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https://www.readbyqxmd.com/read/29145074/ratiometric-electrochemical-assay-for-sensitive-detecting-microrna-based-on-dual-amplification-mechanism-of-duplex-specific-nuclease-and-hybridization-chain-reaction
#1
Yan-Hong Yuan, Bao-Zhu Chi, Shao-Hua Wen, Ru-Ping Liang, Zhi-Mei Li, Jian-Ding Qiu
We propose a ratiometric electrochemical assay for detecting microRNA (miRNA) on the basis of dual-amplification mechanism by using distinguishable electrochemical signals from thionine (Thi) and ferrocene (Fc). The thiol-modified and ferrocene-labeled hairpin capture probes (CP) are first immobilized on an Au electrode via Au-S reaction. The target miRNA hybridizes with CP and unfolding the hairpin structure of CP to form miRNA-DNA duplexes. Then, kamchatka crab duplex specific nuclease (DSN) specifically cleaves the DNA in miRNA-DNA duplexes, leading to the release of miRNA and another cleaves cycle, meanwhile, numerous Fc leaves away from the electrode surface and leads to the signal-off of Fc...
November 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29144876/effects-of-at-home-bleaching-in-smokers-30-month-follow-up
#2
J L de Geus, E Fernández, S Kossatz, A D Loguercio, A Reis
OBJECTIVE: This clinical study evaluated the color longevity after 30 months of at-home bleaching with 10% carbamide peroxide (CP) in smokers and nonsmokers. METHODS: Sixty patients, 30 smokers and 30 nonsmokers, were subjected to bleaching with 10% CP (Whiteness Perfect-FGM) for three hours daily for three weeks. The color was measured at baseline and at one month and 30 months after the completion of dental bleaching using the shade guide Vita classical organized by value (ΔSGU) and the shade guide Vita Bleachedguide 3D-MASTER...
November 2017: Operative Dentistry
https://www.readbyqxmd.com/read/29144840/feasibility-of-using-the-general-movements-assessment-of-infants-in-the-united-states
#3
Eileen Ricci, Christa Einspieler, Alexa K Craig
AIMS: To pilot the practicality of administering the Prechtl General Movements Assessment of infants (GMA) in the Neonatal Intensive Care Unit (NICU) setting and at home to infants at risk for developing cerebral palsy (CP). Additional aims included assessing inter-rater reliability and comparing GMA predictions to AIMS motor assessment at 12 months. METHODS: 12 "at risk" infants were recruited by convenience sample. Video recordings were obtained in the NICU and provided by parents after discharge...
November 16, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/29143530/modulation-of-spatio-temporal-particle-patterning-in-evaporating-droplets-applications-to-diagnostics-and-materials-science
#4
Rajarshi Guha, Farzad Mohajerani, Ahana Mukhopadhyay, Matthew Collins, Ayusman Sen, Darrell Velegol
Spatio-temporal particle patterning in evaporating droplets lacks a common design framework. Here, we demonstrate autonomous control of particle distribution in evaporating droplets through the imposition of a salt-induced self-generated electric field as a generalized patterning strategy. Through modeling, a new dimensionless number, termed "capillary-phoresis number" (CP), arises which determines the relative contributions of electrokinetic and convective transport to pattern formation, enabling one to accurately predict the mode of particle assembly by controlling the spontaneous electric field and surface potentials...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29143316/psychometric-properties-of-parent-and-child-reported-sleep-assessment-tools-in-children-with-cerebral-palsy-a-systematic-review
#5
REVIEW
Manuel Bautista, Koa Whittingham, Priya Edwards, Roslyn N Boyd
AIM: To determine whether any parent and child report sleep measure tools have been validated in children aged 0-18 years with cerebral palsy (CP). METHOD: A systematic search of five databases was performed up to June 2017. Studies were included if a sleep measure tool was used to evaluate sleep in children 0-18 years with CP based on international classifications of sleep. Sleep measures were assessed for psychometric data in children with CP. RESULTS: Only one paper which used the Schlaffragebogen für Kinder mit Neurologischen und Anderen Komplexen Erkrankungen (SNAKE) questionnaire met the study criteria...
November 16, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29143023/self-assembled-2-catenane-in-trapezoidal-metallacycles-with-cp-ir-corners
#6
Naifang Liu, Sheng-Li Huang, Xiaogang Liu, He-Kuan Luo, T S Andy Hor
A series of trapezoidal metallacycles were synthesized by the selective combination of a rigid with a flexible arm. [2]Catenane 3 was obtained by self-assembly when the cavity size of the trapezoidal rings was optimised.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29142773/suprasellar-and-third-ventricular-cavernous-malformation-lessons-learned-in-differential-diagnosis-and-surgical-planning
#7
Kay O Kulason, Julia R Schneider, Ralph Rahme, Fanni Ratzon, Todd A Anderson, Deborah R Shatzkes, Christopher G Filippi, Peter D Costantino, David J Langer, John A Boockvar
Background: While craniopharyngiomas (CPs) are the most common cystic suprasellar lesions in adults, cavernous malformations (CMs) only exceptionally occur in this location and are seldom considered in the differential diagnosis of such lesions. However, unlike CPs, suprasellar CMs are not typically approached via an endoscopic endonasal approach. Case Description: We present a unique clinical case of suprasellar and third ventricular CM mimicking a CP, posing a major decision-making dilemma at the levels of both preoperative diagnosis and surgical planning...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29142471/dachaihu-decoction-ameliorates-pancreatic-fibrosis-by-inhibiting-macrophage-infiltration-in-chronic-pancreatitis
#8
Li-Fang Duan, Xiao-Fan Xu, Lin-Jia Zhu, Fang Liu, Xiao-Qin Zhang, Nan Wu, Jian-Wei Fan, Jia-Qi Xin, Hong Zhang
AIM: To explore the role of macrophages in chronic pancreatitis (CP) and the effect of Dachaihu decoction (DCHD) on pancreatic fibrosis in mice. METHODS: KunMing mice were randomly divided into a control group, CP group, and DCHD group. In the CP and DCHD groups, mice were intraperitoneally injected with 20% L-arginine (3 g/kg twice 1 d/wk for 6 wk). Mice in the DCHD group were administered DCHD intragastrically at a dose of 14 g/kg/d 1 wk after CP induction. At 2 wk, 4 wk and 6 wk post-modeling, the morphology of the pancreas was observed using hematoxylin and eosin, and Masson staining...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29142443/oral-health-and-erectile-dysfunction
#9
REVIEW
Vijendra P Singh, Sunil K Nettemu, Sowmya Nettem, Rajesh Hosadurga, Sangeeta U Nayak
Ample evidence strongly supports the fact that periodontal disease is a major risk factor for various systemic diseases namely cardio-vascular disease, diabetes mellitus, etc. Recently, investigators focussed on exploring the link between chronic periodontitis (CP) and erectile dysfunction (ED) by contributing to the endothelial dysfunction. Both the diseases share common risk factors. Various studies conducted in different parts of the world in recent years reported the evidence linking this relationship as well as improvement in ED with periodontal treatment...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29142402/chromosomal-fragmentation-a-possible-marker-for-the-selection-of-high-gymnemic-acid-yielding-accessions-of-gymnema-sylvestre-r-br
#10
Ashutosh Kumar Verma, Sunita Singh Dhawan
Background: Gymnema sylvestre R. Br. a member of family Asclepiadaceae as mentioned in Indian Pharmacopoeia popular among the researchers because of stimulatory effect of its phytoconstituent on pancreatic cells and potential to treat Type I and II type of diabetes. Objectives: Development of cost-effective marker system for the selection of high gymnemic acid yielding accessions of G. sylvestre. Materials and Methods: Presoaked seeds of Brassica campestris treated with different dilutions of gymnemagenin and 10% leaf extract of twenty different accessions of G...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142154/the-choroid-plexus-of-the-lateral-ventricle-as-the-origin-of-csf-pulsation-is-questionable
#11
Ken Takizawa, Mitsunori Matsumae, Naokazu Hayashi, Akihiro Hirayama, Fumiya Sano, Satoshi Yatsushiro, Kagayaki Kuroda
The advent of magnetic resonance imaging (MRI) enables noninvasive measurement of cerebrospinal fluid (CSF) motion, and new information about CSF motion has now been acquired. The driving force of the CSF has long been thought to be choroid plexus (CP) pulsation, but to investigate whether this phenomenon actually occurs, CSF motion was observed in the ventricular system and subarachnoid space using MRI. Eleven healthy volunteers, ranging in age from 23 to 58 years, participated in this study. The MRI sequences used were four-dimensional phase-contrast (4D-PC) and time-spatial labeling inversion pulse (t-SLIP)...
November 16, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29141142/closing-the-loop-on-transition-metal-mediated-nitrogen-fixation-chemoselective-production-of-hn-sime3-2-from-n2-me3sicl-and-x-oh-x-r-r3si-or-silica-gel
#12
Leila M Duman, Lawrence R Sita
Chemical reduction of the Mo(IV) dichloride, Cp*[N(Et)C(Ph)N(Et)]MoCl2 (Cp* = η(5)-C5Me5) (1), in the presence of N2 has previously provided the dinuclear [Mo(II), Mo(II)] end-on-bridged μ-N2 complex, {Cp*[N(Et)C(Ph)N(Et)]Mo]}2(μ-η(1):η(1)-N2) (2), which, when heated in solution with Me3SiCl, provides the Mo(IV) terminal imido complex, Cp*[N(Et)C(Ph)N(Et)]Mo(NSiMe3) (3). Treatment of 3 with a 1 : 2 mixture of Me3SiOH and Me3SiCl, respectively, resulted in rapid and quantitative regeneration of 1 along with formation of one equivalent each of HN(SiMe3)2 and O(SiMe3)2...
November 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29141010/multiple-effects-of-toxins-isolated-from-crotalus-durissus-terrificus-on-the-hepatitis-c-virus-life-cycle
#13
Jacqueline Farinha Shimizu, Carina Machado Pereira, Cintia Bittar, Mariana Nogueira Batista, Guilherme Rodrigues Fernandes Campos, Suely da Silva, Adélia Cristina Oliveira Cintra, Carsten Zothner, Mark Harris, Suely Vilela Sampaio, Victor Hugo Aquino, Paula Rahal, Ana Carolina Gomes Jardim
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described. Therefore, studies for developing more efficient antivirals against HCV are needed. Compounds isolated from animal venoms have shown antiviral activity against some viruses such as Dengue virus, Yellow fever virus and Measles virus. In this study, we evaluated the effect of the complex crotoxin (CX) and its subunits crotapotin (CP) and phospholipase A2 (PLA2-CB) isolated from the venom of Crotalus durissus terrificus on HCV life cycle...
2017: PloS One
https://www.readbyqxmd.com/read/29140480/the-intrinsically-disordered-n-terminal-arm-of-the-brome-mosaic-virus-coat-protein-specifically-recognizes-the-rna-motif-that-directs-the-initiation-of-viral-rna-replication
#14
Alexander Jacobs, Haley Hoover, Edward Smith, David E Clemmer, Chul-Hyun Kim, C Cheng Kao
In the brome mosaic virus (BMV) virion, the coat protein (CP) selectively contacts the RNA motifs that regulate translation and RNA replication (Hoover et al., 2016. J. Virol. 90, 7748). We hypothesize that the unstructured N-terminal arm (NTA) of the BMV CP can specifically recognize RNA motifs. Using ion mobility spectrometry-mass spectrometry, we demonstrate that peptides containing the NTA of the CP were found to preferentially bind to an RNA hairpin motif that directs the initiation of BMV RNA synthesis...
November 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29140087/binuclear-cyclopentadienylmetal-methylene-sulfur-dioxide-complexes-of-rhodium-and-iridium-related-to-a-photochromic-metal-dithionite-complex
#15
Dongsheng Rong, Shida Gong, Chaoyang Wang, Qiong Luo, Qian-Shu Li, Yaoming Xie, R Bruce King, Henry F Schaefer
The photochromic dithionite complex Cp*2Rh2(μ-CH2)2(μ-O2SSO2) (Cp* = η(5)-Me5C5) is of interest because it undergoes an unusual fully reversible unimolecular photochemical rearrangement to the isodithionite complex Cp*2Rh2(μ-CH2)2(μ-O2SOSO). In order to obtain more insight into these systems, a comprehensive density functional theory study has been carried out on isomeric Cp2M2(CH2)2(SO2)2 (M = Rh, Ir) derivatives. The experimentally observed rhodium complexes with coupled sulfur dioxide (SO2) units to give dithionite or isodithionite ligands are surprisingly high-energy kinetic isomers in our analysis, reflecting the need for dithionite rather than SO2 for their synthesis...
November 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29139589/severe-fasting-hypoglycemia-in-a-child-after-total-pancreatectomy-with-islet-autotransplantation
#16
Jacob M Redel, Jaimie D Nathan, Maisam Abu-El-Haija, Tom K Lin, Joseph J Palermo, Deborah A Elder
TPIAT is an increasingly utilized treatment option for select children with CP. Post-TPIAT fasting hypoglycemia, unrelated to exogenous insulin, is a complication recently reported in adults. This phenomenon has not been described in children. We review a case of severe fasting hypoglycemia in an adolescent female occurring 10 months post-TPIAT. A 12-year-old girl underwent TPIAT for CP. Ten months postoperatively she developed recurrent hypoglycemia on a total daily insulin dose of 0.03 units/kg. Consequently, insulin therapy was discontinued...
November 15, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29139503/formation-of-a-spiro-compound-via-coupling-of-a-cyclopentadienyl-ligand-with-a-diene-moiety-of-titanacyclopentadiene
#17
Masayoshi Bando, Yuki Mizukami, Kiyohiko Nakajima, Zhiyi Song, Tamotsu Takahashi
The treatment of titanacyclopentadienes with bismuth(iii) chloride gave spiro compounds in moderate yields. Two carbon atoms of the diene moiety of the titanacyclopentadiene were connected to one carbon atom of the Cp ligand. This is in sharp contrast to the formation of dihydroindene derivatives, where two carbon-carbon bonds were formed between the diene moiety and the adjacent two carbon atoms of the Cp ligand.
November 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29138221/immature-cml-cells-implement-a-bmp-autocrine-loop-to-escape-tki-treatment
#18
Elodie Grockowiak, Bastien Laperrousaz, Sandrine Jeanpierre, Thibault Voeltzel, Boris Guyot, Stéphanie Gobert, Franck E Nicolini, Véronique Maguer-Satta
The BCR-ABL specific Tyrosine Kinase Inhibitors (TKI) changed the outcome of Chronic Myeloid Leukemia (CML), turning a life-threatening disease into a chronic illness. However, TKI are not yet curative, since most patients retain leukemic stem cells (LSC) and their progenitors in bone marrow and relapse following treatment cessation. At diagnosis, deregulations of the Bone Morphogenetic Proteins (BMP) pathway are involved in LSC and progenitors expansion. Here, we report that BMP pathway alterations persist in TKI-resistant patients...
November 14, 2017: Blood
https://www.readbyqxmd.com/read/29138072/preoperative-assessment-of-craniopharyngioma-adherence-mri-findings-correlated-with-the-severity-of-tumor-attachment-to-the-hypothalamus
#19
Ruth Prieto, José M Pascual, Maria Rosdolsky, Laura Barrios
BACKGROUND: Craniopharyngioma (CP) adherence represents a heterogeneous pathological feature that critically influences the potentially safe and radical resection. OBJECTIVE: To define the MRI predictors of CP adherence severity. METHODS: This study retrospectively investigated a cohort of 200 surgically treated CPs with their corresponding preoperative conventional MRI scans. MRI findings related to the distortions of anatomical structures along the sella turcica-third ventricle axis caused by CPs, in addition to the tumor's shape and calcifications were analyzed and correlated with the definitive type of CP adherence observed during the surgical procedures...
November 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29137811/improving-the-safety-of-metal-based-drugs-by-tuning-their-metabolism-with-chemoprotective-agents
#20
Jürgen Gailer
Metal-based drugs remain a tiny minority of all drugs that are on the market. The success story of the quintessential metal-based drug cisplatin (CP), which is intravenously administered to 70% of all cancer patients, however, demonstrates the inherent potential of metal-based drugs. A distinct disadvantage of CP is the dose-limiting severe toxic-side effects that it exerts in patients. To better understand the biomolecular basis for its toxicity, we employed a metallomics method to observe all platinum metabolites that are formed in blood plasma...
November 8, 2017: Journal of Inorganic Biochemistry
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