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Nasopharyngeal cancer

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https://www.readbyqxmd.com/read/27904451/the-ratio-of-weight-loss-to-planning-target-volume-significantly-impacts-setup-errors-in-nasopharyngeal-cancer-patients-undergoing-helical-tomotherapy-with-daily-megavoltage-computed-tomography
#1
Wei-Hsien Hou, Chun-Wei Wang, Chiao-Ling Tsai, Feng-Ming Hsu, Jason Chia-Hsien Cheng
BACKGROUND: Changes in head and neck anatomy during radiation therapy (RT) produce setup uncertainties of nasopharyngeal cancer (NPC) irradiation. We retrospectively analyzed image guidance data to identify clinical predictors of setup errors. PATIENTS AND METHODS: The data of 217 NPC patients undergoing definitive RT on a helical tomotherapy (HT) unit were analyzed. Factors including tumor stage, body mass index, weight loss, and planning target volume (PTV) were assessed as predictors of daily megavoltage computed tomography (MVCT) setup displacements, which were automatically registered using software...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27903461/clinical-characteristics-and-outcome-of-respiratory-syncytial-virus-infection-among-adults-hospitalized-with-influenza-like-illness-in-france
#2
Paul Loubet, Nezha Lenzi, Martine Valette, Vincent Foulongne, Anne Krivine, Nadhira Houhou, Gisele Lagathu, Sylvie Rogez, Sophie Alain, Xavier Duval, Florence Galtier, Deborah Postil, Pierre Tattevin, Philippe Vanhems, Fabrice Carrat, Bruno Lina, Odile Launay
OBJECTIVES: The aim of this study was to analyze characteristics and outcome of RSV infection in adults hospitalized with influenza-like illness (ILI). METHODS: Patients hospitalized with ILI were included in this prospective, multicenter study carried out in six French hospitals during three consecutive influenza seasons (2012-2015). RSV and other respiratory viruses were detected by multiplex PCR in nasopharyngeal swabs. Risk factors for RSV infection were identified by backward stepwise logistic regression analysis...
November 26, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27902742/chloroquine-sensitizes-nasopharyngeal-carcinoma-cells-but-not-nasoepithelial-cells-to-irradiation-by-blocking-autophagy
#3
Anna Makowska, Michael Eble, Kirsten Prescher, Mareike Hoß, Udo Kontny
BACKGROUND: Treatment of nasopharyngeal carcinoma requires the application of high dosages of radiation, leading to severe long-term complications in the majority of patients. Sensitizing tumor cells to radiation could be a means to increase the therapeutic window of radiation. Nasopharyngeal carcinoma cells display alterations in autophagy and blockade of autophagy has been shown to sensitize them against chemotherapy. METHODS: We investigated the effect of chloroquine, a known inhibitor of autophagy, on sensitization against radiation-induced apoptosis in a panel of five nasopharyngeal carcinoma cell lines and a SV40-transformed nasoepithelial cell line...
2016: PloS One
https://www.readbyqxmd.com/read/27901642/a-generic-rna-pulsed-dc-based-approach-for-developing-therapeutic-intervention-against-nasopharyngeal-carcinoma
#4
Rajeev K Tyagi, Rajesh Parmar, Naisargee Patel
The recurrent nasopharyngeal carcinoma of head-and-neck cancers pathology showed unique symptoms and clinical characteristics. The complexity of pathology poses challenges for developing therapeutic interventional approaches against nasopharyngeal carcinoma (NPC). The conventional treatment regimens offer limited local control and survival, which, leads to adverse delayed complications. Our study present a generic monocyte derived dendritic cell (MoDC) vaccine strategy for NPC in which RNA is used as a source of tumor-associated antigens (TAAgs)...
November 30, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27900757/unsuspected-axillary-lymph-node-metastasis-of-nasopharyngeal-and-cervical-cancer-on-18fdg-pet-ct-a-case-report
#5
Sungmin Kang
Axillary lymph node metastasis (ALNM) from cancer except breast cancer is rare. Whole body 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) that simultaneously offers anatomic and metabolic information is widely used and has become an effective modality in many clinical fields, especially oncology, and also may detect an unexpected metastasis. We report two cases of ALMN of nasopharyngeal and cervical cancer that was detected on whole body PET/CT.
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27900042/antitumor-activity-of-7rh-a-discoidin-domain-receptor-1-inhibitor-alone-or-in-combination-with-dasatinib-exhibits-antitumor-effects-in-nasopharyngeal-carcinoma-cells
#6
Qiu-Ping Lu, Wen-Dan Chen, Jie-Ren Peng, Yao-Dong Xu, Qian Cai, Gong-Kan Feng, Ke Ding, Xiao-Feng Zhu, Zhong Guan
Dysregulation of the discoidin domain receptors (DDRs) has been implicated in the development of numerous types of tumors, including head and neck cancer, and nasopharyngeal, breast, ovarian and esophageal carcinomas. Furthermore, agents that inhibit DDR1 activity are hypothesized to be useful for the treatment of nasopharyngeal carcinoma (NPC). The aim of the present study was to evaluate the effect of the DDR1 inhibitory (3-(2-(pyrazolo(1,5-a)pyrimidin-6-yl)-ethynyl)benzamide compound, 7RH, in NPC cells both in vitro and in vivo, and its effect when used in combination with dasatinib, a SRC family kinase (SFK) inhibitor...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898198/ahns-series-do-you-know-your-guidelines-principles-of-treatment-for-nasopharyngeal-cancer-a-review-of-the-national-comprehensive-cancer-network-guidelines
#7
Zhen Gooi, Jeremy Richmon, Nishant Agrawal, Elizabeth Blair, Louis Portugal, Everett Vokes, Tanguy Seiwert, Jonas de Souza, Vassiliki Saloura, Daniel Haraf, David Goldenberg, Jason Chan
This article is a continuation of the "Do You Know Your Guidelines" series, an initiative of the American Head and Neck Society's Education Committee to increase awareness of current best practices pertaining to head and neck cancer. The National Comprehensive Cancer Network guidelines for the management of nasopharyngeal cancer are reviewed here in a systematic fashion. These guidelines outline the workup, treatment and surveillance of patients with nasopharyngeal cancer. © 2016 Wiley Periodicals, Inc. Head Neck, 2016...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27891591/nor1-suppresses-cancer-stem-like-cells-properties-of-tumor-cells-via-the-inhibition-of-the-akt-gsk-3%C3%AE-wnt-%C3%AE-catenin-aldh1a1-signal-circuit
#8
Wei Wang, Mei Yi, Shengnan Chen, Junjun Li, Haijing Zhang, Wei Xiong, Guiyuan Li, Xiaoling Li, Bo Xiang
Cancer stem cells (CSCs) play a key role in tumor radiotherapy and chemotherapy resistance, relapse, and metastasis, and are primarily maintained in a resting state in vivo. The failure of conventional therapies to target CSCs is the main cause of treatment failure. The discovery of CSCs in nasopharyngeal carcinoma (NPC) tumors is becoming more prevalent; however, the understanding of the mechanisms underlying the maintenance of tumor stemness is still limited. We previously cloned NOR1, a tumor suppressor gene downregulated in NPC cell lines and tissues...
November 27, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27887636/development-and-validation-of-a-nomogram-for-predicting-the-survival-of-patients-with-non-metastatic-nasopharyngeal-carcinoma-after-curative-treatment
#9
Wenhua Liang, Guanzhu Shen, Yaxiong Zhang, Gang Chen, Xuan Wu, Yang Li, Anchuan Li, Shiyang Kang, Xi Yuan, Xue Hou, Peiyu Huang, Yan Huang, Hongyun Zhao, Ying Tian, Chong Zhao, Li Zhang
BACKGROUND: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival (OS) of non-metastatic nasopharyngeal carcinoma (NPC) patients after curative treatments. METHODS: We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003...
November 25, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27884592/nasopharyngeal-carcinoma-with-mastoid-recurrence-after-concurrent-chemoradiotherapy-masquerading-as-acute-otomastoiditis
#10
Chih-Yu Hu, Shiang-Fu Huang, Wan-Ling Ho, Wen-Yu Chuang, Kai-Chieh Chan
Nasopharyngeal cancer (NPC) with mastoid recurrence is extraordinarily rare, and its development is thought to involve the Eustachian tube. We herein report a case of NPC with mastoid recurrence masquerading as acute otomastoiditis with facial paralysis in a 60-year-old man 44 months after concurrent chemoradiotherapy. The diagnosis was confirmed by exploratory tympanomastoidectomy with biopsy and Epstein-Barr-encoding region (EBER) in situ hybridization. Distant liver metastasis was detected simultaneously, and the patient underwent salvage treatment...
November 21, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27875901/reducing-radiation-related-morbidity-in-the-treatment-of-nasopharyngeal-carcinoma
#11
Jason W Chan, Upendra Parvathaneni, Sue S Yom
While radiation therapy is the mainstay of treatment for nasopharyngeal carcinoma, the anatomic location of the nasopharynx in close proximity to radiation-sensitive organs such as the salivary glands, optic nerves and chiasm, cochlea, brainstem and temporal lobes presents a special challenge. Technological approaches to reducing the morbidity of nasopharyngeal cancer irradiation have been historically successful with the evolution from 2D techniques to increasingly conformal forms of radiation therapy. This report reviews normal tissue dose constraints and major considerations in target delineation for patients with nasopharyngeal cancer in the intensity-modulated radiation therapy era...
November 23, 2016: Future Oncology
https://www.readbyqxmd.com/read/27864945/risk-of-nasopharyngeal-carcinoma-penetrates-across-immigrant-generations-a-migrant-cohort-study-of-2-3-million-jewish-israeli-adolescents
#12
Yakir Rottenberg, Hagai Levine, Lital Keinan-Boker, Estela Derazne, Adi Leiba, Jeremy D Kark
Nasopharyngeal cancer (NPC) incidence varies widely across geographic regions and ethnic groups. We conducted a large-scale migrant cohort study to assess origin and migrant generation as predictors of NPC, controlling for possible confounders. Data on 2.3 million Jewish Israeli adolescents, who underwent a compulsory general health examination at ages 16-19 between the years 1967-2011 were linked to the Israel National Cancer Registry to obtain incident NPC up to 2012. Cox proportional hazards was used to model time to event...
November 16, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27855392/the-emerging-roles-of-long-noncoding-rna-ror-lincrna-ror-and-its-possible-mechanisms-in-human-cancers
#13
Yan Pan, Chen Li, Jing Chen, Kai Zhang, Xiaoyuan Chu, Rui Wang, Longbang Chen
To date, there is only up to 2% of protein-coding genes that are stably transcribed, whereas the vast majority are non-coding RNAs (ncRNAs). These ncRNAs, also known as non-messenger RNAs (nmRNAs) or functional RNAs (fRNAs), include transfer RNAs, ribosomal RNAs, microRNAs and long non-coding RNAs (lncRNAs). With the advance of high-resolution microarrays and massively parallel sequencing technology, lncRNAs have gained extended attentions nowadays and are found to play important roles in tumorigenesis and progression of human cancers...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27854304/a-novel-inflammation-based-stage-i-stage-predicts-overall-survival-of-patients-with-nasopharyngeal-carcinoma
#14
Jian-Pei Li, Shu-Lin Chen, Xiao-Min Liu, Xia He, Shan Xing, Yi-Jun Liu, Yue-Hao Lin, Wan-Li Liu
Recent studies have indicated that inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified GPS (mGPS) and C-reactive protein/Albumin (CRP/Alb) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), have been reported to have prognostic value in patients with many types of cancer, including nasopharyngeal carcinoma (NPC). In this study, we proposed a novel inflammation-based stage, named I stage, for patients with NPC. A retrospective study of 409 newly-diagnosed cases of NPC was conducted...
November 15, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27852284/prognostic-value-and-predictive-threshold-of-tumor-volume-for-patients-with-locally-advanced-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiotherapy
#15
Yu-Xiang He, Ying Wang, Peng-Fei Cao, Lin Shen, Ya-Jie Zhao, Zi-Jian Zhang, Deng-Ming Chen, Tu-Bao Yang, Xin-Qiong Huang, Zhou Qin, You-Yi Dai, Liang-Fang Shen
BACKGROUND: Gross target volume of primary tumor (GTV-P) is very important for the prognosis prediction of patients with nasopharyngeal carcinoma (NPC), but it is unknown whether the same is true for locally advanced NPC patients treated with intensity-modulated radiotherapy (IMRT). This study aimed to clarify the prognostic value of tumor volume for patient with locally advanced NPC receiving IMRT and to find a suitable cut-off value of GTV-P for prognosis prediction. METHODS: Clinical data of 358 patients with locally advanced NPC who received IMRT were reviewed...
November 16, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27845040/a-human-fab-exclusively-binding-to-the-extracellular-domain-of-lmp2a
#16
Qing Cao, Dawei Zhang, Yuan Mao, Chanfang Meng, Jin Zhu, Zhenqing Feng, Renjie Chen
In the areas of North Africa, Southeast Asia as well as South China, Nasopharyngeal carcinoma (NPC) is among the most widespread cancers. Plenty of research findings confirmed that Epstein-Barr virus (EBV) played a crucial role in NPC. EBV-encoded Latent membrane protein 2A (LMP2A) which continuously expressed in cell membrane protein induced an epithelial-mesenchymal transition and increased the number of side population stem-like cancer cells in NPC. This reveals that LMP2A could contribute to the development and recurrence in NPC...
November 11, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27833652/molecular-detection-of-epstein-barr-virus-in-nasopharyngeal-carcinoma-among-sudanese-population
#17
Ali Edreis, Mona Ali Mohamed, Nouh S Mohamed, Emmanuel E Siddig
BACKGROUND: Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. NPC caused by an interaction between infection with EBV and environmental and genetic factors, encompasses a multistep oncogenic process. The frequency of Epstein-Barr virus EBV among nasopharyngeal carcinoma is well known worldwide, however, in the Sudan there is barely a published data...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27830140/failed-septal-extension-graft-in-a-patient-with-a-history-of-radiotherapy
#18
Il Gyu Kang, Seon Tae Kim, Seok Ho Lee, Min Kwan Baek
BACKGROUND: This report describes the authors' experience of "melting" septal cartilage after placement of a septal extension graft in a nasopharyngeal cancer patient that had been previously undergone radiation therapy, and provides a review of the literature. METHODS: Electronic medical records were used to obtain details of the patient's clinical history. RESULTS: A 32-year-old woman, who had previously undergone radiotherapy for nasopharyngeal cancer, visited our department to for rhinoplasty...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27828863/the-clinical-characteristics-of-secondary-primary-tumors-in-patients-with-nasopharyngeal-carcinoma-after-intensity-modulated-radiotherapy-a-retrospective-analysis
#19
Wei Zhao, Hao Lei, Xiaodong Zhu, Ling Li, Song Qu, Xia Liang, Xiao Wang
To investigate the clinical characteristics associated with the risk of developing secondary primary tumors (SPTs) in patients with nasopharyngeal carcinoma (NPC) who underwent intensity-modulated radiotherapy (IMRT).Data from 527 patients with biopsy-proven nonmetastatic NPC who were treated with IMRT between January 2007 and December 2011 were analyzed retrospectively. The cumulative incidence of SPTs after IMRT completion was estimated using the Kaplan-Meier method. Intergroup differences in the cumulative incidence were determined using the log-rank test...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27811359/sphingosine-kinase-1-is-a-potential-therapeutic-target-for-nasopharyngeal-carcinoma
#20
Wenhua Li, Jian Li, Yunchao Wang, Keqian Zhang, Ni Li, Zhiqiang Tian, Bing Ni, Huaizhi Wang, Zhihua Ruan
Sphingosine kinase 1 (SPHK1) has been shown to be involved in the progression of various types of human cancers. We previously demonstrated that SPHK1 is overexpressed and associated with clinical stage, locoregional recurrence, distant metastasis and poor prognosis in nasopharyngeal carcinoma (NPC). However, the biological roles involving SPHK1 and its potential usefulness as a therapeutic target in NPC remain unknown. In this study, Blocking SPHK1 using siRNA or FTY720 (a SPHK1 inhibitor) significantly reduced proliferation and migration and increased cell cycle arrest and apoptosis in NPC cells...
November 2, 2016: Oncotarget
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