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https://www.readbyqxmd.com/read/28430108/a-network-physiology-approach-to-the-assessment-of-the-link-between-sinoatrial-and-ventricular-cardiac-controls
#1
Alberto Porta, Vlasta Bari, Beatrice De Maria, Mathias Baumert
A network physiology approach to evaluate the strength of the directed interactions among cardiac controls at sinoatrial and ventricular levels and respiration (R) is proposed. The network is composed of three nodes (i.e. sinoatrial and ventricular cardiac controls and R) and their activity is exemplified by the variability of heart period (HP), the variability of the duration of the electrical activity of the heart approximated as the temporal distance between Q-wave onset and T-wave end or apex (i.e. QTe or QTa) and thoracic movements respectively...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28428553/the-yeast-osmostress-response-is-carbon-source-dependent
#2
Roja Babazadeh, Petri-Jaan Lahtvee, Caroline B Adiels, Mattias Goksör, Jens B Nielsen, Stefan Hohmann
Adaptation to altered osmotic conditions is a fundamental property of living cells and has been studied in detail in the yeast Saccharomyces cerevisiae. Yeast cells accumulate glycerol as compatible solute, controlled at different levels by the High Osmolarity Glycerol (HOG) response pathway. Up to now, essentially all osmostress studies in yeast have been performed with glucose as carbon and energy source, which is metabolised by glycolysis with glycerol as a by-product. Here we investigated the response of yeast to osmotic stress when yeast is respiring ethanol as carbon and energy source...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428250/functional-roles-of-globin-proteins-in-hypoxia-tolerant-ectothermic-vertebrates
#3
Angela Fago
Globins are heme-containing proteins ubiquitously expressed in vertebrates, where they serve a broad range of biological functions, directly or indirectly related to the tight control of oxygen levels and its toxic products in vivo. Perhaps the most investigated of all proteins, hemoglobin and myoglobin are primarily involved in oxygen transport and storage, but also in facilitating arterial vasodilation, suppressing mitochondrial respiration and preventing tissue oxidative damage via accessory redox enzymatic activities during hypoxia...
April 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28428045/sco2-deficient-mice-develop-increased-adiposity-and-insulin-resistance
#4
Shauna Hill, Sathyaseelan S Deepa, Kavithalakshmi Sataranatarajan, Pavithra Premkumar, Daniel Pulliam, Yuhong Liu, Vanessa Y Soto, Kathleen E Fischer, Holly Van Remmen
Cytochrome c oxidase (COX) is an essential transmembrane protein complex (Complex IV) in the mitochondrial respiratory electron chain. Mutations in genes responsible for the assembly of COX are associated with Leigh syndrome, cardiomyopathy, spinal muscular atrophy and other fatal metabolic disorders in humans. Previous studies have shown that mice lacking the COX assembly protein Surf1 (Surf1(-/-) mice) paradoxically show a number of beneficial metabolic phenotypes including increased insulin sensitivity, upregulation of mitochondrial biogenesis, induction of stress response pathways and increased lifespan...
April 17, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28427545/corrigendum-to-efficacy-and-safety-comparison-fluticasone-furoate-and-fluticasone-propionate-after-step-down-from-fluticasone-furoate-vilanterol-in-japanese-patients-with-well-controlled-asthma-a-randomized-trial-respir-med-120-november-2016-78-86
#5
https://www.readbyqxmd.com/read/28425475/insecticidal-activity-of-garlic-essential-oil-and-their-constituents-against-the-mealworm-beetle-tenebrio-molitor-linnaeus-coleoptera-tenebrionidae
#6
Angelica Plata-Rueda, Luis Carlos Martínez, Marcelo Henrique Dos Santos, Flávio Lemes Fernandes, Carlos Frederico Wilcken, Marcus Alvarenga Soares, José Eduardo Serrão, José Cola Zanuncio
This study evaluated the insecticidal activity of garlic, Allium sativum Linnaeus (Amaryllidaceae) essential oil and their principal constituents on Tenebrio molitor. Garlic essential oil, diallyl disulfide, and diallyl sulfide oil were used to compare the lethal and repellent effects on larvae, pupae and adults of T. molitor. Six concentrations of garlic essential oil and their principal constituents were topically applied onto larvae, pupae and adults of this insect. Repellent effect and respiration rate of each constituent was evaluated...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424945/date-palm-waste-biochars-alter-a-soil-respiration-microbial-biomass-carbon-and-heavy-metal-mobility-in-contaminated-mined-soil
#7
Mohammad I Al-Wabel, Adel Rabie A Usman, Abdullah S Al-Farraj, Yong Sik Ok, Adel Abduljabbar, Abdulelah I Al-Faraj, Abdelazeem S Sallam
A 30-day incubation experiment was conducted using a heavy metal-contaminated mined soil amended with date palm feedstock (FS) and its derivative biochars (BCs) at three pyrolysis temperatures of 300 (BC-300), 500 (BC-500), and 700 °C (BC-700) with different application rates (0.0, 5, 15, and 30 g kg(-1)) to investigate their short-term effects on soil respiration (CO2-C efflux), microbial biomass carbon (MBC), soil organic carbon (SOC), mobile fraction of heavy metals (Cd, Cu, Pb, Zn, Mn, and Fe), pH, and electrical conductivity (EC)...
April 19, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28421326/nutrient-enrichment-in-water-more-than-in-leaves-affects-aquatic-microbial-litter-processing
#8
Cristiane Biasi, Manuel A S Graça, Sandro Santos, Verónica Ferreira
Nutrient enrichment of soils and water will intensify in the future and has the potential to alter fundamental ecosystem processes, such as litter decomposition. We tested the direct (via water nutrient enrichment) and indirect (via changes in leaf chemistry) effects of nutrient enrichment on microbial activity and decomposability of Quercus robur L. (oak) leaves in laboratory microcosms simulating streams. Senescent leaves of oak trees grown without and with fertilization were incubated under ambient and elevated water nutrient [nitrogen (N) and phosphorus (P)] concentrations for 60 days...
April 18, 2017: Oecologia
https://www.readbyqxmd.com/read/28419371/sleep-a-window-into-autonomic-control-in-children-born-preterm-and-growth-restricted
#9
Stephanie R Yiallourou, Euan M Wallace, Christie Whatley, Alexsandria Odoi, Samantha Hollis, Aidan J Weichard, Jayan Shivanandhan Muthusamy, Suraj Varma, James Cameron, Om Narayan, Rosemary Sc Horne
Study Objectives: Preterm birth and fetal growth restriction (FGR) are both associated with risk of hypertension in adulthood. Mechanisms leading to this pathology are unclear. In children aged 5-12 years, who were born preterm and FGR, we used sleep as a tool to assess autonomic control with assessment of cardiovascular structure and function. Methods: 18 children born preterm and FGR, 15 born preterm with appropriate birth weights (AGA) and 20 AGA term-born children were studied...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28416465/15-years-of-monitoring-occupational-exposure-to-respirable-dust-and-quartz-within-the-european-industrial-minerals-sector
#10
Hicham Zilaout, Jelle Vlaanderen, Remko Houba, Hans Kromhout
INTRODUCTION: In 2000, a prospective Dust Monitoring Program (DMP) was started in which measurements of worker's exposure to respirable dust and quartz are collected in member companies from the European Industrial Minerals Association (IMA-Europe). After 15 years, the resulting IMA-DMP database allows a detailed overview of exposure levels of respirable dust and quartz over time within this industrial sector. Our aim is to describe the IMA-DMP and the current state of the corresponding database which due to continuation of the IMA-DMP is still growing...
March 27, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28414427/enhancing-extracellular-electron-transfer-of-shewanella-oneidensis-mr-1-through-coupling-improved-flavin-synthesis-and-metal-reducing-conduit-for-pollutant-degradation
#11
Di Min, Lei Cheng, Feng Zhang, Xue-Na Huang, Dao-Bo Li, Dong-Feng Liu, Tai-Chu Lau, Yang Mu, Han-Qing Yu
Dissimilatory metal reducing bacteria (DMRB) are capable of extracellular electron transfer (EET) to insoluble metal oxides, which are used as external electron acceptors by DMRB for their anaerobic respiration. The EET process has important contribution to environmental remediation mineral cycling, and bioelectrochemical systems. However, the low EET efficiency remains to be one of the major bottlenecks for its practical applications for pollutant degradation. In this work, Shewanella oneidensis MR-1, a model DMRB, was used to examine the feasibility of enhancing the EET and its biodegradation capacity through genetic engineering...
April 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28413231/development-of-a-roof-bolter-canopy-air-curtain-for-respirable-dust-control
#12
W R Reed, G J Joy, B Kendall, A Bailey, Y Zheng
Testing of the roof bolter canopy air curtain (CAC) designed by the U.S. National Institute for Occupational Safety and Health (NIOSH) has gone through many iterations, demonstrating successful dust control performance under controlled laboratory conditions. J.H. Fletcher & Co., an original equipment manufacturer of mining equipment, further developed the concept by incorporating it into the design of its roof bolting machines. In the present work, laboratory testing was conducted, showing dust control efficiencies ranging from 17...
January 2017: Mining Engineering
https://www.readbyqxmd.com/read/28413169/respiratory-effects-of-simultaneous-exposure-to-respirable-crystalline-silica-dust-formaldehyde-and-triethylamine-of-a-group-of-foundry-workers
#13
Fatemeh Zarei, Mansour Rezazadeh Azari, Sousan Salehpour, Soheila Khodakarim, Leila Omidi, Elahe Tavakol
BACKGROUND: Foundry workers are occupationally exposed to hazardous substances such as silica dusts and toxic gases. The aim of this study was to examine the effects of simultaneous exposure to complex mixtures of silica dust, formaldehyde, and triethylamine on lung function parameters. STUDY DESIGN: A cross-sectional study. METHODS: This study was conducted on 55 male workers of core making unit of a foundry plant (the case group) and 55 workers in a food industry were enrolled as a control group in 2015...
March 4, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/28409224/occupational-exposure-to-respirable-crystalline-silica-and-chronic-non-malignant-renal-disease-systematic-review-and-meta-analysis
#14
REVIEW
Matthias Möhner, Anne Pohrt, Johannes Gellissen
BACKGROUND: While occupational exposure to respirable silica is known to lead to lung disease, most notably silicosis, its association with chronic kidney disease is unclear. OBJECTIVES: This review explores the association between occupational exposure to respirable silica and chronic non-malignant renal disease such as glomerulonephritis. The evidence has been collected and compiled. Possible sources of bias are thoroughly discussed. METHODS: Cohort studies with silica exposure and case-control studies of renal disease were searched in PubMed until January 2015...
April 13, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28408635/cardiac-autonomic-control-and-complexity-during-sleep-are-preserved-after-chronic-sleep-restriction-in-healthy-subjects
#15
Eleonora Tobaldini, Naima Covassin, Andrew Calvin, Prachi Singh, Jan Bukartyk, Shiang Wang, Nicola Montano, Virend K Somers
Acute sleep deprivation (SD) alters cardiovascular autonomic control (CAC) and is associated with an increased risk of cardiovascular disorders. However, the effects of partial SD on CAC are unclear. Thus, we aimed to investigate the effects of partial SD on CAC during sleep. We randomized seventeen healthy subjects to a restriction group (RES, n = 8, subjects slept two-thirds of normal sleep time based on individual habitual sleep duration for 8 days and 8 nights) or a Control group (CON, n = 9, subjects were allowed to sleep their usual sleep time)...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28408349/early-effects-of-prolonged-cardiac-arrest-and-ischemic-postconditioning-during-cardiopulmonary-resuscitation-on-cardiac-and-brain-mitochondrial-function-in-pigs
#16
Timothy R Matsuura, Jason A Bartos, Adamantios Tsangaris, Kadambari Chandra Shekar, Matthew D Olson, Matthias L Riess, Martin Bienengraeber, Tom P Aufderheide, Robert W Neumar, Jennifer N Rees, Scott H McKnite, Anna E Dikalova, Sergey I Dikalov, Hunter F Douglas, Demetris Yannopoulos
Background Out-of-hospital cardiac arrest (CA) is a prevalent medical crisis resulting in severe injury to the heart and brain and an overall survival of less than 10 percent. Mitochondrial dysfunction is predicted to be a key determinant of poor outcomes following prolonged CA. However, the onset and severity of mitochondrial dysfunction during CA and cardiopulmonary resuscitation (CPR) is not fully understood. Ischemic postconditioning (IPC), controlled pauses during the initiation of CPR, has been shown to improve cardiac function and neurologically favorable outcomes after fifteen minutes of CA...
April 10, 2017: Resuscitation
https://www.readbyqxmd.com/read/28407690/the-suppressing-effects-of-btg3-expression-on-aggressive-behaviors-and-phenotypes-of-colorectal-cancer-an-in-vitro-and-vivo-study
#17
Hua-Chuan Zheng, Hao-Yu He, Ji-Cheng Wu, Jing Li, Shuang Zhao, Gui-Feng Zhao, Hua-Mao Jiang, Xue-Wen Yu, Zhi-Jie Li
Here, we found that down-regulated expression of BTG3 might be positively correlated with colorectal carcinogenesis and its overexpression suppressed proliferation, glycolysis, mitochondrial respiration, cell cycle progression, migration, and invasion, and induced apoptosis, senescence and differentiation in SW480 and SW620 cells. After treated with cisplatin, MG132, paclitaxel and SAHA, BTG3 transfectants exhibited lower viability and higher apoptosis than the control in both time- and dose-dependent manners...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407586/physiological-and-biochemical-impacts-induced-by-mercury-pollution-and-seawater-acidification-in-hediste-diversicolor
#18
Rosa Freitas, Lucia de Marchi, Anthony Moreira, João L T Pestana, Frederick J Wrona, Etelvina Figueira, Amadeu M V M Soares
The present study evaluated the impacts of predicted seawater acidification and Hg pollution, when stressors were acting alone and in combination, on the polychaete Hediste diversicolor. Polychaetes were exposed during 28days to low pH (7.5), Hg (5μg/L) and pH7.5+Hg, and physiological alterations (respiration rate), biochemical markers related to metabolic potential (glycogen and protein content, electron transport system activity) and oxidative status (activity of antioxidant and biotransformation enzymes, lipid peroxidation) were evaluated...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28406926/high-resolution-respirometry-of-fine-needle-muscle-biopsies-in-pre-manifest-huntington-s-disease-expansion-mutation-carriers-shows-normal-mitochondrial-respiratory-function
#19
Eva Buck, Martina Zügel, Uwe Schumann, Tamara Merz, Anja M Gumpp, Anke Witting, Jürgen M Steinacker, G Bernhard Landwehrmeyer, Patrick Weydt, Enrico Calzia, Katrin S Lindenberg
Alterations in mitochondrial respiration are an important hallmark of Huntington's disease (HD), one of the most common monogenetic causes of neurodegeneration. The ubiquitous expression of the disease causing mutant huntingtin gene raises the prospect that mitochondrial respiratory deficits can be detected in skeletal muscle. While this tissue is readily accessible in humans, transgenic animal models offer the opportunity to cross-validate findings and allow for comparisons across organs, including the brain...
2017: PloS One
https://www.readbyqxmd.com/read/28406467/lead-exposure-assessment-among-pregnant-women-newborns-and-children-case-study-from-karachi-pakistan
#20
Zafar Fatmi, Ambreen Sahito, Akihiko Ikegami, Atsuko Mizuno, Xiaoyi Cui, Nathan Mise, Mai Takagi, Yayoi Kobayashi, Fujio Kayama
Lead (Pb) in petrol has been banned in developed countries. Despite the control of Pb in petrol since 2001, high levels were reported in the blood of pregnant women and children in Pakistan. However, the identification of sources of Pb has been elusive due to its pervasiveness. In this study, we assessed the lead intake of pregnant women and one- to three-year-old children from food, water, house dust, respirable dust, and soil. In addition, we completed the fingerprinting of the Pb isotopic ratios (LIR) of petrol and secondary sources (food, house-dust, respirable dust, soil, surma (eye cosmetics)) of exposure within the blood of pregnant women, newborns, and children...
April 13, 2017: International Journal of Environmental Research and Public Health
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