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Mylin torres

Canhua Xiao, Andrew H Miller, Jennifer Felger, Donna Mister, Tian Liu, Mylin A Torres
PURPOSE/OBJECTIVE: The purpose of this study was to examine the impact of radiotherapy on quality of life (QOL) of breast cancer patients during and until 1 year post radiotherapy treatment. METHODS AND MATERIALS: Thirty-nine breast cancer patients treated with breast conserving surgery were enrolled in a prospective study prior to whole breast radiotherapy (50 Gy plus a 10 Gy boost). No patient received chemotherapy. Data were collected before, at week 6 of radiotherapy, 6 weeks, and 1 year post-radiotherapy...
January 2016: Advances in Radiation Oncology
Bree R Eaton, Renjian Jiang, Mylin A Torres, Shannon T Kahn, Karen Godette, Timothy L Lash, Kevin C Ward
BACKGROUND: The purpose of the current study was to evaluate the impact of radiotherapy (RT) among women aged ≥ 70 years with T1-2N0 estrogen receptor (ER)-negative breast cancer using Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked data. METHODS: The study included 3432 women, 2850 of whom received and 582 of whom did not receive RT after breast-conserving surgery. Outcomes were estimated by the cumulative incidence method and compared with the Gray test...
October 2016: Cancer
Mylin A Torres, Xiaofeng Yang, Samantha Noreen, Hao Chen, Tatiana Han, Simone Henry, Donna Mister, Fundagal Andic, Qi Long, Tian Liu
PURPOSE: This prospective study was conducted to determine predictors of epidermal thickening during and after whole-breast radiation therapy (XRT) using objective measurements acquired with ultrasound. METHODS AND MATERIALS: After breast-conserving surgery, 70 women received a definitive course of whole-breast XRT (50 Gy plus boost). Prior to XRT, at week 6 of XRT, and 6 weeks after XRT, patients underwent objective ultrasound measurements of epidermal thickness over the lumpectomy cavity and all 4 quadrants of the treated breast...
June 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Hui Zhang, PamelaSara E Head, Waaqo Daddacha, Seong-Hoon Park, Xingzhe Li, Yunfeng Pan, Matthew Z Madden, Duc M Duong, Maohua Xie, Bing Yu, Matthew D Warren, Elaine A Liu, Vishal R Dhere, Chunyang Li, Ivan Pradilla, Mylin A Torres, Ya Wang, William S Dynan, Paul W Doetsch, Xingming Deng, Nicholas T Seyfried, David Gius, David S Yu
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear. We found that deacetylation of ATR-interacting protein (ATRIP), a regulatory partner of ATR, by SIRT2 potentiates the ATR checkpoint. SIRT2 interacts with and deacetylates ATRIP at lysine 32 (K32) in response to replication stress. SIRT2 deacetylation of ATRIP at K32 drives ATR autophosphorylation and signaling and facilitates DNA replication fork progression and recovery of stalled replication forks...
February 16, 2016: Cell Reports
Shravan Kandula, Jeffrey M Switchenko, Saul Harari, Carolina Fasola, Donna Mister, David S Yu, Amelia B Zelnak, Mylin A Torres
Among breast cancer patients treated with neoadjuvant chemotherapy (NAC) and mastectomy, locoregional recurrence (LRR) rates are unclear in women with ER+ tumors treated with adjuvant endocrine therapy without postmastectomy radiation (PMRT). To determine if PMRT is needed in these patients, we compared LRR rates of patients with ER+ tumors (treated with adjuvant endocrine therapy) with women who have non-ER+ tumors. 85 consecutive breast cancer patients (87 breast tumors) treated with NAC and mastectomy without PMRT were reviewed...
2015: International Journal of Breast Cancer
Tatiana J Han, Jennifer C Felger, Anna Lee, Donna Mister, Andrew H Miller, Mylin A Torres
BACKGROUND: This pilot study examined whether breast cancer patients with childhood trauma exhibit increased fatigue, depression, and stress in association with inflammation as a result of whole breast radiotherapy (RT). METHODS: Twenty breast cancer patients were enrolled in a prospective, longitudinal study of fatigue, depression, and perceived stress prior to RT, week 6 of RT, and 6 weeks post-RT. Six weeks after RT, subjects completed the childhood trauma questionnaire (CTQ)...
February 2016: Psycho-oncology
Soumon Rudra, David S Yu, Esther S Yu, Jeffrey M Switchenko, Donna Mister, Mylin A Torres
Objective. This study examined recurrence patterns in breast cancer patients younger than age of 40 and older than age of 75, two groups that are underrepresented in clinical trials and not routinely screened by mammography. Methods. The records of 230 breast cancer patients (n = 125 less than 40 and n = 105 greater than 75) who presented to the Emory University Department of Radiation Oncology for curative treatment between 1997 and 2010 were reviewed. Data recorded included disease presentation, treatment, and areas of locoregional recurrence...
2015: International Journal of Breast Cancer
Naresh K Jegadeesh, Sunjin Kim, Roshan S Prabhu, Gabriela M Oprea, David S Yu, Karen G Godette, Amelia B Zelnak, Donna Mister, Jeffrey M Switchenko, Mylin A Torres
PURPOSE: Although the 21-gene recurrence score (RS) assay has been validated to assess the risk of distant recurrence in hormone receptor-positive breast cancer patients, the relationship between RS and the risk of locoregional recurrence (LRR) remains unclear. The purpose of this study was to determine if RS is associated with LRR in breast cancer patients and whether this relationship varies based on the type of local treatment [mastectomy or breast-conserving therapy (BCT)]. METHODS: 163 consecutive estrogen receptor-positive breast cancer patients at our institution had an RS generated from the primary breast tumor between August 2006 and October 2009...
April 2015: Annals of Surgical Oncology
Scott C Smith, Aleksandra V Petrova, Matthew Z Madden, Hongyan Wang, Yunfeng Pan, Matthew D Warren, Claire W Hardy, Dong Liang, Elaine A Liu, M Hope Robinson, Soumon Rudra, Jie Wang, Shahrzad Ehdaivand, Mylin A Torres, Ya Wang, David S Yu
The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucleoside analogue that causes cytotoxicity by inducing DNA replication blocks. Using a synthetic lethal screen of a RNAi library of nuclear enzymes to identify genes that when silenced cause gemcitabine sensitization or resistance in human triple-negative breast cancer cells, we identified NIMA (never in mitosis gene A)-related kinase 9 (NEK9) as a key component of the RSR...
October 2014: Nucleic Acids Research
Amelia B Zelnak, Petros Nikolinakos, Jayanthi Srinivasiah, William Jonas, Andrew Pippas, Yuan Liu, Xiaoxian Li, Mylin Torres, Ruth M O'Regan
BACKGROUND: Neoadjuvant chemotherapy is widely used to downstage breast cancers before surgery and is an accepted standard of care among patients with early-stage breast cancer in whom adjuvant chemotherapy would be recommended. Pathologic complete response (pCR) rate is a robust predictor of outcome for certain breast cancer subtypes, including Her2-overexpressing breast cancer. The incorporation of Her2-targeted therapies has significantly increased the pCR rate in the neoadjuvant setting...
February 2015: Clinical Breast Cancer
Alicia K Smith, Karen N Conneely, Thaddeus W W Pace, Donna Mister, Jennifer C Felger, Varun Kilaru, Mary J Akel, Paula M Vertino, Andrew H Miller, Mylin A Torres
Inflammation has been associated with fatigue during and after various types of breast cancer treatments. We examined whether prior chemotherapy was associated with DNA methylation patterns that could explain persisting inflammation and/or fatigue in women treated for breast cancer. Prior to breast radiation therapy, DNA was extracted from peripheral blood mononuclear cells (PBMCs) of 61 Stage 0-IIIA breast cancer patients who had received partial mastectomy with or without chemotherapy. DNA methylation was assessed at >485,000 CpG sites across the genome along with fatigue and plasma inflammatory markers previously associated with fatigue...
May 2014: Brain, Behavior, and Immunity
David M Marcus, Jeffrey M Switchenko, Roshan Prabhu, Ruth O'Regan, Amelia Zelnak, Carolina Fasola, Donna Mister, Mylin A Torres
OBJECTIVES: We compared outcomes in post-menopausal estrogen receptor-positive (ER+) breast cancer patients treated with neoadjuvant hormonal therapy (NAHT) or neoadjuvant chemotherapy (NACT). METHODS: We retrospectively identified post-menopausal women who received either NAHT or NACT for non-metastatic, non-inflammatory, ER+, Her2neu negative breast cancer from 2004 to 2011. We compared long-term rates of locoregional relapse free survival (LRFS), distant metastasis free survival (DMFS), and overall survival (OS) using the Kaplan-Meier method...
2013: Frontiers in Oncology
Bree R Eaton, Albert Losken, Derick Okwan-Duodu, David M Schuster, Jeffrey M Switchenko, Donna Mister, Karen Godette, Mylin A Torres
BACKGROUND: The purpose of this study was to describe the incidence and location of ipsilateral breast tumor recurrence (IBTR) among breast cancer patients treated with oncoplastic reduction mammoplasty (ORM) and radiotherapy (RT). METHODS: The medical records of 86 consecutive women with ductal carcinoma in situ (DCIS) (n = 11) or invasive carcinoma of the breast (n = 75) treated with ORM at Emory University between January 1994 and December 2010 were reviewed...
January 2014: Annals of Surgical Oncology
Yi Gao, Allen Tannenbaum, Hao Chen, Mylin Torres, Emi Yoshida, Xiaofeng Yang, Yuefeng Wang, Walter Curran, Tian Liu
Skin toxicity is the most common side effect of breast cancer radiotherapy and impairs the quality of life of many breast cancer survivors. We, along with other researchers, have recently found quantitative ultrasound to be effective as a skin toxicity assessment tool. Although more reliable than standard clinical evaluations (visual observation and palpation), the current procedure for ultrasound-based skin toxicity measurements requires manual delineation of the skin layers (i.e., epidermis-dermis and dermis-hypodermis interfaces) on each ultrasound B-mode image...
November 2013: Ultrasound in Medicine & Biology
Mylin A Torres, Thaddeus W Pace, Tian Liu, Jennifer C Felger, Donna Mister, Gregory H Doho, Jordan N Kohn, Andrea M Barsevick, Qi Long, Andrew H Miller
BACKGROUND: Depression is common during and after breast cancer treatment. However, the role of specific therapeutic modalities and related biologic mechanisms remains unclear. Radiation is an essential component of breast-conserving therapy and may contribute to depression in patients with breast cancer through the activation of inflammatory pathways. METHODS: Depressive symptoms and inflammatory mediators, including nuclear factor kappa B (NF-κB), were assessed at baseline (before radiation), during radiation, and 6 weeks after radiation in 64 women who had stage 0 through IIIA breast cancer...
June 1, 2013: Cancer
Susie A Chen, Crispin Hiley, Dana Nickleach, Janjira Petsuksiri, Fundagul Andic, Oliver Riesterer, Jeffrey M Switchenko, Mylin A Torres
PURPOSE: The goal of this study was to explore the perspectives and practice of radiation oncologists who treat breast cancer patients who have had breast reconstruction. METHODS: In 2010, an original electronic survey was sent to all physician members of the American Society of Radiation Oncology, National Cancer Research Institute-Breast Cancer Studies Group in the United Kingdom, Thai Society of Therapeutic Radiology and Oncology, Swiss Society of Radiation Oncology, and Turkish Radiation Oncology Society...
2013: Radiation Oncology
Susie A Chen, David M Schuster, Donna Mister, Tian Liu, Karen Godette, Mylin A Torres
PURPOSE: Locoregional control is associated with breast cancer-specific and overall survival in select women with breast cancer. Although several patient, tumor, and treatment characteristics have been shown to contribute to locoregional recurrence (LRR), studies evaluating factors related to radiotherapy (XRT) technique have been limited. We investigated the relationship between LRR location and XRT fields and dose delivered to the primary breast cancer in women experiencing subsequent locoregional relapse...
February 1, 2013: International Journal of Radiation Oncology, Biology, Physics
Susie A Chen, Tomiwa Ogunleye, Anees Dhabbaan, Eugene H Huang, Albert Losken, Sheryl Gabram, Lawrence Davis, Mylin A Torres
PURPOSE: Temporary tissue expanders (TTE) with an internal magnetic metal port (IMP) have been increasingly used for breast reconstruction in post-mastectomy patients who receive radiation therapy (XRT). We evaluated XRT plans of patients with IMP to determine its effect on XRT dose distribution. METHODS AND MATERIALS: Original treatment plans with CT simulation scans of 24 consecutive patients who received XRT (ORI), planned without heterogeneity corrections, to a reconstructed breast containing an IMP were used...
March 1, 2013: International Journal of Radiation Oncology, Biology, Physics
Sharla Gayle Patterson, Paige Teller, Radha Iyengar, Grant W Carlson, Sheryl G A Gabram-Mendola, Albert Losken, Toncred Styblo, Mylin Torres, William C Wood, Sebastian D Perez, Marina Mosunjac, Monica Rizzo
BACKGROUND: The locoregional recurrence (LRR) rate after mastectomy is reported to be similar with immediate reconstruction. We aimed to identify characteristics of LRR after transverse rectus abdominis myocutaneous (TRAM) reconstruction. METHODS: We retrospectively reviewed patients undergoing immediate TRAM reconstruction for breast cancer who were diagnosed with LRR. RESULTS: We identified 18 LRR (4.6 %) in 18 of 390 patients who underwent immediate TRAM reconstructions for breast cancer from 1998 to 2008...
August 2012: Annals of Surgical Oncology
Roshan Prabhu, Karen Godette, Grant Carlson, Albert Losken, Sheryl Gabram, Carolina Fasola, Ruth O'Regan, Amelia Zelnak, Mylin Torres
PURPOSE: The safety and efficacy of skin-sparing mastectomy (SSM) with immediate reconstruction (IR) in patients with locally advanced breast cancer are unclear. The purpose of this study is to compare the outcomes of women with noninflammatory Stage III SSM with IR vs. non-SSM-treated women who underwent neoadjuvant chemotherapy and adjuvant radiation therapy (XRT). METHODS AND MATERIALS: Between October 1997 and March 2010, 100 consecutive patients (40 SSM with IR vs...
March 15, 2012: International Journal of Radiation Oncology, Biology, Physics
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