keyword
https://read.qxmd.com/read/37621676/redlining-associated-methylation-in-breast-tumors-the-impact-of-contemporary-structural-racism-on-the-tumor-epigenome
#1
JOURNAL ARTICLE
Jasmine M Miller-Kleinhenz, Leah Moubadder, Kirsten M Beyer, Yuhong Zhou, Anne H Gaglioti, Lindsay J Collin, Jazib Gohar, Whitney Do, Karen Conneely, Uma Krishnamurti, Keerthi Gogineni, Sheryl Gabram-Mendola, Olivia D'Angelo, Kashari Henry, Mylin Torres, Lauren E McCullough
PURPOSE: Place-based measures of structural racism have been associated with breast cancer mortality, which may be driven, in part, by epigenetic perturbations. We examined the association between contemporary redlining, a measure of structural racism at the neighborhood level, and DNA methylation in breast tumor tissue. METHODS: We identified 80 Black and White women diagnosed and treated for a first-primary breast cancer at Emory University Hospitals (2008-2017)...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37179080/asian-american-and-pacific-islander-female-faculty-and-the-double-whammy
#2
EDITORIAL
Mylin A Torres
No abstract text is available yet for this article.
June 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/36892508/prolonging-the-life-of-people-with-metastatic-breast-cancer-in-routine-clinical-practice-by-adding-palbociclib-to-an-aromatase-inhibitor-from-a-real-world-database-analysis-a-plain-language-summary
#3
REVIEW
Hope S Rugo, Adam Brufsky, Xianchen Liu, Benjamin Li, Lynn McRoy, Connie Chen, Rachel M Layman, Massimo Cristofanilli, Mylin A Torres, Giuseppe Curigliano, Richard S Finn, Angela DeMichele
WHAT IS THIS SUMMARY ABOUT?: This is a summary of an article about a study called "P-REALITY X" that was published in the medical journal npj Breast Cancer in October 2022. "P-REALITY X" stands for Palbociclib REAl-world first-LIne comparaTive effectiveness studY eXtended. This study used information from a database to look at whether adding a second treatment (palbociclib) to an aromatase inhibitor (AI) helped people with a certain type of breast cancer to live longer. The type of breast cancer is metastatic hormone receptor-positive/human epidermal growth factor-negative breast cancer, also called HR-positive (or HR+)/HER2-negative (or HER2-) breast cancer...
March 2023: Future Oncology
https://read.qxmd.com/read/36728139/a-discordant-pattern-of-uptake-on-68ga-psma-pet-ct-versus-18f-fluciclovine-pet-ct-in-radiation-induced-hepatitis-implications-for-early-postradiotherapy-imaging-based-response-assessment
#4
JOURNAL ARTICLE
Omotayo A Adediran, Ismaheel O Lawal, Saima Muzahir, Manali A Bhave, Sarah Friend, Bridget Fielder, Jane Meisel, Mylin A Torres, Toncred M Styblo, Cathy Graham, Anna Holbrook, Kevin Kalinsky, Ronald J Crowe, Gary A Ulaner, David M Schuster
A 62-year-old woman with right-sided invasive lobular breast carcinoma completed external beam radiotherapy 6 weeks before undergoing a 68Ga-PSMA PET/CT and 18F-fluciclovine PET/CT scan as part of an ongoing clinical trial (NCT04750473) assessing the performance of these molecular imaging modalities in invasive lobular breast carcinoma. The 68Ga-PSMA PET/CT demonstrated a band-like area of increased radiotracer uptake in the dome of the right lobe of the liver anteriorly, whereas 18F-fluciclovine PET/CT done a day later revealed photopenia in the corresponding area of the liver...
January 13, 2023: Clinical Nuclear Medicine
https://read.qxmd.com/read/36603181/polarized-risk-for-local-recurrence-on-the-basis-of-tumor-biology-is-it-that-simple
#5
EDITORIAL
Mylin A Torres
No abstract text is available yet for this article.
January 5, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/36583524/ultrasound-based-grading-system-for-radiation-induced-acute-breast-toxicity
#6
JOURNAL ARTICLE
Jing Wang, Boran Zhou, Xiaofeng Yang, Srini Tridandapani, Jolinta Lin, Mylin A Torres, Tian Liu
OBJECTIVES: To introduce an ultrasound-based scoring system for radiation-induced breast toxicity and test its reliability. METHODS: Breast ultrasound (BUS) was performed on 32 patients receiving breast radiotherapy (RT) to assess the radiation-induced acute toxicity. For each patient, both the untreated and irradiated breasts were scanned at five locations: 12:00, 3:00, 6:00, 9:00, and tumor bed to evaluate for heterogenous responses to radiation within the entire breast...
December 30, 2022: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/36469077/a-tale-of-3-tracers-contrasting-uptake-patterns-of-18f-fluciclovine-68ga-psma-and-18f-fdg-in-the-uterus-and-adnexa
#7
JOURNAL ARTICLE
Ismaheel O Lawal, Omotayo Atinuke Adediran, Saima Muzahir, Sarah Friend, Manali Ajay Bhave, Jane Meisel, Mylin A Torres, Toncred Marya Styblo, Cathy Graham, Anna Holbrook, Kevin Kalinsky, Bridget Fielder, Ronald J Crowe, Gary A Ulaner, David M Schuster
A 41-year-old woman with invasive lobular carcinoma of the breast underwent sequential 68Ga-PSMA-11 PET/CT and 18F-fluciclovine PET/CT as part of an ongoing clinical trial (NCT04750473). 68Ga-PSMA PET/CT showed increased radiotracer uptake in the uterine endometrium and left adnexa. 18F-fluciclovine PET/CT showed increased radiotracer uptake in a leiomyomatous uterus. A clinical 18F-FDG PET/CT demonstrated radiotracer uptake in the endometrium and a circumferential area of uptake in the left adnexa, a pattern more similar to the 68Ga-PSMA uptake pattern...
January 1, 2023: Clinical Nuclear Medicine
https://read.qxmd.com/read/36441032/ultrasound-histogram-assessment-of-acute-breast-toxicity-after-breast-cancer-radiation-therapy-a-prospective-longitudinal-study
#8
JOURNAL ARTICLE
Boran Zhou, Jing Wang, Xiaofeng Yang, Simone Henry, Jolinta Y Lin, Mylin A Torres, Tian Liu
Accurate assessment of radiation-induced breast toxicity is crucial for the management of breast radiation therapy (RT). Standard assessment of breast toxicity based on clinicians' visual inspection and palpation has considerable inter- and intra-observer variability. To overcome this challenge, we present an ultrasound histogram method that objectively evaluates radiation-induced breast toxicity longitudinally. In a prospective study, patients enrolled (n = 67) received ultrasound scans at four time points: prior to RT, last day of RT, 3-4 wk post-RT and 9-12-wk post-RT...
January 2023: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/36333193/racial-disparities-in-clinical-outcomes-on-investigator-initiated-breast-cancer-clinical-trials-at-an-urban-medical-center
#9
JOURNAL ARTICLE
Jeffrey Aldrich, Princess Ekpo, Manali Rupji, Jeffrey M Switchenko, Mylin A Torres, Kevin Kalinsky, Manali A Bhave
BACKGROUND: Black women are 40% more likely to die of breast cancer compared to White women. Inadequate representation of Black patients in clinical trials may contribute to health care inequity. We aimed to assess breast cancer clinical outcomes in Non-Hispanic Black (Black) versus Non-Hispanic White (White) women with metastatic breast cancer (MBC) enrolled on investigator-initiated clinical trials at Winship Cancer Institute at Emory University, given the significant number of patients from underrepresented minority groups seen at Winship...
October 13, 2022: Clinical Breast Cancer
https://read.qxmd.com/read/36220852/real-world-study-of-overall-survival-with-palbociclib-plus-aromatase-inhibitor-in-hr-her2-metastatic-breast-cancer
#10
JOURNAL ARTICLE
Hope S Rugo, Adam Brufsky, Xianchen Liu, Benjamin Li, Lynn McRoy, Connie Chen, Rachel M Layman, Massimo Cristofanilli, Mylin A Torres, Giuseppe Curigliano, Richard S Finn, Angela DeMichele
Data on real-world effectiveness of cyclin-dependent kinase 4/6 inhibitor combination therapy versus endocrine therapy alone are limited. The Flatiron Health Analytic Database was used to assess overall survival (OS) in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer (MBC) treated with first-line palbociclib plus an aromatase inhibitor (AI) versus an AI alone in routine US clinical practice. In total, 2888 patients initiated treatment during February 3, 2015-March 31, 2020, with a potential ≥6-month follow-up (cutoff date, September 30, 2020)...
October 11, 2022: NPJ Breast Cancer
https://read.qxmd.com/read/36115740/a-novel-biosignature-identifies-patients-with-dcis-with-high-risk-of-local-recurrence-after-breast-conserving-surgery-and-radiation-therapy
#11
JOURNAL ARTICLE
Frank A Vicini, G Bruce Mann, Chirag Shah, Sheila Weinmann, Michael C Leo, Pat Whitworth, Rachel Rabinovitch, Mylin A Torres, Julie A Margenthaler, David Dabbs, Jess Savala, Steven C Shivers, Karuna Mittal, Fredrik Wärnberg, Troy Bremer
PURPOSE: There is an unmet need to identify women diagnosed with ductal carcinoma in situ (DCIS) with a low risk of in-breast recurrence (IBR) after breast conserving surgery (BCS), which could omit radiation therapy (RT), and also to identify those with elevated IBR risk remaining after BCS plus RT. We evaluated a novel biosignature for a residual risk subtype (RRt) to help identify patients with elevated IBR risk after BCS plus RT. METHODS AND MATERIALS: Women with DCIS treated with BCS with or without RT at centers in the US, Australia, and Sweden (n = 926) were evaluated...
January 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/35628139/exosomal-metabolic-signatures-are-associated-with-differential-response-to-neoadjuvant-chemotherapy-in-patients-with-breast-cancer
#12
JOURNAL ARTICLE
Shriya Joshi, Chakravarthy Garlapati, Shristi Bhattarai, Yixin Su, Leslimar Rios-Colon, Gagan Deep, Mylin A Torres, Ritu Aneja
Neoadjuvant chemotherapy (NAC) is commonly used in breast cancer (BC) patients to increase eligibility for breast-conserving surgery. Only 30% of patients with BC show pathologic complete response (pCR) after NAC, and residual disease (RD) is associated with poor long-term prognosis. A critical barrier to improving NAC outcomes in patients with BC is the limited understanding of the mechanisms underlying differential treatment outcomes. In this study, we evaluated the ability of exosomal metabolic profiles to predict NAC response in patients with BC...
May 10, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35504910/dna-methylation-signature-of-chronic-low-grade-inflammation-and-its-role-in-cardio-respiratory-diseases
#13
JOURNAL ARTICLE
Matthias Wielscher, Pooja R Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M Psaty, Marie Loh, Joshua C Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J Deary, Marc Chadeau-Hyam, Jennifer A Brody, Alexia Cardona, Elizabeth Selvin, Alicia K Smith, Andrew H Miller, Mylin A Torres, Eirini Marouli, Xin Gào, Joyce B J van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao Zhang, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A Hurme, Olli T Raitakari, Elena Colicino, Andrea A Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, Karen N Conneely, Jaspal S Kooner, Anna Köttgen, Bastiaan T Heijmans, Panos Deloukas, Caroline Relton, Ken K Ong, Jordana T Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C Chambers, Abbas Dehghan, Marjo-Riitta Järvelin
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions...
May 3, 2022: Nature Communications
https://read.qxmd.com/read/35015068/race-ethnicity-and-sex-among-senior-faculty-in-radiation-oncology-from-2000-to-2019
#14
JOURNAL ARTICLE
James R Janopaul-Naylor, Sanford E Roberts, Hui-Kuo Shu, Aparna H Kesarwala, Jolinta Y Lin, Jeffrey M Switchenko, Mylin A Torres
No abstract text is available yet for this article.
January 4, 2022: JAMA Network Open
https://read.qxmd.com/read/34978015/neighborhood-characteristics-and-breast-tumor-methylation-using-epigenomics-to-explore-cancer-outcome-disparities
#15
JOURNAL ARTICLE
Jazib Gohar, Whitney L Do, Jasmine Miller-Kleinhenz, Karen Conneely, Uma Krishnamurti, Olivia D'Angelo, Keerthi Gogineni, Mylin Torres, Sheryl Gabram-Mendola, Lauren E McCullough
BACKGROUND: Social exposures may drive epigenetic alterations that affect racial disparities in breast cancer outcomes. This study examined the association between neighborhood-level factors and DNA methylation in non-Hispanic Black and White women diagnosed with breast cancer. METHODS: Genome-wide DNA methylation was measured using the EPIC array in the tumor tissue of 96 women. Linear regression models were used to examine the association between nine neighborhood-level factors and methylation, regressing β values for each cytosine-phosphate guanine dinucleotide (CpG) site on neighborhood-level factors while adjusting for covariates...
January 3, 2022: Breast Cancer Research and Treatment
https://read.qxmd.com/read/34399407/receipt-of-guideline-concordant-care-does-not-explain-breast-cancer-mortality-disparities-by-race-in-metropolitan-atlanta
#16
JOURNAL ARTICLE
Lindsay J Collin, Ming Yan, Renjian Jiang, Keerthi Gogineni, Preeti Subhedar, Kevin C Ward, Jeffrey M Switchenko, Joseph Lipscomb, Jasmine Miller-Kleinhenz, Mylin A Torres, Jolinta Lin, Lauren E McCullough
BACKGROUND: Racial disparities in breast cancer mortality in the United States are well documented. Non-Hispanic Black (NHB) women are more likely to die of their disease than their non-Hispanic White (NHW) counterparts. The disparity is most pronounced among women diagnosed with prognostically favorable tumors, which may result in part from variations in their receipt of guideline care. In this study, we sought to estimate the effect of guideline-concordant care (GCC) on prognosis, and to evaluate whether receipt of GCC modified racial disparities in breast cancer mortality...
August 16, 2021: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/34229943/regional-nodal-irradiation-for-clinically-node-positive-breast-cancer-patients-with-pathologic-negative-nodes-after-neoadjuvant-chemotherapy
#17
JOURNAL ARTICLE
Ashley Schlafstein, Yuan Liu, Subir Goyal, Shannon Kahn, Karen Godette, Jolinta Lin, Mylin A Torres, Trevor J Royce, Sagar A Patel
INTRODUCTION: Neoadjuvant chemotherapy (NAC) is increasingly used for operable breast cancer (BC). Appropriate radiation therapy (RT) fields (ie, whole breast [WB] ± regional nodal irradiation [RNI]) in patients who were clinically node positive (cN1) but convert to pathologically node negative (ypN0) after NAC are unknown and the subject of the accruing NSABP B-51 trial. We sought to compare outcomes between WB RT with or without RNI following breast conservation and sentinel lymph node biopsy (SLNB) alone in cN1, ypN0 women following NAC...
February 2022: Clinical Breast Cancer
https://read.qxmd.com/read/33761995/comparative-effectiveness-of-first-line-palbociclib-plus-letrozole-versus-letrozole-alone-for-hr-her2-metastatic-breast-cancer-in-us-real-world-clinical-practice
#18
COMPARATIVE STUDY
Angela DeMichele, Massimo Cristofanilli, Adam Brufsky, Xianchen Liu, Jack Mardekian, Lynn McRoy, Rachel M Layman, Birol Emir, Mylin A Torres, Hope S Rugo, Richard S Finn
BACKGROUND: Findings from randomized clinical trials may have limited generalizability to patients treated in routine clinical practice. This study examined the effectiveness of first-line palbociclib plus letrozole versus letrozole alone on survival outcomes in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor-negative (HER2-) metastatic breast cancer (MBC) treated in routine clinical practice in the USA. PATIENTS AND METHODS: This was a retrospective observational analysis of electronic health records within the Flatiron Health Analytic Database...
March 24, 2021: Breast Cancer Research: BCR
https://read.qxmd.com/read/32665190/the-influence-of-histologic-grade-on-outcomes-of-elderly-women-with-early-stage-breast-cancer-treated-with-breast-conserving-surgery-with-or-without-radiotherapy
#19
JOURNAL ARTICLE
Chase E Escott, David Zaenger, Jeffrey M Switchencko, Jolinta Y Lin, Mustafa Abugideiri, Cletus A Arciero, Neil T Pfister, Karen M Xu, Jane L Meisel, Preeti Subhedar, Mylin Torres, Walter J Curran, Pretesh R Patel
BACKGROUND: Two large randomized trials, CALGB 9343 and PRIME II, support omission of radiotherapy after breast conserving surgery (BCS) in elderly women with favorable-risk early stage breast cancer intending to take endocrine therapy. However, patients with grade 3 histology were underrepresented on these trials. We hypothesized that high-grade disease may be unsuitable for treatment de-escalation and report the oncologic outcomes for elderly women with favorable early stage breast cancer treated with BCS with or without radiotherapy...
December 2020: Clinical Breast Cancer
https://read.qxmd.com/read/32442076/postmastectomy-and-regional-nodal-radiation-for-breast-cancer
#20
REVIEW
Mylin A Torres, Kathleen C Horst, Gary M Freedman
No abstract text is available yet for this article.
July 10, 2020: Journal of Clinical Oncology
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