Martin Schäffler, Fernanda Sousa, Alexander Wenk, Leopoldo Sitia, Stephanie Hirn, Carsten Schleh, Nadine Haberl, Martina Violatto, Mara Canovi, Patrizia Andreozzi, Mario Salmona, Paolo Bigini, Wolfgang G Kreyling, Silke Krol
Nanoparticles (NP) and nanoparticulated drug delivery promise to be the breakthrough for therapy in medicine but raise concerns in terms of nanotoxicity. We present quantitative murine biokinetics assays using polyelectrolyte-multilayer-coated gold NP (AuNP, core diameter 15 and 80 nm; (198)Au radio-labeled). Those were stably conjugated either with human serum albumin (alb-AuNP) or apolipoprotein E (apoE-AuNP), prior to intravenous injection. We compare the biokinetics of protein-AuNP-conjugates with citrate-stabilized AuNP (cit-AuNP)...
March 2014: Biomaterials