keyword
MENU ▼
Read by QxMD icon Read
search

SLIT therapy

keyword
https://www.readbyqxmd.com/read/28500230/conjunctival-lymphangiectasia-associated-with-classic-fabry-disease
#1
Melanie D Sivley, Eric L Wallace, David G Warnock, William J Benjamin
BACKGROUND: Fabry disease (FD) is a treatable multisystem disease caused by a defect in the alpha-galactosidase gene. Ocular signs of FD, including corneal verticillata, are among the earliest diagnostic findings. Conjunctival lymphangiectasia (CL) has not previously been associated with FD. METHODS: We examined the eyes of a cohort of 13 adult patients, eight men and five women, with documented classic FD, all treated with enzyme replacement therapy (ERT) at the University of Alabama at Birmingham between February 2014 and April 2015...
May 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28489722/bilateral-herpetic-keratitis-after-bilateral-intravitreal-bevacizumab-for-exudative-macular-degeneration
#2
Angeline M Derham, Eric Chen, Vatinee Y Bunya, Ronan E OʼMalley
PURPOSE: To report a case of bilateral herpetic epithelial keratitis after bilateral intravitreal bevacizumab injections for the treatment of exudative age-related macular degeneration. METHODS: A 66-year-old man with diabetes and an extensive history of bilateral anti-vascular endothelial growth factor treatments for exudative age-related macular degeneration received an intravitreal bevacizumab injection in the right eye and triple therapy (bevacizumab, photodynamic therapy, and triamcinolone acetonide) in the left eye...
May 9, 2017: Cornea
https://www.readbyqxmd.com/read/28486314/cellular-therapy-with-human-autologous-adipose-derived-adult-stem-cells-for-advanced-keratoconus
#3
Jorge L Alió Del Barrio, Mona El Zarif, María P de Miguel, Albert Azaar, Norman Makdissy, Walid Harb, Ibrahim El Achkar, Francisco Arnalich, Jorge L Alió
PURPOSE: The aim of this phase 1 study was to preliminarily evaluate the safety and efficacy of autologous adipose-derived adult stem cell (ADASC) implantation within the corneal stroma of patients with advanced keratoconus. METHODS: Five consecutive patients were selected. Autologous ADASCs were obtained by elective liposuction. ADASCs (3 × 10) contained in 1 mL saline were injected into the corneal stroma through a femtosecond-assisted 9.5-mm diameter lamellar pocket under topical anesthesia...
May 8, 2017: Cornea
https://www.readbyqxmd.com/read/28484690/subcutaneous-and-sublingual-immunotherapy-in-allergic-asthma-in-children
#4
REVIEW
Sophia Tsabouri, Antigoni Mavroudi, Gavriela Feketea, George V Guibas
This review presents up-to-date understanding of immunotherapy in the treatment of children with allergic asthma. The principal types of allergen immunotherapy (AIT) are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Both of them are indicated for patients with allergic rhinitis and/or asthma, who have evidence of clinically relevant allergen-specific IgE, and significant symptoms despite reasonable avoidance measures and/or maximal medical therapy. Studies have shown a significant decrease in asthma symptom scores and in the use of rescue medication, and a preventive effect on asthma onset...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28477325/clinical-practice-a-proposed-standardized-ophthalmological-assessment-for-patients-with-cystinosis
#5
REVIEW
Anne-Marie Pinxten, Minh-Tri Hua, Jennifer Simpson, Katharina Hohenfellner, Elena Levtchenko, Ingele Casteels
Cystinosis is a rare autosomal recessive disease with an incidence of approximately 1 case per 100,000-200,000 live births. Over the years, gaining in-depth knowledge of the disease has led to vast improvement in patient life expectancy. However, debilitating, extra-renal manifestations such as eye disease, in particular corneal crystal deposition and its associated photophobia, still occur frequently, regardless of patient age and notwithstanding the increased implementation of systemic therapy. Ophthalmological assessment has not yet been standardized...
May 5, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28429128/endophthalmitis-associated-with-purpureocillium-lilacinum-during-infliximab-treatment-for-surgically-induced-necrotizing-scleritis-successfully-treated-with-27-gauge-vitrectomy
#6
Masaaki Yoshida, Shunji Yokokura, Hiroshi Kunikata, Naoko Takada, Kazuichi Maruyama, Masahiro Toyokawa, Kazushi Kashio, Mitsuo Kaku, Toru Nakazawa
PURPOSE: To report a case of endophthalmitis associated with Purpureocillium lilacinum (P. lilacinum) during infliximab treatment for surgically induced necrotizing scleritis, successfully treated with 27-gauge vitrectomy. METHODS: A single case report. RESULTS: A 71-year-old man who had undergone immunosuppressive therapy, including infliximab, for surgically induced necrotizing scleritis (SINS) in his left eye complained of visual disturbance and eye pain in the eye...
April 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28406573/brief-report-robo1-regulates-the-migration-of-human-subventricular-zone-neural-progenitor-cells-during-development
#7
Hugo Guerrero-Cazares, Emily Lavell, Linda Chen, Paula Schiapparelli, Montserrat Lara-Velazquez, Vivian Capilla-Gonzalez, Anna Christina Clements, Gabrielle Drummond, Liron Noiman, Katrina Thaler, Anne Burke, Alfredo Quiñones-Hinojosa
Human neural progenitor cell (NPC) migration within the subventricular zone (SVZ) of the lateral ganglionic eminence is an active process throughout early brain development. The migration of human NPCs from the SVZ to the olfactory bulb during fetal stages resembles what occurs in adult rodents. As the human brain develops during infancy, this migratory stream is drastically reduced in cell number and becomes barely evident in adults. The mechanisms regulating human NPC migration are unknown. The Slit-Robo signaling pathway has been defined as a chemorepulsive cue involved in axon guidance and neuroblast migration in rodents...
April 13, 2017: Stem Cells
https://www.readbyqxmd.com/read/28371482/additive-effects-and-safety-of-fixed-combination-therapy-with-1-brinzolamide-and-0-5-timolol-versus-1-dorzolamide-and-0-5-timolol-in-prostaglandin-treated-glaucoma-patients
#8
Makoto Aihara, Misato Adachi, Hiroshi Matsuo, Tetsuya Togano, Takeo Fukuchi, Noriyuki Sasaki
PURPOSE: To compare the additive effects and safety of 1% brinzolamide/0.5% timolol fixed combination (BTFC) versus the low-dose regimen of 1% dorzolamide/0.5% timolol fixed combination (DTFC) in patients with open-angle glaucoma and ocular hypertension (OAG/OH) following treatment with prostaglandin analogues (PGAs). METHODS: A prospective, randomized, double-masked, multicentre, parallel-group and active-controlled study included 201 Japanese OAG/OH patients who had been treated with PGA...
April 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28360084/the-revitalisation-of-flexor-tendon-allografts-with-bone-marrow-stromal-cells-and-mechanical-stimulation-an-ex-vivo-model-revitalising-flexor-tendon-allografts
#9
J H Wu, A R Thoreson, A Gingery, K N An, S L Moran, P C Amadio, C Zhao
OBJECTIVES: The present study describes a novel technique for revitalising allogenic intrasynovial tendons by combining cell-based therapy and mechanical stimulation in an ex vivo canine model. METHODS: Specifically, canine flexor digitorum profundus tendons were used for this study and were divided into the following groups: (1) untreated, unprocessed normal tendon; (2) decellularised tendon; (3) bone marrow stromal cell (BMSC)-seeded tendon; and (4) BMSC-seeded and cyclically stretched tendon...
March 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28358746/solitary-retinal-capillary-hemangioma-in-a-patient-with-bilateral-chorioretinal-coloboma
#10
Andres F Lasave, Pablo Deromedis
PURPOSE: To report a case showing a very rare association of chorioretinal coloboma and retinal capillary hemangioma in a previously healthy patient. METHODS: Observational case report. RESULTS: A 21-year-old woman presented at our clinic for vision screening. She had a history of bilateral chorioretinal coloboma with amblyopia in her left eye. Her best-corrected visual acuity was 20/25 in her right eye and 20/200 in her left eye. On slit-lamp examination, iris coloboma was observed in the left eye...
March 29, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28341297/geant4-models-for-the-secondary-radiation-flux-in-the-collimation-system-of-a-300mev-proton-microbeam
#11
Yanxin Dou, David N Jamieson, Jianli Liu, Anlong Li, Liyi Li
In Harbin, we are developing a 300MeV proton microbeam for many applications in space science including upset studies in microelectronic devices, radiation hardness of materials for satellites and radiation effects in human tissues. There are also applications of this facility proposed for proton therapy. The microbeam system will employ a purpose-built proton synchrotron to provide the beam. However there are many challenges to be addressed in the design, construction and operation of this facility. Here we address two important design aspects for which we apply GEANT4 modeling...
December 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28326906/a-practical-guide-to-the-sublingual-immunotherapy-tablet-adverse-event-profile-implications-for-clinical-practice
#12
David I Bernstein, Jose A Bardelas, Bodil Svanholm Fogh, Amarjot Kaur, Ziliang Li, Hendrik Nolte
OBJECTIVES: Treatment with allergy immunotherapy improves allergic rhinoconjunctivitis, but can also improve comorbidities associated with allergic rhinitis such as asthma. Sublingual immunotherapy (SLIT)-tablets are a convenient and efficacious method of allergy immunotherapy. They are self-administered after the first tablet has been provided under medical supervision. Therapy may elicit local reactions or, rarely, systemic allergic reactions. The objective of this report is to inform healthcare practitioners about the safety and tolerability profile of SLIT-tablets and use this information to provide practical guidance that may inform patients regarding potential adverse reactions and how to manage them...
March 22, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28318634/dna-methyltransferase-1-may-be-a-therapy-target-for-attenuating-diabetic-nephropathy-and-podocyte-injury
#13
Li Zhang, Qianmei Zhang, Shuangxin Liu, Yuanhan Chen, Ruizhao Li, Ting Lin, Chunping Yu, Hong Zhang, Zhongshun Huang, Xinchen Zhao, Xiaofan Tan, Zhuo Li, Zhiming Ye, Jianchao Ma, Bin Zhang, Wenjian Wang, Wei Shi, Xinling Liang
The contribution of DNA methylation to diabetic nephropathy, especially the effect on podocyte integrity, is not clarified. Here we found that albuminuria in a db/db mouse model was markedly attenuated after treatment with a DNA methylation inhibitor. This was accompanied by alleviation of glomerular hypertrophy, mesangial matrix expansion, and podocyte injury. The expression of DNA methyltransferase 1 (Dnmt1), nuclear factor Sp1, and nuclear factor kappa B (NFκB)-p65 markedly increased in podocytes in vivo and in vitro under the diabetic state...
March 15, 2017: Kidney International
https://www.readbyqxmd.com/read/28299008/intravitreal-injection-of-bone-marrow-mesenchymal-stem-cells-in-patients-with-advanced-retinitis-pigmentosa-a-safety-study
#14
Leila Satarian, Ramin Nourinia, Sare Safi, Mozhgan Rezaei Kanavi, Neda Jarughi, Narsis Daftarian, Leila Arab, Nasser Aghdami, Hamid Ahmadieh, Hossein Baharvand
PURPOSE: To examine the safety of a single intravitreal injection of autologous bone Marrow Mesenchymal stem cells (MSCs) in patients with advanced retinitis pigmentosa (RP). METHODS: A prospective, phase I, nonrandomized, open-label study was conducted on 3 eyes of 3 volunteers with advanced RP. Visual acuity, slit-lamp examination, fundus examination, optical coherence tomography, fundus auto-fluorescence, fluorescein angiography and multifocal electroretinography were performed before and after an intravitreal injection of approximately one-million MSCs...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28275599/ocular-surface-squamous-neoplasia-associated-with-atopic-keratoconjunctivitis
#15
Ankit Shah, Edgar M Espana, Arun D Singh
PURPOSE: To describe 2 cases of invasive squamous cell carcinoma that originated in the setting of severe atopic keratoconjunctivitis (AKC). METHODS: Case one involved a 73-year-old male with atopic eczema and severe AKC who developed a limbal lesion suspicious for ocular surface squamous neoplasia (OSSN). Slit-lamp examination was significant for a new sessile lesion in the temporal limbal region of the left eye. The lesion was treated with excisional biopsy and cryotherapy...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28261507/endoscopic-appearance-of-oropharyngeal-and-upper-gi-kaposi-s-sarcoma-in-an-immunocompromised-patient
#16
Umar Darr, Anas Renno, Zubair Khan, Turki Alkully, Maitham A Moslim, Sehrish Kamal, Ali Nawras
Introduction. Kaposi's sarcoma (KS) usually manifests as a cutaneous disease but GI manifestation is often rare. It is associated with human herpes virus-8 (HHV-8) and seen in immunocompromised patients. In the USA, use of highly active antiretroviral therapy (HAART) has drastically reduced incidence of KS in HIV patients. Case Presentation. A 65-year-old male with human immunodeficiency virus (HIV) was admitted to the intensive care unit (ICU) with cardiopulmonary arrest secondary to hyperkalemia of 7.5 meq/L...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28228933/vascularization-and-innervation-of-slits-within-polydimethylsiloxane-sheets-in-the-subcutaneous-space-of-athymic-nude-mice
#17
Rachel E Gurlin, Mark T Keating, Shiri Li, Jonathan Rt Lakey, Sébastien de Feraudy, Bhupinder S Shergill, Elliot L Botvinick
Success of cell therapy in avascular sites will depend on providing sufficient blood supply to transplanted tissues. A popular strategy of providing blood supply is to embed cells within a functionalized hydrogel implanted within the host to stimulate neovascularization. However, hydrogel systems are not always amenable for removal post-transplantation; thus, it may be advantageous to implant a device that contains cells while also providing access to the circulation so retrieval is possible. Here we investigate one instance of providing access to a vessel network, a thin sheet with through-cut slits, and determine if it can be vascularized from autologous materials...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28207431/successful-medical-management-of-presumptive-pythium-insidiosum-keratitis
#18
Muralidhar Ramappa, Ritu Nagpal, Savitri Sharma, Sunita Chaurasia
PURPOSE: To describe the previously unreported successful treatment of presumptive Pythium keratitis (PK) with medical therapy alone. METHODS: A 42-year-old female homemaker presented to us with a 15-day history of pain and redness in the right eye after a trivial injury. Her vision was 20/80 at presentation. Slit-lamp biomicroscopy revealed a central, dense and dry-looking, grayish-white infiltrate reaching mid stroma. The infiltrate had feathery margins and was surrounded by multiple tentacle-like lesions and peripherally expanding pinhead-sized subepithelial lesions...
February 15, 2017: Cornea
https://www.readbyqxmd.com/read/28182329/perceived-compliance-and-barriers-to-care-in-sublingual-immunotherapy
#19
Manvinder S Kumar, Melissa S Oh, Brittany Leader, Melissa Rotella, Leisa Stillman, John M DelGaudio, Sarah K Wise
BACKGROUND: For allergy immunotherapy to be effective, patient compliance is critical. However, aqueous sublingual immunotherapy (SLIT) may be considered demanding for patients, requiring strict daily dosing and refilling of medication at regular intervals. In this study we sought to determine how patients perceive their own compliance with SLIT and identify barriers that may hinder compliance. METHODS: Using a retrospective review, 46 patients currently undergoing aqueous SLIT were identified to have less-than-excellent compliance based on frequency of clinic visits for SLIT refills...
May 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28141955/investigational-new-drugs-for-allergic-rhinitis
#20
REVIEW
Peter A Ricketti, Sultan Alandijani, Chen Hsing Lin, Thomas B Casale
Allergic rhinitis (AR) is a multifactorial disease characterized by paroxysmal symptoms of sneezing, rhinorrhea, postnasal drip and nasal congestion. For over a century, subcutaneous allergen immunotherapy (SCIT) has been recognized as the most effective therapy to date that may modify the underlying disease course and provide long-term benefits for individuals refractory to pharmacotherapy. However, over the past 25 years, there has been substantial growth in developing alternative therapies to traditional SCIT...
March 2017: Expert Opinion on Investigational Drugs
keyword
keyword
27615
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"