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https://www.readbyqxmd.com/read/29451603/from-medicinal-chemistry-to-human-health-current-approaches-to-drug-discovery-for-cancer-and-neglected-tropical-diseases
#1
Leonardo G Ferreira, Glaucius Oliva, Adriano D Andricopulo
Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprecedentedly demanded the development of up-to-date computational approaches, such as bio- and chemo-informatics. These tools have been pivotal to catalyzing the ever-increasing amount of data generated by the molecular sciences, and to converting the data into insightful guidelines for use in the research pipeline...
February 15, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29451391/the-future-of-lc-ms-for-pharmaceutical-analysis-an-interview-with-jun-qu
#2
Jun Qu
Jun Qu speaks to Sankeetha Nadarajah, Editor of Bioanalysis: Jun Qu is the group leader of the proteomics and pharmaceutical analysis lab of SUNY-Buffalo (NY, USA) and a Professor in the Department of Pharmaceutical Sciences. His research is focused on the study of Clinical and Pharmaceutical Proteomics and Pharmaceutical Analysis using LC-MS-based strategies. His research programs include high-resolution and large-scale expression profiling of pathological proteomes, for the discovery of novel disease/therapeutics biomarkers using gel-free proteomic methods; sensitive identification, localization and quantification of post-translational modifications in tissue proteomes such as these in myocardium, using novel anti-PTM affinity capture and alternating Collision-induced dissociation/Electron transfer dissociation to obtain abundant PTM information; targeted investigation of marker proteins that are of high interests for clinical and pharmaceutical study, using highly sensitive nano-LC/SRM-based methods; and highly sensitive and accurate investigation of the PK of biotherapeutics using LC-MS...
February 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29445628/medicinal-properties-of-adiantum-capillus-veneris-linn-in-traditional-medicine-and-modern-phytotherapy-a-review-article
#3
REVIEW
Sahar Dehdari, Homa Hajimehdipoor
Background: Adiantum capillus-veneris Linn (Maidenhair fern) is an herb belonging to the family Pteridaceae. It is named as " Pare-siavashan " in medical and pharmaceutical textbooks of Iranian Traditional Medicine. The fronds of Maidenhair fern were mainly administrated by ancient physicians as single medicine or in combination with other plants in multi-herbal formulations for curing different diseases. Because of different chemical compositions, the herb fronds were also assessed for its numerous pharmacological effects...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29444994/life-cycle-assessment-of-cleanroom-coveralls-reusable-and-disposable
#4
Eric Vozzola, Michael Overcash, Evan Griffing
Cleanroom garments serve a critical role in such industries as pharmaceuticals, life sciences, and semiconductor manufacturing. These textiles are available in reusable and disposable alternatives. In this report, the environmental sustainability of cleanroom coveralls is examined using life cycle assessment technology. The complete supply chain, manufacture, use, and end-of-life phases for reusable and disposable cleanroom coveralls are compared on a cradle-to-end-of-life cycle basis. Three industry representative coveralls are examined: a reusable woven polyethylene terephthalate (PET) coverall, a disposable flash spunbonded high density polyethylene (HDPE) coverall, and a disposable spunbond-meltblown-spunbond polypropylene (SMS PP) coverall...
February 14, 2018: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29436839/enhancing-the-spreading-behavior-on-pulmonary-mucus-mimicking-subphase-via-catanionic-surfactant-solutions-towards-effective-drug-delivery-through-the-lungs
#5
Gokce Alp, Nihal Aydogan
Effective and efficient spreading of drug formulations on the pulmonary mucosal layer is key to successful delivery of therapeutics through the lungs. Pulmonary mucus layer, which covers the airway surface, acts as a barrier against therapeutic agents, especially in the case of chronic lung diseases due to increased thickness and viscosity of mucus. Therefore, spreading of the drug formulations on the airways gets harder. Although spreading experiments have been conducted with different types of formulations on mucus-mimicking subphases, a highly effective formulation is yet to be discovered...
February 13, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29436260/treatment-patterns-and-associated-health-care-costs-before-and-after-treatment-initiation-among-pulmonary-arterial-hypertension-patients-in-the-united-states
#6
Charles D Burger, A Burak Ozbay, Howard M Lazarus, Ellen Riehle, Leslie B Montejano, Gregory Lenhart, R James White
BACKGROUND: Despite multiple treatment options, the prognosis of pulmonary arterial hypertension (PAH) remains poor. PAH patients experience a high economic burden due to comorbidities, hospitalizations, and medication costs. Although combination therapy has been shown to reduce hospitalizations, the relationship between treatment, health care utilization, and costs remains unclear. OBJECTIVE: To provide a characterization of health care utilization and costs in real-world settings by comparing periods before and after initiating PAH-specific treatment...
February 13, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29435904/performance-of-the-population-bioequivalence-pbe-statistical-test-using-an-ipac-rs-database-of-delivered-dose-from-metered%C3%A2-dose-inhalers
#7
Beth Morgan, Stephanie Chen, David Christopher, Göran Långström, Christopher Wiggenhorn, Elise Burmeister Getz, Hayden Beresford, Thomas Hoffelder, Daniela Acerbi, Stephen Andrews, Mark Berry, Monisha Dey, Keyur Joshi, Mary McKenry, Marisa Pertile, Helen Strickland, David Wilcox, Svetlana Lyapustina
This article reports performance characteristics of the population bioequivalence (PBE) statistical test recommended by the US Food and Drug Administration (FDA) for orally inhaled products. A PBE Working Group of the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) assembled and considered a database comprising delivered dose measurements from 856 individual batches across 20 metered dose inhaler products submitted by industry. A review of the industry dataset identified variability between batches and a systematic lifestage effect that was not included in the FDA-prescribed model for PBE...
February 12, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29432499/industry-corrupted-psychiatric-trials
#8
REVIEW
Jay D Amsterdam, Leemon B McHenry, Jon N Jureidini
The goal of this paper is to expose the research misconduct of pharmaceutical industry sponsored clinical trials via three short case studies of corrupted psychiatric trials that were conducted in the United States. We discuss the common elements that enable the misrepresentation of clinical trial results including ghostwriting for medical journals, the role of key opinion leaders as co-conspirators with the pharmaceutical industry and the complicity of top medical journals in failing to uphold standards of science and peer review...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29428928/new-concepts-of-chronic-pain-and-the-potential-role-of-complementary-therapies
#9
Ken Wojcikowski, Vanessa J Vigar, Christopher J Oliver
Context • The mechanisms of chronic pain involve complex neuroplastic changes at all 3 orders of neurons involved in the transmission of pain as well as changes in the descending inhibitory pathway. Although traditional pharmaceutical therapies have some efficacy, substantial scope exists for a new model of individualized therapy, tailored to the specific response of each patient. Because changes occur at all levels of the pain pathway, successful treatment may require a combination of therapies with different mechanisms of action...
March 10, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29427976/predictive-ecotoxicity-of-moa-1-of-organic-chemicals-using-in-silico-approaches
#10
Luana de Morais E Silva, Mateus Feitosa Alves, Luciana Scotti, Wilton Silva Lopes, Marcus Tullius Scotti
Persistent organic products are compounds used for various purposes, such as personal care products, surfactants, colorants, industrial additives, food, pesticides and pharmaceuticals. These substances are constantly introduced into the environment and many of these pollutants are difficult to degrade. Toxic compounds classified as MoA 1 (Mode of Action 1) are low toxicity compounds that comprise nonreactive chemicals. In silico methods such as Quantitative Structure-Activity Relationships (QSARs) have been used to develop important models for prediction in several areas of science, as well as aquatic toxicity studies...
February 7, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29425669/editorial-invitation-to-become-a-reviewer-for-the-journal-of-pharmaceutical-sciences
#11
EDITORIAL
Ronald T Borchardt
No abstract text is available yet for this article.
February 6, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29422861/the-turkish-medicines-and-medical-devices-agency-comparison-of-its-registration-process-with-australia-canada-saudi-arabia-and-singapore
#12
Emel Mashaki Ceyhan, Hakki Gürsöz, Ali Alkan, Hacer Coşkun, Oğuzhan Koyuncu, Stuart Walker
Introduction: Regulatory agency comparisons can be of more value and facilitate improvements if conducted among countries with common challenges and similar health agency characteristics. A study was conducted to compare the registration review model used by the Turkish Medicines and Medical Devices Agency (Türkiye Ilaç ve Tibbi Cihaz Kurumu; TITCK) with those of four similar-sized regulatory agencies to identify areas of strength and those requiring further improvement within the TITCK in relation to the review process as well as to assess the level of adherence to good review practices (GRevP) in order to facilitate the TITCK progress toward agency goals...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29419330/organ-based-drug-delivery
#13
Mohammad Alsaggar, Dexi Liu
The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limit adequate drug disposition at the site of action and by off-target drug distribution to undesired tissues, which together result in the reduced effectiveness and increased side effects of therapeutic agents...
February 8, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29416207/contribution-of-arabic-medicine-and-pharmacy-to-the-development-of-health-care-protection-in-bosnia-and-herzegovina-the-second-part
#14
Izet Masic
After the collapse of the Arab rule, the Arab territorial expanses and cultural heritage were taken over by the Turks. Although scientific progress in the Turkish period slowed down due to numerous unfavorable political-economic and other circumstances. Thanks to the Turks, Arabic culture and useful Islamic principles expanded to the territory of our homeland of Bosnia and Herzegovina (B&H). Significant role in the transfer of Arabic pharmaceutical knowledge was also attributed to the Sephardic Jews who, with their arrival, continued to perform their attar activities, which were largely based on Arab achievements...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29410156/backstories-on-the-u-s-opioid-epidemic-good-intentions-gone-bad-an-industry-gone-rogue-and-watch-dogs-gone-to-sleep
#15
REVIEW
Richard deShazo, McKenzie Johnson, Ike Eriator, Kathryn Rodenmeyer
Epidemics of opioid use are old news in the United States, but an epidemic that kills over 200,000 Americans is not. A multiplicity of intertwined factors have brought us to this place. From 30,000 feet, it is the story of good intentions gone bad, a drug industry gone rogue, and government watch dog agencies gone to sleep. At ground level, it is the story of physicians unfamiliar with addictive drugs and drug addiction, new long acting opioids deceptively marketed, cheap black tar heroin, encouragement to use opioids for chronic non-cancer pain by professional organizations with conflicts of interest and without science, a culture intolerant to pain and tolerant to drug use, and the greedy response of the pharmaceutical industry and drug cartels to an expanding market opportunity...
January 31, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29406840/prostacyclin-use-among-patients-with-pulmonary-arterial-hypertension-in-the-united-states-a-retrospective-analysis-of-a-large-health-care-claims-database
#16
Charles D Burger, Janis A Pruett, Cassandra A Lickert, Ariel Berger, Brian Murphy, William Drake
BACKGROUND: Prostacyclins play an important role in the management of pulmonary arterial hypertension (PAH). Intravenous prostacyclin was the first disease-specific treatment for patients with PAH. Subcutaneous and nonparenteral (oral or inhaled) formulations have subsequently become available. However, data are lacking on how these different prostacyclin formulations are being used in clinical practice. OBJECTIVES: To (a) conduct retrospective analyses of a large U...
December 18, 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29406837/optimization-of-medication-use-at-accountable-care-organizations
#17
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
May 30, 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29402116/rhazes-a-pioneer-in-contribution-to-trials-in-medical-practice
#18
REVIEW
Farzaneh Ghaffari, Mohsen Naseri, Razieh Jafari Hajati, Arman Zargaran
Medical history explains that Persian physicians used scientific methods based on clinical experiences and observations for treatment from pre-Islamic time (before 637 AD) and centuries later (in the Islamic era). Rhazes was one of the Persian physicians acknowledged as a pharmacist, chemist and prominent scientific writer on various subjects of medicine and philosophy. In this study, we aimed to investigate clinical experiences, as well as the ethical and critical views of Rhazes in medical practice. Rhazes promoted ethics in the medical profession...
December 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/29400625/undisclosed-conflicts-of-interests-among-biomedical-textbook-authors
#19
Brian J Piper, Drew A Lambert, Ryan C Keefe, Phoebe U Smukler, Nicolas A Selemon, Zachary R Duperry
BACKGROUND: Textbooks are a formative resource for health care providers during their education and are also an enduring reference for pathophysiology and treatment. Unlike the primary literature and clinical guidelines, biomedical textbook authors do not typically disclose potential financial conflicts of interest (pCoI). The objective of this study was to evaluate whether the authors of textbooks used in the training of physicians, pharmacists, and dentists had appreciable undisclosed pCoI in the form of patents or compensation received from pharmaceutical or biotechnology companies...
February 5, 2018: AJOB Empirical Bioethics
https://www.readbyqxmd.com/read/29399533/pathogenesis-of-thrombosis-cellular-and-pharmacogenetic-contributions
#20
REVIEW
Dileep D Monie, Emma P DeLoughery
Our understanding of thrombosis formation has evolved significantly ever since physician Rudolf Virchow proposed his "triad" theory in 1856. Modern science has elucidated the mechanisms of stasis, hypercoagulability, and endothelial dysfunction. Today, we have a firm understanding of the key molecular factors involved in the coagulation cascade and fibrinolytic system, as well as the underlying genetic influences. This knowledge of cellular and genetic contributors has been translated into diverse pharmaceutical interventions...
December 2017: Cardiovascular Diagnosis and Therapy
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