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https://www.readbyqxmd.com/read/29656306/oral-and-sublingual-immunotherapy-for-treatment-of-ige-mediated-food-allergy
#1
REVIEW
Amy M Scurlock
Development of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary allergens. Oral immunotherapy (OIT) has demonstrated efficacy in promoting immunomodulatory effects that lead to the clinical outcome of desensitization, defined as reduced reactivity while on active OIT, in the majority of treated individuals; however, achievement of sustained unresponsiveness following cessation of therapy has been observed in a smaller subset of treated subjects...
April 14, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29622703/immune-stromal-keratitis-a-rare-ocular-presentation-of-tuberculosis
#2
Deepali Singhal, Prafulla Kumar Maharana, Namrata Sharma, Jeewan S Titiyal
An 11-year-old female patient presented with diminution of vision in both the eyes for the last 4 days. She had redness, watering and photophobia for the past 11 days. Slit lamp examination revealed multiple disc-shaped corneal stromal infiltrates with an overlying epithelial defect and hypopyon in both the eyes. A provisional diagnosis of infective keratitis was made. The patient was started on empirical antimicrobial therapy. However, no improvement was noted over the next 72 hours. Microbiological examination of the corneal scraping from both the eyes was negative...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29610174/recalcitrant-atopic-keratoconjunctivitis-in-children-a-case-report-and-literature-review
#3
Jing Li, Xiaohui Luo, Hongmin Ke, Lingyi Liang
Atopic keratoconjunctivitis (AKC) is the most severe type of allergic conjunctivitis and may eventually lead to blindness. Although AKC is reported to be more prevalent in adults, we report a child with AKC whose clinical characteristics were not inconsistent with those typically seen in adult patients with AKC, and who was refractory to traditional topical anti-inflammatory and immunosuppressant therapies. An 11-year-old boy presented with a 3-month history of ocular redness and itching and decreased vision for a week in both eyes...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29594119/monogenic-causes-of-proteinuria-in-children
#4
REVIEW
Onur Cil, Farzana Perwad
Glomerular disease is a common cause for proteinuria and chronic kidney disease leading to end-stage renal disease requiring dialysis or kidney transplantation in children. Nephrotic syndrome in children is diagnosed by the presence of a triad of proteinuria, hypoalbuminemia, and edema. Minimal change disease is the most common histopathological finding in children and adolescents with nephrotic syndrome. Focal segmental sclerosis is also found in children and is the most common pathological finding in patients with monogenic causes of nephrotic syndrome...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29564417/fungal-keratitis-caused-by-rare-organisms
#5
Seyed Ali Tabatabaei, Mehdi Tabatabaei, Mohammad Soleimani, Zahra Fallah Tafti
Purpose: To report two rare cases of filamentous fungal keratitis. Methods: Two non-consecutive patients presented with suspicious fungal keratitis. After performing the smear and culture, medical therapy was started for them. They underwent slit photography and in vivo confocal microscopy (IVCM) in their follow-up visits. Results: The patients were 33-year-old and 56-year-old farmer men. They both mentioned a history of ocular trauma by plants...
March 2018: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/29548928/successful-single-treatment-with-ziv-aflibercept-for-existing-corneal-neovascularization-following-ocular-chemical-insult-in-the-rabbit-model
#6
Gore Ariel, Horwitz Vered, Cohen Maayan, Gutman Hila, Cohen Liat, Gez Relli, Kadar Tamar, Dachir Shlomit
PURPOSE: To evaluate the efficacy of ziv-aflibercept as a treatment for established corneal neovascularization (NV) and to compare its efficacy to that of bevacizumab following ocular chemical insult of sulfur mustard (SM) in the rabbit model. METHODS: Chemical SM burn was induced in the right eye of NZW rabbits by vapor exposure. Ziv-aflibercept (2 mg) was applied once to neovascularized eyes by subconjunctival injection while subconjunctival bevacizumab (5 mg) was administered twice a week, for 3 weeks...
March 13, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29545426/coinfection-of-leprosy-and-tuberculosis
#7
Seema Shetty, Shashikiran Umakanth, Bhawani Manandhar, Pankaj Bahadur Nepali
Leprosy and tuberculosis (TB) are endemic to India, however, their coinfection is not frequently encountered in clinical practice. Here, we report a 32-year-old female patient who presented with a history of high-grade intermittent fever, cough and painless skin lesions since a month, along with bilateral claw hand (on examination). The haematological profile was suggestive of anaemia of chronic disease, chest radiograph showed consolidation, sputum smears were positive for Mycobacterium tuberculosis, and skin slit smear confirmed leprosy...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29527025/clinical-and-histopathological-response-to-multidrug-therapy-in-paucibacillary-leprosy-at-the-end-of-6-months-a-prospective-observational-study-from-eastern-india
#8
Indrashis Podder, Abanti Saha, Debabrata Bandyopadhyay
Background: At present, the WHO recommends fixed duration multidrug therapy (FD-MDT) for the treatment of leprosy, in which treatment is provided for a fixed duration regardless of clearance of skin lesions or bacterial status of the patient. There is divided opinion regarding the efficacy of FD-MDT; especially for paucibacillary Hansen's disease, in which treatment is provided for 6 months. In addition, there is a paucity of literature on clinical and histopathological features of treated leprosy...
January 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29504950/opening-windows-for-bone-remodeling-through-a-slit
#9
Jameel Iqbal, Tony Yuen, Se-Min Kim, Mone Zaidi
Bone formation and resorption are tightly coupled, and dysfunction of either process leads to bone diseases, such as osteoporosis. Bone-forming agents have been explored clinically to increase bone density; however, long-term efficacy of these strategies is limited due to the accompanying increase in resorption in response to increased bone formation. Axonal guidance molecules have recently been shown to regulate formation-resorption coupling and thus have the potential for osteoporosis therapy. In this issue of the JCI, Kim et al...
March 5, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29490341/novel-combination-bmp7-and-hgf-gene-therapy-instigates-selective-myofibroblast-apoptosis-and-reduces-corneal-haze-in-vivo
#10
Suneel Gupta, Michael K Fink, Arkasubhra Ghosh, Ratnakar Tripathi, Prashant R Sinha, Ajay Sharma, Nathan P Hesemann, Shyam S Chaurasia, Elizabeth A Giuliano, Rajiv R Mohan
Purpose: We tested the potential of bone morphogenic protein 7 (BMP7) and hepatocyte growth factor (HGF) combination gene therapy to treat preformed corneal fibrosis using established rabbit in vivo and human in vitro models. Methods: Eighteen New Zealand White rabbits were used. Corneal fibrosis was produced by alkali injury. Twenty-four hours after scar formation, cornea received topically either balanced salt solution (BSS; n = 6), polyethylenimine-conjugated gold nanoparticle (PEI2-GNP)-naked plasmid (n = 6) or PEI2-GNP plasmids expressing BMP7 and HGF genes (n = 6)...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29470971/use-of-autologous-serum-tears-for-the-treatment-of-ocular-surface-disease-from-patients-with-systemic-autoimmune-diseases
#11
Tayyeba K Ali, Allister Gibbons, Cristián Cartes, Siamak Zarei-Ghanavati, Mohamed Gomaa, Ingrid Gonzalez, Astrid E Gonzalez, Hilal E Ozturk, Carolina Betancurt, Victor L Perez
PURPOSE: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s). DESIGN: Retrospective, interventional case series. METHODS: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20-50%) for chronic surface disease were analyzed. Standardized measures of subjective dry eye symptoms, objective dry eye staining of the cornea, and slit lamp findings including punctate epithelial erosion (PEE), filamentary keratopathy (FK) and corneal epithelial defects (KED) were compared during first and last visit...
February 19, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29470658/current-status-of-potential-therapies-for-ige-mediated-food-allergy
#12
REVIEW
Christopher P Parrish, Daniel Har, J Andrew Bird
PURPOSE OF REVIEW: The goal of this review is to provide the reader with an updated summary of published trial data regarding the use of oral immunotherapy (OIT), sublingual immunotherapy (SLIT), and epicutaneous immunotherapy (EPIT) for treatment of IgE-mediated food allergies. RECENT FINDINGS: Data from phase 2 trials for treatment of peanut allergy with OIT and EPIT reveal an increase in the threshold of reactivity for peanut-allergic children. Compared to EPIT, OIT promotes a greater increase in the threshold of reactivity; however, adverse events are more common with OIT...
February 22, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29449025/-prospective-monocentric-uncontrolled-study-of-efficacy-tolerance-and-adherence-of-cyclosporin-0-1-for-severe-dry-eye-syndrome
#13
Y Boujnah, R Mouchel, H El-Chehab, C Dot, C Burillon, V Kocaba
PURPOSE: To evaluate the efficacy, tolerability and treatment adherence of Ikervis ® (Santen, SAS) (ciclosporine 0.1 %) for first line therapy or following treatment with Restasis ® (Allergan, Inc.) (ciclosporine 0.05 %) for severe dry eye syndrome. MATERIAL AND METHODS: A prospective, monocentric, uncontrolled study was conducted between January 2012 and March 2015 on 110 eyes of 55 patients with severe dry eye on first line therapy or previously treated with Restasis ® who required the introduction of Ikervis ® ...
February 12, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29440137/basilar-artery-fenestration-an-unusual-possible-cause-of-ischaemic-stroke
#14
Xuan Wu, Aiyu Lin, Jiting Zhu, Bin Cai
Basilar artery fenestration is an uncommon congenital dysplasia and may be associated with ischaemic stroke. We present a case of a previously healthy 36-year-old man who presented with vertigo and vomiting. MRI showed posterior circulation territory infarction. High-resolution magnetic resonance angiography revealed a slit-like fenestration in the basilar artery. This patient had no traditional vascular risk factors or aetiology of cryptogenic stroke. The patient recovered from his neurological deficit after antiplatelet therapy and was given prophylactic aspirin therapy...
February 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29434271/adherence-and-quality-of-life-in-adults-and-children-during-3-years-of-slit-treatment-with-grazax-a-real-life-study
#15
Hampus Kiotseridis, Peter Arvidsson, Vibeke Backer, Vagn Braendholt, Alf Tunsäter
Respiratory allergic disease represents a global health problem, 30% of the population suffers from allergic rhinoconjunctivitis and 20% suffer from asthma. Allergy immunotherapy induce immunological tolerance and thereby modify the response to allergens and sublingual immunotherapy (SLIT) offers the possibility of home administration of allergen therapy, but adherence is more uncertain. The aim of the study was to investigate the adherence with GRAZAX in adults and children ≥ 5 years during three consecutive years of treatment...
February 12, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29432967/lack-of-effect-of-grastek%C3%A2-on-birch-pollen-induced-allergic-rhinoconjunctivitis-in-the-environmental-exposure-unit
#16
Anne K Ellis, Mark W Tenn, Lisa M Steacy, Daniel E Adams, Andrew G Day, Terry J Walker, Hendrik Nolte
BACKGROUND: Grastek® is a standardized sublingual immunotherapy tablet(SLIT-T) approved for the treatment of grass pollen-induced allergic rhinitis(AR) and conjunctivitis. Many grass-allergic patients are also co-sensitized to birch pollen. Whether Grastek® can confer symptomatic benefits for birch pollen-induced AR symptoms is unknown. OBJECTIVE: To evaluate the treatment effect of Grastek® for birch pollen-induced AR in participants sensitized to both grass and birch pollen using the Environmental Exposure Unit(EEU)...
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29429293/-deep-anterior-lamellar-keratoplasty-combined-with-antiviral-therapy-in-the-treatment-of-severe-herpes-necrotizing-stromal-keratitis
#17
S X Li, J T Wang, Y Jiang, X Wang, W Y Shi
Objective: To evaluate the efficacy of modified deep lamellar keratoplasty (DLKP) combined with antiviral medications for severe herpes necrotizing stromal keratitis. Methods: Retrospective case series study. Modified DLKP was performed in combination with antiviral medications in fifty patients (50 eyes) with severe necrotizing stromal keratitis, which was unresponsive to systemic and topical antiviral treatment for 1 week, at Shandong Eye Hospital. Before surgery, the operated eyes were examined using slit-lamp microscopy...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29419683/a-10-year-monitoring-of-the-eyesight-in-patients-after-kidney-transplantation
#18
Dorota Raczyńska, Mateusz Ślizień, Beata Bzoma, Alicja Dębska-Ślizień, Leopold Glasner, Krystyna Raczyńska
A pilot study of a 10-year analysis of the eyesight characteristics in patients after renal transplantation with a view to a later wider study of the same population.The study encompassed 50 eyes in 25 patients who underwent renal transplantation in the years 2007 and 2008. All patients underwent: visual acuity measurement, tonometry, slit lamp examination, and spectroscopic optical coherence tomography.Changes in the eyes observed during the 10-year observation period included mostly: cataract (48%), hypertensive angiopathy (28%), diabetic macular edema (16%), and glaucoma (16%)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29319881/systemic-il-2-anti-il-2ab-complex-combined-with-sublingual-immunotherapy-suppresses-experimental-food-allergy-in-mice-through-induction-of-mucosal-regulatory-t-cells
#19
Paola L Smaldini, Fernando Trejo, José L Cohen, Eliane Piaggio, Guillermo H Docena
Therapeutic tolerance restoration has been proven to modify food allergy in patients and animal models and although sublingual immunotherapy (SLIT) has showed promise, combined therapy may be necessary to achieve a strong and long-term tolerance. In this work, we combined SLIT with systemic administration of IL-2 associated with an anti-IL-2 monoclonal antibody (IL-2/anti-IL-2Ab complex or IL-2C) to reverse the IgE-mediated experimental allergy. Balb/c mice were sensitized with cholera toxin and milk proteins and orally challenged with allergen to elicit hypersensitivity reactions...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29305292/corneal-nerve-regeneration-after-herpes-simplex-keratitis-a-longitudinal-in-vivo-confocal-microscopy-study
#20
Hamid-Reza Moein, Ahmad Kheirkhah, Rodrigo T Muller, Andrea C Cruzat, Deborah Pavan-Langston, Pedram Hamrah
PURPOSE: To evaluate the long-term alterations of corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). DESIGN: Prospective, longitudinal, cross sectional. METHODS: This study included 16 patients with a history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group...
April 2018: Ocular Surface
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