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Rong Zhu, Hermann J Gruber, Peter Hinterdorfer
The number of ligand binding sites in neurotransmitter-sodium symporters has been determined by crystal structure analysis and molecular pharmacology with controversial results. Here, we designed molecular tools to measure the interaction forces between the serotonin transporter (SERT) and S-citalopram on the single-molecule level by means of atomic force microscopy. Force spectroscopy allows for the extraction of dynamic information under physiological conditions which is inaccessible via X-ray crystallography...
2018: Methods in Molecular Biology
Ivana Borišev, Jasminka Mrđanovic, Danijela Petrovic, Mariana Seke, Danica Jović, Branislava Srđenović, Natasa Latinovic, Aleksandar Djordjevic
Nanotechnology, focused on discovery and development of new pharmaceutical products is known as nanopharmacology, and one research area this branch is engaged in are nanopharmaceuticals. The importance of being nano has been particularly emphasized in scientific areas dealing with nanomedicine and nanopharmaceuticals. Nanopharmaceuticals, their routes of administration, obstacles and solutions concerning their improved application and enhanced efficacy have been briefly yet comprehensively described. Cancer is one of the leading causes of death worldwide and evergrowing number of scientific research on the topic only confirms that the needs have not been completed yet and that there is a wide platform for improvement...
August 17, 2018: Nanotechnology
Joanna Kisała, Kinga I Heclik, Krzysztof Pogocki, Dariusz Pogocki
The blood-brain barrier (BBB) is a complex system controlling two-way substances traffic between circulatory (cardiovascular) system and central nervous system (CNS). It is almost perfectly crafted to regulate brain homeostasis and to permit selective transport of molecules that are essential for brain function. For potential drug candidates, the CNS-oriented neuropharmaceuticals as well as for those of primary targets in the periphery, the extent to which a substance in the circulation gains access to the CNS seems crucial...
May 16, 2018: Current Medicinal Chemistry
Nicolas Bertrand, Philippe Grenier, Morteza Mahmoudi, Eliana M Lima, Eric A Appel, Flavio Dormont, Jong-Min Lim, Rohit Karnik, Robert Langer, Omid C Farokhzad
In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer nanoparticles to show how physicochemical characteristics influence blood circulation and early distribution. For particles with different diameters, surface hydrophilicity appears to mediate early clearance. Densities above a critical value of approximately 20 poly(ethylene glycol) chains (MW 5 kDa) per 100 nm2 prolong circulation times, irrespective of size...
October 3, 2017: Nature Communications
Kalakotla Shanker, Gottumukkala Krishna Mohan, Md Ashwaq Hussain, Naradala Jayarambabu, Poka Lakshmi Pravallika
Diabetes is a metabolic disorder characterized by hyperglycemia, altered carbohydrate, lipid and protein metabolism. In recent studies, Nanoscience and nanotechnology are blazing fields for researchers; for researchers; of late there has been a prodigious excitement in the field of nanopharmacology to study silver nanoparticle (SNP) synthesis using natural products. Biological methods have been used to synthesize SNPs using medicinally active plants having an antidiabetic role, and this made us to assess the biologically synthesized SNPs from the seed extract of Psoralea corylifolia using 1 mM silver nitrate solution...
January 2017: Pharmacognosy Magazine
Anna Radomska, Jarosław Leszczyszyn, Marek W Radomski
The very dynamic growth of nanotechnology, nanomaterials (sized 1-100 nm) and their medical applications over the past 10 years has promised to add a new impetus to the diagnostics and therapeutics of a wide range of human pathologies, including cancer, cardiovascular diseases and diseases of the central nervous system. This growth in nanomedicine also fuels advances in bioengineering, regenerative medicine and the development of medical devices. However, as with all new pharmaceuticals and medical devices, new opportunities are inherently accompanied by new challenges due to the ability of nanomaterials to interact with the body on the cellular, subcellular and molecular levels...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Ruiyan Zhang, Thomas Eckert, Thomas Lutteke, Stefan Hanstein, Axel Scheidig, Alexandre M J J Bonvin, Nikolay E Nifantiev, Tibor Kozar, Roland Schauer, Mushira Abdulaziz Enani, Hans-Christian Siebert
The Antimicrobial peptides (e.g. defensins, hevein-like molecules and food-protecting peptides like nisin) are able to interact specifically with contact structures on pathogen surfaces. Besides protein receptors, important recognition points for such contacts are provided by pathogen glycan chains or surface lipids. Therefore, structural data concerning surface exposed glycans and lipids are of the highest clinical interest since these recognition functions play a key role when optimising anti-infection therapies...
2016: Current Topics in Medicinal Chemistry
Krzysztof A Tomaszewski, Marek W Radomski, Maria Jose Santos-Martinez
In physiological conditions, the interactions between blood platelets and endothelial cells play a major role in vascular reactivity and hemostasis. By contrast, increased platelet activation contributes to the pathogenesis of vascular pathology such as atherosclerosis, thrombosis, diabetes mellitus, hypertension and carcinogenesis. Nanomedicine, including nanodiagnostics and nanotherapeutics is poised to be used in the management of vascular diseases. However, the inherent risk and potential toxicity resultant from the use of nanosized (<100 nm) materials need to be carefully considered...
May 2015: Nanomedicine
Elisabete Fernandes, José Alexandre Ferreira, Peixoto Andreia, Lima Luís, Sérgio Barroso, Bruno Sarmento, Lúcio Lara Santos
Digestive tract tumors are among the most common and deadliest malignancies worldwide, mainly due to late diagnosis and lack of efficient therapeutics. Current treatments essentially rely on surgery associated with (neo)adjuvant chemotherapy agents. Despite an upfront response, conventional drugs often fail to eliminate highly aggressive clones endowed with chemoresistant properties, which are responsible for tumor recurrence and disease dissemination. Synthetic drugs also present severe adverse systemic effects, hampering the administration of biologically effective dosages...
July 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
M Rowan Brown, Nicole Hondow, Rik Brydson, Paul Rees, Andrew P Brown, Huw D Summers
The application of nanoparticles (NPs) within medicine is of great interest; their innate physicochemical characteristics provide the potential to enhance current technology, diagnostics and therapeutics. Recently a number of NP-based diagnostic and therapeutic agents have been developed for treatment of various diseases, where judicious surface functionalization is exploited to increase efficacy of administered therapeutic dose. However, quantification of heterogeneity associated with absolute dose of a nanotherapeutic (NP number), how this is trafficked across biological barriers has proven difficult to achieve...
April 17, 2015: Nanotechnology
Hasan Turkez, Erdal Sönmez, Antonio Di Stefano, Yousef I Mokhtar
Due to their high chemical stability, lithium titanate (Li2TiO3) nanoparticles (LTT NPs) now are projected to be transferred into different nanotechnology areas like nano pharmacology and nano medicine. With the increased applications of LTT NPs for numerous purposes, the concerns about their potential human toxicity effects and their environmental impact are also increased. However, toxicity data for LTT NPs related to human health are very limited. Therefore we aimed to investigate toxicity potentials of various concentrations (0-1,000 ppm) of LTT NPs (<100 nm) in cultured primary rat hepatocytes...
March 2016: Cytotechnology
Ciprian Tomuleasa, Cornelia Braicu, Alexandra Irimie, Lucian Craciun, Ioana Berindan-Neagoe
Nanoparticles have displayed considerable promise for safely delivering therapeutic agents with miscellaneous therapeutic properties. Current progress in nanotechnology has put forward, in the last few years, several therapeutic strategies that could be integrated into clinical use by using constructs for molecular diagnosis, disease detection, cytostatic drug delivery, and nanoscale immunotherapy. In the hope of bringing the concept of nanopharmacology toward a viable and feasible clinical reality in a cancer center, the present report attempts to present the grounds for the use of cell-free nanoscale structures for molecular therapy in experimental hematology and oncology...
2014: International Journal of Nanomedicine
David Fajardo-Ortiz, Luis Duran, Laura Moreno, Héctor Ochoa, Víctor M Castaño
This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies. In the case of liposomes, our results identify subnetworks (invisible colleges) associated with different therapeutic strategies: nanopharmacology, hyperthermia, and gene therapy. Only in the pharmacological strategy was an organized knowledge translation process identified, which, however, is monopolized by the liposomal doxorubicins...
2014: International Journal of Nanomedicine
Keerti Jain, Neelesh Kumar Mehra, Narendra Kumar Jain
Nanopharmacology is a relatively newer branch of pharmacology which investigates interaction of a nanomedicine with living systems at the nanoscale level. Modern medicine is increasingly concerned with various surface modified nanocarriers, such as dendrimers, nanoparticles, carbon based nanomaterials, polymer-drug nanoconjugates, etc., which have immense therapeutic potential by target specific drug delivery, using nanoscaffolding and nanocontainers, owing to the specific physical, chemical and biological properties of these moieties that is related to their nanoscale size range...
April 2014: Current Opinion in Pharmacology
Martin Schäffler, Fernanda Sousa, Alexander Wenk, Leopoldo Sitia, Stephanie Hirn, Carsten Schleh, Nadine Haberl, Martina Violatto, Mara Canovi, Patrizia Andreozzi, Mario Salmona, Paolo Bigini, Wolfgang G Kreyling, Silke Krol
Nanoparticles (NP) and nanoparticulated drug delivery promise to be the breakthrough for therapy in medicine but raise concerns in terms of nanotoxicity. We present quantitative murine biokinetics assays using polyelectrolyte-multilayer-coated gold NP (AuNP, core diameter 15 and 80 nm; (198)Au radio-labeled). Those were stably conjugated either with human serum albumin (alb-AuNP) or apolipoprotein E (apoE-AuNP), prior to intravenous injection. We compare the biokinetics of protein-AuNP-conjugates with citrate-stabilized AuNP (cit-AuNP)...
March 2014: Biomaterials
R D Seĭfulla, E K Kim
No abstract text is available yet for this article.
2013: Eksperimental'naia i Klinicheskaia Farmakologiia
(no author information available yet)
The paper is devoted to the new direction of science - carbonology. Carbon is the base of organic compounds. Compounds of carbon with metals are known. The article gives a brief description of the three allotropic forms of carbon (soot, graphite, diamond), and various types of hybridization in organic structures, describes the role of biogenic carbon. At the end of the twentieth century new carbon nanostructures were discovered: fullerenes and carbon nanotubes. Scientists all over the world study physical, chemical, pharmacological and toxicological properties of the allotropes of carbon structures, which are promising for nanochemistry, nanopharmacology and nanotoxicology...
January 2012: Likars'ka Sprava
A K Sariev, D A Abaimov, R D Seĭfulla
Modern approaches to increasing the efficiency of liposomal transport of substances are discussed. Examples of creating new nanopharmacological drugs that exceed the pharmacokinetic characteristic of their classical analogs are given.
November 2010: Eksperimental'naia i Klinicheskaia Farmakologiia
Andrea Tinelli, Raffaele Prudenzano, Antonio Malvasi, Mario Santantonio, Vito Lorusso
INTRODUCTION: Advanced cases of uterine carcinomas with parametrial and fornix infiltration often cause massive genital bleeding, with severe anemia, fast deterioration, and a high risk of death for patients; women with advanced uterine cancer (UC) and genital massive bleeding were treated using an endovascular therapy in local anesthesia. METHODS: Ten women with advanced UC and genital massive bleeding were hospitalized for a high risk of immediate death; after blood transfusions and resuscitation therapy, the patients were submitted to an experimental nanopharmacologic endovascular therapy in local anesthesia...
October 2010: International Journal of Gynecological Cancer
Ratnesh Lal, Srinivasan Ramachandran, Morton F Arnsdorf
Nanotechnology is giving us a glimpse into a nascent field of nanopharmacology that deals with pharmacological phenomena at molecular scale. This review presents our perspective on the use of scanning probe microscopy techniques with special emphasis to multidimensional atomic force microscopy (m-AFM) to explore this new field with a particular emphasis to define targets, design therapeutics, and track outcomes of molecular-scale pharmacological interactions. The approach will be to first discuss operating principles of m-AFM and provide representative examples of studies to understand human health and disease at the molecular level and then to address different strategies in defining target macromolecules, screening potential drug candidates, developing and characterizing of drug delivery systems, and monitoring target-drug interactions...
December 2010: AAPS Journal
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