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Eosinophillic Colitis

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https://www.readbyqxmd.com/read/29726281/exopolysaccharide-from-bifidobacterium-longum-subsp-longum-35624%C3%A2-modulates-murine-allergic-airway-responses
#1
E Schiavi, S Plattner, N Rodriguez-Perez, W Barcik, R Frei, R Ferstl, M Kurnik-Lucka, D Groeger, R Grant, J Roper, F Altmann, D van Sinderen, C A Akdis, L O'Mahony
Interactions between the host and the microbiota are thought to significantly influence immunological tolerance mechanisms at mucosal sites. We recently described that the loss of an exopolysaccharide (EPS) from Bifidobacterium longum 35624™ eliminated its protective effects in colitis and respiratory allergy murine models. Our goal was to investigate the immune response to purified EPS from B. longum 35624, determine if it has protective effects within the lung and identify the protective mechanisms. Isolated EPS from B...
May 4, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29624512/gastrointestinal-tract-vasculopathy-clinicopathology-and-description-of-a-possible-new-entity-with-protean-features
#2
Christine Y Louie, Michael A DiMaio, Gregory W Charville, Gerald J Berry, Teri A Longacre
Noninfectious gastrointestinal (GI) vasculopathic disorders are rare and are often overlooked in histopathologic examination or when forming differential diagnoses due to their rarity. However, involvement of the GI tract may lead to serious complications, including ischemia and perforation. Since awareness of the types of vasculopathy that may involve the GI tract is central to arriving at a correct diagnosis, we reviewed our institutional experience with GI tract vasculopathy in order to enhance diagnostic accuracy of these rare lesions...
April 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29620603/eosinophilic-gastroenteritis-and-colitis-not-yet-ready-for-the-big-leagues
#3
Noam Zevit, Glenn T Furuta
No abstract text is available yet for this article.
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29603385/downregulated-eosinophil-activity-in-ulcerative-colitis-with-concomitant-primary-sclerosing-cholangitis
#4
Maria Lampinen, Annika Fredricsson, Johan Vessby, Johana Fernandez Martinez, Alkwin Wanders, Fredrik Rorsman, Marie Carlson
Primary sclerosing cholangitis (PSC) is a chronic bile duct inflammation strongly connected to ulcerative colitis (UC). PSC is associated with an increased risk of colon cancer, but the link between the intestinal and the bile duct inflammation is still unknown. Also, the involvement of intestinal immune cells in the pathogenesis of PSC remains to be determined. The eosinophil granulocyte is one of the immune cells implicated in the inflammatory process of ulcerative colitis. This study was performed to determine how the accumulation and activation of intestinal eosinophils may differ between UC with and without concomitant PSC, and how this may be influenced by the cytokine/chemokine profile of the intestinal compartment...
March 30, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29533199/eosinophilic-gastroenteritis-and-other-eosinophilic-gut-diseases-distal-to-the-oesophagus
#5
REVIEW
Marjorie M Walker, Michael Potter, Nicholas J Talley
Under normal physiological conditions, eosinophils are present throughout the gastrointestinal tract distal to the squamous oesophagus. Increases in their numbers signify primary and secondary eosinophilic conditions. The rare primary eosinophilic diseases eosinophilic gastroenteritis and eosinophilic colitis affect fewer than ten in 100 000 people, and are characterised by numerous mucosal eosinophils, distributed in sheets and sometimes extending from the mucosa into the submucosa. Pathogenesis of these diseases is poorly understood, but food allergies and intestinal dysbiosis have been implicated...
April 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29469316/-clinical-features-of-imported-schistosomiasis-mansoni-in-beijing-city%C3%AF-a-report-of-6-cases
#6
Zou Yang, Wang Lei, Li Xiao-Li, Tian Xiao-Jun, Li Wei, An Yi-Jun, Qi Zhi-Qun, Li Jing-Jing, Wang Fei, Huang Min-Jun
OBJECTIVE: To analyze the clinical features of 6 patients with imported schistosomiasis mansoni, including the epidemic history, clinical manifestations, laboratory tests and therapeutic effect, so as to provide references for improving the levels of diagnosis and treatment of physicians. METHODS: The clinical data of 6 patients with imported schistosomiasis mansoni from January 2009 to July 2016 were collected and analyzed. RESULTS: All the 6 imported patients with schistosomiasis mansoni had a clear history of cercarial infested water exposure...
March 10, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29459804/-concurrent-lymphocytic-colitis-and-microscopic-enteritis-in-patients-with-chronic-diarrhea
#7
Fernando Arévalo, Greys Vergara, Susy Ruiz, Joseph Castillo, Fiorella Zurita, Eduardo Monge
INTRODUCTION: Lymphocytic colitis and microscopic enteritis are relatively common causes of chronic diarrhea and it is characterized by an intraepithelial lymphocytic infiltrate. There have been no previous reports of coexistence between these 2 pathologies. OBJECTIVE: To describe histological and clinical characteristic in patients with coexistence of lymphocytic colitis and microscopic enteritis. MATERIAL AND METHODS: All cases with simultaneous diagnosis of lymphocytic duodenosis and lymphocytic colitis were reevaluated during lapse time 2010-2016 in hospital Daniel Carrion...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29452215/lymphocytic-colitis-pathologic-predictors-of-response-to-therapy
#8
Namrata Setia, Lindsay Alpert, Kimberley Wj van der Sloot, Dora Colussi, Kathleen O Stewart, Joseph Misdraji, Hamed Khalili, Gregory Y Lauwers
While the presence of intraepithelial lymphocytosis with surface epithelial damage is a unifying feature of lymphocytic colitis, there are non-classical features that create morphologic heterogeneity between cases. Limited data are available on the significance of these secondary histologic features. Cases of lymphocytic colitis diagnosed between 2002 and 2013 were identified using the Research Patient Data Registry of a tertiary referral center. Diagnostic biopsy slides were reviewed and evaluated for histologic features of lymphocytic colitis...
February 13, 2018: Human Pathology
https://www.readbyqxmd.com/read/29438165/histologic-features-of-gastrointestinal-tract-biopsies-in-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura
#9
Christine Y Louie, Adam J Gomez, Richard K Sibley, Dorsey Bass, Teri A Longacre
Immunoglobulin A (IgA) vasculitis or Henoch-Schönlein purpura (HSP) typically occurs in the pediatric population, although rare cases also occur in adults. Gastrointestinal (GI) involvement is common. The "classic" histologic finding in IgA vasculitis (HSP) is leukocytoclastic vasculitis (LCV); other histologic features in biopsies of IgA vasculitis (HSP) have only been rarely described. The pathology archival files at our institution were searched for GI biopsies from patients with IgA vasculitis (HSP)...
April 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29422798/association-of-endoscopic-and-histological-remission-with-clinical-course-in-patients-of-ulcerative-colitis
#10
Vikram Narang, Ravneet Kaur, Bhavna Garg, Ramit Mahajan, Vandana Midha, Neena Sood, Ajit Sood
Background/Aims: The therapeutic goal for treating ulcerative colitis (UC) patients has shifted to achieving mucosal healing over the past few years. However, at present, limited data is available on the correlation between endoscopic findings and histological remission in patients with endoscopic mucosal healing. Methods: This was a prospective observational study conducted over a period of 18 months (January 2014 to June 2015) at Dayanand Medical College and Hospital, Ludhiana, Punjab, India...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29370679/fecal-calprotectin-beyond-intestinal-organic-diseases
#11
Gian P Caviglia, Davide G Ribaldone, Chiara Rosso, Giorgio M Saracco, Marco Astegiano, Rinaldo Pellicano
Fecal calprotectin (FC) is a calcium-binding protein with antimicrobic, imunomodulatory and antiproliferative properties that is mainly found in the cytoplasm of neutrophil granulocytes. During the last decades, FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. FC correlates with clinical scoring systems and endoscopic lesions in IBD and is considered a reliable biomarker for the prediction of clinical relapse or remission...
March 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29278974/abdominal-angiostrongyliasis-a-presentation-of-eosinophilic-granulomatous-colitis
#12
Timothy Walls, Dominick Cavuoti, Nandini Channabasappa, Mary Yang, Paul Southern, Michelle A Gill, Jason Y Park
We present a case of a 4-year-old girl with abdominal angiostrongyliasis who presented with persistent fevers, hepatosplenomegaly, acute abdominal pain, and eosinophilia. Computed tomography scan identified thickening of the ascending colon with a narrowed lumen. Endoscopic evaluation revealed ulcerations and erythema in the ascending colon. The microscopic findings in biopsies included active chronic inflammation with prominent eosinophils and granulomas. A subset of granulomas contained the eggs of Angiostrongylus costaricensis...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29259655/continuation-with-clozapine-after-eosinophilia-a-case-report
#13
Yen-Cheng Ho, Huang-Li Lin
Background: Clozapine-induced eosinophilia had been reported in several studies about blood dyscrasias in clozapine-treated patient. The largest study with 2404 patients in Italy found the incidence of 2.2% by criteria of more than 0.4 × 109 /l. Associated cases of pancreatitis, hepatitis, colitis, nephritis, and myocarditis were reported. Interestingly, incidence of myocarditis is high in Australia, but low in the rest of the world. In the following, we will present a case of clozapine-induced eosinophilia which spontaneous resolution was noted under continuation of clozapine...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29250655/eosinophilic-colitis-experience-in-a-large-tertiary-hospital
#14
Cristina Díaz Del Arco, Carlos Taxonera, Lourdes Estrada Muñoz, David Olivares, María Jesús Fernández Aceñero
BACKGROUND: Eosinophilic colitis (EC) is a rare and ill-defined entity with an unknown pathogenesis and an unsatisfactory treatment response. The standard histopathological criteria for EC diagnosis lack specificity and not all the cases fulfilling those criteria are considered clinically as EC and treated. The objective of this study is to refine diagnostic criteria for EC. METHODS: Retrospective study of all the cases with a histopathological diagnosis of EC in Hospital Clinico San Carlos (Madrid, Spain) from 2006 to 2016...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29177895/biopsy-diagnosis-of-colitis-an-algorithmic-approach
#15
Deepa T Patil, Robert D Odze
Certain types of colitides, such as collagenous colitis, lymphocytic colitis, and ischemic colitis, have distinct histologic features that allow for a specific diagnosis. However, in most colonic biopsy specimens, a definite diagnosis cannot be established on the basis of histology alone. Thus, in most cases of colitis, it is helpful to utilize a systematic approach in order to recognize patterns of injury. This information in conjunction with clinical and laboratory findings may help pathologists narrow the differential diagnosis and/or establish a more definite etiology for the patient's illness in order to guide clinical management...
November 25, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29132532/emerging-topics-in-gastroenterology
#16
REVIEW
Gretchen Irwin, Laura Mayans, Rick Kellerman
The bacteria and fungi in the human gut make up a community of microorganisms that lives in symbiosis with humans, engaging in numerous diverse interactions that influence health. This article outlines the current knowledge on emerging topics in gastroenterology, including microbiome and probiotics, fecal microbiota transplantation, cyclic vomiting syndrome, eosinophilic esophagitis, and microscopic colitis.
December 2017: Primary Care
https://www.readbyqxmd.com/read/29127496/classification-of-eosinophilic-disorders-of-the-small-and-large-intestine
#17
Aoife J McCarthy, Kieran Sheahan
Eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic gastroenteritis and eosinophilic colitis, have been increasing in prevalence in Western countries in recent years. Eosinophils are normally scanty in the gastrointestinal tract, and increased numbers of eosinophils can denote pathology. Normal values for tissue eosinophils vary widely between different segments of the colon, thus location of the biopsy is critically important for the interpretation of findings. However, no standard diagnostic criteria have been proposed for the diagnosis of eosinophilic gastroenteritis or eosinophilic colitis...
November 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29118877/eosinophilic-colitis-masquerading-as-malignancy-of-colon
#18
Tagore Sunkara, Arash Samarghandi, Sriharsha Dadana, Vinaya Gaduputi
Eosinophilic colitis (EC) is a rare part of spectrum of diseases called eosinophilic gastrointestinal disease (EGID). It was found to have bimodal distribution involving neonates and adults in age groups of 30 - 50 with male preponderance. We present this case of a 78-year-old woman who came to the hospital with abdominal pain, hematochezia and unintentional weight loss, and was found to have EC. This case was very unique given the age at presentation and the radiological findings mimicking malignancy. We reviewed the possible etiologies, clinical features, pathology, and treatment of EC along with the review of the literature...
October 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29103770/eosinophilic-colitis-case-series-and-literature-review
#19
Cristina Díaz Del Arco, Carlos Taxonera, David Olivares, Mª Jesús Fernández Aceñero
INTRODUCTION: Primary eosinophilic colitis (EC) in adults is a rare and poorly studied disease, with 3 case series, 2 database-based studies and 52 case reports published to date. METHODS: Retrospective study of all adult EC cases diagnosed in a large tertiary hospital (Hospital Clínico San Carlos, Madrid) between 2006 and 2016. We included all cases with a histopathological diagnosis of EC and we selected only those cases that were clinically recognized primary EC...
January 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29095349/clinical-implications-of-pediatric-colonic-eosinophilia
#20
Jacob Mark, Shahan D Fernando, Joanne C Masterson, Zhaoxing Pan, Kelley E Capocelli, Glenn T Furuta, Edwin F de Zoeten
OBJECTIVES: Pediatric colonic eosinophilia represents a confounding finding with a wide differential. It is often difficult to determine which children may progress to inflammatory bowel disease (IBD), which have an eosinophilic colitis (EC), and which may have no underlying pathology. There is little guidance for the practitioner on the approach to these patients. To define the clinical presentations of colonic eosinophilia and identify factors which may aid in diagnosis we reviewed patients with colonic eosinophilia and the clinicopathologic factors associated with their diagnoses...
October 31, 2017: Journal of Pediatric Gastroenterology and Nutrition
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