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https://www.readbyqxmd.com/read/29412787/measurement-of-respiratory-function-decline-in-patients-with-duchenne-muscular-dystrophy-a-conjoint-analysis
#1
Elena Ripamonti, Grazia D'Angelo
AIM: In Duchenne muscular dystrophy (DMD), little attention has been paid to severity of respiratory function decline (RFD) based on disease progression. We performed a conjoint analysis among 123 Italian clinicians to generate a scale for RFD in DMD patients. METHODS: Before the interview, 11 attributes were selected by discussion among experts. Thirty-two 'patient profiles' were generated. Each physician assessed the severity of RFD for each profile. Each level/attribute was assigned an estimated usefulness to understand its impact on RFD...
February 7, 2018: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29404723/physiological-predictors-of-respiratory-and-cough-assistance-needs-after-extubation
#2
Nicolas Terzi, Frédéric Lofaso, Romain Masson, Pascal Beuret, Hervé Normand, Edith Dumanowski, Line Falaize, Bertrand Sauneuf, Cédric Daubin, Jennifer Brunet, Djillali Annane, Jean-Jacques Parienti, David Orlikowski
BACKGROUND: Identifying patients at high risk of post-extubation acute respiratory failure requiring respiratory or mechanical cough assistance remains challenging. Here, our primary aim was to evaluate the accuracy of easily collected parameters obtained before or just after extubation in predicting the risk of post-extubation acute respiratory failure requiring, at best, noninvasive mechanical ventilation (NIV) and/or mechanical cough assistance and, at worst, reintubation after extubation...
February 5, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29398295/genotype-and-other-determinants-of-respiratory-function-in-myotonic-dystrophy-type-1
#3
Ghilas Boussaïd, Karim Wahbi, Pascal Laforet, Bruno Eymard, Tanya Stojkovic, Anthony Behin, Annane Djillali, David Orlikowski, Hélène Prigent, Frédéric Lofaso
New treatments are being developed for myotonic dystrophy type 1 (DM1). To evaluate their efficacy, knowledge about the natural history of respiratory dysfunction and its relationship with the genotype will be crucial. Also needed is information on factors predicting the time-course of respiratory function in DM1. Using data from 283 patients, we built a segmented linear mixed-effects regression model to assess respiratory function changes over time. Respiratory variables associated with the CTG repeat number were identified by multivariate linear regression analysis...
December 26, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29309210/association-between-daily-ambient-air-pollution-and-respiratory-symptoms-in-children-with-asthma-and-healthy-children-in-western-japan
#4
Hideki Hasunuma, Shin Yamazaki, Kenji Tamura, Yoon Ha Hwang, Rintaro Ono, Yuko Amimoto, David J Askew, Hiroshi Odajima
OBJECTIVE: In recent years, air pollutant concentrations in Japan have decreased slightly; however, there are growing concerns about the influences of transnational air pollution on respiratory illness. We aimed to clarify the short-term association between the ambient air pollution and respiratory symptoms among children without asthma, children with asthma not using long-term medications (CA-nonLTM), and those using them (CA-LTM). METHODS: A total of 138 children attending 2 primary schools and 71 children with asthma regularly visiting cooperating medical institutions were recruited...
January 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29246611/effect-of-lee-silverman-voice-treatment-lsvt-loud%C3%A2-on-swallowing-and-cough-in-parkinson-s-disease-a-pilot-study
#5
Anna Miles, Marie Jardine, Felicity Johnston, Martin de Lisle, Philippa Friary, Jacqui Allen
PURPOSE: Lee Silverman Voice Treatment (LSVT LOUD®) is an effective therapy for phonation in Parkinson's Disease (PD) but little is known about any additional spread of effects to swallowing and cough function. This pilot study examined the effect of LSVT LOUD on pharyngeal swallowing parameters and reflexive cough strength. METHODS: Twenty participants (14 men, 6 women; mean 68years, SD3.5) with PD referred for LSVT LOUD with complaints of voice deterioration were recruited...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29231431/-micro-invasive-embedding-combined-with-montelukast-sodium-for-children-cough-variant-asthma-a-randomized-controlled-trial
#6
Xiaoyan Wang, Baoqin Liu, Bin Lu, Yanmei Zhang, Liran Wang, Haijin Li, Xue Han, Dan Ding
OBJECTIVE: To observe the effects of micro-invasive embedding combined with montelukast sodium and simple montelukast sodium for children cough variant asthma (CVA). METHODS: A total of 240 patients were randomly assigned into an observation group and a control group, 120 cases in each one. Considering of cases dropping, 101 patients in the observation group and 105 cases in the control group were included. Montelukast sodium chewable tablets were applied before sleep for 3 months in the control group, 5 mg a time, once a day...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29229113/measuring-voluntary-and-reflexive-cough-strength-in-healthy-individuals
#7
Claire Mills, Richard Jones, Maggie-Lee Huckabee
BACKGROUND: Cough reflex testing is a validated tool for identifying patients at risk of silent aspiration. However, inter- and intra-rater reliabilities of perceptual judgements of cough strength are sub-optimal. Although there are clinically established methods for measuring volitional cough strength, no similar methods are identified for reflexive cough strength. This study evaluated three measurement methods of voluntary and suppressed reflexive cough strength. METHODS: Fifty-three healthy subjects (≥50 years) participated in this study...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29202684/voluntary-cough-intensity-and-its-influencing-factors-differ-by-sex-in-community-dwelling-adults
#8
Akiko Yawata, Atsuhiro Tsubaki, Haruka Yawata, Haruna Takai, Kayomi Matsumoto, Nana Takehara, Ryosaku Kobayashi
BACKGROUND: Cough peak flow (CPF) is widely used for measuring voluntary cough intensity. However, the respective factors that affect CPF are not known. The aim of this study was to determine the factors affecting CPF by sex in community-dwelling adults. METHOD: We recruited participants using posters exhibited at a public gymnasium. Participation was voluntary, and all participants provided informed consent. Nonsmoking community residents (102 males, 49.6 ± 20...
December 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29200637/combined-respiratory-muscle-training-facilitates-expiratory-muscle-activity-in-stroke-patients
#9
Myeong-Rae Jo, Nan-Soo Kim
[Purpose] The aim of this study was to investigate the effect of combined respiratory muscle training on expiratory muscle activity in stroke patients. [Subjects and Methods] Twenty-five stroke patients were assigned to either the intervention group (n=12) or the control group (n=13). Both groups participated in a conventional stroke rehabilitation program, while the intervention group also received respiratory muscle training for 20 to 30 minutes a day, 3 times a week, for 8 weeks. Surface electromyographic data were collected from the rectus abdominis, internal oblique, and external oblique on the paretic side...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29162060/long-term-prognosis-of-chronic-cough-a-prospective-observational-cohort-study
#10
Heikki O Koskela, Anne M Lätti, Minna K Purokivi
BACKGROUND: The long-term prognosis of chronic cough and its determinants need to be clarified. METHODS: This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks' duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Questionnaire (LCQ), skin prick tests, ambulatory peak expiratory flow monitoring, spirometry before and after 0.4 mgs of salbutamol, exhaled nitric oxide concentration measurement, hypertonic saline cough provocation test, and histamine bronchial provocation test...
November 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29114887/cough-strength-and-expiratory-force-in-aspirating-and-nonaspirating-postradiation-head-and-neck-cancer-survivors
#11
Katherine A Hutcheson, Martha P Barrow, Carla L Warneke, Yiqun Wang, George Eapen, Stephen Y Lai, Denise A Barringer, Emily K Plowman, Jan S Lewin
OBJECTIVE: Expiratory functions that clear aspiration from the airway are compromised in patients with neurogenic dysphagia for whom cough and expiratory force may be impaired by the primary disease process. The relationship between expiratory function, cough, and aspiration is less clear in head and neck cancer (HNC) survivors for whom the disease process does not directly impact the lower respiratory system. Our objective was to compare mechanisms of airway clearance (expiratory force and cough) with aspiration status in postradiated HNC survivors...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29104754/poor-cough-flow-in-acute-stroke-patients-is-associated-with-reduced-functional-residual-capacity-and-low-cough-inspired-volume
#12
Katie Ward, Prashant Rao, Charles C Reilly, Gerrard Francis Rafferty, Michael I Polkey, Lalit Kalra, John Moxham
Introduction: Each year 7 million people die of stroke worldwide; most deaths are caused by chest infections. Patients with acute stroke have impaired voluntary cough flow, associated with increased risk of chest infections. Reduced functional residual capacity (FRC) could lead to impaired cough flow. We therefore compared FRC in acute hemiparetic stroke patients and controls and explored its relationship with volume inspired before cough and voluntary cough peak flow. Methods: 21 patients within 2 weeks of first-ever middle cerebral artery territory (MCA) infarct (mean (SD) age 68 (11) years, 10 females) and 30 controls (58 (11) years, 15 females) underwent FRC and voluntary cough testing (cough inspired volume and peak flow) while semirecumbent...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29060142/classification-of-voluntary-coughs-applied-to-the-screening-of-respiratory-disease
#13
Christian Infante, Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher
Pulmonary and respiratory diseases (e.g. asthma, COPD, allergies, pneumonia, tuberculosis, etc.) represent a large proportion of the global disease burden, mortality, and disability. In this context of creating automated diagnostic tools, we explore how the analysis of voluntary cough sounds may be used to screen for pulmonary disease. As a clinical study, voluntary coughs were recorded using a custom mobile phone stethoscope from 54 patients, of which 7 had COPD, 15 had asthma, 11 had allergic rhinitis, 17 had both asthma and allergic rhinitis, and four had both COPD and allergic rhinitis...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29034296/diagnosis-of-asthma-in-symptomatic-children-based-on-measures-of-lung-function-an-analysis-of-data-from-a-population-based-birth-cohort-study
#14
Clare Murray, Philip Foden, Lesley Lowe, Hannah Durrington, Adnan Custovic, Angela Simpson
BACKGROUND: Concerns have been expressed about asthma overdiagnosis. The UK National Institute of Health and Care Excellence (NICE) proposed a new diagnostic algorithm applying four lung function measures sequentially (ratio of forced expiratory volume in 1 s [FEV1] to forced vital capacity [FVC] <70%, bronchodilator reversibility ≥12%, fractional exhaled nitric oxide [FeNO] ≥35 parts per billion, and peak expiratory flow variability >20%). We aimed to assess the diagnostic value of three of the tests individually, and then test the proposed algorithm in symptomatic children...
October 2017: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/28935013/-can-preoperative-peak-expiratory-flow-predict-postoperative-pulmonary-complications-in-lung-cancer-patients-undergoing-lobectomy
#15
Kun Zhou, Yanming Wu, Jianhua Su, Yutian Lai, Cheng Shen, Pengfei Li, Guowei Che
BACKGROUND: Postoperative pulmonary complications (PPCs), especially postoperative pneumonia (POP), directly affect the rapid recovery of lung cancer patients after surgery. Peak expiratory flow (PEF) can reflect airway patency and cough efficiency. Moreover, cough impairment may lead to accumulation of pulmonary secretions which can increase the risk of PPCs. The aim of this study is to investigate the effect of preoperative PEF on PPCs in patients with lung cancer. METHODS: Retrospective research was conducted on 433 lung cancer patients who underwent lobectomy at the West China Hospital of Sichuan University from January 2014 to December 2015...
September 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28900041/predicting-extubation-outcome-by-cough-peak-flow-measured-using-a-built-in-ventilator-flow-meter
#16
Florent Gobert, Hodane Yonis, Romain Tapponnier, Raul Fernandez, Marie-Aude Labaune, Jean-François Burle, Jack Barbier, Bernard Vincent, Maria Cleyet, Jean-Christophe Richard, Claude Guérin
BACKGROUND: Successful weaning from mechanical ventilation depends on the patient's ability to cough efficiently. Cough peak flow (CPF) could predict extubation success using a dedicated flow meter but required patient disconnection. We aimed to predict extubation outcome using an overall model, including cough performance assessed by a ventilator flow meter. METHODS: This was a prospective observational study conducted from November 2014 to October 2015. Before and after a spontaneous breathing trial, subjects were encouraged to cough as strongly as possible before freezing the ventilator screen to assess CPF and tidal volume (VT) in the preceding inspiration...
September 12, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28900040/reduced-diaphragm-excursion-during-reflexive-citric-acid-cough-test-in-subjects-with-subacute-stroke
#17
Yong-Min Choi, Geun-Young Park, Yeonji Yoo, Donggyun Sohn, YongJun Jang, Sun Im
BACKGROUND: Diaphragm excursion is limited during respiratory maneuvers after a stroke. How the diaphragm is limited during reflexive coughs and affects the effectiveness of cough in stroke patients is unclear. This study aimed to measure reflexive cough strength by cough peak flow (CPF) induced by citric acid nebulization (2.8 mol/L), record diaphragm excursions during reflexive coughs in stroke subjects at risk of silent aspiration, and compare these values with those of stroke subjects without risk of aspiration or dysphagia...
September 12, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28894819/computational-modelling-of-cough-function-and-airway-penetrant-behavior-in-patients-with-disorders-of-laryngeal-function
#18
Bari Hoffman Ruddy, Don Nadun Kuruppumullage, Giselle Carnaby, Michael Crary, Jeffery Lehman, Olusegun J Ilegbusi
OBJECTIVE/HYPOTHESIS: Patients with laryngeal disorders often exhibit changes to cough function contributing to aspiration episodes. Two primary cough variables (peak cough flow: PCF and compression phase duration: CPD) were examined within a biomechanical model to determine their impact on characteristics that impact airway compromise. STUDY DESIGN: Computational study. METHODS: A Computational Fluid Dynamics (CFD) technique was used to simulate fluid flow within an upper airway model reconstructed from patient CT images...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28829884/effect-of-oral-prednisolone-on-symptom-duration-and-severity-in-nonasthmatic-adults-with-acute-lower-respiratory-tract-infection-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Alastair D Hay, Paul Little, Anthony Harnden, Matthew Thompson, Kay Wang, Denise Kendrick, Elizabeth Orton, Sara T Brookes, Grace J Young, Margaret May, Sandra Hollinghurst, Fran E Carroll, Harriet Downing, David Timmins, Natasher Lafond, Magdy El-Gohary, Michael Moore
Importance: Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. Objective: To assess the effects of oral corticosteroids for acute lower respiratory tract infection in adults without asthma. Design, Setting, and Participants: Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014) conducted in 54 family practices in England among 401 adults with acute cough and at least 1 lower respiratory tract symptom not requiring immediate antibiotic treatment and with no history of chronic pulmonary disease or use of asthma medication in the past 5 years...
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28743265/the-predictive-value-of-respiratory-function-tests-for-non-invasive-ventilation-in-amyotrophic-lateral-sclerosis
#20
T B M Tilanus, J T Groothuis, J M C TenBroek-Pastoor, T B Feuth, Y F Heijdra, J P L Slenders, J Doorduin, B G Van Engelen, M J Kampelmacher, J Raaphorst
BACKGROUND: Non-invasive ventilation (NIV) improves survival and quality of life in amyotrophic lateral sclerosis (ALS) patients. The timing of referral to a home ventilation service (HVS), which is in part based on respiratory function tests, has shown room for improvement. It is currently unknown which respiratory function test predicts an appropriate timing of the initiation of NIV. METHODS: We analysed, retrospectively, serial data of five respiratory function tests: forced vital capacity (FVC), peak cough flow (PCF), maximum inspiratory and expiratory pressure (MIP and MEP) and sniff nasal inspiratory pressure (SNIP) in patients with ALS...
July 25, 2017: Respiratory Research
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