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Tongue stimulation

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https://www.readbyqxmd.com/read/28614457/immediate-effects-of-tongue-trills-associated-with-transcutaneous-electrical-nerve-stimulation-tens
#1
Eliana Maria Gradim Fabron, Andressa Schweitzer Petrini, Vanessa de Moraes Cardoso, João Carlos Torgal Batista, Suely Mayumi Motonaga, Viviane Cristina de Castro Marino
Purpose: To investigate vocal quality variability after applying tongue trills associated with transcutaneous electrical nerve stimulation (TENS) on the larynx of women with normal laryngeal function. Additionally, to verify the effect of this technique over time on voice quality. Methods: Participants were 40 women (average 23.4 years) without vocal complaints. The procedure involved tongue trills with or without TENS for 3 minutes, rest and repeating the technique for another 2 minutes...
June 8, 2017: CoDAS
https://www.readbyqxmd.com/read/28612077/neuronavigated-high-frequency-repetitive-transcranial-magnetic-stimulation-for-chronic-post-stroke-dysphagia-a-randomized-controlled-study
#2
Ivy K Y Cheng, Karen M K Chan, Chun-Sing Wong, Leonard S W Li, Karen M Y Chiu, Raymond T F Cheung, Edwin M L Yiu
OBJECTIVE: There are potential benefits of repetitive transcranial magnetic stimulation (rTMS) in improving swallowing functions after stroke; however, few studies have been performed in the chronic stroke population. This study aims to distil the key effects of rTMS on swallowing functions and swallowing-related quality of life. METHODS: Twenty-two participants with chronic post-stroke dysphagia were randomly assigned into active or sham rTMS groups. Seven participants withdrew from the study, thus data from 15 participants (mean age 64...
May 30, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28607750/noninvasive-tongue-stimulation-combined-with-intensive-cognitive-and-physical-rehabilitation-induces-neuroplastic-changes-in-patients-with-multiple-sclerosis-a-multimodal-neuroimaging-study
#3
Gabriel Leonard, Yves Lapierre, Jen-Kai Chen, Rima Wardini, Joelle Crane, Alain Ptito
BACKGROUND: Multiple sclerosis (MS) patients have central nervous system (CNS) lesions that may impede cognitive and sensorimotor function. Few rehabilitative therapies are available. OBJECTIVES: The objective of this paper is to study effects of noninvasive tongue stimulation using the Portable Neuromodulation Stimulator (PoNS™) combined with intensive cognitive and physical rehabilitation on working memory, gait, balance and concomitant changes in the brain...
January 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28556188/effect-of-transcranial-direct-current-stimulation-on-neuroplasticity-in-corticomotor-pathways-of-the-tongue-muscles
#4
Mohit Kothari, Peter W Stubbs, Krystian Figlewski, Asger R Pedersen, Jim Jensen, Lene Baad-Hansen, Peter Svensson, Jørgen F Nielsen
To investigate effects of transcranial direct current stimulation (tDCS) on neuroplasticity in corticomotor pathways related to tongue muscles evoked by a training task using the Tongue Drive System (TDS). Using a cross-over design, 13 healthy participants completed two sessions of tDCS while performing 30 min of TDS training. Sessions were spaced at least 2 weeks apart and participants randomly received anodal and sham tDCS stimulation in the first session and the other condition in the second session. Single and paired pulse transcranial magnetic stimulation was used to elicit motor evoked potentials (MEPs) of the tongue at three time-points; before, immediately after and 30 min after training...
May 28, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28526071/retinoid-acid-induced-microrna-31-5p-suppresses-myogenic-proliferation-and-differentiation-by-targeting-camkii%C3%AE
#5
Bo Liu, Chao Liu, Wei Cong, Nan Li, Nan Zhou, Yi Tang, Chao Wei, Han Bai, Ying Zhang, Jing Xiao
BACKGROUND: We previously reported that Wnt5a/CaMKIIδ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity induced by excess retinoic acid (RA). Our latest study found that the expression of miR-31-5p, which was predicted to target the 3'UTR of CamkIIδ, was raised in the RA-treated embryonic tongue. Thus, we hypothesized that the excess RA regulated Wnt5a/CaMKIIδ pathway through miR-31-5p in embryonic tongue. METHODS: C2C12 myoblast line was employed as an in vitro model to examine the suppression of miR-31-5p on CamkIIδ expression, through which RA impaired the myoblast proliferation and differentiation in embryonic tongue...
May 11, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28521453/nicotine-may-promote-tongue-squamous-cell-carcinoma-progression-by-activating-the-wnt-%C3%AE-catenin-and-wnt-pcp-signaling-pathways
#6
Chengze Wang, Xin Xu, Hairu Jin, Gangli Liu
To investigate the effects and the possible underlying mechanisms of nicotine stimulation on tongue squamous cell carcinoma (TSCC) progression, a TSCC cell line Cal27 and 34 samples of paraffin-embedded TSCC were examined. Immunofluorescence, western blot analysis, and TOP/FOP flash, CCK-8, wound healing and Transwell invasion assays were used to evaluate Cal27 in response to nicotine stimulation. We also investigated expression levels of related proteins of Wnt/β-catenin and Wnt/PCP pathways in paraffin-embedded TSCC samples with or without a history of smoking by immunohistochemistry...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28517962/inhibition-of-the-continuum-of-radiation-induced-normal-tissue-injury-by-a-redox-active-mn-porphyrin
#7
Samuel R Birer, Chen-Ting Lee, Kingshuk Roy Choudhury, Kenneth H Young, Ivan Spasojevic, Ines Batinic-Haberle, James D Crapo, Mark W Dewhirst, Kathleen A Ashcraft
Normal tissue damage after head and neck radiotherapy involves a continuum of pathologic events to the mucosa, tongue and salivary glands. We examined the radioprotective effects of MnBuOE, a redox-active manganese porphyrin, at three stages of normal tissue damage: immediate (leukocyte endothelial cell [L/E] interactions), early (mucositis) and late (xerostomia and fibrosis) after treatment. In this study, mice received 0 or 9 Gy irradiation to the oral cavity and salivary glands ± MnBuOE treatment. Changes in leukocyte-endothelial cell interactions were measured 24 h postirradiation...
May 18, 2017: Radiation Research
https://www.readbyqxmd.com/read/28484380/perceived-intensity-and-discrimination-ability-for-lingual-electrotactile-stimulation-depends-on-location-and-orientation-of-electrodes
#8
Joel Moritz, Philip Turk, John D Williams, Leslie M Stone-Roy
Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often involves the use of bioengineered devices that electrically stimulate somatosensory fibers. Interestingly, the tongue is an ideal location for electrotactile stimulation due to its dense innervation, moisture, and protected environment. Success with transmitting visual and vestibular information through the tongue indicates promise for future applications...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28481721/s-oralis-activates-the-efg1-filamentation-pathway-in-c-albicans-to-promote-cross-kingdom-interactions-and-mucosal-biofilms
#9
Hongbin Xu, Takanori Sobue, Martinna Bertolini, Angela Thompson, Margaret Vickerman, Clarissa J Nobile, Anna Dongari-Bagtzoglou
Candida albicans and Streptococcus oralis are ubiquitous oral commensal organisms. Under host-permissive conditions these organisms can form hypervirulent mucosal biofilms. C. albicans biofilm formation is controlled by 6 master transcriptional regulators: Bcr1, Brg1, Efg1, Tec1, Ndt80, and Rob1. The objective of this work was to test whether any of these regulators play a role in cross-kingdom interactions between C. albicans and S. oralis in oral mucosal biofilms, and identify downstream target gene(s) that promote these interactions...
May 8, 2017: Virulence
https://www.readbyqxmd.com/read/28454080/relevance-of-ccl3-ccr5-axis-in-oral-carcinogenesis
#10
Janine Mayra da Silva, Tálita Pollyanna Moreira Dos Santos, Lays Martin Sobral, Celso Martins Queiroz-Junior, Milene Alvarenga Rachid, Amanda E I Proudfoot, Gustavo Pompermaier Garlet, Aline Carvalho Batista, Mauro Martins Teixeira, Andréia Machado Leopoldino, Remo Castro Russo, Tarcília Aparecida Silva
The chemokine CCL3 is a chemotactic cytokine crucial for inflammatory cell recruitment in homeostatic and pathological conditions. CCL3 might stimulate cancer progression by promoting leukocyte accumulation, angiogenesis and tumour growth. The expression of CCL3 and its receptors CCR1 and CCR5 was demonstrated in oral squamous cell carcinoma (OSCC), but their role was not defined. Here, the functions of CCL3 were assessed using a model of chemically induced tongue carcinogenesis with 4-nitroquinoline-1-oxide (4NQO)...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412164/diagnosis-and-management-of-oropharyngeal-dysphagia-among-older-persons-state-of-the-art
#11
REVIEW
Omar Ortega, Alberto Martín, Pere Clavé
Oropharyngeal dysphagia (OD) is a condition recognized by the World Health Organization and defined as the difficulty or inability to move a bolus safely and effectively from the oral cavity to the esophagus, and can include aspirations, choking, and residue. OD is pandemic among different phenotypes of older people, affecting between 27% and 91% of the population 70 years or older. Although OD can be diagnosed by well-defined clinical methods and complementary explorations, in the clinical setting OD is seldom systematically screened and treated, and awareness among the medical/geriatric community is scarce...
April 12, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28400725/cortical-mechanisms-of-tongue-sensorimotor-functions-in-humans-a-review-of-the-magnetoencephalography-approach
#12
REVIEW
Hitoshi Maezawa
The tongue plays important roles in a variety of critical human oral functions, including speech production, swallowing, mastication and respiration. These sophisticated tongue movements are in part finely regulated by cortical entrainment. Many studies have examined sensorimotor processing in the limbs using magnetoencephalography (MEG), which has high spatiotemporal resolution. Such studies have employed multiple methods of analysis, including somatosensory evoked fields (SEFs), movement-related cortical fields (MRCFs), event-related desynchronization/synchronization (ERD/ERS) associated with somatosensory stimulation or movement and cortico-muscular coherence (CMC) during sustained movement...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28399391/cd163-positive-macrophages-within-the-tumor-stroma-are-associated-with-lymphangiogenesis-and-lymph-node-metastasis-in-oral-squamous-cell-carcinoma
#13
Yuko Yamagata, Hirofumi Tomioka, Kei Sakamoto, Kiyoshi Sato, Hiroyuki Harada, Tohru Ikeda, Kou Kayamori
PURPOSE: Increasing evidence shows that tumor stromal components, particularly tumor-associated macrophages (TAMs), play an important role in the tumor progression of various solid malignant tumor types. However, their roles in oral squamous cell carcinoma (OSCC) have not been fully elucidated. MATERIALS AND METHODS: Seventy human tongue OSCC samples were analyzed in the present study. Immunohistochemistry was used to investigate the correlations between the densities of CD68-, CD163-, and CD204-positive TAMs and clinicopathologic parameters...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28382034/neutrophil-extracellular-traps-of-cynoglossus-semilaevis-production-characteristics-and-antibacterial-effect
#14
Ming-Li Zhao, Heng Chi, Li Sun
Neutrophil extracellular traps (NETs) are structures released by neutrophils as a cellular immune defense against microbial invasion. The process of NETs generation, netosis (NETosis), can take place via either a suicidal mechanism, during which the NETs-releasing cells became dead, or a "live" mechanism, during which the NETs-releasing cells remain vital. NETosis has been studied intensively in mammals in recent years, but very little is known about the NETosis in fish. In this study, we examined NETosis in tongue sole (Cynoglossus semilaevis), a species of teleost with important economic values...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28378061/tongue-surgeries-for-pediatric-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#15
REVIEW
Macario Camacho, Michael W Noller, Soroush Zaghi, Lauren K Reckley, Camilo Fernandez-Salvador, Erika Ho, Brandyn Dunn, Dylan Chan
OBJECTIVES: To evaluate the international literature for studies reporting outcomes for obstructive sleep apnea (OSA) in children undergoing isolated tongue surgeries. METHODS: Two authors searched from inception through November 14, 2016 in four databases including PubMed/MEDLINE. RESULTS: 351 studies were screened. Eleven studies (116 children) met criteria. Most children were syndromic and had craniofacial disorders, co-morbidities, or other serious medical issues...
April 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28361201/swallowing-function-after-continuous-neuromuscular-electrical-stimulation-of-the-submandibular-region-evaluated-by-high-resolution-manometry
#16
Michael Jungheim, Christoph Schubert, Simone Miller, Martin Ptok
Although neuromuscular electrical stimulation (NMES) is increasingly used in dysphagia therapy, patient responses to NMES are inconsistent and conflicting results have been reported. This, together with a lack of information about the effects of NEMS on the swallowing process, has led to an ongoing debate about its impact on swallowing function. In order to address this, we set out to (i) collect baseline information on the physiological effects of NMES on the complex pharyngeal phase of swallowing and (ii) to compare two different stimulation protocols...
March 30, 2017: Dysphagia
https://www.readbyqxmd.com/read/28356653/effects-of-electrical-stimulation-combined-with-dysphagia-therapy-in-elderly-individual-with-oropharyngeal-dysphagia-a-case-study
#17
Doo-Ho Lee, Ji-Su Park, Seung-Woong Lee, Jong-Bae Choi
[Purpose] The purpose of the present study was to investigate the effects of dysphagia therapy in an old man with difficulty swallowing in the oral and pharyngeal phases. [Subjects and Methods] The subject was a 72-year-old man with no history of neurological disorders. He was admitted to local hospital because of the complaint of swallowing difficulty. The interventions performed were electrical stimulation and conventional dysphagia therapy. We assessed the tongue and lip muscle strengths. Swallowing function was evaluated by using the videofluoroscopic dysphagia and penetration-aspiration scales...
March 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28276979/the-influence-of-external-stimulation-in-missing-knowledge-retrieval
#18
Rémi Radel, Marion Fournier
We investigated the effects of sensory reduction on the retrieval of information during tip-of-the-tongue (TOT) experiences. As conscious access results from severe competition in which external stimuli often have priority, we hypothesised that reducing external stimulation would allow individuals greater access to weakly activated inner knowledge. In Study 1, when participants experienced a TOT while answering a general knowledge question, they were given additional time to find the solution in a restricted (eyes closed + silence) or a non-restricted (eyes open + ambient noise) external stimulation environment...
February 16, 2017: Memory
https://www.readbyqxmd.com/read/28239466/nivolumab-induced-myxedema-crisis
#19
Uqba Khan, Humaira Rizvi, Dahlia Sano, Jane Chiu, Tarik Hadid
BACKGROUND: Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody that is approved by Food and Drug Administration for treatment of metastatic non-small cell lung cancer, metastatic melanoma, relapsed Hodgkin lymphoma and advanced renal cell cancer. We report a rare case of myxedema crisis induced by nivolumab in a patient with metastatic squamous cell carcinoma of lung. CASE PRESENTATION: Fifty three-year old woman with metastatic squamous cell carcinoma currently on treatment with nivolumab presented with diffuse facial and tongue swelling, slurred speech, depressed mentation, fatigue and weakness...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28231591/predictive-success-factors-in-selective-upper-airway-stimulation
#20
Clemens Heiser, Benedikt Hofauer
Obstructive sleep apnea is one of the most common diseases in Western industrialized countries. A variety of conservative and surgical treatment options are available for its treatment. In recent years, selective upper airway stimulation (sUAS) has been shown to be effective and safe. Different biomarkers have been investigated as predictive clinical success factors in a number of clinical trials. Age does not matter in sUAS, as compared to its predictive role in other therapies. Weight seems to play a limited role, depending on drug-induced sleep endoscopy to rule out a complete concentric collapse with an increased body mass index...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
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