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https://www.readbyqxmd.com/read/28931142/malaria-prevention-strategies-and-recommendations-from-chemoprophylaxis-to-stand-by-emergency-treatment-a-10-year-prospective-study-in-a-swiss-travel-clinic
#1
Rim Boubaker, Annie Hérard Fossati, Pierrette Meige, Catherine Mialet, Chantal Ngarambe Buffat, Jacynthe Rochat, Manisinh Souvannaraj-Blanchant, Mediatrice Uwanyiligira, Francine Widmer, Sylvie Payot, Laurence Rochat, Serge de Vallière, Valérie D'Acremont, Blaise Genton
Background: There are several possible malaria prevention strategies for travellers. In Switzerland, chemoprophylaxis (CP) is recommended for persons visiting areas highly endemic for malaria and stand-by emergency treatment (SBET) for areas with moderate to low risk. Objective: To describe the type of malaria prevention prescribed to travel clinic attendees with a specific focus on changes over time following adaptation of recommendations. Methods: All pre-travel first consultation data recorded between November 2002 and December 2012 were included...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28930866/p2x7r-blockade-prevents-nlrp3-inflammasome-activation-and-pancreatic-fibrosis-in-a-mouse-model-of-chronic-pancreatitis
#2
Gui-Xian Zhang, Man-Xue Wang, Wei Nie, Da-Wei Liu, Yi Zhang, Hong-Bin Liu
OBJECTIVES: The aim of this study was to investigate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome activation in the process of pancreatic fibrosis in a mouse model of chronic pancreatitis (CP). METHODS: Chronic pancreatitis was induced by repeated intraperitoneal injections of 50 μg/kg cerulein for 6 weeks in mice. P2X7R antagonist oxidized ATP (OxATP) or brilliant blue G (BBG) was administered after the last cerulein injection for 2 weeks...
September 19, 2017: Pancreas
https://www.readbyqxmd.com/read/28929770/pyridyl-directed-cp-rh-iii-catalyzed-b-3-h-acyloxylation-of-o-carborane
#3
Chun-Xiao Li, Hao-Yun Zhang, Tsz-Yung Wong, Hou-Ji Cao, Hong Yan, Chang-Sheng Lu
An efficient pyridyl-directed Rh(III)-catalyzed o-carborane B(3)-H acyloxylation is reported. The B(3)-H bond is the most electron-deficient vertex on o-carborane whose functionalization is challenging. The combination of Cu(OH)2 and diverse carboxylic acids provides low cost and abundant acyloxyl sources which could lead to moderate to excellent yields.
September 20, 2017: Organic Letters
https://www.readbyqxmd.com/read/28929597/olefin-supported-rhenium-iii-terminal-oxo-complexes-generated-by-nucleophilic-addition-to-a-cyclopentadienyl-ligand
#4
Trevor Lohrey, Robert Bergman, John Arnold
The reactivity of the oxo Re(V) β-diketiminate, OReCl2(BDI), with various cyclopentadienide (Cp) sources has been investigated. As a result, we have developed a route to a new class of terminal oxo complexes of Re(III) supported by olefin moieties of substituted cyclopentadienes. The success of this pathway is due to the electrophilic nature of the Cp ligand in the cation, [ORe(η5-Cp)(BDI)]+ (3+), which allows for nucleophilic attack by a variety of reagents under mild conditions. In contrast, tBuNC was found to attack at the oxo moiety to produce isocyanate by oxygen atom transfer...
September 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28929518/reliability-and-validity-of-the-korean-language-version-of-the-communication-function-classification-system-in-children-with-cerebral-palsy
#5
J Y Choi, E H Hwang, D Rha, E S Park
PURPOSE: The Communication Function Classification System (CFCS) and Viking Speech Scale (VSS) are useful systems for describing the broad communication function and speech intelligibility, respectively, of children with cerebral palsy (CP). The aims of this study were to determine the reliability and validity of the Korean version of the CFCS and also to investigate the association between the CFCS and the VSS and other functional classifications for children with CP. MATERIALS AND METHODS: Participants were 50 children with CP (33 males, 17 females; mean age 7...
September 20, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28928994/foxe1-mutation-screening-in-a-case-with-cleft-lip-hypothyroidism-and-thyroid-carcinoma-a-new-syndrome
#6
Hugo Mendieta-Zerón, Angélica Jiménez-Rosales, Carlos Jhovani Pérez-Amado, Silvia Jiménez-Morales
A 26-year-old woman is referred to the Internal Medicine consultation due to increases in laboratory studies associated with Papillary Thyroid Carcinoma (PTC) that was confirmed by histopathological studies. Her clinical history revealed that, at 3 months of age, she was successfully treated with surgery for cleft lip (CL) and at the age of 24 years was diagnosed with hypothyroidism. Single nucleotide polymorphisms (SNPs) in FOXE1 and its promoter regions have been associated with various etiologies related to the thyroid, including orofacial clefting, specially cleft palate (CP) and CL, hypothyroidism (HT), and thyroid cancer...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/28928544/role-of-anesthesiologist-in-the-management-of-a-child-with-cerebral-palsy
#7
REVIEW
Safiya Imtiaz Shaikh, Ganapati Hegade
Cerebral palsy (CP) refers to a spectrum of nonprogressive neurological disorders with disturbances in posture and movement, resulting from perinatal intrauterine insult to developing infant brain. Many conditions associated with CP require surgery. Such cases pose important gastrointestinal, respiratory, and other perioperative considerations. Anesthetic management in these cases is delicate. Intraoperative complications including hypovolemia, hypothermia, muscle spasms, seizures, and delayed recovery might complicate the anesthetic management...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28928426/cyanobacterial-sfp-type-phosphopantetheinyl-transferases-functionalize-carrier-proteins-of-diverse-biosynthetic-pathways
#8
Guang Yang, Yi Zhang, Nicholas K Lee, Monica A Cozad, Sara E Kearney, Hendrik Luesch, Yousong Ding
Cyanobacteria produce structurally and functionally diverse polyketides, nonribosomal peptides and their hybrids. Sfp-type phosphopantetheinyl transferases (PPTases) are essential to the production of these compounds via functionalizing carrier proteins (CPs) of biosynthetic megaenzymes. However, cyanobacterial Sfp-type PPTases remain poorly characterized, posing a significant barrier to the exploitation of cyanobacteria for biotechnological and biomedical applications. Herein, we describe the detailed characterization of multiple cyanobacterial Sfp-type PPTases that were rationally selected...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928195/reach-study-protocol-of-a-randomised-trial-of-rehabilitation-very-early-in-congenital-hemiplegia
#9
Roslyn N Boyd, Jenny Ziviani, Leanne Sakzewski, Iona Novak, Nadia Badawi, Kerstin Pannek, Catherine Elliott, Susan Greaves, Andrea Guzzetta, Koa Whittingham, Jane Valentine, Cathy Morgan, Margaret Wallen, Ann-Christin Eliasson, Lisa Findlay, Robert Ware, Simona Fiori, Stephen Rose
OBJECTIVES: Congenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study compares the efficacy of infant-friendly modified constraint-induced movement therapy (Baby mCIMT) to infant friendly bimanual therapy (Baby BIM) on upper limb, cognitive and neuroplasticity outcomes in a multisite randomised comparison trial...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28927596/on-chemistry-of-%C3%AE-chitin
#10
Murat Kaya, Muhammad Mujtaba, Hermann Ehrlich, Asier M Salaberria, Talat Baran, Chris T Amemiya, Roberta Galli, Lalehan Akyuz, Idris Sargin, Jalel Labidi
The biological material, chitin, is present in nature in three allomorphic forms: α, β and γ. Whereas most studies have dealt with α- and β-chitin, only few investigations have focused on γ-chitin, whose structural and physicochemical properties have not been well delineated. In this study, chitin obtained for the first time from the cocoon of the moth (Orgyia dubia) was subjected to extensive physicochemical analyses and examined, in parallel, with α-chitin from exoskeleton of a freshwater crab and β-chitin from cuttlebone of the common cuttlefish...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28927475/impact-of-discontinuing-contact-precautions-for-mrsa-and-esble-in-an-intensive-care-unit-a-prospective-noninferiority-before-and-after-study
#11
Laurie Renaudin, Mathieu Llorens, Christophe Goetz, Sébastien Gette, Vincente Citro, Sylvia Poulain, Marie-Laure Vanson, Jocelyne Sellies
OBJECTIVE To compare incidence densities of methicillin-resistant Staphylococcus aureus (MRSA) or extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLE) acquisition in the intensive care unit (ICU) before and after discontinuation of contact precautions (CP) and application of standard precautions (SP). DESIGN Prospective noninferiority before-and-after study comparing 2 periods: January 1, 2012, to January 31, 2014 (the CP period) and February 1, 2014, to February 29, 2016 (the SP period). SETTING A 16-bed polyvalent ICU in France with only single-bed rooms with dedicated equipment and reusable medical devices...
September 20, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28927375/effects-of-lubrication-on-air-sealing-performance-of-a-pediatric-cuffed-tracheal-tube
#12
Hiroko Nishioka, Yutaka Usuda, Go Hirabayashi, Koichi Maruyama, Tomio Andoh
BACKGROUND: Lubrication of cuffed tracheal tubes (CTTs) reduces liquid leakage. However, it is not clear how cuff lubrication influences air leakage. We aimed to test the hypothesis that pretreatment with K-Y jelly, a water-soluble lubricant, would improve the air-sealing performance of pediatric CTTs in a model study. METHODS: We placed Parker Flex-Tip™ CTT with 4.0- and 5.0-mm internal diameter (ID) into a tracheal model with 9- and 12-mm ID. The tracheal model was connected to a test lung ventilated in pressure control mode...
September 19, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28927310/psychometric-evaluation-of-the-scandinavian-version-of-the-caregiver-priorities-and-child-health-index-of-life-with-disabilities
#13
Katina Pettersson, Kari Marte Bjerke, Reidun Jahnsen, John Öhrvik, Elisabet Rodby-Bousquet
PURPOSE: To examine test-retest reliability and construct validity of the Scandinavian version of the caregiver priorities and child health index of life with disabilities (CPCHILD) questionnaire for children with cerebral palsy (CP). METHODS: Families were recruited in Sweden and Norway and stratified according to the gross motor function classification system levels I-V for children born 2000-2011, mean age 7.9 (SD 3.2). Construct validity based on the first questionnaire (n = 106) was evaluated for known groups, using linear regression analysis...
September 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28926691/cobalt-porphyrin-thiazyl-radical-coordination-polymers-towards-metal-organic-electronics
#14
Delia A Haynes, Laura J van Laeren, Orde Q Munro
Herein we delineate an unusual one-dimensional coordination polymer (CP), 3, prepared from S = ½ Co(TPP), 1, (TPP = 5,10,15,20-tetraphenylporphyrin dianion) and S = ½ 4-(4'-pyridyl)-1,2,3,5-dithiadiazolyl (py-DTDA) radical, 2. The atypically long S-S distance for CP 3 (2.12 Å) reflects fractional electron transfer from the formally Co(II) ion into the antibonding π-SOMO of the metal-bound py-DTDA bridging ligand. The bonding in solid CP 3 involves non-integer redox states in a resonance hybrid repeat unit best formulated as [Co(TPP)](0...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28926645/alterations-in-regional-homogeneity-of-resting-state-cerebral-activity-in-patients-with-chronic-prostatitis-chronic-pelvic-pain-syndrome
#15
Yusong Lin, Yan Bai, Peng Liu, Xuejuan Yang, Wei Qin, Jianqin Gu, Degang Ding, Jie Tian, Meiyun Wang
The purpose of this study was to explore the neural mechanism in Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) using resting-state functional magnetic resonance imaging. The functional magnetic resonance imaging was performed on 31 male CP/CPPS-patients and 31 age and education matched male healthy controls on a 3-T magnetic resonance imaging unit. A two-sample t-test was adopted to reveal the regional homogeneity between the patients and healthy controls. The mean regional homogeneity values in the alerted brain regions of patients were correlated with the clinical measurements by using Pearson's correlation analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28926521/blockade-of-hla-antibody-triggered-classical-complement-activation-in-sera-from-subjects-dosed-with-the-anti-c1s-monoclonal-antibody-tnt009-results-from-a-randomized-first-in-human-phase-1-trial
#16
Jakob Mühlbacher, Bernd Jilma, Markus Wahrmann, Johann Bartko, Farsad Eskandary, Christian Schörgenhofer, Michael Schwameis, Graham C Parry, James C Gilbert, Sandip Panicker, Georg A Böhmig
BACKGROUND: Complement may play a key role in antibody-mediated rejection. A promising therapeutic approach may be classical pathway (CP) inhibition at the level of early component C1. METHODS: In this first-in-human, double-blind, randomized placebo-controlled phase 1 trial, we evaluated the safety and complement inhibitory effect of TNT009, a humanized monoclonal anti-C1s antibody. Sixty-four adult healthy volunteers received either single (n = 48; 7 consecutive cohorts, 0...
October 2017: Transplantation
https://www.readbyqxmd.com/read/28925893/big-data-analyses-for-continuous-evaluation-of-pharmacotherapy-a-proof-of-principle-with-doxapram-in-preterm-infants
#17
Robert Flint, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit Cp Koch, Ronald de Groot, Dick Tibboel, Catherijne Aj Knibbe, Irwin Km Reiss, Sinno Hp Simons
BACKGROUND: Drug effect evaluation is often based on subjective interpretation of a selection of patient data. Continuous analyses of high frequency patient monitor data are a valuable source to measure drug effects. However, these have not yet been fully explored in clinical care. We aim to evaluate the usefulness and applicability of high frequency physiological data for analyses of pharmacotherapy. METHODS: As a proof of principle, the effects of doxapram, a respiratory stimulant, on the oxygenation in preterm infants were studied...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925468/comparison-of-carboplatin-and-paclitaxel-with-or-without-bevacizumab-in-chemotherapeutic-regimens-for-unresectable-stage-iii-non-small-cell-lung-cancer
#18
T Ding, Z-T Li, X Zhang, Y-T Shi
OBJECTIVE: Our study aimed to compare the chemoradiotherapeutic regimens of carboplatin and paclitaxel with or without bevacizumab for stage III non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: From July 2010 to December 2016, 102 patients with inoperable stage III NSCLC were finally included and divided randomly into two groups. Patients in the CP group received the treatment of carboplatin (area under the curve of 6) on day 1 and paclitaxel (80 mg/m2) on days 1, 8, and 15...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28923743/heteroatom-rich-porous-organic-polymers-constructed-by-benzoxazine-linkage-with-high-carbon-dioxide-adsorption-affinity
#19
Shuju Xu, Jiang He, Shangbin Jin, Bien Tan
We report the synthesis and characterization of a new type of porous organic polymers linked by benzoxazine. The polymers were readily synthesized by condensation reaction of diamines, triphenol and paraformaldehyde. The formation of the linkage and porous structures were studied by infrared spectroscopy, solid-state (13)C-CP MAS NMR and nitrogen sorption measurements. The porosity study revealed the resultant polymers are porous materials with surface area as high as 231m(2)g(-1). Benzoxazine backbone endows the polymers with abundant heteroatoms (N and O), which makes these polymers promising candidates for carbon dioxide adsorption and storage...
September 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28923714/full-spectroscopic-characterization-of-two-crystal-pseudopolymorphic-forms-of-the-antiandrogen-cortexolone-17%C3%AE-propionate-for-topic-application
#20
Patrizia Ferraboschi, Maria Chiara Sala, Riccardo Stradi, Laura Ragonesi, Clarissa Gagliardi, Paolo Lanzarotti, Enzio M Ragg, Matteo Mori, Fiorella Meneghetti
Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occurr, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior. These latter pseudopolymorphic forms have also been fully characterized by spectroscopic methods.
September 15, 2017: Steroids
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