Sarah A Brendle, Jingwei J Li, Vonn Walter, Todd D Schell, Michael Kozak, Karla K Balogh, Song Lu, Neil D Christensen, Yusheng Zhu, Karam El-Bayoumy, Jiafen Hu
Human papillomavirus (HPV)-induced oropharyngeal cancer now exceeds HPV-induced cervical cancer, with a noticeable sex bias. Although it is well established that women have a more proficient immune system, it remains unclear whether immune control of oral papillomavirus infections differs between sexes. In the current study, we use genetically modified mice to target CCR2 and Stat1 pathways, with the aim of investigating the role of both innate and adaptive immune responses in clearing oral papillomavirus, using our established papillomavirus (MmuPV1) infection model...
December 14, 2023: Pathogens