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Tongue stimulation

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https://www.readbyqxmd.com/read/28109977/c-fos-expression-in-the-parabrachial-nucleus-following-intraoral-bitter-stimulation-in-the-rat-with-dietary-induced-zinc-deficiency
#1
Akiyo Kawano, Shiho Honma, Chizuko Inui-Yamamoto, Akira Ito, Hitoshi Niwa, Satoshi Wakisaka
Zinc deficiency causes various symptoms including taste disorders. In the present study, changes in expression of c-Fos immunoreactivity in neurons of the parabrachial nucleus (PBN), one of the relay nuclei for transmission of gustatory information, after bitter stimulation to the dorsal surface of the tongue were examined in zinc-deficient rats. Experimental zinc-deficient animals were created by feeding a low-zinc diet for 4 weeks, and showed the following symptoms of zinc deficiency: low body weight, low serum zinc content and behavioral changes to avoid bitter stimulation...
January 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28106324/verbal-instructions-influence-pain-thresholds-assessment-a-study-using-manual-and-electronic-mechanical-stimulators
#2
K Suzuki, L Baad-Hansen, P Svensson
BACKGROUND: Quantitative sensory testing (QST) relies on psychophysical techniques and instructions to test subjects. This study examined the effect of different verbal instructions for mechanical pain thresholds (MPTs) using two different stimulation techniques; weighted pinprick stimulators and an electronic von Frey device (EvF). The test-retest reliability and within session variability in the MPTs for each verbal instruction were compared in addition. METHODS: Sixteen healthy volunteers participated...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28105667/palatoglossus-coupling-in-selective-upper-airway-stimulation
#3
Clemens Heiser, Günther Edenharter, Murat Bas, Markus Wirth, Benedikt Hofauer
OBJECTIVES/HYPOTHESIS: Selective upper airway stimulation (sUAS) of the hypoglossal nerve is a useful therapy to treat patients with obstructive sleep apnea. Is it known that multiple obstructions can be solved by this stimulation technique, even at the retropalatal region. The aim of this study was to verify the palatoglossus coupling at the soft palate during stimulation. STUDY DESIGN: Single-center, prospective clinical trail. METHODS: Twenty patients who received an sUAS implant from April 2015 to April 2016 were included...
January 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28074885/first-objective-evaluation-of-taste-sensitivity-to-6-n-propylthiouracil-prop-a-paradigm-gustatory-stimulus-in-humans
#4
Giorgia Sollai, Melania Melis, Danilo Pani, Piero Cosseddu, Ilenia Usai, Roberto Crnjar, Annalisa Bonfiglio, Iole Tomassini Barbarossa
Practical and reliable methods for the objective measure of taste function are critically important for studying eating behavior and taste function impairment. Here, we present direct measures of human gustatory response to a prototypical bitter compound, 6-n-propyltiouracil (PROP), obtained by electrophysiological recordings from the tongue of subjects who were classified for taster status and genotyped for the specific receptor gene (TAS2R38), and in which taste papilla density was determined. PROP stimulation evoked negative slow potentials that represent the summated depolarization of taste cells...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28050345/functional-mri-vs-navigated-tms-to-optimize-m1-seed-volume-delineation-for-dti-tractography-a-prospective-study-in-patients-with-brain-tumours-adjacent-to-the-corticospinal-tract
#5
Carolin Weiss Lucas, Irada Tursunova, Volker Neuschmelting, Charlotte Nettekoven, Ana-Maria Oros-Peusquens, Gabriele Stoffels, Andrea Maria Faymonville, Shah N Jon, Karl Josef Langen, Hannah Lockau, Roland Goldbrunner, Christian Grefkes
BACKGROUND: DTI-based tractography is an increasingly important tool for planning brain surgery in patients suffering from brain tumours. However, there is an ongoing debate which tracking approaches yield the most valid results. Especially the use of functional localizer data such as navigated transcranial magnetic stimulation (nTMS) or functional magnetic resonance imaging (fMRI) seem to improve fibre tracking data in conditions where anatomical landmarks are less informative due to tumour-induced distortions of the gyral anatomy...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28017205/meige-s-syndrome-history-epidemiology-clinical-features-pathogenesis-and-treatment
#6
REVIEW
Sanjay Pandey, Soumya Sharma
'Meige's syndrome' is a type of cranial dystonia characterized by blepharospasm and oromandibular dystonia and can be associated with complex movement of lower facial muscles, mouth, jaw, tongue, pharyngeal and cervical muscles. Frequently, blepharospasm is the earliest clinical manifestation, which spreads over a period of time to involve other cranial and extra-cranial muscles. Common characteristics of this syndrome are well known, but their variety is wide. Different eponyms such as "Breughel syndrome", "Wood syndrome", "Blepharospasm plus", "Segmental cranial dystonia" and "Segmental cranio-cervical dystonia" have been used to describe this entity with numerous anatomical variations...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28008939/csmap34-a-teleost-map-with-dual-role-a-promoter-of-masp-assisted-complement-activation-and-a-regulator-of-immune-cell-activity
#7
Mo-Fei Li, Jun Li, Li Sun
In teleost fish, the immune functions of mannan-binding lectin (MBL) associated protein (MAP) and MBL associated serine protease (MASP) are scarcely investigated. In the present study, we examined the biological properties both MAP (CsMAP34) and MASP (CsMASP1) molecules from tongue sole (Cynoglossus semilaevis). We found that CsMAP34 and CsMASP1 expressions occurred in nine different tissues and were upregulated by bacterial challenge. CsMAP34 protein was detected in blood, especially during bacterial infection...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974743/high-order-synchronization-of-hair-cell-bundles
#8
Michael Levy, Adrian Molzon, Jae-Hyun Lee, Ji-Wook Kim, Jinwoo Cheon, Dolores Bozovic
Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A nanomagnetic technique is used to stimulate the bundles without an imposed mechanical load. The evoked response shows regimes of high-order mode-locking. Exploring a broad range of stimulus frequencies and intensities, we observe regions of high-order synchronization, analogous to Arnold Tongues in dynamical systems literature...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27926482/hexokinase-2-enhances-the-metastatic-potential-of-tongue-squamous-cell-carcinoma-via-the-sod2-h2o2-pathway
#9
Wei Wang, Zhonghua Liu, Luodan Zhao, Jingjing Sun, Qianting He, Wangxiang Yan, Zhiyuan Lu, Anxun Wang
The glycolytic enzyme hexokinase (HK2), which is aberrantly expressed in various types of tumours, is associated with metastasis. However, its role in the progression and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. The results of our study showed that HK2 expression is often deregulated in TSCC patients. Increased HK2 expression was associated with tumour stage, clinical stage, lymph node metastasis, but not pathological grade, and reduced overall survival. Microarray and western blotting analyses revealed increases in HK2 expression in TSCC cells with higher metastatic potential...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27914100/transient-immunological-and-clinical-effectiveness-of-treating-mice-bearing-premalignant-oral-lesions-with-pd-1-antibodies
#10
Corinne A Levingston, M Rita I Young
A carcinogen-induced premalignant oral lesion model that progresses to oral cancer was used to examine the impact of blocking PD-1 on cytokine expression and on progression of lesions to cancer. The results of this study show increased production of IL-2 and the inflammatory cytokines IL-6, IL-17 and TNF-α by spleen cells of lesion-bearing mice that were treated with PD-1 antibody for one week compared to cytokine production by spleen cells of lesion-bearing mice treated with control antibody. Production of IFN-γ increased at 3 weeks of PD-1 antibody treatment, although production of the other Th1 and inflammatory mediators declined...
December 3, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27898891/behavior-and-inflammation-of-the-rumen-and-cecum-in-holstein-bulls-fed-high-concentrate-diets-with-different-concentrate-presentation-forms-with-or-without-straw-supplementation
#11
M Devant, G B Penner, S Marti, B Quintana, F Fábregas, A Bach, A Arís
Twenty-four individually housed Holstein bulls (395 ± 7.3 kg BW and 252 ± 3.1 d age) were exposed to a 2 × 2 factorial design (meal vs. pellets; with vs. without straw) to evaluate the effect of concentrate form and provision of straw in finishing diets on behavior and expression of rumen and cecum epithelium genes related to inflammation and behavior. Concentrate and straw consumption were recorded monthly and behavior (self-grooming, social, oral nonnutritive, tongue rolling, eating, drinking, ruminating, and lying) was recorded every two weeks...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27884757/the-role-of-hearing-ability-and-speech-distortion-in-the-facilitation-of-articulatory-motor-cortex
#12
Helen E Nuttall, Daniel Kennedy-Higgins, Joseph T Devlin, Patti Adank
Excitability of articulatory motor cortex is facilitated when listening to speech in challenging conditions. Beyond this, however, we have little knowledge of what listener-specific and speech-specific factors engage articulatory facilitation during speech perception. For example, it is unknown whether speech motor activity is independent or dependent on the form of distortion in the speech signal. It is also unknown if speech motor facilitation is moderated by hearing ability. We investigated these questions in two experiments...
January 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/27881723/intraspinal-microstimulation-and-diaphragm-activation-following-cervical-spinal-cord-injury
#13
Lynne M Mercier, Elisa J Gonzalez-Rothi, Kristi A Streeter, Savannah S Posgai, Alexander S Poirier, David D Fuller, Paul J Reier, David M Baekey
Intraspinal microstimulation (ISMS), using implanted electrodes, can evoke locomotor movements after spinal cord injury (SCI), but has not been explored in the context of respiratory motor output. An advantage over epidural and direct muscle stimulation is the potential of ISMS to selectively stimulate components of the spinal respiratory network. The present study tested the hypothesis that medullary respiratory activity could be used to trigger mid-cervical ISMS and diaphragm motor unit activation in rats with cervical SCI...
November 23, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27858088/specific-branches-of-hypoglossal-nerve-to-genioglossus-muscle-as-a-potential-target-of-selective-neurostimulation-in-obstructive-sleep-apnea-anatomical-and-morphometric-study
#14
Philippe Delaey, Jérôme Duisit, Catherine Behets, Thierry Duprez, Pierre Gianello, Benoît Lengelé
PURPOSE: To determine the ideal implantation site for selective tongue neurostimulation in obstructive sleep apnea, anatomy of the distal branching of the hypoglossal nerve (HGN) was revisited. METHODS: The HGN distal course and intramuscular distribution to the tongue muscles were studied in 17 embalmed and 5 fresh heads (age 60-98, BMI 20-35). Medial branches supplying selectively the genioglossus (GG) muscle were identified. Then, the distinct bundles entering the oblique (GGo) and horizontal (GGh) parts of the GG were located...
November 17, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27836602/a-biomimetic-bioelectronic-tongue-a-switch-for-on-and-off-response-of-acid-sensations
#15
Wei Zhang, Peihua Chen, Lianqun Zhou, Zhen Qin, Keqiang Gao, Jia Yao, Chuanyu Li, Ping Wang
The perception of sour taste in mammals is important for its basic modality properties and avoiding toxic substances. We explore a biomimetic bioelectronic tongue, which integrate MEA (microelectrode array) and taste receptor cell for acid detection as a switch. However, the acid-sensing mechanism and coding of the taste receptor cells in the periphery is not well understood, with long-standing debate. Therefore, we firstly construct a Hodgkin-Huxley type mathematical model of whole-cell acid-sensing taste receptor cells based on the electrophysiologic patch clamp recordings with different acid sensitive receptor expressing and different acidic stimulations...
October 27, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27829262/-upper-airway-stimulation-in-osa
#16
B Bender
Anatomical basis of obstructive sleep apnea (OSA) is the collapse of the pharynx during sleep. It is considered as a result of complex interactions of structural and neuromuscular factors. Depth of sleep and body position have modulating effects. Although different areas of obstruction were identified, studies show that the sleep-mediated obstruction frequently occurs in the base of tongue area.Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnea syndrome (OSAS) since more than 30 years...
November 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27821280/the-hearing-ear-is-always-found-close-to-the-speaking-tongue-review-of-the-role-of-the-motor-system-in-speech-perception
#17
REVIEW
Jeremy I Skipper, Joseph T Devlin, Daniel R Lametti
Does "the motor system" play "a role" in speech perception? If so, where, how, and when? We conducted a systematic review that addresses these questions using both qualitative and quantitative methods. The qualitative review of behavioural, computational modelling, non-human animal, brain damage/disorder, electrical stimulation/recording, and neuroimaging research suggests that distributed brain regions involved in producing speech play specific, dynamic, and contextually determined roles in speech perception...
January 2017: Brain and Language
https://www.readbyqxmd.com/read/27799705/effect-of-orofacial-myofunctional-exercise-on-the-improvement-of-dysphagia-patients-orofacial-muscle-strength-and-diadochokinetic-rate
#18
Haewon Byeon
[Purpose] Measurement of the diadochokinetic rate can provide useful information on swallowing rehabilitation in the oral phase by elucidating the speed and regularity of movement of muscles related to the lips, tongue, and chin. This study investigated the effect of a three-week period of orofacial myofunctional exercise on the improvement of cheek, tongue, and lip muscle strength and diadochokinetic rate in dysphagia patients. [Subjects and Methods] This study employed a pretest-posttest control group design...
September 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27792802/assessment-of-mechanical-pain-thresholds-in-the-orofacial-region-a-comparison-between-pinprick-stimulators-and-electronic-von-frey-device
#19
Kayo Suzuki, Lene Baad-Hansen, Maria Pigg, Peter Svensson
AIMS: To compare mechanical pain thresholds (MPTs) in the orofacial region assessed with two different approaches: with an electronic von Frey (EvF) device and with custom-made weighted pinprick stimulators. The test-retest reliability, variability of MPTs, and time duration of each test were also compared, as well as the ability of each test to create stimulus-response (S-R) curves. METHODS: A total of 16 healthy volunteers participated. The MPT and S-R curve measurements were done with the two different techniques at three sites: on the skin of the right cheek (face), on the buccal gingival mucosa of the right upper premolar region (gingiva), and on the tip of the tongue (tongue)...
October 2016: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/27765329/effect-of-g-csf-on-oral-mucositis-and-traumatic-ulcers-produced-in-the-tongue-of-rats-undergoing-radiotherapy-clinical-and-histologic-evaluation
#20
Juliana Jasper, Sérgio Roithmann, Renata Stifelman Camilotti, Fernanda Gonçalves Salum, Karen Cherubini, Maria Antonia Zancanaro de Figueiredo
OBJECTIVE: To investigate the effect of granulocyte colony-stimulating factor (G-CSF) on oral mucositis (OM) and on the healing of traumatic ulcers produced in the tongue of rats undergoing radiotherapy (RT). STUDY DESIGN: Twenty-seven Wistar rats were assigned to four groups: (1) RT + traumatic ulcer + filgrastim (G-CSF analog; n = 7); (2) RT + traumatic ulcer + saline (n = 7); (3) no RT + traumatic ulcer + filgrastim (n = 7); and (4) no RT + traumatic ulcer (n = 6)...
November 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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