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https://www.readbyqxmd.com/read/29091553/understanding-the-planned-parenthood-divide-albert-lasker-and-women-s-health
#1
Lisa Rosenbaum
Albert Lasker, considered the "father of modern advertising," transformed product marketing from an endeavor based on the simple presentation of facts to one finely tuned to consumer psychology, particularly as it pertained to women. At a time when discussion of menstruation was taboo, for example,..
November 1, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28924192/short-chain-fatty-acids-ameliorate-immune-mediated-uveitis-partially-by-altering-migration-of-lymphocytes-from-the-intestine
#2
Yukiko K Nakamura, Cathleen Janowitz, Christina Metea, Mark Asquith, Lisa Karstens, James T Rosenbaum, Phoebe Lin
Short chain fatty acids (SCFA) are metabolites of intestinal bacteria resulting from fermentation of dietary fiber. SCFA are protective in various animal models of inflammatory disease. We investigated the effects of exogenous administration of SFCAs, particularly propionate, on uveitis using an inducible model of experimental autoimmune uveitis (EAU). Oral SCFA administration attenuated uveitis severity in a mouse strain-dependent manner through regulatory T cell induction among lymphocytes in the intestinal lamina propria (LPL) and cervical lymph nodes (CLN)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902570/tragedy-perseverance-and-chance-the-story-of-car-t-therapy
#3
Lisa Rosenbaum
In 2010, 5-year-old Emily Whitehead was diagnosed with acute lymphoblastic leukemia (ALL). Though her parents were told that if you had to have a kid with cancer, ALL was the best one to have, Emily’s course was hardly typical. After two rounds of chemotherapy, necrotizing fasciitis developed in..
October 5, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28514226/the-march-of-science-the-true-story
#4
Lisa Rosenbaum
"The human understanding when it has once adopted an opinion...draws all things else to support and agree with it." Francis Bacon, the "Father of Empiricism," came to this conclusion in the 17th century, and some 350 years later, three Stanford psychologists confirmed its validity. They recruited..
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28485850/child-and-parent-reported-quality-of-life-trajectories-in-children-with-epilepsy-a-prospective-cohort-study
#5
COMPARATIVE STUDY
Mark A Ferro, Lisa Avery, Nora Fayed, David L Streiner, Charles E Cunningham, Michael H Boyle, Lucyna Lach, Gina Glidden, Peter L Rosenbaum, Gabriel M Ronen
OBJECTIVE: To describe the developmental trajectories of quality of life (QoL) in a large cohort of children with epilepsy, and to assess the relative contribution of clinical, psychosocial, and sociodemographic variables on QoL trajectories. METHODS: Five assessments during a 28-month prospective cohort study were used to model trajectories of QoL. Participants were recruited with their parents from six Canadian tertiary centers. A convenience sample of 506 children aged 8-14 years with epilepsy and without intellectual disability or autism spectrum disorder were enrolled...
July 2017: Epilepsia
https://www.readbyqxmd.com/read/28445080/bridging-the-data-sharing-divide-seeing-the-devil-in-the-details-not-the-other-camp
#6
Lisa Rosenbaum
New England Journal of Medicine, Volume 376, Issue 23, Page 2201-2203, June 2017.
June 8, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28248549/resisting-the-suppression-of-science
#7
Lisa Rosenbaum
All doctors encounter patients who express preferences for non–evidence-based therapies — organic food for coronary disease or detox cleanses for cancer, for example. Personally, I’ve never come up with an effective response. I offer facts, and then, sensing that I’m getting nowhere, I offer more..
April 27, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/27941249/deficiency-in-prohormone-convertase-pc1-impairs-prohormone-processing-in-prader-willi-syndrome
#8
Lisa C Burnett, Charles A LeDuc, Carlos R Sulsona, Daniel Paull, Richard Rausch, Sanaa Eddiry, Jayne F Martin Carli, Michael V Morabito, Alicja A Skowronski, Gabriela Hubner, Matthew Zimmer, Liheng Wang, Robert Day, Brynn Levy, Ilene Fennoy, Beatrice Dubern, Christine Poitou, Karine Clement, Merlin G Butler, Michael Rosenbaum, Jean Pierre Salles, Maithe Tauber, Daniel J Driscoll, Dieter Egli, Rudolph L Leibel
Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH). Rare microdeletions in PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes, including the noncoding RNA gene SNORD116. Here, we found that protein and transcript levels of nescient helix loop helix 2 (NHLH2) and the prohormone convertase PC1 (encoded by PCSK1) were reduced in PWS patient induced pluripotent stem cell-derived (iPSC-derived) neurons...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27797313/closing-the-mortality-gap-mental-illness-and-medical-care
#9
Lisa Rosenbaum
No abstract text is available yet for this article.
October 20, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27783917/unlearning-our-helplessness-coexisting-serious-mental-and-medical-illness
#10
Lisa Rosenbaum
No abstract text is available yet for this article.
October 27, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27732817/liberty-versus-need-our-struggle-to-care-for-people-with-serious-mental-illness
#11
Lisa Rosenbaum
In 1985, when internist Jim O’Connell, cofounder of the Boston Health Care for the Homeless Program, began doing outreach to homeless people, one of the toughest questions he faced was whether to commit someone to the hospital for involuntary psychiatric treatment. States vary in their criteria for..
October 13, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27512653/does-the-urinary-microbiome-play-a-role-in-urgency-urinary-incontinence-and-its-severity
#12
Lisa Karstens, Mark Asquith, Sean Davin, Patrick Stauffer, Damien Fair, W Thomas Gregory, James T Rosenbaum, Shannon K McWeeney, Rahel Nardos
OBJECTIVES: Traditionally, the urinary tract has been thought to be sterile in the absence of a clinically identifiable infection. However, recent evidence suggests that the urinary tract harbors a variety of bacterial species, known collectively as the urinary microbiome, even when clinical cultures are negative. Whether these bacteria promote urinary health or contribute to urinary tract disease remains unknown. Emerging evidence indicates that a shift in the urinary microbiome may play an important role in urgency urinary incontinence (UUI)...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27415793/gut-microbial-alterations-associated-with-protection-from-autoimmune-uveitis
#13
Yukiko K Nakamura, Christina Metea, Lisa Karstens, Mark Asquith, Henry Gruner, Cathleen Moscibrocki, Iris Lee, Colin J Brislawn, Janet K Jansson, James T Rosenbaum, Phoebe Lin
PURPOSE: To investigate the contribution of the gut microbiota to the pathogenesis of uveitis. METHODS: Experimental autoimmune uveitis (EAU) in B10.RIII mice was induced using interphotoreceptor binding protein peptide. Mice were treated with oral or intraperitoneal (IP) antibiotics. Effector (Teff) and regulatory (Treg) T lymphocytes were identified using flow cytometry; 16S rRNA gene sequencing and qPCR were performed on gastrointestinal (GI) contents. RESULTS: Broad-spectrum (four antibiotics given simultaneously) oral, but not IP, antibiotics reduced mean uveitis clinical scores significantly compared with water-treated animals (0...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27149908/bridging-the-academia-industry-chasm-proposed-solutions
#14
Paul Beninger, Marcia Boumil, Deeb Salem, Kenneth Getz, Henry Klapholz, Gregory D Curfman, Rohan Jotwani, Harris Berman
No abstract text is available yet for this article.
December 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27144356/crystal-structure-of-the-human-sterol-transporter-abcg5-abcg8
#15
Jyh-Yeuan Lee, Lisa N Kinch, Dominika M Borek, Jin Wang, Junmei Wang, Ina L Urbatsch, Xiao-Song Xie, Nikolai V Grishin, Jonathan C Cohen, Zbyszek Otwinowski, Helen H Hobbs, Daniel M Rosenbaum
ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines. Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol accumulation and premature atherosclerosis. Here we use crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 Å resolution, generating the first atomic model of an ABC sterol transporter...
May 26, 2016: Nature
https://www.readbyqxmd.com/read/27068746/direct-demonstration-that-loop1-of-scap-binds-to-loop7-a-crucial-event-in-cholesterol-homeostasis
#16
Yinxin Zhang, Kwang Min Lee, Lisa N Kinch, Lindsay Clark, Nick V Grishin, Daniel M Rosenbaum, Michael S Brown, Joseph L Goldstein, Arun Radhakrishnan
Cholesterol homeostasis is mediated by Scap, a polytopic endoplasmic reticulum (ER) protein that transports sterol regulatory element-binding proteins from the ER to Golgi, where they are processed to forms that activate cholesterol synthesis. Scap has eight transmembrane helices and two large luminal loops, designated Loop1 and Loop7. We earlier provided indirect evidence that Loop1 binds to Loop7, allowing Scap to bind COPII proteins for transport in coated vesicles. When ER cholesterol rises, it binds to Loop1...
June 10, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26962735/n-of-1-policymaking-tragedy-trade-offs-and-the-demise-of-morcellation
#17
Lisa Rosenbaum
No abstract text is available yet for this article.
March 10, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26836311/leaping-without-looking-duty-hours-autonomy-and-the-risks-of-research-and-practice
#18
Lisa Rosenbaum
In 2014, Facebook users were furious to discover that they’d unwittingly been experimented on. Researchers had randomly assigned users to news feeds with reduced "positive" content or reduced "negative" content and found that happy posts beget happy posts and that grim ones beget grim ones...
February 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26759931/falling-together-empathetic-care-for-the-dying
#19
Lisa Rosenbaum
No abstract text is available yet for this article.
February 11, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26488690/transitional-chaos-or-enduring-harm-the-ehr-and-the-disruption-of-medicine
#20
Lisa Rosenbaum
A decade ago, a primary care physician I admired seemed to come undone. His efficiency had derived not from rushing between patients but from knowing them so well that his charting was effortless and fast. But suddenly he became distracted, losing his grip on the details of his patients' lives. He..
October 22, 2015: New England Journal of Medicine
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