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https://www.readbyqxmd.com/read/28078991/vegetable-organosulfur-compounds-and-their-health-promoting-effects
#1
Spyridon A Petropoulos, Francesco Di Gioia, Georgia Ntatsi
BACKGROUND: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the natural compounds and their medicinal and bioactive properties. Organosulfur compounds are present in many plants and their bioactive properties have been used in folk and traditional medicine throughout the centuries. Not until recently, modern science confirmed and revealed the chemical compounds that are responsible for these properties, the chemistry involved in their biosynthesis and the main mechanisms of action...
January 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28076528/the-brief-life-of-norplant%C3%A2-in-brazil-controversies-and-reassemblages-between-science-society-and-state
#2
Ana Cristina de Lima Pimentel, Cláudia Bonan Jannotti, Paula Gaudenzi, Luiz Antonio da Silva Teixeira
Norplant® is the brand name of the world's first registered subdermal hormonal contraceptive implant, developed by the laboratories of the Population Council, an international organisation working in the area of fertility and population growth. The article revisits the trajectory of this contraceptive in Brazil from its arrival through clinical trials to its eventual ban in 1986 by the Brazilian regulatory agency responsible for approving medications at the time. Its circulation generated controversies related to research practices, side effects and political uses of the drug as a birth control method...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28074749/students-use-stamp-out-program-to-advance-seniors-knowledge-of-drug-misuse
#3
Gabrielle Cozzi, Elisa Torres, Robert G Wahler
: This program assessed the impact of student presentations on 30 seniors and sought to improve their knowledge of prescription drug misuse and abuse. The six pharmacy students used the ASCP Foundation's "STAMP Out Prescription Drug Misuse and Abuse Tool Kit." Information presented to senior audiences included descriptions of drug misuse and abuse and preventive measures to uphold medication safety. Students assessed seniors' prior knowledge about the topics through audience participation...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28061902/disposal-practices-of-unused-and-expired-pharmaceuticals-among-general-public-in-kabul
#4
Mohammadk Bashaar, Vijay Thawani, Mohamed Azmi Hassali, Fahad Saleem
BACKGROUND: Most of the medicine users remain unaware about the disposal of unused or expired medicines. The aim of this study was to know the disposal practices of unused and expired medicines among the general public in Kabul. METHODS: This was a descriptive, cross-sectional survey, conducted through face-to-face interviews using prevalidated structured questionnaire. Returned questionnaires were double-checked for accuracy. Statistical Package for Social Science (SPSS) version 23 was used for statistical analysis...
January 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28053077/animal-research-the-3rs-and-the-internet-of-things-opportunities-and-oversight-in-international-pharmaceutical-development
#5
Steven M Niemi, Gail F Davies
Stages of drug (and vaccine) discovery and evaluation that involve laboratory animals increasingly occur via scientific collaborations across national borders and continents. Many of these research collaborations are between asset-rich institutions and others in less wealthy parts of the world. The care and use of laboratory animals in geographically disparate locations introduces new complexities, such as different oversight requirements and available resources, as well as diverse organizational and cultural milieus...
December 2016: ILAR Journal
https://www.readbyqxmd.com/read/28053076/opportunities-to-apply-the-3rs-in-safety-assessment-programs
#6
Fiona Sewell, Joanna Edwards, Helen Prior, Sally Robinson
Before a potential new medicine can be administered to humans it is essential that its safety is adequately assessed. Safety assessment in animals forms an integral part of this process, from early drug discovery and initial candidate selection to the program of recommended regulatory tests in animals. The 3Rs (replacement, reduction, and refinement of animals in research) are integrated in the current regulatory requirements and expectations and, in the EU, provide a legal and ethical framework for in vivo research to ensure the scientific objectives are met whilst minimizing animal use and maintaining high animal welfare standards...
December 2016: ILAR Journal
https://www.readbyqxmd.com/read/28053064/scientific-knowledge-and-technology-animal-experimentation-and-pharmaceutical-development
#7
Lewis B Kinter, Joseph J DeGeorge
Human discovery of pharmacologically active substances is arguably the oldest of the biomedical sciences with origins >3500 years ago. Since ancient times, four major transformations have dramatically impacted pharmaceutical development, each driven by advances in scientific knowledge, technology, and/or regulation: (1) anesthesia, analgesia, and antisepsis; (2) medicinal chemistry; (3) regulatory toxicology; and (4) targeted drug discovery. Animal experimentation in pharmaceutical development is a modern phenomenon dating from the 20th century and enabling several of the four transformations...
December 2016: ILAR Journal
https://www.readbyqxmd.com/read/28049901/improvement-of-clinical-skills-through-pharmaceutical-education-and-clinical-research
#8
Junko Ishizaki
 Professors and teaching staff in the field of pharmaceutical sciences should devote themselves to staying abreast of relevant education and research. Similarly those in clinical pharmacies should contribute to the advancement of pharmaceutical research and the development of next generation pharmacists and pharmaceuticals. It is thought that those who work in clinical pharmacies should improve their own skills and expertise in problem-finding and -solving, i.e., "clinical skills". They should be keen to learn new standard treatments based on the latest drug information, and should try to be in a position where collecting clinical information is readily possible...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28049892/maintenance-of-clinical-expertise-and-clinical-research-by-the-clinical-professors-at-gifu-pharmaceutical-university
#9
Tomoya Tachi, Yoshihiro Noguchi, Hitomi Teramachi
 The clinical professors at Gifu Pharmaceutical University (GPU) provide pharmaceutical services at GPU Pharmacy, Gifu University Hospital, and Gifu Municipal Hospital to keep their clinical skills up-to-date; they also perform clinical research in collaboration with many clinical institutes. The Laboratory of Clinical Pharmacy is part of the Department of Pharmacy Practice and Science, to which the clinical professors belong, and is composed of three clinical professors (a professor, an associate professor, and an assistant professor)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28049891/development-of-cellular-and-tissue-based-products-for-retinal-regenerative-medicine
#10
Fumitaka Osakada
 Since the discovery of induced pluripotent stem cells (iPSCs) generation, much progress has been made in the fields of medical and pharmaceutical research, such as cell transplantation therapy. We have generated retinal cells and tissues, including retinal pigment epithelia (RPE), from human iPSCs. The ability to produce iPSCs from patients allows for autologous transplantation without causing immune rejection. The autologous transplantation of iPSC-derived retinal pigment epithelial sheets to a patient with age-related macular degeneration was carried out in Japan in 2014 as a first-in-human clinical study...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28045654/information-systems-in-clinical-pharmacy-applied-to-parenteral-nutrition-management-and-traceability-a-systematic-review
#11
Josefa Martínez Gabarrón, Javier Sanz-Valero, Carmina Wanden-Berghe
OBJECTIVE: To review the scientific literature on clinical pharmacy information systems applied to parenteral nutrition (PN) management and traceability. METHOD: A systematic review of the documents retrieved from the MEDLINE (PubMed), Web of Science, Scopus, Cochrane Library, International Pharmaceutical Abstracts (IPA) and Google Scholar databases up to May, 2016. The terms used, as descriptors and free text, were: "Parenteral Nutrition" and "Drug Information Services"...
January 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28041853/stem-cells-in-male-sexual-dysfunction-are-we-getting-somewhere
#12
REVIEW
Mohammad Ayodhia Soebadi, Uros Milenkovic, Emmanuel Weyne, Fabio Castiglione, Maarten Albersen
INTRODUCTION: Stem cells for sexual disorders are steadily being introduced into clinical trials. Two conditions of importance are the main target for this line of treatment, especially when regarding the wide array of translational and basic science highlighting the potential advantages of regenerative therapy: erectile dysfunction (ED) and more recently Peyronie disease (PD). Cellular therapy offers a treatment modality that might reverse disease progression. It would be used in a curative setting, in contrast to other pharmaceutical agents that are currently available...
December 29, 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28038483/a-new-museum-within-the-croatian-academy-of-sciences-and-arts-and-the-first-of-its-kind-in-croatia-the-croatian-museum-of-medicine-and-pharmacy
#13
EDITORIAL
Silvija Brkić Midžić
One decade has passed since the Croatian Academy of Sciences and Arts initiated the foundation of the Croatian Museum of Medicine and Pharmacy, providing it with the location of 300m in Gundulićeva Street 24 in Zagreb. The foundation of the Museum was the Collection of the History of Medicine and Pharmacy which was in safekeeping of the Division for the History of Medical Sciences of the Croatian Academy of Sciences and Arts in Zagreb for more than fifty years. It was put together by combining the materials from two collections: the pharmaceutical-historical collection in Zagreb, which subsequently became the collection of the Institute for the History of Pharmacy, and the one of the Croatian Medical History Museum, which was established in 1944 within the Croatian Medical Association...
December 2016: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/28035041/pharma-partnering-other-people-s-science
#14
Christian Hofmann
Partnering is an ideal field if someone is seeking to move from a scientific to a more business-oriented discipline. Partnering's goal is to identify and acquire external innovation. These discoveries are then included in a company's pipeline and help bring novel treatments to patients. Advanced scientific training is essential in the identification and evaluation of these external assets. Here I describe how partnering works in a pharmaceutical company and offer advice on how to make a successful transition from a PhD program to a business career...
January 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28031978/translational-research-needs-us-to-go-back-to-basics-and-collaborate-interview-with-lars-sundstrom
#15
Lars Sundstrom
Lars Sundstrom is Director of Enterprise and Translation at the West of England Academic Health Sciences Network [1] (UK), a Professor of Practice in Translational Medicine and Co-Director of the Elizabeth Blackwell Institute for Health Research at Bristol University [2] (UK), and an honorary Professor of Medicine at Cardiff University (UK). He has extensive experience in translational medicine and clinical neurosciences, holding positions at several eminent universities. He has also held executive and board-level positions at several SMEs, developing new therapeutics for neurological conditions and tools for drug discovery...
September 2016: Future Science OA
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#16
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
: Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27999118/effect-of-pretreatment-with-oral-contraceptives-and-progestins-on-ivf-outcomes-in-women-with-polycystic-ovary-syndrome
#17
Daimin Wei, Yuhua Shi, Jing Li, Ze Wang, Lin Zhang, Yun Sun, Hong Zhou, Yuping Xu, Chunxiang Wu, Ling Liu, Qiongfang Wu, Lili Zhuang, Yanzhi Du, Weiping Li, Heping Zhang, Richard S Legro, Zi-Jiang Chen
STUDY QUESTION: Do oral contraceptives (OCs) and progestins impact live birth rate of IVF when used for cycle scheduling in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: OCs used for scheduling IVF cycle were associated with lowered rates of pregnancy and live birth after fresh embryo transfer, whereas progestins used for this purpose yield higher rates of pregnancy and live birth than OCs. WHAT IS KNOWN ALREADY: Due to oligo-menorrhea in PCOS, OCs and progestin are extensively used to schedule the start of an IVF cycle in women with PCOS...
December 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27995514/the-need-for-scientific-software-engineering-in-the-pharmaceutical-industry
#18
Brock Luty, Peter W Rose
Scientific software engineering is a distinct discipline from both computational chemistry project support and research informatics. A scientific software engineer not only has a deep understanding of the science of drug discovery but also the desire, skills and time to apply good software engineering practices. A good team of scientific software engineers can create a software foundation that is maintainable, validated and robust. If done correctly, this foundation enable the organization to investigate new and novel computational ideas with a very high level of efficiency...
December 19, 2016: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/27983803/peroxidase-like-activity-of-ethylene-diamine-tetraacetic-acid-and-its-application-for-ultrasensitive-detection-of-tumor-biomarkers-and-circular-tumor-cells
#19
Haowen Huang, Lanfang Liu, Lingyang Zhang, Qian Zhao, Yuan Zhou, Shishan Yuan, Zilong Tang, Xuanyong Liu
Ethylene diamine tetraacetic acid (EDTA) is such a powerful chelating agent that it may form stable complexes with most metal ions, which has wide applications in industry, agriculture, environment, and pharmaceutical technology. Recently, EDTA was found to enhance the photocatalytic property of some materials. Inspired by this fact of EDTA in the photocatalytic role, we further investigated the photocatalytic property of EDTA and found much the same as that of natural horseradish peroxidase (HRP). This significant discovery of peroxidase-like property may extend the applications of conventional EDTA in life science...
December 16, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27982751/an-expert-s-opinion-on-what-lies-ahead-in-the-field-of-alternative-drug-delivery
#20
Tarun Goswami
Tarun Goswami speaks to Hannah Makin, Commissioning Editor: Tarun Goswami obtained his BS (Pharmacy) in 2003 from Delhi University (India) and his PhD in Pharmaceutical Sciences in 2008 from the University of the Pacific (CA, USA). He currently works at Amneal Pharmaceuticals as a Formulation Scientist in the Transdermal Drug Delivery Group. Having published multiple abstracts and articles in the area of transdermal and oral mucosal drug delivery, his current interests include the development of drug products that are administered via alternate routes such as through the skin and oral mucosa...
January 2017: Therapeutic Delivery
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