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JOURNAL ARTICLE
Wanting Yang, Ming Yin, Jiehong Zhou, Yun Zhu, Beibei Ye, Hui Shi, Bingjie Zhang, Can Yue, Yifeng Zhang, Hongxun Wu, Haohao Li, Xuliang Xia, Shufang Yang, Buyun Ma
BACKGROUND: The current preoperative malignancy risk evaluation for thyroid nodules involves stepwise diagnostic modalities including ultrasonography, thyroid function serology and fine-needle aspiration (FNA) cytopathology, respectively. We aimed to substantiate the stepwise contributions of each diagnostic step and additionally investigate the diagnostic significance of quantitative chromogenic imprinted gene in-situ hybridization (QCIGISH)-an adjunctive molecular test based on epigenetic imprinting alterations...
April 12, 2024: Chinese Clinical Oncology
#22
JOURNAL ARTICLE
Laura Gallina, Veronica Facile, Nicola Roda, Maria Chiara Sabetti, Alessia Terrusi, Lorenza Urbani, Martina Magliocca, Kateryna Vasylyeva, Francesco Dondi, Andrea Balboni, Mara Battilani
Feline leukemia virus (FeLV) is responsible for feline leukemia syndrome in domestic cats. The prevention and control of disease caused by FeLV are primarily based on vaccination and identification and isolation of infected subjects. Antigen diagnostic methods, which are the most widely used in clinical practices, can be associated to molecular tests to characterize the FeLV detected. In this study, a quantitative SYBR Green Real-Time PCR (qPCR) assay was used to detect FeLV proviral DNA in blood samples from antigen positive cats referred to a veterinary teaching hospital in Northern Italy in 2018-2021...
April 22, 2024: Veterinary Research Communications
#23
JOURNAL ARTICLE
G B Spoelstra, S N Blok, L Reali Nazario, L Noord, Y Fu, N A Simeth, F F A IJpma, M van Oosten, J M van Dijl, B L Feringa, W Szymanski, P H Elsinga
INTRODUCTION: Bacterial infections are a major problem in medicine, and the rapid and accurate detection of such infections is essential for optimal patient outcome. Bacterial infections can be diagnosed by nuclear imaging, but most currently available modalities are unable to discriminate infection from sterile inflammation. Bacteria-targeted positron emission tomography (PET) tracers have the potential to overcome this hurdle. In the present study, we compared three 18 F-labelled PET tracers based on the clinically applied antibiotic vancomycin for targeted imaging of Gram-positive bacteria...
April 22, 2024: European Journal of Nuclear Medicine and Molecular Imaging
#24
JOURNAL ARTICLE
Fan Yang, Junyi Shen, Zhiming Zhao, Wei Shang, Hui Cai
Rheumatoid arthritis (RA) is a persistent autoimmune condition characterized by synovitis and joint damage. Recent findings suggest a potential link to abnormal lactate metabolism. This study aims to identify lactate metabolism-related genes (LMRGs) in RA and investigate their correlation with the molecular mechanisms of RA immunity. Data on the gene expression profiles of RA synovial tissue samples were acquired from the gene expression omnibus (GEO) database. The RA database was acquired by obtaining the common LMRDEGs, and selecting the gene collection through an SVM model...
April 22, 2024: Scientific Reports
#25
JOURNAL ARTICLE
Satoshi Fujii
As genomic medicine advances, opportunities for molecular pathology diagnosis by pathologists to be used as companion diagnostics is increasing. Pathological specimens must be useful not only for pathological diagnosis, but also for genetic testing panel and molecular pathology diagnosis. Companion diagnostics performed by pathologists uses immunohistochemical staining and fluorescence in situ hybridization to determine patient eligibility for molecular target drugs and immune checkpoint inhibitors. By accurately observing a wide variety of diagnostic criteria and performing with high precision, pathological diagnosis will become closer to therapeutic pathology...
April 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#26
REVIEW
Pengfei Cui, Xiaoyi Li, Caihua Huang, Donghai Lin
Cancer cachexia (CC) is a devastating metabolic syndrome characterized by skeletal muscle wasting and body weight loss, posing a significant burden on the health and survival of cancer patients. Despite ongoing efforts, effective treatments for CC are still lacking. Metabolomics, an advanced omics technique, offers a comprehensive analysis of small-molecule metabolites involved in cellular metabolism. In CC research, metabolomics has emerged as a valuable tool for identifying diagnostic biomarkers, unravelling molecular mechanisms and discovering potential therapeutic targets...
April 21, 2024: Journal of Cachexia, Sarcopenia and Muscle
#27
REVIEW
Simone Dalm, Heying Duan, Andrei Iagaru
Each tumor has its own distinctive molecular identity. Treatment, therefore, should be tailored to this unique cancer phenotype. Theragnostics uses the same compound for targeted imaging and treatment, radiolabeled to an appropriate radionuclide, respectively. Gastrin-releasing peptide receptors (GRPRs) are overexpressed in prostate cancer, and radiolabeled GRPR antagonists have shown high diagnostic performance at staging and biochemical recurrence. Several GRPR-targeting theragnostic compounds have been developed preclinically...
April 20, 2024: PET Clinics
#28
JOURNAL ARTICLE
Z Nogareda Seoane, M C Mallón Araújo, A Calatayud Cubes, C Barberán Corral, Y Domínguez Novoa, A Cousillas Castiñeira, N Martínez Lago, J M de Matías Leralta, V Pubul Nuñez
OBJECTIVE: The aim of the study was evaluate the diagnostic performance of [68Ga]Ga-DOTA-TOC and [18 F]FDG PET/CT in patients with histologically proven neuroendocrine tumors (NETs), as well as the correlation of the visualized findings with the tumor grade. MATERIAL AND METHODS: We included 50 patients with NETs who underwent both [68Ga]Ga-DOTA-TOC and [18 F]FDG PET/TC. The pooled sensitivity of both scans was compared, as well as [68Ga]Ga-DOTA-TOC and [18 F]FDG for each tumor grade (grade 1/G1, grade 2/G2 and grade 3/G3)...
April 19, 2024: Revista española de medicina nuclear e imagen molecular
#29
JOURNAL ARTICLE
Yuanyuan Jiao, Xinze Liu, Jingxuan Shi, Jiaqi An, Tianyu Yu, Guming Zou, Wenge Li, Li Zhuo
BACKGROUND: Diabetic kidney disease (DKD) is a primary microvascular complication of diabetes with limited therapeutic effects. Delving into the pathogenic mechanisms of DKD and identifying new therapeutic targets is crucial. Emerging studies reveal the implication of ferroptosis and immune dysregulation in the pathogenesis of DKD, however, the precise relationship between them remains not fully elucidated. Investigating their interplay is pivotal to unraveling the pathogenesis of diabetic kidney disease, offering insights crucial for targeted interventions and improved patient outcomes...
April 20, 2024: Diabetology & Metabolic Syndrome
#30
JOURNAL ARTICLE
René Guérin, Anne-Lise Menard, Emilie Angot, Nicolas Piton, Pierre Vera, Lilian Schwarz, Jean-Christophe Sabourin, Marick Laé, Pierre-Alain Thiébaut
BACKGROUND: Alveolar soft part sarcoma is a rare tumour of soft tissues, mostly localized in muscles or deep soft tissues of the extremities. In rare occasions, this tumour develops in deep tissues of the abdomen or pelvis. CASE PRESENTATION: In this case report, we described the case of a 46 year old man who developed a primary splenic alveolar soft part sarcoma. The tumour displayed typical morphological alveolar aspect, as well as immunohistochemical profile notably TFE3 nuclear staining...
April 20, 2024: Diagnostic Pathology
#31
JOURNAL ARTICLE
Vladimira Hinić, Helena M B Seth-Smith, Sabrina Stammler, Adrian Egli
Current methods for plasmid-mediated AmpC β-lactamase (pAmpC) detection in routine microbiological laboratories are based on various phenotypic tests. Eazyplex®SuperBug AmpC assay is a molecular assay based on isothermal amplification for rapid detection of the most common pAmpC types from bacterial culture: CMY-2 group, DHA, ACC and MOX. Our aim was to evaluate the diagnostic performance of this assay. The assay was evaluated on 64 clinical isolates of Enterobacterales without chromosomal inducible AmpC, and with phenotypically confirmed AmpC production...
April 18, 2024: Journal of Microbiological Methods
#32
JOURNAL ARTICLE
Xilin Wang, Yandao Chen, Ting Chen, Longxiu Guo, Zhen Yang, Yan Chen, Zhiyang Yu, Xingmei Liu, Haiyan Wang
Little information is known regarding how the lagged pollution of polycyclic aromatic hydrocarbon (PAH) influenced the environment and human health after an e-waste dismantling site was rebuilt. This study investigated the characteristics, sources, and risk assessment of PAHs in a rebuilt e-waste site and its surrounding farmland by analyzing the samples of soil, dust, water, and vegetable. Concentrations of PAHs in soil, vegetable and water in the rebuilt site were relatively higher than in its surrounding farmland...
April 18, 2024: Science of the Total Environment
#33
JOURNAL ARTICLE
Ye Zhang, Mingxin Ni, Yuquan Tao, Meng Shen, Weichen Xu, Minmin Fan, Jinjun Shan, Haibo Cheng
OBJECTIVES: Although colorectal cancer (CRC) is the leading cause of cancer-related morbidity and mortality, current diagnostic tests for early-stage CRC and colorectal adenoma (CRA) are suboptimal. Therefore, there is an urgent need to explore less invasive screening procedures for CRC and CRA diagnosis. METHODS: Untargeted gas chromatography-mass spectrometry (GC-MS) metabolic profiling approach was applied to identify candidate metabolites. We performed metabolomics profiling on plasma samples from 412 subjects including 200 CRC patients, 160 CRA patients and 52 normal controls (NC)...
April 20, 2024: Metabolomics: Official Journal of the Metabolomic Society
#34
REVIEW
Himanshu Gupta, Sonal Sharma, Irina Gilyazova, Kapaettu Satyamoorthy
The eradication of Plasmodium parasites, responsible for malaria, is a daunting global public health task. It requires a comprehensive approach that addresses symptomatic, asymptomatic, and submicroscopic cases. Overcoming this challenge relies on harnessing the power of molecular diagnostic tools, as traditional methods like microscopy and rapid diagnostic tests fall short in detecting low parasitaemia, contributing to the persistence of malaria transmission. By precisely identifying patients of all types and effectively characterizing malaria parasites, molecular tools may emerge as indispensable allies in the pursuit of malaria elimination...
April 20, 2024: Molecular Biology Reports
#35
REVIEW
Inain Jaies, Feroz Ahmad Shah, Syed Shariq Nazir Qadiri, Imtiyaz Qayoom, Bilal Ahmad Bhat, Shabir Ahmad Dar, Farooz Ahmad Bhat
Fish health management is critical to aquaculture and fisheries as it directly affects sustainability and productivity. Fish disease diagnosis has taken a massive stride because of advances in immunological and molecular diagnostic tools which provide a sensitive, quick, and accurate means of identifying diseases. This review presents an overview of the main molecular and immunological diagnostic methods for determining the health of fish. The immunological techniques help to diagnose different fish diseases by detecting specific antigens and antibodies...
April 20, 2024: Molecular Biology Reports
#36
JOURNAL ARTICLE
Marco Cirronis, Sarah Schneemann, Janice Pettie, Guido Mannaioni, James W Dear
INTRODUCTION: Paracetamol (acetaminophen) overdose is a leading cause of acute liver failure in many Western countries. Diagnostic tools for this poisoning may be suboptimal in some cases and new biomarkers have been investigated. We investigated the role of capillary microRNA-122 (miR-122) as a prognostic biomarker of liver injury in the clinical management of patients with paracetamol overdose. METHODS: In a paracetamol overdose patient cohort, miR-122 was measured by quantitative polymerase chain reaction in a blood drop obtained by a finger prick at the end of an antidote cycle treatment with N-acetylcysteine treatment (12 h)...
April 20, 2024: Molecular Biology Reports
#37
REVIEW
Rui Zhang, Haitao Yang, Menghao Guo, Shuyan Niu, Yuying Xue
Mitophagy is a selective cellular process critical for the removal of damaged mitochondria. It is essential in regulating mitochondrial number, ensuring mitochondrial functionality, and maintaining cellular equilibrium, ultimately influencing cell destiny. Numerous pathologies, such as neurodegenerative diseases, cardiovascular disorders, cancers, and various other conditions, are associated with mitochondrial dysfunctions. Thus, a detailed exploration of the regulatory mechanisms of mitophagy is pivotal for enhancing our understanding and for the discovery of novel preventive and therapeutic options for these diseases...
April 20, 2024: Journal of Applied Toxicology: JAT
#38
JOURNAL ARTICLE
Colin R Zamecnik, Gavin M Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D Bair, Kristen J Wade, Christopher M Bartley, Kerry Kizer, Danillo G Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M Caspar, Jessica Alexander, Anne E Wapniarski, Rita P Loudermilk, Erica L Eggers, Kelsey C Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A Mann, Nicholas R Ragan, Adam Santaniello, Roland G Henry, Sergio E Baranzini, Scott S Zamvil, Joseph J Sabatino, Riley M Bove, Chu-Yueh Guo, Jeffrey M Gelfand, Richard Cuneo, H-Christian von Büdingen, Jorge R Oksenberg, Bruce A C Cree, Jill A Hollenbach, Ari J Green, Stephen L Hauser, Mitchell T Wallin, Joseph L DeRisi, Michael R Wilson
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster in approximately 10% of PwMS who share an autoantibody signature against a common motif that has similarity with many human pathogens...
April 19, 2024: Nature Medicine
#39
JOURNAL ARTICLE
Martin C Tammemägi, Gail E Darling, Heidi Schmidt, Meghan J Walker, Deanna Langer, Yvonne W Leung, Kathy Nguyen, Beth Miller, Diego Llovet, William K Evans, Daniel N Buchanan, Gabriela Espino-Hernandez, Usman Aslam, Amanda Sheppard, Aisha Lofters, Micheal McInnis, Julian Dobranowski, Steven Habbous, Christian Finley, Marianne Luettschwager, Erin Cameron, Caroline Bravo, Anna Banaszewska, Katherin Creighton-Taylor, Brenda Fernandes, Julia Gao, Alex Lee, Van Lee, Bogdan Pylypenko, Monica Yu, Erin Svara, Shivali Kaushal, Lynda MacNiven, Caitlin McGarry, Lauren Della Mora, Liz Koen, Jessica Moffatt, Michelle Rey, Marta Yurcan, Laurie Bourne, Gillian Bromfield, Melissa Coulson, Rebecca Truscott, Linda Rabeneck
Globally, lung cancer is the leading cause of cancer death. Previous trials demonstrated that low-dose computed tomography lung cancer screening of high-risk individuals can reduce lung cancer mortality by 20% or more. Lung cancer screening has been approved by major guidelines in the United States, and over 4,000 sites offer screening. Adoption of lung screening outside the United States has, until recently, been slow. Between June 2017 and May 2019, the Ontario Lung Cancer Screening Pilot successfully recruited 7,768 individuals at high risk identified by using the PLCOm2012noRace lung cancer risk prediction model...
April 2024: Nature Medicine
#40
JOURNAL ARTICLE
Rajiv Ranjit Nair, Aprameya Prasad, Omkar Bhatavdekar, Aira Sarkar, Kathleen L Gabrielson, Stavroula Sofou
UNLABELLED: Alpha-particle radionuclide-antibody conjugates are being clinically evaluated against solid tumors even when they moderately express the targeted markers. At this limit of lower tumor-absorbed doses, to maintain efficacy, the few(er) intratumorally delivered alpha-particles need to traverse/hit as many different cancer cells as possible. We complement antibody-radioconjugate therapies with a separate nanocarrier delivering a fraction of the same total injected radioactivity to tumor regions geographically different than those affected by targeting antibodies; these carrier-cocktails collectively distribute the alpha-particle emitters better...
April 20, 2024: European Journal of Nuclear Medicine and Molecular Imaging
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