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https://www.readbyqxmd.com/read/27797313/closing-the-mortality-gap-mental-illness-and-medical-care
#1
Lisa Rosenbaum
No abstract text is available yet for this article.
October 20, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27783917/unlearning-our-helplessness-coexisting-serious-mental-and-medical-illness
#2
Lisa Rosenbaum
No abstract text is available yet for this article.
October 27, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27732817/liberty-versus-need-our-struggle-to-care-for-people-with-serious-mental-illness
#3
Lisa Rosenbaum
In 1985, when internist Jim O’Connell, cofounder of the Boston Health Care for the Homeless Program, began doing outreach to homeless people, one of the toughest questions he faced was whether to commit someone to the hospital for involuntary psychiatric treatment. States vary in their criteria for..
October 13, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27512653/does-the-urinary-microbiome-play-a-role-in-urgency-urinary-incontinence-and-its-severity
#4
Lisa Karstens, Mark Asquith, Sean Davin, Patrick Stauffer, Damien Fair, W Thomas Gregory, James T Rosenbaum, Shannon K McWeeney, Rahel Nardos
OBJECTIVES: Traditionally, the urinary tract has been thought to be sterile in the absence of a clinically identifiable infection. However, recent evidence suggests that the urinary tract harbors a variety of bacterial species, known collectively as the urinary microbiome, even when clinical cultures are negative. Whether these bacteria promote urinary health or contribute to urinary tract disease remains unknown. Emerging evidence indicates that a shift in the urinary microbiome may play an important role in urgency urinary incontinence (UUI)...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27415793/gut-microbial-alterations-associated-with-protection-from-autoimmune-uveitis
#5
Yukiko K Nakamura, Christina Metea, Lisa Karstens, Mark Asquith, Henry Gruner, Cathleen Moscibrocki, Iris Lee, Colin J Brislawn, Janet K Jansson, James T Rosenbaum, Phoebe Lin
PURPOSE: To investigate the contribution of the gut microbiota to the pathogenesis of uveitis. METHODS: Experimental autoimmune uveitis (EAU) in B10.RIII mice was induced using interphotoreceptor binding protein peptide. Mice were treated with oral or intraperitoneal (IP) antibiotics. Effector (Teff) and regulatory (Treg) T lymphocytes were identified using flow cytometry; 16S rRNA gene sequencing and qPCR were performed on gastrointestinal (GI) contents. RESULTS: Broad-spectrum (four antibiotics given simultaneously) oral, but not IP, antibiotics reduced mean uveitis clinical scores significantly compared with water-treated animals (0...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27149908/bridging-the-academia-industry-chasm-proposed-solutions
#6
Paul Beninger, Marcia Boumil, Deeb Salem, Kenneth Getz, Henry Klapholz, Gregory D Curfman, Rohan Jotwani, Harris Berman
No abstract text is available yet for this article.
December 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27144356/crystal-structure-of-the-human-sterol-transporter-abcg5-abcg8
#7
Jyh-Yeuan Lee, Lisa N Kinch, Dominika M Borek, Jin Wang, Junmei Wang, Ina L Urbatsch, Xiao-Song Xie, Nikolai V Grishin, Jonathan C Cohen, Zbyszek Otwinowski, Helen H Hobbs, Daniel M Rosenbaum
ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines. Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol accumulation and premature atherosclerosis. Here we use crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 Å resolution, generating the first atomic model of an ABC sterol transporter...
May 4, 2016: Nature
https://www.readbyqxmd.com/read/27068746/direct-demonstration-that-loop1-of-scap-binds-to-loop7-a-crucial-event-in-cholesterol-homeostasis
#8
Yinxin Zhang, Kwang Min Lee, Lisa N Kinch, Lindsay Clark, Nick V Grishin, Daniel M Rosenbaum, Michael S Brown, Joseph L Goldstein, Arun Radhakrishnan
Cholesterol homeostasis is mediated by Scap, a polytopic endoplasmic reticulum (ER) protein that transports sterol regulatory element-binding proteins from the ER to Golgi, where they are processed to forms that activate cholesterol synthesis. Scap has eight transmembrane helices and two large luminal loops, designated Loop1 and Loop7. We earlier provided indirect evidence that Loop1 binds to Loop7, allowing Scap to bind COPII proteins for transport in coated vesicles. When ER cholesterol rises, it binds to Loop1...
June 10, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26962735/n-of-1-policymaking-tragedy-trade-offs-and-the-demise-of-morcellation
#9
Lisa Rosenbaum
No abstract text is available yet for this article.
March 10, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26836311/leaping-without-looking-duty-hours-autonomy-and-the-risks-of-research-and-practice
#10
Lisa Rosenbaum
In 2014, Facebook users were furious to discover that they’d unwittingly been experimented on. Researchers had randomly assigned users to news feeds with reduced "positive" content or reduced "negative" content and found that happy posts beget happy posts and that grim ones beget grim ones...
February 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26759931/falling-together-empathetic-care-for-the-dying
#11
Lisa Rosenbaum
No abstract text is available yet for this article.
February 11, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26488690/transitional-chaos-or-enduring-harm-the-ehr-and-the-disruption-of-medicine
#12
Lisa Rosenbaum
A decade ago, a primary care physician I admired seemed to come undone. His efficiency had derived not from rushing between patients but from knowing them so well that his charting was effortless and fast. But suddenly he became distracted, losing his grip on the details of his patients' lives. He..
October 22, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26332360/scoring-no-goal-further-adventures-in-transparency
#13
Lisa Rosenbaum
One Monday morning, rounding on a patient who needed relatively urgent coronary-artery bypass surgery, a newly appointed cardiologist in New York asked the team to call a surgical consult (some details have been changed to protect those involved). "We can't call today," the cardiology fellow..
October 8, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26267618/the-paternalism-preference-choosing-unshared-decision-making
#14
Lisa Rosenbaum
The day after 19-year-old Jerry Canterbury underwent surgical laminectomy, he fell out of bed and became paralyzed from the waist down. His neurosurgeon, William Spence, reoperated to relieve pressure on the spinal cord, restoring most motor function. But Canterbury had enduring bowel and bladder..
August 13, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26206558/erbb3-erbb2-complexes-as-a-therapeutic-target-in-a-subset-of-wild-type-braf-nras-cutaneous-melanomas
#15
Claudia Capparelli, Sheera Rosenbaum, Lisa D Berman-Booty, Amel Salhi, Nadège Gaborit, Tingting Zhan, Inna Chervoneva, Jason Roszik, Scott E Woodman, Michael A Davies, Yulius Y Setiady, Iman Osman, Yosef Yarden, Andrew E Aplin
The treatment options remain limited for patients with melanoma who are wild-type for both BRAF and NRAS (WT/WT). We demonstrate that a subgroup of WT/WT melanomas display high basal phosphorylation of ErbB3 that is associated with autocrine production of the ErbB3 ligand neuregulin-1 (NRG1). In WT/WT melanoma cells displaying high levels of phospho-ErbB3, knockdown of NRG1 reduced cell viability and was associated with decreased phosphorylation of ErbB3, its coreceptor ErbB2, and its downstream target, AKT...
September 1, 2015: Cancer Research
https://www.readbyqxmd.com/read/25992752/beyond-moral-outrage-weighing-the-trade-offs-of-coi-regulation
#16
Lisa Rosenbaum
New England Journal of Medicine, Volume 372, Issue 21, Page 2064-2068, May 2015.
May 21, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25970055/understanding-bias-the-case-for-careful-study
#17
Lisa Rosenbaum
No abstract text is available yet for this article.
May 14, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25946288/conflicts-of-interest-part-1-reconnecting-the-dots-reinterpreting-industry-physician-relations
#18
Lisa Rosenbaum
New England Journal of Medicine, Volume 372, Issue 19, Page 1860-1864, May 2015.
May 7, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25651078/being-like-mike-fear-trust-and-the-tragic-death-of-michael-davidson
#19
Lisa Rosenbaum
Around 11:00 a.m. on January 20, 2015, Stephen Pasceri arrived at the cardiovascular center at Boston's Brigham and Women's Hospital, where he had an appointment to speak to Michael Davidson, a 44-year-old surgeon who had performed valve surgery on Pasceri's mother a few months earlier. Davidson..
February 26, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25581599/pheochromocytoma-and-paraganglioma-in-cyanotic-congenital-heart-disease
#20
Alexander R Opotowsky, Lilamarie E Moko, Jonathan Ginns, Marlon Rosenbaum, Matthias Greutmann, Jamil Aboulhosn, Abbie Hageman, Yuli Kim, Lisa X Deng, Jasmine Grewal, Ali N Zaidi, Ghadeera Almansoori, Erwin Oechslin, Michael Earing, Michael J Landzberg, Michael N Singh, Fred Wu, Anand Vaidya
CONTEXT: Aberrant cellular oxygen sensing is a leading theory for development of pheochromocytoma (PHEO) and paraganglioma (PGL). OBJECTIVE: The objective of the study was to test the hypothesis that chronic hypoxia in patients with cyanotic congenital heart disease (CCHD) increases the risk for PHEO-PGL. DESIGN/SETTING/PARTICIPANTS: We investigated the association between CCHD and PHEO-PGL with two complementary studies: study 1) an international consortium was established to identify congenital heart disease (CHD) patients with a PHEO-PGL diagnosis confirmed by pathology or biochemistry and imaging; study 2) the 2000-2009 Nationwide Inpatient Survey, a nationally representative discharge database, was used to determine population-based cross-sectional PHEO-PGL frequency in hospitalized CCHD patients compared with noncyanotic CHD and those without CHD using multivariable logistic regression adjusted for age, sex, and genetic PHEO-PGL syndromes...
April 2015: Journal of Clinical Endocrinology and Metabolism
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