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Tongue stimulation

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https://www.readbyqxmd.com/read/29453996/systematic-review-of-botulinum-toxin-treatment-for-oromandibular-dystonia
#1
Cynthia L Comella
Oromandibular dystonia (OMD) is an isolated focal dystonia that affects the muscles of the jaw, lower face and tongue. It is a rare disorder but is associated with significant impairment in quality of life. Treatment with oral medications has not been successful. Surgical interventions, such as deep brain stimulation, may be of benefit but have not been adequately evaluated. Currently, botulinum toxin (BoNT) injections are regarded as the treatment of choice for OMD. However, the evidence supporting this is not available...
February 14, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29410358/hypoglossal-nerve-stimulation-in-a-pre-clinical-anesthetized-rabbit-model-relevant-to-osa
#2
Girriso F Benderro, Jenniffer Gamble, Matthew A Schiefer, Jonathan Z Baskin, Yeritza Hernandez, Kingman P Strohl
We tested the functional effects of hypoglossal (CNXII) stimulation in the anesthetized rabbit before and after injections of saline into the tongue base to obstruct the airway. Data (n = 6) show little or no effect of CN XII trunk stimulation; however, medial branch stimulation (20-100 Hz; 50-500 μs pulse width, and incremental increases from 10 μA) reduced upper airway resistance. Medial branch stimulation was less effective in reducing resistance than anterior advancement of the hyoid. Endoscopic viewing (n-3) of the retropalate showed this region as the narrowest and dynamically changed by anterior hyoid displacement, with less evident effects than CNXII stimulation...
February 1, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29410235/variation-in-thermally-induced-taste-response-across-thermal-tasters
#3
Martha Skinner, Sally Eldeghaidy, Rebecca Ford, Timo Giesbrecht, Anna Thomas, Susan Francis, Joanne Hort
Thermal tasters (TTs) perceive thermally induced taste (thermal taste) sensations when the tongue is stimulated with temperature in the absence of gustatory stimuli, while thermal non tasters (TnTs) only perceive temperature. This is the first study to explore detailed differences in thermal taste responses across TTs. Using thermal taster status phenotyping, 37 TTs were recruited, and the temporal characteristics of thermal taste responses collected during repeat exposure to temperature stimulation. Phenotyping found sweet most frequently reported during warming stimulation, and bitter and sour when cooling, but a range of other sensations were stated...
February 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29404821/spexin-in-the-half-smooth-tongue-sole-cynoglossus-semilaevis-molecular-cloning-expression-profiles-and-physiological-effects
#4
Shengpeng Wang, Bin Wang, Songlin Chen
Spexin (SPX), a novel neuropeptide discovered by the bioinformatics approach, has been shown to exert pleiotropic functions in mammals. However, little information regarding the physiological role of SPX is available in teleosts. As a first step, we cloned the spexin gene from a flatfish, the half-smooth tongue sole. The open reading frame (ORF) of tongue sole spexin contained 363 nucleotides encoding a 120 amino acid (aa) preprohormone with a calculated molecular mass and isoelectric point of 14.06 kDa and 5...
February 5, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29404215/equine-glucagon-like-peptide-1-receptor-physiology
#5
Murad H Kheder, Simon R Bailey, Kevin J Dudley, Martin N Sillence, Melody A de Laat
Background: Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations of the incretin hormone, glucagon-like peptide-1 (GLP-1) correlate with an increased insulin response to carbohydrate intake in animals with EMS. However, little is known about the equine GLP-1 receptor (eGLP-1R), or whether GLP-1 concentrations can be manipulated. The objectives were to determine (1) the tissue localisation of the eGLP-1R, (2) the GLP-1 secretory capacity of equine intestine in response to glucose and (3) whether GLP-1 stimulated insulin secretion from isolated pancreatic islets can be attenuated...
2018: PeerJ
https://www.readbyqxmd.com/read/29399178/g-csf-producing-oral-carcinoma-with-diffuse-uptake-of-fdg-in-the-bone-marrow-a-case-report
#6
Takeshi Kuroshima, Mayumi Wada, Takehiko Sato, Masashi Takano, Shujiroh Makino
A 78-year-old male patient was referred to the Department of Oral Surgery, Hokuto Hospital (Obihiro, Japan) for painless swelling on the left neck and tongue. Histopathological examination of a biopsy specimen resulted in a diagnosis of squamous cell carcinoma of the tongue. Imaging examinations revealed cervical lymph node metastases on both sides, along with diffuse uptake of 18F-fluorodeoxyglucose (FDG) in the bone marrow of the spine and pelvis. Hematologic tests revealed an increased white blood cell (WBC) count and serum concentrations of granulocyte colony stimulating factor (G-CSF)...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29385406/c-reactive-protein-is-associated-with-the-development-of-tongue-squamous-cell-carcinoma
#7
Jianxin Du, Wei Hu, Chengzhe Yang, Yegang Wang, Xiaoying Wang, Pishan Yang
C-reactive protein (CRP) acts as a biomarker reflecting different degrees of inflammation. Accumulating reports have suggested that there is a close relationship between CRP and various cancers. However, the influence of CRP on the development of tongue squamous cell carcinoma (TSCC) remains unclear. The purpose of this study was to investigate the role of CRP in TSCC. The results of immunohistochemical staining and statistical analyses showed that CRP expression was associated with TSCC tumor size, lymph node metastasis and pathological differentiation...
January 27, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29380619/the-prevalence-of-ankyloglossia-in-302-newborns-with-breastfeeding-problems-and-sucking-difficulties-in-barcelona-a-descriptive-study
#8
E Ferrés-Amat, T Pastor-Vera, P Rodriguez-Alessi, E Ferrés-Amat, J Mareque-Bueno, E Ferrés-Padró
AIM: Oral and maxillofacial development is influenced by the lingual frenulum and also affects breathing, occlusion, sucking, swallowing, speech, among others. Ankyloglossia in the newborn may result in breastfeeding difficulties: maternal nipple pain and/or erosion or mastitis, poor weight gain and excessively long breastfeeds. The main objective of this work is to study the prevalence of ankyloglossia in newborns with breastfeeding difficulties. MATERIALS AND METHODS: This is a transversal descriptive study of 302 patients, between 0 and 6 months, who attended the hospital as a result of breastfeeding difficulties...
December 2017: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29376445/exploring-australian-speech-language-pathologists-use-and-perceptions-ofnon-speech-oral-motor-exercises
#9
Anna F Rumbach, Tanya A Rose, Mynn Cheah
PURPOSE: To explore Australian speech-language pathologists' use of non-speech oral motor exercises, and rationales for using/not using non-speech oral motor exercises in clinical practice. METHODS: A total of 124 speech-language pathologists practising in Australia, working with paediatric and/or adult clients with speech sound difficulties, completed an online survey. RESULTS: The majority of speech-language pathologists reported that they did not use non-speech oral motor exercises when working with paediatric or adult clients with speech sound difficulties...
January 29, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29360662/foxm1-promotes-epithelial-mesenchymal-transition-invasion-and-migration-of-tongue-squamous-cell-carcinoma-cells-through-a-c-met-akt-dependent-positive-feedback-loop
#10
Huiling Yang, Li Wen, Mingling Wen, Tao Liu, Lisheng Zhao, Bo Wu, Yuyu Yun, Wenchao Liu, Hao Wang, Yu Wang, Ning Wen
Forkhead box protein M1 (FoxM1) has been associated with cancer progression and metastasis. However, the function of FoxM1 in tongue squamous cell carcinoma (TSCC) remains largely unknown. The purpose of this study was to determine the role of FoxM1 in regulation of epithelial-mesenchymal transition (EMT) and migration of TSCC cells. We found that FoxM1 induced EMT and increased invasion/migration capacity in SCC9 and SCC25 cells. FoxM1 stimulation increased c-Met, pAKT, and vimentin levels but decreased E-cadherin level...
January 22, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29357492/involvement-of-hypoglossal-and-recurrent-laryngeal-nerves-on-swallowing-pressure
#11
Takanori Tsujimura, Taku Suzuki, Midori Yoshihara, Shogo Sakai, Naomi Koshi, Hirokazu Ashiga, Naru Shiraishi, Kojun Tsuji, Jin Magara, Makoto Inoue
Swallowing pressure generation is important to ensure safe transport of an ingested bolus without aspiration or leaving residue in the pharynx. To clarify the mechanism, we measured swallowing pressure at the oropharynx (OP), upper esophageal sphincter (UES), and cervical esophagus (CE) using a specially designed manometric catheter in anesthetized rats. A swallow-evoked by punctate mechanical stimulation to the larynx-was identified by recording activation of the suprahyoid and thyrohyoid muscles using electromyography (EMG)...
January 4, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29340090/high-glucose-enhances-the-metastatic-potential-of-tongue-squamous-cell-carcinoma-via-the-pkm2-pathway
#12
Wei Wang, Qianting He, Wangxiang Yan, Jingjing Sun, Zujian Chen, Zhonghua Liu, Zhiyuan Lu, Jinsong Hou, Yisen Shao, Xiaofeng Zhou, Anxun Wang
Previous evidence has indicated an increased cancer risk in individuals with diabetes mellitus (DM). The aim of this study was to investigate the relationship between DM (high glucose) and tongue squamous cell carcinoma (TSCC) and how high glucose mediated the metastatic potential of TSCC. The relationship between DM and TSCC was assessed in a retrospective study. The role and its mechanism of high glucose on the proliferation, metastatic potential of TSCC were investigated in vitro and in vivo. The prevalence rate of DM in patients with TSCC was 12...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29330579/-initially-undetected-de-novo-psoriasis-triggered-by-nivolumab-for-metastatic-base-of-the-tongue-carcinoma
#13
S Troyanova-Slavkova, L Eickenscheidt, K Dumann, L Kowalzick
Nivolumab is a monoclonal antibody that binds to the PD-1 receptor on T cells and inhibits the interaction with the PD-L1 and PD-L2 ligands on cancer cells. Thus, nivolumab has immunostimulatory properties. The known side effects of this therapy include fatigue, skin rash, dysfunction of the thyroid gland and colitis, which are explained by the immunoregulatory mechanisms of the drug. Here we report on the case of a 58-year-old man with metastatic base of tongue carcinoma who developed de novo psoriasis triggered by nivolumab...
January 12, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29310635/effect-of-oral-functional-training-on-immunological-abilities-of-older-people-a-case-control-study
#14
Mitsue Sato, Masahiro Sugimoto, Yuko Yamamoto, Juri Saruta, Keiichi Tsukinoki
BACKGROUND: Oral functional ability decreases with age, and systemic immunological ability and quality of life can also deteriorate. Continuous moderate whole-body exercise for older people is known to improve oral functional and their immunological abilities. Here, we evaluated the effect of oral exercise as an alternative training method for highly older people who cannot perform whole-body exercises. METHODS: Unstimulated whole saliva samples had been collected for three times before training as baseline data and one time after 3 and 6 weeks of training each...
January 8, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29285773/functional-architecture-of-the-somatosensory-homunculus-detected-by-electrostimulation
#15
Franck-Emmanuel Roux, Imène Djidjeli, Jean-Baptiste Durand
KEY POINTS: We performed a prospective electrostimulation study, based on 50 operated intact patients, to acquire accurate MNI coordinates of the functional areas of the somatosensory homunculus. In the contralateral BA1, the hand representation displayed not only medial-to-lateral, little-finger-to-thumb, but also rostral-to-caudal discrete somatotopy, with the tip of each finger located more caudally than the proximal phalanx. The analysis of the MNI body coordinates showed rare inter-individual variations in the medial-to-lateral somatotopic organization in these patients with rather different intensity thresholds needed to elicit sensations in different body parts...
December 29, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29280488/tongue-motion-variability-with-changes-of-upper-airway-stimulation-electrode-configuration-and-effects-on-treatment-outcomes
#16
Armin Steffen, Ayse Kilic, Inke R König, Maria V Suurna, Benedikt Hofauer, Clemens Heiser
OBJECTIVES/HYPOTHESIS: Upper airway stimulation (UAS) is an effective treatment for obstructive sleep apnea (OSA). Previous data have demonstrated a correlation between the phenotype of tongue motion and therapy response. Closed loop hypoglossal nerve stimulation implant offers five different electrode configuration settings which may result in different tongue motion. STUDY DESIGN: Two-center, prospective consecutive trial in a university hospital setting. METHODS: Clinical outcomes of 35 patients were analyzed after at least 12 months of device use...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29259570/galvanic-tongue-stimulation-inhibits-five-basic-tastes-induced-by-aqueous-electrolyte-solutions
#17
Kazuma Aoyama, Kenta Sakurai, Satoru Sakurai, Makoto Mizukami, Taro Maeda, Hideyuki Ando
Galvanic tongue stimulation (GTS) modulates taste sensation. However, the effect of GTS is contingent on the electrode polarity in the proximity of the tongue. If an anodal electrode is attached in the proximity of the tongue, an electrical or metallic taste is elicited. On the other hand, if only cathodal electrode is attached in the proximity of the tongue, the salty taste, which is induced by electrolyte materials, is inhibited. The mechanism of this taste inhibition is not adequately understood. In this study, we aim to demonstrate that the inhibition is cause by ions, which elicit taste and which migrate from the taste sensors on the tongue by GTS...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29243157/why-is-a-prone-sleeping-position-dangerous-for-certain-infants
#18
Roger W Byard, Fiona Bright, Robert Vink
The prone (face down) sleeping position is known to be associated with a significantly increased risk of sudden and unexpected death in infancy (sudden infant death syndrome or SIDS), however, the reasons for this are unclear. Suggested mechanisms have involved suffocation from occlusion of the external airways by soft bedding/pillows or from flattening of the nose with backward displacement of the tongue, rebreathing of carbon dioxide, blunting of arousal responses with decreased cardiac responses to auditory stimulation, diaphragmatic splinting or fatigue, lowering of vasomotor tone with tachycardia, nasopharyngeal bacterial overgrowth, overheating, alteration of sleep patterns, compromise of cerebral blood flow and upper airway obstruction from distortion of nasal cartilages...
December 14, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29232055/outcome-of-orthodontic-palatal-plate-therapy-for-orofacial-dysfunction-in-children-with-down-syndrome-a-systematic-review
#19
REVIEW
F Javed, Z Akram, A P Barillas, S V Kellesarian, H B Ahmed, J Khan, K Almas
To evaluate the effects of orthodontic palatal plate therapy (OPPT) in the treatment of orofacial dysfunction in children with Down syndrome (DS). Indexed databases were searched. Clinical trials in DS allocated to test (treatment with palatal plates) versus control group (without palatal plates/special physiotherapy for orofacial stimulation) with follow-up of any time duration and assessing mouth closure, tongue position, active and inactive muscle function as outcomes. Study designs, subject demographics, frequency and duration of palatal plate therapy, method for assessment, follow-up period and outcomes were reported according to the PRISMA guidelines...
December 12, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/29232019/thalamic-deep-brain-stimulation-for-essential-tremor-also-reduces-voice-tremor
#20
Bornali Kundu, Lauren Schrock, Tyler Davis, Paul A House
OBJECTIVE: Voice tremor is a common feature of essential tremor (ET) that is difficult to treat medically and significantly affects quality of life. Deep brain stimulation (DBS) of the ventral intermediate nucleus (Vim) of the thalamus is effective in improving contralateral distal limb tremor and has been shown in limited studies to affect voice tremor. Our objective was to retrospectively evaluate whether Vim-DBS used to treat patients with essential motor tremor also effectively treated underlying concurrent voice tremor and assess whether particular lead locations were favorable for treating vocal tremor...
December 12, 2017: Neuromodulation: Journal of the International Neuromodulation Society
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