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Anna Radomska, Jarosław Leszczyszyn, Marek W Radomski
The very dynamic growth of nanotechnology, nanomaterials (sized 1-100 nm) and their medical applications over the past 10 years has promised to add a new impetus to the diagnostics and therapeutics of a wide range of human pathologies, including cancer, cardiovascular diseases and diseases of the central nervous system. This growth in nanomedicine also fuels advances in bioengineering, regenerative medicine and the development of medical devices. However, as with all new pharmaceuticals and medical devices, new opportunities are inherently accompanied by new challenges due to the ability of nanomaterials to interact with the body on the cellular, subcellular and molecular levels...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Ruiyan Zhang, Thomas Eckert, Thomas Lutteke, Stefan Hanstein, Axel Scheidig, Alexandre M J J Bonvin, Nikolay E Nifantiev, Tibor Kozar, Roland Schauer, Mushira Abdulaziz Enani, Hans-Christian Siebert
The Antimicrobial peptides (e.g. defensins, hevein-like molecules and food-protecting peptides like nisin) are able to interact specifically with contact structures on pathogen surfaces. Besides protein receptors, important recognition points for such contacts are provided by pathogen glycan chains or surface lipids. Therefore, structural data concerning surface exposed glycans and lipids are of the highest clinical interest since these recognition functions play a key role when optimising anti-infection therapies...
2016: Current Topics in Medicinal Chemistry
Krzysztof A Tomaszewski, Marek W Radomski, Maria Jose Santos-Martinez
In physiological conditions, the interactions between blood platelets and endothelial cells play a major role in vascular reactivity and hemostasis. By contrast, increased platelet activation contributes to the pathogenesis of vascular pathology such as atherosclerosis, thrombosis, diabetes mellitus, hypertension and carcinogenesis. Nanomedicine, including nanodiagnostics and nanotherapeutics is poised to be used in the management of vascular diseases. However, the inherent risk and potential toxicity resultant from the use of nanosized (<100 nm) materials need to be carefully considered...
May 2015: Nanomedicine
Elisabete Fernandes, José Alexandre Ferreira, Peixoto Andreia, Lima Luís, Sérgio Barroso, Bruno Sarmento, Lúcio Lara Santos
Digestive tract tumors are among the most common and deadliest malignancies worldwide, mainly due to late diagnosis and lack of efficient therapeutics. Current treatments essentially rely on surgery associated with (neo)adjuvant chemotherapy agents. Despite an upfront response, conventional drugs often fail to eliminate highly aggressive clones endowed with chemoresistant properties, which are responsible for tumor recurrence and disease dissemination. Synthetic drugs also present severe adverse systemic effects, hampering the administration of biologically effective dosages...
July 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
M Rowan Brown, Nicole Hondow, Rik Brydson, Paul Rees, Andrew P Brown, Huw D Summers
The application of nanoparticles (NPs) within medicine is of great interest; their innate physicochemical characteristics provide the potential to enhance current technology, diagnostics and therapeutics. Recently a number of NP-based diagnostic and therapeutic agents have been developed for treatment of various diseases, where judicious surface functionalization is exploited to increase efficacy of administered therapeutic dose. However, quantification of heterogeneity associated with absolute dose of a nanotherapeutic (NP number), how this is trafficked across biological barriers has proven difficult to achieve...
April 17, 2015: Nanotechnology
Hasan Turkez, Erdal Sönmez, Antonio Di Stefano, Yousef I Mokhtar
Due to their high chemical stability, lithium titanate (Li2TiO3) nanoparticles (LTT NPs) now are projected to be transferred into different nanotechnology areas like nano pharmacology and nano medicine. With the increased applications of LTT NPs for numerous purposes, the concerns about their potential human toxicity effects and their environmental impact are also increased. However, toxicity data for LTT NPs related to human health are very limited. Therefore we aimed to investigate toxicity potentials of various concentrations (0-1,000 ppm) of LTT NPs (<100 nm) in cultured primary rat hepatocytes...
March 2016: Cytotechnology
Ciprian Tomuleasa, Cornelia Braicu, Alexandra Irimie, Lucian Craciun, Ioana Berindan-Neagoe
Nanoparticles have displayed considerable promise for safely delivering therapeutic agents with miscellaneous therapeutic properties. Current progress in nanotechnology has put forward, in the last few years, several therapeutic strategies that could be integrated into clinical use by using constructs for molecular diagnosis, disease detection, cytostatic drug delivery, and nanoscale immunotherapy. In the hope of bringing the concept of nanopharmacology toward a viable and feasible clinical reality in a cancer center, the present report attempts to present the grounds for the use of cell-free nanoscale structures for molecular therapy in experimental hematology and oncology...
2014: International Journal of Nanomedicine
David Fajardo-Ortiz, Luis Duran, Laura Moreno, Héctor Ochoa, Víctor M Castaño
This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies. In the case of liposomes, our results identify subnetworks (invisible colleges) associated with different therapeutic strategies: nanopharmacology, hyperthermia, and gene therapy. Only in the pharmacological strategy was an organized knowledge translation process identified, which, however, is monopolized by the liposomal doxorubicins...
2014: International Journal of Nanomedicine
Keerti Jain, Neelesh Kumar Mehra, Narendra Kumar Jain
Nanopharmacology is a relatively newer branch of pharmacology which investigates interaction of a nanomedicine with living systems at the nanoscale level. Modern medicine is increasingly concerned with various surface modified nanocarriers, such as dendrimers, nanoparticles, carbon based nanomaterials, polymer-drug nanoconjugates, etc., which have immense therapeutic potential by target specific drug delivery, using nanoscaffolding and nanocontainers, owing to the specific physical, chemical and biological properties of these moieties that is related to their nanoscale size range...
April 2014: Current Opinion in Pharmacology
Martin Schäffler, Fernanda Sousa, Alexander Wenk, Leopoldo Sitia, Stephanie Hirn, Carsten Schleh, Nadine Haberl, Martina Violatto, Mara Canovi, Patrizia Andreozzi, Mario Salmona, Paolo Bigini, Wolfgang G Kreyling, Silke Krol
Nanoparticles (NP) and nanoparticulated drug delivery promise to be the breakthrough for therapy in medicine but raise concerns in terms of nanotoxicity. We present quantitative murine biokinetics assays using polyelectrolyte-multilayer-coated gold NP (AuNP, core diameter 15 and 80 nm; (198)Au radio-labeled). Those were stably conjugated either with human serum albumin (alb-AuNP) or apolipoprotein E (apoE-AuNP), prior to intravenous injection. We compare the biokinetics of protein-AuNP-conjugates with citrate-stabilized AuNP (cit-AuNP)...
March 2014: Biomaterials
R D Seĭfulla, E K Kim
No abstract text is available yet for this article.
2013: Eksperimental'naia i Klinicheskaia Farmakologiia
(no author information available yet)
The paper is devoted to the new direction of science - carbonology. Carbon is the base of organic compounds. Compounds of carbon with metals are known. The article gives a brief description of the three allotropic forms of carbon (soot, graphite, diamond), and various types of hybridization in organic structures, describes the role of biogenic carbon. At the end of the twentieth century new carbon nanostructures were discovered: fullerenes and carbon nanotubes. Scientists all over the world study physical, chemical, pharmacological and toxicological properties of the allotropes of carbon structures, which are promising for nanochemistry, nanopharmacology and nanotoxicology...
January 2012: Likars'ka Sprava
A K Sariev, D A Abaimov, R D Seĭfulla
Modern approaches to increasing the efficiency of liposomal transport of substances are discussed. Examples of creating new nanopharmacological drugs that exceed the pharmacokinetic characteristic of their classical analogs are given.
November 2010: Eksperimental'naia i Klinicheskaia Farmakologiia
Andrea Tinelli, Raffaele Prudenzano, Antonio Malvasi, Mario Santantonio, Vito Lorusso
INTRODUCTION: Advanced cases of uterine carcinomas with parametrial and fornix infiltration often cause massive genital bleeding, with severe anemia, fast deterioration, and a high risk of death for patients; women with advanced uterine cancer (UC) and genital massive bleeding were treated using an endovascular therapy in local anesthesia. METHODS: Ten women with advanced UC and genital massive bleeding were hospitalized for a high risk of immediate death; after blood transfusions and resuscitation therapy, the patients were submitted to an experimental nanopharmacologic endovascular therapy in local anesthesia...
October 2010: International Journal of Gynecological Cancer
Ratnesh Lal, Srinivasan Ramachandran, Morton F Arnsdorf
Nanotechnology is giving us a glimpse into a nascent field of nanopharmacology that deals with pharmacological phenomena at molecular scale. This review presents our perspective on the use of scanning probe microscopy techniques with special emphasis to multidimensional atomic force microscopy (m-AFM) to explore this new field with a particular emphasis to define targets, design therapeutics, and track outcomes of molecular-scale pharmacological interactions. The approach will be to first discuss operating principles of m-AFM and provide representative examples of studies to understand human health and disease at the molecular level and then to address different strategies in defining target macromolecules, screening potential drug candidates, developing and characterizing of drug delivery systems, and monitoring target-drug interactions...
December 2010: AAPS Journal
Madaswamy S Muthu, Si-Shen Feng
No abstract text is available yet for this article.
September 2010: Nanomedicine
R D Seĭfulla
No abstract text is available yet for this article.
July 2010: Eksperimental'naia i Klinicheskaia Farmakologiia
L B Piotrovskiĭ
In the general sense, nanomedicine is defined as the application of nanotechnologies including nanobiothechnologies in medicine. Under conditions of current rapid development of nanotechnologies, many terms and definitions lack clarity and precision and boundaries between traditional and nanotechnologies are equally poorly determined. Evidently, dimensional parameters alone are insufficient to refer someone or other work to the field of nanotechnology (e.g., nanomedicine). Fundamental novelty of nanomedicine as a branch of knowledge and technology is exemplified by the developments in pharmacology and design of medicinal products that brought about new nanomedical (nanopharmacological, nanopharmaceutical) drugs...
2010: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Patricia O'Malley
No abstract text is available yet for this article.
May 2010: Clinical Nurse Specialist CNS
I S Chekman
A new trend of scientific-technical and medical researches has been formed which unites nanoscience, nanotechnology, nanomedicine, nanopharmacology. Nanoparticles are the main product of nanotechnologies. Nanoparticles are organic and inorganic structures, their size being less than one hundred nanometers (nano from Greece nanos--a dwarf; particle is a separate unit which is separated from the whole). Prefix nano means 10(-9) m. Nanosizes are values from 1 to 100 nanometers, micro-sizes--from 100 to 1000 nanometers, and above 1000 nanometers--are macrosizes...
January 2009: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
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