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https://www.readbyqxmd.com/read/29353139/effects-of-lighting-illuminance-levels-on-stair-negotiation-performance-in-individuals-with-visual-impairment
#1
Aliah F Shaheen, Alexandros Sourlas, Khim Horton, Christopher McLean, David Ewins, David Gould, Salim Ghoussayni
BACKGROUND: Stair-related falls of older people cause a substantial financial and social burden. Deterioration of the visual system amongst other factors put older people at a high risk of falling. Improved lighting is often recommended. The aim of this study was to investigate the effect of lighting illuminance on stair negotiation performance in older individuals with visual impairment. METHODS: Eleven participants aged 60 or over with a vision of 6/18 or worse ascended and descended a staircase under: 50 lx, 100 lx, 200 lx, 300 lx and distributed 200 lx lighting...
January 16, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29352622/anaesthesia-for-caesarean-section-in-a-patient-with-parkinson-s-disease
#2
V D Ward
Parkinson's disease is prevalent worldwide but mainly affects the elderly and is rarely seen in women of child-bearing age. The clinical signs and symptoms, the physiological changes of pregnancy, and drug interactions, pose unique challenges for the anaesthetic management of patients with Parkinson's disease who present for delivery. A 36-year-old primigravid woman at 36 weeks' gestation, with Parkinson's disease, presented for pre-anaesthesia assessment prior to elective caesarean section. Her Parkinson's disease had been diagnosed four years previously and was treated with Sinemet (levodopa/carbidopa) and pramipexole...
November 21, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29352501/predictors-of-beef-calf-temperament-at-weaning-and-its-impact-on-temperament-at-breeding-and-reproductive-performance
#3
V R Kasimanickam, R L Abdel Aziz, H M Williams, R K Kasimanickam
Two experiments were conducted to determine (i) factors influencing calf temperament at weaning, (ii) association between heifer-calf temperament at weaning and temperament at breeding and (iii) effect of heifer-calf temperament on pregnancy rate per artificial insemination (P/AI). In experiment 1, beef cows and their calves (n = 285) from three farms were used. Sire docility estimated progeny difference (EPD) score, birth type (normal or assisted), calf gender, calf behaviour (during 1st 4 weeks) and calf health status (until weaning) were recorded...
January 19, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29352267/differential-susceptibility-of-striatal-hippocampal-and-cortical-neurons-to-caspase-6
#4
Anastasia Noël, Libin Zhou, Bénédicte Foveau, P Jesper Sjöström, Andréa C LeBlanc
Active cysteinyl protease Caspase-6 is associated with early Alzheimer and Huntington diseases. Higher entorhinal cortex and hippocampal Caspase-6 levels correlate with lower cognitive performance in aged humans. Caspase-6 induces axonal degeneration in human primary neuron cultures and causes inflammation and neurodegeneration in mouse hippocampus, and age-dependent memory impairment. To assess whether Caspase-6 causes damage to another neuronal system, a transgenic knock-in mouse overexpressing a self-activated form of Caspase-6 five-fold in the striatum, the area affected in Huntington disease, and 2...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29352101/activation-of-disease-during-therapy-with-alemtuzumab-in-3-patients-with-multiple-sclerosis
#5
Thomas Wehrum, Lena-Alexandra Beume, Oliver Stich, Irina Mader, Mathias Mäurer, Adam Czaplinski, Cornelius Weiller, Sebastian Rauer
OBJECTIVE: To report 3 patients with multiple sclerosis showing severe activation of disease during immunotherapy with alemtuzumab. METHODS: Retrospective case series. RESULTS: Patient 1, a 21-year-old woman, developed severe cognitive impairment, sight deterioration, severe gait ataxia, urinary retention, and extensive progression of cerebral lesion load, including new lesions that exhibited gadolinium ring enhancement and dominance of CD19/20-positive B lymphocytes, 6 months after induction of alemtuzumab...
January 19, 2018: Neurology
https://www.readbyqxmd.com/read/29351857/psychometric-properties-of-outcome-measures-evaluating-decline-in-gait-in-cerebellar-ataxia-a-systematic-review
#6
REVIEW
Sarah C Milne, Anna Murphy, Nellie Georgiou-Karistianis, Eppie M Yiu, Martin B Delatycki, Louise A Corben
Cerebellar ataxia often results in impairment in ambulation secondary to gait pattern dysfunction and compensatory gait adjustments. Pharmaceutical and therapy-based interventions with potential benefit for gait in ataxia are starting to emerge, however evaluation of such interventions is hampered by the lack of outcome measures that are responsive, valid and reliable for measurement of gait decline in cerebellar ataxia. This systematic review aimed for the first time to evaluate the psychometric properties of gait and walking outcomes applicable to individuals with cerebellar ataxia...
January 4, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29351494/factors-associated-with-sarcopenia-in-patients-with-colorectal-cancer
#7
Bianca Umbelino de Souza, Nilian Carla Silva Souza, Renata Brum Martucci, Viviane Dias Rodrigues, Nivaldo Barroso de Pinho, Maria Cristina Gonzalez, Carla Maria Avesani
Introduction; Sarcopenia are frequently observed in cancer patients and was associated with poor prognosis. Objectives; to determine the association of nutritional status, body composition, and clinic parameters with sarcopenia in patients with colorectal cancer (CRC). Methods; We conducted a cross-sectional study of 197 patients with CRC. The sarcopenia elements, including lumbar skeletal muscle index (SMI), handgrip strength, and gait speed were measured. The SMI was assessed by computed tomography at third lumbar vertebra...
January 19, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29351127/four-months-of-wearing-a-balance-orthotic-improves-measures-of-balance-and-mobility-among-a-cohort-of-community-living-older-adults
#8
Sean Noah, Cynthia Gibson-Horn, Jennifer L Vincenzo
BACKGROUND AND PURPOSE: The Centers for Disease Control and Prevention estimated that there were 29 million falls and 7 million injuries in 2014 in the United States. Falls, decreased balance, and mobility disability are common in older adults and often result in loss of independence. Finding interventions to address these issues is important, as this age group is growing exponentially. Prior studies indicate balance and mobility can be improved by the balance-based torso-weighting (BBTW) assessment implemented through wear of a balance orthotic (BO)...
January 18, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29351126/incidence-and-risk-factors-for-falls-in-women-with-end-stage-hip-osteoarthritis
#9
Hisashi Ikutomo, Koutatsu Nagai, Keiichi Tagomori, Namika Miura, Norikazu Nakagawa, Kensaku Masuhara
BACKGROUND AND PURPOSE: Fall-induced injuries and resulting deaths are a serious health problem among older adults. The most common risk factors for falls in older adults are muscle weakness, gait deficiencies, and balance deficits. Patients with end-stage hip osteoarthritis (OA) also have many hip dysfunctions, and these all have the potential to increase the risk of falls. However, the incidence and risk factors for falls in patients with end-stage hip OA remain unclear. The aim of this study was to determine the incidence of falls in women with end-stage hip OA and to identify risk factors for falls in this patient population...
January 18, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29351051/voluntary-ambulation-using-voluntary-upper-limb-muscle-activity-and-hybrid-assistive-limb%C3%A2-hal%C3%A2-in-a-patient-with-complete-paraplegia-due-to-chronic-spinal-cord-injury-a-case-report
#10
Yukiyo Shimizu, Hideki Kadone, Shigeki Kubota, Kenji Suzuki, Kousaku Saotome, Tomoyuki Ueno, Tetsuya Abe, Aiki Marushima, Hiroki Watanabe, Ayumu Endo, Kazue Tsurumi, Ryu Ishimoto, Akira Matsushita, Masao Koda, Akira Matsumura, Yoshiyuki Sankai, Yasushi Hada, Masashi Yamazaki
CONTEXT: We sought to describe our experience with the Hybrid Assistive Limb® (HAL®) for active knee extension and voluntary ambulation with remaining muscle activity in a patient with complete paraplegia after spinal cord injury. FINDINGS: A 30-year-old man with complete paraplegia used the HAL® for 1 month (10 sessions) using his remaining muscle activity, including hip flexor and upper limb activity. Electromyography was used to evaluate muscle activity of the gluteus maximus, tensor fascia lata, quadriceps femoris, and hamstring muscles in synchronization with the Vicon motion capture system...
January 19, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29350402/effectiveness-and-safety-of-original-and-generic-sofosbuvir-for-the-treatment-of-chronic-hepatitis-c-a-real-world-study
#11
Sebastián Marciano, Leila Haddad, María Virginia Reggiardo, Mirta Peralta, Cecilia Vistarini, Mónica Marino, Valeria Inés Descalzi, Claudia D'Amico, Sebastián Figueroa Escuti, Luis Alejandro Gaite, Roberto Pérez Ravier, Cristina Longo, Silvia Mabel Borzi, Omar Andrés Galdame, Fernando Bessone, Hugo Alberto Fainboim, Silvia Frías, Mariano Cartier, Adrián Carlos Gadano
We report the first real-world prospective multicenter cohort study that evaluated the effectiveness and safety of original or generic sofosbuvir-based regimens in patients with chronic hepatitis C in Latin America. The main endpoints were assessment of sustained virological response and serious adverse events rates. A total of 321 patients with chronic hepatitis C treated with the following regimens were included: sofosbuvir plus daclatasvir for 12 (n = 34) or 24 (n = 135) weeks, sofosbuvir plus daclatasvir plus ribavirin for 12 (n = 84) or 24 (n = 56) weeks, or sofosbuvir plus ribavirin for 12 (n = 8) or 24 (n = 2) weeks...
January 19, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29350300/the-relationship-between-gait-variability-and-cognitive-functions-differs-between-fallers-and-non-fallers-in-ms
#12
Alon Kalron, Roy Aloni, Mark Dolev, Lior Frid, Uri Givon, Shay Menascu
The objective of the study was to determine if cognitive function is associated with step time variability in people with multiple sclerosis (PwMS). The study included 355 PwMS (218 women), average age 41.1 (SD = 13.5), disease duration 5.9 (SD = 7.3) years, and a median expanded disability status scale score of 2.5. We separately analyzed the sample group of fallers and non-fallers based on their fall history. Gait variability was measured by an electronic walkway and all participants completed a computerized cognitive test battery designed to evaluate multiple cognitive domains...
January 19, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29350089/a-comparative-analysis-of-internal-bone-remodelling-concepts-in-a-novel-implant-for-direct-skeletal-attachment-of-limb-prosthesis-evaluation-a-finite-element-analysis
#13
Piotr Prochor, Eugeniusz Sajewicz
Nowadays, numerous internal bone remodelling concepts are under development, in order to estimate long-term functionality of implants by evaluating the intensity of stress-shielding effect. This effect is also analysed for the implants for direct skeletal attachment, considered as a better exoprosthesis fixation method than prosthetic sockets. Most of bone remodelling approaches are based on basic concepts, differing with certain assumptions, which may affect the accuracy of the results. This article compares commonly used internal bone remodelling concepts and evaluates the functionality of the proposed Limb Prosthesis Osseointegrated Fixation System for direct skeletal attachment of limb prosthesis in comparison with two currently available implants: the Intraosseous Transcutaneous Amputation Prosthesis and the Osseointegrated Prostheses for the Rehabilitation of Amputees...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29348989/signs-and-symptoms-of-acoustic-neuroma-at-initial-presentation-an-exploratory-analysis
#14
Robert W Foley, Shahram Shirazi, Robert M Maweni, Kay Walsh, Rory McConn Walsh, Mohsen Javadpour, Daniel Rawluk
Introduction The objective of this study was to describe the most common clinical features associated with an acoustic neuroma diagnosis and to identify those features associated with larger tumour size at initial diagnosis. Methods The clinical information of 945 consecutive patients diagnosed with acoustic neuroma at a single centre between 1992 and 2015 was analysed. Clinical features were examined and the relationship between these features and tumour size (>2.5 cm) was analysed using descriptive statistics and logistic regression analysis...
November 15, 2017: Curēus
https://www.readbyqxmd.com/read/29348376/-benign-outcome-of-cochlear-implantation-in-a-patient-with-superficial-siderosis
#15
Kei Sato, Takekazu Ohi, Taisaku Shozaki, Shin Kariya
We report the case of a 38-year-old man with gait disorder and hearing loss. The patient had developed gait disorder due to a cervical meningioma since 4 year-old disappeared for 15 years after the surgical removal of the meningioma. However, at the age of 21 year-old, the gait disorder reappeared and worsened progressively. Sensorineural hearing loss (SNHL) and epileptic seizures developed during the disease course, and he was diagnosed with superficial siderosis (SS). When he was 37 years old, he experienced sudden-onset of right-side hearing impairment and was considered a candidate for cochlear implantation (CI) at the otorhinolaryngology clinic of the nearby University Hospital...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29347946/effects-of-long-term-balance-training-with-vibrotactile-sensory-augmentation-among-community-dwelling-healthy-older-adults-a-randomized-preliminary-study
#16
Tian Bao, Wendy J Carender, Catherine Kinnaird, Vincent J Barone, Geeta Peethambaran, Susan L Whitney, Mohammed Kabeto, Rachael D Seidler, Kathleen H Sienko
BACKGROUND: Sensory augmentation has been shown to improve postural stability during real-time balance applications. Limited long-term controlled studies have examined retention of balance improvements in healthy older adults after training with sensory augmentation has ceased. This pilot study aimed to assess the efficacy of long-term balance training with and without sensory augmentation among community-dwelling healthy older adults. METHODS: Twelve participants (four males, eight females; 75...
January 18, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29347868/differential-white-matter-regional-alterations-in-motor-subtypes-of-early-drug-naive-parkinson-s-disease-patients
#17
Ming-Ching Wen, Hannah S E Heng, Zhonghao Lu, Zheyu Xu, Ling Ling Chan, Eng King Tan, Louis C S Tan
BACKGROUND: Parkinson's disease (PD) can be classified into tremor dominant (TD) and postural instability and gait difficulty (PIGD) subtypes with TD considered as the benign subtype. The neural alterations of the 2 subtypes in the early stages before administration of medications remain elusive. OBJECTIVE: This study assessed the subtype-related white matter (WM) microstructural features in newly diagnosed and drug-naive PD patients from the Parkinson's Progression Markers Initiative (PPMI)...
January 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29347300/swimming-efficiency-in-a-shear-thinning-fluid
#18
Herve Nganguia, Kyle Pietrzyk, On Shun Pak
Micro-organisms expend energy moving through complex media. While propulsion speed is an important property of locomotion, efficiency is another factor that may determine the swimming gait adopted by a micro-organism in order to locomote in an energetically favorable manner. The efficiency of swimming in a Newtonian fluid is well characterized for different biological and artificial swimmers. However, these swimmers often encounter biological fluids displaying shear-thinning viscosities. Little is known about how this nonlinear rheology influences the efficiency of locomotion...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346526/what-is-the-impact-of-physical-activity-and-physical-function-on-the-development-of-multimorbidity-in-older-adults-over-time-a-population-based-cohort-study
#19
Aine Ryan, Catriona Murphy, Fiona Boland, Rose Galvin, Susan M Smith
Background: Multimorbidity is recognised internationally as having a serious impact on health outcomes. It is associated with reduced quality of life, increased healthcare utilisation and future functional decline. Physical activity is associated with good health and psychological well-being. The aim of this study was to identify the impact of physical activity and physical function on the development and worsening of multimorbidity over time. Methods: Using The Irish Longitudinal Study on Ageing (TILDA), we analysed 4,823 participants >50 years with and without multimorbidity...
January 13, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29346523/timed-up-and-go-test-and-future-dementia-occurrence
#20
Ji Eun Lee, Dong Wook Shin, Su-Min Jeong, Ki Young Son, Belong Cho, Jong Lull Yoon, Byung Joo Park, In Soon Kwon, Jinkook Lee, SangYun Kim
Background: This study evaluated whether baseline results of the Timed Up and Go (TUG) test is associated with future dementia occurrence. Methods: Using the Korean National Health Insurance Service-National Health Screening Cohort database, we identified 49 283 subjects without a dementia diagnosis who participated in the National Screening Program for Transitional Ages at 66 years of age during 2007-2012. Gait impairment was defined as taking longer than 10 seconds to perform the TUG test...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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