Yuan Su, Si Li, Xin Li, Jing-Ying Zhou, Vraj P Chauhan, Meng Li, Ya-Hui Su, Chun-Mei Liu, Yi-Fei Ren, Wu Yin, Jeffrey D Rimer, Ting Cai
Kidney stones are a pervasive disease with notoriously high recurrence rates that require more effective treatment strategies. Herein, tartronic acid is introduced as an efficient inhibitor of calcium oxalate monohydrate (COM) crystallization, which is the most prevalent constituent of human kidney stones. A combination of in situ experimental techniques and simulations are employed to compare the inhibitory effects of tartronic acid with those of its molecular analogs. Tartronic acid exhibits an affinity for binding to rapidly growing apical surfaces of COM crystals, thus setting it apart from other inhibitors such as citric acid, the current preventative treatment for kidney stones...
April 22, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)