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Nasopharyngeal cancer

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https://www.readbyqxmd.com/read/28335242/targeting-and-photodynamic-killing-of-cancer-cell-by-nitrogen-doped-titanium-dioxide-coupled-with-folic-acid
#1
Jin Xie, Xiaobo Pan, Mengyan Wang, Longfang Yao, Xinyue Liang, Jiong Ma, Yiyan Fei, Pei-Nan Wang, Lan Mi
Titanium dioxide (TiO₂) has attracted wide attention as a potential photosensitizer (PS) in photodynamic therapy (PDT). However, bare TiO₂ can only be excited by ultraviolet illumination, and it lacks specific targeting ligands, which largely impede its application. In our study, we produced nitrogen-doped TiO₂ and linked it with an effective cancer cell targeting agent, folic acid (FA), to obtain N-TiO₂-FA nanoconjugates. Characterization of N-TiO₂-FA included Zeta potential, absorption spectra and thermogravimetric analysis...
June 14, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331336/gstm1-polymorphism-is-related-to-risks-of-nasopharyngeal-cancer-and-laryngeal-cancer-a-meta-analysis
#2
REVIEW
Fengying Zhang, Xijiang Wu, Jinming Niu, Xiufeng Kang, Liya Cheng, Yanchun Lv, Meimei Wu
BACKGROUND: Accumulating data have reported that GSTM1 polymorphism may be related to nasopharyngeal cancer (NPC) and laryngeal cancer (LC). This meta-analysis was performed to investigate the relationship between GSTM1 polymorphism and risks of NPC and LC. METHODS: Pubmed, Embase, and China National Knowledge Infrastructure (CNKI) databases were searched for potential articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the relationship of GSTM1 polymorphism with the risks of NPC and LC...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28323051/anticancer-and-anti-angiogenic-activities-of-extract-from-actinidia-eriantha-benth-root
#3
Jian-Guo Wu, Li Ma, Shui-Hua Lin, Yan-Bin Wu, Jun Yi, Bin-Jun Yang, Jin-Zhong Wu, Ka-Hing Wong
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Actinidia eriantha Benth (AER) are commonly used traditional folk medicine for the treatment of gastric carcinoma, nasopharyngeal carcinoma, and breast carcinoma. Besides, the anti-proliferative and immunomodulatory effects of AER polysaccharides on tumor-bearing mice have been reported previously. AIM OF THE STUDY: This work was carried out to investigate the anticancer and anti-angiogenic activities of AER. MATERIALS AND METHODS: The growth inhibitory effects of ethanol extracts from the leaves (EEL), stems (EES) and roots (EER) of A...
March 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28315691/mir-519-suppresses-nasopharyngeal-carcinoma-cell-proliferation-by-targeting-oncogene-urg4-urgcp
#4
Guodong Yu, Tian Zhang, Ying Jing, Qingmin Bao, Qiang Tang, Yu Zhang
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumor in Southeast Asia, its regulatory mechanism is still to be understood. miR-519 inhibits the progression of several tumors, including cervical cancer, ovarian cancer and gastric cancer. But its role in NPC hasn't been studied. In present study, we found miR-519 was downregulated in NPC cells, its overexpression inhibited NPC cell proliferation and arrested cell cycle at G0/G1 phase, while its knockdown promoted NPC cell proliferation and cell cycle progression...
March 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28301518/cyclooxygenase-2-expression-is-positively-associated-with-lymph-node-metastasis-in-nasopharyngeal-carcinoma
#5
Gui Yang, Qiaoling Deng, Wei Fan, Zheng Zhang, Peipei Xu, Shihui Tang, Ping Wang, Jun'e Wang, Mingxia Yu
BACKGROUND: Accumulating evidence has demonstrated that cyclooxygenase-2 (COX-2) is involved in head and neck cancers, especially in nasopharyngeal carcinoma (NPC). However, the association between COX-2 expression and lymph node metastasis in NPC remains uncertain. This systematic review and meta-analysis meta-analysis investigated the relationship between COX-2 expression and lymph node metastasis and other signs of disease progression in NPC. METHODS: Previously published studies assessing COX-2 expression and lymph node metastasis in NPC were identified in four English databases and three Chinese ones (Pubmed, Embase, Cochrane Database of Systematic Reviews, Web of Science, China National Knowledge Infrastructure, Wanfang, Vip Journal Integration Platform) up to November 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28300368/reduction-in-stray-radiation-dose-using-a-body-shielding-device-during-external-radiation-therapy
#6
Shuxu Zhang, Shaohui Jiang, Quanbin Zhang, Shengqu Lin, Ruihao Wang, Xiang Zhou, Guoqian Zhang, Huaiyu Lei, Hui Yu
With the purpose of reducing stray radiation dose (SRD) in out-of-field region (OFR) during radiotherapy with 6 MV intensity-modulated radiation therapy (IMRT), a body-shielding device (BSD) was prepared according to the measurements obtained in experimental testing. In experimental testing, optimal shielding conditions, such as 1 mm lead, 2 mm lead, and 1 mm lead plus 10 mm bolus, were investigated along the medial axis of a phantom using thermoluminescent dosimeters (TLDs). The SRDs at distances from field edge were then measured and analyzed for a clinical IMRT treatment plan for nasopharyngeal carcinoma before and after shielding using the BSD...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296774/pretreatment-hematologic-markers-as-prognostic-factors-in-patients-with-nasopharyngeal-carcinoma-a-systematic-review-and-meta-analysis
#7
Li Su, Mingwei Zhang, Weijian Zhang, Chuanshu Cai, Jinsheng Hong
BACKGROUND: Pretreatment hematologic parameters of the inflammatory response, including lymphocyte, neutrophil, and platelet counts, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio, have emerged as prognostic factors for patients with cancer. This systematic review and meta-analysis aimed to summarize the association between the hematologic markers and prognosis of nasopharyngeal carcinoma (NPC). METHODS: A systematic search of PubMed, Google Scholar, MEDLINE, EMBASE, Web of Science, and the Cochrane Library was conducted up to April 2016...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28287323/relationship-between-the-comprehensive-nutritional-index-and-the-eortc-qlq-h-n35-in-nasopharyngeal-carcinoma-patients-treated-with-intensity-modulated-radiation-therapy
#8
Yan He, Liping Chen, Linmin Chen, Wen Hu, Cong Wang, Linquan Tang, Haiqiang Mai, Jianmei Li, Liping Wu, Yuying Fan
This study aimed to explore the relationship between the comprehensive nutritional index (CNI) and quality of life in nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiation therapy (IMRT). The nutritional index, which includes total lymphocyte count, hemoglobin and albumin levels, body mass index, and usual body weight percentage, was evaluated pre-treatment and post-treatment in patients who underwent IMRT. The quality of life of NPC patients was measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Cancer Module (EORTC QLQ-H&N35) at four time points: pre-treatment, post-treatment, and 3 and 6 mo after IMRT...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28278674/new-metabolites-from-the-sponge-derived-fungus-aspergillus-sydowii-j05b-7f-4
#9
Sen Liu, Haibo Wang, Mingzhi Su, Gwi Ja Hwang, Jongki Hong, Jee H Jung
Two new metabolites, diorcinolic acid (1) and β-d-glucopyranosyl aspergillusene A (8), together with six diphenylethers (2-7), a diketopiperazine (9), a chromone (10) and a xanthone (11) were isolated from the fungus Aspergillus sydowii derived from the marine sponge Stelletta sp. The planar structures and their relative configurations were elucidated by analysing 1D, 2D NMR and HRESIMS data. Compound 8 is the first glycoside of phenolic bisabolane sesquiterpenes. Compounds 1 and 8 exhibited mild cytotoxicity against KB (human nasopharyngeal carcinoma cells), HepG2 (human liver cancer cells) and HCT 116 (human colon cancer cells)...
February 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28277541/the-foxm1-abcc5-axis-contributes-to-paclitaxel-resistance-in-nasopharyngeal-carcinoma-cells
#10
Youxiang Hou, Qianling Zhu, Zheng Li, Yongbo Peng, Xiaohui Yu, Bowen Yuan, Yijun Liu, Youhong Liu, Linglong Yin, Yuchong Peng, Zhenghua Jiang, Jinping Li, Bowen Xie, Yumei Duan, Guolin Tan, Kurban Gulina, Zhicheng Gong, Lunquan Sun, Xuegong Fan, Xiong Li
Paclitaxel is clinically used as a first-line chemotherapeutic regimen for several cancer types, including head and neck cancers. However, acquired drug resistance results in the failure of therapy, metastasis and relapse. The drug efflux mediated by ATP-binding cassette (ABC) transporters and the survival signals activated by forkhead box (FOX) molecules are critical in the development of paclitaxel drug resistance. Whether FOX molecules promote paclitaxel resistance through drug efflux remains unknown. In this study, we developed several types of paclitaxel-resistant (TR) nasopharyngeal carcinoma (NPC) cells...
March 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28275034/critical-evaluation-of-the-quality-and-recommendations-of-clinical-practice-guidelines-for-nasopharyngeal-carcinoma
#11
Yu-Pei Chen, Ya-Qin Wang, Wen-Fei Li, Lei Chen, Cheng Xu, Tai-Xiang Lu, Ai-Hua Lin, Ji-Jin Yao, Yang-Chan Li, Ying Sun, Yan-Ping Mao, Jun Ma
Background: Given the distinct biological characteristics and regional distribution of nasopharyngeal carcinoma (NPC) compared with other head and neck cancers, and uncertainties regarding therapeutic strategies, physicians require high-quality clinical practice guidelines (CPGs) to provide transparent recommendations for NPC treatment. This study aimed to critically appraise the quality of NPC CPGs and assess the consistency of their recommendations. Methods: We identified CPGs that provided recommendations on the diagnosis and management of NPC published up to December 2015...
March 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28271981/understanding-epstein-barr-virus-life-cycle-with-proteomics-a-temporal-analysis-of-ubiquitination-during-virus-reactivation
#12
Dong-Wen Lv, Jun Zhong, Kun Zhang, Akhilesh Pandey, Renfeng Li
Epstein-Barr virus (EBV) is a human γ-herpesvirus associated with cancer, including Burkitt lymphoma, nasopharyngeal, and gastric carcinoma. EBV reactivation in latently infected B cells is essential for persistent infection whereby B cell receptor (BCR) activation is a physiologically relevant stimulus. Yet, a global view of BCR activation-regulated protein ubiquitination is lacking when EBV is actively replicating. We report here, for the first time, the long-term effects of IgG cross-linking-regulated protein ubiquitination and offer a basis for dissecting the cellular environment during the course of EBV lytic replication...
January 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28265567/a-study-of-358-cases-of-locally-advanced-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiation-therapy-improving-the-seventh-edition-of-the-american-joint-committee-on-cancer-t-staging-system
#13
Qin Zhou, Yuxiang He, Yajie Zhao, Yin Wang, Weilu Kuang, Liangfang Shen
To evaluate the rationality and limitations of the seventh edition of the American Joint Committee on Cancer (the 7th AJCC edition) T-staging system for locally advanced nasopharyngeal carcinoma (NPC). The prognosis of 358 patients with stage T3/T4 NPC treated with intensity-modulated radiotherapy (IMRT) was analyzed with the Kaplan-Meier method or the log-rank test. The 7th AJCC staging system of NPC has some limitations in that the T category is neither the significant factor in OS/LRFS nor the independent prognostic factor in OS/LRFS/DMFS/DFS (P > 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28265202/mir-20a-5p-promotes-radio-resistance-by-targeting-rab27b-in-nasopharyngeal-cancer-cells
#14
Dabing Huang, Geng Bian, Yueyin Pan, Xinghua Han, Yubei Sun, Yong Wang, Guodong Shen, Min Cheng, Xiang Fang, Shilian Hu
BACKGROUND: MicroRNAs (miRNAs) was reported to be involved in cancer radio-resistance, which remains a major obstacle for effective cancer therapy. METHODS: The differently expressed miRNAs were detected by RNA-seq experiment in nasopharyngeal cancer (NPC) cells. MiR-20a-5p was selected as our target, which was subject to finding its target gene Rab27B via bioinformatics analysis. The qRT-PCR, western blot and the luciferase reporter assays were performed to confirm Rab27B as the target of miR-20a-5p...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28262474/multi-institutional-randomized-trial-testing-the-utility-of-an-interactive-three-dimensional-contouring-atlas-among-radiation-oncology-residents
#15
Erin F Gillespie, Neil Panjwani, Daniel W Golden, Jillian Gunther, Tobias R Chapman, Jeffrey V Brower, Robert Kosztyla, Grant Larson, Pushpa Neppala, Vitali Moiseenko, Julie Bykowski, Parag Sanghvi, James D Murphy
PURPOSE: The delivery of safe and effective radiation therapy relies on accurate target delineation, particularly in the era of highly conformal treatment techniques. Current contouring resources are fragmented and can be cumbersome to use. The present study reports on the efficacy and usability of a web-based contouring atlas compared with those of existing contouring resources in a randomized trial. METHODS AND MATERIALS: We enrolled radiation oncology residents into a 2-phase contouring study...
December 9, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28260287/-value-of-readout-segmented-echo-planar-diffusion-imaging-on-3-0-t-mri-for-predicting-the-early-efficacy-of-concurrent-radiochemotherapy-of-advanced-stage-nasopharyngeal-carcinoma-patients
#16
C M Xu, J H Yuan, X J Chen, J R Qu, L F Wang, Y Zhao, H K Zhang, H Ge, X M Sun, X X Zhang, H L Li
Objective: To discuss the value of RESOLVE for predicting early therapeutic effect of concourrent radiochemotherapy in advanced stage nasopharngeal carcinoma patients. Methods: Sixty-eight patients with nasopharyngeal carcinoma were confirmed by pathology in Henan Cancer Hospital from June 2014 to January 2016.All patients underwent RESLOVE(b value=800 s/mm(2)) with a 3.0 T MRI scanner.The ADC value and the area of the tumor was measured before treatment and 2 weeks after treatment independently performed by two radiologists with 5 years experiences and the agreement evaluation was performed using ANOVA analysis...
February 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28260044/microrna-125b-reverses-the-multidrug-resistance-of-nasopharyngeal-carcinoma-cells-via-targeting-of-bcl-2
#17
Tai-Ze Yuan, Huan-Huan Zhang, Xiao-Ling Lin, Jin-Xiu Yu, Qiu-Xiang Yang, Yin Liang, Jin Deng, Lai-Ji Huang, Xiu-Ping Zhang
Multidrug resistance (MDR) is a major clinical obstacle in the successful treatment of patients with metastatic nasopharyngeal carcinoma (NPC). Results from previous studies suggest that microRNAs (miRNA) may be involved in promoting MDR in multiple cancer types. However, the role of miR‑125b in modulating the MDR of NPC is elusive. In the present study, miR‑125b expression in cisplatin (DDP) ‑resistant CNE2 cells (CNE2/DDP) was compared with parental counterparts, using reverse transcription‑quantitative polymerase chain reaction...
February 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259949/berberine-inhibits-the-proliferation-of-human-nasopharyngeal-carcinoma-cells-via-an-epstein-barr-virus-nuclear-antigen%C3%A2-1-dependent-mechanism
#18
Chao Wang, Huan Wang, Yaqian Zhang, Wei Guo, Cong Long, Jingchao Wang, Limei Liu, Xiaoping Sun
Nasopharyngeal carcinoma (NPC) is a malignancy derived from the epithelial cells of the nasopharynx cavity, and is closely associated with Epstein-Barr virus (EBV) infection. In addition to NPC, EBV causes various human malignancies, such as gastric cancer, hematological tumors and lymphoepithelioma-like carcinomas. Epstein-Barr nuclear antigen 1 (EBNA1) encoded by EBV is indispensable for replication, partition, transcription and maintenance of viral genomes. Berberine, a naturally occurring isoquinoline alkaloid, shows anti-inflammatory, anticholinergic, antioxidative, and anticancer activities...
March 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28256603/exome-sequencing-identifies-potentially-druggable-mutations-in-nasopharyngeal-carcinoma
#19
Yock Ping Chow, Lu Ping Tan, San Jiun Chai, Norazlin Abdul Aziz, Siew Woh Choo, Paul Vey Hong Lim, Rajadurai Pathmanathan, Noor Kaslina Mohd Kornain, Chee Lun Lum, Kin Choo Pua, Yoke Yeow Yap, Tee Yong Tan, Soo Hwang Teo, Alan Soo-Beng Khoo, Vyomesh Patel
In this study, we first performed whole exome sequencing of DNA from 10 untreated and clinically annotated fresh frozen nasopharyngeal carcinoma (NPC) biopsies and matched bloods to identify somatically mutated genes that may be amenable to targeted therapeutic strategies. We identified a total of 323 mutations which were either non-synonymous (n = 238) or synonymous (n = 85). Furthermore, our analysis revealed genes in key cancer pathways (DNA repair, cell cycle regulation, apoptosis, immune response, lipid signaling) were mutated, of which those in the lipid-signaling pathway were the most enriched...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28253718/tnfaip3-inhibits-migration-and-invasion-in-nasopharyngeal-carcinoma-by-suppressing-epithelial-mesenchymal-transition
#20
T Huang, L Yin, J Wu, J J Gu, K Ding, N Zhang, M Y Du, L X Qian, Z W Lu, X He
TNF alpha induced protein 3 (TNFAIP3), a member of zinc finger protein family, is a gene whose expression level is promptly induced by the tumor necrosis factor. In this study, the clinical significance of TNFAIP3 was analyzed based on available samples in The Cancer Genome Atlas database. TNFAIP3 downregulation was associated with distant metastasis and worse patient prognosis. TNFAIP3-overexpressing and TNFAIP3-knockdown NPC cell line models were established through plasmid-mediated overexpression and small interfering RNA (siRNA), respectively...
March 3, 2017: Neoplasma
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