keyword
https://read.qxmd.com/read/38497721/-in-vitro-dissolution-equivalence-of-jordanian-sildenafil-generics-via-validated-stability-indicating-hplc-method
#1
JOURNAL ARTICLE
Hamdi Nsairat, Ali Al-Samydai, Mohamed El-Tanani, Ashok K Shakya, Somaya Ahmad, Shorouq Alsotari, Walhan Alshaer, Ammar Shanneir, Munib M Saket, Tawfiq A Arafat
This study was conducted to compare dissolution profiles of four Jordanian registered sildenafil (SDF) products to the originator. Dissolution samples were analyzed utilizing a validated and stability-indicating HPLC method in human plasma. Validation was performed for specificity, linearity, limit of detection, lower limit of quantification, precision, trueness and stability. SDF was extracted from plasma samples using liquid-liquid extraction. The analysis was performed utilizing isocratic elution on C18 column with 1...
March 18, 2024: Bioanalysis
https://read.qxmd.com/read/38496983/green-organo-photooxidative-method-for-the-degradation-of-methylene-blue-dye
#2
JOURNAL ARTICLE
Adnan Majeed, Ahmad H Ibrahim, Sawsan S Al-Rawi, Muhammad Adnan Iqbal, Muhammad Kashif, Muhammad Yousif, Zain Ul Abidin, Shahzaib Ali, Muhammad Arbaz, Syed Arslan Hussain
This study used an organophoto-oxidative material to degrade the toxic azo dye, methylene blue (MB), due to its hazardous effects on aquatic life and humans. MB is traditionally degraded using metal-based catalysts, resulting in high costs. Several organic acids were screened for organo-photooxidative applications against various azo dyes, and ascorbic acid (AA), also known as vitamin C, was found to be best for degradation due to its high photooxidative activity. It is an eco-friendly, edible, and efficient photooxidative material...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496978/phytochemical-screening-in-silico-molecular-docking-adme-properties-and-in-vitro-antioxidant-anticancer-and-antidiabetic-activity-of-marine-halophyte-suaeda-maritima-l-dumort
#3
JOURNAL ARTICLE
Sampath Manojkumar, Murugesan Thandeeswaran, Sathiya Kamatchi Thangavel, Annavi Arjunan, Manickam Muthuselvam, Giriraj Kalaiarasi, Kapildev Gnanajothi
Medicinally valuable components derived from natural resources are highly desirable as prospective alternatives to synthetic drugs to treat fatal diseases, such as cancer and diabetes mellitus. Suaeda maritima (L.) Dumort ( Amaranthaceae ) ( S. maritima ) is a halophyte plant that can thrive in saline environments and possesses excellent medicinal properties. Hence, for the present investigation, S. maritima has been chosen, and its phytochemical constituents have been extracted utilizing various solvents, including hexane, acetone, and methanol, and identified by GC-MS, LC-MS, and HPLC analyses...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496935/biological-activities-of-galanthus-fosteri-extracts-first-demonstration-of-the-interaction-between-chlorogenic-acid-and-dna-ligase-by-molecular-docking
#4
JOURNAL ARTICLE
Safiye Elif Korcan, Nevin Çankaya, İbrahim Bulduk, Gencer Güvercin, Şah İsmail Çivi
Within the Amaryllidaceae family, the bulbous plant species Galanthus fosteri ( G. fosteri ) belongs to the Galanthus genus. Alkaloids with a broad variety of biological functions are typically found in the flora of this family. The G. fosteri plant's organs' antioxidant activity, antibacterial impact, and antimicrobial qualities were examined in this study. Total flavonoid contents (TFC) and total phenolic contents (TPC) of plant extracts were measured with spectrophotometric methods, and antioxidant activity was determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging technique...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496007/acceleration-of-benzo-a-pyrene-induced-colon-carcinogenesis-by-western-diet-in-a-rat-model-of-colon-cancer
#5
JOURNAL ARTICLE
Kelly L Harris, Kenneth J Harris, Leah D Banks, Samuel E Adunyah, Aramandla Ramesh
Colorectal cancer (CRC) is the third leading cause of cancer-related mortalities in the USA and around 52,550 people were expected to die from this disease by December 2023. The objective of this study was to investigate the effect of diet type on benzo(a)pyrene [B(a)P]-induced colon cancer in an adult male rat model, the Polyposis In the Rat Colon (PIRC) kindred type. Groups of PIRC rats (n = 10) were fed with AIN-76A regular diet (RD) or Western diet (WD) and received 25, 50 and 100 µg B(a)P/kg body wt...
2024: Current research in toxicology
https://read.qxmd.com/read/38495616/scaling-the-process-chemistry-of-a-covid-19-antiviral-pharmaceutical-down-for-a-multistep-synthesis-experiment-in-the-undergraduate-teaching-laboratory
#6
JOURNAL ARTICLE
Andrew J Wommack, Aaliyah B Holloway, Kaitlyn A Stallings, Pamela M Lundin
Molnupiravir is an orally bioavailable direct acting antiviral agent that received emergency use authorization in late 2021 from the FDA for the treatment of patients with mild, moderate, or severe COVID-19. This prodrug is metabolized into a ribonucleoside that is incorporated into the viral RNA during replication. Its tautomerization between cytidine- and uridine-like forms ultimately causes multiple irreversible errors in the genetic code of the virus, which prevents successful viral replication. There are multiple process chemistry routes for molnupiravir synthesis published in the literature that attempt to maximize synthetic yield while minimizing cost and waste, which are goals similar to those of an implementable educational laboratory experiment for the teaching laboratory...
March 12, 2024: Journal of Chemical Education
https://read.qxmd.com/read/38495362/in-silico-molecular-docking-approach-to-identify-potential-antihypertensive-compounds-from-ajuga-integrifolia-buch-ham-ex-d-don-armagusa
#7
JOURNAL ARTICLE
Fekade Beshah Tessema, Yilma Hunde Gonfa, Tilahun Belayneh Asfaw, Mesfin Getachew Tadesse, Rakesh Kumar Bachheti
BACKGROUND: Ajuga integrifolia (Armagusa) is used as a decoction to treat high blood pressure and diabetes, widely in Ethiopia. Specific compounds for anti-hypertension activity were not identified so far. This study aims to provide a scientific basis for the therapeutic use of A. integrifolia as an antihypertension agent. METHODS: In silico studies were used to evaluate the antihypertensive components of A. integrifolia . Flavonoids identified using HPLC analysis and iridoid glycosides isolated from A...
2024: Advances and Applications in Bioinformatics and Chemistry: AABC
https://read.qxmd.com/read/38495097/optimization-and-preparation-of-a-compound-cod-liver-oil-film-former-agent-an-orthogonal-design
#8
JOURNAL ARTICLE
Yao He, Ying Zhang, Zheng Li
Background: Cod liver oil has anti-inflammatory properties and could help regulate recurrent aphthous stomatitis (RAS). An orthogonal experiment was used to evaluate and improve the dosage form of compound cod liver oil, which has replaced the previously used liniment preparation based on film method. Methods: An orthogonal experiment was adopted, and the appearance and film-forming time of the film coating agents were used as indicators. The optimal ratio in the preparation process for the compound cod liver oil film agent was then optimized...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38494630/shrimp-cultured-in-low-salt-saline-alkali-water-has-a-better-amino-acid-nutrition-and-umami%C3%A2-comparison-of-flavors-between-saline-alkali-water-and-seawater-cultured-litopenaeus-vannamei
#9
JOURNAL ARTICLE
Kangxiang Qin, Weihao Feng, Zhaoxiong Ji, Xiaosong Jiang, Yun Hu, Yuntao Li, Chenxi Che, Chunlin Wang, Changkao Mu, Huan Wang
The advantages of Litopenaeus vannamei farming in saline-alkali water have gradually attracted attention, but few studies have focused on its flavor. In this study, L. vannamei cultured in saline-alkali water (SS) and ordinary seawater (CS) (both have a breeding time of 120 days) were selected for analysis ( n = 5). High-performance liquid chromatography (HPLC) was used to measure free amino acids and flavoring nucleotides in the muscles of L. vannamei , while the taste activity value (TAV) and equivalent umami concentration (EUC) were used to analyze the degree of umami...
March 17, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38494270/phytocompounds-based-therapeutic-approach-investigating-curcumin-and-green-tea-extracts-on-mcf-7-breast-cancer-cell-line
#10
JOURNAL ARTICLE
Radwa M Fawzy, Amal A Abdel-Aziz, Khalid Bassiouny, Aysam M Fayed
BACKGROUND: Breast cancer (BC) has transcended lung cancer as the most common cancer in the world. Due to the disease's aggressiveness, rapid growth, and heterogeneity, it is crucial to investigate different therapeutic approaches for treatment. According to the World Health Organization (WHO), Plant-based therapeutics continue to be utilized as safe/non-toxic complementary or alternative treatments for cancer, even in developed countries, regardless of how cutting-edge conventional therapies are...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38494220/structural-elucidation-and-anti-psoriasis-activity-of-a-novel-polysaccharide-from-saussurea-costus
#11
JOURNAL ARTICLE
Xiaobao Gong, Zhipeng Zhang, Xiang Shi, Yurong Zhu, Fawad Ali, Yong Dong, Feng Zhang, Baoshun Zhang
PSCP, a novel water-soluble polysaccharide, was extracted from the root of Saussurea costus and subsequently purified using DEAE-52 cellulose and Sephadax G-50 columns. The elucidation of its structure involved various techniques including HPGPC, FT-IR, HPLC-ELSD, GC-MS, NMR, AFM, and SEM. The results show that PSCP was a homogeneous heteropoly saccharide having molecular weight of 4131 Da and mainly composed of 1-α-D-Glcp-(-2-β-D-Fruf-1-)23 -2-β-D-Fruf. The anti-psoriasis activity of PSCP was evaluated in imiquimod-induced psoriasis in Balb/C mice...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38493905/in-silico-and-in-vivo-study-of-anti-inflammatory-activity-of-morinda-longissima-rubiaceae-extract-and-phytochemicals-for-treatment-of-inflammation-mediated-diseases
#12
JOURNAL ARTICLE
Hafidha Mehallah, Noureddine Djebli, Pham Ngoc Khanh, Nguyen Xuan Ha, Vu Thi Ha, Tran Thu Huong, Do Dinh Tung, Nguyen Manh Cuong
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, the plant Morinda longissima Y.Z.Ruan (Rubiaceae) is used by ethnic people in Vietnam for the treatment of liver diseases and hepatitis. AIM OF THE STUDY: The study was designed to assess the efficacy of the 95% ethanolic extract of Morinda longissima roots (MLE) in experimental immune inflammation. The phytochemical variation of root extract and the chemical structures of natural compounds were also investigated using HPLC-DAD-HR-MS analysis...
March 15, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38493904/ginkgo-biloba-l-exocarp-petroleum-ether-extract-inhibits-methicillin-resistant-staphylococcus-aureus-by-modulating-ion-transport-virulence-and-biofilm-formation-in-vitro-and-in-vivo
#13
JOURNAL ARTICLE
Peng-Wei Wei, Xu Wang, Cong Wang, Ming Chen, Meng-Zhu Liu, Wen-Xia Liu, Yan-Ling He, Guo-Bo Xu, Xiao-He Zheng, Hua Zhang, Hong-Mei Liu, Bing Wang
ETHNOPHARMACOLOGICAL RELEVANCE: As reported in the Ancient Chinese Medicinal Books, Ginkgo biloba L. fruit has been used as a traditional Chinese medicine for the treatment asthma and cough or as a disinfectant. Our previous study demonstrated that G. biloba exocarp extract (GBEE), an extract of a traditional Chinese herb, inhibits the formation of methicillin-resistant Staphylococcus aureus (MRSA) biofilms. However, GBEE is a crude extract that contains many components, and the underlying mechanisms of purified GBEE fractions extracted with solvents of different polarities are unknown...
March 15, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38493684/the-cathodically-pretreated-boron-doped-diamond-electrode-as-an-environmentally-friendly-electrochemical-tool-for-the-detection-and-monitoring-of-mesotrione-in-food-samples
#14
JOURNAL ARTICLE
Aleksandar Mijajlović, Vesna Stanković, Filip Vlahović, Slađana Đurđić, Dragan Manojlović, Dalibor Stanković
Excessive pesticide use can harm human health, making it essential to develop new techniques to monitor hazardous pesticides in food. Our study focuses on detecting mesotrione (MST) using an unmodified boron-doped diamond (BDD) electrode. This was the first application of cathodically pretreated BDD electrode for the detection of MST, based on its oxidation at a high potential value of +1.4 V. We theoretically examined the oxidation mechanism of MST trough the utilization of density functional theory (DFT) methodology...
March 13, 2024: Food Chemistry
https://read.qxmd.com/read/38493529/biocompatibility-of-brazilian-native-yeast-derived-sophorolipids-and-trichoderma-harzianum-as-plant-growth-promoting-bioformulations
#15
JOURNAL ARTICLE
Thiago Moura Rocha, Paulo Ricardo Franco Marcelino, Felipe Antonio Fernandes Antunes, Salvador Sánchez-Muñoz, Júlio César Dos Santos, Silvio Silvério da Silva
The replacement of agrochemicals by biomolecules is imperative to mitigate soil contamination and inactivation of its core microbiota. Within this context, this study aimed at the interaction between a biological control agent such as Trichoderma harzianum CCT 2160 (BF-Th) and the biosurfactants (BSs) derived from the native Brazilian yeast Starmerella bombicola UFMG-CM-Y6419. Thereafter, their potential in germination of Oryza sativa L. seeds was tested. Both bioproducts were produced on site and characterized according to their chemical composition by HPLC-MS and GC-MS for BSs and SDS-PAGE gel for BF-Th...
March 8, 2024: Microbiological Research
https://read.qxmd.com/read/38493310/development-and-validation-of-a-new-high-performance-liquid-chromatography-ultraviolet-assay-for-quantification-of-mitoxantrone-in-plasma-of-balb-c-nu-mice
#16
JOURNAL ARTICLE
Yanru Tao, Hua Zhao, Yujie Xiang, Jin Li, Yanting Li, Jiangling Hu, Hongmei Wang, Xinhui Jiang
The concentration of mitoxantrone in the blood of mice was determined by a high-performance liquid chromatography-ultraviolet method with aloe-emodin as the internal standard. The separation was performed on a Hypersil BDS2 column (4.6 × 250 mm, 5 μm) as the analytical column, the mobile Phase A was acetonitrile, and B was 20-mM potassium dihydrogen phosphate (adding 1% triethylamine and adjusting the pH to 2.8 with phosphoric acid) and 4.6-mM sodium octyl sulfonate. The flow rate was 1...
March 15, 2024: Journal of Chromatographic Science
https://read.qxmd.com/read/38493305/development-and-validation-of-a-new-reversed-phase-hplc-method-for-the-quantitation-of-azithromycin-and-rifampicin-in-a-capsule-formulation
#17
JOURNAL ARTICLE
Foram Patel, Rajendra Kotadiya, Rashmin Patel, Mrunali Patel
This research aimed to develop a new method for simultaneously estimating the presence of azithromycin (AZT) and rifampicin (RIF) in a capsule formulation using reverse-phase high-performance liquid chromatography. The developed method utilized a Gemini column with a 60:40% v/v acetonitrile and potassium dihydrogen phosphate mobile phase, a flow rate of 1 mL/min, and an injection volume of 20 μL. The detection wavelengths of 210 and 254 nm for AZT and RIF, respectively, were used. Validation ensures specificity with a peak purity index > 0...
March 15, 2024: Journal of Chromatographic Science
https://read.qxmd.com/read/38493163/simultaneous-determination-of-bromoxynil-and-mcpa-in-commercial-samples-and-raw-materials-using-reversed-phase-high-performance-liquid-chromatography
#18
JOURNAL ARTICLE
Ahmed Yar, Tariq Mahmood Ansari, Faariah Rehman, Asad Raza, Umair Riaz, Rashid Iqbal, Amal M Al-Mohaimeed, Wedad A Al-Onazi, Muhammad Rizwan
This study encompasses a quick, efficient, repeatable and reproducible analytical method for simultaneous determination of Bromoxynil (3, 5-Dibromo-4-hydroxybenzonitrile) and MCPA (2-methyl-4-chlorophenoxyacetic acid) using RP-HPLC with UV-Detector. Bromoxynil + MCPA is one of the most selective post emergent herbicide formulations for the control of important broad leaf weeds infesting small grains (wheat, barley, oats, rye), conservation reserve program areas and grass grown for seed. Optimum weed control is achieved when Bromoxynil + MCPA is applied to actively growing weed seedlings...
March 16, 2024: BMC chemistry
https://read.qxmd.com/read/38492794/mechanism-interpretation-of-guhan-yangshengjing-for-protection-against-alzheimer-s-disease-by-network-pharmacology-and-molecular-docking
#19
JOURNAL ARTICLE
Suet Cheung, Yuan Zhong, Lei Wu, Xiaomeng Jia, Meng-Qi He, Yongjian Ai, Qisen Jiao, Qionglin Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangshengjing (GHYSJ) is an effective prescription for delaying progression of Alzheimer's disease (AD) based on the ancient Chinese medical classics excavated from Mawangdui Han Tomb. Comprising a combination of eleven traditional Chinese herbs, the precise protective mechanism through which GHYSJ acts on AD progression remains unclear and has significant implications for the development of new drugs to treat AD. AIM OF THE STUDY: To investigate the mechanism of GHYSJ in the treatment of AD through network pharmacology and validate the results through in vitro experiments...
March 14, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38492793/a-study-on-the-anti-senescent-effects-of-flavones-derived-from-prinsepia-utilis-royle-seed-residue
#20
JOURNAL ARTICLE
Junxi Liu, Liping Qu, Feifei Wang, Zaoju Mei, Xinlang Wu, Bo Wang, Haiyang Liu, Li He
ETHNOPHARMACOLOGICAL RELEVANCE: Prinsepia utilis Royle, also known as the Anas fruit, is a unique perennial woody oil plant from Yunnan Province, China. In the ancient texts of Dongba sutras and Yunnan Southern Materia Medica, it has been documented that the local Naxi, Tibetan, and Mosuo communities extensively utilize the root and leaf fruits of green thorns for various purposes. These include treating mild-to-moderate specific dermatitis, moisturising the skin, providing protection against UV damage, aiding childbirth in pregnant women, safeguarding stomach health, reducing the risk of arteriosclerosis, and delaying aging...
March 14, 2024: Journal of Ethnopharmacology
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