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Pharmaceutical Science

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https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#1
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29214696/microemulsions-micelles-and-functional-gels-how-colloid-and-soft-matter-preserve-works-of-art
#2
David Chelazzi, Rodorico Giorgi, Piero Baglioni
Colloid Science provides fundamental knowledge to fields such as pharmaceutical, detergency, paint and food industry. An exciting application is art conservation, which poses a challenge owing to the complex range of interfacial interactions involved in restoring artefacts. Currently, the majority of the most performing and environmentally safe cleaning and consolidation agents for artworks belong to soft matter and colloids. We report here on the development and application of increasingly complex systems, from microemulsions to semi-interpenetrating hydrogels containing such fluids...
December 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29210667/nerolidol-and-its-pharmacological-application-in-treating-neurodegenerative-diseases-a-review
#3
Rusbene Bruno Fonseca De Carvalho, Antonia Amanda Cardoso De Almeida, Neylon Barbosa Campelo, Daniel Ramon Oliveira Dantas Lellis, Livio Cesar Cunha Nunes
BACKGROUND: Research on natural bioactive compounds has increased exponentially over the last decades. The discovery of new phytochemicals that possess pharmaceutical properties is useful in the development of therapeutic alternatives. The nerolidol (3,7,11-trimetil-1,6,10-dodecatrien-3-ol or 3,7,11-trimetildodeca-1,6,10-trien-3-ol) has been extensively studied for its therapeutic potential because of its pharmacological activities in the treatment of neurodegenerative diseases. METHODS: All articles and patents regarding to nerolidol and its pharmacological properties were revised, focusing mainly on the important properties in the treatment of neurodegenerative diseases...
December 6, 2017: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/29205242/refining-tools-to-bridge-the-gap-between-academia-and-chemical-regulation-perspectives-for-wikireach
#4
Marlene Ågerstrand, Mattheus Brenig, Martin Führ, Julian Schenten
Regulatory hazard and risk assessments of chemical substances have to include all reliable and relevant data to be credible and complete. However, screening the literature for appropriate studies and extracting data is burdensome. Therefore, reducing impediments by making data easily and readily accessible to risk assessors could result in more comprehensive hazard and risk assessments. In this paper, we study WikiPharma, a database that aggregates ecotoxicity data for pharmaceuticals, extracted from peer-reviewed studies...
December 5, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29200459/competency-programming-and-emerging-innovation-in-graduate-education-within-schools-of-pharmacy-the-report-of-the-2016-2017-research-and-graduate-affairs-committee
#5
Samuel M Poloyac, Kirsten F Block, Jane E Cavanaugh, Linda P Dwoskin, Russell B Melchert, Ruth E Nemire, James M O'Donnell, Ronny Priefer, Daniel R Touchette
Graduate education in the pharmaceutical sciences is a cornerstone of research within pharmacy schools. Pharmaceutical scientists are critical contributors to addressing the challenges of new drug discovery, delivery, and optimal care in order to ensure improved therapeutic outcomes in populations of patients. The American Association of Colleges of Pharmacy (AACP) charged the 2016-2017 Research and Graduate Affairs Committee (RGAC) to define the competencies necessary for graduate education in the pharmaceutical sciences (Charge 1), recommend collaborative curricular development across schools of pharmacy (Charge 2), recommend AACP programing for graduate education (Charge 3), and provide guidance on emerging areas for innovation in graduate education (Charge 4)...
October 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29199216/development-of-highly-sensitive-analytical-methods-for-biologically-relevant-materials-and-their-pharmaceutical-applications
#6
Hidetoshi Arakawa
One important aspect of analytical chemistry research in the pharmaceutical sciences is the development of diagnostic and therapeutic analyses for disease, and the development of analytical methods for elucidating the causes of disease. I have been focusing on developing a highly sensitive method for measuring trace amounts of specific components in biological samples. This research can be roughly divided into three approaches: the use of immunoassays and DNA hybridization as methods utilizing specific affinities, the use of capillary electrophoresis as a highly sensitive and rapid separation method, and the use of chemiluminescence and bioluminescence reactions...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29199000/research-needs-to-understand-self-management-in-men-with-luts-a-review-and-summary-of-an-niddk-workshop
#7
EDITORIAL
Jenna M Norton, Tamara G Bavendam, William Elwood, Steven J Jacobsen, Steven A Kaplan, John W Kusek, Yining Xie, Robert A Star, Ziya Kirkali
Lower urinary tract symptoms (LUTS) are common in men and impose significant economic, health and quality of life burdens. Despite an expanding view of LUTS etiology and challenges with medical and surgical treatments, LUTS research has continued to focus primarily on surgical or pharmaceutical treatment of urinary tract dysfunction, with little attention to behavioral, cognitive, or social factors. Further, self-management research is relatively underdeveloped in urology, despite its potential to support behavioral, pharmacologic, and surgical treatments for LUTS...
November 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29196435/leaving-the-bench-and-finding-your-foundation
#8
REVIEW
John E Spiro
Scientists who leave the laboratory bench to work for biomedical foundations mobilize and focus resources on the most promising research behind a foundation's mission. They acquire a broad view of a field, interact closely with research scientists at meetings and laboratory visits, and often manage proposal review boards and monitor grant progress. Increasingly, scientists at foundations also have a more active role in catalyzing research: They are involved in organizing targeted workshops, setting research priorities, and directly creating and managing resources for a scientific community...
December 1, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29193409/more-insights-into-the-pharmacological-effects-of-artemisinin
#9
REVIEW
Abdelmajid Zyad, Mounir Tilaoui, Abdeslam Jaafari, Moulay Ali Oukerrou, Hassan Ait Mouse
Artemisinin is one of the most widely prescribed drugs against malaria and has recently received increased attention because of its other potential biological effects. The aim of this review is to summarize recent discoveries of the pharmaceutical effects of artemisinin in basic science along with its mechanistic action, as well as the intriguing results of recent clinical studies, with a focus on its antitumor activity. Scientific evidence indicates that artemisinin exerts its biological activity by generating reactive oxygen species that damage the DNA, mitochondrial depolarization, and cell death...
November 28, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29189770/langmuir-blodgett-nanotemplates-for-protein-crystallography
#10
Eugenia Pechkova, Claudio Nicolini
The new generation of synchrotrons and microfocused beamlines has enabled great progress in X-ray protein crystallography, resulting in new 3D atomic structures for proteins of high interest to the pharmaceutical industry and life sciences. It is, however, often still challenging to produce protein crystals of sufficient size and quality (order, intensity of diffraction, radiation stability). In this protocol, we provide instructions for performing the Langmuir-Blodgett (LB) nanotemplate method, a crystallization approach that can be used for any protein (including membrane proteins)...
December 2017: Nature Protocols
https://www.readbyqxmd.com/read/29184843/the-performance-implications-of-pharmacy-information-system-at-the-university-teaching-hospitals-of-shiraz-iran-cluster-approach
#11
Saeede Bayati, Peivand Bastani, Zahra Mahmoodzade Sagheb, Sara Jamalabadi, Mahnaz Samadbeik
Pharmacy information system (PIS) is becoming vital in assisting pharmacists to do their responsibilities. The aim of this study was to identify the current PIS implications in teaching hospitals affiliated with Shiraz University of Medical Science. This cross-sectional study was conducted in teaching hospitals affiliated with Shiraz University of Medical Science over the year 2016. Data were collected by observing the PIS as well as interviewing its users based on the researcher-made checklist. The checklist was prepared based on reviewing the Persian and English literature and its content validity was approved by the experts...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29181493/neflamapimod-clinical-phase-2b-ready-oral-small-molecule-inhibitor-of-p38%C3%AE-to-reverse-synaptic-dysfunction-in-early-alzheimer-s-disease
#12
J Alam, K Blackburn, D Patrick
Neflamapimod (previously code named VX-745) is a clinical phase 2b-ready highly specific inhibitor of the intra-cellular enzyme p38 mitogen activated protein kinase alpha ("p38α") that is being developed as a disease-modifying drug for Alzheimer's disease (AD) that acts via targeting synaptic dysfunction. Neflamapimod was discovered through a proprietary structure-based drug discovery platform at Vertex Pharmaceuticals, and developed previously by Vertex through to phase 2a in rheumatoid arthritis. EIP Pharma licensed the compound in 2014 for development and commercialization as a treatment of central nervous system (CNS) disorders...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29173031/probing-the-interaction-of-silver-nanoparticles-with-tau-protein-and-neuroblastoma-cell-line-as-nervous-system-models
#13
Sara Rahmani, Leila Mogharizadeh, Farnoosh Attar, Seyed Mahdi Rezayat, Seyyedeh Elaheh Mousavi, Mojtaba Falahati
Interestingly pharmaceutical sciences are using nanoparticles (NPs) to design and develop nanomaterials-based drugs. However, up to recently, it has not been well realized that NPs themselves may impose risks to the biological systems. In this study, the interaction of silver nanoparticles (AgNPs) with tau protein and SH-SY5Y neuroblastoma cell line, as potential nervous system models, was examined with a range of techniques including intrinsic fluorescence spectroscopy, circular dichroism (CD) spectroscopy, 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and acridine orange/ethidium bromide (AO/EB) dual staining method...
November 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29168557/probiotics-for-vulvovaginal-candidiasis-in-non-pregnant-women
#14
REVIEW
Huan Yu Xie, Dan Feng, Dong Mei Wei, Ling Mei, Hui Chen, Xun Wang, Fang Fang
BACKGROUND: Vulvovaginal candidiasis (VVC) is estimated to be the second most common form of infection after bacterial vaginosis. The ability of probiotics in maintaining and recovering the normal vaginal microbiota, and their potential ability to resist Candidas give rise to the concept of using probiotics for the treatment of VVC. OBJECTIVES: To assess the effectiveness and safety of probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29160494/managing-febrile-neutropenia-in-adult-cancer-patients-an-integrative-review-of-the-literature
#15
Juliana Nunes Ferreira, Lury Renata Barbosa Ribeiro Correia, Renata Moreira de Oliveira, Silvia Naomi Watanabe, João Francisco Possari, Antônio Fernandes Costa Lima
OBJECTIVE: To analyze the interventions performed by health professionals with a view to managing chemotherapy-induced febrile neutropenia. METHOD: Integrative literature review, the sample of 12 primary articles was selected from the following databases: LILACS, SciELO, BVS, PubMed, CINAHL and Web of Science. RESULTS: There was a prevalence of studies, realized by doctors, focused on pharmacological treatment and on the association of methods for greater diagnostic accuracy of febrile neutropenia...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29158037/quantitative-imaging-dosimetry-and-metrology-where-do-national-metrology-institutes-fit-in
#16
A J Fenwick, J L Wevrett, K M Ferreira, A M Denis-Bacelar, A P Robinson
In External Beam Radiotherapy, National Metrology Institutes (NMIs) play a critical role in the delivery of accurate absorbed doses to patients undergoing treatment. In contrast for nuclear medicine the role of the NMI is less clear and although significant work has been done in order to establish links for activity measurement, the calculation of administered absorbed doses is not traceable in the same manner as EBRT. Over recent decades the use of novel radiolabelled pharmaceuticals has increased dramatically...
November 11, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29156194/editorial-special-supplement-of-the-european-journal-of-pharmaceutical-sciences-on-the-occasion-of-the-retirement-of-professor-meindert-danhof-as-professor-of-pharmacology-at-leiden-university
#17
EDITORIAL
Koos Burggraaf, Douwe Breimer, Piet van der Graaf, Liesbeth de Lange
No abstract text is available yet for this article.
November 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29151208/strategies-for-efficient-sample-preparation-for-dynamic-nuclear-polarization-solid-state-nmr-of-biological-macromolecules
#18
Boris Itin, Ivan V Sergeyev
Solid-state NMR (SSNMR) is a powerful tool for the elucidation of structure and dynamics in biological macromolecules. Over the years, SSNMR spectroscopists have developed an array of techniques enabling the measurement of internuclear correlations, distances, and torsional angles; these have been applied to the study of a number of biological systems that are difficult to study by X-ray crystallography and solution NMR, including key biological targets such as membrane proteins and amyloid fibrils. Applications of SSNMR to other topic areas, including materials science, pharmaceuticals, and small molecules, have also flourished in recent years...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29149556/evaluating-force-field-london-dispersion-coefficients-using-the-exchange-hole-dipole-moment-model
#19
Mohamad Mohebifar, Erin R Johnson, Christopher N Rowley
London dispersion interactions play an integral role in materials science and biophysics. Force fields for atomistic molecular simulations typically represent dispersion interactions by the 12-6 Lennard-Jones potential, using empirically-determined parameters. These parameters are generally underdetermined and there is no straightforward way to test if they are physically realistic. Alternatively, the exchange-hole dipole moment (XDM) model from density-functional theory predicts atomic and molecular London dispersion coefficients from first principles, providing an innovative strategy to validate the dispersion terms of molecular-mechanical force fields...
November 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29148357/cuts-and-the-cutting-edge-british-science-funding-and-the-making-of-animal-biotechnology-in-1980s-edinburgh
#20
Dmitriy Myelnikov
The Animal Breeding Research Organisation in Edinburgh (ABRO, founded in 1945) was a direct ancestor of the Roslin Institute, celebrated for the cloning of Dolly the sheep. After a period of sustained growth as an institute of the Agricultural Research Council (ARC), ABRO was to lose most of its funding in 1981. This decision has been absorbed into the narrative of the Thatcherite attack on science, but in this article I show that the choice to restructure ABRO pre-dated major government cuts to agricultural research, and stemmed from the ARC's wish to prioritize biotechnology in its portfolio...
December 2017: British Journal for the History of Science
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