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https://www.readbyqxmd.com/read/29456714/foxk1-promotes-glioblastoma-proliferation-and-metastasis-through-activation-of-snail-transcription
#1
Haitao Xu, Shulan Huang, Xiaonan Zhu, Wangcheng Zhang, Xiangyang Zhang
Forkhead box K1 (FOXK1) has been identified to have a crucial function in development and oncogenesis. However, its role in glioblastoma has remained largely elusive and was therefore assessed in the present study. In human glioblastoma multiforme (GBM) tissue samples, FOXK1 was determined to be highly expressed compared with adjacent normal tissue samples. In addition, high levels of FOXK1 were detected in the T98G and LN18 GBM cell lines as compare with those in normal human astrocytes. Of note, high expression of FOXK1 was revealed to be associated with metastasis and tumor size...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456686/biochanin-a-extirpates-the-epithelial-mesenchymal-transition-in-a-human-lung-cancer
#2
Yan Wang, Jiao-Jiao Li, Yu-Min Chen
The natural iso-flavonoid, biochanin A, is categorized as a phytoestrogen and has been demonstrated to exhibit various pharmacological properties. However, no effects of biochanin A on lung cancer cell lines have been reported. Therefore, the present study aimed to demonstrate whether biochanin A has the ability to reduce lung cancer triggered pro-inflammatory effects from leukemic monocytes. We studied the release of cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6, from the cocultured cells of A427:AML-193...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455395/anti-cancer-effect-of-aquaporin-5-silencing-in-colorectal-cancer-cells-in-association-with-inhibition-of-wnt-%C3%AE-catenin-pathway
#3
Wei Wang, Qing Li, Tao Yang, Dongsheng Li, Feng Ding, Hongzhi Sun, Guang Bai
Aquaporin 5 (AQP5) is a water channel protein that is over-expressed in many tumors. Elevated expression of AQP5 is associated with poor prognosis of colorectal cancer. Yet, whether AQP5 plays a role in epithelial-mesenchymal transition (EMT) of colorectal cancer has not been reported until now. Here we aim to investigate the function of AQP5 in the EMT process of colorectal cancer. We transfected HCT116 and SW480 cells with AQP5-specific shRNA and verified the knockdown efficiency through western blotting and real-time PCR...
February 17, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29454197/cigarette-butts-may-have-low-toxicity-to-soil-dwelling-invertebrates-evidence-from-a-land-snail
#4
Hussan Gill, Kyler Rogers, Bilal Rehman, John Moynihan, Elizabeth A Bergey
Cigarette butts are a common form of litter that is often deposited on soil, where toxins from butts may affect soil-dwelling organisms. We examined possible toxicity of cigarette butts to the woodland snail Anguispira alternata using a toxicity study with cigarette butt effluent and a lab-based habitat choice experiment in which snails could feed or rest on areas with different butt densities. No mortality occurred during the 32-day toxicity study, which used six effluent concentrations ranging from 0 to 4butts/l (0 to 0...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29453950/towards-elimination-of-schistosomiasis-after-5000-years-of-endemicity-in-egypt
#5
REVIEW
Iman F Abou-El-Naga
Schistosomiasis is a snail-transmitted infectious disease caused by a long lasting infection with a blood fluke of the genus Schistosoma. S. haematobium and S. mansoni are the species endemic in Egypt. The country has been plagued and seriously suffered from schistosomiasis over the past 5000 years. Great strides had been done in controlling the disease since 1922. The history, epidemiology and the different control approaches were reviewed. Currently, Egypt is preparing towards schistosomiasis elimination by 2020...
February 14, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29451718/kiaa0247-inhibits-growth-migration-invasion-of-non-small-cell-lung-cancer-through-regulating-the-notch-pathway
#6
Yitong Xu, Hongjiu Ren, Jun Jiang, Qiongzi Wang, Muli Wudu, Qingfu Zhang, Hongbo Su, Chenglong Wang, Lihong Jiang, Xueshan Qiu
Lung cancer remains the leading cause of cancer-related death worldwide. Previous studies have shown that the novel KIAA0247 gene potentially targeted by the tumor suppressor p53 may inhibit the development of several cancers. However, the exact function of KIAA0247 in non-small-cell lung cancer (NSCLC) is unknown. The purpose of this study was to clarify the role of KIAA0247 in NSCLC. KIAA0247 expression was evaluated in tumors and adjacent normal tissues of 197 NSCLC patients by immunohistochemistry and real-time PCR and analyzed for association with clinicopathological parameters...
February 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29451595/evaluation-of-molluscicidal-activity-of-three-mangrove-species-avicennia-schaueriana-laguncularia-racemosa-and-rhizophora-mangle-and-their-effects-on-the-bioactivity-of-biomphalaria-glabrata-say-1818
#7
Renato Juvino de Aragão Mendes, Adalberto Alves Pereira Filho, Aline de Jesus Lustosa Nogueira, Karla Regina Freitas Araújo, Clícia Rosane Costa França, Iramar Borba de Carvalho, Natale Maria Lindoso da Silva, Alexandre Santana Azevedo, Ivone Garros Rosa
Schistosomiasis is a disease of global extent reaching populations in social vulnerability. One of the control measures of this parasitosis is the use of molluscicidal substances that can fight snails of the genus Biomphalaria, intermediate hosts of Schistosoma mansoni. The aim of this work was to study the toxic activity of three mangrove species (Avicennia schaueriana Stapf. & Leech, ex Moldenke, 1939, Laguncularia racemosa (L.) CF Gaertn, 1807 and Rhizophora mangle L. 1753) on the biological activities of snails Biomphalaria glabrata...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29449696/snail-regulates-bmp-and-tgf%C3%AE-pathways-to-control-the-differentiation-status-of-glioma-initiating-cells
#8
Laia Caja, Kalliopi Tzavlaki, Mahsa S Dadras, E-Jean Tan, Gad Hatem, Naga P Maturi, Anita Morén, Lotta Wik, Yukihide Watanabe, Katia Savary, Masood Kamali-Moghaddan, Lene Uhrbom, Carl-Henrik Heldin, Aristidis Moustakas
Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor β (TGFβ) promotes self-renewal and bone morphogenetic protein (BMP) induces differentiation of GSCs. BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in GSCs. Snail interacts with SMAD signaling mediators, generates a positive feedback loop of BMP signaling and transcriptionally represses the TGFB1 gene, decreasing TGFβ1 signaling activity...
February 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29445189/stk17b-promotes-carcinogenesis-and-metastasis-via-akt-gsk-3%C3%AE-snail-signaling-in-hepatocellular-carcinoma
#9
Yaliang Lan, Jihua Han, Yan Wang, Jiabei Wang, Guangchao Yang, Keyu Li, Ruipeng Song, Tongsen Zheng, Yingjian Liang, Shangha Pan, Xirui Liu, Mingxi Zhu, Yao Liu, Fanzheng Meng, Manzoor Mohsin, Yifeng Cui, Bo Zhang, Sharma Subash, Lianxin Liu
Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide with frequent intrahepatic and distant metastasis. Elucidating the underlying molecular mechanism that modulates HCC progression is critical for exploring novel therapeutic strategies. Serine/Threonine Kinase 17B (STK17B) is upregulated in HCC tissues, but its role in HCC progression remains elusive. In the present studies, we reported that STK17B had a critical role in HCC progression. STK17B was significantly upregulated in HCC cell lines and specimens, and patients with ectopic STK17B expression characterized with poor clinicopathological features...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29445069/expression-and-distribution-of-the-zinc-finger-protein-snai3-in-mouse-ovaries-and-pre-implantation-embryos
#10
Shujuan Guo, Xing-Yu Yan, Feifei Shi, Ke Ma, Zi-Jiang Chen, Cong Zhang
The Snail gene family includes Snai1, Snai2, and Snai3 that encode zinc finger-containing transcriptional repressors in mammals. The expression and localization of SNAI1 and SNAI2 have been studied extensively during folliculogenesis, ovulation, luteinization, and embryogenesis in mice. However, the role of SNAI3 is unknown. In this study, we investigated the expression of SNAI3 during these processes. Our immunohistochemistry data showed that SNAI3 first appeared in oocytes by postnatal day (PD) 9. Following this, SNAI3 was found to be expressed consistently in theca and interstitial cells, along with oocytes...
February 15, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29442320/amphibian-zic-genes
#11
Christa Merzdorf, Jennifer Forecki
Studies in Xenopus laevis have greatly contributed to understanding the roles that the Zic family of zinc finger transcription factors play as essential drivers of early development. Explant systems that are not readily available in other organisms give Xenopus embryos a unique place in these studies, facilitated by the recent sequencing of the Xenopus laevis genome. A number of upstream regulators of zic gene expression have been identified, such as inhibition of BMP signaling, as well as calcium, FGF, and canonical Wnt signaling...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29441907/microrna-335-inhibits-colorectal-cancer-hct116-cells-growth-and-epithelial-mesenchymal-transition-emt-process-by-targeting-twist1
#12
Jingyuan Wang, Xuemei Wang, Fengjun Liu, Yuguang Fu
Colorectal cancer is one of the most commonly diagnosed cancers. Recently, several microRNAs (miRNAs) have been characterized as oncogenes or tumor suppressors in colorectal cancer. This study was aimed to explore the tumor suppressive effects and its underling mechanism of miR-335 on colorectal cancer cells. Human colorectal cancer HCT116 cells were employed and the expression of miR-335 in cells was altered by transfection with miR-335 mimic and miR-335 inhibitor. Thereafter, CCK-8 assay, flow cytometry, Transwell assay and Western blotting were used to detect cell viability, apoptosis, migration, invasion, and the expression of epithelial-mesenchymal transition (EMT)-related proteins...
August 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441415/novel-approach-to-study-gastropod-mediated-innate-immune-reactions-against-metastrongyloid-parasites
#13
Felipe Penagos-Tabares, Malin K Lange, Anika Seipp, Ulrich Gärtner, Helena Mejer, Anja Taubert, Carlos Hermosilla
The anthropozoonotic metastrongyloid nematodes Angiostrongylus cantonensis and Angiostrongylus costaricensis, as well as Angiostrongylus vasorum, Crenosoma vulpis, Aelurostrongylus abstrusus and Troglostrongylus brevior are currently considered as emerging gastropod-borne parasites and have gained growing scientific attention in the last years. However, the knowledge on invertebrate immune responses and on how metastrongyloid larvae are attacked by gastropod immune cells is still limited. This work aims to describe an in vitro system to investigate haemocyte-derived innate immune responses of terrestrial gastropods induced by vital axenic metastrongyloid larvae...
February 13, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29435237/save-your-host-save-yourself-caste-ratio-adjustment-in-a-parasite-with-division-of-labor-and-snail-host-survival-following-shell-damage
#14
Colin MacLeod, Robert Poulin, Clément Lagrue
Shell damage and parasitic infections are frequent in gastropods, influencing key snail host life-history traits such as survival, growth, and reproduction. However, their interactions and potential effects on hosts and parasites have never been tested. Host-parasite interactions are particularly interesting in the context of the recently discovered division of labor in trematodes infecting marine snails. Some species have colonies consisting of two different castes present at varying ratios; reproductive members and nonreproductive soldiers specialized in defending the colony...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29434190/mir-22-suppresses-epithelial-mesenchymal-transition-in-bladder-cancer-by-inhibiting-snail-and-mapk1-slug-vimentin-feedback-loop
#15
Mingjie Xu, Jiangfeng Li, Xiao Wang, Shuai Meng, Jiaying Shen, Song Wang, Xin Xu, Bo Xie, Ben Liu, Liping Xie
MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of bladder cancer (BCa). MiR-22 was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in BCa remain unclear. Here, we find that miR-22 is frequently downregulated in BCa tissues compared with adjacent non-cancerous tissues. Overexpression of miR-22 significantly inhibits proliferation, migration, and invasion of BCa cells both in vitro and in vivo...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29432845/adam9-mediates-the-interleukin-6-induced-epithelial-mesenchymal-transition-and-metastasis-through-ros-production-in-hepatoma-cells
#16
Yinying Dong, Zhifeng Wu, Mingyan He, Yuhan Chen, Yixing Chen, Xiaoyun Shen, Xiaomei Zhao, Li Zhang, Baoying Yuan, Zhaochong Zeng
Interleukin (IL)-6 has been implicated in the invasion and metastasis of hepatocellular carcinoma (HCC). However, the molecular events that mediate this process are poorly understood. Here, we showed that IL-6 promoted the epithelial-mesenchymal transition (EMT) in HCC cell lines, and upregulated a disintegrin and metalloprotease 9 (ADAM9) expression by activating the JNK signaling pathway. ADAM9 was upregulated in human HCCs which promoted HCC cell invasion and the EMT by interacting with NADPH oxidase 1 and inducing reactive oxygen species generation...
February 9, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29431637/silencing-the-snail-dependent-rna-splice-regulator-esrp1-drives-malignant-transformation-of-human-pulmonary-epithelial-cells
#17
Tonya C Walser, Zhe Jing, Linh M Tran, Ying Q Lin, Natalie Yakobian, Gerald Wang, Kostyantyn Krysan, Li X Zhu, Sherven Sharma, Mi-Heon Lee, John A Belperio, Aik T Ooi, Brigitte N Gomperts, Jerry W Shay, Jill E Larsen, John D Minna, Long-Sheng Hong, Michael C Fishbein, Steven M Dubinett
Epithelial-to-mesenchymal transition (EMT) is organized in cancer cells by a set of key transcription factors, but the significance of this process is still debated including in non-small cell lung cancer (NSCLC). Here we report increased expression of the EMT-inducing transcription factor Snail in premalignant pulmonary lesions, relative to histologically normal pulmonary epithelium. In immortalized human pulmonary epithelial cells and isogenic derivatives, we documented Snail-dependent anchorage-independent growth in vitro and primary tumor growth and metastatic behavior in vivo...
February 5, 2018: Cancer Research
https://www.readbyqxmd.com/read/29429273/-effects-of-monobutyl-phthalate-on-migration-and-invasion-of-mouse-leydig-tumor-cells
#18
P Gong, H C Lu, C Zhang, S S Chen, Y B Wang
Objective: This study aimed to investigate the influence of monobutyl phthalate (MBP) on the expressions of epithelial-mesenchymal transition (EMT)-related proteins, migration and invasion of mouse Leydig tumor cells (MLTC-1) cells. Methods: After exposed to different doses of MBP (0、10(-7)、10(-6), 10(-5), 10(-4), 10(-3) mol/L) for 24 h or 48 h, cell viability was determined by 3-(4 5-dimethyl-2-thiazolyl)-2 5-diphenyl-2-H-tetrazolium bromide (MTT) assay. Expressions of vimentin, E-cadherin, N-cadherin and Snail proteins related to EMT were detected by Western blot...
February 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29427661/mir-199a-5p-inhibits-the-progression-of-papillary-thyroid-carcinoma-by-targeting-snai1
#19
Sugang Ma, Wei Jia, Shiyu Ni
BACKGROUND: Increasing evidence has emphasized the important roles of differentially expressed miRNAs in papillary thyroid cancer (PTC) development. miR-199a-5p was previously documented to be downregulated in PTCs compared with normal thyroids. However, the role of miR-199a-5p in the progression of PTC and the underlying mechanism remain to be further addressed. METHODS: miR-199a-5p and snail family zinc finger 1 (SNAI1) mRNA expressions in PTC tissues and cells were detected by qRT-PCR...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29426476/larval-development-of-aelurostrongylus-abstrusus-in-experimentally-infected-rumina-decollata-snails
#20
Natalia M Cardillo, Mariano Ercole, Fernando Fariña, Mariana Pasqualetti, Yanina Loiza, Matías Pérez, Ayelén Bonboni, Mabel Ribicich
Aelurostrongylus abstrusus is a lungworm distributed worldwide that affects wild and domestic cats, causing bronchopneumonia of varying intensity. Snails serve as intermediate hosts. The aim of the present study was to assess the larval development of A. abstrusus in R. decollata snails and to investigate its potential as an intermediate host. For this purpose, first-stage larvae (L1) of A. abstrusus were obtained from the faeces of naturally infected cats. Doses of 500 L1/snail were given to 24 R. decollata snails, placed on the soil of the breeder chamber, and maintained under laboratory conditions...
February 15, 2018: Veterinary Parasitology
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