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https://www.readbyqxmd.com/read/28526903/compartmental-tongue-resection-with-submental-island-flap-reconstruction-for-large-carcinoma-of-the-oral-tongue
#1
Sameh Roshdy, Mohamed Elbadrawy, Ashraf Khater, Tamer Fady, Hend A El-Hadaad, Nazem Shams, Hany M Elbarbary
BACKGROUND: Tongue resection is a surgical challenge because of its adverse effects on language articulation, swallowing, respiration, the eventual quality of life, and poor prognosis of advanced disease. To date, the currently accepted standard treatment has been based on excision of the primary lesion with a 1.5-2-cm circumferential macroscopic margin. Compartmental tongue surgery (CTS) is a surgical technique that removes an anatomo-functional compartment containing the primary tumor...
May 19, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28526373/coffee-consumption-in-aged-mice-increases-energy-production-and-decreases-hepatic-mtor-levels
#2
Keita Takahashi, Shuichi Yanai, Kentaro Shimokado, Akihito Ishigami
OBJECTIVE: Coffee, one of the world's most consumed beverages, has many benefits. Some studies have reported the effects of coffee on aging. The aim of this study was to investigate the locomotor activity, energy metabolism, and lipid metabolism of aged (20-mo-old) mice given coffee. METHODS: Aged C57 BL/6 NCr mice were divided into three groups: controls that were not given coffee (n = 9), a group that received 0.1% caffeinated coffee (n = 9), and a group that received 0...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28525966/gene-expression-of-vibrio-parahaemolyticus-growing-in-laboratory-isolation-conditions-compared-to-those-common-in-its-natural-ocean-environment
#3
Katherine García, Cristian Yáñez, Nicolás Plaza, Francisca Peña, Pedro Sepúlveda, Diliana Pérez-Reytor, Romilio T Espejo
BACKGROUND: Vibrio parahaemolyticus is an autochthonous marine bacterial species comprising strains able to grow in broth containing bile salts at 37 °C, a condition seldom found in the ocean. However, this condition is used for isolation in the laboratory because it is considered a necessary property for pathogenesis. In this context, revealing how gene expression enables V. parahaemolyticus to adapt to this particular condition -common to almost all V. parahaemolyticus isolates- will improve our understanding of the biology of this important pathogen...
May 19, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28525343/changes-of-hematological-and-biochemical-parameters-and-levels-of-pepsinogen-histamine-and-prostaglandins-in-dairy-cows-affected-with-left-displacement-of-the-abomasum
#4
O Al-Rawashdeh, Z Bani Ismail, A Talafha, A Al-Momani
The aims of this study were to determine the serum levels of pepsinogen, histamine, and prostaglandins F2α and E2 in lactating dairy cows affected with left displacement of the abomasum (LDA). In addition, the hematological and serum biochemical parameters were also determined in cows affected with LDA. A total of 52 adult lactating Holstein-Friesian cows affected with LDA and 30 normal cows (control) were used. In LDA cows, the average age, BCS and body weight were 4.9 ± 1.2 years, 2.5 ± 0.75, and 525 ± 150kg respectively...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28522765/exercise-training-in-tg%C3%AE-q-44-mice-during-the-progression-of-chronic-heart-failure-cardiac-vs-peripheral-soleus-muscle-impairments-to-oxidative-metabolism
#5
Bruno Grassi, Joanna Majerczak, Eleonora Bardi, Alessia Buso, Marina Comelli, Stefan Chlopicki, Magdalena Guzik, Irene Mavelli, Zenon Nieckarz, Desy Salvadego, Urszula Tyrankiewicz, Tomasz Skorka, Roberto Bottinelli, Jerzy A Zoladz, Maria Antonietta Pellegrino
Cardiac function, skeletal (soleus) muscle oxidative metabolism and the effects of exercise training were evaluated in a transgenic murine model (Tgαq*44) of chronic heart failure (CHF) during the critical period between the occurrence of an impairment of cardiac function and the stage at which overt cardiac failure ensues (i.e. from 10 to 12 months of age). Forty-eight Tgαq*44 mice and 43 wild-type (WT) FVB controls were randomly assigned to control groups and to groups undergoing 2 months of intense exercise training (spontaneous running on a instrumented wheel)...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28522085/blood-pressure-after-modified-uvulopalatopharyngoplasty-results-from-the-skup-3-randomized-controlled-trial
#6
Johan Fehrm, Danielle Friberg, Johan Bring, Nanna Browaldh
OBJECTIVE: Obstructive sleep apnea (OSA) is a risk factor for hypertension. The SKUP(3) study showed that modified uvulopalatopharyngoplasty (UPPP) significantly improved nocturnal respiration, sleepiness, and quality of life. The aim of this study was to evaluate the impact of surgery on blood pressure in patients with OSA. METHODS: We used a single-center randomized controlled trial to compare modified UPPP with controls at baseline and after six months. The controls received delayed surgery with an additional six-month follow-up...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28519901/inhibition-of-soil-microbial-activity-by-nitrogen-based-energetic-materials
#7
Roman G Kuperman, Morgan L Minyard, Ronald T Checkai, Geoffrey I Sunahara, Sylvie Rocheleau, Sabine G Dodard, Louise Paquet, Jalal Hawari
We investigated individual toxicities of nitrogen-based energetic materials (EMs) 2,4-dinitrotoluene (2,4-DNT); 2-amino-4,6-dinitrotoluene (2-ADNT); 4-amino-2,6-dinitrotoluene (4-ADNT); and nitroglycerin (NG) on microbial activity in Sassafras sandy loam (SSL) soil, which has physicochemical characteristics that support "very high" qualitative relative bioavailability for organic chemicals. Batches of SSL soil for basal respiration (BR) and substrate-induced respiration (SIR) assays were separately amended with individual EMs or acetone carrier control...
May 18, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28515881/effect-of-bursaphelenchus-xylophilus-infection-on-leaf-photosynthetic-characteristics-and-resource-use-efficiency-of-pinus-massoniana
#8
Ruihe Gao, Zhuang Wang, Juan Shi, Youqing Luo
Pine wilt disease (PWD) is considered as the most destructive forest-invasive alien species in China. We measured gas exchange parameters and foliar carbon isotope ratios (δ(13)C) of different infection phases of Masson pine in order to investigate the effect of Bursaphelenchus xylophilus infection on photosynthetic responses and resource-use efficiency. The results showed that net photosynthetic rate (Pn), transpiration rate (T), stomatal conductance (gs), and internal CO 2 concentrations (Ci) decreased in the infested trees at photosynthetic photon flux density (PPFD) levels from 0 to 2,000 μmol m(-2) s(-1) compared with controls...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28514978/jugular-infused-methionine-lysine-and-branched-chain-amino-acids-does-not-improve-milk-production-in-holstein-cows-experiencing-heat-stress
#9
K R Kassube, J D Kaufman, K G Pohler, J W McFadden, A G Ríus
Poor utilization of amino acids contributes to losses of milk protein yield in dairy cows exposed to heat stress (HS). Our objective was to test the effect of essential amino acids on milk production in lactating dairy cows exposed to short-term HS conditions. To achieve this objective, 12 multiparous, lactating Holstein cows were assigned to two environments (thermoneutral (THN) or HS) from days 1 to 14 in a split-plot type cross-over design. All cows received 0 g/day of essential amino acids from days 1 to 7 (negative control (NC)) followed by an intravenous infusion of l-methionine (12 g/day), l-lysine (21 g/day), l-leucine (35 g/day), l-isoleucine (15 g/day) and l-valine (15 g/day, methionine, lysine and branched-chain amino acids (ML+BCAA)) from days 8 to 14...
May 18, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28507314/metabolic-imaging-of-energy-metabolism-in-traumatic-brain-injury-using-hyperpolarized-1-13-c-pyruvate
#10
Stephen J DeVience, Xin Lu, Julie Proctor, Parisa Rangghran, Elias R Melhem, Rao Gullapalli, Gary M Fiskum, Dirk Mayer
Traumatic brain injury (TBI) is known to cause perturbations in the energy metabolism of the brain, but current tests of metabolic activity are only indirect markers of energy use or are highly invasive. Here we show that hyperpolarized (13)C magnetic resonance spectroscopic imaging (MRSI) can be used as a direct, non-invasive method for studying the effects of TBI on energy metabolism. Measurements were performed on rats with moderate TBI induced by controlled cortical impact on one cerebral hemisphere. Following injection of hyperpolarized [1-(13)C]pyruvate, the resulting (13)C-bicarbonate signal was found to be 24 ± 6% lower in the injured hemisphere compared with the non-injured hemisphere, while the hyperpolarized bicarbonate-to-lactate ratio was 33 ± 8% lower in the injured hemisphere...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28507235/assessing-the-strength-of-cardiac-and-sympathetic-baroreflex-controls-via-transfer-entropy-during-orthostatic-challenge
#11
Alberto Porta, Andrea Marchi, Vlasta Bari, Beatrice De Maria, Murray Esler, Elisabeth Lambert, Mathias Baumert
The study assesses the strength of the causal relation along baroreflex (BR) in humans during an incremental postural challenge soliciting the BR. Both cardiac BR (cBR) and sympathetic BR (sBR) were characterized via BR sequence approaches from spontaneous fluctuations of heart period (HP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and muscle sympathetic nerve activity (MSNA). A model-based transfer entropy method was applied to quantify the strength of the coupling from SAP to HP and from DAP to MSNA...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28506182/elemental-properties-of-copper-slag-and-measured-airborne-exposures-at-a-copper-slag-processing-facility
#12
Christopher Mugford, Jenna L Gibbs, Randy Boylstein
In 1974, the National Institute for Occupational Safety and Health recommended a ban on the use of abrasives containing >1% silica, giving rise to abrasive substitutes like copper slag. We present results from a National Institute for Occupational Safety and Health industrial hygiene survey at a copper slag processing facility that consisted of the collection of bulk samples for metals and silica; and full-shift area and personal air samples for dust, metals, and respirable silica. Carcinogens, suspect carcinogens, and other toxic elements were detected in all bulk samples, and area and personal air samples...
May 16, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28505389/nitrogen-and-phosphorus-availabilities-interact-to-modulate-leaf-trait-scaling-relationships-across-six-plant-functional-types-in-a-controlled-environment-study
#13
Kristine Y Crous, Odhran S O'Sullivan, Joana Zaragoza-Castells, Keith J Bloomfield, A Clarissa A Negrini, Patrick Meir, Matthew H Turnbull, Kevin L Griffin, Owen K Atkin
Nitrogen (N) and phosphorus (P) have key roles in leaf metabolism, resulting in a strong coupling of chemical composition traits to metabolic rates in field-based studies. However, in such studies, it is difficult to disentangle the effects of nutrient supply per se on trait-trait relationships. Our study assessed how high and low N (5 mM and 0.4 mM, respectively) and P (1 mM and 2 μM, respectively) supply in 37 species from six plant functional types (PTFs) affected photosynthesis (A) and respiration (R) (in darkness and light) in a controlled environment...
May 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/28504343/gas-diffusion-in-the-cns
#14
REVIEW
Beatriz Rodriguez-Grande, Jan-Pieter Konsman
Gases have been long known to have essential physiological functions in the CNS such as respiration or regulation of vascular tone. Since gases have been classically considered to freely diffuse, research in gas biology has so far focused on mechanisms of gas synthesis and gas reactivity, rather than gas diffusion and transport. However, the discovery of gas pores during the last two decades and the characterization of diverse diffusion patterns through different membranes has raised the possibility that modulation of gas diffusion is also a physiologically relevant parameter...
May 15, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28504300/effect-of-protection-against-hot-climate-on-growth-performance-physiological-response-and-endocrine-profile-of-growing-lambs-under-semi-arid-tropical-environment
#15
Kalyan De, Davendra Kumar, Anoop Kumar Singh, Kamal Kumar, Artabandhu Sahoo, Syed Mohammed Khursheed Naqvi
In the hot semi-arid tropical region, extreme summer is a major constraint in sheep production. The growth performance of growing lambs is impaired during the summer. Therefore, the present study was conducted to assess the effect of protection against hot climate on growth performance, physiological response, and endocrine profile of growing lambs under semi-arid tropical environment. All the data in the experiment were presented as mean ± SE. Thirty Malpura lambs with the age of 122.7 ± 6.05 days and body weight of 19...
May 13, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28500267/impaired-mitochondrial-transcription-termination-disrupts-the-stromal-redox-poise-in-chlamydomonas
#16
Andreas Uhmeyer, Matteo Ballottari, Michela Cecchin, Lutz Wobbe
In photosynthetic eukaryotes, the metabolite exchange between chloroplast and mitochondria ensures efficient photosynthesis under saturating light conditions. The C. reinhardtii mutant stm6 is devoid of the mitochondrial transcription termination factor (mTERF) MOC1 and aberrantly expresses the mitochondrial genome, resulting in enhanced photosynthetic hydrogen production and diminished light tolerance. We analyzed the modulation of mitochondrial and chlororespiration during the acclimation of stm6 and the MOC1-complemented strain to excess light...
May 12, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28496106/neuregulin-1-improves-complex-2-mediated-mitochondrial-respiration-in-skeletal-muscle-of-healthy-and-diabetic-mice
#17
Gaël Ennequin, Frederic Capel, Kevin Caillaud, Vivien Chavanelle, Monique Etienne, Allison Teixeira, Xinyan Li, Nathalie Boisseau, Pascal Sirvent
It has been reported that neuregulin1 (NRG1) improves glucose tolerance in healthy and diabetic rodents. In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity. To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatment with NRG1 in db/db diabetic mice and C57BL/6JRJ healthy controls. NRG1 treatment improved complex 2-mediated mitochondrial respiration in the gastrocnemius of both control and diabetic mice and increased mitochondrial complex 2 subunit content by 2-fold...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495619/the-respire-trials-two-phase-iii-randomized-multicentre-placebo-controlled-trials-of-ciprofloxacin-dry-powder-for-inhalation-ciprofloxacin-dpi-in-non-cystic-fibrosis-bronchiectasis
#18
Timothy Aksamit, Tiemo-Joerg Bandel, Margarita Criollo, Anthony De Soyza, J Stuart Elborn, Elisabeth Operschall, Eva Polverino, Katrin Roth, Kevin L Winthrop, Robert Wilson
The primary goals of long-term disease management in non-cystic fibrosis bronchiectasis (NCFB) are to reduce the number of exacerbations, and improve quality of life. However, currently no therapies are licensed for this. Ciprofloxacin Dry Powder for Inhalation (Ciprofloxacin DPI) has potential to be the first long-term intermittent therapy approved to reduce exacerbations in NCFB patients. The RESPIRE programme consists of two international phase III prospective, parallel-group, randomized, double-blinded, multicentre, placebo-controlled trials of the same design...
May 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28490511/impact-of-breakfast-skipping-compared-with-dinner-skipping-on-regulation-of-energy-balance-and-metabolic-risk
#19
Alessa Nas, Nora Mirza, Franziska Hägele, Julia Kahlhöfer, Judith Keller, Russell Rising, Thomas A Kufer, Anja Bosy-Westphal
Background: Meal skipping has become an increasing trend of the modern lifestyle that may lead to obesity and type 2 diabetes.Objective: We investigated whether the timing of meal skipping impacts these risks by affecting circadian regulation of energy balance, glucose metabolism, and postprandial inflammatory responses.Design: In a randomized controlled crossover trial, 17 participants [body mass index (in kg/m(2)): 23.7 ± 4.6] underwent 3 isocaloric 24-h interventions (55%, 30%, and 15% carbohydrate, fat, and protein, respectively): a breakfast skipping day (BSD) and a dinner skipping day (DSD) separated by a conventional 3-meal-structure day (control)...
May 10, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28482850/mutant-tdp-43-does-not-impair-mitochondrial-bioenergetics-in-vitro-and-in-vivo
#20
Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M Ravits, Anatoly Starkov, Giovanni Manfredi
BACKGROUND: Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused mostly on superoxide dismutase 1 (SOD1) mutants, and showed that mutant human SOD1 impairs mitochondrial oxidative phosphorylation, calcium homeostasis, and dynamics. However, recent reports have indicated that alterations in transactivation response element DNA-binding protein 43 (TDP-43) can also lead to defects of mitochondrial morphology and dynamics...
May 8, 2017: Molecular Neurodegeneration
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