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SLIT therapy

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https://www.readbyqxmd.com/read/29135567/benign-reactive-lymphoid-hyperplasia-of-the-conjunctiva-treated-with-cyclosporine
#1
Rupin N Parikh, Harpal S Sandhu, Giacomina Massaro-Giordano, Scott M Goldstein, Joan M OʼBrien
PURPOSE: To describe a case of reactive lymphoid hyperplasia (RLH) of the conjunctiva responding to cyclosporine immunosuppressant monotherapy. METHODS: A 66-year-old man with a 2-year history of biopsy-proven bilateral RLH presented for dry eye evaluation with chief complaints of burning, stinging, and irritation in both eyes. After slit-lamp examination and positive findings of matrix metalloproteinase 9 in the patient's tear film, he was diagnosed with meibomian gland dysfunction and tear-insufficiency dry eye disease...
November 10, 2017: Cornea
https://www.readbyqxmd.com/read/29129888/-clinical-efficacy-of-sublingual-immunotherapy-in-the-third-treated-year-with-japanese-cedar-pollinosis-in-2017
#2
Atsushi Yuta, Yukiko Ogawa, Yusuke Suzuki, Hitomi Ogihara, Nobuo Ohta, Hideaki Kozaki, Takeshi Shimizu
It past 3 years in 2017 after the first purchase of the drug for sublingual immunotherapy (SLIT) for Japanese Cedar pollinosis (JCP). We reported the clinical efficacy of SLIT in the first and the second treated year. PURPOSE: The purpose of this study is to clear the clinical efficacy of SLIT in the third treated year by comparing with other therapies, such as subcutaneous immunotherapy (SCIT), or other pharmacotherapy. METHODS: We compared the clinical efficacy in 2017, of 112 SLIT in the third treated year with 38 SCIT, 364 primary pharmacotherapy that started therapies before pollen dispersal, 254 pharmacotherapy that started therapies after pollen disposal, or 333 non-treatment...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29128229/proton-beam-therapy-for-iris-melanomas-in-107-patients
#3
Juliette Thariat, Ahmed Rahmi, Julia Salleron, Carlo Mosci, Benjamin Butet, Celia Maschi, Francesco Lanza, Sara Lanteri, Stephanie Baillif, Joel Herault, Thibaud Mathis, Jean Pierre Caujolle
PURPOSE: To report on the clinical characteristics and outcomes for patients with iris melanoma using proton therapy. DESIGN: Retrospective study. PARTICIPANTS: One hundred seven patients with iris melanoma from 3 regional ophthalmologic centers. METHODS: A retrospective study was conducted for iris melanoma patients from 3 regional ophthalmologic centers referred to and treated at a single proton therapy facility between 1996 and 2015...
November 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29113525/biological-mechanisms-underlying-the-clinical-effects-of-allergen-specific-immunotherapy-in-asthmatic-children
#4
Corrado Pelaia, Alessandro Vatrella, Nicola Lombardo, Rosa Terracciano, Paolo Navalesi, Rocco Savino, Girolamo Pelaia
Allergen-specific immunotherapy (AIT) is indicated for patients with allergic asthma and/or allergic rhinitis, and can be implemented by either subcutaneous injection (SCIT) or sublingual administration (SLIT). AIT reduces asthma symptoms, lowers the use of pharmacologic controller therapy, and decreases the need for rescue medications. SLIT appears to be safer than SCIT, but SCIT seems to be more efficacious and acts earlier in allergic asthmatic children. Areas covered: This review looks at the pathobiology of allergic asthma as well as the role of regulatory T and B cells in allergen tolerance...
November 8, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29102235/the-view-through-the-ventricle-catheter-the-new-shuntscope-for-the-therapy-of-pediatric-hydrocephalus
#5
Sebastian Senger, Sebastian Antes, Mohamed Salah, Christoph Tschan, Stefan Linsler, Joachim Oertel
PURPOSE: Correct placement of the ventricle catheter directly influences the function of cerebral shunt systems. The incidence of proximal catheter misplacement reaches up to 45%. To avoid misplacements and revisions a new intra-catheter endoscope for precise ventricle catheter placement in children was evaluated. METHODS: The semi-rigid ShuntScope (Karl Storz GmbH & Co.KG, Tuttlingen, Germany) with an outer diameter of 1.0 mm and an image resolution of 10,000 pixels was used in a series of 27 children and adolescents (18 males, 9 females, age range 2 months-18 years)...
October 25, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29094445/kidney-transplantation-in-a-child-with-pierson-syndrome
#6
Sanem Guler, Sertac Cimen, Phillip Acott, Kathy Whelan, Michele Molinari
Congenital nephrotic syndrome is commonly associated with mutations in genes that encode podocyte and slit diaphragm proteins or the structural and regulatory proteins of the GBM. These mutations lead to the formation of dysfunctional proteins, which account for the resistance of the renal manifestations to conventional treatment methods. Consequently, patients become renal replacement therapy dependent. Mutation of the LAMB2 gene is associated with Pierson syndrome, which is an autosomal recessive disorder characterized by congenital nephrotic syndrome and ocular abnormalities...
November 1, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29077180/large-choroidal-excavation-in-a-patient-with-rubella-retinopathy
#7
Maurizio Battaglia Parodi, Francesco Romano, Marco Montagna, Francesco Bandello
PURPOSE: To describe a case of rubella retinopathy complicated by bilateral choroidal neovascularization (CNV) and late development of large choroidal excavation (LCE). METHODS: A 19-year-old woman with a diagnosis of rubella retinopathy underwent her annual ophthalmologic examination, including visual acuity testing and slit-lamp biomicroscopy with dilated fundus examination. Color fundus photography, spectral-domain optical coherence tomography (SD-OCT) scans, and optical coherence tomography angiography were acquired to complete the investigation of her ocular condition...
October 17, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29022965/a-rare-presentation-of-exudative-macroaneurysms-in-unilateral-eales-disease
#8
M Nada, S Qanoongo, S V Singh, A K Khurana
BACKGROUND: A case of exudative macroaneurysms in unilateral Eales' disease is reported. 'Eales disease' is an idiopathic bilateral occlusive periphlebitis with neovascularisation and mostly presents with vitreous hemorrhage. CASE: A 30 year old male presented with diminution of vision in left eye (6/36) for 1 month. Slit Lamp examination of both eyes revealed normal anterior segment. Fundus examination of left eye with + 90 D lens revealed reddish lesions at the macula with surrounding circinate exudation...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944199/comparative-analysis-of-cytomegalovirus-retinitis-and-microvascular-retinopathy-in-patients-with-acquired-immunodeficiency-syndrome
#9
Chao Chen, Chun-Gang Guo, Li Meng, Jing Yu, Lian-Yong Xie, Hong-Wei Dong, Wen-Bin Wei
AIM: To compare the clinical manifestation of cytomegalovirus (CMV) retinitis and microvascular retinopathy (MVR) in patients with acquired immunodeficiency syndrome (AIDS) in China. METHODS: A total of 93 consecutive patients with AIDS, including 41 cases of CMV retinitis and 52 cases of MVR were retrospectively reviewed. Highly active antiretroviral therapy (HAART) status was recorded. HIV and CMV immunoassay were also tested. CD4+ T-lymphocyte count and blood CMV-DNA test were performed in all patients...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28942493/asymptomatic-corneal-keratopathy-secondary-to%C3%A2-hypertyrosinaemia-following-low-dose-nitisinone-and%C3%A2-a%C3%A2-literature-review-of-tyrosine-keratopathy-in%C3%A2-alkaptonuria
#10
M Khedr, S Judd, M C Briggs, A T Hughes, A M Milan, R M K Stewart, E A Lock, J A Gallagher, L R Ranganath
Nitisinone, although unapproved for use in alkaptonuria (AKU), is currently the only homogentisic acid lowering therapy with a potential to modify disease progression in AKU. Therefore, safe use of nitisinone off-label requires identifying and managing tyrosine keratopathy. A 22-year-old male with AKU commenced 2 mg daily nitisinone after full assessment. He was issued an alert card explaining potential ocular symptoms such as red eye, tearing, ocular pain and visual impairment and how to manage them. On his first and second annual follow-up visits to the National Alkaptonuria Centre (NAC), there was no corneal keratopathy on slit lamp examination...
September 24, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28940458/eaaci-guidelines-on-allergen-immunotherapy-allergic-rhinoconjunctivitis
#11
G Roberts, O Pfaar, C A Akdis, I J Ansotegui, S R Durham, R Gerth van Wijk, S Halken, D Larenas-Linnemann, R Pawankar, C Pitsios, A Sheikh, M Worm, S Arasi, M A Calderon, C Cingi, S Dhami, J L Fauquert, E Hamelmann, P Hellings, L Jacobsen, E F Knol, S Y Lin, P Maggina, R Mösges, J N G Oude Elberink, G B Pajno, E A Pastorello, M Penagos, G Rotiroti, C B Schmidt-Weber, F Timmermans, O Tsilochristou, E-M Varga, J N Wilkinson, A Williams, L Zhang, I Agache, E Angier, M Fernandez-Rivas, M Jutel, S Lau, R van Ree, D Ryan, G J Sturm, A Muraro
Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease-modifying effect...
September 23, 2017: Allergy
https://www.readbyqxmd.com/read/28926886/-keratectomy-combined-with-intrastromal-injection-of-voriconazole-in-treating-fungal-keratitis
#12
S X Li, J Biang, X Li, L T Zhang, W Y Shi
Objective: To investigate the treatment effect of keratectomy combined with intrastromal injection of voriconazole on fungal keratitis. Methods: Retrospective study. Ninety-eight fungal keratitis patients (98 eyes) were treated by keratectomy combined with intrastromal injection of voriconazole in Shandong Eye Hospital from January 2013 to May 2015. The corneal ulcers were mostly located in the paracentral or peripheral cornea, which incompletely blocked the pupil area. Slit lamp and anterior segment optical coherence tomography (AS-OCT) were used for lesion detection...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926885/-evaluation-of-short-term-effect-of-intense-pulsed-light-combined-with-meibomian-gland-expression-in-the-treatment-of-meibomian-gland-dysfunction
#13
B Rong, P Tu, Y Tang, R X Liu, W J Song, X M Yan
Objective: To explore short-term effect of intense pulsed light (IPL) combined with meibomian gland expression in treating meibomian gland dysfunction (MGD). Methods: This study was a prospective, randomized, double-masked, controlled study. Forty-four MGD patients were enrolled in the study and received three consecutive IPL treatments with an interval of 4 weeks. One eye of each patient was randomly assigned as the study eye receiving the IPL therapy with an energy of 14-16 J/cm(2), and the fellow eye was as the control eye receiving a placebo therapy with 0 J/cm(2)...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28910175/neurotrophic-keratopathy-therapeutic-approach-using-a-novel-matrix-regenerating-agent
#14
Marta Guerra, Sara Marques, João Quadrado Gil, Joana Campos, Paula Ramos, Andreia Martins Rosa, Maria João Quadrado, Joaquim Neto Murta
PURPOSE: To evaluate the efficacy and tolerance of a new matrix-regenerating agent (RGTA), Cacicol(®), a polymer that mimics heparan sulfates bound to extracellular matrix proteins, avoiding its proteolysis, to treat neurotrophic keratopathy (NK). METHODS: Uncontrolled prospective clinical study performed between January 2014 and May 2016. Twenty-five patients (25 eyes) with corneal neurotrophic ulcers, nonresponsive to at least 2 weeks of conservative therapy, were treated with Cacicol, instilled once/twice a week...
November 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28898538/longitudinal-slit-procedure-combined-with-negative-pressure-wound-therapy-for-exposed-achilles-tendons
#15
Tino Wetzig, Diana Kohn
No abstract text is available yet for this article.
September 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28859707/quality-of-life-outcomes-in-patients-who-underwent-subcutaneous-immunotherapy-and-sublingual-immunotherapy-in-a-real-world-clinical-setting
#16
Theresa Schwanke, Eugene Carragee, Maria Bremberg, William R Reisacher
OBJECTIVE: To compare changes in quality of life (QOL) that resulted from sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) in a real-world clinical setting. BACKGROUND: SLIT is established as a viable alternative to SCIT for the treatment of allergic rhinitis. Although comparative trials are increasingly available, few studies have examined QOL outcomes between these two treatments. METHODS: One hundred and five participants who underwent immunotherapy for airborne allergies were enrolled in this prospective, single-center study...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28858960/ahmed-valve-upstream-obstruction-caused-by-fibrous-ingrowth-surgical-approach
#17
Joana Medeiros Pinto, Nuno Pinto Ferreira, Luis Abegão Pinto
Glaucoma secondary to penetrating keratoplasty can be challenging and multiple surgeries may be needed to control the intraocular pressure (IOP), including the use of glaucoma drainage implants. However, late failure of these drainage implant surgery is common, mostly because of excessive scarring or bleb encapsulation which may require further surgical intervention. We present a case of a young patient referred for advanced glaucoma secondary to penetrating keratoplasty and chronic uveitis. He presented with elevated IOP under maximal therapy, already with 2 failed trabeculectomies and a nonfunctional Ahmed Valve...
October 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28852936/down-regulation-of-pax2-promotes-in-vitro-differentiation-of-podocytes-from-human-cd34-cells
#18
Manne Mudhu Sunitha, Lokanathan Srikanth, Pasupuleti Santhosh Kumar, Chodimella Chandrasekhar, Potukuchi Venkata Gurunadha Krishna Sarma
Podocytes are major kidney cells that help in glomerular filtration and any damage or loss is a major event in the progression of kidney diseases. Understanding podocytes development will help in designing therapeutic strategies against these renal diseases. Therefore, in vitro generation of podocytes from adult hematopoietic CD34(+) stem cells is explored in the present study. Apheretically, isolated human HSCs from peripheral blood showed the presence of CD34 surface glycoprotein through immunocytochemistry (ICC) and flowcytometry...
August 29, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28852159/loss-of-the-podocyte-glucocorticoid-receptor-exacerbates-proteinuria-after-injury
#19
Han Zhou, Xuefei Tian, Alda Tufro, Gilbert Moeckel, Shuta Ishibe, Julie Goodwin
Nephrotic syndrome is a common disorder in adults and children whose etiology is largely unknown. Glucocorticoids remain the mainstay of therapy in most cases, though their mechanism of action remains poorly understood. Emerging evidence suggests that immunomodulatory therapies used in nephrotic syndrome directly target the podocytes. To study how steroids directly affect the podocytes in the treatment of proteinuria, we created a mouse model with podocyte-specific deletion of the glucocorticoid receptor. The podocyte-specific glucocorticoid receptor (GR) knockout mice had similar renal function and protein excretion compared to wild type...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846472/the-current-state-of-food-allergy-therapeutics
#20
Meng Chen, Michael Land
The prevalence of IgE mediated food allergy is an increasing public health concern. The current standard of treatment is strict avoidance of the offending food(s). There are no FDA approved treatments for food allergy. This review will provide an overview of strategies currently under investigation for the treatment of food allergy. The main focus of research has been directed at various forms of immunotherapy, including oral, sublingual and epicutaneous delivery routes. While oral immunotherapy (OIT) has shown the greatest promise for efficacy in terms of amount of protein that can be ingested, it has also demonstrated less tolerability and a less favorable safety profile as compared to sublingual immunotherapy (SLIT) and epicutaneous immunotherapy (EPIT), which offers the least protection but has the best safety and tolerability profile...
October 3, 2017: Human Vaccines & Immunotherapeutics
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