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Tongue stimulation

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https://www.readbyqxmd.com/read/28822779/molecular-characterization-of-kiss2-and-differential-regulation-of-reproduction-related-genes-by-sex-steroids-in-the-hypothalamus-of-half-smooth-tongue-sole-cynoglossus-semilaevis
#1
Bin Wang, Quan Liu, Xuezhou Liu, Yongjiang Xu, Xuesong Song, Bao Shi
Kisspeptin (Kiss) plays a critical role in mediating gonadal steroid feedback to the gonadotropin-releasing hormone (GnRH) neurons in mammals. However, little information regarding the regulation of kisspeptin gene by sex steroids is available in teleosts. In this study, we examined the direct actions of estradiol (E2) and testosterone (T) on hypothalamic expression of kisspeptin and other key factors involved in reproductive function of half-smooth tongue sole. As a first step, a partial-length cDNA of kiss2 was identified from the brain of tongue sole and kiss2 transcript levels were shown to be widely expressed in various tissues, notably in the ovary...
August 16, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28801293/-effect-of-macrophage-inflammatory-protein-1%C3%AE-on-proliferation-and-apoptosis-of-human-tongue-squamous-cell-carcinoma-cal-27-cells-in-vitro
#2
Bo Jia, Xiao-Ling Qiu, Hong-Xing Chu, Xiang Sun, Jie Pan, Zhi-Ping Wang, Jian-Jiang Zhao
OBJECTIVE: To detect CCR5 protein expression in different human tongue squamous cell carcinoma cells and observe the effect of macrophage inflammatory protein-1β (MIP-1β) on the proliferation and apoptosis of CAL-27 cells. METHODS: Western blotting and immunofluorescence staining were used to detect the expression of the CCR5, the receptor of MIP-1β, in 3 human tongue squamous cell carcinoma cells UM-1, CAL-27, and Tca-8113. CCK-8 assay was used to assess the proliferation of CAL-27 cells stimulated with 10, 20, and 40 ng/mL MIP-1β for 12, 24, or 48 h...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28771697/effects-of-centrally-administered-endocannabinoids-and-opioids-on-orofacial-pain-perception-in-rats
#3
Marek Zubrzycki, Anna Janecka, Andreas Liebold, Mechthild Ziegler, Maria Zubrzycka
BACKGROUND AND PURPOSE: Endocannabinoids and opioids play a vital role in mediating pain-induced analgesia. The specific effects of these compounds within orofacial region are largely unknown. In this study we tried to determine whether the increase of cannabinoid and opioid concentration in cerebrospinal fluid affects impulse transmission between the motor centers localized in the vicinity of the third and fourth cerebral ventricles. EXPERIMENTAL APPROACH: The study objectives were realized on rats using the method allowing to record the amplitude of evoked tongue jerks (ETJ) in response to noxious tooth pulp stimulation...
August 3, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28767651/an-automated-system-for-the-objective-evaluation-of-human-gustatory-sensitivity-using-tongue-biopotential-recordings
#4
Danilo Pani, Ilenia Usai, Piero Cosseddu, Melania Melis, Giorgia Sollai, Roberto Crnjar, Iole Tomassini Barbarossa, Luigi Raffo, Annalisa Bonfiglio
The goal of this work is to develop an automatic system for the evaluation of the gustatory sensitivity of patients using an electrophysiological recording of the response of bud cells to taste stimuli. In particular, the study aims to evaluate the effectiveness and limitations of supervised classifiers in the discrimination between subjects belonging to the three 6-n-propylthiouracil (PROP) taster categories (supertasters, medium tasters, and non-tasters), exploiting features extracted from electrophysiological recordings of the tongue...
2017: PloS One
https://www.readbyqxmd.com/read/28762780/applications-of-prebiotics-in-food-industry-a-review
#5
Vinti Singla, S Chakkaravarthi
Benefits of prebiotics for stimulating a healthy intestinal tract are well known. From suppression of pathogens to proliferation of indigenous bacteria of intestines, prebiotics have it all. Since the research on the scope of prebiotics is expanding, new applications are coming up every day thus upgrading the choices consumer has for a healthy living. Incorporation of prebiotics in a wide range of products that food industry offers on shelf is an innovative way to replace fat and sugars along with enhancing the mouthfeel by providing better tongue lubrication...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28754347/inhibitory-action-of-tongue-sole-lpxrfa-the-piscine-ortholog-of-gonadotropin-inhibitory-hormone-on-the-signaling-pathway-induced-by-tongue-sole-kisspeptin-in-cos-7-cells-transfected-with-their-cognate-receptors
#6
Bin Wang, Guokun Yang, Quan Liu, Jingkai Qin, Yongjiang Xu, Wensheng Li, Xuezhou Liu, Bao Shi
Kisspeptin (Kiss) acts as a positive regulator of reproduction by acting on gonadotropes and gonadotropin-releasing hormone (GnRH) neurons. Despite its functional significance, the intricate web of intracellular signal transduction pathways in response to Kiss is still far from being fully understood in teleosts. Accordingly, we investigated the molecular mechanism of Kiss action and its possible interaction with LPXRFa signaling in this study. In vitro functional analysis revealed that synthetic tongue sole Kiss2 decapeptide increased the cAMP responsive element-dependent luciferase (CRE-luc) activity in COS-7 cells transfected with its cognate receptor, while this stimulatory effect was markedly reduced by two inhibitors of the adenylate cyclase (AC)/protein kinase A (PKA) pathway...
July 25, 2017: Peptides
https://www.readbyqxmd.com/read/28715374/in-vivo-evaluation-of-the-mechanical-and-viscoelastic-properties-of-the-rat-tongue
#7
Emanuele Loro, Stephen H Wang, Richard J Schwab, Tejvir S Khurana
The tongue is a highly innervated and vascularized muscle hydrostat on the floor of the mouth of most vertebrates. Its primary functions include supporting mastication and deglutition, as well as taste-sensing and phonetics. Accordingly, the strength and volume of the tongue can impact the ability of vertebrates to accomplish basic activities such as feeding, communicating, and breathing. Human patients with sleep apnea have enlarged tongues, characterized by reduced muscle tone and increased intramuscular fat that can be visualized and quantified by magnetic resonance imaging (MRI)...
July 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28709287/mode-locking-behavior-of-izhikevich-neurons-under-periodic-external-forcing
#8
AmirAli Farokhniaee, Edward W Large
Many neurons in the auditory system of the brain must encode periodic signals. These neurons under periodic stimulation display rich dynamical states including mode locking and chaotic responses. Periodic stimuli such as sinusoidal waves and amplitude modulated sounds can lead to various forms of n:m mode-locked states, in which a neuron fires n action potentials per m cycles of the stimulus. Here, we study mode-locking in the Izhikevich neurons, a reduced model of the Hodgkin-Huxley neurons. The Izhikevich model is much simpler in terms of the dimension of the coupled nonlinear differential equations compared with other existing models, but excellent for generating the complex spiking patterns observed in real neurons...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28689344/neurological-results-of-the-modified-treatment-of-epilepsy-by-stimulation-of-the-vagus-nerve
#9
Michael Vaiman, Eli Heyman, Gad Lotan
INTRODUCTION: The vagus nerve stimulation (VNS) is used for treatment of drug-resistant epilepsy but laryngeal side effects are common. We tried to improve VNS by modifying the implantation procedure. The aim was to reduce the rate of side effects that have prevented using VNS to its full capacity. METHODS: We operated on 74 pediatric patients for VNS device implantation using a modified surgical protocol incorporating lower neck incision for electrode placement and 36 patients who were operated by standard technique were used for control group...
July 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28653289/histamine-h4-receptor-signalling-in-tongue-cancer-and-its-potential-role-in-oral-carcinogenesis%C3%A2-a-short-report
#10
Abdelhakim Salem, Rabeia Almahmoudi, Dyah Listyarifah, Maria Siponen, Katariina Maaninka, Ahmed Al-Samadi, Tuula Salo, Kari K Eklund
PURPOSE: Recent reports indicate that histamine and its novel, high-affinity histamine H4 receptor (H4R) play a role in carcinogenesis, and thus H4R signalling has become a focus of increasing interest in the pathogenesis of many cancers. The roles of H4R in oral epithelial dysplasia (OED) and oral tongue squamous cell carcinoma (OTSCC) are unknown. The purpose of this study was to assess H4R expression in OTSCC patients and in OTSCC-derived cell lines. METHODS: Biopsies taken from OED, OTSCC and healthy oral mucosa were studied by immunostaining...
June 26, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28643390/oral-disorders-saliva-secretion-and-oral-health-related-quality-of-life-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#11
Shermin Rusthen, Alix Young, Bente B Herlofson, Lara A Aqrawi, Morten Rykke, Lene H Hove, Øyvind Palm, Janicke L Jensen, Preet B Singh
Chemosensory function, burning sensations in the tongue (BST), halitosis, saliva secretion, and oral health-related quality of life (OHRQoL) were investigated in patients with primary Sjögren's syndrome (pSS). In 31 patients with pSS and 33 controls, olfactory and gustatory functions were evaluated. Self-reported complaints of dysgeusia, BST, and halitosis were recorded. Saliva secretion rates were measured and OHRQoL was assessed using the short-form Oral Health Impact Profile (OHIP-14). Patients had significantly lower olfactory (8...
June 23, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28614457/immediate-effects-of-tongue-trills-associated-with-transcutaneous-electrical-nerve-stimulation-tens
#12
COMPARATIVE STUDY
Eliana Maria Gradim Fabron, Andressa Schweitzer Petrini, Vanessa de Moraes Cardoso, João Carlos Torgal Batista, Suely Mayumi Motonaga, Viviane Cristina de Castro Marino
Purpose: To investigate vocal quality variability after applying tongue trills associated with transcutaneous electrical nerve stimulation (TENS) on the larynx of women with normal laryngeal function. Additionally, to verify the effect of this technique over time on voice quality. Methods: Participants were 40 women (average 23.4 years) without vocal complaints. The procedure involved tongue trills with or without TENS for 3 minutes, rest and repeating the technique for another 2 minutes...
June 8, 2017: CoDAS
https://www.readbyqxmd.com/read/28612077/neuronavigated-high-frequency-repetitive-transcranial-magnetic-stimulation-for-chronic-post-stroke-dysphagia-a-randomized-controlled-study
#13
Ivy K Y Cheng, Karen M K Chan, Chun-Sing Wong, Leonard S W Li, Karen M Y Chiu, Raymond T F Cheung, Edwin M L Yiu
OBJECTIVE: There are potential benefits of repetitive transcranial magnetic stimulation (rTMS) in improving swallowing functions after stroke; however, few studies have been performed in the chronic stroke population. This study aims to distil the key effects of rTMS on swallowing functions and swallowing-related quality of life. METHODS: Twenty-two participants with chronic post-stroke dysphagia were randomly assigned into active or sham rTMS groups. Seven participants withdrew from the study, thus data from 15 participants (mean age 64...
May 30, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28607750/noninvasive-tongue-stimulation-combined-with-intensive-cognitive-and-physical-rehabilitation-induces-neuroplastic-changes-in-patients-with-multiple-sclerosis-a-multimodal-neuroimaging-study
#14
Gabriel Leonard, Yves Lapierre, Jen-Kai Chen, Rima Wardini, Joelle Crane, Alain Ptito
BACKGROUND: Multiple sclerosis (MS) patients have central nervous system (CNS) lesions that may impede cognitive and sensorimotor function. Few rehabilitative therapies are available. OBJECTIVES: The objective of this paper is to study effects of noninvasive tongue stimulation using the Portable Neuromodulation Stimulator (PoNS™) combined with intensive cognitive and physical rehabilitation on working memory, gait, balance and concomitant changes in the brain...
January 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28556188/effect-of-transcranial-direct-current-stimulation-on-neuroplasticity-in-corticomotor-pathways-of-the-tongue-muscles
#15
M Kothari, P W Stubbs, K Figlewski, A R Pedersen, J Jensen, L Baad-Hansen, P Svensson, J F Nielsen
The aim of this study is to investigate effects of transcranial direct current stimulation (tDCS) on neuroplasticity in corticomotor pathways related to tongue muscles evoked by a training task using the tongue drive system (TDS). Using a crossover design, 13 healthy participants completed two sessions of tDCS while performing 30 min of TDS training. Sessions were spaced at least 2 weeks apart and participants randomly received anodal and sham tDCS stimulation in the first session and the other condition in the second session...
September 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28526071/retinoid-acid-induced-microrna-31-5p-suppresses-myogenic-proliferation-and-differentiation-by-targeting-camkii%C3%AE
#16
Bo Liu, Chao Liu, Wei Cong, Nan Li, Nan Zhou, Yi Tang, Chao Wei, Han Bai, Ying Zhang, Jing Xiao
BACKGROUND: We previously reported that Wnt5a/CaMKIIδ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity induced by excess retinoic acid (RA). Our latest study found that the expression of miR-31-5p, which was predicted to target the 3'UTR of CamkIIδ, was raised in the RA-treated embryonic tongue. Thus, we hypothesized that the excess RA regulated Wnt5a/CaMKIIδ pathway through miR-31-5p in embryonic tongue. METHODS: C2C12 myoblast line was employed as an in vitro model to examine the suppression of miR-31-5p on CamkIIδ expression, through which RA impaired the myoblast proliferation and differentiation in embryonic tongue...
May 11, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28521453/nicotine-may-promote-tongue-squamous-cell-carcinoma-progression-by-activating-the-wnt-%C3%AE-catenin-and-wnt-pcp-signaling-pathways
#17
Chengze Wang, Xin Xu, Hairu Jin, Gangli Liu
To investigate the effects and the possible underlying mechanisms of nicotine stimulation on tongue squamous cell carcinoma (TSCC) progression, a TSCC cell line Cal27 and 34 samples of paraffin-embedded TSCC were examined. Immunofluorescence, western blot analysis, and TOP/FOP flash, CCK-8, wound healing and Transwell invasion assays were used to evaluate Cal27 in response to nicotine stimulation. We also investigated expression levels of related proteins of Wnt/β-catenin and Wnt/PCP pathways in paraffin-embedded TSCC samples with or without a history of smoking by immunohistochemistry...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28517962/inhibition-of-the-continuum-of-radiation-induced-normal-tissue-injury-by-a-redox-active-mn-porphyrin
#18
Samuel R Birer, Chen-Ting Lee, Kingshuk Roy Choudhury, Kenneth H Young, Ivan Spasojevic, Ines Batinic-Haberle, James D Crapo, Mark W Dewhirst, Kathleen A Ashcraft
Normal tissue damage after head and neck radiotherapy involves a continuum of pathologic events to the mucosa, tongue and salivary glands. We examined the radioprotective effects of MnBuOE, a redox-active manganese porphyrin, at three stages of normal tissue damage: immediate (leukocyte endothelial cell [L/E] interactions), early (mucositis) and late (xerostomia and fibrosis) after treatment. In this study, mice received 0 or 9 Gy irradiation to the oral cavity and salivary glands ± MnBuOE treatment. Changes in leukocyte-endothelial cell interactions were measured 24 h postirradiation...
July 2017: Radiation Research
https://www.readbyqxmd.com/read/28484380/perceived-intensity-and-discrimination-ability-for-lingual-electrotactile-stimulation-depends-on-location-and-orientation-of-electrodes
#19
Joel Moritz, Philip Turk, John D Williams, Leslie M Stone-Roy
Malfunctioning sensory systems can severely impact quality of life and repair is not always possible. One solution, called sensory substitution, is to use another sensory system to bring lost information to the brain. This approach often involves the use of bioengineered devices that electrically stimulate somatosensory fibers. Interestingly, the tongue is an ideal location for electrotactile stimulation due to its dense innervation, moisture, and protected environment. Success with transmitting visual and vestibular information through the tongue indicates promise for future applications...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28481721/s-oralis-activates-the-efg1-filamentation-pathway-in-c-albicans-to-promote-cross-kingdom-interactions-and-mucosal-biofilms
#20
Hongbin Xu, Takanori Sobue, Martinna Bertolini, Angela Thompson, Margaret Vickerman, Clarissa J Nobile, Anna Dongari-Bagtzoglou
Candida albicans and Streptococcus oralis are ubiquitous oral commensal organisms. Under host-permissive conditions these organisms can form hypervirulent mucosal biofilms. C. albicans biofilm formation is controlled by 6 master transcriptional regulators: Bcr1, Brg1, Efg1, Tec1, Ndt80, and Rob1. The objective of this work was to test whether any of these regulators play a role in cross-kingdom interactions between C. albicans and S. oralis in oral mucosal biofilms, and identify downstream target gene(s) that promote these interactions...
May 8, 2017: Virulence
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