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Polyunsaturated Fat

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https://www.readbyqxmd.com/read/27935525/association-of-dietary-protein-and-dairy-intakes-and-change-in-renal-function-results-from-the-population-based-longitudinal-doetinchem-cohort-study
#1
Gerrie-Cor M Herber-Gast, Sander Biesbroek, Wm Monique Verschuren, Coen DA Stehouwer, Ron T Gansevoort, Stephan Jl Bakker, Annemieke Mw Spijkerman
BACKGROUND: Evidence has suggested that protein from dairy may be less detrimental to renal health than protein from nondairy products. However, to our knowledge, no previous studies have used cystatin C-based measures of the estimated glomerular filtration rate (eGFR). OBJECTIVE: We investigated the associations of sources of protein and dairy with the change in the eGFR in persons with a normal or mildly decreased eGFR. DESIGN: We included 3798 participants, aged 26-65 y, from the Doetinchem Cohort study who were examined ≥3 times 5 y apart...
December 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27931137/impact-of-olive-oil-rich-diet-on-serum-omentin-and-adiponectin-levels-a-randomized-cross-over-clinical-trial-among-overweight-women
#2
Akram Kabiri, Mohammad Javad Hosseinzadeh-Attar, Fahimeh Haghighatdoost, Mohammadreza Eshraghian, Ahmad Esmaillzadeh
This study aimed to investigate the effect of olive oil-rich diet on omentin and adiponectin concentrations. This cross-over randomized trial included 17 overweight women. Participants were assigned to consume either a usual (16% saturated fatty acids [SFA] and 8% monounsaturated fatty acid [MUFA]) or an olive oil-rich diet (16% MUFA and 8% SFA) for 6 weeks crossing over after a 2-week washout period. There was no significant difference in the changes of omentin between two dietary interventions. However, in the adjusted model for polyunsaturated fatty acids and fat mass, usual diet tended to decrease omentin levels whilst olive oil-rich diet tended to increase (-56...
December 8, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27927977/ppar-mrna-levels-are-modified-by-dietary-n-3-fatty-acid-restriction-and-energy-restriction-in-the-brain-and-liver-of-growing-rats
#3
Matthew J Picklo, LuAnn Johnson, Joseph Idso
BACKGROUND: Without dietary sources of n-3 (ω-3) long-chain polyunsaturated fatty acids (LCPUFAs), α-linolenic acid (ALA; 18:3n-3) is the precursor for docosahexaenoic acid (DHA; 22:6n-3). It is not known how energy restriction (ER) affects ALA conversion to DHA. OBJECTIVE: We tested the hypothesis that ER reduces n-3 LCPUFA concentrations in tissues of growing rats fed diets replete with and deficient in ALA. METHODS: Male Sprague-Dawley rats (23 d old) were provided AIN93G diets (4 wk) made with soybean oil (SO; ALA sufficient) or corn oil (CO; ALA deficient) providing 16% of energy as fat...
December 7, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27923448/fit-with-good-fat-the-role-of-n-3-polyunsaturated-fatty-acids-on-exercise-performance
#4
REVIEW
Mariasole Da Boit, Angus M Hunter, Stuart R Gray
N-3 PUFA (n-3) polyunsaturated fatty acids (PUFA) are a family of fatty acids mainly found in oily fish and fish oil supplements. The effects of n-3 PUFA on health are mainly derived from its anti-inflammatory proprieties and its influence on immune function. Lately an increased interest in n-3 PUFA supplementation has reached the world of sport nutrition, where the majority of athletes rely on nutrition strategies to improve their training and performance. A vast amount of attention is paid in increasing metabolic capacity, delaying the onset of fatigue, and improving muscle hypertrophy and neuromuscular function...
January 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27923447/amelioration-of-non-alcoholic-fatty-liver-disease-with-npc1l1-targeted-igy-or-n-3-polyunsaturated-fatty-acids-in-mice
#5
Jin-Sik Bae, Jong-Min Park, Junghoon Lee, Byung-Chul Oh, Sang-Ho Jang, Yun Bin Lee, Young-Min Han, Chan-Young Ock, Ji-Young Cha, Ki-Baik Hahm
Patients with non-alcoholic fatty liver disease (NAFLD) have an increased risk for progression to hepatocellular carcinoma in addition to comorbidities such as cardiovascular and serious metabolic diseases; however, the current therapeutic options are limited. Based on our previous report that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can significantly ameliorate high fat diet (HFD)-induced NAFLD, we explored the therapeutic efficacy of n-3 PUFAs and N-IgY, which is a chicken egg yolk-derived IgY specific for the Niemann-Pick C1-Like 1 (NPC1L1) cholesterol transporter, on NAFLD in mice...
January 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27920979/transcript-profiling-in-the-milk-of-dairy-ewes-fed-extruded-linseed
#6
Tommaso Giordani, Alberto Vangelisti, Giuseppe Conte, Andrea Serra, Lucia Natali, Annamaria Ranieri, Marcello Mele, Andrea Cavallini
The identification of genes regulating milk secretion by mammary glands is a key-step for exploiting changes in milk composition induced by different diet regimens. Linseed supplementation is a reliable feeding strategy to enhance polyunsaturated fatty acid content in milk fat from sheep, increasing milk quality and nutraceutical value. To investigate the molecular bases of diet induced differences in milk composition, we collected milk from dairy ewes at 90 day of lactation and after 3 weeks of diet supplementation with extruded linseed...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/27917847/poultry-products-enriched-with-nutricines-have-beneficial-effects-on-human-health
#7
Gordana Kralik, Zlata Kralik
The paper presents nutritive value of broiler meat and table eggs, as these animal products are used for human nutrition on a daily basis. In the Republic of Croatia, average consumption of poultry meat amounts to 18.3 kg and to 160 eggs per capita.The most quality parts of broiler carcass are breasts and drumsticks with thighs. Breast muscles contain 21-23% protein, 1.90-1.97% fat, 75.28-76.01% water and 0.74-0.77% collagen. Thigh muscles contain 4.70-6.05% fat, 19.03-19.93% protein and 0.91-1.13% collagen...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/27910718/substituting-poly-and-mono-unsaturated-fat-for-dietary-carbohydrate-reduces-hyperinsulinemia-in-women-with-polycystic-ovary-syndrome
#8
Dalia Perelman, Nicole Coghlan, Cindy Lamendola, Susan Carter, Fahim Abbasi, Tracey McLaughlin
OBJECTIVE: Hyperinsulinemia is a prevalent feature of polycystic ovary syndrome (PCOS), contributing to metabolic and reproductive manifestations of the syndrome. Weight loss reduces hyperinsulinemia but weight regain is the norm, thus preventing long-term benefits. In the absence of weight loss, replacement of dietary carbohydrate (CHO) with mono/polyunsaturated fat reduces ambient insulin concentrations in non-PCOS subjects. The current study evaluated whether this dietary intervention could ameliorate hyperinsulinemia in women with PCOS...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27909891/canola-oil-rich-in-oleic-acid-improves-diastolic-heart-function-in-diet-induced-obese-rats
#9
Sijo Joseph Thandapilly, Pema Raj, Xavier Lieben Louis, Danielle Perera, Prasanga Yamanagedara, Peter Zahradka, Carla G Taylor, Thomas Netticadan
Obesity is a leading cause of cardiovascular disease. It directly affects heart structure and function and contributes to heart failure. Diet is a major factor involved in the development of obesity along with genetic factors. We examined the effects of monounsaturated and polyunsaturated fatty acid-rich oils on cardiac structure and function in the diet-induced rodent model of obesity (DIO). Obese prone (OP) rats were fed a high-fat diet (HF; 55% of kcal) for 12 weeks; Sprague-Dawley rats fed commercial chow served as control...
December 1, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27906983/tithonia-diversifolia-as-a-supplementary-feed-for-dairy-cows
#10
Rafael Sandin Ribeiro, Stephanie Amelia Terry, João Paulo Sacramento, Sylvia Rocha E Silveira, Cláudia Braga Pereira Bento, Elsa Fernandes da Silva, Hilário Cuquetto Mantovani, Marco Antônio Sundfeld da Gama, Luiz Gustavo Ribeiro Pereira, Thierry Ribeiro Tomich, Rogério Martins Maurício, Alexandre Vieira Chaves
The objective of this study was to examine the effects of Tithonia diversifolia as a supplementary forage on dairy cow performance and methane production. Nine lactating Holstein × Zebu dairy cows (519 ± 53.3 kg of body weight and 66 ± 13.3 d in milk) were paired by milk yield (21.3 ± 2.34 kg/d) and body weight and randomly assigned to three dietary treatments in a Latin square design with 21-d experimental periods (14 d for diet adaptation and 7 d for measurements and sample collection). The dietary treatments included the control diet consisting of fresh sugar cane plus concentrate (44:56, % of diet DM), and two treatment diets containing different levels of fresh T...
2016: PloS One
https://www.readbyqxmd.com/read/27905210/erythrocyte-fatty-acid-composition-does-not-influence-levels-of-free-bioavailable-and-total-25-hydroxy-vitamin-d
#11
Martin Carlsson, Ingela Nilsson, Lars Brudin, Siv-Ping Von, Pär Wanby
In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. FAs incorporated as phospholipids in erythrocyte (ery-) cell membranes reflect dietary intake. The purpose of this study was to investigate ery-FA composition in relation to markers for vitamin D. In healthy females (age 22.6 ± 2.0 years) total 25(OH)D was measured by LC-MS/MS (n = 78), free 25(OH)D with ELISA (n = 64 of 78), and bioavailable 25(OH)D was calculated...
December 1, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27903520/visceral-adiposity-and-metabolic-syndrome-after-very-high-fat-and-low-fat-isocaloric-diets-a-randomized-controlled-trial
#12
Vivian L Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H Larsen, Jan Erik Nordrehaug, Ottar K Nygård, Jørn V Sagen, Oddrun A Gudbrandsen, Simon N Dankel, Gunnar Mellgren
BACKGROUND: Different aspects of dietary pattern, including macronutrient and food profiles, may affect visceral fat mass and metabolic syndrome. OBJECTIVE: We hypothesized that consuming energy primarily from carbohydrate or fat in diets with similar food profiles would differentially affect the ability to reverse visceral adiposity and metabolic syndrome. DESIGN: Forty-six men (aged 30-50 y) with body mass index (in kg/m(2)) >29 and waist circumference >98 cm were randomly assigned to a very high-fat, low-carbohydrate (VHFLC; 73% of energy fat and 10% of energy carbohydrate) or low-fat, high-carbohydrate (LFHC; 30% of energy fat and 53% of energy carbohydrate) diet for 12 wk...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27895108/the-effect-of-dietary-fish-oil-on-weight-gain-and-insulin-sensitivity-is-dependent-on-apoe-genotype-in-humanized-targeted-replacement-mice
#13
Kenna E Slim, David Vauzour, Noemi Tejera, Peter J Voshol, Aedin Cassidy, Anne Marie Minihane
We investigated the independent and interactive impact of the common APOE genotype and marine n-3 polyunsaturated fatty acids (PUFA) on the development of obesity and associated cardiometabolic dysfunction in a murine model. Human APOE3 and APOE4 targeted replacement mice were fed either a high-fat control diet (HFD) or a HFD supplemented with 3% n-3 PUFA from fish oil (HFD + FO) for 8 wk. We established the impact of intervention on food intake, bodyweight, and visceral adipose tissue (VAT) mass; plasma, lipids (cholesterol and triglycerides), liver enzymes, and adipokines; glucose and insulin during an intraperitoneal glucose tolerance test; and Glut4 and ApoE expression in VAT...
November 28, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27891824/lipidomic-profiling-of-high-fat-diet-induced-obesity-in-mice-importance-of-cytochrome-p450-derived-fatty-acid-epoxides
#14
Weicang Wang, Jun Yang, Weipeng Qi, Haixia Yang, Chang Wang, Bowen Tan, Bruce D Hammock, Yeonhwa Park, Daeyoung Kim, Guodong Zhang
OBJECTIVE: Enzymatic metabolism of polyunsaturated fatty acids leads to formation of bioactive lipid metabolites (LMs). Previous studies have shown that obesity leads to deregulation of LMs in adipose tissues. However, most previous studies have focused on a single or limited number of LMs, and few systematical analyses have been carried out. METHODS: A LC-MS/MS-based lipidomics approach was used, which can analyze >100 LMs produced by cyclooxygenase, lipoxygenase, and cytochrome P450 (CYP) enzymes, to analyze the profile of LMs in high-fat diet-induced obesity in mice...
November 28, 2016: Obesity
https://www.readbyqxmd.com/read/27891208/endogenous-n-3-fatty-acids-alleviate-carbon-tetrachloride-induced-acute-liver-injury-in-fat-1-transgenic-mice
#15
Ruibing Feng, Meng Wang, Chunyan Yan, Peng Li, Meiwan Chen, Chengwei He, Jian-Bo Wan
n-3 polyunsaturated fatty acids (PUFAs) are beneficial for numerous models of liver diseases. The probable protective effects of n-3 PUFA against carbon-tetrachloride- (CCl4-) induced acute liver injury were evaluated in a fat-1 transgenic mouse that synthesizes endogenous n-3 from n-6 PUFA. Fat-1 mice and their WT littermates were fed a modified AIN93 diet containing 10% corn oil and were injected intraperitoneally with a single dose of CCl4 or vehicle. CCl4 challenge caused severe liver injury in WT mice, as indicated by serum parameters and histopathological changes, which were remarkably ameliorated in fat-1 mice...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27887752/changes-in-plasma-fatty-acid-composition-are-associated-with-improvements-in-obesity-and-related-metabolic-disorders-a-therapeutic-approach-to-overweight-adolescents
#16
Marcela Guerendiain, Rosa Montes, Gemma López-Belmonte, Miguel Martín-Matillas, Ana I Castellote, Elena Martín-Bautista, Amelia Martí, J Alfredo Martínez, Luis Moreno, Jesús Mª Garagorri, Julia Wärnberg, Javier Caballero, Ascensión Marcos, M Carmen López-Sabater, Cristina Campoy
BACKGROUND & AIMS: In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents...
November 11, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27886622/linoleic-acid-causes-greater-weight-gain-than-saturated-fat-without-hypothalamic-inflammation-in-the-male-mouse
#17
Kyle J Mamounis, Ali Yasrebi, Troy A Roepke
A significant change in the Western diet, concurrent with the obesity epidemic, was a substitution of saturated fatty acids with polyunsaturated, specifically linoleic acid (LA). Despite increasing investigation on type as well as amount of fat, it is unclear which fatty acids are most obesogenic. The objective of this study was to determine the obesogenic potency of LA vs. saturated fatty acids and the involvement of hypothalamic inflammation. Forty-eight mice were divided into four groups: low-fat or three high-fat diets (HFDs, 45% kcals from fat) with LA comprising 1%, 15% and 22...
November 4, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27884102/gene-expression-profile-of-intramuscular-muscle-in-nellore-cattle-with-extreme-values-of-fatty-acid
#18
Mariana P Berton, Larissa F S Fonseca, Daniela F J Gimenez, Bruno L Utembergue, Aline S M Cesar, Luiz L Coutinho, Marcos Vinicius A de Lemos, Carolyn Aboujaoude, Angélica S C Pereira, Rafael M de O Silva, Nedenia B Stafuzza, Fabieli L B Feitosa, Hermenegildo L J Chiaia, Bianca F Olivieri, Elisa Peripolli, Rafael L Tonussi, Daniel M Gordo, Rafael Espigolan, Adrielle M Ferrinho, Lenise F Mueller, Lucia G de Albuquerque, Henrique N de Oliveira, Susan Duckett, Fernando Baldi
BACKGROUND: Fatty acid type in beef can be detrimental to human health and has received considerable attention in recent years. The aim of this study was to identify differentially expressed genes in longissimus thoracis muscle of 48 Nellore young bulls with extreme phenotypes for fatty acid composition of intramuscular fat by RNA-seq technique. RESULTS: Differential expression analyses between animals with extreme phenotype for fatty acid composition showed a total of 13 differentially expressed genes for myristic (C14:0), 35 for palmitic (C16:0), 187 for stearic (C18:0), 371 for oleic (C18:1, cis-9), 24 for conjugated linoleic (C18:2 cis-9, trans11, CLA), 89 for linoleic (C18:2 cis-9,12 n6), and 110 genes for α-linolenic (C18:3 n3) fatty acids...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27883264/mucosa-associated-biohydrogenating-microbes-protect-the-simulated-colon-microbiome-from-stress-associated-with-high-concentrations-of-poly-unsaturated-fat
#19
Rosemarie De Weirdt, Emma Hernandez-Sanabria, Veerle Fievez, Eva Mees, Annelies Geirnaert, Florence Van Herreweghen, Ramiro Vilchez-Vargas, Pieter Van den Abbeele, Ruy Jauregui, Dietmar H Pieper, Bruno Vlaeminck, Tom Van de Wiele
Polyunsaturated fatty acids (PUFAs) may affect colon microbiome homeostasis by exerting (specific) antimicrobial effects and/or interfering with mucosal biofilm formation at the gut mucosal interface. We used standardized batch incubations and the Mucosal-Simulator of the Human Microbial Intestinal Ecosystem (M-SHIME) to show the in vitro luminal and mucosal effects of the main PUFA in the Western diet, linoleic acid (LA). High concentrations of LA were found to decrease butyrate production and Faecalibacterium prausnitzii numbers dependent on LA biohydrogenation to vaccenic acid (VA) and stearic acid (SA)...
November 24, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27881409/intake-of-individual-saturated-fatty-acids-and-risk-of-coronary-heart-disease-in-us-men-and-women-two-prospective-longitudinal-cohort-studies
#20
Geng Zong, Yanping Li, Anne J Wanders, Marjan Alssema, Peter L Zock, Walter C Willett, Frank B Hu, Qi Sun
OBJECTIVES:  To investigate the association between long term intake of individual saturated fatty acids (SFAs) and the risk of coronary heart disease, in two large cohort studies. DESIGN:  Prospective, longitudinal cohort study. SETTING:  Health professionals in the United States. PARTICIPANTS:  73 147 women in the Nurses' Health Study (1984-2012) and 42 635 men in the Health Professionals Follow-up Study (1986-2010), who were free of major chronic diseases at baseline...
November 23, 2016: BMJ: British Medical Journal
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