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https://www.readbyqxmd.com/read/28813928/difficulty-adaptation-in-a-competitive-arm-rehabilitation-game-using-real-time-control-of-arm-electromyogram-and-respiration
#1
A Darzi, M Gorsic, D Novak
Rehabilitation robots are often combined with serious games that motivate patients and keep them exercising at high intensities. A promising type of game are competitive rehabilitation games, but few difficulty adaptation algorithms have been presented for them. This paper thus presents the adaptation of difficulty in a competitive arm rehabilitation game based on two physiological signals: respiration and electromyography of the posterior deltoid. It consists of three smaller studies: an open-loop respiration study, a closed-loop respiration study (where a controller attempts to maintain respiration rate at preset levels), and a closed-loop electromyogram study (where a controller attempts to keep the electromyogram at preset levels)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813504/effect-of-co2-induced-seawater-acidification-on-growth-photosynthesis-and-inorganic-carbon-acquisition-of-the-harmful-bloom-forming-marine-microalga-karenia-mikimotoi
#2
Shunxin Hu, Bin Zhou, You Wang, Ying Wang, Xinxin Zhang, Yan Zhao, Xinyu Zhao, Xuexi Tang
Karenia mikimotoi is a widespread, toxic and non-calcifying dinoflagellate, which can release and produce ichthyotoxins and hemolytic toxins affecting the food web within the area of its bloom. Shifts in the physiological characteristics of K. mikimotoi due to CO2-induced seawater acidification could alter the occurrence, severity and impacts of harmful algal blooms (HABs). Here, we investigated the effects of elevated pCO2 on the physiology of K. mikimotoi. Using semi-continuous cultures under controlled laboratory conditions, growth, photosynthesis and inorganic carbon acquisition were determined over 4-6 week incubations at ambient (390ppmv) and elevated pCO2 levels (1000 ppmv and 2000 ppmv)...
2017: PloS One
https://www.readbyqxmd.com/read/28811488/deregulation-of-zpr1-causes-respiratory-failure-in-spinal-muscular-atrophy
#3
Naresh K Genabai, Annapoorna Kannan, Saif Ahmad, Xiaoting Jiang, Kanchan Bhatia, Laxman Gangwani
Spinal muscular atrophy (SMA) is caused by the low levels of survival motor neuron (SMN) protein and is characterized by motor neuron degeneration and muscle atrophy. Respiratory failure causes death in SMA but the underlying molecular mechanism is unknown. The zinc finger protein ZPR1 interacts with SMN. ZPR1 is down regulated in SMA patients. We report that ZPR1 functions downstream of SMN to regulate HoxA5 levels in phrenic motor neurons that control respiration. Spatiotemporal inactivation of Zpr1 gene in motor neurons down-regulates HoxA5 and causes defects in the function of phrenic motor neurons that results in respiratory failure and perinatal lethality in mice...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810688/exhaled-breath-condensate-a-novel-matrix-for-biological-monitoring-to-assess-occupational-exposure-to-respirable-crystalline-silica
#4
Elizabeth Leese, James F Staff, Vikki A Carolan, Jackie Morton
Biological monitoring (BM) is a useful way of determining overall exposures to chemical substances; however, in the case of respirable crystalline silica (RCS), this has not been analytically feasible in conventional biological matrices. The aim of this study was to investigate the utility of exhaled breath condensate (EBC) as a potential biological matrix in which to determine exposure to RCS. A small pilot study was undertaken collecting EBC from six quarry workers and six occupationally unexposed persons; the samples were analysed using both single particle inductively coupled plasma mass spectrometry (spICP-MS) and transmission electron microscopy (TEM)...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28807815/bcl-xl-knockout-attenuates-mitochondrial-respiration-and-causes-oxidative-stress-that-is-compensated-by-pentose-phosphate-pathway-activity
#5
Annika Pfeiffer, Julia Schneider, Diones Bueno, Amalia Dolga, Timo-Daniel Voss, Jan Lewerenz, Verena Wüllner, Axel Methner
Bcl-xL is an anti-apoptotic protein that localizes to the outer mitochondrial membrane and influences mitochondrial bioenergetics by controlling Ca(2+) influx into mitochondria. Here, we analyzed the effect of mitochondrial Bcl-xL on mitochondrial shape and function in knockout (KO), wildtype and rescued mouse embryonic fibroblast cell lines. Mitochondria of KO cells were more fragmented, exhibited a reduced ATP concentration, and reduced oxidative phosphorylation (OXPHOS) suggesting an increased importance of ATP generation by other means...
August 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28805919/cows-exposed-to-heat-stress-during-fetal-life-exhibit-improved-thermal-tolerance
#6
B M S Ahmed, U Younas, T O Asar, S Dikmen, P J Hansen, G E Dahl
Maternal heat stress during late gestation affects calf function during postnatal life. The objective of the present study was to evaluate whether calves that experience heat stress in utero have altered thermoregulatory responses to acute heat stress later in life. Specifically, the hypothesis was that heat stress in utero would improve the response to acute heat stress at maturity. Females were born to dams exposed to heat stress or cooled during late gestation preceding their birth. All animals were raised postnatally under identical management...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805897/effects-of-grass-silage-quality-and-level-of-feed-intake-on-enteric-methane-production-in-lactating-dairy-cows
#7
D Warner, A Bannink, B Hatew, H van Laar, J Dijkstra
The objective of this study was to determine the effect of level of feed intake and quality of ryegrass silage as well as their interaction on enteric methane (CH) emission from dairy cows. In a randomized block design, 56 lactating dairy cows received a diet of grass silage, corn silage, and a compound feed meal (70:10:20 on DM basis). Treatments consisted of 4 grass silage qualities prepared from grass harvested from leafy through late heading stage, and offered to dairy cows at 96 ± 2.4 (mean ± SEM) days in milk (namely, high intake) and 217 ± 2...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28803850/association-of-exposure-to-manganese-and-iron-with-striatal-and-thalamic-gaba-and-other-neurometabolites-neuroimaging-results-from-the-weldox-ii-study
#8
Swaantje Casjens, Urike Dydak, Shalmali Dharmadhikari, Anne Lotz, Martin Lehnert, Clara Quetscher, Christoph Stewig, Benjamin Glaubitz, Tobias Schmidt-Wilcke, David Edmondson, Chien-Lin Yeh, Tobias Weiss, Christoph van Thriel, Lennard Herrmann, Siegfried Muhlack, Dirk Woitalla, Michael Aschner, Thomas Brüning, Beate Pesch
OBJECTIVE: Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the striatum and thalamus of 154 men. MATERIAL AND METHODS: GABA-edited and short echo-time MRS at 3T was used to assess brain levels of GABA, glutamate, total creatine (tCr) and other neurometabolites...
August 10, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28803751/insulin-prevents-aberrant-mitochondrial-phenotype-in-sensory-neurons-of-type-1-diabetic-rats
#9
Mohamad-Reza Aghanoori, Darrell R Smith, Subir Roy Chowdhury, Mohammad Golam Sabbir, Nigel A Calcutt, Paul Fernyhough
Diabetic neuropathy affects approximately 50% of diabetic patients. Down-regulation of mitochondrial gene expression and function has been reported in both human tissues and in dorsal root ganglia (DRG) from animal models of type 1 and type 2 diabetes. We hypothesized that loss of direct insulin signaling in diabetes contributes to loss of mitochondrial function in DRG neurons and to development of neuropathy. Sensory neurons obtained from age-matched adult control or streptozotocin (STZ)-induced type 1 diabetic rats were cultured with or without insulin before determining mitochondrial respiration and expression of mitochondrial respiratory chain and insulin signaling-linked proteins...
August 10, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28799710/the-efficacy-of-medical-masks-and-respirators-against-respiratory-infection-in-health-workers
#10
Chandini Raina MacIntyre, Abrar Ahmad Chughtai, Bayzidur Rahman, Yang Peng, Yi Zhang, Holly Seale, Xiaoli Wang, Quanyi Wang
OBJECTIVE: We aim to examine the efficacy of medical masks and respirators in protecting against respiratory infections using pooled data from two homogenous randomised control clinical trials (RCTs). METHODS: The data collected on 3591 subjects in two similar RCTs conducted in Beijing China, which examined the same infection outcomes, were pooled. Four interventions were compared; a) continuous N95 respirator use, b) targeted N95 respirator use, c) medical mask use and, d) control arm...
August 11, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28798236/the-unintended-mitochondrial-uncoupling-effects-of-the-fda-approved-anti-helminth-drug-nitazoxanide-mitigates-experimental-parkinsonism-in-mice
#11
Niharika Amireddy, Srinivas N Puttapaka, Ravali L Vinnakota, Halley G Ravuri, Swaroop Thonda, Shasi V Kalivendi
Mitochondria plays a primary role in the pathophysiology of Parkinson's disease (PD) and small molecules that counteract the initial stages of disease may offer therapeutic benefit. In this regard, we have examined whether the off-target effects of the FDA approved anti-helminth drug, nitazoxanide (NTZ) on mitochondrial respiration could possess any therapeutic potential for PD. Results indicate that MPP(+) induced loss in oxygen consumption rate (OCR) and ATP production by mitochondria were ameliorated by NTZ in real-time by virtue of its mild-uncoupling effect...
August 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28797887/grassland-productivity-and-carbon-sequestration-in-mongolian-grasslands-the-underlying-mechanisms-and-nomadic-implications
#12
Changliang Shao, Jiquan Chen, Housen Chu, Raffaele Lafortezza, Gang Dong, Michael Abraha, Ochirbat Batkhishig, Ranjeet John, Zutao Ouyang, Yaoqi Zhang, Jiaguo Qi
BACKGROUND: Quantifying carbon (C) dioxide exchanges between ecosystems and the atmosphere and the underlying mechanism of biophysical regulations under similar environmental conditions is critical for an accurate understanding of C budgets and ecosystem functions. METHODS: For the first time, a cluster of four eddy covariance towers were set up to answer how C fluxes shift among four dominant ecosystems in Mongolia - meadow steppe (MDW), typical steppe (TPL), dry typical steppe (DRT) and shrubland (SHB) during two growing seasons (2014 and 2015)...
August 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/28797310/maternal-intake-of-trans-unsaturated-or-interesterified-fatty-acids-during-pregnancy-and-lactation-modifies-mitochondrial-bioenergetics-in-the-liver-of-adult-offspring-in-mice
#13
Patricia C de Velasco, Gustavo Chicaybam, Dionizio M Ramos-Filho, Raísa M A R Dos Santos, Caroline Mairink, Fátima L C Sardinha, Tatiana El-Bacha, Antonio Galina, Maria das Graças Tavares-do-Carmo
The quality of dietary lipids in the maternal diet can programme the offspring to diseases in later life. We investigated whether the maternal intake of palm oil or interesterified fat, substitutes for trans-unsaturated fatty acids (FA), induces metabolic changes in the adult offspring. During pregnancy and lactation, C57BL/6 female mice received normolipidic diets containing partially hydrogenated vegetable fat rich in trans-unsaturated fatty acids (TG), palm oil (PG), interesterified fat (IG) or soyabean oil (CG)...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28793281/photosynthetic-limitation-and-mechanisms-of-photoprotection-under-drought-and-recovery-of-calotropis-procera-an-evergreen-c3-from-arid-regions
#14
Rebeca Rivas, Gabriella Frosi, Diego G Ramos, Silvia Pereira, Ana M Benko-Iseppon, Mauro G Santos
Calotropis procera is a C3 plant native from arid environmental zones. It is an evergreen, shrubby, non-woody plant with intense photosynthetic metabolism during the dry season. We measured photosynthetic parameters and leaf biochemical traits, such as gas exchange, photochemical parameters, A/Ci analysis, organic solutes, and antioxidant enzymes under controlled conditions in potted plants during drought stress, and following recovery conditions to obtain a better insight in the drought stress responses of C...
July 31, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28790926/moderate-exercise-allows-for-shorter-recovery-time-in-critical-limb-ischemia
#15
Anne Lejay, Gilles Laverny, Stéphanie Paradis, Anna-Isabel Schlagowski, Anne-Laure Charles, François Singh, Joffrey Zoll, Fabien Thaveau, Evelyne Lonsdorfer, Stéphane Dufour, Fabrice Favret, Valérie Wolff, Daniel Metzger, Nabil Chakfe, Bernard Geny
Whether and how moderate exercise might allow for accelerated limb recovery in chronic critical limb ischemia (CLI) remains to be determined. Chronic CLI was surgically induced in mice, and the effect of moderate exercise (training five times per week over a 3-week period) was investigated. Tissue damages and functional scores were assessed on the 4th, 6th, 10th, 20th, and 30th day after surgery. Mice were sacrificed 48 h after the last exercise session in order to assess muscle structure, mitochondrial respiration, calcium retention capacity, oxidative stress and transcript levels of genes encoding proteins controlling mitochondrial functions (PGC1α, PGC1β, NRF1) and anti-oxidant defenses markers (SOD1, SOD2, catalase)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28790283/-postoperative-atelectasis-and-pneumonia-after-general-thoracic-surgery
#16
Yasushi Hoshikawa, Daisuke Tochii
Atelectasis and pneumonia are common postoperative complications occurred in patients undergoing general thoracic surgery. Strategies to reduce the risk of postoperative pulmonary complications including these 2 disorders consist of smoking cessation, optimization of underlying chronic obstructive pulmonary disease( COPD), adequate pain control, intensive oral care, and so on. Preoperative treatments for patients with COPD are the same as those for COPD patients being not about to have surgery, which mainly consist of long-acting bronchodilators and pulmonary rehabilitation...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28790203/the-in-feed-antibiotic-carbadox-induces-phage-gene-transcription-in-the-swine-gut-microbiome
#17
Timothy A Johnson, Torey Looft, Andrew J Severin, Darrell O Bayles, Daniel J Nasko, K Eric Wommack, Adina Howe, Heather K Allen
Carbadox is a quinoxaline-di-N-oxide antibiotic fed to over 40% of young pigs in the United States that has been shown to induce phage DNA transduction in vitro; however, the effects of carbadox on swine microbiome functions are poorly understood. We investigated the in vivo longitudinal effects of carbadox on swine gut microbial gene expression (fecal metatranscriptome) and phage population dynamics (fecal dsDNA viromes). Microbial metagenome, transcriptome, and virome sequences were annotated for taxonomic inference and gene function by using FIGfam (isofunctional homolog sequences) and SEED subsystems databases...
August 8, 2017: MBio
https://www.readbyqxmd.com/read/28781901/enkephalins-endogenous-analgesics-with-an-emerging-role-in-stress-resilience
#18
REVIEW
Mathilde S Henry, Louis Gendron, Marie-Eve Tremblay, Guy Drolet
Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for Alzheimer's disease. Stress resilience is a positive outcome that is associated with preserved cognition and healthy aging. Resilience presents psychological and biological characteristics intrinsic to an individual conferring protection against the development of psychopathologies in the face of adversity...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28781720/mitochondrial-respiration-in-human-colorectal-and-breast-cancer-clinical-material-is-regulated-differently
#19
Andre Koit, Igor Shevchuk, Lyudmila Ounpuu, Aleksandr Klepinin, Vladimir Chekulayev, Natalja Timohhina, Kersti Tepp, Marju Puurand, Laura Truu, Karoliina Heck, Vahur Valvere, Rita Guzun, Tuuli Kaambre
We conducted quantitative cellular respiration analysis on samples taken from human breast cancer (HBC) and human colorectal cancer (HCC) patients. Respiratory capacity is not lost as a result of tumor formation and even though, functionally, complex I in HCC was found to be suppressed, it was not evident on the protein level. Additionally, metabolic control analysis was used to quantify the role of components of mitochondrial interactosome. The main rate-controlling steps in HBC are complex IV and adenine nucleotide transporter, but in HCC, complexes I and III...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28781256/-metabolomic-blood-test-purpose-implementation-and-interpretation-of-data
#20
REVIEW
P G Lokhov, A V Lisitsa, A I Archakov
The human body is an open system that receives a variety of xenobiotics in the course of dietary route or respiration and in the form of the drugs. As a lump sum scores of toxic and potentially toxic substances are detected in a human body that significantly affect health and human lifespan. There are also thousands of diseases, dozens of which latently occur in the body of each person. Traditional diagnosis is not able to screen all the variety of xenobiotics and potential human diseases. For this purpose metabolomic blood test is available which is of non-targeted (review) nature...
May 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
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