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https://www.readbyqxmd.com/read/29227545/overexpression-of-sirt6-is-a-novel-biomarker-of-malignant-human-colon-carcinoma
#1
Chang-Hui Geng, Chun-Ling Zhang, Jing-Yan Zhang, Ping Gao, Miao He, Yan-Lin Li
Sirt family has been reported playing a significant role in the cancer develop, special its deacetylase activity plays a key function, but whether SIRT6 plays a role in mediating tumor EMT and metastasis in colon cancer has not been explored. Here, the mass spectrometry and co-immunoprecipitation assays were utilized to detect that SIRT6 was physically associated with transcription factor snail. Most important, HCT116 cells transfected with SIRT6 shRNA reversed EMT, while increased the expression of TET1, and the HCT116 cells transfected with SIRT6 displayed the contrary tendency...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29225593/diverse-cone-snail-species-harbor-closely-related-streptomyces-species-with-conserved-chemical-and-genetic-profiles-including-polycyclic-tetramic-acid-macrolactams
#2
Michelle Quezada, Cuauhtemoc Licona-Cassani, Pablo Cruz-Morales, Angela A Salim, Esteban Marcellin, Robert J Capon, Francisco Barona-Gómez
Streptomyces are Gram-positive bacteria that occupy diverse ecological niches including host-associations with animals and plants. Members of this genus are known for their overwhelming repertoire of natural products, which has been exploited for almost a century as a source of medicines and agrochemicals. Notwithstanding intense scientific and commercial interest in Streptomyces natural products, surprisingly little is known of the intra- and/or inter-species ecological roles played by these metabolites. In this report we describe the chemical structures, biological properties, and biosynthetic relationships between natural products produced by Streptomyces isolated from internal tissues of predatory Conus snails, collected from the Great Barrier Reef, Australia...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29225023/origins-and-specification-of-the-drosophila-wing
#3
David Requena, Jose Andres Álvarez, Hugo Gabilondo, Ryan Loker, Richard S Mann, Carlos Estella
The insect wing is a key evolutionary innovation that was essential for insect diversification. Yet despite its importance, there is still debate about its evolutionary origins. Two main hypotheses have been proposed: the paranotal hypothesis, which suggests that wings evolved as an extension of the dorsal thorax, and the gill-exite hypothesis, which proposes that wings were derived from a modification of a pre-existing branch at the dorsal base (subcoxa) of the leg. Here, we address this question by studying how wing fates are initially specified during Drosophila embryogenesis, by characterizing a cis-regulatory module (CRM) from the snail (sna) gene, sna-DP (for dorsal primordia)...
November 30, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29224622/increased-activity-of-%C3%AE-glucuronidase-variants-produced-by-site-directed-mutagenesis
#4
Xiaolei Zhang, Pongkwan Sitasuwan, Gary Horvath, Jia Yang, Yuzhe Nie, Margarita Marinova, L Andrew Lee, Qian Wang
β-glucuronidase (BGus) is an essential glycosyl hydrolase which has been widely used in biological and biomedical applications. In this paper, we report the construction and screening of nineteen Escherichia coli BGus (EBGus) mutants using site-directed mutagenesis. The mutants G559N, G559S and G559T showed a 3-5 fold increase in enzyme activity in comparison to wild type EBGus. In particular, G559S, with the highest activity, showed 2-6 fold enhanced activity compared to abalone and snail BGus extracts. Moreover, the glycine to serine mutagenesis for the same site in Staphylococcus sp...
February 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29222665/small-but-diverse-larval-trematode-communities-in-the-small-freshwater-planorbids-gyraulus-albus-and-segmentina-nitida-gastropoda-pulmonata-from-the-ruhr-river-germany
#5
J Schwelm, M Soldánová, T Vyhlídalová, B Sures, C Selbach
In contrast to the well-studied trematode fauna of lymnaeid snails, only little is known about the role of small planorbid snails as first intermediate hosts for trematodes in temperate freshwater systems. This study aims at closing this gap by assessing the diversity and composition of larval trematode communities in Gyraulus albus and Segmentina nitida in a Central European reservoir system, and by providing an updated comprehensive review of the published trematode records of these snail hosts. A total of 3691 planorbid snails (3270 G...
December 8, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29218776/is-the-consumption-of-snail-meat-actually-healthy-an-analysis-of-the-osteotropic-influence-of-snail-meat-as-a-sole-source-of-protein-in-growing-rats
#6
R P Radzki, M Bieńko, P Polak, K Szkucik, M Ziomek, M Ostapiuk, J Bieniaś
The study was aimed at determining the osteotropic effects of diets containing snail meat as a sole protein source. In our experiment, we tested three different diets incorporating snail meat originating from Helix pomatia (HP), Cornu.aspesa maxima (CAM) and Cornu.aspersum aspersum (CAA) and compared these to a control diet (CON) in which casein was the source of protein. In all diets, the protein content amounted to 10%, as calculated on a dry weight basis. In the study, forty male Wistar rats with an initial body mass of 50 ± 2 g were randomly placed within the control and three experimental groups...
December 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29218012/anti-tumor-effect-of-rhaponticum-uniflorum-ethyl-acetate-extract-by-regulation-of-peroxiredoxin1-and-epithelial-to-mesenchymal-transition-in-oral-cancer
#7
Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang
Objective: To explore whether Rhaponticum uniflorum (R. uniflorum) had anti-tumor effects in oral cancer and investigate the molecular mechanisms involved in these anti-tumor effects. Methods: Chemical compositions of R. uniflorum ethyl acetate (RUEA) extracts were detected by ultra-performance liquid chromatography-Q/time-of-flight mass spectrometry (UPLC-Q/TOF-MS), followed by pharmacology-based network prediction analysis. The effects of RUEA extracts on proliferation, apoptosis, migration, and invasion ability of human oral squamous cell carcinoma (OSCC) cell line SCC15 were evaluated by CCK8 assay, Annexin V- fluorescein isothiocyanate/propidium iodide staining, wound healing assay, and Matrigel invasion assay, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29216625/missing-links-in-epithelial-mesenchymal-transition-long-non-coding-rnas-enter-the-arena
#8
Lei Wang, Fan Yang, Lin-Tao Jia, An-Gang Yang
Cancer metastasis occurs through a series of sequential steps, which involves dissemination of tumor cells from a primary site and colonization in distant tissues. To promote the invasion-metastasis cascade, carcinoma cells usually initiate a cell-biological program called epithelial-mesenchymal transition (EMT), which is orchestrated by a set of master regulators, including TGF-β, Snail, ZEB and Twist families. The biological activities of these molecules are tightly regulated by a variety of cell-intrinsic pathways as well as extracellular cues...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29216489/alginate-affects-agglomeration-state-and-uptake-of-14c-labeled-few-layer-graphene-by-freshwater-snails-implications-for-the-environmental-fate-of-graphene-in-aquatic-systems
#9
Yu Su, Chi Huang, Fenxiao Lu, Xin Tong, Junfeng Niu, Liang Mao
Understanding of the interaction of graphene with natural polysaccharides (e.g., alginate) is crucial to elucidate its environmental fate. We investigated the impact of alginate on the agglomeration and stability of 14C-labeled few-layer graphene (FLG) in varying concentrations of monovalent (NaCl) and divalent (CaCl2) electrolytes. Enhanced agglomeration occurred at high CaCl2 concentrations (≥5 mM) due to the alginate gel networks formation in the presence of Ca2+. FLG enmeshed within extended alginate gel networks was observed under transmission electron microscope and atomic force microscope...
December 4, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29215605/cone-snails-a-big-store-of-conotoxins-for-novel-drug-discovery
#10
REVIEW
Bingmiao Gao, Chao Peng, Jiaan Yang, Yunhai Yi, Junqing Zhang, Qiong Shi
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery. These venomous snails capture prey using a diverse array of unique bioactive neurotoxins, usually named as conotoxins or conopeptides. These conotoxins have proven to be valuable pharmacological probes and potential drugs due to their high specificity and affinity to ion channels, receptors, and transporters in the nervous systems of target prey and humans...
December 7, 2017: Toxins
https://www.readbyqxmd.com/read/29214772/pseudolaric-acid-b-inhibits-proliferation-invasion-and-epithelial-to-mesenchymal-transition-in-human-pancreatic-cancer-cell
#11
Xiaoyu Li, Xianzhi Zhao, Wen Song, Zibin Tian, Lin Yang, Qinghui Niu, Qi Zhang, Man Xie, Bin Zhou, Yonghong Xu, Jun Wu, Cuiping Zhang
PURPOSE: This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible mechanism. MATERIALS AND METHODS: The pancreatic cancer cell line SW1990 was cultured and treated with PAB dose- and time-dependent manners. Cell proliferation and invasion ability were measured by MTT assay and Matrigel/Transwell test, respectively. Semi-quantitative real-time polymerase chain reaction and Western blotting were conducted to detect the expression of EMT markers and the key molecules...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214170/nlrp1-overexpression-is-correlated-with-the-tumorigenesis-and-proliferation-of-human-breast-tumor
#12
Yuxian Wei, Hongyan Huang, Zhu Qiu, Hongzhong Li, Jinxiang Tan, Guosheng Ren, Xiaoyi Wang
Recent studies suggest that nucleotide-binding domain leucine-rich repeat protein 1 (NLRP1) is a pivotal factor in the inflammatory process. However, the role of NLRP1 in breast cancer pathogenesis remains unclear. The aim of this study was to examine the expression and function of NLRP1 in breast cancer. We found that NLRP1 was widely expressed in 83% (60/72) of primary breast cancer tissue. NLRP1 expression level was higher in primary breast cancer tissue than in adjacent noncancerous tissue (p < 0.001) and NLRP1 expression was associated with lymph node metastasis (p = 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29213108/the-potential-therapeutic-effect-of-melatonin-on-human-ovarian-cancer-by-inhibition-of-invasion-and-migration-of-cancer-stem-cells
#13
Maryam Akbarzadeh, Ali Akbar Movassaghpour, Hossein Ghanbari, Maryam Kheirandish, Nazila Fathi Maroufi, Reza Rahbarghazi, Mohammad Nouri, Nasser Samadi
There is an urgent need to identify targeting molecules to control invasion and metastasis in cancer patients. We first isolated cancer stem cells (CSCs) from SKOV3 ovarian cancer cells and then investigated the role of melatonin in invasiveness and migration of CSCs compared to SKOV3 cells. The proportion of CSCs in SKOV3 cells was as low as 1.28% with overexpression of both CD133 and CD44. The ability of spheroid formation along with SOX2 overexpression revealed a high self-renewal potential in isolated cells...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212304/the-pentose-phosphate-pathway-as-a-potential-target-for-cancer-therapy
#14
REVIEW
Eunae Sandra Cho, Yong Hoon Cha, Hyun Sil Kim, Nam Hee Kim, Jong In Yook
During cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a resource-limited environment which they must escape. Increasing evidence indicates the importance of nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis in the survival of cancer cells under metabolic stress conditions, such as metabolic resource limitation and therapeutic intervention. NADPH is essential for scavenging of reactive oxygen species (ROS) mainly derived from oxidative phosphorylation required for ATP generation...
December 7, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29210355/neuroangiostrongyliasis-the-subarachnoid-phase-and-its-implications-for-anthelminthic-therapy
#15
Paul Prociv, Megan Turner
Infection with the Rat Lungworm Angiostrongylus cantonensis is the leading cause of human eosinophilic meningoencephalitis worldwide. From its origins in southeastern Asia, the parasite was spread extensively throughout the twentieth century and is now established in many of the world's warmer regions. Its clinical effects range from mild and transient symptoms, usually headache with peripheral nerve dysfunction, to severe and permanent central nervous system (CNS) damage, occasionally fatal. The severity and prognosis of disease are determined by the larval dose, acquired by ingesting infected intermediate hosts (slugs and snails) or, less often, paratenic hosts, such as crabs, shrimps, frogs, and monitor lizards...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29210316/long-living-rna-in-the-cns-of-terrestrial-snail
#16
Victor N Ierusalimsky, Pavel M Balaban
Click-iT method can be used to trace the neurons where the newly synthesized RNA transcripts occur. Our experiments performed with the CNS of terrestrial mollusk Helix demonstrate that 5-ethynyluridine (EU) is selectively incorporated in RNA but not in DNA. The time of EU accumulation necessary for its detection was about several hours. EU was injected into the body cavity of adult mollusks, and was detectable in neurons for several days. In juveniles, EU was introduced via bathing of snails in the EU-containing saline, and was reliably detected within time period of several weeks...
December 6, 2017: RNA Biology
https://www.readbyqxmd.com/read/29209857/feeding-behavior-of-an-aquatic-snail-as-a-simple-endpoint-to-assess-the-exposure-to-cadmium
#17
Álvaro Alonso, Guillermo Valle-Torres
One of the aims of ecotoxicology is the assessment of the effects of chemicals on the ecosystems. Bioassays assessing lethality are frequently used in ecotoxicology, however they usually employ supra-environmental toxic concentrations. Toxicity tests employing behavioral endpoints may present a balance between simplicity (i.e., laboratory bioassays) and complexity (i.e., relevant ecological effects). The aim of this study was to develop a feeding behavioral bioassay with the aquatic snail, Potamopyrgus antipodarum, which included a 2 days exposure to cadmium, followed by a 9 days post-exposure observational period...
December 5, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29209579/unanticipated-discovery-of-two-rare-gastropod-molluscs-from-recently-located-hydrothermally-influenced-areas-in-the-okinawa-trough
#18
Chong Chen, Hiromi Kayama Watanabe, Junichi Miyazaki, Shinsuke Kawagucci
Background: The deep-sea hydrothermal vent is one of the most 'extreme' environments in the marine realm. Few species are capable of inhabiting such ecosystems, despite extremely high productivity there supported by microbial chemosynthesis, leading to high biomass and low species richness. Although gastropod molluscs are one of the main constituents of megafaunal communities at vent ecosystems, most species belong to several typical families (e.g., Provannidae, Peltospiridae, Lepetodrilidae) specialised and adapted to life at vents...
2017: PeerJ
https://www.readbyqxmd.com/read/29207558/three-new-cytotoxic-steroidal-glycosides-isolated-from-conus-pulicarius-collected-in-kosrae-micronesia
#19
Yeon-Ju Lee, Saem Han, Su Hyun Kim, Hyi-Seung Lee, Hee Jae Shin, Jong Seok Lee, Jihoon Lee
Three new sulfated steroidal glycosides (3-5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI50 values down to 0.49 μM) against the K562 human leukemia cell line.
December 4, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29206937/functional-impact-of-microrna-regulation-in-models-of-extreme-stress-adaptation
#20
Kyle K Biggar, Kenneth B Storey
When confronted with severe environmental stress, some animals are able to undergo a substantial reorganization of their cellular environment that enables long-term survival. One molecular mechanism of adaptation that has received considerable attention in recent years has been the action of reversible transcriptome regulation by microRNA. The implementation of new computational and high-throughput experimental approaches have started to uncover the vital contributions of microRNA towards stress adaptation...
December 1, 2017: Journal of Molecular Cell Biology
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