine the early predictors of respiratory hospital admissions in young people with cerebral palsy (CP). DESIGN: A 3-year prospective cohort study using linked data. PATIENTS: Children and young people with CP, aged 1 to 26 years. MAIN OUTCOME MEASURES: Self-reported and carer-reported respiratory symptoms were linked to respiratory hospital admissions (as defined by the International Statistical Classification of Diseases and Related Health Problems 10th Revision codes) during the following 3 years...
March 19, 2018: Archives of Disease in Childhood
Jin Qu, Xin Zhao, Peter X Ma, Baolin Guo
Injectable hydrogels with multistimuli responsiveness to electrical field and pH as a drug delivery system have been rarely reported. Herein, we developed a series of injectable conductive hydrogels as "smart" drug carrier with the properties of electro-responsiveness, pH-sensitivity, and inherent antibacterial activity. The hydrogels were prepared by mixing chitosan-graft-polyaniline (CP) copolymer and oxidized dextran (OD) as a cross-linker. The chemical structures, morphologies, electrochemical property, swelling ratio, conductivity, rheological property, in vitro and in vivo biodegradation, and gelation time of hydrogels were characterized...
March 16, 2018: Acta Biomaterialia
Jihui Li, Yunna Song, Zheng Ma, Ning Li, Shuai Niu, Yongshen Li
In this article, flake graphite, nitric acid, peroxyacetic acid and phosphoric acid are used to prepare graphene oxide phosphonic and phosphinic acids (GOPAs), and GOPAs and polyvinyl alcohol (PVA) are used to synthesize polyvinyl alcohol graphene oxide phosphonate and phosphinate (PVAGOPs) in the case of faint acidity and ultrasound irradiation, and PVAGOPs are used to fabricate PVAGOPs film, and the structure and morphology of GOPAs, PVAGOPs and PVAGOPs film are characterized, and the thermal stability and mechanical properties of PVAGOPs film are investigated...
May 2018: Ultrasonics Sonochemistry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"