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https://www.readbyqxmd.com/read/29436405/neutrophil-to-lymphocyte-ratio-and-clinical-outcomes-in-copd-recent-evidence-and-future-perspectives
#1
REVIEW
Panagiotis Paliogiannis, Alessandro G Fois, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Zinellu, Pietro Pirina, Silvia Negri, Ciriaco Carru, Angelo Zinellu
Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29429770/structural-airway-abnormalities-contribute-to-dysphagia-in-children-with-esophageal-atresia-and-tracheoesophageal-fistula
#2
Katherine J Baxter, Lauren M Baxter, April M Landry, Mark L Wulkan, Amina M Bhatia
BACKGROUND: Long-term dysphagia occurs in up to 50% of repaired esophageal atresia and tracheoesophageal fistula (EA/TEF) patients. The underlying factors are unclear and may include stricture, esophageal dysmotility, or associated anomalies. Our purpose was to determine whether structural airway abnormalities (SAA) are associated with dysphagia in EA/TEF. METHODS: We conducted a retrospective chart review of children who underwent EA/TEF repair in our hospital system from 2007 to 2016...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29428348/creation-and-initial-validation-of-the-international-dysphagia-diet-standardisation-initiative-functional-diet-scale
#3
Catriona M Steele, Ashwini M Namasivayam-MacDonald, Brittany T Guida, Julie A Y Cichero, Janice Duivestein, Ben Hanson, Peter Lam, Luis F Riquelme
OBJECTIVE: To assess consensual validity, inter-rater reliability and criterion validity of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale (IDDSI-FDS), a new functional outcome scale intended to capture the severity of oropharyngeal dysphagia, as represented by the degree of diet texture restriction recommended for the patient. DESIGN: Participants assigned IDDSI-FDS scores to 16 clinical cases. Consensual validity was measured against reference scores determined by an author reference panel...
February 8, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29412517/plasma-proteomic-signatures-in-early-chronic-obstructive-pulmonary-disease
#4
Angela Baralla, Alessandro G Fois, Elisabetta Sotgiu, Elisabetta Zinellu, Arduino A Mangoni, Salvatore Sotgia, Angelo Zinellu, Pietro Pirina, Ciriaco Carru
PURPOSE: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and abnormal inflammatory response of the lungs to inhaled noxious particles or gases. We used a proteomic approach with 2-DE followed by MALDI TOF-MS analyses in order to identify potential biomarkers in the early stages of the disease: GOLD stage mild and moderate. EXPERIMENTAL DESIGN: Blood plasma was collected from 43 patients with mild and moderate COPD as well as from 43 age and sex matched control subjects...
February 7, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29404691/interdisciplinary-telemedicine-in-the-management-of-dysphagia-in-head-and-neck
#5
Mydhili Mayadevi, Krishnakumar Thankappan, Shashikant Vishnubhai Limbachiya, Sivakumar Vidhyadharan, Brenda Villegas, Melody Ouyoung, Deepak Balasubramanian, Jayakumar R Menon, Uttam Sinha, Subramania Iyer
The study considered the feasibility and impact of interdisciplinary telemedicine discussions in the management of post-treatment dysphagia in patients with head and neck tumors. This is a retrospective analysis of patients with persistent dysphagia after treatment for head and neck pathology, at an institute in India. The cases were discussed in the telemedicine meeting conducted between host institute and a second unit in the United States. A monthly meeting was organized, using an internet-based video conference system...
February 5, 2018: Dysphagia
https://www.readbyqxmd.com/read/29400665/noninvasive-quantitative-assessment-of-microcirculatory-disorders-of-the-upper-extremities-with-2d-fluorescence-optical-imaging
#6
Jan Neumann, Christoph Schmaderer, Sebastian Finsterer, Alexander Zimmermann, Dominik Steubl, Anne Helfen, Markus Berninger, Fabian Lohöfer, Ernst J Rummeny, Reinhard Meier, Moritz Wildgruber
BACKGROUND: Quantitative Imaging of microcirculatory disorders is challenging. OBJECTIVE: To investigate the feasibility of 2D Fluorescence Optical Imaging (FOI) for characterization and quantification of microcirculatory disorders in peripheral arterial occlusive disease (PAOD) of the upper extremity. METHODS: 9 patients with various clinical presentations of PAOD of the upper extremity were included. Quantitative analysis of both hands was performed by assessing the fluorescence intensity of Indocyanine Green (ICG) dynamically over a time period of 360 seconds...
February 2, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29382988/bone-regeneration-with-recombinant-human-bone-morphogenetic-protein-2-a-systematic-review
#7
REVIEW
Jannice de Queiroz Fernandes, Valthierre Nunes de Lima, João Paulo Bonardi, Osvaldo Magro Filho, Sormani Bento Fernandes Queiroz
Aim: The aim of this work was to perform a systematic literature review on the clinical application of rhBMP-2 in bone reconstruction prior to placing implants. Materials and Methods: A PUBMED search was made about the subject and nine clinical trials were selected according to strict inclusion criteria. Results: Overall success rates of bone regeneration with rhBMP-2 was 81.4% and success of implants placed was 87.4%. Most frequent adverse events were pain, edema and erythema...
March 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29366958/trace-elements-in-als-patients-and-their-relationships-with-clinical-severity
#8
Riccardo Oggiano, Giuliana Solinas, Giovanni Forte, Beatrice Bocca, Cristiano Farace, Andrea Pisano, Maria Alessandra Sotgiu, Simonetta Clemente, Michele Malaguarnera, Alessandro Giuseppe Fois, Pietro Pirina, Andrea Montella, Roberto Madeddu
An exploratory study of trace elements in ALS and their relationships with clinical severity was detected. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that causes irreversible damage in humans, with the consequent loss of function of motoneurons (MNs), with a prognosis up to 5 years after diagnosis. Except to genetic rare cases it is not known the etiology of the disorder. Aim of our research is to investigate the possible role of heavy metals in the severity of the disease. In this study, by the use of plasma mass (ICP-MS), we have analyzed the content of essential and heavy metals such: Pb, Cd, Al, Hg, Mn, Fe, Cu, Zn, Se, Mg, and Ca, in blood, urine and hair of ALS patients and controls; moreover we divided the patients in two groups for disease severity and analyzed the difference among the groups, in order to study a possible involvement of metals in the severity of the damage...
January 16, 2018: Chemosphere
https://www.readbyqxmd.com/read/29360061/pulse-steroid-therapy-in-multiple-sclerosis-and-mood-changes-an-exploratory-prospective-study
#9
Lorena Lorefice, Giuseppe Fenu, Michela Fois, Jessica Frau, Giancarlo Coghe, Maria Giovanna Marrosu, Eleonora Cocco
BACKGROUND: Several reports suggest a higher risk of psychiatric disorders after high-dose corticosteroids (HDC), routinely used to treat clinical relapses in multiple sclerosis (MS). The present study aimed to examine the possible effect of HDC on mood in patients with MS and to determine the specific factors that influence mood changes. METHODS: The study included MS patients prior to receive HDC. The presence of depressive and bipolar symptoms was determined with the Beck Depression Inventory-Second Edition (BDI-II) and the Mood Disorder Questionnaire (MDQ)...
January 18, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29356657/entre-d%C3%A3-tresse-psychologique-et-sant%C3%A3-mentale-positive-le-cas-des-travailleurs-de-la-restauration
#10
Samantha Vila Masse
OBJECTIF: Examiner le lien entre les conditions de travail et la santé mentale des travailleurs-euses de la restauration.MÉTHODE : L'échantillon se compose de 652 travailleurs-euses de la restauration issus de l'ESCC-SM de 2012. Des analyses de régression linéaire hiérarchique sont effectuées et ajustées en fonction de divers facteurs sélectionnés (sociodémographiques, habitudes de vie). Les conditions de travail sont mesurées en partie selon le Job Content Questionnaire (JCQ) de Karasek et Theorell...
January 22, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29288590/combined-electrical-stimulation-and-exercise-for-swallow-rehabilitation-post-stroke-a-pilot-randomized-control-trial
#11
Lise Sproson, Sue Pownall, Pam Enderby, Jenny Freeman
BACKGROUND: Dysphagia is common after stroke, affecting up to 50% of patients initially. It can lead to post-stroke pneumonia, which causes 30% of stroke-related deaths, a longer hospital stay and poorer health outcomes. Dysphagia care post-stroke generally focuses on the management of symptoms, via modified oral intake textures and adapted posture, rather than direct physical rehabilitation of the swallowing function. Transcutaneous neuromuscular electrical stimulation (NMES) is a promising rehabilitation technology that can be used to stimulate swallowing; however, findings regarding efficacy have been conflicting...
December 30, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29282210/atp-is-stored-in-lamellar-bodies-to-activate-vesicular-p2x4-in-an-autocrine-fashion-upon-exocytosis
#12
Giorgio Fois, Veronika Eva Winkelmann, Lara Bareis, Laura Staudenmaier, Elena Hecht, Charlotte Ziller, Konstantin Ehinger, Jürgen Schymeinsky, Christine Kranz, Manfred Frick
Vesicular P2X4 receptors are known to facilitate secretion and activation of pulmonary surfactant in the alveoli of the lungs. P2X4 receptors are expressed in the membrane of lamellar bodies (LBs), large secretory lysosomes that store lung surfactant in alveolar type II epithelial cells, and become inserted into the plasma membrane after exocytosis. Subsequent activation of P2X4 receptors by adenosine triphosphate (ATP) results in local fusion-activated cation entry (FACE), facilitating fusion pore dilation, surfactant secretion, and surfactant activation...
December 27, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29223113/comparisons-of-severity-classification-systems-for-oropharyngeal-dysfunction-in-children-with-cerebral-palsy-relations-with-other-functional-profiles
#13
Yu-Ra Goh, Ja Young Choi, Seon Ah Kim, Jieun Park, Eun Sook Park
This study aimed to investigate the relationships between various classification systems assessing the severity of oropharyngeal dysphagia and communication function and other functional profiles in children with cerebral palsy (CP). This is a prospective, cross-sectional, study in a university-affiliated, tertiary-care hospital. We recruited 151 children with CP (mean age 6.11 years, SD 3.42, range 3-18yr). The Eating and Drinking Ability Classification System (EDACS) and the dysphagia scales of Functional Oral Intake Scale (FOIS), Swallow Function Scales (SFS), and Food Intake Level Scale (FILS) were used...
December 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29217897/long-lasting-dysphagia-developing-after-thoracotomy-for-pulmonary-resection-a-case-series
#14
Ikuno Ito, Kohei Hamada, Hiroyuki Sato, Naoko Shindo
The purpose of this study was to retrospectively evaluate the severity and the characteristics of dysphagia using videofluoroscopic swallowing studies (VFSS) in long-lasting dysphagia patients developing after thoracotomy performed for pulmonary resection. Eleven patients (10 men and 1 woman, average age 67 ± 6.6 years; the average operation time in the patients was 507 min) were selected from among patients who developed dysphagia after undergoing thoracotomy for pulmonary resection between January 2009 and December 2012...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29170319/22%C3%A2-emergency-department-litigation-and-coroner-s-inquests-a-ten-year-analysis
#15
Nicholas Tilbury, Andrew Tabner, Graham Johnson
INTRODUCTION: The burden of litigation within the NHS should not be underestimated. Indemnity costs rise in response to the rising frequency and costs of claims, with recent changes to the discount rate projected to increase NHS Litigation Authority (NHSLA) costs by £1 Billion per year. Litigation also has a significant psychological impact on staff. This study represents the first examination of litigation and Coroner's 'Prevention of Future Deaths' reports relating to emergency department care in the UK...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29168360/does-nissen-fundoplication-improve-deglutition-in-children
#16
Tutku Soyer, Şule Yalçın, Numan Demir, Asuman Nur Karhan, İnci Nur Saltık-Temizel, Hülya Demir, Feridun Cahit Tanyel
Soyer T, Yalçın Ş, Demir N, Karhan AN, Saltık-Temizel İN, Demir H, Tanyel FC. Does Nissen fundoplication improve deglutition in children? Turk J Pediatr 2017; 59: 28-34. A prospective study was performed to evaluate the effect of Nissen fundoplication (NF) on deglutition in children. Children who underwent NF between 2011-2015 were evaluated for demographic features, clinical findings, diagnostic methods for gastroesophageal reflux (GER) and indications for NF. Penetration aspiration scale (PAS), functional oral intake scale (FOIS) and esophageal functions were evaluated by videoflouroscopy (VFS)...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29167414/biomarkers-related-to-respiratory-symptoms-and-lung-function-in-adults-with-asthma
#17
Lucia Calciano, Laura Portas, Angelo Guido Corsico, Mario Olivieri, Paolo Degan, Marcello Ferrari, Alessandro Fois, Anna Maria Fratta Pasini, Andrea Pasini, Maria Elisabetta Zanolin, Roberto de Marco, Simone Accordini
There is a need for easily measurable biomarkers that are able to identify different levels of asthma severity. Aim. To assess the association between peripheral blood cell counts, fractional nitric oxide in exhaled air (FeNO), urinary biomarkers of oxidative stress (8-hydroxy-2'-deoxyguanosine and 8-isoprostane), and asthma severity in adult patients from the general population. Methods. In the Gene Environment Interactions in Respiratory Diseases study, 287 subjects with asthma (aged 20-64) were identified from the general population in Verona (Italy) (2008-2010)...
November 23, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29164705/molecular-engineering-of-mn-ii-diamine-diketonate-precursors-for-the-vapor-deposition-of-manganese-oxide-nanostructures
#18
Chiara Maccato, Lorenzo Bigiani, Giorgio Carraro, Alberto Gasparotto, Roberta Seraglia, Jiyeon Kim, Anjana Devi, Gloria Tabacchi, Ettore Fois, Giuseppe Pace, Vito Di Noto, Davide Barreca
Molecular engineering of manganese(II) diamine diketonate precursors is a key issue for their use in the vapor deposition of manganese oxide materials. Herein, two closely related β-diketonate diamine Mn(II) adducts with different fluorine contents in the diketonate ligands are examined. The target compounds were synthesized by a simple procedure and, for the first time, thoroughly characterized by a joint experimental-theoretical approach, to understand the influence of the ligand on their structures, electronic properties, thermal behavior, and reactivity...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29158848/biodegradable-core-shell-dual-metal-organic-frameworks-nanotheranostic-agent-for-multiple-imaging-guided-combination-cancer-therapy
#19
Dongdong Wang, Jiajia Zhou, Ruohong Shi, Huihui Wu, Ruhui Chen, Beichen Duan, Guoliang Xia, Pengping Xu, Hui Wang, Shu Zhou, Chengming Wang, Haibao Wang, Zhen Guo, Qianwang Chen
Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach...
2017: Theranostics
https://www.readbyqxmd.com/read/29158670/interferential-current-sensory-stimulation-through-the-neck-skin-improves-airway-defense-and-oral-nutrition-intake-in-patients-with-dysphagia-a-double-blind-randomized-controlled-trial
#20
Keisuke Maeda, Takayuki Koga, Junji Akagi
Background: Neuromuscular electrical stimulation with muscle contraction, administered through the skin of the neck, improves a patient's swallowing ability. However, the beneficial effects of transcutaneous electrical sensory stimulation (TESS), without muscle contraction, are controversial. We investigated the effect of TESS, using interferential current, in patients undergoing dysphagia rehabilitation. Methods: This double-blind, randomized controlled trial involved 43 patients who were prescribed in-hospital dysphagia rehabilitation for ≥3 weeks...
2017: Clinical Interventions in Aging
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