keyword
https://read.qxmd.com/read/38486426/synthesis-spectroscopic-analysis-and-computational-based-investigations-on-azo-coumarin-co-ii-galangin-hybrids-exhibit-multipotential-activities
#21
JOURNAL ARTICLE
Shasank Sekhar Swain, Alaka Sahoo, Satya Ranjan Singh, Jyotirmaya Sahoo, Sudhir Kumar Paidesetty
The present study synthesized a series of cobalt (II) metal ion frame hybrid candidates ( 6a-6f ) bearing phyto-flavonol galangin with substituted aryl diazenyl coumarins, and further structural confirmation was validated by various spectral techniques, including NMR, ATR-FTIR, UV-vis, HPLC, XRD, etc. Therapeutic potency was investigated via PASS (prediction of activity spectra for substances), molecular docking, molecular dynamics simulation, prediction of toxicity, pharmacokinetics, and drug-likeness scores, along with the highest occupied molecular orbital (HOMO), the lowest unoccupied molecular orbital (LUMO), with their energy gaps (ΔEH-L ) to locate the most potential therapeutic candidates...
March 14, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38486382/molecular-docking-and-admet-analysis-strategy-based-stability-indicating-rp-hplc-pda-method-development-and-validation-of-toremifene
#22
JOURNAL ARTICLE
Shamshir Khan, Makhmur Ahmad, Zabih Ullah, Sana Hashmi, Md Sajid Ali, Sharwan Hudda
BACKGROUND: The purpose of this research is to develop an analytical method and validate it according to ICH guidelines for the estimation of Toremifene by RP-HPLC-PDA with molecular docking and ADMET analysis. From molecular docking, it came to know the receptor affinity specifically to estrogen receptors (ERα and ERβ), which are responsible for cancer therapy. ADMET analyses secure its therapeutic potential as well safety of the drug. METHODS: An isocratic method has developed by RP-HPLC-PDA (AGILENT 1100) with symmetry of 100 mm x 4...
March 13, 2024: Current Computer-aided Drug Design
https://read.qxmd.com/read/38486151/cyanobacterial-elicitor-enhances-the-biomass-of-mentha-piperita-l-and-improves-the-production-of-high-value-rosmarinic-acid-under-in-vitro-culture-of-apical-meristem
#23
JOURNAL ARTICLE
Zeinab Shariatmadari, Somayeh Zarezadeh, Hossein Riahi, Ali Akbar Ghotbi-Ravandi, Mehri Seyed Hashtroudi, Ensiyeh Shahroudi
BACKGROUND: Rosmarinic acid (RA), like other phenolic compounds, is sources of antioxidants and anti-inflammatory agents in medicinal plants. In vitro culture of plants can improve the medicinal plants' metabolite profile and phenolic compound quantity. To date, various methods have been proposed to increase this medicinal metabolite in plants, among which the use of bioelicitors can be mentioned. In the present study, a native isolate of heterocystous cyanobacteria, Nostoc spongiaeforme var...
March 15, 2024: BMC Plant Biology
https://read.qxmd.com/read/38485465/preparation-characterization-and-radiolabeling-of-anti-her2-scfv-with-technetium-tricarbonyl-and-stability-studies
#24
JOURNAL ARTICLE
Negar Bozorgchami, Maryam Ahmadzadeh, Dara Hatamabadi, Abdolreza Yazdani, Soraya Shahhosseini, Elham Mohit
Breast cancer is the most common diagnosed cancer, and the second cause of cancer death among women, worldwide. HER2 overexpression occurred in approximately 15% to 20% of breast cancers. Invasive biopsy method has been used for detection of HER2 overexpression. HER2-targeted imaging via an appropriate radionuclide is a promising method for sensitive and accurate identification of HER2+ primary and metastatic lesions. 99m Tc-anti-HER2 scFv can specifically target malignancies and be used for diagnosis of the cancer type and metastasis as well as treatment of breast cancer...
March 14, 2024: Journal of Labelled Compounds & Radiopharmaceuticals
https://read.qxmd.com/read/38485442/sources-and-profiles-of-toxins-in-shellfish-from-the-south-central-coast-of-chile-36%C3%A2-%C3%A2-43%C3%A2-s
#25
JOURNAL ARTICLE
Luis Norambuena-Subiabre, Pamela Carbonell, Pablo Salgado, Claudia Zamora, Oscar Espinoza-González
The study of marine toxins in shellfish is of the utmost importance to ensure people's food safety. Marine toxins in shellfish and microalgae in the water column off the south-central coast of Chile (36°‒43° S) were studied in a network of 64 stations over a 14-month period. The relative abundance of harmful species Alexandrium catenella, Alexandrium ostenfeldii, Protoceratium reticulatum, Dinophysis acuminata, Dinophysis acuta, Pseudo-nitzschia seriata group and P. delicatissima group was analyzed...
March 2024: Harmful Algae
https://read.qxmd.com/read/38485073/enhancing-the-efficient-degradation-of-bps-using-the-bpns-cds-composite-catalyst-under-visible-light
#26
JOURNAL ARTICLE
Xiaolong Rong, Ying Han, Hao Dai, Haixia Jiang, Yingang Xue
Black phosphorus nanosheets (BPNS), a novel two-dimensional nanomaterial, find extensive applications in the field of photocatalysis. With the prohibition of bisphenol A (BPA), the utilization of bisphenol S (BPS), which is more resistant to degradation than BPA, has been steadily increasing. In this study, few-layer BPNS was prepared using an improved liquid-phase exfoliation method, showcasing its commendable specific surface area and notable adsorption capacity. Subsequently, a new type of nanocomposite material, BPNS-Cadmium sulfide (CdS), was hydrothermal synthesized involving BPNS and CdS...
March 12, 2024: Environmental Research
https://read.qxmd.com/read/38484961/expeditive-carbofuran-pesticide-degradation-by-submerged-thermal-plasma-and-its-accelerated-mineralization-by-persulfate-addition
#27
JOURNAL ARTICLE
Nagaraj Thirumurugan, Nanditta Nandy, Pasupathi Amarnath, Subramaniam Yugeswaran, Kalidass Suresh, Nachimuthu Krishnan Sujeeth, Murugesan Gnanadesigan
Rapid degradation of carbofuran (CBF) pesticide is effectively achieved by submerged thermal plasma (STP) without and with the addition of persulfate (PS) at two different concentrations (10 and 20 ppm). Degradation efficiency was examined using high-performance liquid chromatography (HPLC), and mineralization percentage was determined by total organic carbon (TOC) analysis. Adding 10 ppm PS showed higher degradation and mineralization percentages of 99.5% and 65.2%, respectively, than mere plasma treatment and 20 ppm PS addition to CBF solution...
March 12, 2024: Environmental Pollution
https://read.qxmd.com/read/38484954/sedative-and-hypnotic-effects-of-the-saponins-from-a-traditional-edible-plant-liriope-spicata-lour-in-pcpa-induced-insomnia-mice
#28
JOURNAL ARTICLE
Yi-Meng Li, Chun-Yan Shen, Jian-Guo Jiang
ETHNOPHARMACOLOGICAL RELEVANCE: Liriope spicata Lour., a species listed in the catalogue of 'Medicinal and Edible Homologous Species', is traditionally used for the treatment of fatigue, restlessness, insomnia and constipation. AIM OF THE STUDY: This study is aimed to evaluate the sedative and hypnotic effect of the saponins from a natural plant L. spicata Lour. in vivo. MATERIALS AND METHODS: The total saponin (LSTS) and purified saponin (LSPS) were extracted from L...
March 12, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38484862/food-selection-and-effect-of-home-preparation-procedure-for-antibiotic-food-mixtures-on-homogeneity-stability-and-dissolution
#29
JOURNAL ARTICLE
Rong Huang, Dongkai Zhu, Jiang Wang, Yvonne Berko, Patricia A Yu, Corinne M Parker, Yon C Yu, Xin Feng, Xiaoming Xu, Muhammad Ashraf
Amoxicillin, doxycycline, and clindamycin are among the commonly used antibiotics to treat bacterial infections. However, dosage forms of antibiotics for pediatric patients may not be as readily available as the formulations for adult patients. As such, it is anticipated that during a public health emergency, special instruction may need to be provided on home preparation and administration procedures to dose pediatric patients using available stockpiles of oral tablet and capsule dosage forms. Mixing crushed tablets or capsule contents with soft- or liquid- foods is one of the most common home preparation procedures...
March 12, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38484675/sensitive-reliable-and-simultaneous-determination-of-fingolimod-and-citalopram-drug-molecules-used-in-multiple-sclerosis-treatment-based-on-magnetic-solid-phase-extraction-and-hplc-pda
#30
JOURNAL ARTICLE
Esra Durgun, Halil İbrahim Ulusoy, İbrahim Narin
An analytical methodology has been developed for trace amounts of Fingolimod (FIN) and Citalopram (CIT) drug molecules based on magnetic solid phase extraction (MSPE) and high performance liquid chromatographic determination with photodiode array detector (HPLC-DAD). Fingolimod is used in treatment of Multiple sclerosis (MS) disease and sometimes antidepressant drugs such as citalopram accompany to treatment. Both simultaneous analysis of these molecules and application of MSPE with a new adsorbent has been performed for first times...
March 11, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38484624/effect-of-pulsatilla-decoction-on-vulvovaginal-candidiasis-in-mice-evidences-for-its-mechanisms-of-action
#31
REVIEW
Kaifan Hu, Xiaojuan Jiang, Jiaping Zhang, Dan Xia, Daqiang Wu, Jing Shao, Tianming Wang, Changzhong Wang
BACKGROUND: Vulvovaginal candidiasis (VVC) is a common infection that affects the female reproductive tract. Pulsatilla decoction (PD), a traditional Chinese herbal medicine, is a classic and effective prescription for VVC. However, its mechanism of action remains unclear. PURPOSE: This study aimed to evaluate the efficacy and potential mechanism of action of the n-butanol extract of Pulsatilla decoction (BEPD) in VVC treatment. METHODS: High performance liquid chromatography (HPLC) was used to detect the main active ingredients in BEPD...
March 8, 2024: Phytomedicine
https://read.qxmd.com/read/38484500/on-site-extraction-using-a-3d-printed-device-coated-with-zn-co-zif-derived-carbon-followed-by-an-on-line-sia-hplc-fl-system-for-fluoroquinolones-determination-in-wastewater
#32
JOURNAL ARTICLE
D Barzallo, A Están, N Crespí, C Palomino, G Turnes, E Palacio, L Ferrer
A 3D printed device covered with Zn/Co-ZIF-derived carbon allows the on-site extraction of fluoroquinolones (FQs) from wastewater, avoiding the sample transportation to the laboratory, and the subsequent elution, separation and determination using an on-line flow system based on sequential injection analysis (SIA) coupled to HPLC-FL. Several parameters that affect the extraction efficiency and desorption were optimized including the sorption phase immobilization technique on the 3D device, extraction time, pH effect, sample volume as well as the type of eluent, eluent volume, and flow rate...
March 11, 2024: Talanta
https://read.qxmd.com/read/38484116/phenolic-characterization-of-a-purple-maize-zea-mays-cv-moragro-by-hplc-qtof-ms-and-study-of-its-bioaccessibility-using-a-simulated-in-vitro-digestion-caco-2-culture-model
#33
JOURNAL ARTICLE
Marianela Desireé Rodriguez, Luisina Monsierra, Pablo Sebastián Mansilla, Gabriela Teresa Pérez, Sonia de Pascual-Teresa
The present work aimed to characterize the phenolic and antioxidant content of the Argentinian purple maize "Moragro" cultivar. Additionally, the INFOGEST simulated in vitro digestion model was used to establish the effect of digestion on bioactive compounds. Finally, digestion samples were used to treat Caco-2 cells in the transwell model to better understand their bioavailability. Twenty-six phenolic compounds were found in purple maize cv. "Moragro", 15 nonanthocyanins and 11 anthocyanins. Several compounds were identified in maize for the first time, such as pyrogallol, citric acid, gallic acid, kaempferol 3-(6″-ferulylglucoside), and kaempferol 3-glucuronide...
March 14, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38483874/vitamin-d-deficiency-and-the-vitamin-d-receptor-vdr-gene-polymorphism-rs2228570-foki-are-associated-with-an-increased-susceptibility-to-hypertension-among-the-bangladeshi-population
#34
JOURNAL ARTICLE
Imrul Kayes Nabil, Zimam Mahmud, Sonia Tamanna, Md Mostafijur Rahman, Gowhar Rashid, Md Sarowar Hossain, Humaira Binte Asad, Mohammad Amjad Kamal, Md Zakir Hossain Howlader
Vitamin D receptor (VDR) gene is implicated in hypertension vulnerability due to its role in regulating the renin-angiotensin system (RAS) and blood pressure. In this case-control study, a carefully selected cohort of 111 hypertensive individuals and 100 healthy controls underwent serum analysis using HPLC to measure 25-hydroxy vitamin D levels. Polymorphic variations in the VDR gene were detected and characterized using the PCR-RFLP method. At first, lower 25-hydroxy vitamin D levels were observed in hypertensive individuals compared to controls (p<0...
2024: PloS One
https://read.qxmd.com/read/38483118/synthesis-of-a-hydrophobic-phenanthrene-containing-universal-support-for-solid-phase-oligonucleotide-synthesis
#35
JOURNAL ARTICLE
Yasufumi Fuchi, Kuria Shiota, Yoshiyuki Hari
Universal solid supports are widely used in solid-phase oligonucleotide (ON) synthesis based on phosphoramidite chemistry. Herein, we describe the synthesis of hydrophobic universal linkers, namely phenanthrene ring-fused 7-oxabicyclo[2.2.1]heptane-2,3-diol derivatives (PT linkers), their coupling to solid supports [e.g., controlled pore glass (CPG) and polystyrene (PS)], and the use of the resulting PT-linker-modified solid supports in ON synthesis. PT linkers were synthesized in four steps from commercial materials and subsequently attached to CPG and PS resins through succinyl and diethylene glycol-containing spacers, respectively...
March 2024: Current protocols
https://read.qxmd.com/read/38481545/antispasmodic-cardioprotective-and-blood-pressure-lowering-properties-of-gomphrena-perennis-l-and-its-mechanisms-of-action
#36
JOURNAL ARTICLE
Adriana Milena Bonilla Bonilla, Tatiana C Gavilánez Buñay, Matías Bayley, Germán A Colareda, Soledad I Matera, María Luján Flores, Osvaldo León Córdoba, Julián J Prieto, María Esperanza Ruiz, Alicia E Consolini, María Inés Ragone
BACKGROUND: Gomphrena perennis L. is a native plant of South America whose pharmacological properties have not been studied yet. AIM: To evaluate the cardiovascular and intestinal pharmacological effects of Gomphrena perennis L. leaves tincture (GphT) and the mechanisms involved. EXPERIMENTAL PROCEDURE: The chromatographic profile of GphT was done. Its ex vivo effects were evaluated by contractile concentration-response curves (CRCs) obtained from the agonist carbachol or calcium found in isolated rat small intestine, as well as in the relaxant CRCs...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38480610/in-vitro-selection-of-lactic-acid-bacteria-to-combat-salmonella-enterica-and-campylobacter-jejuni-in-broiler-chickens
#37
JOURNAL ARTICLE
Ramesha N Wishna-Kadawarage, Rita M Hickey, Maria Siwek
Campylobacter and Salmonella are the two most prominent foodborne zoonotic pathogens reported in the European Union. As poultry is one of the major sources of these pathogens, it is imperative to mitigate the colonization of these pathogens in poultry. Many strains of lactic acid bacteria (LAB) have demonstrated anti-Salmonella and anti-Campylobacter characteristics to varying degrees and spectrums which are attributed to the production of various metabolites. However, the production of these compounds and consequent antimicrobial properties are highly strain dependent...
March 14, 2024: World Journal of Microbiology & Biotechnology
https://read.qxmd.com/read/38480557/long-term-disruption-of-tissue-levels-of-glutamate-and-glutamatergic-neurotransmission-neuromodulators-taurine-and-kynurenic-acid-induced-by-amphetamine
#38
JOURNAL ARTICLE
Ewa Taracha, Magdalena Czarna, Danuta Turzyńska, Alicja Sobolewska, Piotr Maciejak
RATIONALE: Chronic amphetamine (AMPH) use leading to addiction results in adaptive changes within the central nervous system that persist well beyond the drug's elimination from the body and can precipitate relapse. Notably, alterations in glutamatergic neurotransmission play a crucial role in drug-associated behaviours. OBJECTIVES: This study aimed to identify changes induced by amphetamine in glutamate levels and the neuromodulators of glutamatergic neurotransmission (taurine and kynurenic acid) observable after 14 and 28 days of abstinence in key brain regions implicated in addiction: the cortex (Cx), nucleus accumbens (Acb), and dorsolateral striatum (CPu-L)...
March 14, 2024: Psychopharmacology
https://read.qxmd.com/read/38480510/novel-bioresorbable-drug-eluting-mesh-scaffold-for-therapy-of-muscle-injury
#39
JOURNAL ARTICLE
Ying-Chao Chou, Yung-Heng Hsu, Demei Lee, Jheng-Wei Yang, Yi-Hsun Yu, Err-Cheng Chan, Shih-Jung Liu
A novel bioresorbable drug-eluting polycaprolactone (PCL) mesh scaffold was developed, utilizing a solvent-cast additive manufacturing technique, to promote therapy of muscle injury. The degradation rate and mechanical properties strength of the PCL mesh were characterized after immersion in a buffer solution for different times. The in vitro release characteristics of vancomycin, ceftazidime, and lidocaine from the prepared mesh were evaluated using a high-performance liquid chromatography (HPLC) assay. In addition, the in vivo efficacy of PCL meshes for the repair of muscle injury was investigated on a rat model with histological examinations...
March 13, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38479616/six-unprecedented-2-2-phenethyl-chromone-dimers-from-agarwood-of-aquilaria-filaria
#40
JOURNAL ARTICLE
Yuan Wei, Wen-Hua Dong, Wei Li, Jun Zeng, Hui-Qin Chen, Sheng-Zhuo Huang, Li Yang, Wen-Li Mei, Ya-Li Wang, Zhi-Yong Guo, Hao-Fu Dai, Hao Wang
Six new dimeric 2-(2-phenylethyl)chromones (1-6) were successfully isolated from the ethanol extract of agarwood of Aquilaria filaria from Philippines under HPLC-MS guidance. Compounds 1-6 are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and flindersia 2-(2-phenylethyl)chromone via a single ether bond, and the linkage site (C5-O-C8'') of compound 2 is extremely rare. A variety of spectroscopic methods were used to ascertain their structures, including extensive 1D and 2D NMR spectroscopic analysis, HRESIMS, and comparison with literature...
March 11, 2024: Fitoterapia
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