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Nasopharyngeal cancer

Yavuz Dodurga, Mücahit Seçme, N Lale Şatıroğlu-Tufan
Oncogenes are mutated form of normal cellular genes called as proto-oncogenes and conduce to the cancer development process. Despite the fact that so many genes have been described, new genes with oncogenic characteristic and potential or tumor supressoring activity are still being defined. Recently, Up-regulated gene 4/Upregulator of cell proliferation (URG4/URGCP), a novel gene, induced by hepatitis-Bvirus-encoded X antigen (HBxAg), has been identified. URG4/URGCP gene was registered to the National Center for Biotechnology Information-GenBank (NCBI-GenBank, Entrez GeneID: 55665 and Entrez Nucleotide ID NM_017920)...
May 15, 2018: Gene
Yim Ling Yip, Weitao Lin, Wen Deng, Lin Jia, Kwok Wai Lo, Pierre Busson, Benjamin Vérillaud, Xuefeng Liu, Chi Man Tsang, Maria Li Lung, Sai Wah Tsao
Epstein-Barr virus (EBV) infects more than 90% of the adult human population. Undifferentiated nasopharyngeal carcinoma (NPC) is common in Southeast Asia, with a particularly high incidence among southern Chinese. The EBV genome can be detected in practically all cancer cells in undifferentiated NPC. The role of EBV in pathogenesis of undifferentiated NPC remains elusive. NPC cell lines are known to be difficult to establish in culture. The EBV+ve NPC cell lines, even if established in culture, rapidly lost their EBV episomes upon prolonged propagation...
May 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
Daniel D Von Hoff, Drew W Rasco, Elisabeth I Heath, Pamela N Munster, Jan H M Schellens, Nicolas Isambert, Christophe Le Tourneau, Bert H O'Neil, Ron Hj Mathijssen, Jose A Lopez-Martin, William J Edenfield, Miguel Martín, Patricia M LoRusso, Gordon L Bray, Jorge DiMartino, Aaron Nguyen, Kejian Liu, Eric Laille, Johanna C Bendell
PURPOSE: This large two-part, three-arm phase I study examined the safety and tolerability of CC-486 (an oral formulation of azacitidine, a hypomethylating agent) alone or in combination with the cytotoxic agents, carboplatin or nab-paclitaxel, in patients with advanced unresectable solid tumors. PATIENTS AND METHODS: Part 1 (n=57) was a dose escalation of CC-486 alone (arm C) or with carboplatin (arm A) or nab-paclitaxel (arm B). The primary endpoint was safety, maximum tolerated dose, and recommended part 2 dose (RP2D) of CC-486...
May 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Long-Jun He, Chuanbo Xie, Yin Li, Lin-Na Luo, Ke Pan, Xiao-Yan Gao, Li-Zhi Liu, Jian-Ming Gao, Guang-Yu Luo, Hong-Bo Shan, Ming-Yuan Chen, Chong Zhao, Wei-Jun Fan, Ping Yang, Guo-Liang Xu, Jian-Jun Li
BACKGROUND: Enlarged retropharyngeal lymph nodes (RLNs) are very common in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The most suitable treatment option for enlarged RLNs depends on the pathological results. However, RLN sampling is difficult and imminent in the clinic setting. We recently developed a novel minimally invasive technique termed endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for sampling RLN tissues sufficient for pathological or cytological diagnosis...
May 9, 2018: Cancer communications
Cheng-Fu Cai, Guo-Dong Ye, Dong-Yan Shen, Wei Zhang, Mao-Li Chen, Xin-Xin Chen, Da-Xiong Han, Yan-Jun Mi, Qi-Cong Luo, Wang-Yu Cai, Shu-Yu Yang
BACKGROUND: Great progress has been achieved in the study of the aerobic glycolysis or the so-called Warburg effect in a variety of cancers; however, the regulation of the Warburg effect in Nasopharyngeal carcinoma (NPC) has not been completely defined. METHODS: Gene expression pattern of NPC cells were used to test associations between Chibby and β-catenin expression. Chibby siRNAs and over-expression vector were transfected into NPC cells to down-regulate or up-regulate Chibby expression...
May 15, 2018: Journal of Experimental & Clinical Cancer Research: CR
W K Jacky Lam, Peiyong Jiang, K C Allen Chan, Suk H Cheng, Haiqiang Zhang, Wenlei Peng, O Y Olivia Tse, Yu K Tong, Wanxia Gai, Benny C Y Zee, Brigette B Y Ma, Edwin P Hui, Anthony T C Chan, John K S Woo, Rossa W K Chiu, Y M Dennis Lo
Circulating tumor-derived DNA testing for cancer screening has recently been demonstrated in a prospective study on identification of nasopharyngeal carcinoma (NPC) among 20,174 asymptomatic individuals. Plasma EBV DNA, a marker for NPC, was detected using real-time PCR. While plasma EBV DNA was persistently detectable in 97.1% of the NPCs identified, ∼5% of the general population had transiently detectable plasma EBV DNA. We hypothesized that EBV DNA in plasma of subjects with or without NPC may have different molecular characteristics...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
Daoyuan Gong, Ziping Li, Rui Ding, Min Cheng, Huakun Huang, Aiping Liu, Mei Kang, Haijian He, Ying Xu, Jing Shao, Yong Wang, Chaohui Duan
Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC patient serum using a solid-phase antibody array detecting the expression profiles of 174 cytokines in a single experiment. ELISA was performed to validate the array results. The levels of TIMP-2, SELL, CCL24, MMP-1, MMP-3, IGF-I and IL-8 were significantly higher in serum from NPC patients, while the levels of MSP-alpha and HCC-4 were lower...
May 11, 2018: Cytokine
Warren R Bacorro, Ryan Anthony F Agas, Stellar Marie R Cabrera, Maureen R Bojador, Paolo G Sogono, Michael Benedict A Mejia, Teresa T Sy Ortin
PURPOSE: In nasopharyngeal cancer, brachytherapy is given as boost in primary treatment or as salvage for recurrent or persistent disease. The Rotterdam nasopharyngeal applicator (RNA) allows for suboptimal reduction of soft palate radiation dose, based on image-guided brachytherapy plans. Building on the RNA, we propose a novel design, the Benavides nasopharyngeal applicator (BNA). METHODS AND MATERIALS: The virtual BNA was reconstructed on two cases (one T1, one T2) previously treated with intracavitary brachytherapy using the RNA...
May 11, 2018: Brachytherapy
Jia-Shing Wu, Yu-Chen Tsai, James Jer-Min Jian, Hsin-Hsuan Chen, Cheng-Fang Horng, Skye Hung-Chun Cheng
BACKGROUND: The role of adjuvant chemotherapy after concurrent chemoradiotherapy (CRT) for nasopharyngeal carcinoma (NPC) is controversial. We report our phase II prospective study of withholding adjuvant chemotherapy in a subgroup of patients with American Joint Committee on Cancer (AJCC) stage II and III NPC with low risk for metastasis. METHODS: Between April 1998 and December 2008, 263 patients with stage II (AJCC 1997 T2aN0, T1-T2aN1; AJCC 2010 T1N1) NPC or stage III (AJCC 1997 T1-T2aN2; AJCC 2010 T1N2) NPC were enrolled...
May 13, 2018: Head & Neck
Gengming Wang, Lei Zhang, Yan Zhou, Qian Sun, Hongbo Xu, Feng Cai, Ping Xiang, Zhendong Chen, Hao Jiang
BACKGROUND Endothelial progenitor cells (EPCs) are regarded as promising targeted vectors for delivering therapeutic genes or agents in cancer therapy. The purpose of this study was to investigate the role of intravenously administered KAI1/CD82 genetically transduced EPCs in the tumorigenesis and metastasis of nasopharyngeal carcinoma (NPC). MATERIAL AND METHODS EPCs were isolated from human umbilical cord blood, expanded in culture, and stably transduced with lentiviral vectors expressing KAI1/CD82. The KAI1/CD82 EPCs were injected intravenously into nude mice bearing human NPC xenografts...
May 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
A Dimitrios Colevas, Sue S Yom, David G Pfister, Sharon Spencer, David Adelstein, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Maura L Gillison, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the H&N, and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding evaluation and treatment of nasopharyngeal carcinoma...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Chawalit Lertbutsayanukul, Sarin Kitpanit, Anussara Prayongrat, Danita Kannarunimit, Buntipa Netsawang, Chakkapong Chakkabat
This study aimed to validate previously reported dosimetric parameters, including thyroid volume, mean dose, and percentage thyroid volume, receiving at least 40, 45 and 50 Gy (V40, V45 and V50), absolute thyroid volume spared (VS) from 45, 50 and 60 Gy (VS45, VS50 and VS60), and clinical factors affecting the development of radiation-induced hypothyroidism (RHT). A post hoc analysis was performed in 178 euthyroid nasopharyngeal cancer (NPC) patients from a Phase III study comparing sequential versus simultaneous-integrated boost intensity-modulated radiation therapy...
May 10, 2018: Journal of Radiation Research
Chiao-Fan Lin, Hsiang-Lin Chan, Yi-Hsuan Hsieh, Hsin-Yi Liang, Wei-Che Chiu, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen
Background: The association between antidepressant exposure and nasopharyngeal cancer (NPC) has not been previously explored. The purpose of this study was to investigate the association between antidepressant prescription, including novel antidepressants, and the risk of NPC in a population-based study. Materials and methods: Data for the analysis were derived from National Health Insurance Research Database. We identified 16,957 cases with a diagnosis of NPC and 83,231 matched controls by using a nested case-control design...
2018: Neuropsychiatric Disease and Treatment
Peng Wang, Na Shen, Danzheng Liu, Xianhui Ning, Daquan Wu, Xinsheng Huang
Nasopharyngeal carcinoma (NPC) is a common cancer occurring primarily in East Asia and Africa. The high rate of recurrence and metastasis of NPC continuously endangers the health of patients. The present study aimed to identify the underlying mechanisms involved in the progression of NPC and provide experimental basis to develop a novel and efficient agent against NPC. The present study measured the expression level of tripartite motif containing 24 (TRIM24) in tumor tissues from NPC patients using reverse transcription quantitative polymerase chain reaction...
May 2, 2018: Molecular Medicine Reports
Hui-Jie Zhang, Gao-Le Yuan, Qi-Lian Liang, Xiao-Xia Peng, Shao-Ang Cheng, Liang Jiang
Radiotherapy is a vital treatment option for patients with nasopharyngeal carcinoma (NPC). Concurrent cisplatin-based radiochemotherapy with or without adjuvant chemotherapy had acquired good clinical effects with good local control rates. However, a number of patients present with metastasis following systemic regimens or initial diagnosis of locally advanced NPC, which cause difficulty for subsequent therapy. Therefore, there is an urgent requirement to discover novel targeted therapies. The present report describes one case of a patient with NPC and multiple metastases...
May 2018: Oncology Letters
Chien-Hung Lin, Ming-Chang Chiang, Yann-Jang Chen
Background: MicroRNAs (miRNAs) play crucial roles in various types of cancers, particularly in tumor development, migration, and progression. Dysregulation of miR-328 was reported to occur in some types of human malignancies, however, the role of miR-328 in nasopharyngeal carcinoma (NPC) and its potential involvement in metastasis remain undetermined. Methods: The invasion capacity of NPC sphere-forming cells was evaluated by in vitro cell migration assays. Differential miRNAs expression was examined in NPC sphere-forming cells compared to parental monolayer cells using miRNA array analysis...
2018: OncoTargets and Therapy
Lin Xia, Wei Zhang, Linyan Zhu, Guozheng Yu
BACKGROUND: Dysregulated long non-coding RNAs (lncRNAs) have been extensively explored in nasopharyngeal carcinoma (NPC) research. The current study focused on elucidating the overall diagnostic and prognostic performances of abnormally expressed lncRNAs in NPC. METHODS: We performed a systematic literature search based on the online databases. The pooled effects sizes for diagnosis and prognosis were synthesized using a fixed or random effect model. Hazard ratios (HRs) with 95% confidence intervals (CIs) for primary endpoints of overall survival (OS) and disease-free survival (DFS) were aggregated...
April 1, 2018: Clinical Laboratory
Kun-Chun Chiang, Shih-Wei Yang, Kai-Ping Chang, Tsui-Hsia Feng, Kang-Shuo Chang, Ke-Hung Tsui, Yi-Syuan Shin, Chiu-Chun Chen, Mei Chao, Horng-Heng Juang
Caffeic acid phenethyl ester (CAPE), a bioactive component extracted from propolis, is widely studied due to its anti-cancer effect. Nasopharyngeal carcinoma (NPC) is distinct from other head and neck carcinomas and has a high risk of distant metastases. N -myc downstream regulated gene 1 (NDRG1) is demonstrated as a tumor suppressor gene in several cancers. Our result showed that CAPE treatment could repress NPC cell growth, through induction of S phase cell cycle arrest, and invasion. CAPE treatment stimulated NDRG1 expression in NPC cells...
May 8, 2018: International Journal of Molecular Sciences
Chengcheng Deng, Yu-Xin Lin, Xue-Kang Qi, Gui-Ping He, Yuchen Zhang, Hao-Jiong Zhang, Miao Xu, Qi-Sheng Feng, Jin-Xin Bei, Yi-Xin Zeng, Lin Feng
Genetic susceptibility underlies the pathogenesis of cancer. We and others have previously identified a novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. Here we show that TNFRSF19 is highly expressed in NPC and is required for cell proliferation and NPC development. However, unlike most of TNF receptors, TNFRSF19 was not involved in NF-κB activation or associated with TRAF proteins...
May 7, 2018: Cancer Research
Jin Hou, HuiMin Zheng, Pan Li, HaiYue Liu, HongWei Zhou, XiaoJun Yang
BACKGROUND AND PURPOSE: Oral mucositis remains one of the most common complications of radiation therapy for patients with head and neck cancer. This study aimed to investigate the dynamic shifts in the oral mucosal microbiota and their association with the progression and aggravation of mucositis in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. MATERIALS AND METHODS: In this study, oropharyngeal mucosa of patients were examined regularly, and sampled longitudinally in eight stages of their radiation treatment program: before radiation, and then after 10, 20, 30, 40, 50, 60, and 70 Gy...
May 4, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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